{ "timeline_id": "HITL-EIMM-001", "title": "Human Infra 永生史严肃历史年表", "version": "2.402.3", "description": "从《人类永生研究：大历史重要事件一览》与公共永生史转成的结构化年表；2571 条事件、2581 个来源卡片、31 个时期定义。", "updated_at": "2026-08-08T06:29:40Z", "events": [ { "event_id": "HIT-MTH-001", "title": "古埃及金字塔文出现", "date_start": "-2353~", "date_end": "-2323~", "date_type": "range", "period_id": "period-ancient-egypt-old-kingdom", "civilization": "Ancient Egypt", "region": "Nile Valley", "path_family": "philosophical", "event_type": "religious", "claim": "古埃及现存较早的《金字塔文》把死后复活和升天纳入王权、尸体保存与宇宙秩序制度。", "summary": "金字塔文表明早期永生观首先是围绕法老死亡、仪式和来世秩序建立的制度性叙事。", "sources": [ "SRC-001" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "文本形成和固定时间存在学术争议，暂以约公元前 2353-前 2323 年作为参考窗口。", "cross_links": [ "HIT-LIT-001" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-LIT-001", "title": "《吉尔伽美什史诗》文本形成", "date_start": "-2100~", "date_end": "-1200~", "date_type": "range", "period_id": "period-mesopotamia-second-millennium-bce", "civilization": "Mesopotamia", "region": "Tigris-Euphrates", "path_family": "philosophical", "event_type": "literature", "claim": "恩奇都之死促使吉尔伽美什寻找不死之法，但最终失去返老还童之物，被迫接受人的有限性。", "summary": "史诗把“永生追求为何失败”变成人类最早的文学和思想主题之一。", "sources": [ "SRC-002" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "史诗经历长期口传、增补和编纂，不能用单一年份代表形成。", "cross_links": [ "HIT-MTH-001" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-MTH-002", "title": "琐罗亚斯德教复活与末日更新观念形成", "date_start": "-1000~", "date_end": "-500~", "date_type": "range", "period_id": "period-zoroastrian-formation", "civilization": "Iranian civilizations", "region": "Iranian Plateau", "path_family": "philosophical", "event_type": "religious", "claim": "琐罗亚斯德教传统把永生从少数英雄或君王的特权，转化为与道德选择、历史终点和普遍救赎相关的体系。", "summary": "该观念对后来的犹太教、基督教和伊斯兰教末世观产生重要影响。", "sources": [ "SRC-003" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "具体形成时间仍有争议，本文使用宽范围表达。", "cross_links": [ "HIT-MTH-003", "HIT-MTH-004" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-THT-001", "title": "印度《奥义书》传统形成", "date_start": "-800~", "date_end": "-300~", "date_type": "range", "period_id": "period-vedic-upanishadic", "civilization": "Ancient India", "region": "Indo-Gangetic Plain", "path_family": "philosophical", "event_type": "thought", "claim": "《奥义书》中的“不死”可指长寿、死后升天、摆脱轮回、认识自我与梵的关系，甚至在后代和社会记忆中延续。", "summary": "永生概念由此从身体问题转向存在论和自我认识问题。", "sources": [ "SRC-004" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "奥义书文本经历长期编纂，日期只能表达传统形成期。", "cross_links": [ "HIT-THT-002" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-THT-002", "title": "早期佛教无常、无我与涅槃理论形成", "date_start": "-500~", "date_type": "approx", "period_id": "period-early-buddhist", "civilization": "Ancient India", "region": "Gangetic Plain", "path_family": "philosophical", "event_type": "thought", "claim": "佛教并不以保存一个永久不变的灵魂为目标，而是解释身心过程如何因缘相续，以及如何终止导致生死轮回的条件。", "summary": "这构成了对“个人实体永生”观念的重要反思。", "sources": [ "SRC-005" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "早期佛教口传与文本化过程复杂，约公元前 5 世纪为传统时间框架。", "cross_links": [ "HIT-THT-001" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-THT-003", "title": "柏拉图《斐多篇》讨论灵魂不朽", "date_start": "-360~", "date_type": "approx", "period_id": "period-classical-greece", "civilization": "Ancient Greece", "region": "Athens", "path_family": "philosophical", "event_type": "thought", "claim": "《斐多篇》把死亡解释为灵魂与身体的分离，并尝试用哲学论证而非单纯神话说明死后存续。", "summary": "该文本成为西方灵魂不朽思想的核心文献。", "sources": [ "SRC-006" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "作品具体写作年份通常取约公元前 360 年前后。", "cross_links": [], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-PRA-001", "title": "秦始皇遣徐福入海求不死之药", "date_start": "-219", "date_type": "approx", "period_id": "period-qin-dynasty", "civilization": "China", "region": "Eastern China / East China Sea", "path_family": "cross_path", "event_type": "practice", "claim": "秦始皇接受徐福等方士建议，派人入海寻找蓬莱等仙山和“不死之药”，把方仙信仰与帝王权力和药物实践结合。", "summary": "这是中国国家权力参与长生追求的代表性节点。", "sources": [ "SRC-007" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "徐福后来到达何处的说法多属后世传说，本事件只确认《史记》记载的入海求药行动。", "cross_links": [], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-PRA-002", "title": "阿育吠陀 rasayana 长生法逐步系统化", "date_start": "1~", "date_end": "500~", "date_type": "range", "period_id": "period-ayurveda-classical", "civilization": "India", "region": "South Asia", "path_family": "maintenance", "event_type": "practice", "claim": "印度医学经典逐步整理出较系统的“长生法”或“滋补复壮术”，重点通常是增强体力、记忆、抵抗力和寿命，而不是绝对不死。", "summary": "永生追求开始与饮食、药物、生活方式和临床经验结合。", "sources": [ "SRC-008" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "文本整理跨度较大，约公元前后至公元数世纪是宽范围表述。", "cross_links": [ "HIT-PRA-004" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-MTH-003", "title": "早期基督教围绕耶稣复活建立救赎信仰", "date_start": "1", "date_end": "100~", "date_type": "era", "period_id": "period-early-christianity", "civilization": "Roman Empire", "region": "Eastern Mediterranean", "path_family": "philosophical", "event_type": "religious", "claim": "永生由单纯的灵魂存续进一步发展为身体复活、末日审判和人与上帝关系的恢复。", "summary": "基督教永生观对欧洲和近东社会的死亡观、墓葬制度与伦理秩序产生长期影响。", "sources": [ "SRC-009" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "公元 1 世纪是观念形成的宽泛时代框架，具体文本时间需要分别复核。", "cross_links": [ "HIT-MTH-004" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-PRA-003", "title": "佐西莫斯炼金术文献形成", "date_start": "250~", "date_end": "325~", "date_type": "range", "period_id": "period-late-antique-alchemy", "civilization": "Greco-Roman Egypt", "region": "Nile Delta", "path_family": "cross_path", "event_type": "practice", "claim": "佐西莫斯将金属转化、仪器操作、宗教净化和人的精神转化联系起来，是希腊化炼金术走向理论体系的重要节点。", "summary": "炼金术从零散技艺变成带有理论结构的传统。", "sources": [ "SRC-010" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "佐西莫斯活动年代有争议，约公元 3 世纪末至 4 世纪初。", "cross_links": [ "HIT-PRA-005" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-THT-004", "title": "葛洪完成《抱朴子内篇》主体内容", "date_start": "317~", "date_type": "approx", "period_id": "period-eastern-jin", "civilization": "China", "region": "Jiangnan", "path_family": "cross_path", "event_type": "thought", "claim": "葛洪系统讨论神仙是否可能、金丹原料、服食、导引和修炼方法，把中国早期方术整理为较完整的长生成仙理论。", "summary": "《抱朴子内篇》同时记录了大量后来证明有毒的矿物药物。", "sources": [ "SRC-011" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "约公元 317 年前后是传统说法，文本修订和流传需要进一步复核。", "cross_links": [ "HIT-PRA-004" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-MTH-004", "title": "伊斯兰教复活、审判与后世生命观念发展", "date_start": "601", "date_type": "long_process", "period_id": "period-early-islamic", "civilization": "Islamic civilization", "region": "Middle East", "path_family": "philosophical", "event_type": "religious", "claim": "伊斯兰文明吸收希腊、波斯和印度医学与炼金知识，使宗教性的永恒生命与现实中的养生、制药和物质研究并行发展。", "summary": "该时期把复活、审判和后世生命观念与世俗知识传统同时推进。", "sources": [ "SRC-009" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "7 世纪以后是长时段过程，不应理解为单一事件。", "cross_links": [ "HIT-MTH-003", "HIT-THT-005" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-THT-005", "title": "贾比尔文献群形成", "date_start": "750~", "date_end": "950~", "date_type": "range", "period_id": "period-abbasid", "civilization": "Islamic civilization", "region": "Middle East", "path_family": "cross_path", "event_type": "thought", "claim": "贾比尔文献群发展出蒸馏、结晶、矿物处理和“灵药”理论，对伊斯兰医学和炼金术影响巨大。", "summary": "这些文本是否均出自一位名叫贾比尔的作者，学界存在明显争议。", "sources": [ "SRC-012" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "作者归属和文本年代争议明显，不能简单视为单一人物体系。", "cross_links": [ "HIT-PRA-005" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-PRA-004", "title": "中国内丹传统在唐宋时期逐渐成熟", "date_start": "850~", "date_end": "1279~", "date_type": "range", "period_id": "period-tang-song-china", "civilization": "China", "region": "China", "path_family": "maintenance", "event_type": "practice", "claim": "修炼重点由服食外部矿物丹药转向以身体为炉鼎，通过精、气、神转化实现“内在成丹”。", "summary": "这反映了外丹风险、宗教修炼与身体观念发生的结构性转折。", "sources": [ "SRC-013" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "内丹并非在某一年突然出现，唐宋只是逐渐系统化的阶段。", "cross_links": [ "HIT-THT-004" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-PRA-005", "title": "拉丁欧洲吸收阿拉伯炼金术与伪盖伯文献", "date_start": "1150~", "date_end": "1400~", "date_type": "range", "period_id": "period-latin-medieval", "civilization": "Latin Europe", "region": "Europe", "path_family": "cross_path", "event_type": "practice", "claim": "阿拉伯炼金术、医学和药物知识大规模传入拉丁欧洲，“长生灵药”仍与宗教象征和金属转化混杂。", "summary": "炼金术开始成为欧洲自然哲学和医学的组成部分，为实验技术和药剂学提供部分方法基础。", "sources": [ "SRC-012" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "伪盖伯文献的作者和年代有争议，约 12-14 世纪是宽范围表述。", "cross_links": [ "HIT-THT-005" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-LIT-002", "title": "百回本《西游记》基本定型", "date_start": "1580~", "date_type": "approx", "period_id": "period-ming-qing-literature", "civilization": "China", "region": "China", "path_family": "philosophical", "event_type": "literature", "claim": "作品通过蟠桃、金丹、人参果和各种长生术，把道教神仙体系、佛教轮回观念和民间故事综合为大众文学世界。", "summary": "永生观从宫廷和宗教专业知识广泛进入通俗文化。", "sources": [ "SRC-014" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "16 世纪后期是传统定型窗口，具体作者归属仍有讨论。", "cross_links": [], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-THT-006", "title": "培根《生命与死亡史》出版", "date_start": "1623", "date_type": "approx", "period_id": "period-early-modern-europe", "civilization": "England", "region": "England", "path_family": "maintenance", "event_type": "thought", "claim": "培根主张通过系统观察研究衰老、营养、呼吸和身体修复，把“延长生命”纳入自然史和实验知识计划。", "summary": "该文本标志着长寿问题开始摆脱纯粹炼金术框架。", "sources": [ "SRC-015" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "文本对后世实验医学的实际影响程度仍属历史解释问题。", "cross_links": [ "HIT-THT-007" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-LIT-003", "title": "斯威夫特《格列佛游记》出版", "date_start": "1726", "date_type": "approx", "period_id": "period-early-modern-europe", "civilization": "Britain", "region": "Britain", "path_family": "philosophical", "event_type": "literature", "claim": "“斯特鲁布鲁格人”能够不死却不能停止衰老，把健康、尊严和社会身份引入永生讨论。", "summary": "作品反驳了“寿命无限必然带来幸福”的直觉。", "sources": [ "SRC-016" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "文学隐喻不等于经验事实，本事件定位为思想文献。", "cross_links": [ "HIT-LIT-004" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-007", "title": "孔多塞《人类精神进步史表纲要》出版", "date_start": "1795", "date_type": "approx", "period_id": "period-enlightenment", "civilization": "France", "region": "France", "path_family": "maintenance", "event_type": "thought", "claim": "孔多塞设想医学和知识进步可能使人类寿命不断延长，首次把寿命的“无确定上限”明确放入启蒙时代历史进步理论。", "summary": "该文本未断言人会真正不死，但为寿命延长提供了启蒙叙事。", "sources": [ "SRC-017" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "死后出版时间 1795 年是公认版本信息，文本写作稍早。", "cross_links": [ "HIT-THT-006" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-PRA-006", "title": "胡费兰《长寿学》出版", "date_start": "1796", "date_type": "approx", "period_id": "period-enlightenment", "civilization": "Germany", "region": "Germany", "path_family": "maintenance", "event_type": "practice", "claim": "胡费兰试图把作息、饮食、环境、心理和疾病预防组织为系统的延寿知识。", "summary": "长寿从秘方逐步转向公共卫生和生活方式管理。", "sources": [ "SRC-018" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "书名以多种语言传播，具体版本差异需要单独核对。", "cross_links": [], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-DEM-001", "title": "冈珀茨发表成人死亡率指数增长模型", "date_start": "1825", "date_type": "approx", "period_id": "period-19th-century", "civilization": "Britain", "region": "Britain", "path_family": "maintenance", "event_type": "demographic", "claim": "成年后的死亡风险大体随年龄呈指数增长，使衰老获得可计算的群体尺度。", "summary": "该模型成为精算、人口学、生物老年学和寿命上限争论的重要数学基础。", "sources": [ "SRC-019" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "指数模型是群体近似，不适用于解释个体死亡机制。", "cross_links": [ "HIT-DEM-002" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-LIT-004", "title": "玛丽·雪莱发表《凡人不死者》", "date_start": "1833", "date_type": "approx", "period_id": "period-19th-century", "civilization": "Britain", "region": "Britain", "path_family": "philosophical", "event_type": "literature", "claim": "主人公误饮长生药后经历爱人衰老、孤独和身份断裂，把永生从愿望改写为伦理和心理困境。", "summary": "作品影响了后来“永生是一种诅咒”的文学传统。", "sources": [ "SRC-020" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "短篇版本与首刊信息需要按版本学核对。", "cross_links": [ "HIT-LIT-003" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-008", "title": "魏斯曼从进化论讨论衰老与死亡", "date_start": "1881~", "date_type": "approx", "period_id": "period-19th-century", "civilization": "Germany", "region": "Germany", "path_family": "maintenance", "event_type": "thought", "claim": "魏斯曼提出个体死亡可能服务于种群更新，推动“衰老是否主动演化出的程序”这一关键问题。", "summary": "其简单的程序性死亡解释后来受到广泛修正或否定。", "sources": [ "SRC-021" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "具体著作年份约 1881 年前后，理论解释应保留后续修正。", "cross_links": [ "HIT-THT-011", "HIT-THT-012" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-FAI-001", "title": "布朗—塞卡尔动物睾丸提取物自我实验", "date_start": "1889", "date_type": "approx", "period_id": "period-19th-century", "civilization": "France", "region": "France", "path_family": "reconstruction", "event_type": "failure", "claim": "布朗—塞卡尔向自己注射动物睾丸提取物并宣称体力和精神状态改善，引发近代第一轮大规模“返老还童”热潮。", "summary": "该事件成为自我实验、安慰剂效应、媒体宣传和商业夸大的早期典型。", "sources": [ "SRC-022" ], "evidence_grade": "L", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "当时的报告缺少现代对照和盲法，宣称效果不能视为可靠疗效。", "cross_links": [ "HIT-SCI-001" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-LIT-005", "title": "王尔德《道林·格雷的画像》首次发表", "date_start": "1890", "date_type": "approx", "period_id": "period-19th-century", "civilization": "Britain", "region": "Britain", "path_family": "philosophical", "event_type": "literature", "claim": "作品让人物保持青春而画像承担衰老和道德腐败，把永葆青春与人格责任分离。", "summary": "它强化了现代文化对“年轻身体不等于完整生命”的反思。", "sources": [ "SRC-023" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "1890 年首次发表与 1891 年单行本差异需要按版本学说明。", "cross_links": [ "HIT-LIT-004" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-009", "title": "梅契尼科夫推广“老年学”概念", "date_start": "1903~", "date_type": "approx", "period_id": "period-20th-century", "civilization": "France", "region": "France", "path_family": "maintenance", "event_type": "thought", "claim": "梅契尼科夫将衰老作为可以进行生物学和医学研究的对象，并研究肠道微生物、饮食与长寿。", "summary": "其具体理论后来被修正，但推动了衰老研究的学科化。", "sources": [ "SRC-024" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "约 1903 年前后是概念推广时间，具体著作需分别核对。", "cross_links": [ "HIT-THT-010" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-THT-010", "title": "纳舍提出“老年医学”一词", "date_start": "1909", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "thought", "claim": "纳舍强调老年患者具有不同于一般成年患者的疾病表现和照护需求。", "summary": "衰老研究逐渐分化为基础老年学和临床老年医学两条路线。", "sources": [ "SRC-025" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "术语沿用与学科制度化过程需要进一步复核。", "cross_links": [ "HIT-THT-009" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-001", "title": "卡雷尔鸡胚心脏组织培养被宣传为“永生细胞”", "date_start": "1912~", "date_type": "approx", "period_id": "period-20th-century", "civilization": "France", "region": "France", "path_family": "maintenance", "event_type": "technology", "claim": "卡雷尔的组织培养被宣传为能够无限生长的“永生细胞”，这一说法后来受到实验方法和持续添加新细胞等问题的质疑。", "summary": "该事件首次把“细胞是否天然会死亡”推到公共科学讨论中心。", "sources": [ "SRC-026" ], "evidence_grade": "L", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "“永生”说法来自宣传和后来争议，不等于实验证据支持细胞天然不死。", "cross_links": [ "HIT-SCI-003" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-LIT-006", "title": "恰佩克《马克洛普洛斯秘方》首演", "date_start": "1922", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Czechoslovakia", "region": "Central Europe", "path_family": "philosophical", "event_type": "literature", "claim": "长寿药使主人公活了三百余年却逐渐失去热情和归属感，把无限寿命可能造成的意义耗损、代际断裂和权力不平等带入现代公共讨论。", "summary": "该剧成为现代“永生反乌托邦”叙事的重要作品。", "sources": [ "SRC-027" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "戏剧首演年份和版本差异需要按戏剧史资料核对。", "cross_links": [ "HIT-LIT-004" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-001", "title": "麦凯报告限制热量摄入延长大鼠寿命", "date_start": "1935-07", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "technology", "claim": "限制大鼠热量摄入能够延长寿命，使延寿研究转向可重复的营养实验。", "summary": "这是较早显示哺乳动物寿命可被实验性干预的研究之一。", "sources": [ "SRC-2596" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "原始 McCay et al. 1935 论文已核验；限制热量实验不能直接外推到人类寿命。", "cross_links": [ "HIT-THT-007" ], "chapter": "老年学、进化论与细胞寿命", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。；日期补齐：Crossref 1935-07 (published-print, month, v3)", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-002", "title": "HeLa 细胞系建立", "date_start": "1951", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "reconstruction", "event_type": "technology", "claim": "HeLa 细胞证明某些癌细胞可以获得近乎无限的体外增殖能力，也明确显示“细胞永生”可能伴随癌变。", "summary": "其未经同意取样的历史引发了持续的研究伦理争议。", "sources": [ "SRC-2602" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "细胞永生与人体永生必须区分；HeLa 的取样和知情同意问题需要独立历史审查。", "cross_links": [ "HIT-SCI-003" ], "chapter": "老年学、进化论与细胞寿命", "notes": "来源纠偏：原 NIH 页面 403，改用可访问的 HeLa 二手百科来源。本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-011", "title": "梅达沃提出突变积累理论", "date_start": "1952", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Britain", "region": "Britain", "path_family": "maintenance", "event_type": "thought", "claim": "自然选择对晚年有害突变的清除能力较弱，由此建立“突变积累”理论。", "summary": "衰老被解释为进化机制的结果，而非为个体安排好的死亡程序。", "sources": [ "SRC-030" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "理论为进化学说，不能单独解释全部衰老机制。", "cross_links": [ "HIT-THT-012" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-002", "title": "哈曼提出衰老自由基理论", "date_start": "1956", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "technology", "claim": "代谢产生的活性分子会不断积累细胞损伤，推动氧化应激和抗氧化剂研究。", "summary": "后来证据表明自由基也能参与正常信号调节，不能单独解释全部衰老。", "sources": [ "SRC-031" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "理论已从单一损伤模型发展为更复杂的氧化还原信号观点。", "cross_links": [ "HIT-SCI-003" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-012", "title": "威廉斯提出拮抗性多效性理论", "date_start": "1957", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "thought", "claim": "某些基因在年轻时提高生存或繁殖优势，却可能在晚年造成损害，因此仍会被自然选择保留。", "summary": "该理论成为解释衰老为何长期存在的主要进化框架之一。", "sources": [ "SRC-032" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "理论解释群体演化，不直接给出个体干预方案。", "cross_links": [ "HIT-THT-011" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-013", "title": "赫胥黎使用“超人类主义”一词", "date_start": "1957", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Britain", "region": "Britain", "path_family": "cognitive_extension", "event_type": "thought", "claim": "赫胥黎主张人类可通过知识和技术超越现有生物限制，把延寿、人体增强、人工智能和意识上传纳入同一未来主义谱系。", "summary": "“超人类主义”由此成为讨论技术性超越的通用标签。", "sources": [ "SRC-033" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该词在不同语境中的定义差异较大，事件只记录 1957 年使用。", "cross_links": [ "HIT-THT-014" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-003", "title": "Hayflick 极限发表", "date_start": "1961-12", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "technology", "claim": "正常人类体细胞只能分裂有限次数，推翻了正常体细胞天然不死的观念。", "summary": "Hayflick 和 Moorhead 把细胞衰老、染色体末端和癌细胞无限增殖联系起来。", "sources": [ "SRC-2598" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "细胞分裂极限不等于个体寿命极限；端粒、衰老细胞和癌变之间的因果链仍需分别审查。", "cross_links": [ "HIT-TEC-002", "HIT-SCI-005" ], "chapter": "老年学、进化论与细胞寿命", "notes": "来源纠偏：改用 Hayflick & Moorhead 1961 原始论文。本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。；日期补齐：Crossref 1961-12 (published-print, month, v3)", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-PRA-007", "title": "埃廷格提出并出版《永生的前景》", "date_start": "1962~", "date_end": "1964~", "date_type": "range", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "suspension", "event_type": "practice", "claim": "埃廷格提出在人被依法宣告死亡后迅速低温保存身体或大脑，等待未来医学修复。", "summary": "该方案推动了现代人体冷冻运动形成，但仍依赖尚未得到验证的未来复苏假设。", "sources": [ "SRC-035" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "1962 年前后完成写作、1964 年正式出版，冷冻复苏至今未被验证。", "cross_links": [ "HIT-TEC-003" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。" }, { "event_id": "HIT-TEC-003", "title": "贝德福德接受人体冷冻保存", "date_start": "1967", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "California", "path_family": "suspension", "event_type": "technology", "claim": "贝德福德在死亡后接受低温保存，通常被视为第一个以未来复苏为目标进行人体冷冻的人。", "summary": "该事件使冷冻主义从理论倡议转化为实际服务，并确立法律死亡、生物死亡和信息不可逆丧失之间的争议。", "sources": [ "SRC-036" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "“第一个”表述依赖传记和媒体记录；复苏仍属未验证假设。", "cross_links": [ "HIT-PRA-007" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-001", "title": "美国国会设立国家老龄研究所", "date_start": "1974", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "United States", "path_family": "maintenance", "event_type": "institution", "claim": "老年研究由分散的实验室项目上升为长期公共科研制度。", "summary": "NIA 研究范围覆盖衰老机制、老年疾病、行为、社会和经济问题。", "sources": [ "SRC-037" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "机构设立年份与立法细节以官方机构史为准。", "cross_links": [ "HIT-INS-003" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-004", "title": "秀丽隐杆线虫长寿突变株被发现", "date_start": "1983-07", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Laboratory", "path_family": "maintenance", "event_type": "technology", "claim": "单个或少数基因的变化也可能显著影响寿命，为寻找保守衰老通路打开道路。", "summary": "较早的长寿突变表明寿命并非只能由无数微小因素决定。", "sources": [ "SRC-2597" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "major", "uncertainty": "Klass 1983 原始论文已核验；单基因长寿突变不等于普适长寿机制。", "cross_links": [ "HIT-SCI-006" ], "chapter": "低温保存、分子机制与数字永生", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。；日期补齐：Crossref 1983-07 (published-print, month, v3)", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-SCI-005", "title": "格雷德与布莱克本发现端粒酶活性", "date_start": "1984", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "Laboratory", "path_family": "maintenance", "event_type": "technology", "claim": "端粒与端粒酶研究解释了染色体末端保护、细胞有限分裂和癌细胞持续增殖之间的联系。", "summary": "激活端粒酶可能增加癌症风险，并非简单的“永生开关”。", "sources": [ "SRC-039" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "官方科普页可支持发现与后续奖项，但原始实验细节需按论文核对。", "cross_links": [ "HIT-SCI-003", "HIT-INS-002" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-014", "title": "莫拉维克出版《心智儿童》", "date_start": "1988", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "United States", "path_family": "digital_migration", "event_type": "thought", "claim": "莫拉维克系统设想将人类心智的信息结构转移到机器载体，使“永生”对象从身体转向记忆、计算模式和人格信息。", "summary": "上传后的副本是否仍是原本人，成为个人同一性哲学中的核心难题。", "sources": [ "SRC-040" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该书是思想设想而非技术实现或人格连续性证明。", "cross_links": [ "HIT-THT-013" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-006", "title": "凯尼恩团队发现 daf-2 调控线虫寿命", "date_start": "1993", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "Laboratory", "path_family": "maintenance", "event_type": "technology", "claim": "改变秀丽隐杆线虫 daf-2 基因可使其寿命约增加一倍，且效果依赖 daf-16。", "summary": "胰岛素样信号通路能够系统调控衰老，使衰老生物学进入基因和信号网络阶段。", "sources": [ "SRC-041" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "线虫结果不能直接外推人类寿命。", "cross_links": [ "HIT-SCI-004" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-DEM-002", "title": "卡尔芒创下验证性最长寿命纪录", "date_start": "1997", "date_type": "approx", "period_id": "period-20th-century", "civilization": "France", "region": "France", "path_family": "maintenance", "event_type": "demographic", "claim": "让娜·卡尔芒以 122 岁 164 天去世，其年龄记录经过较完整的文件验证，至今仍是公认的人类最长寿纪录。", "summary": "该个案是研究极端寿命的重要基准，但不证明寿命可以无限增长。", "sources": [ "SRC-042" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "极端纪录验证受文件完整性和人口学方法影响。", "cross_links": [ "HIT-DEM-001", "HIT-SCI-013" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-007", "title": "山中伸弥团队建立诱导多能干细胞", "date_start": "2006", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Japan", "region": "Laboratory", "path_family": "reconstruction", "event_type": "technology", "claim": "成熟小鼠体细胞可被重编程为诱导多能干细胞，说明细胞身份和部分年龄相关表观遗传状态具有可逆性。", "summary": "该技术成为“细胞年轻化”和部分重编程研究的重要基础。", "sources": [ "SRC-043" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "iPS 技术不直接等于人体返老还童；肿瘤风险与身份稳定性仍需治理。", "cross_links": [ "HIT-SCI-011" ], "chapter": "低温保存、分子机制与数字永生", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-008", "title": "雷帕霉素延长小鼠寿命研究发表", "date_start": "2009", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Laboratory", "path_family": "maintenance", "event_type": "technology", "claim": "从较晚年龄开始给予雷帕霉素仍能延长小鼠寿命，使 mTOR 通路成为药物干预衰老的重要对象。", "summary": "免疫抑制、代谢副作用和人体剂量问题限制了直接应用。", "sources": [ "SRC-044" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "小鼠结果不能直接作为人体延寿证据。", "cross_links": [ "HIT-SCI-012" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-002", "title": "端粒及端粒酶研究获诺贝尔奖", "date_start": "2009", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Sweden", "region": "Stockholm", "path_family": "maintenance", "event_type": "institution", "claim": "布莱克本、格雷德和绍斯塔克因端粒及端粒酶研究获得诺贝尔生理学或医学奖。", "summary": "该奖项确认细胞衰老机制已成为主流生命科学问题，也帮助区分细胞复制寿命、癌症与个体寿命。", "sources": [ "SRC-039" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "奖项事件是制度事实；是否支持长寿干预需单独审查。", "cross_links": [ "HIT-SCI-005" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-003", "title": "NIH 建立跨研究所老年科学兴趣组", "date_start": "2012", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "United States", "path_family": "maintenance", "event_type": "institution", "claim": "老年科学主张研究作为共同风险基础的衰老机制，而不是分别治疗多种年龄相关疾病。", "summary": "该兴趣组推动衰老干预进入公共科研议程。", "sources": [ "SRC-045" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "机构事件以官方页面为准。", "cross_links": [ "HIT-INS-004" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-004", "title": "首届 NIH 老年科学峰会举行", "date_start": "2013", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "United States", "path_family": "maintenance", "event_type": "institution", "claim": "会议推动“以衰老为共同危险因素”的研究框架进入公共科研议程。", "summary": "衰老干预从边缘性延寿理想转向慢性病预防和健康寿命政策。", "sources": [ "SRC-046" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "会议影响和后续政策转化需要结合史料评估。", "cross_links": [ "HIT-INS-003" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-015", "title": "《衰老的标志》提出九项统一框架", "date_start": "2013", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Biogerontology", "path_family": "maintenance", "event_type": "thought", "claim": "九项衰老标志为高度分散的衰老机制建立统一框架，成为研究、投资和药物开发的重要路线图。", "summary": "该框架包含基因组不稳定、端粒、表观遗传、蛋白稳态、营养感知、线粒体、细胞衰老、干细胞和通讯改变。", "sources": [ "SRC-038" ], "evidence_grade": "I", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "标志之间存在重叠，部分因果关系尚不清楚。", "cross_links": [ "HIT-THT-016" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-009", "title": "霍瓦特发表 DNA 甲基化表观遗传时钟", "date_start": "2013", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Laboratory", "path_family": "maintenance", "event_type": "technology", "claim": "研究者开始尝试用分子指标衡量生物年龄和干预反应。", "summary": "表观遗传时钟成为生物年龄建模的重要入口。", "sources": [ "SRC-047" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "时钟数值变化是否必然对应疾病减少或寿命延长，仍需长期临床终点验证。", "cross_links": [ "HIT-SCI-014" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-010", "title": "达沙替尼与槲皮素清除衰老细胞研究发表", "date_start": "2015", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Laboratory", "path_family": "maintenance", "event_type": "technology", "claim": "达沙替尼与槲皮素组合能够选择性清除部分衰老细胞，推动“衰老细胞清除剂”概念形成。", "summary": "后续小鼠研究显示改善身体功能和一定的寿命效应，但人体安全性、选择性和长期获益未充分确认。", "sources": [ "SRC-048" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "人体转化、长期风险和选择性仍待临床试验。", "cross_links": [ "HIT-SCI-012" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-POL-001", "title": "WHO 发布《世界老龄化与健康报告》", "date_start": "2015", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Global", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "政策重点由单纯提高平均寿命转向维持功能能力、环境支持和健康寿命。", "summary": "公共卫生体系并不把无限延寿作为首要目标。", "sources": [ "SRC-049" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "报告是政策文本，不代表科学证明寿命可无限延长。", "cross_links": [ "HIT-POL-002" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-011", "title": "周期性部分山中因子重编程改善早衰小鼠", "date_start": "2016", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Laboratory", "path_family": "reconstruction", "event_type": "technology", "claim": "周期性表达部分山中因子改善若干衰老表型并延长早衰模型小鼠寿命。", "summary": "该结果推动“部分重编程”成为细胞年轻化热点，但完全重编程可能导致身份丧失、畸胎瘤或癌变。", "sources": [ "SRC-050" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "小鼠模型结果与人体安全窗口之间仍有巨大距离。", "cross_links": [ "HIT-SCI-007" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-POL-002", "title": "联合国健康老龄化十年启动", "date_start": "2021", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Global", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "联合国“健康老龄化十年（2021-2030）”由世界卫生组织牵头，强调延长健康和自主生活而非单纯增加生存年数。", "summary": "老龄化被视为医疗、照护、城市环境和社会公平问题。", "sources": [ "SRC-051" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "政策目标与科学实现之间需要分别判断。", "cross_links": [ "HIT-POL-001" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-005", "title": "Altos Labs 正式启动", "date_start": "2022", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "institution", "claim": "Altos Labs 宣布获得约 30 亿美元资金承诺，重点研究细胞健康、应激恢复力和细胞年轻化。", "summary": "衰老研究成为大型私人资本和产业组织介入的领域，但不等于已经拥有逆转人体衰老的方法。", "sources": [ "SRC-052" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "企业目标是探索可转化的细胞修复技术；资金承诺不等于临床疗效。", "cross_links": [ "HIT-SCI-011" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-016", "title": "《衰老的标志》扩展为十二项", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Biogerontology", "path_family": "maintenance", "event_type": "thought", "claim": "更新版框架加入宏观自噬障碍、慢性炎症和菌群失调等内容，反映衰老研究从单细胞机制转向器官、免疫和微生态网络。", "summary": "扩展同时引发批评：标志之间存在重叠，部分因果关系尚不清楚。", "sources": [ "SRC-053" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "模型动物寿命结果未必适用于人类。", "cross_links": [ "HIT-THT-015" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-012", "title": "抑制 IL-11 信号延长老龄小鼠健康寿命", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Laboratory", "path_family": "maintenance", "event_type": "technology", "claim": "抑制白细胞介素-11 信号可改善老龄小鼠多项健康指标，并使中位寿命提高约两成。", "summary": "炎症信号被列为潜在干预靶点，但结果仍是小鼠实验。", "sources": [ "SRC-054" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "不能据此判断人体寿命会获得相同幅度增长。", "cross_links": [ "HIT-SCI-008", "HIT-SCI-010" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-013", "title": "人口学分析质疑本世纪激进寿命延长", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "demographic", "claim": "在现有死亡率改善趋势下，本世纪实现激进的人类寿命延长并不可信，除非生物衰老速度本身被显著降低。", "summary": "传统医疗进步带来的寿命增长正在遭遇递减效应。", "sources": [ "SRC-055" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该分析不是对未来技术可能性的绝对否定。", "cross_links": [ "HIT-DEM-002" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-014", "title": "跨物种哺乳动物衰老与死亡风险转录特征发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Laboratory", "path_family": "maintenance", "event_type": "technology", "claim": "研究者整合四种哺乳动物、二十五种以上组织和超过一万一千份转录组数据，提出跨物种的衰老与死亡风险转录特征。", "summary": "该研究显示炎症、线粒体、染色质和细胞外基质等模块在哺乳动物中具有一定保守性。", "sources": [ "SRC-056" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "转录特征仍是关联性模型，不等同于因果干预靶点。", "cross_links": [ "HIT-SCI-009" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-DEM-003", "title": "截至 2026 年人类永生证据状态盘点", "date_start": "2026-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Global", "region": "Global", "path_family": "cross_path", "event_type": "thought", "claim": "公开且可验证的证据尚未显示人类已经实现停止衰老、显著逆转全身生物年龄、冷冻复苏或意识上传。", "summary": "现代研究获得的是模式生物延寿、部分细胞状态重置、疾病风险降低和生物标志物变化；与人类永生之间仍存在巨大证据和工程距离。", "sources": [ "SRC-057" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "这是截至 2026 年 8 月的证据状态，未来文献可能改变结论。", "cross_links": [ "HIT-SCI-013" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核；该事件是证据盘点而非实现事件。" }, { "event_id": "HIT-MTH-005", "title": "帕埃斯图姆神殿蜂蜜残留被解释为不朽象征", "date_start": "-530~", "date_end": "-510~", "date_type": "range", "period_id": "period-archaic-mediterranean", "civilization": "Mediterranean civilizations", "region": "Paestum, Italy", "path_family": "philosophical", "event_type": "religious", "claim": "帕埃斯图姆神殿青铜罐中发现蜂蜜残留，研究者将其解释为以蜂蜜象征不朽的仪式证据。", "summary": "这是永生追问具有考古物证的早期案例，说明不朽象征并非现代建构。", "sources": [ "SRC-059" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "蜂蜜残留是考古事实，其“不朽象征”属于研究者的仪式解释。", "cross_links": [ "HIT-MTH-001" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft；论文实测年代为公元前 530-510 年，底稿旧写的约公元前 2000 年应被本事件取代。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-MTH-006", "title": "提托诺斯神话形成“永生而无青春”母题", "date_start": "-700~", "date_type": "approx", "period_id": "period-archaic-greece", "civilization": "Ancient Greece", "region": "Aegean world", "path_family": "philosophical", "event_type": "myth", "claim": "黎明女神厄俄斯为提托诺斯求得永生却忘记求青春，使其永远衰老，成为“无效永生”的早期反例。", "summary": "该母题把活得久与活得好区分开，成为后来有效永生讨论的文学原型。", "sources": [ "SRC-060" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "神话文本形成于口传传统，约公元前 7-6 世纪为参考窗口。", "cross_links": [ "HIT-LIT-003", "HIT-LIT-004" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-MTH-007", "title": "嫦娥奔月与西王母不死药母题形成", "date_start": "-200~", "date_type": "approx", "period_id": "period-warring-states-han", "civilization": "China", "region": "Central China", "path_family": "philosophical", "event_type": "myth", "claim": "西王母持有不死药、后羿求药、嫦娥窃药奔月的故事被纳入汉代文本，成为中文世界“不死药”母题的文学源头。", "summary": "该母题把永生追求与药物、女性、月宫和失散叙事结合，影响此后丹药与修仙文学。", "sources": [ "SRC-061" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "口传故事早于汉代文本，约公元前 2 世纪只能代表文本化节点。", "cross_links": [ "HIT-PRA-001", "HIT-LIT-002" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-THT-017", "title": "《道德经》“死而不亡者寿”与道家长生观形成", "date_start": "-400~", "date_type": "approx", "period_id": "period-warring-states-han", "civilization": "China", "region": "Central China", "path_family": "philosophical", "event_type": "thought", "claim": "早期道家文本用“死而不亡者寿”等表达区分肉体存续与精神延续，把长寿问题引向自然与道的关系。", "summary": "这为后世修仙、养生和“精神不朽”路线提供了中文思想源头。", "sources": [ "SRC-062" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "《道德经》成书年代存在争议，约公元前 4 世纪为常用参考框架。", "cross_links": [ "HIT-THT-004", "HIT-PRA-004" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-THT-018", "title": "贝尔纳提出内环境概念", "date_start": "1865", "date_type": "approx", "period_id": "period-19th-century", "civilization": "France", "region": "Western Europe", "path_family": "maintenance", "event_type": "thought", "claim": "贝尔纳把生物体内环境的稳定维持视为生命的重要条件，为稳态维护成为主体持续性基础提供了概念框架。", "summary": "内环境概念后来发展为生理学和老年科学中的稳态思想。", "sources": [ "SRC-063" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "1865 年对应法文版《实验医学研究导论》，后经翻译传播。", "cross_links": [ "HIT-THT-009" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-019", "title": "鲁布纳提出代谢率与寿命关系理论", "date_start": "1908~", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Germany", "region": "Central Europe", "path_family": "maintenance", "event_type": "thought", "claim": "鲁布纳依据能量代谢与体型数据提出寿命与代谢率关系的早期理论，为能量消耗、体型和寿命建模奠定基础。", "summary": "该理论虽被后续机制修正，却把“能量支出如何变成寿命成本”变成可研究的经验问题。", "sources": [ "SRC-064" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "代谢率与寿命的简单反比关系在现代证据中并不普遍成立。", "cross_links": [ "HIT-DEM-001", "HIT-SCI-002" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-THT-020", "title": "珀尔把寿命决定因素拆分为可研究变量", "date_start": "1921", "date_end": "1925", "date_type": "range", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "thought", "claim": "珀尔在《死亡生物学》及相关研究中系统讨论寿命分布、死亡原因和遗传因素，把寿命从玄学话题转成可分解变量体系。", "summary": "这套“寿命可分解为变量”的思路成为后世所有长寿模型的研究祖先。", "sources": [ "SRC-065" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "公共底稿记为 1925 年，实际著作跨 1921-1925 年，因此使用区间。", "cross_links": [ "HIT-DEM-001", "HIT-SCI-001" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-TEC-004", "title": "人类基因组计划完成", "date_start": "2003", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "人类基因组计划完成，使人类遗传信息第一次获得近乎完整的公开参考序列，成为基因路径与精准长寿研究的基础设施。", "summary": "遗传信息全面可读后，衰老、疾病和个体差异才可能被系统建模。", "sources": [ "SRC-066" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "参考基因组不是每个人的基因组，个体差异和功能解读仍需大量研究。", "cross_links": [ "HIT-SCI-007", "HIT-TEC-005" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-005", "title": "CRISPR 基因编辑进入人体临床试验探索", "date_start": "2016-07-21", "date_end": "2020~", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China / United States", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "CRISPR 从 2016 年起被用于人体细胞改造试验，基因编辑从模式生物进入临床探索阶段。", "summary": "这一阶段证明人体基因改写可以开始被监管性试验，但安全性和疗效仍高度依赖靶点与递送。", "sources": [ "SRC-2601" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "早期试验多为小样本、单靶点探索，不能等同于成熟基因疗法。", "cross_links": [ "HIT-TEC-004", "HIT-TEC-009" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "来源纠偏：改用 Cyranoski Nature 2016 DOI，替代失效跳转链接。本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。；日期补齐：Crossref 2016-07-21 (published-online, day, v3)", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-08T06:21:52Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-TEC-006", "title": "BrainEx 恢复离体猪脑部分循环与细胞功能", "date_start": "2019", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Laboratory", "path_family": "reconstruction", "event_type": "technology", "claim": "BrainEx 系统在离体猪脑中恢复部分微循环、细胞结构和代谢活动，但未恢复代表整体脑功能的全局电活动。", "summary": "该实验把“脑组织仍有细胞活性”与“有意识的人仍在生活”明确区分，成为脑保存研究的重要边界事件。", "sources": [ "SRC-068" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "实验对象是屠宰后猪脑，不等同于复苏或意识恢复。", "cross_links": [ "HIT-TEC-012" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-007", "title": "记忆印迹可被识别并被光遗传激活", "date_start": "2012", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Laboratory", "path_family": "cognitive_extension", "event_type": "technology", "claim": "研究者通过光遗传刺激海马记忆印迹细胞，使小鼠在无原始线索时仍产生恐惧记忆唤起，显示记忆具有可定位的神经基质。", "summary": "该工作把记忆编辑和身份连续性从哲学设想推进到可干预实验。", "sources": [ "SRC-069" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "小鼠印迹实验不等于人类记忆可上传或可安全编辑。", "cross_links": [ "HIT-TEC-012" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-008", "title": "DishBrain 体外神经元在模拟游戏中学习", "date_start": "2022", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Australia", "region": "Laboratory", "path_family": "digital_migration", "event_type": "technology", "claim": "体外培养的活体神经培养物在模拟游戏环境中被观察到学习信号，展示生物神经基质计算的可能性。", "summary": "该实验是活体神经基质计算的重要早期信号，但“学习”不等于意识或通用智能。", "sources": [ "SRC-070" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "体外学习与人体智能、意识或主体连续性之间仍有巨大距离。", "cross_links": [ "HIT-THT-021" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-021", "title": "类器官智能路线正式提出", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "研究者提出把三维脑类器官作为生物计算平台、建立“类器官智能”路线的研究议程。", "summary": "该路线把数字迁移问题从软件仿真扩展到活体生物计算支线，但伦理与工程门槛极高。", "sources": [ "SRC-071" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "类器官智能仍是路线倡议，不构成现有人工智能或意识替代。", "cross_links": [ "HIT-TEC-008" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-009", "title": "基因编辑猪心脏首次移植人体", "date_start": "2022", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Maryland", "path_family": "reconstruction", "event_type": "technology", "claim": "一名终末期心脏病患者接受基因编辑猪心脏移植，成为异种移植替代人体器官的首次公开人体尝试。", "summary": "患者存活约两个月，结果既显示替换路径进入人体阶段，也记录感染、免疫和长期存活等严重风险。", "sources": [ "SRC-072" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "单例、同情使用、长期存活失败，不能代表异种移植已成熟。", "cross_links": [ "HIT-TEC-010" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-010", "title": "基因编辑猪肾移植进入人体探索", "date_start": "2023", "date_end": "2024", "date_type": "range", "period_id": "period-21st-century", "civilization": "United States", "region": "New York / Massachusetts", "path_family": "reconstruction", "event_type": "technology", "claim": "基因编辑猪肾先后被移植入脑死亡患者和活体终末期肾病患者，用于检验异种肾移植的可行性。", "summary": "这延续了“更换部件”路径，但长期免疫、感染、监管和伦理问题仍未解决。", "sources": [ "SRC-073" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "早期人体案例数量和随访时间有限，不能外推为成熟疗法。", "cross_links": [ "HIT-TEC-009" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-TEC-011", "title": "侵入式脑机接口进入人体植入试验", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Clinical trial", "path_family": "cognitive_extension", "event_type": "technology", "claim": "Neuralink 的 PRIME 研究进入首例人体植入试验，代表侵入式脑机接口从动物实验进入受监管人体阶段。", "summary": "脑机接口被用于读取神经信号并控制数字设备，但距离长期、双向、稳定的人机融合仍远。", "sources": [ "SRC-074" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "临床试验尚不能证明长期安全性、疗效或身份连续性收益。", "cross_links": [ "HIT-THT-013", "HIT-THT-021" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-012", "title": "脑保存与连接组竞赛进入技术议程", "date_start": "2016", "date_end": "2022", "date_type": "range", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "脑保存基金会设立保存奖，同时全脑连接组研究完成多类昆虫和局部哺乳动物神经通路重建，使结构保存成为数字迁移路径的前置议题。", "summary": "结构保存是否足以保存人格信息，成为脑保存路线最关键的未决问题。", "sources": [ "SRC-075" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "连接组不等于记忆或意识读出，人脑连接组仍有数量级差距。", "cross_links": [ "HIT-TEC-006", "HIT-TEC-007" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-SCI-015", "title": "硫化氢诱导低代谢“暂停”研究系统化", "date_start": "2005", "date_end": "2014", "date_type": "range", "period_id": "period-21st-century", "civilization": "International", "region": "Laboratory", "path_family": "suspension", "event_type": "technology", "claim": "从动物实验到重症医学综述，研究者系统探索用硫化氢等气体信使诱导可逆低代谢状态，为生物暂停路径提供药理学概念验证。", "summary": "该路线试图为创伤和未来等待“买时间”，但离无损伤的人体暂停仍远。", "sources": [ "SRC-076" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "动物模型向人体外推受限，常温条件下效果弱于低温合用。", "cross_links": [ "HIT-TEC-003", "HIT-SCI-016" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-SCI-016", "title": "脱水休眠成为生物暂停机制研究模型", "date_start": "2025", "date_end": "2026", "date_type": "range", "period_id": "period-21st-century", "civilization": "International", "region": "Laboratory", "path_family": "suspension", "event_type": "technology", "claim": "缓步动物等脱水休眠研究被系统纳入衰老与长寿机制分析，探讨代谢暂停、自噬与恢复的关系。", "summary": "这为“暂停-恢复”提供生物学参照，但物种间外推极其有限。", "sources": [ "SRC-077" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "模式生物机制不能直接指向人体冷冻或冬眠可行性。", "cross_links": [ "HIT-SCI-015" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-THT-022", "title": "FM-2030 推广“超人类”概念", "date_start": "1990~", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "FM-2030 通过著作与活动普及“超人类”概念，把技术增强、长寿和人格转型纳入大众思想运动。", "summary": "这使超人类主义从边缘术语变成可识别的社会思想标签。", "sources": [ "SRC-078" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "公共底稿记为 1990 年，具体出版年份在不同书目中存在差异。", "cross_links": [ "HIT-THT-013" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-INS-006", "title": "世界超人类主义协会成立", "date_start": "1998", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "世界超人类主义协会成立，后发展为 Humanity+，使超人类主义思想获得正式组织载体。", "summary": "思想运动由此进入制度化阶段，并连接长寿、增强、AI 和数字迁移等议题。", "sources": [ "SRC-079" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "组织名称和治理结构在后续年份多次调整。", "cross_links": [ "HIT-THT-022" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-007", "title": "永生研究所成立", "date_start": "2002", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "永生研究所作为面向研究、教育和社区协作的在线组织成立，把“永生主义”从个人信念转为有组织的知识社区。", "summary": "它成为永生主义运动的重要组织核心之一。", "sources": [ "SRC-080" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "组织活动和影响力随时间波动，站点历史需通过归档资料复核。", "cross_links": [ "HIT-THT-023" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-023", "title": "德格雷系统提出衰老工程修复与长寿逃逸速度", "date_start": "2007", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United Kingdom / United States", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "德格雷在《终结衰老》中把衰老拆成七类可修复损伤，并普及“长寿逃逸速度”概念，把延寿重新定义为工程问题。", "summary": "该框架推动公共讨论从“抗衰老药物”转向“损伤维护与重建”的系统工程。", "sources": [ "SRC-081" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "七类损伤和修复路线是研究纲领，不等于已有人体重建能力。", "cross_links": [ "HIT-SCI-007", "HIT-SCI-011" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-024", "title": "库兹韦尔出版《奇点临近》", "date_start": "2005", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cross_path", "event_type": "thought", "claim": "库兹韦尔在《奇点临近》中把加速回报、意识上传和 2045 年奇点时间表带入公众视野。", "summary": "该书成为数字迁移与未来主义叙事的公共峰值，也推动了对技术预测证据边界的讨论。", "sources": [ "SRC-082" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "该书属于预测性思想作品，不构成已验证科学结论。", "cross_links": [ "HIT-THT-014", "HIT-THT-023" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-PRA-008", "title": "Blueprint 启动个人量化长寿工程", "date_start": "2021", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "maintenance", "event_type": "practice", "claim": "布莱恩·约翰逊公开启动 Blueprint，用饮食、运动、睡眠、补剂和持续检测构成个人量化长寿工程。", "summary": "它把“个人健康手册化”变成高可见度的实践案例，但个体方案不能被普遍化为医学建议。", "sources": [ "SRC-083" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "单一个案的方案、资源和测量体系不可外推为普遍长寿证据。", "cross_links": [ "HIT-SCI-008", "HIT-DEM-003" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-FAI-002", "title": "苦杏仁苷抗癌宣称被证伪", "date_start": "1970", "date_end": "1979", "date_type": "range", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "cross_path", "event_type": "failure", "claim": "以“天然抗癌”为卖点的苦杏仁苷缺乏有效证据，并存在氰化物中毒风险，最终被监管机构禁止销售。", "summary": "它成为“天然不等于有效”的典型失败教训。", "sources": [ "SRC-084" ], "evidence_grade": "L", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "监管史和临床试验记录需按具体年份分别复核。", "cross_links": [ "HIT-FAI-001", "HIT-FAI-003" ], "chapter": "失败与教训", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-FAI-003", "title": "生长激素“返老还童”滥用成为监管教训", "date_start": "1990", "date_end": "1999", "date_type": "range", "period_id": "period-20th-century", "civilization": "United States / Global", "region": "Global", "path_family": "maintenance", "event_type": "failure", "claim": "生长激素和睾酮被广泛当作“返老还童”补品使用，但过量使用带来关节、代谢和肿瘤风险，缺乏充分的抗衰证据。", "summary": "这显示激素干预必须区分医学替代、健康人群抗衰和商业滥用。", "sources": [ "SRC-085" ], "evidence_grade": "L", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "不同激素、剂量和人群的风险收益差异很大，本事件只记录滥用模式。", "cross_links": [ "HIT-FAI-001", "HIT-FAI-002" ], "chapter": "失败与教训", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-FAI-004", "title": "未经批准干细胞诊所商业化扩张", "date_start": "2000", "date_end": "2020", "date_type": "range", "period_id": "period-21st-century", "civilization": "Global", "region": "Global", "path_family": "reconstruction", "event_type": "failure", "claim": "大量机构在缺乏批准和疗效证据的情况下销售干细胞治疗，造成伤害、费用损失和监管风险。", "summary": "商业化跑在证据前面，是再生医学路径最重要的监管教训之一。", "sources": [ "SRC-086" ], "evidence_grade": "L", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "并非所有干细胞应用都不合规；本事件只针对未经批准的商业营销。", "cross_links": [ "HIT-TEC-009", "HIT-FAI-006" ], "chapter": "失败与教训", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-06T09:30:00Z" }, { "event_id": "HIT-FAI-005", "title": "“人头移植”宣称引发科学与伦理争议", "date_start": "2017", "date_type": "approx", "period_id": "period-21st-century", "civilization": "China / Italy", "region": "Harbin / Turin", "path_family": "reconstruction", "event_type": "failure", "claim": "相关团队宣称完成人头移植，实际公开内容为尸体手术，既没有恢复意识或主体连续性，也引发强烈伦理质疑。", "summary": "该事件成为把“手术奇观”包装成“生命延续”的失败案例。", "sources": [ "SRC-087" ], "evidence_grade": "L", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "不同报道对“成功”的定义差异极大，正式论文和可复核证据不足。", "cross_links": [ "HIT-TEC-009", "HIT-FAI-004" ], "chapter": "失败与教训", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-FAI-006", "title": "FDA 警告年轻血浆抗衰商业化", "date_start": "2019", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "failure", "claim": "美国 FDA 对向健康消费者销售年轻血浆输注以“抗衰老”的未批准治疗发出警告，强调缺乏有效性和安全性证据。", "summary": "这延续了“年轻血液”母题的现代监管失败记录。", "sources": [ "SRC-088" ], "evidence_grade": "L", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "血浆研究仍在进行，警告针对未经批准的商业用途，不否定全部科研。", "cross_links": [ "HIT-FAI-002", "HIT-FAI-004" ], "chapter": "失败与教训", "notes": "draft，等待来源语境复核。", "created_at": "2026-08-06T09:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-008", "title": "XPRIZE Healthspan 全球竞赛启动", "date_start": "2023-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Global / United States", "region": "Global / New York", "path_family": "maintenance", "event_type": "institution", "claim": "XPRIZE 于 2023 年 11 月启动 1.01 亿美元、为期 7 年的 Healthspan 竞赛，要求参赛者开发可恢复 50—80 岁人群肌肉、认知和免疫功能至少 10 年、目标 20 年的治疗，以缩短寿命与健康寿命之间的差距。", "summary": "该竞赛把健康寿命恢复能力转化为全球性可测量挑战，并吸引 Hevolution 等机构共同资助。", "sources": [ "SRC-089", "SRC-090" ], "evidence_grade": "S", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "竞赛目标和奖励机制仍在演化，结果不能等同于已验证疗法。", "cross_links": [ "HIT-INS-005", "HIT-POL-002" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-07T15:52:34Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-INS-009", "title": "Hevolution 基金会成立", "date_start": "2021", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Saudi Arabia / Global", "region": "Riyadh / Global", "path_family": "social_composite", "event_type": "institution", "claim": "Hevolution 于 2021 年成立，定位为全球非营利基金会，通过资助和早期投资推动健康寿命科学，总部位于利雅得。", "summary": "Hevolution 成为健康寿命产业中规模较大的资金与基础设施角色，后成为 XPRIZE Healthspan 共同冠名赞助方。", "sources": [ "SRC-097", "SRC-090" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "预算规模、拨款落实和实际资助效果需要逐年核验。", "cross_links": [ "HIT-INS-008", "HIT-INS-005" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做官方关于页可达性核验。", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-010", "title": "XPRIZE Healthspan 公布首批里程碑获奖者", "date_start": "2025-05-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Global / United States", "region": "Global / New York", "path_family": "maintenance", "event_type": "institution", "claim": "XPRIZE 公布首批里程碑获奖者：超过 600 支来自 58 个国家的参赛队伍，100 支进入半决赛，40 支健康寿命队伍各获 25 万美元，8 支入围 FSHD 奖金赛决赛。", "summary": "首批获奖把健康寿命竞赛从报名阶段推进到方案筛选和临床测试准备阶段。", "sources": [ "SRC-089" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "获奖方案尚未产生人体疗效证据；进入下一阶段不等于干预有效。", "cross_links": [ "HIT-INS-008", "HIT-SCI-019" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做官方新闻稿可达性核验。", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-06T10:12:24.981046Z" }, { "event_id": "HIT-SCI-017", "title": "LEV 基金会 Robust Mouse Rejuvenation 首轮研究公布最终结果", "date_start": "2025-05-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "reconstruction", "event_type": "practice", "claim": "LEV 基金会于 2025 年 5 月 31 日发布首轮 Robust Mouse Rejuvenation 最终更新：最后一只小鼠于 2025 年 2 月 12 日死亡，研究从 2023 年初开始，结果显示损伤修复类处理对中年起始小鼠寿命具有可叠加影响，但幅度与热量限制及模拟物相当，被称为“限定性胜利”。", "summary": "这是以组合干预测试衰老可塑性的重要公开项目节点，也显示单一组合研究需要与热量限制等基线比较。", "sources": [ "SRC-091", "SRC-092" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "major", "uncertainty": "结果为小鼠研究，且基金会自述“限定性胜利”，尚无人体验证。", "cross_links": [ "HIT-THT-023", "HIT-SCI-008" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-06T10:12:24.981046Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-SCI-018", "title": "TAME 老年科学试验设计公开", "date_start": "2017-06-30", "date_end": "2018-11-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "practice", "claim": "TAME 设计以约 3000 名 65—79 岁受试者为目标，使用二甲双胍与安慰剂对照，并以多种年龄相关疾病复合终点作为主要结局，代表老年科学从动物研究转向大规模人体验证的监管范式探索。", "summary": "TAME 的重要性不在二甲双胍本身，而在把“衰老作为可干预共同风险”引入大型临床试验设计。", "sources": [ "SRC-093", "SRC-094" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "会议摘要记录的是设计阶段；正式启动、完成和结果需另核验。", "cross_links": [ "HIT-INS-004", "HIT-SCI-008" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PMC 协议摘要可达性核验。；日期补齐：Crossref 2017-06-30 (published-online, day, v3)", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-08T06:28:04Z" }, { "event_id": "HIT-SCI-019", "title": "DunedinPACE 衰老速度表观遗传标志物发表", "date_start": "2022-01-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "New Zealand / United States", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "Belsky 等人 2022 年 1 月 14 日在 eLife 发表 DunedinPACE，从血液 DNA 甲基化估算衰老速度，提供比静态年龄更接近干预反馈的健康风险指标。", "summary": "DunedinPACE 成为健康寿命研究中的重要反馈指标，但属于预测关联工具，不能单独证明干预延寿。", "sources": [ "SRC-095" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "major", "uncertainty": "表观遗传衰老速度降低不必然等于发病率或死亡风险下降。", "cross_links": [ "HIT-SCI-009", "HIT-SCI-014" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-06T10:12:24.981046Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-TEC-013", "title": "OpenAI 与 Retro Biosciences 公布 AI 设计增强版山中因子", "date_start": "2025-08-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "OpenAI 于 2025 年 8 月 22 日公布与 Retro Biosciences 的合作：GPT-4b micro 重设计 SOX2 和 KLF4，在体外将干细胞重编程标志物表达提高 50 倍以上，并增强 DNA 损伤修复。", "summary": "该事件显示 AI 开始参与重编程因子设计，但它仍是体外研究，不构成人体重编程疗效。", "sources": [ "SRC-096" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "50 倍表达提高为体外指标；未报告人体安全性、长期功能和临床终点。", "cross_links": [ "HIT-SCI-007", "HIT-SCI-011" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-06T10:12:24.981046Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-TEC-014", "title": "Life Biosciences ER-100 获 FDA IND 批准", "date_start": "2026-01-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America", "path_family": "reconstruction", "event_type": "technology", "claim": "Life Biosciences 宣布 FDA 于 2026 年 1 月 28 日批准 ER-100 的 IND 申请；公司称这是首个使用部分表观遗传重编程进入人体临床的细胞年轻化疗法，拟用于青光眼和 NAION 等视神经病。", "summary": "ER-100 进入 Phase 1，标志山中因子谱系从细胞和动物研究进入人体安全性验证阶段。", "sources": [ "SRC-100", "SRC-101" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "公司声明需独立核验；IND 批准只允许开展安全性试验，不证明疗效。", "cross_links": [ "HIT-SCI-007", "HIT-SCI-011" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-06T10:12:24.981046Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-PRA-009", "title": "ER-100 完成首例受试者给药", "date_start": "2026-06-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America", "path_family": "reconstruction", "event_type": "practice", "claim": "Life Biosciences 宣布 ER-100 Phase 1 完成首例受试者给药，评估其在开角型青光眼和 NAION 中的安全性、耐受性和视觉功能终点。", "summary": "这是人体一期试验的执行节点，仍需长期随访和结果公布。", "sources": [ "SRC-102", "SRC-101" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "major", "uncertainty": "首例给药不等于完成或有效。", "cross_links": [ "HIT-TEC-014" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-06T10:12:24.981046Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-PRA-010", "title": "Loyal LOY-002 完成 FDA 条件批准安全性与有效性要求", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "practice", "claim": "Loyal 官网称截至 2025 年 12 月，LOY-002 已完成 FDA 条件批准所需三大要求中的安全性和有效性要求，该药物面向 10 岁以上犬只，旨在延长健康寿命。", "summary": "犬类长寿药路径可缩短哺乳动物临床反馈周期，但兽医审批结果不能直接转化为人类疗效。", "sources": [ "SRC-099" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该表述来自公司官网，正式批准和最终标签仍需 FDA 决定。", "cross_links": [], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 Internet Archive 快照核验公司页面。", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-06T10:12:24.981046Z" }, { "event_id": "HIT-POL-003", "title": "ARPA-H 启动 PROSPR 健康寿命项目", "date_start": "2024-12-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "policy", "claim": "ARPA-H 于 2024 年 12 月 19 日宣布启动 PROSPR，即 Proactive Solutions for Prolonging Resilience，目标是识别衰老相关标记、开发居家数据采集和三年内完成健康寿命结局评估的临床协议。", "summary": "PROSPR 尝试把健康寿命干预从数十年研究周期压缩为可快速验证的公共资助项目。", "sources": [ "SRC-098" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "项目处于公共资助启动阶段，三年评估协议能否实现需后续结果验证。", "cross_links": [ "HIT-POL-002", "HIT-INS-004" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 ARPA-H 官方项目页可达性核验。", "created_at": "2026-08-06T10:12:24.981046Z", "updated_at": "2026-08-06T10:12:24.981046Z" }, { "event_id": "HIT-TEC-015", "title": "醛稳定低温保存方法发表", "date_start": "2015-09-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "McIntyre/Song 和 Fahy 于 2015 年发表醛稳定低温保存方法，先灌注戊二醛固定突触结构，再灌注玻璃化保护剂并低温保存，目标是长期保存大脑连接组。", "summary": "该方法成为脑保存基金会大奖的技术基础，但保存结构不等于未来可复苏或意识上传。", "sources": [ "SRC-103" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "论文证明结构保存，不证明信息读出、修复或主体恢复。", "cross_links": [ "HIT-TEC-012" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据和 BPF 评价页核验。", "created_at": "2026-08-06T10:25:45.092015Z", "updated_at": "2026-08-06T10:25:45.092015Z" }, { "event_id": "HIT-TEC-016", "title": "脑保存基金会大奖由醛稳定低温保存技术获得", "date_start": "2018-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "脑保存基金会于 2018 年 3 月宣布，21 世纪医学公司用醛稳定低温保存技术保住整颗猪脑的突触连接组，赢得大型哺乳动物脑保存奖 8 万美元奖金。", "summary": "该事件把“可长期保存大脑连接组”从实验室论文转化为公开大奖成果，但获奖对象是死后猪脑，不是复苏或意识证明。", "sources": [ "SRC-104", "SRC-105" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "大奖按结构保存标准评判，不涉及记忆读出或未来复苏。", "cross_links": [ "HIT-TEC-012", "HIT-TEC-015" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 BPF 公告页和 Nectome 存档核验。", "created_at": "2026-08-06T10:25:45.092015Z", "updated_at": "2026-08-06T10:25:45.092015Z" }, { "event_id": "HIT-TEC-017", "title": "OrganEx 恢复死后猪体部分细胞与分子功能", "date_start": "2022-08-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Laboratory", "path_family": "reconstruction", "event_type": "technology", "claim": "耶鲁团队 2022 年在 Nature 报告 OrganEx，在猪全身停血一小时后恢复多个重要器官的组织完整性、降低细胞死亡并恢复部分细胞和分子过程。", "summary": "OrganEx 把 BrainEx 思路从离体猪脑扩展到全身，显示死后早期恢复部分细胞功能的潜力，但不等于全身复苏或意识恢复。", "sources": [ "SRC-106" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "恢复的是细胞和分子层面功能，不是整体生命或神经意识。", "cross_links": [ "HIT-TEC-006", "HIT-TEC-015" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Nature 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:25:45.092015Z", "updated_at": "2026-08-06T10:25:45.092015Z" }, { "event_id": "HIT-TEC-018", "title": "果蝇全脑连接组与多连接组细胞分型发布", "date_start": "2024-10-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "technology", "claim": "Schlegel 等人 2024 年在 Nature 发布果蝇全脑注释和多连接组细胞分型，使完整脑连接组重建在模式生物中达到可比较、可复用的规模。", "summary": "该成果推进“连接组能否承载足够主体信息”的技术路线，但果蝇与人类大脑仍有数量级差距。", "sources": [ "SRC-107" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "连接组图谱不等同于记忆或人格读出，也不支持人类意识上传。", "cross_links": [ "HIT-TEC-012", "HIT-TEC-016" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Nature 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:25:45.092015Z", "updated_at": "2026-08-06T10:25:45.092015Z" }, { "event_id": "HIT-SCI-020", "title": "动态人类数字孪生用于生命周期健康建模", "date_start": "2022-09-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Netherlands / International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "Mulder 等人 2022 年在 JMIR 提出动态人类数字孪生，用个体生命周期数据支持诊断、治疗、预测和预防，把主体状态建模与医疗决策连接起来。", "summary": "数字孪生把“人”变成可模拟、可预测、可干预的数据对象，但模型不能替代真实临床决策。", "sources": [ "SRC-108" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该框架仍是研究概念，未证明能实时完整表征个体主体。", "cross_links": [ "HIT-SCI-019" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 JMIR 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:25:45.092015Z", "updated_at": "2026-08-06T10:25:45.092015Z" }, { "event_id": "HIT-THT-025", "title": "Griefbots 数字哀悼与亡者交互进入学术讨论", "date_start": "2022-03-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "Jiménez-Alonso 和 Brescó de Luna 发表 Griefbots 研究，讨论以亡者数据生成聊天机器人进行数字哀悼所涉及的记忆、身份、关系与伦理问题。", "summary": "Griefbots 把“数字化身”“来生技术”从产品概念转化为需要严肃研究的哀悼与身份议题。", "sources": [ "SRC-109" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该文是思想与伦理分析，不等于技术已经能延续主体。", "cross_links": [ "HIT-THT-021", "HIT-TEC-012" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Springer 论文页和 PubMed 元数据核验。", "created_at": "2026-08-06T10:25:45.092015Z", "updated_at": "2026-08-06T10:25:45.092015Z" }, { "event_id": "HIT-THT-026", "title": "脑机接口伦理问题系统化综述发表", "date_start": "2017-11-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "Burwell、Sample 和 Racine 于 2017 年发表脑机接口伦理范围综述，把同意、隐私、身份、责任、人格边界和神经权利等议题纳入系统审查框架。", "summary": "该综述为脑机接口从设备研发走向人体试验提供了伦理与治理基础。", "sources": [ "SRC-110" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "伦理框架不直接解决具体产品的安全性或身份连续性证明。", "cross_links": [ "HIT-TEC-011", "HIT-THT-021" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 PMC 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:25:45.092015Z", "updated_at": "2026-08-06T10:25:45.092015Z" }, { "event_id": "HIT-SCI-021", "title": "首个临床异种肾移植研究方案 EXPAND 公开", "date_start": "2025-12-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "practice", "claim": "Nashan 于 2025 年 12 月公开首个临床异种肾移植研究 EXPAND 的方案设计，评价基因编辑猪肾移植的安全、功能和人畜共患风险。", "summary": "EXPAND 把异种肾移植从单例同情使用推进到正式临床研究设计阶段，但仍以安全性和功能评价为目标。", "sources": [ "SRC-111" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "研究方案公开不等于已完成临床试验或人体疗效证明。", "cross_links": [ "HIT-TEC-009", "HIT-TEC-010" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PMC 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:25:45.092015Z", "updated_at": "2026-08-06T10:25:45.092015Z" }, { "event_id": "HIT-TEC-019", "title": "大鼠肾脏玻璃化保存并成功移植", "date_start": "2023-06-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Laboratory", "path_family": "suspension", "event_type": "technology", "claim": "Han 等人 2023 年在 Nature Communications 报告，通过玻璃化和纳米复温保存大鼠肾脏长达 100 天，移植后恢复生命支持性肾功能。", "summary": "该研究把器官保存从短时冷藏推进到可长期储存的玻璃化方向，但仍是大鼠模型，离人体器官库很远。", "sources": [ "SRC-112" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "动物模型结果不能直接外推到人体器官；长期保存后的分子和功能完整性仍需验证。", "cross_links": [ "HIT-TEC-003", "HIT-TEC-016" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Nature Communications 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:28:19.319324Z", "updated_at": "2026-08-06T10:28:19.319324Z" }, { "event_id": "HIT-TEC-020", "title": "常温机器灌注肺保存长期结果发表", "date_start": "2025-07-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "Loor 等人 2025 年在 EClinicalMedicine 报告国际 EXPAND 试验中 Organ Care System 常温机器灌注肺保存的长期结局。", "summary": "机器灌注把器官保存从静态冷藏扩展为动态维生系统，为器官可及性和移植连续性提供工程路径。", "sources": [ "SRC-113" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该结果针对捐献肺移植场景，不直接支持人体整体或大脑保存。", "cross_links": [ "HIT-TEC-017", "HIT-TEC-019" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 EClinicalMedicine/PMC 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:28:19.319324Z", "updated_at": "2026-08-06T10:28:19.319324Z" }, { "event_id": "HIT-TEC-021", "title": "器官玻璃化保存向升尺度推进", "date_start": "2025-09-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Laboratory", "path_family": "suspension", "event_type": "technology", "claim": "Gangwar 等人 2025 年在 Nature Communications 报告在升尺度保护剂体积下进行物理玻璃化和纳米复温，向器官保存库推进。", "summary": "升尺度玻璃化解决器官银行规模化中的关键工程问题，但仍属于临床前研究。", "sources": [ "SRC-114" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "升尺度体积仍在实验阶段，未证明可保存完整人体器官并恢复功能。", "cross_links": [ "HIT-TEC-019", "HIT-SCI-113" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Nature Communications 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:28:19.319324Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-027", "title": "类器官智能伦理议题系统化", "date_start": "2026-03-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "Boyd 等人 2026 年在 Scientific Reports 研究具身脑类器官的伦理担忧，讨论意识、身份、人格边界和神经伦理问题。", "summary": "类器官智能从能力路线扩展出独立伦理审查层，防止把生物计算等同于人类主体。", "sources": [ "SRC-115" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "伦理研究不证明类器官具有意识，也不否定其计算研究价值。", "cross_links": [ "HIT-THT-021", "HIT-TEC-008" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Scientific Reports/PMC 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:28:19.319324Z", "updated_at": "2026-08-06T10:28:19.319324Z" }, { "event_id": "HIT-THT-028", "title": "AI 风险分类数据库发表", "date_start": "2026-03-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "thought", "claim": "Slattery 等人 2026 年在 Patterns 发布 AI Risk Repository，对 AI 风险进行元综述、数据库和分类法整理，支持技术治理和风险审查。", "summary": "AI 风险治理从单篇讨论转向可检索、可比较、可审计的分类基础设施。", "sources": [ "SRC-116" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "分类数据库是治理工具，不直接证明特定风险的概率或影响。", "cross_links": [ "HIT-THT-026", "HIT-TEC-013" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Patterns/PMC 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:28:19.319324Z", "updated_at": "2026-08-06T10:28:19.319324Z" }, { "event_id": "HIT-INS-011", "title": "NewLimit 完成 4.35 亿美元 C 轮融资", "date_start": "2026-06-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "reconstruction", "event_type": "institution", "claim": "NewLimit 于 2026 年 6 月 2 日宣布完成 4.35 亿美元 C 轮融资，由 Founders Fund 领投，计划次年将首个肝脏表观遗传重编程药物推进人体试验。", "summary": "该融资显示表观遗传重编程从科研转向产业化和人体试验基础设施阶段。", "sources": [ "SRC-117" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "公司声明与融资额需独立核验；融资不证明药物疗效。", "cross_links": [ "HIT-SCI-007", "HIT-TEC-013" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 Internet Archive 快照核验官方公告。", "created_at": "2026-08-06T10:28:19.319324Z", "updated_at": "2026-08-06T10:28:19.319324Z" }, { "event_id": "HIT-TEC-022", "title": "3D 生物打印可灌注心脏补片与迷你心脏", "date_start": "2019-06-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Israel", "region": "Laboratory", "path_family": "reconstruction", "event_type": "technology", "claim": "Noor 等人 2019 年在 Advanced Science 报告，利用患者细胞和 3D 打印技术制造可灌注心脏补片与迷你心脏，推进器官工程从支架结构走向功能组织。", "summary": "该研究显示生物打印可在小尺度生成血管化心脏组织，但离可移植全尺寸器官仍有巨大距离。", "sources": [ "SRC-118" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "实验室组织不等于可移植器官，长期功能、免疫和规模化问题未解决。", "cross_links": [ "HIT-TEC-009", "HIT-TEC-019" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PMC 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:31:41.228037Z", "updated_at": "2026-08-06T10:31:41.228037Z" }, { "event_id": "HIT-SCI-022", "title": "OSK 基因疗法延长老龄小鼠剩余寿命", "date_start": "2024-02-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Laboratory", "path_family": "reconstruction", "event_type": "practice", "claim": "Macip 等人 2024 年在 Cellular Reprogramming 报告，通过 AAV 递送诱导型 OSK 部分重编程，延长高龄小鼠中位剩余寿命并改善年龄相关标志物。", "summary": "该结果把部分重编程从小鼠全身性实验推进到基因疗法递送，但仍属临床前动物研究。", "sources": [ "SRC-119" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "剩余寿命延长不等于总寿命翻倍，人体剂量、递送和安全性仍需验证。", "cross_links": [ "HIT-SCI-007", "HIT-SCI-011", "HIT-TEC-013" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PMC 页面和 PubMed 元数据核验。；日期补齐：Crossref 2024-02-15 (published-online, day, v3)", "created_at": "2026-08-06T10:31:41.228037Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-INS-012", "title": "Longevity Fund 成立", "date_start": "2011", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "Laura Deming 于 2011 年成立 The Longevity Fund，成为较早以长寿与衰老科学为主题的风险投资基金。", "summary": "该基金把长寿研究从科研和公益叙事带入早期风险投资体系，推动产业基础设施形成。", "sources": [ "SRC-120" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "基金成立年份来自官网自述；投资实际影响需按项目和组合逐年核验。", "cross_links": [ "HIT-INS-009", "HIT-INS-011" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做官方页面可达性核验。", "created_at": "2026-08-06T10:31:41.228037Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-POL-004", "title": "WHO 发布全球年龄歧视报告", "date_start": "2021-03-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "WHO 于 2021 年 3 月 18 日发布《全球年龄歧视报告》，把年龄歧视列为影响健康寿命和健康老龄化的公共政策议题。", "summary": "该报告把“延长寿命”进一步纳入社会公平、照护和年龄正义框架。", "sources": [ "SRC-121" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "报告提供政策证据与行动建议，不直接证明具体延寿干预有效。", "cross_links": [ "HIT-POL-001", "HIT-POL-002" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 WHO 官方页面元数据核验。", "created_at": "2026-08-06T10:31:41.228037Z", "updated_at": "2026-08-06T10:31:41.228037Z" }, { "event_id": "HIT-POL-005", "title": "NIST 发布 AI 风险管理框架 1.0", "date_start": "2023-01-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cross_path", "event_type": "policy", "claim": "NIST 于 2023 年 1 月 26 日发布 AI Risk Management Framework 1.0，为 AI 设计、开发、使用和评估提供自愿性风险管理框架。", "summary": "该框架为 AI 安全与长寿技术治理提供标准接口，但不能替代具体产品和系统的安全验证。", "sources": [ "SRC-122" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "框架是自愿性指南，不构成法律强制或具体模型安全证明。", "cross_links": [ "HIT-THT-028", "HIT-POL-003" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 NIST 官方页面核验。", "created_at": "2026-08-06T10:31:41.228037Z", "updated_at": "2026-08-06T10:31:41.228037Z" }, { "event_id": "HIT-INS-013", "title": "Turn Bio 建立 mRNA 表观遗传重编程平台", "date_start": "2022", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "San Francisco / Mountain View", "path_family": "reconstruction", "event_type": "institution", "claim": "Turn Biotechnologies 以 Epigenetic Reprogramming of Age (ERA) 平台为核心，使用 mRNA 鸡尾酒恢复细胞年轻功能并维持细胞身份。", "summary": "该平台代表从病毒基因递送转向短暂 mRNA 重编程的产业路线，但仍是临床前平台。", "sources": [ "SRC-123" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "官网自述成立和平台状态；平台不代表已有人体疗效。", "cross_links": [ "HIT-TEC-013", "HIT-INS-011" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 Internet Archive 快照核验官网。", "created_at": "2026-08-06T10:31:41.228037Z", "updated_at": "2026-08-06T10:31:41.228037Z" }, { "event_id": "HIT-TEC-023", "title": "FDA 批准首个自动胰岛素给药闭环系统", "date_start": "2016-09-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America", "path_family": "reconstruction", "event_type": "technology", "claim": "FDA 于 2016 年 9 月 28 日批准 Medtronic MiniMed 670G，首个自动监测血糖并调整基础胰岛素的混合闭环设备，被称为“人工胰腺”。", "summary": "该设备证明身体功能可由传感器、算法和执行器组成的闭环系统部分替代，是身体功效替代研究的重要历史前置案例。", "sources": [ "SRC-124" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该批准针对特定内分泌功能，不等于整体器官或脑-身接口替代。", "cross_links": [ "HIT-TEC-017", "HIT-TEC-022" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 Internet Archive 快照核验 FDA 公告。", "created_at": "2026-08-06T10:35:38.745574Z", "updated_at": "2026-08-06T10:35:38.745574Z" }, { "event_id": "HIT-SCI-023", "title": "衰老标志物验证标准发表", "date_start": "2024-02-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "Moqri 等人 2024 年在 Nature Medicine 发表衰老标志物验证框架，把表观遗传时钟、蛋白组和分子指标从研究工具推向可审查的临床/队列验证标准。", "summary": "该事件为生物年龄指标用于干预反馈提供更严格的验证要求，但标志物改善不直接等于寿命延长。", "sources": [ "SRC-125" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "验证框架是方法标准，不是任何具体标志物疗效证明。", "cross_links": [ "HIT-SCI-009", "HIT-SCI-019" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PMC 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:35:38.745574Z", "updated_at": "2026-08-06T10:35:38.745574Z" }, { "event_id": "HIT-TEC-024", "title": "生成式 AI 发现药物进入随机 IIa 期试验", "date_start": "2025-06-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "Xu 等人 2025 年在 Nature Medicine 报告，生成式 AI 发现的 TNIK 抑制剂进入特发性肺纤维化随机 IIa 期试验。", "summary": "该试验把 AI 药物发现从靶点预测推进到人体随机试验阶段，但仍属于早期疗效验证。", "sources": [ "SRC-126" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "IIa 期结果不代表获批药物，也未证明可延寿。", "cross_links": [ "HIT-TEC-013", "HIT-SCI-023", "HIT-SCI-112", "HIT-PRA-017" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PMC 页面和 PubMed 元数据核验。；日期补齐：Crossref 2025-06-03 (published-online, day, v3)", "created_at": "2026-08-06T10:35:38.745574Z", "updated_at": "2026-08-08T06:28:04Z" }, { "event_id": "HIT-THT-029", "title": "长寿生物技术整合 AI、标志物与老年科学", "date_start": "2024-10-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "thought", "claim": "Lyu 等人 2024 年在 Aging 发表综述，提出把 AI、生物标志物、老年科学和临床转化整合为长寿生物技术路线。", "summary": "该框架显示长寿研究正从单点干预转向 AI 驱动的系统化工具链。", "sources": [ "SRC-127" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "综述提出研究纲领，不代表工具链已经达到长寿逃逸速度。", "cross_links": [ "HIT-SCI-023", "HIT-TEC-024" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PMC 页面和 PubMed 元数据核验。", "created_at": "2026-08-06T10:35:38.745574Z", "updated_at": "2026-08-06T10:35:38.745574Z" }, { "event_id": "HIT-POL-006", "title": "美国发布 AI 安全与可信发展行政令", "date_start": "2023-10-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cross_path", "event_type": "policy", "claim": "美国总统于 2023 年 10 月 30 日签署行政令，要求对 AI 风险、生物安全、网络安全和国家安全相关能力进行联邦协调治理。", "summary": "该行政令把 AI 安全从行业自律推进为国家治理议程，也影响 AI 驱动的生物与长寿技术研发环境。", "sources": [ "SRC-128" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "行政令是政策框架，后续执行、撤销和替代情况需持续核验。", "cross_links": [ "HIT-POL-005", "HIT-THT-028" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做白宫官方存档页核验。", "created_at": "2026-08-06T10:35:38.745574Z", "updated_at": "2026-08-06T10:35:38.745574Z" }, { "event_id": "HIT-THT-030", "title": "洛克《人类理解论》讨论记忆与人格同一性", "date_start": "1689", "date_type": "approx", "period_id": "period-early-modern-europe", "civilization": "England", "region": "Europe", "path_family": "philosophical", "event_type": "thought", "claim": "洛克在《人类理解论》中把个人同一性主要建立在意识与记忆连续性上，使“我是谁”从灵魂实体转向主体经验连续性。", "summary": "该文本为后来意识上传、记忆外化和数字身份讨论提供了哲学起点。", "sources": [ "SRC-129" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "洛克原文讨论哲学同一性，不是生物学或技术意义上的永生方案。", "cross_links": [ "HIT-THT-031", "HIT-LIT-004" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Project Gutenberg 公版书可达性核验。", "created_at": "2026-08-06T10:39:17.349356Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-031", "title": "休谟《人性论》提出自我是知觉束", "date_start": "1739", "date_type": "approx", "period_id": "period-enlightenment", "civilization": "Scotland", "region": "Europe", "path_family": "philosophical", "event_type": "thought", "claim": "休谟在《人性论》中认为自我不是固定实体，而是不断变化的知觉束，削弱了“灵魂永生或人格延续”的自然性预设。", "summary": "该文本为质疑数字复制和意识上传中的同一性提供了重要哲学资源。", "sources": [ "SRC-130" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "哲学分析不等于心理学或神经科学实证结论。", "cross_links": [ "HIT-THT-030", "HIT-THT-032" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Project Gutenberg 公版书可达性核验。", "created_at": "2026-08-06T10:39:17.349356Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-032", "title": "康德《纯粹理性批判》重构时间与自我条件", "date_start": "1781", "date_type": "approx", "period_id": "period-enlightenment", "civilization": "Germany", "region": "Europe", "path_family": "philosophical", "event_type": "thought", "claim": "康德在《纯粹理性批判》中把时间、经验和统觉统一性作为认识可能条件，为“主体如何持续成为同一主体”提供先验哲学框架。", "summary": "该框架成为后续先验论证、主体持续性和自我同一性讨论的重要基础。", "sources": [ "SRC-131" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "康德讨论的是认识条件，不是具体技术实现或经验心理学。", "cross_links": [ "HIT-THT-030", "HIT-THT-031" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Project Gutenberg 公版书可达性核验。", "created_at": "2026-08-06T10:39:17.349356Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-LIT-007", "title": "托尔斯泰《伊凡·伊里奇之死》把死亡意识文学化", "date_start": "1886", "date_type": "approx", "period_id": "period-19th-century", "civilization": "Russia", "region": "Europe", "path_family": "philosophical", "event_type": "literature", "claim": "托尔斯泰在《伊凡·伊里奇之死》中描写普通人在疾病和死亡中的孤独、自欺与最终觉醒，把死亡意识从宗教教义转化为现代心理小说主题。", "summary": "该作品强化了“延长寿命不等于获得意义”的反省传统。", "sources": [ "SRC-132" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "文学作品提供文化和心理观察，不构成医学或哲学定论。", "cross_links": [ "HIT-LIT-004", "HIT-LIT-005" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 数字档案可达性核验。", "created_at": "2026-08-06T10:39:17.349356Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-LIT-008", "title": "博尔赫斯《永生》重写永生与记忆困境", "date_start": "1949", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Argentina", "region": "Latin America", "path_family": "philosophical", "event_type": "literature", "claim": "博尔赫斯在《阿莱夫》中收录《永生》，借永生者失去记忆、差异与意义，质疑无限生命是否必然等于更好生命。", "summary": "该作品把永生从愿望反转为认知和存在论困境，成为 20 世纪永生文学的核心文本。", "sources": [ "SRC-133" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "该故事最初发表和结集时间存在版本差异，本事件以《阿莱夫》结集年份记录。", "cross_links": [ "HIT-LIT-003", "HIT-LIT-004" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 英文合集可达性核验。", "created_at": "2026-08-06T10:39:17.349356Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-033", "title": "卢克莱修《物性论》把生命还原为原子运动", "date_start": "-50~", "date_type": "approx", "period_id": "period-roman-republic", "civilization": "Roman Republic", "region": "Italy / Mediterranean", "path_family": "philosophical", "event_type": "thought", "claim": "卢克莱修在《物性论》中以原子论解释生命、感觉和死亡，主张灵魂随身体分解而消散，为自然主义生死观提供系统诗学文本。", "summary": "该文本成为反对灵魂不朽与死后延续的重要古典源头。", "sources": [ "SRC-134" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "诗歌完成年代约公元前 1 世纪中叶，具体成书时间存在争议。", "cross_links": [ "HIT-THT-003", "HIT-THT-031" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Project Gutenberg 公版书可达性核验。", "created_at": "2026-08-06T18:50:00Z", "updated_at": "2026-08-06T18:50:00Z" }, { "event_id": "HIT-THT-034", "title": "《庄子》提出养生与生死自然转化", "date_start": "-300~", "date_type": "approx", "period_id": "period-warring-states-han", "civilization": "China", "region": "Warring States China", "path_family": "philosophical", "event_type": "thought", "claim": "《庄子》以“缘督以为经”“安时而处顺”等表述，把养生从追求肉体不朽转向顺应自然、保养生命与超越死亡焦虑。", "summary": "它与《道德经》共同构成道家生死观和后世养生实践的思想基础。", "sources": [ "SRC-135" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "《庄子》各篇形成年代跨度大，养生思想主要归入战国中期文本层。", "cross_links": [ "HIT-THT-017", "HIT-THT-004" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。本轮已做 Chinese Text Project 原文可达性核验。", "created_at": "2026-08-06T18:50:00Z", "updated_at": "2026-08-06T18:50:00Z" }, { "event_id": "HIT-THT-035", "title": "塞涅卡《论生命短暂》提出生命长度取决于使用而非天数", "date_start": "49~", "date_type": "approx", "period_id": "period-roman-empire", "civilization": "Roman Empire", "region": "Rome / Mediterranean", "path_family": "philosophical", "event_type": "thought", "claim": "塞涅卡在《论生命短暂》中主张生命并非天然短促，而是被娱乐、琐务和对未来的期待浪费，把“活得久”重新定义为“善用当下时间”。", "summary": "该文本为有效时间、主观时间和生命意义讨论提供古典源头。", "sources": [ "SRC-136" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "对话写作年代约公元 49 年，为现代学者常用推定。", "cross_links": [ "HIT-THT-032", "HIT-LIT-007" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 译文可达性核验。", "created_at": "2026-08-06T18:50:00Z", "updated_at": "2026-08-06T18:50:00Z" }, { "event_id": "HIT-SCI-024", "title": "伊本·西那《医典》完成中古医学体系", "date_start": "1025~", "date_type": "approx", "period_id": "period-medieval-islamic-world", "civilization": "Persia / Islamic world", "region": "Central Asia / Middle East", "path_family": "maintenance", "event_type": "practice", "claim": "伊本·西那在《医典》中系统整理体液理论、疾病分类、药物、养生与治疗，使医学作为可教授知识体系在伊斯兰世界和拉丁欧洲长期传承。", "summary": "《医典》把古代医学和自然哲学组织为教学性著作，影响长寿与健康养护知识数个世纪。", "sources": [ "SRC-137" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "具体完成时间有约 1020-1025 年的推定，各卷流传和翻译过程复杂。", "cross_links": [ "HIT-PRA-003", "HIT-PRA-005" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 英译本可达性核验。", "created_at": "2026-08-06T18:50:00Z", "updated_at": "2026-08-06T18:50:00Z" }, { "event_id": "HIT-INS-014", "title": "Academy for Health and Lifespan Research 更名 Academy of Geroscience", "date_start": "2026-05-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "New York / Global", "path_family": "maintenance", "event_type": "institution", "claim": "AHLR 于 2026 年 5 月 7 日宣布更名为 Academy of Geroscience，将使命聚焦于衰老生物学科学基础的定义与提升。", "summary": "该更名反映老年科学在健康寿命研究基础设施中从“延长寿命”转向“科学严谨和学科命名”的机构治理趋势。", "sources": [ "SRC-138" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "机构更名不改变其成员科学立场，也不等同于研究资助或临床成果。", "cross_links": [ "HIT-INS-005", "HIT-INS-009" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PR Newswire 官方新闻稿可达性核验。", "created_at": "2026-08-06T18:50:00Z", "updated_at": "2026-08-06T18:50:00Z" }, { "event_id": "HIT-THT-036", "title": "尼采提出永恒轮回与超人生命观", "date_start": "1882", "date_type": "approx", "period_id": "period-19th-century", "civilization": "Germany", "region": "Europe", "path_family": "philosophical", "event_type": "thought", "claim": "尼采在《快乐的科学》中提出永恒轮回思想，要求人肯定生命的重复与强度，而非依赖来世或永生补偿。", "summary": "该思想构成 19 世纪晚期对永生许诺的重要哲学反驳之一。", "sources": [ "SRC-139" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "永恒轮回在尼采文本中的理论地位和解释存在争议。", "cross_links": [ "HIT-LIT-008", "HIT-THT-031" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 英译本可达性核验。", "created_at": "2026-08-06T18:50:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-025", "title": "埃伯斯纸草形成现存较早的大型医学文献", "date_start": "-1550~", "date_type": "approx", "period_id": "period-ancient-egypt-new-kingdom", "civilization": "Ancient Egypt", "region": "Nile Valley", "path_family": "maintenance", "event_type": "practice", "claim": "埃伯斯纸草汇集疾病描述、药方、咒语和身体养护知识，显示古埃及已把健康、疾病与生命延续写入可抄传的医学文献。", "summary": "该纸草是研究早期医学如何把寿命与身体维护问题文本化的重要史料。", "sources": [ "SRC-140" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "纸草抄写年代有约公元前 1550 年的推定，其中医学内容可能来自更早传统。", "cross_links": [ "HIT-MTH-001", "HIT-PRA-001" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 数字档案可达性核验。", "created_at": "2026-08-06T19:10:00Z", "updated_at": "2026-08-06T19:10:00Z" }, { "event_id": "HIT-THT-037", "title": "奥古斯丁《上帝之城》系统化复活与永恒生命", "date_start": "413~", "date_end": "426~", "date_type": "range", "period_id": "period-late-antiquity", "civilization": "Roman Empire / North Africa", "region": "Mediterranean", "path_family": "philosophical", "event_type": "religious", "claim": "奥古斯丁在《上帝之城》中把身体复活、永恒生命和上帝之城秩序整合为系统神学，使永生成为西方文明中长期争论的教义对象。", "summary": "该文本把早期基督教复活信仰从末世预言扩展为政治、历史与身体哲学的宏大叙事。", "sources": [ "SRC-141" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "《上帝之城》写作跨越约 413-426 年，各卷完成顺序存在学术讨论。", "cross_links": [ "HIT-MTH-003", "HIT-MTH-004" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Project Gutenberg 公版书可达性核验。", "created_at": "2026-08-06T19:10:00Z", "updated_at": "2026-08-06T19:10:00Z" }, { "event_id": "HIT-PRA-011", "title": "罗吉尔·培根《老年治疗与青春保存》英译本出版", "date_start": "1683", "date_type": "approx", "period_id": "period-early-modern-europe", "civilization": "England", "region": "England / Europe", "path_family": "maintenance", "event_type": "practice", "claim": "1683 年出版的《老年治疗与青春保存》把罗吉尔·培根关于延长生命、饮食养生和身体保健的中世纪主张带入近代英语医学市场。", "summary": "该译本显示长寿知识在中世纪晚期至近代早期持续被消费和再版。", "sources": [ "SRC-142" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "原书作者归属和写作年代有争议；本事件只记录 1683 年英译本出版事实。", "cross_links": [ "HIT-THT-006", "HIT-PRA-006" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 早期英文书影印可达性核验。", "created_at": "2026-08-06T19:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-038", "title": "乌纳穆诺《生命的悲剧意识》提出永生意愿与理性冲突", "date_start": "1913", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Spain", "region": "Europe", "path_family": "philosophical", "event_type": "thought", "claim": "乌纳穆诺在《生命的悲剧意识》中把个体对不死的渴望视为生命核心，认为理性无法证明永生而意志不能放弃它，构成现代存在论的生命哲学命题。", "summary": "该文本把“永生”从神学或医学问题重新定义为人的存在结构问题。", "sources": [ "SRC-143" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "哲学解释不等于心理学或神经科学结论。", "cross_links": [ "HIT-LIT-007", "HIT-THT-031" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 英译本可达性核验。", "created_at": "2026-08-06T19:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-039", "title": "哈林顿《不朽主义者》把永生工程化", "date_start": "1969", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "cross_path", "event_type": "thought", "claim": "哈林顿在《不朽主义者》中主张人类应把“神圣性”重新定义为可工程化的永生目标，推动永生从宗教想象转向科学和技术的世俗议程。", "summary": "该书成为 20 世纪后半叶 immortalist 运动和生命延长技术文化的重要文本。", "sources": [ "SRC-144" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该书的未来主义主张是文化和思想表达，不等同于技术可行性证明。", "cross_links": [ "HIT-THT-022", "HIT-PRA-007" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 数字档案可达性核验。", "created_at": "2026-08-06T19:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-DEM-004", "title": "人类死亡率数据库建立", "date_start": "2002", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "institution", "claim": "人类死亡率数据库由加州大学伯克利分校与德国马普人口研究所于 2002 年建立，提供跨国长期年龄别死亡率和寿命表，成为长寿研究的人口统计基础设施。", "summary": "HMD 让死亡率下降、寿命延长和长寿逃逸速度的实证讨论拥有可比较、可复核的数据基础。", "sources": [ "SRC-145" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "HMD 覆盖国家、时期和方法会更新，数据库建立年份以官方项目说明为准。", "cross_links": [ "HIT-DEM-001", "HIT-DEM-002" ], "chapter": "人口统计、死亡率与健康寿命", "notes": "draft，等待来源语境复核。本轮已做 HMD 官方站点可达性核验。", "created_at": "2026-08-06T19:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-025", "title": "AlphaFold 2 实现高精度蛋白质结构预测", "date_start": "2021-07-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Global", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "Jumper 等人在 2021 年 7 月 15 日于 Nature 报告 AlphaFold 2，以接近实验精度预测蛋白质三维结构，把生物学从人工解析推向可扩展的计算模拟。", "summary": "AlphaFold 2 是 AI 加速生命科学和疾病研究的代表性节点，也改变了蛋白质相关衰老与修复研究的工具基础。", "sources": [ "SRC-146" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "结构预测精度不等于完整理解蛋白功能、相互作用或体内药效。", "cross_links": [ "HIT-TEC-024", "HIT-TEC-013" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T19:30:00Z", "updated_at": "2026-08-06T19:30:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-SCI-026", "title": "AlphaMissense 预测人类错义突变效应", "date_start": "2023-09-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Global", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "Cheng 等人在 2023 年 9 月 19 日于 Science 报告 AlphaMissense，为 7100 万种可能的人类错义突变提供效应预测，把基因变异解读带入大规模计算评估。", "summary": "该工具扩展了基因组医学的筛查能力，但预测结果仍需临床和实验验证。", "sources": [ "SRC-147" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "预测不等同于临床致病性判定，误报和漏报需要持续校准。", "cross_links": [ "HIT-TEC-025", "HIT-SCI-023" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据可达性核验。", "created_at": "2026-08-06T19:30:00Z", "updated_at": "2026-08-06T19:30:00Z" }, { "event_id": "HIT-INS-015", "title": "2020 年诺贝尔化学奖授予 CRISPR 基因编辑", "date_start": "2020-10-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / France / Global", "region": "Global", "path_family": "reconstruction", "event_type": "institution", "claim": "诺贝尔奖委员会于 2020 年 10 月 7 日把化学奖授予 Doudna 和 Charpentier，表彰其开发 CRISPR-Cas9 基因组编辑方法，确立基因编辑作为生命科学基础工具的官方地位。", "summary": "CRISPR 诺奖把可编程基因组改造正式纳入主流科学制度，推动基因修复、疾病治疗和抗衰路线的基础设施化。", "sources": [ "SRC-148" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "奖项承认方法学贡献，不等于基因编辑疗法已普遍安全或可治疗衰老。", "cross_links": [ "HIT-TEC-005", "HIT-SCI-007" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做诺贝尔奖官方页面可达性核验。", "created_at": "2026-08-06T19:30:00Z", "updated_at": "2026-08-06T19:30:00Z" }, { "event_id": "HIT-THT-040", "title": "《追求长寿红利》把延长健康寿命定义为科学议程", "date_start": "2006", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "Olshansky 等人在 2006 年发表《追求长寿红利》，主张把健康寿命延长作为公共卫生、生物医学和社会政策共同追求的目标，而不只关注延长生命本身。", "summary": "该文为老年科学从“延寿”转向“健康寿命与社会收益”提供了重要表述。", "sources": [ "SRC-149" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "长寿红利的收益估计依赖未来健康寿命改善，具有政策推断性质。", "cross_links": [ "HIT-THT-015", "HIT-POL-002" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据可达性核验。", "created_at": "2026-08-06T19:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-027", "title": "克隆羊多莉出生，证明体细胞可重编程为新个体", "date_start": "1996-07-05", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United Kingdom", "region": "Scotland / Europe", "path_family": "reconstruction", "event_type": "technology", "claim": "罗瑟林研究所团队于 1996 年 7 月 5 日迎来克隆羊多莉出生，证明成熟体细胞核可被重编程为新个体，为细胞重编程和再生医学提供关键里程碑。", "summary": "多莉把“成熟细胞能否重新启动发育程序”从理论变为可观察事实，影响后续 iPS 和克隆研究。", "sources": [ "SRC-2599", "SRC-2600" ], "evidence_grade": "S", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "克隆效率低且存在表观遗传异常，多莉不代表个体复制或永生的可靠路径。", "cross_links": [ "HIT-SCI-007", "HIT-THT-014" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "来源纠偏：改用 Wilmut et al. 1997 原始论文并补 Wikipedia 出生日期背景。本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T19:50:00Z", "updated_at": "2026-08-06T19:50:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-SCI-028", "title": "短暂非整合 mRNA 重编程改善人类衰老细胞", "date_start": "2020-04-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Global", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "Sarkar 等人在 2020 年 4 月 27 日于 Nature Communications 报告，短暂非整合 mRNA 重编程可重置人类衰老细胞表观遗传时钟并降低炎症特征，同时保留大体细胞身份。", "summary": "该研究支持“短暂重编程可能分离年轻化与去分化”的路线，为更安全的细胞年轻化提供概念证据。", "sources": [ "SRC-151" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "体外细胞证据不等于人体治疗有效，长期安全性和体内效果仍待验证。", "cross_links": [ "HIT-SCI-011", "HIT-SCI-029" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Nature Communications 论文页可达性核验。", "created_at": "2026-08-06T19:50:00Z", "updated_at": "2026-08-06T19:50:00Z" }, { "event_id": "HIT-SCI-029", "title": "MPTR 使人类成纤维细胞分子年龄显著年轻化", "date_start": "2022-04-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Global", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "Gill 等人在 2022 年 4 月 8 日于 eLife 报告 MPTR 方法，在人类皮肤成纤维细胞成熟阶段短暂重编程，使转录组和表观遗传年龄指标显著年轻化并保留细胞身份。", "summary": "MPTR 是“年龄重置与身份保留可部分解耦”路线的重要人类体外证据，但不等同于人体返老还童疗法。", "sources": [ "SRC-152" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "分子年龄改善不直接等同于功能恢复、疾病风险下降或寿命延长。", "cross_links": [ "HIT-SCI-028", "HIT-SCI-011" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 eLife 论文页与 PMC 全文可达性核验。", "created_at": "2026-08-06T19:50:00Z", "updated_at": "2026-08-06T19:50:00Z" }, { "event_id": "HIT-SCI-030", "title": "TRIIM 人体试验报告表观衰老逆转", "date_start": "2019-09-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "California / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "Fahy 等人在 2019 年 9 月 8 日于 Aging Cell 报告 TRIIM 试验，9 名健康男性接受生长激素、脱氢表雄酮和二甲双胍组合干预后，胸腺与免疫细胞表观年龄出现逆转向信号。", "summary": "TRIIM 是较早把多组临床可用药物用于表观年龄和胸腺重建探索的人体研究，但样本小且机制不完整。", "sources": [ "SRC-153" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "小样本、无对照设计和随访有限，不能作为延寿治疗有效性的证明。", "cross_links": [ "HIT-SCI-019", "HIT-FAI-003" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-06T20:10:00Z", "updated_at": "2026-08-06T20:10:00Z" }, { "event_id": "HIT-INS-016", "title": "FDA 批准首个 CRISPR 基因疗法 Casgevy", "date_start": "2023-12-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "reconstruction", "event_type": "institution", "claim": "FDA 于 2023 年 12 月 8 日批准 Casgevy，成为首个获批的 CRISPR-Cas9 基因编辑疗法，用于治疗镰状细胞病相关复发血管闭塞危象。", "summary": "该批准标志可编程基因组编辑从实验工具进入正式监管治疗路径。", "sources": [ "SRC-154" ], "evidence_grade": "S", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "批准针对特定遗传病，不代表基因编辑疗法普遍适用或已解决衰老问题。", "cross_links": [ "HIT-INS-015", "HIT-TEC-005" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T20:10:00Z", "updated_at": "2026-08-06T20:10:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-TEC-026", "title": "首个体内 CRISPR 基因编辑临床数据发表", "date_start": "2021-06-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "Gillmore 等人在 2021 年 6 月 26 日于 NEJM 报告 NTLA-2001 的 1 期数据，显示 CRISPR-Cas9 可在人体内编辑肝细胞靶基因并降低血清转甲状腺素蛋白水平。", "summary": "该数据是体内 CRISPR 治疗从概念进入人体可测量的关键早期证据。", "sources": [ "SRC-155" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "1 期样本量小、随访短，长期安全性和疗效仍需更大试验验证。", "cross_links": [ "HIT-INS-016", "HIT-TEC-005" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T20:10:00Z", "updated_at": "2026-08-06T20:10:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-FAI-007", "title": "FDA 发布干细胞疗法风险警告", "date_start": "2019-03-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "cross_path", "event_type": "failure", "claim": "FDA 于 2019 年 3 月 20 日发布消费者更新，警告未经批准干细胞疗法可能带来感染、肿瘤、异位组织和严重不良事件，并把监管要求与虚假宣称区分开。", "summary": "该警告强化了“再生医学必须先证明安全和有效性”的监管边界。", "sources": [ "SRC-156" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "警告针对未经批准产品，不代表所有干细胞研究或未来疗法均无效。", "cross_links": [ "HIT-FAI-004", "HIT-SCI-007" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 FDA 消费者更新 Internet Archive 存档核验。", "created_at": "2026-08-06T20:10:00Z", "updated_at": "2026-08-06T20:10:00Z" }, { "event_id": "HIT-INS-017", "title": "Buck Institute 建立首个专注衰老生物学独立研究所", "date_start": "1999-09-30", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "California / North America", "path_family": "maintenance", "event_type": "institution", "claim": "Buck Institute 于 1999 年 9 月 30 日开放，成为世界首个以衰老生物学为唯一研究焦点的独立生物医学研究所。", "summary": "Buck 的成立把衰老研究从分散课题整合为专门机构，为后续 geroscience 基础设施提供组织原型。", "sources": [ "SRC-157", "SRC-158" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "官方历史页与 Wikipedia 对开放日期一致，但机构影响是长期历史判断。", "cross_links": [ "HIT-INS-001", "HIT-THT-015" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做机构官方历史页和 Wikipedia 交叉核验。", "created_at": "2026-08-06T20:30:00Z", "updated_at": "2026-08-06T20:30:00Z" }, { "event_id": "HIT-INS-018", "title": "SENS Research Foundation 成立", "date_start": "2009", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "California / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "SENS Research Foundation 于 2009 年成立，围绕 Aubrey de Grey 提出的七类衰老损伤修复议程组织研究、教育和产业化推动。", "summary": "该机构把“修复衰老损伤”从个人理论转为持续运作的研究组织。", "sources": [ "SRC-159" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "机构后续与 LEAF 合并为 Lifespan Research Institute，本事件记录 2009 年成立节点。", "cross_links": [ "HIT-THT-023", "HIT-INS-007" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 与 SENS 历史页面交叉核验。", "created_at": "2026-08-06T20:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-019", "title": "Calico 成立并把衰老生物学带入大型科技公司议程", "date_start": "2013-09-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "California / Global", "path_family": "maintenance", "event_type": "institution", "claim": "Calico 于 2013 年 9 月 18 日成立，由 Google/Alphabet 支持，以延长健康寿命和对抗衰老疾病为目标，标志大型科技资本进入衰老生物学。", "summary": "Calico 是科技产业把衰老研究视为长期基础设施的重要组织节点。", "sources": [ "SRC-160" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "公司内部研究进展披露有限，成立事实清楚但成果评价需等待公开证据。", "cross_links": [ "HIT-INS-005", "HIT-INS-011" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T20:30:00Z", "updated_at": "2026-08-06T20:30:00Z" }, { "event_id": "HIT-INS-020", "title": "UK Biobank 主研究启动", "date_start": "2007-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United Kingdom", "region": "United Kingdom", "path_family": "maintenance", "event_type": "institution", "claim": "UK Biobank 于 2007 年 4 月启动主研究，招募 40-69 岁英国志愿者并长期随访健康、遗传和环境数据，成为健康寿命研究的重要纵向队列。", "summary": "UK Biobank 为衰老、疾病和寿命研究提供大规模可复用数据基础设施。", "sources": [ "SRC-161" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "队列代表性、同意范围和后续数据更新机制需要持续审计。", "cross_links": [ "HIT-DEM-004", "HIT-SCI-023" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 与官方关于页交叉核验。", "created_at": "2026-08-06T20:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-041", "title": "恩格尔巴特提出人类智能增强框架", "date_start": "1962-10", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "California / North America", "path_family": "cognitive_extension", "event_type": "thought", "claim": "恩格尔巴特在 1962 年 10 月报告《增强人类智能》，把人与计算机视为一个可优化的复合系统，提出用符号工具、交互媒体和协作过程扩展人类问题求解能力。", "summary": "该报告成为人机协作、认知外延和 Human Infra 工具增强路线的奠基文本。", "sources": [ "SRC-162" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "报告是概念框架和早期设想，不是现代 AI 系统的直接实现证明。", "cross_links": [ "HIT-THT-043", "HIT-THT-022" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 Doug Engelbart Institute 原文页可达性核验。", "created_at": "2026-08-06T20:50:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-042", "title": "帕菲特《理与人》系统讨论人格同一性", "date_start": "1984", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United Kingdom", "region": "Europe", "path_family": "philosophical", "event_type": "thought", "claim": "帕菲特在 1984 年出版的《理与人》中提出人格同一性不是全有全无的实体问题，而可由心理连续性和关联性部分解释，深刻影响意识上传和数字复制伦理。", "summary": "该书为“2 号你”和主体连续性讨论提供了当代哲学基础。", "sources": [ "SRC-163" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "哲学结论不等于神经科学或技术上的身份判定标准。", "cross_links": [ "HIT-THT-030", "HIT-THT-031" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T20:50:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-043", "title": "克拉克与查默斯提出扩展心智", "date_start": "1998", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United Kingdom / Australia", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "Clark 与 Chalmers 在 1998 年发表于 Analysis 的《扩展心智》中提出，外部工具在满足可靠性、可访问性和耦合条件时可能构成认知过程的一部分。", "summary": "该论文为 AI 工具、记忆外化、数字设备和脑机接口进入“主体认知系统”提供哲学依据。", "sources": [ "SRC-164" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "扩展心智命题存在大量哲学反驳，不等于心理或神经科学已确认。", "cross_links": [ "HIT-THT-041", "HIT-THT-026" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做作者原文页可达性核验。", "created_at": "2026-08-06T20:50:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-044", "title": "查默斯对技术奇点做系统哲学分析", "date_start": "2010", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Australia / Global", "region": "Global", "path_family": "cross_path", "event_type": "thought", "claim": "Chalmers 在 2010 年发表《技术奇点：一种哲学分析》，系统讨论智能爆炸的可能性、认识条件和主体连续性问题，并把奇点从科幻叙事带入分析哲学。", "summary": "该文为奇点、上传人格和机器意识讨论提供概念工具。", "sources": [ "SRC-165" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "智能爆炸和上传的可行性仍是哲学与工程双重开放问题。", "cross_links": [ "HIT-THT-024", "HIT-THT-014" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做作者论文 PDF 可达性核验。", "created_at": "2026-08-06T20:50:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-045", "title": "博斯特罗姆出版《超级智能》", "date_start": "2014-07-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Global", "region": "Global", "path_family": "cross_path", "event_type": "thought", "claim": "Bostrom 于 2014 年 7 月 3 日出版《超级智能》，系统分析超级智能可能出现、控制与对齐问题，使 AI 风险成为未来技术治理的核心议题。", "summary": "该书把“智能爆炸与人类价值对齐”引入公共讨论，也影响长寿技术中的 AI 风险治理。", "sources": [ "SRC-166" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "书中大量场景是推理和风险分析，不是实证预测。", "cross_links": [ "HIT-THT-044", "HIT-THT-028" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T20:50:00Z", "updated_at": "2026-08-06T20:50:00Z" }, { "event_id": "HIT-MTH-008", "title": "《亡灵书》文本传统形成", "date_start": "-1550~", "date_type": "approx", "period_id": "period-ancient-egypt-new-kingdom", "civilization": "Ancient Egypt", "region": "Nile Valley", "path_family": "philosophical", "event_type": "religious", "claim": "古埃及《亡灵书》文本传统从新王国时期开始形成，汇集咒语、审判、身体保存和来世通行知识，把个体永生系统化为可抄写、可随葬的仪式文本。", "summary": "《亡灵书》把死亡之后的身份延续与日常宗教实践联系起来，是古代埃及永生观的经典表达。", "sources": [ "SRC-167" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "《亡灵书》是长期演化的文本传统，现代译本使用底本和编纂方式需要进一步复核。", "cross_links": [ "HIT-MTH-001", "HIT-SCI-025" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 译本可达性核验。", "created_at": "2026-08-06T21:10:00Z", "updated_at": "2026-08-06T21:10:00Z" }, { "event_id": "HIT-LIT-009", "title": "但丁完成《神曲》", "date_start": "1321", "date_type": "approx", "period_id": "period-latin-medieval", "civilization": "Italy", "region": "Italy / Europe", "path_family": "philosophical", "event_type": "literature", "claim": "但丁约于 1321 年完成《神曲》，以地狱、炼狱和天堂结构把个体死后命运、爱欲、政治和永恒幸福组织成宏大文学宇宙。", "summary": "《神曲》成为中世纪基督教永恒生命想象和后世灵魂叙事的重要参照。", "sources": [ "SRC-168" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "《神曲》完成年代与各篇流传存在学术讨论，1321 年为常用节点。", "cross_links": [ "HIT-THT-037", "HIT-LIT-003" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Project Gutenberg 公版书可达性核验。", "created_at": "2026-08-06T21:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-046", "title": "弗洛伊德《超越快乐原则》提出死亡本能", "date_start": "1920", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Austria", "region": "Europe", "path_family": "philosophical", "event_type": "thought", "claim": "弗洛伊德在 1920 年出版的《超越快乐原则》中提出死亡本能，认为生命活动包含向无生命状态回归的倾向，使死亡成为心理理论而非仅生物学终点。", "summary": "该文本深刻影响 20 世纪对永生愿望、重复冲动和死亡焦虑的解释。", "sources": [ "SRC-169" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "死亡本能属于精神分析理论，未经受现代实证心理科学一致验证。", "cross_links": [ "HIT-THT-047", "HIT-LIT-007" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 译本可达性核验。", "created_at": "2026-08-06T21:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-047", "title": "加缪《西西弗神话》提出死亡与意义问题", "date_start": "1942", "date_type": "approx", "period_id": "period-20th-century", "civilization": "France", "region": "Europe", "path_family": "philosophical", "event_type": "thought", "claim": "加缪在 1942 年出版的《西西弗神话》中从“人必须死”这一事实出发讨论荒谬，主张在无来世承诺的条件下持续创造意义。", "summary": "该文本构成 20 世纪存在主义对永生许诺和死亡意义的重要哲学回应。", "sources": [ "SRC-170" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "哲学立场不等于伦理学或心理学定论。", "cross_links": [ "HIT-THT-038", "HIT-LIT-007" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 英译本可达性核验。", "created_at": "2026-08-06T21:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-048", "title": "贝克尔《拒斥死亡》把死亡恐惧放入人类动机核心", "date_start": "1973", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "philosophical", "event_type": "thought", "claim": "贝克尔在 1973 年出版的《拒斥死亡》中综合精神分析与人类学，主张死亡恐惧是人类行动、英雄主义和永生象征背后的深层动机。", "summary": "该书让死亡否认成为理解永生追求和意义建构的重要心理-文化框架。", "sources": [ "SRC-171" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "书中主张是跨学科解释，不是可检验的单变量实证模型。", "cross_links": [ "HIT-THT-046", "HIT-THT-047" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 数字档案可达性核验。", "created_at": "2026-08-06T21:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-032", "title": "NIA 干预测试项目发表首份中期报告", "date_start": "2007-06-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America", "path_family": "maintenance", "event_type": "technology", "claim": "Miller 等人在 2007 年 6 月 18 日于 Aging Cell 发表 NIA Interventions Testing Program 的研究设计和中期报告，建立多实验室、遗传异质小鼠、标准化寿命实验的干预测试基础设施。", "summary": "ITP 为抗衰干预提供可比较、可复现的动物筛选平台，是 geroscience 方法学基础设施的重要节点。", "sources": [ "SRC-172" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "动物模型结果不直接等同人类疗效，ITP 覆盖的干预和品系仍在扩展。", "cross_links": [ "HIT-SCI-008", "HIT-INS-001" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-06T21:30:00Z", "updated_at": "2026-08-06T21:30:00Z" }, { "event_id": "HIT-THT-049", "title": "Geroscience 假说把衰老与慢性病统一为研究框架", "date_start": "2014-11-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "Kennedy 等人在 2014 年 11 月 1 日于 Cell 发表 Geroscience 综述，主张衰老是多种慢性病共同风险因素，并把生物学衰老研究作为疾病预防的公共议程。", "summary": "Geroscience 假说为健康寿命研究、动物模型、生物标志物和临床试验提供统一理论坐标。", "sources": [ "SRC-173" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "衰老作为共同风险因素具有强证据，但因果链和干预转化仍需持续验证。", "cross_links": [ "HIT-THT-015", "HIT-THT-040" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-06T21:30:00Z", "updated_at": "2026-08-06T21:30:00Z" }, { "event_id": "HIT-SCI-031", "title": "首个人体 senolytics 临床报告发表", "date_start": "2019-09-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Minnesota / North America", "path_family": "maintenance", "event_type": "technology", "claim": "Hickson 等人在 2019 年 9 月 18 日于 EBioMedicine 报告达沙替尼加槲皮素的人体初步试验，显示糖尿病肾病个体中衰老细胞标志物下降，是 senolytics 早期人体证据。", "summary": "该报告把清除衰老细胞从动物实验推进到人体探索，但样本量小且机制仍需确认。", "sources": [ "SRC-174" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "major", "uncertainty": "初步报告不是随机对照疗效证明，标志物下降不等于临床结局改善。", "cross_links": [ "HIT-SCI-010", "HIT-SCI-023" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T21:30:00Z", "updated_at": "2026-08-06T21:30:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-TEC-027", "title": "AlphaFold 蛋白质结构数据库覆盖 2.14 亿序列", "date_start": "2024-01-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Global", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "Varadi 等人在 2024 年 1 月 1 日于 Nucleic Acids Research 报告 AlphaFold Protein Structure Database 提供超过 2.14 亿条蛋白质序列的结构覆盖。", "summary": "大规模结构数据库把蛋白质结构从逐条实验解析转变为可扩展计算资源，支撑衰老和疾病研究基础设施。", "sources": [ "SRC-175" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "major", "uncertainty": "结构覆盖规模不等于结构质量或功能理解都已完成。", "cross_links": [ "HIT-TEC-025", "HIT-SCI-026" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T21:30:00Z", "updated_at": "2026-08-06T21:30:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-FAI-008", "title": "GSK 终止 SRT501 白藜芦醇研发", "date_start": "2010~", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United Kingdom / United States", "region": "Global", "path_family": "cross_path", "event_type": "failure", "claim": "GSK 约在 2010 年前后终止 Sirtris 旗下 SRT501 白藜芦醇制剂的进一步开发，显示“延寿分子”从市场热度到临床验证存在高失败率。", "summary": "SRT501 成为抗衰补剂和 sirtuin 热潮中的关键反证，提醒把实验室机制直接等同于人体延寿药是危险的。", "sources": [ "SRC-176", "SRC-177" ], "evidence_grade": "L", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "终止时间在不同报道中存在 2010-2011 年差异，本事件用约数记录。", "cross_links": [ "HIT-FAI-002", "HIT-FAI-006" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 与 Pharmafile 交叉核验。", "created_at": "2026-08-06T21:50:00Z", "updated_at": "2026-08-06T21:50:00Z" }, { "event_id": "HIT-FAI-009", "title": "UBX0101 senolytics II 期试验失败", "date_start": "2020-08-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "California / Global", "path_family": "maintenance", "event_type": "failure", "claim": "Unity Biotechnology 于 2020 年 8 月 17 日公布 UBX0101 II 期 12 周结果，膝骨关节炎疼痛主要终点未达到统计学显著差异，公司不再推进该药进入关键研究。", "summary": "这是首个进入 II 期的局部 senolytics 重大失败，说明清除衰老细胞概念仍需更好的靶点、剂型和终点。", "sources": [ "SRC-178" ], "evidence_grade": "L", "verification_status": "locally_reviewed", "status": "draft", "significance": "major", "uncertainty": "单一试验失败不否定其他 senolytics 策略，但该结果降低“快速转化为止痛药”的预期。", "cross_links": [ "HIT-SCI-031", "HIT-SCI-010" ], "chapter": "失败教训、监管边界与反证", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T21:50:00Z", "updated_at": "2026-08-06T21:50:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-FAI-010", "title": "FDA 恢复 NMN 作为膳食补充剂地位", "date_start": "2025-12-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "cross_path", "event_type": "failure", "claim": "美国天然产品协会于 2025 年 12 月 10 日报道，FDA 在诉讼后逆转 2022 年决定，确认烟酰胺单核苷酸可继续作为膳食补充剂销售。", "summary": "该事件显示长寿补剂同时受科学、市场和法律监管影响，也暴露 NAD 前体路线的监管不确定性。", "sources": [ "SRC-179" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "监管状态变化不证明 NMN 对人体延寿有效，也不替代临床证据审查。", "cross_links": [ "HIT-FAI-008", "HIT-FAI-006" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 NPA 官方新闻稿核验。", "created_at": "2026-08-06T21:50:00Z", "updated_at": "2026-08-06T21:50:00Z" }, { "event_id": "HIT-TEC-028", "title": "首例化学合成基因组控制的细菌细胞诞生", "date_start": "2010-05-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "Gibson 等人在 2010 年 5 月 20 日于 Science 报告，使用化学合成的基因组替换天然基因组后获得可控的细菌细胞，实现合成生物学的重要里程碑。", "summary": "该实验显示生命系统可在基因组层面被构造和替换，为合成生命与医学工程提供技术基础。", "sources": [ "SRC-181" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "合成细胞仍依赖宿主细胞结构和培养条件，不等于从头创造生命。", "cross_links": [ "HIT-TEC-004", "HIT-SCI-007" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-06T22:10:00Z", "updated_at": "2026-08-06T22:10:00Z" }, { "event_id": "HIT-SCI-033", "title": "CRISPR-Cas9 可编程基因编辑论文发表", "date_start": "2012-06-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Sweden / Global", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "Jinek 等人在 2012 年 6 月 28 日于 Science 报告，Cas9 可由双 RNA 引导进行可编程 DNA 切割，为 CRISPR 基因编辑时代奠定方法基础。", "summary": "该论文让基因组编辑从复杂蛋白工程简化为可编程 RNA 引导系统，直接支撑后续基因治疗和抗衰研究。", "sources": [ "SRC-180" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "体外机制突破不等于体内治疗安全，脱靶和递送问题仍限制临床应用。", "cross_links": [ "HIT-INS-015", "HIT-TEC-005" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T22:10:00Z", "updated_at": "2026-08-06T22:10:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-TEC-029", "title": "首例成功的人类手移植手术完成", "date_start": "1998-09-23", "date_type": "exact", "period_id": "period-20th-century", "civilization": "France / Global", "region": "Europe / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "1998 年 9 月 23 日，法国里昂团队完成首例成功的人类手移植，证明复合组织可跨越肢体缺损实现功能重建。", "summary": "该手术是身体功效替代和移植免疫控制的重要临床节点。", "sources": [ "SRC-182" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "早期手移植存在免疫抑制和长期功能风险，该事件不构成广泛治疗标准。", "cross_links": [ "HIT-TEC-009", "HIT-TEC-010" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T22:10:00Z", "updated_at": "2026-08-06T22:10:00Z" }, { "event_id": "HIT-TEC-030", "title": "首例部分面部移植手术完成", "date_start": "2005-11-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "France / Global", "region": "Europe / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2005 年 11 月 27 日，法国亚眠团队为 Isabelle Dinoire 完成世界首例活体部分面部移植，使面部功能与身份外观成为可移植对象。", "summary": "该手术推动复合组织移植伦理、身份和功能重建研究。", "sources": [ "SRC-183" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "面部移植涉及供体心理、免疫、身份和社会伦理，长期结果仍需独立审查。", "cross_links": [ "HIT-TEC-029", "HIT-TEC-009" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T22:10:00Z", "updated_at": "2026-08-06T22:10:00Z" }, { "event_id": "HIT-TEC-031", "title": "首位体外受精婴儿出生", "date_start": "1978-07-25", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United Kingdom", "region": "Oldham / Europe", "path_family": "reconstruction", "event_type": "technology", "claim": "Louise Joy Brown 于 1978 年 7 月 25 日出生，成为首位经体外受精受孕的人类，证明生殖过程可在体内外被工程化组织。", "summary": "IVF 扩大生殖和家庭形成路径，是生育保存与未来选择权研究的基础临床里程碑。", "sources": [ "SRC-184" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "IVF 解决特定不孕条件，不改变自然生殖的生物学风险或伦理复杂性。", "cross_links": [ "HIT-SCI-027", "HIT-TEC-004" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T22:10:00Z", "updated_at": "2026-08-06T22:10:00Z" }, { "event_id": "HIT-MTH-009", "title": "荷马颂歌中的得墨忒耳与永生母题形成", "date_start": "-600~", "date_type": "approx", "period_id": "period-archaic-greece", "civilization": "Ancient Greece", "region": "Aegean / Mediterranean", "path_family": "philosophical", "event_type": "myth", "claim": "《得墨忒耳颂歌》约在公元前 7-6 世纪文本化，把珀耳塞福涅的往返、死亡与再生以及永生愿望组织成希腊宗教核心叙事。", "summary": "该文本为希腊神秘宗教和“死后生命转化”母题提供重要源头。", "sources": [ "SRC-185" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "颂歌形成和表演年代存在学术争议，约公元前 7-6 世纪为常用窗口。", "cross_links": [ "HIT-MTH-006", "HIT-THT-003" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Project Gutenberg 公版译本可达性核验。", "created_at": "2026-08-06T22:30:00Z", "updated_at": "2026-08-06T22:30:00Z" }, { "event_id": "HIT-THT-050", "title": "《淮南子》整合神仙与长生思想", "date_start": "-139~", "date_type": "approx", "period_id": "period-warring-states-han", "civilization": "China", "region": "Huainan / Central China", "path_family": "philosophical", "event_type": "thought", "claim": "《淮南子》约于公元前 139 年前后成书，把道家自然观、养生、神仙想象和治理秩序整合为汉代百科全书式文本。", "summary": "该书是战国至汉代长生思想从个人修炼进入系统文献的重要节点。", "sources": [ "SRC-186" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "《淮南子》各篇成书和献书时间存在版本研究，约公元前 139 年为常用参照。", "cross_links": [ "HIT-THT-017", "HIT-THT-034" ], "chapter": "炼丹、药物与身体转化", "notes": "draft，等待来源语境复核。本轮已做 Chinese Text Project 原文可达性核验。", "created_at": "2026-08-06T22:30:00Z", "updated_at": "2026-08-06T22:30:00Z" }, { "event_id": "HIT-THT-051", "title": "《薄伽梵歌》文本形成并系统化灵魂不朽", "date_start": "-200~", "date_end": "200~", "date_type": "range", "period_id": "period-classical-india", "civilization": "India", "region": "South Asia", "path_family": "philosophical", "event_type": "thought", "claim": "《薄伽梵歌》约在公元前 2 世纪至公元 2 世纪间形成，以自我不死、业报和奉献解脱系统化印度教灵魂观。", "summary": "该文本成为“个体永恒灵魂”和“死后延续”在印度传统中最具影响力的表述之一。", "sources": [ "SRC-187" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "《薄伽梵歌》文本层形成跨度大，具体年代存在多种学术观点。", "cross_links": [ "HIT-THT-001", "HIT-THT-002" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Project Gutenberg 英译本可达性核验。", "created_at": "2026-08-06T22:30:00Z", "updated_at": "2026-08-06T22:30:00Z" }, { "event_id": "HIT-LIT-010", "title": "《西藏度亡经》文本传统形成", "date_start": "700~", "date_end": "1400~", "date_type": "long_process", "period_id": "period-medieval-tibet", "civilization": "Tibet", "region": "Tibetan Plateau", "path_family": "philosophical", "event_type": "literature", "claim": "《西藏度亡经》约在 8-14 世纪藏传佛教传统中形成，以中阴救度、死亡觉知和转世选择组织死后意识延续的修行文本。", "summary": "该文本把死亡转化为可训练、可准备的心理和精神过程，是亚洲死亡与转世文献的代表。", "sources": [ "SRC-188" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "文本作者、伏藏传统和版本分层复杂，本事件记录长时段文本传统而非单一成书年代。", "cross_links": [ "HIT-MTH-008", "HIT-THT-002" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 译本可达性核验。", "created_at": "2026-08-06T22:30:00Z", "updated_at": "2026-08-06T22:30:00Z" }, { "event_id": "HIT-THT-052", "title": "库兹韦尔与格罗斯曼出版《奇妙之旅》", "date_start": "2004", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "maintenance", "event_type": "thought", "claim": "Kurzweil 与 Grossman 在 2004 年出版《奇妙之旅》，把健康行为、医学进步和“活到能活到永远”的长寿逃逸速度概念普及给大众读者。", "summary": "该书是长寿逃逸速度从学术讨论进入公众行动框架的重要文本。", "sources": [ "SRC-189" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "书中预测和健康建议属于作者观点，不等于临床共识。", "cross_links": [ "HIT-THT-023", "HIT-THT-024" ], "chapter": "从长生术到近代延寿思想", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 数字档案可达性核验。", "created_at": "2026-08-06T22:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-POL-007", "title": "人类基因编辑国际峰会发表声明", "date_start": "2015-12-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Washington DC / Global", "path_family": "reconstruction", "event_type": "policy", "claim": "人类基因编辑国际峰会于 2015 年 12 月 3 日发表声明，呼吁在临床使用可遗传基因编辑前建立充分的安全、伦理和社会条件。", "summary": "该声明确立了生殖系基因编辑需要国际协调和暂停红线的基本治理框架。", "sources": [ "SRC-190" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "峰会声明是治理建议，不是具有法律约束力的国际条约。", "cross_links": [ "HIT-INS-015", "HIT-SCI-033" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 National Academies 官方声明可达性核验。", "created_at": "2026-08-06T22:50:00Z", "updated_at": "2026-08-06T22:50:00Z" }, { "event_id": "HIT-FAI-011", "title": "贺建奎 CRISPR 婴儿事件引发全球伦理争议", "date_start": "2018-11-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China / Global", "region": "Global", "path_family": "reconstruction", "event_type": "failure", "claim": "2018 年 11 月 26 日，贺建奎宣称通过 CRISPR 编辑人类胚胎基因并导致双胞胎出生，引发关于知情同意、生殖系编辑和科学伦理的全球危机。", "summary": "该事件成为人类生殖系基因编辑最重要的反证，推动监管收紧和国际共识强化。", "sources": [ "SRC-191" ], "evidence_grade": "S", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "相关医学后果和事件细节仍在持续审查，部分声明尚未获得独立确认。", "cross_links": [ "HIT-POL-007", "HIT-SCI-033" ], "chapter": "失败教训、监管边界与反证", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T22:50:00Z", "updated_at": "2026-08-06T22:50:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-POL-008", "title": "英国《人类受精与胚胎学法》通过", "date_start": "1990-11-01", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United Kingdom", "region": "United Kingdom", "path_family": "reconstruction", "event_type": "policy", "claim": "英国于 1990 年 11 月 1 日通过《人类受精与胚胎学法》，建立人类胚胎研究、体外受精和生殖技术许可监管框架。", "summary": "该法成为全球生殖医学和胚胎研究治理的重要制度原型。", "sources": [ "SRC-192" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "法案后续多次修订，本事件记录最初通过节点。", "cross_links": [ "HIT-TEC-031", "HIT-POL-007" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 legislation.gov.uk 原文可达性核验。", "created_at": "2026-08-06T22:50:00Z", "updated_at": "2026-08-06T22:50:00Z" }, { "event_id": "HIT-INS-021", "title": "FDA 批准首个美国基因疗法 Luxturna", "date_start": "2017-12-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "reconstruction", "event_type": "institution", "claim": "FDA 于 2017 年 12 月 19 日批准 Luxturna，成为美国首个治疗遗传性视网膜疾病的基因疗法。", "summary": "Luxturna 确立了体内基因替代疗法进入临床监管的路径。", "sources": [ "SRC-193" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "批准针对特定单基因疾病，不代表基因疗法普遍适用于复杂疾病。", "cross_links": [ "HIT-INS-016", "HIT-TEC-005" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 FDA 新闻稿 Internet Archive 存档核验。", "created_at": "2026-08-06T22:50:00Z", "updated_at": "2026-08-06T22:50:00Z" }, { "event_id": "HIT-INS-022", "title": "EMA 授权首个欧盟基因疗法 Glybera", "date_start": "2012-10-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "European Union / Global", "region": "Europe / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "欧盟委员会于 2012 年 10 月 25 日授权 Glybera，成为欧盟首个基因治疗药物，用于家族性脂蛋白脂酶缺乏症成人患者。", "summary": "Glybera 是基因疗法商业化的重要早期监管案例，但因需求有限未续期。", "sources": [ "SRC-194" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该药上市后未申请续期并于 2017 年到期，说明批准不等于商业可持续。", "cross_links": [ "HIT-INS-021", "HIT-INS-016" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 EMA EPAR 页面核验。", "created_at": "2026-08-06T22:50:00Z", "updated_at": "2026-08-06T22:50:00Z" }, { "event_id": "HIT-TEC-032", "title": "BrainGate 首次证明人脑可控制外部设备", "date_start": "2006-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Rhode Island / North America", "path_family": "cognitive_extension", "event_type": "technology", "claim": "Hochberg 等人在 2006 年 7 月 1 日于 Nature 报告，一名四肢瘫痪者通过皮层内电极阵列控制机械和电脑光标，展示长期侵入式脑机接口的人体可行性。", "summary": "BrainGate 是侵入式 BCI 从动物进入人体的代表性证据。", "sources": [ "SRC-195" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "样本为单例早期试验，长期稳定性、安全性和普及性仍需大量验证。", "cross_links": [ "HIT-TEC-011", "HIT-THT-026" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-06T23:10:00Z", "updated_at": "2026-08-06T23:10:00Z" }, { "event_id": "HIT-TEC-033", "title": "FDA 批准 Argus II 视网膜假体", "date_start": "2013-02-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "FDA 于 2013 年 2 月 14 日批准 Argus II 视网膜假体，成为美国首个获批的商用视网膜植入装置。", "summary": "Argus II 证明感觉神经假体可进入正式监管和治疗路径，为脑机接口和感官修复提供制度原型。", "sources": [ "SRC-196" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "装置只针对特定视网膜退化患者，视觉改善范围和长期效果有限。", "cross_links": [ "HIT-TEC-032", "HIT-TEC-011" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T23:10:00Z", "updated_at": "2026-08-06T23:10:00Z" }, { "event_id": "HIT-TEC-034", "title": "Neuralink 完成首例人体脑机接口植入", "date_start": "2024-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "California / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "Neuralink 于 2024 年 1 月完成其 PRIME 研究的首例人体脑机接口植入，并在术后检测到参与者神经信号。", "summary": "该事件标志商用高通道侵入式 BCI 进入早期人体试验阶段，但仍是研究性装置。", "sources": [ "SRC-197" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "官方更新只披露 1 月完成首例植入，未给出精确日期和完整安全性数据。", "cross_links": [ "HIT-TEC-011", "HIT-TEC-032" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 Neuralink 官方更新页核验。", "created_at": "2026-08-06T23:10:00Z", "updated_at": "2026-08-06T23:10:00Z" }, { "event_id": "HIT-INS-023", "title": "美国启动 BRAIN Initiative", "date_start": "2013-04-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Washington DC / Global", "path_family": "cognitive_extension", "event_type": "institution", "claim": "美国白宫于 2013 年 4 月 2 日公布 BRAIN Initiative，把脑活动图谱和神经技术开发上升为国家科研基础设施。", "summary": "BRAIN Initiative 推动神经记录、脑机接口和神经计算工具的基础设施化。", "sources": [ "SRC-198" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "计划目标随时间扩展，项目成果和资金规模需持续核验。", "cross_links": [ "HIT-INS-001", "HIT-TEC-011" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做白宫官方事实页核验。", "created_at": "2026-08-06T23:10:00Z", "updated_at": "2026-08-06T23:10:00Z" }, { "event_id": "HIT-POL-009", "title": "欧盟人工智能法案生效", "date_start": "2024-08-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "European Union", "region": "Europe / Global", "path_family": "cross_path", "event_type": "policy", "claim": "欧盟《人工智能法案》于 2024 年 8 月 1 日生效，建立以风险分级为基础的 AI 监管框架，影响 AI 驱动的健康、长寿和生物技术治理。", "summary": "EU AI Act 是首个大型司法辖区系统化 AI 法规，也为 AI 医学和抗衰技术设定合规边界。", "sources": [ "SRC-199" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "法案分阶段适用，具体义务和豁免需按时间表持续跟踪。", "cross_links": [ "HIT-POL-006", "HIT-THT-028" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 EUR-Lex 官方法规页核验。", "created_at": "2026-08-06T23:10:00Z", "updated_at": "2026-08-06T23:10:00Z" }, { "event_id": "HIT-THT-053", "title": "桑德伯格与博斯特罗姆发表《全脑仿真路线图》", "date_start": "2008", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United Kingdom", "region": "Oxford / Global", "path_family": "digital_migration", "event_type": "thought", "claim": "Sandberg 与 Bostrom 在 2008 年发表《全脑仿真路线图》，把意识上传拆解为数据采集、建模、仿真和验证等技术步骤，为数字迁移提供工程化路线。", "summary": "该路线图让 mind uploading 从哲学设想进入可讨论的技术路径。", "sources": [ "SRC-200" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "路线图是技术推测，不证明全脑仿真的工程可行性。", "cross_links": [ "HIT-THT-014", "HIT-THT-044" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 ORA 官方存档可达性核验。", "created_at": "2026-08-06T23:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-035", "title": "线虫完整神经连接组发表", "date_start": "1986-11", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United Kingdom", "region": "Cambridge / Europe", "path_family": "digital_migration", "event_type": "technology", "claim": "White 等人在 1986 年 11 月于 Philosophical Transactions of the Royal Society B 发表秀丽隐杆线虫完整神经连接组，成为 connectomics 的奠基性工作。", "summary": "首个全连接组为数字迁移和神经模拟提供可复核的底层数据对象。", "sources": [ "SRC-201" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "线虫连接组不等于人类大脑仿真，结构数据仍需功能验证。", "cross_links": [ "HIT-TEC-018", "HIT-THT-053" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-06T23:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-024", "title": "艾伦脑科学研究所成立", "date_start": "2003", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Seattle / North America", "path_family": "cognitive_extension", "event_type": "institution", "claim": "艾伦脑科学研究所于 2003 年由 Paul Allen 创立，以开放脑图谱和神经数据基础设施为核心，推动脑科学数据成为公共研究资源。", "summary": "该研究所为脑图谱、细胞类型和神经连接数据建立机构化生产管线。", "sources": [ "SRC-202" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "机构成立事实清楚，具体数据覆盖和影响需持续核验。", "cross_links": [ "HIT-INS-023", "HIT-TEC-018" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 与官方页面交叉核验。", "created_at": "2026-08-06T23:30:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-025", "title": "人类连接组计划启动", "date_start": "2009-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "digital_migration", "event_type": "institution", "claim": "人类连接组计划约于 2009 年 7 月启动，旨在通过神经影像绘制健康人脑结构和功能连接网络。", "summary": "该计划把“脑连接”转化为可采集、可共享、可建模的大规模数据基础设施。", "sources": [ "SRC-203" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "项目启动日期在不同来源中略有差异，本事件以 2009 年 7 月记录。", "cross_links": [ "HIT-INS-023", "HIT-TEC-018" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 HCP 官方站点核验。", "created_at": "2026-08-06T23:30:00Z", "updated_at": "2026-08-06T23:30:00Z" }, { "event_id": "HIT-INS-026", "title": "人类脑计划启动", "date_start": "2013-10-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "European Union", "region": "Europe / Global", "path_family": "cognitive_extension", "event_type": "institution", "claim": "人类脑计划于 2013 年 10 月 1 日启动，作为欧盟未来与新兴技术旗舰项目，目标是把脑科学、计算模拟和医学数据整合为大型研究基础设施。", "summary": "HBP 是欧洲把全脑建模和神经信息学制度化的重要尝试。", "sources": [ "SRC-204" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "HBP 成果与“全脑仿真”承诺之间存在差距，项目已于 2023 年结束。", "cross_links": [ "HIT-INS-023", "HIT-THT-053" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T23:30:00Z", "updated_at": "2026-08-06T23:30:00Z" }, { "event_id": "HIT-THT-054", "title": "奥洛夫尼科夫提出端粒边际切除理论", "date_start": "1973-09-14", "date_type": "exact", "period_id": "period-20th-century", "civilization": "Soviet Union", "region": "Soviet Union / International", "path_family": "maintenance", "event_type": "thought", "claim": "Olovnikov 在 1973 年提出 marginotomy 理论，认为 DNA 末端的不完全复制限制细胞分裂次数，为端粒缩短与复制衰老建立理论桥梁。", "summary": "该理论把“细胞为何停止分裂”从现象观察推进为分子末端复制机制假设。", "sources": [ "SRC-205" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "端粒与衰老的因果关系仍需分层验证，理论不能直接推出治疗用途。", "cross_links": [ "HIT-SCI-003", "HIT-SCI-005" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-06T23:50:00Z", "updated_at": "2026-08-06T23:50:00Z" }, { "event_id": "HIT-THT-055", "title": "柯克伍德提出一次性体细胞理论", "date_start": "1977-11-24", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United Kingdom", "region": "United Kingdom / International", "path_family": "maintenance", "event_type": "thought", "claim": "Kirkwood 在 1977 年 Nature 发表《Evolution of ageing》，提出一次性体细胞理论，认为衰老来自生殖投入与体细胞维护之间的资源权衡。", "summary": "该理论为解释寿命差异和衰老可塑性提供进化生态学基础。", "sources": [ "SRC-206" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "资源权衡是理论框架，具体分子机制和干预后果仍需实证。", "cross_links": [ "HIT-THT-011", "HIT-THT-012", "HIT-THT-019" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-06T23:50:00Z", "updated_at": "2026-08-06T23:50:00Z" }, { "event_id": "HIT-SCI-035", "title": "PhenoAge 表观遗传年龄标志物发表", "date_start": "2018-04-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "United States / Global", "path_family": "maintenance", "event_type": "technology", "claim": "Levine 等人在 2018 年发表 PhenoAge，用 DNA 甲基化与临床表型构建可预测寿命和健康寿命的表观遗传年龄标志物。", "summary": "PhenoAge 把生物年龄从“时间刻度”扩展为可检验的死亡与健康风险指标。", "sources": [ "SRC-207" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "major", "uncertainty": "生物年龄指标是统计预测器，不等同于衰老因果机制或临床诊断结论。", "cross_links": [ "HIT-SCI-009", "HIT-SCI-019", "HIT-SCI-036" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T23:50:00Z", "updated_at": "2026-08-06T23:50:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-SCI-036", "title": "GrimAge 寿命与健康寿命预测标志物发表", "date_start": "2019-01-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "United States / Global", "path_family": "maintenance", "event_type": "technology", "claim": "Lu 等人在 2019 年发表 GrimAge，利用 DNA 甲基化替代指标预测 lifespan 和 healthspan，强化死亡风险与生物年龄的可测量连接。", "summary": "GrimAge 成为健康寿命研究中常用的表观遗传风险指标。", "sources": [ "SRC-208" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "major", "uncertainty": "GrimAge 预测关联强，但因果关系、跨人群校准和临床用途仍需独立复核。", "cross_links": [ "HIT-SCI-009", "HIT-SCI-019", "HIT-SCI-035" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T23:50:00Z", "updated_at": "2026-08-06T23:50:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-INS-030", "title": "玛土撒拉基金会更名并进入长寿研究资助", "date_start": "2003", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Virginia / North America", "path_family": "social_composite", "event_type": "institution", "claim": "Methuselah Foundation 于 2003 年由 David Gobel、Aubrey de Grey 和 Dane Gobel 完成更名，并通过 Mprize 等机制资助延寿与组织修复研究。", "summary": "该基金会把“延长健康寿命”转化为可资助、可竞赛、可追踪的研究基础设施。", "sources": [ "SRC-209" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "更名与组织成立年份在不同来源中表述略有差异，本事件记录 2003 年更名节点。", "cross_links": [ "HIT-INS-018", "HIT-THT-023", "HIT-INS-012" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T23:50:00Z", "updated_at": "2026-08-06T23:50:00Z" }, { "event_id": "HIT-LIT-011", "title": "吉布森出版《神经漫游者》", "date_start": "1984-07-01", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States / Canada", "region": "North America / Global", "path_family": "digital_migration", "event_type": "literature", "claim": "William Gibson 在 1984 年出版《神经漫游者》，通过赛博空间、数字意识和人工智能叙事，把“人的模式可进入计算机”变成大众文化常识。", "summary": "《神经漫游者》为数字永生和意识上传提供了具有文化影响力的叙事框架。", "sources": [ "SRC-210" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "作品是虚构叙事，不构成技术预测或可行路径证据。", "cross_links": [ "HIT-THT-044", "HIT-THT-053", "HIT-LIT-012" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T23:55:00Z", "updated_at": "2026-08-06T23:55:00Z" }, { "event_id": "HIT-LIT-012", "title": "《攻壳机动队》开始连载", "date_start": "1989-05", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Japan", "region": "Japan / Global", "path_family": "digital_migration", "event_type": "literature", "claim": "士郎正宗《攻壳机动队》于 1989 年 5 月开始连载，系统讨论义体化、电子脑、ghost 与意识连续性问题。", "summary": "该作品把“身体可替换、意识可复制”的主题带入主流视觉文化。", "sources": [ "SRC-211" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "连载与单行本日期不同，本事件以 1989 年 5 月开始连载记录。", "cross_links": [ "HIT-LIT-011", "HIT-THT-044", "HIT-THT-053" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T23:55:00Z", "updated_at": "2026-08-06T23:55:00Z" }, { "event_id": "HIT-LIT-013", "title": "伊根出版《置换城市》", "date_start": "1994", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Australia", "region": "Australia / Global", "path_family": "digital_migration", "event_type": "literature", "claim": "Greg Egan 在 1994 年出版《置换城市》，用计算机模拟人和自我复制主体讨论身份连续性、上传和多重存在的哲学后果。", "summary": "该小说把“复制主体是否还是同一个主体”从思想实验扩展为叙事实验。", "sources": [ "SRC-212" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "作品是虚构叙事，不构成意识上传可行性证明。", "cross_links": [ "HIT-THT-042", "HIT-THT-044", "HIT-THT-053" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T23:55:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-056", "title": "库兹韦尔出版《灵魂机器的时代》", "date_start": "1999-01-01", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "United States / Global", "path_family": "digital_migration", "event_type": "thought", "claim": "Ray Kurzweil 在 1999 年出版《灵魂机器的时代》，把“人类是模式而非原子”“我们最终将变成软件并定期备份”整合为技术预言。", "summary": "该书把加速回报定律与数字永生、脑机接口和纳米技术连成统一的未来叙事。", "sources": [ "SRC-213" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "书中内容是作者预测，不是已验证事实或工程方案。", "cross_links": [ "HIT-THT-024", "HIT-THT-052", "HIT-THT-053" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T23:55:00Z", "updated_at": "2026-08-06T23:55:00Z" }, { "event_id": "HIT-LIT-015", "title": "摩根出版《副本》", "date_start": "2002-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom", "region": "United Kingdom / Global", "path_family": "digital_migration", "event_type": "literature", "claim": "Richard K. Morgan 在 2002 年出版《副本》，以意识数字化、身体“袖套”和死后重载设定，把相对永生与社会不平等绑定。", "summary": "《副本》让“数字化备份不是人人平等”成为数字永生批判性叙事。", "sources": [ "SRC-214" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "作品是虚构叙事，不构成数字迁移技术路线。", "cross_links": [ "HIT-THT-044", "HIT-THT-053", "HIT-LIT-013" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T23:55:00Z", "updated_at": "2026-08-06T23:55:00Z" }, { "event_id": "HIT-MTH-010", "title": "奥尔菲斯金箔形成死后道路文本传统", "date_start": "-400~", "date_type": "approx", "period_id": "period-classical-greece", "civilization": "Ancient Greece", "region": "Thessaly / Magna Graecia / Mediterranean", "path_family": "philosophical", "event_type": "religious", "claim": "约公元前 4 世纪起，奥尔菲斯金箔以死后通行证形式指导灵魂记住真实身份并选择神圣道路，把永生表达为个体记忆和来世行动。", "summary": "金箔把“永生”从抽象神学转化为可随葬、可朗读、可执行的个人来世技术文本。", "sources": [ "SRC-215" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "金箔年代和教派归属存在学术争议，本文按 4 世纪 BCE 普遍案例记录。", "cross_links": [ "HIT-MTH-009", "HIT-THT-003" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:00:00Z", "updated_at": "2026-08-07T00:00:00Z" }, { "event_id": "HIT-MTH-011", "title": "《但以理书》形成身体复活启示文本", "date_start": "-167~", "date_end": "-164~", "date_type": "range", "period_id": "period-late-antiquity", "civilization": "Judea / Seleucid Empire", "region": "Judea / Eastern Mediterranean", "path_family": "philosophical", "event_type": "religious", "claim": "《但以理书》在公元前 167-164 年前后完成，其中 12:2 明确表达“睡在尘埃中的必有多人复醒，得永生或受永远羞辱”，成为早期犹太身体复活观的关键文本。", "summary": "该文本把永生从个体灵魂问题转化为历史终局和身体复活的集体神学。", "sources": [ "SRC-216" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "文本形成时间按主流圣经学术共识记录，具体章节层存在形成过程差异。", "cross_links": [ "HIT-MTH-003", "HIT-MTH-012" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:00:00Z", "updated_at": "2026-08-07T00:00:00Z" }, { "event_id": "HIT-MTH-012", "title": "第二圣殿犹太教发展身体复活教义", "date_start": "-200~", "date_end": "100~", "date_type": "range", "period_id": "period-late-antiquity", "civilization": "Judea", "region": "Judea / Eastern Mediterranean", "path_family": "philosophical", "event_type": "religious", "claim": "第二圣殿时期犹太教在《但以理书》、马加比文献和法利赛传统中发展出身体复活教义，与灵魂不朽并列为后世犹太教和基督教末世论来源。", "summary": "身体复活把“死亡后主体是否继续”转化为可争论的教义、伦理和社会身份问题。", "sources": [ "SRC-217" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "不同文献对复活对象、身体与灵魂的关系存在分歧，不能统一为单一教义。", "cross_links": [ "HIT-MTH-011", "HIT-MTH-003", "HIT-MTH-002" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:00:00Z", "updated_at": "2026-08-07T00:00:00Z" }, { "event_id": "HIT-MTH-013", "title": "《诗体埃达》整理诸神黄昏叙事", "date_start": "1200~", "date_end": "1300~", "date_type": "range", "period_id": "period-latin-medieval", "civilization": "Iceland / Norse tradition", "region": "Iceland / Northern Europe", "path_family": "philosophical", "event_type": "myth", "claim": "《诗体埃达》在 13 世纪整理更早的北欧口头传统，把诸神黄昏描述为众神死亡、世界毁灭与少数神明重生，构成循环式永恒更新神话。", "summary": "诸神黄昏把永生问题置于“世界是否终将重启”的宇宙尺度上。", "sources": [ "SRC-218" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "文本抄写年代与口头传统年代不同，本文记录埃达整理期而非传说起源期。", "cross_links": [ "HIT-MTH-006", "HIT-MTH-009" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:00:00Z", "updated_at": "2026-08-07T00:00:00Z" }, { "event_id": "HIT-MTH-014", "title": "阿弥陀佛净土思想在印度大乘文本中形成", "date_start": "1~", "date_end": "200~", "date_type": "range", "period_id": "period-classical-india", "civilization": "India / Central Asia", "region": "India / Central Asia / East Asia", "path_family": "philosophical", "event_type": "religious", "claim": "约公元 1-2 世纪，《无量寿经》等大乘文本形成阿弥陀佛与净土观念，承诺众生可转生到无苦的净土并继续修行，把永生转化为救度性来世路径。", "summary": "净土思想让“延续生命”从自力修行扩展到信仰、记忆和集体往生。", "sources": [ "SRC-219" ], "evidence_grade": "M", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "净土经文本形成年代和地域存在争议，本文按 1-2 世纪 CE 学术共识记录。", "cross_links": [ "HIT-THT-001", "HIT-THT-051" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:00:00Z", "updated_at": "2026-08-07T00:00:00Z" }, { "event_id": "HIT-LIT-016", "title": "奥克西林库斯纸草开始出土并出版", "date_start": "1896", "date_end": "1898", "date_type": "range", "period_id": "period-19th-century", "civilization": "Egypt / United Kingdom", "region": "Oxyrhynchus / Egypt / Global", "path_family": "philosophical", "event_type": "literature", "claim": "Grenfell 与 Hunt 于 1896-1897 年在奥克西林库斯发现大量希腊纸草，1898 年出版第一卷，为早期基督教、荷马史诗和古代永生思想提供直接文本证据。", "summary": "奥克西林库斯纸草把“古代文本”变成可核查、可比较、可长期保存的文献基础设施。", "sources": [ "SRC-220" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "纸草发现与出版是长期过程，本文以 1896-1898 年首次发现和出版为节点。", "cross_links": [ "HIT-MTH-008", "HIT-LIT-017" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:05:00Z", "updated_at": "2026-08-07T00:05:00Z" }, { "event_id": "HIT-LIT-017", "title": "纳格哈马迪文库被发现", "date_start": "1945", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Egypt", "region": "Upper Egypt / Global", "path_family": "philosophical", "event_type": "literature", "claim": "1945 年在纳格哈马迪发现 12 部科普特语抄本，包括《多马福音》等 52 篇文本，为早期基督教、诺斯替主义和死后永生观念提供原始文献。", "summary": "纳格哈马迪文库使非正统基督教永生和救赎思想重新进入可研究的文本谱系。", "sources": [ "SRC-221" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "发现年份存在 1945 年末到学者 1946 年才知悉的表述差异。", "cross_links": [ "HIT-MTH-003", "HIT-LIT-016" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:05:00Z", "updated_at": "2026-08-07T00:05:00Z" }, { "event_id": "HIT-LIT-018", "title": "死海古卷首批卷轴被发现", "date_start": "1946", "date_end": "1947", "date_type": "range", "period_id": "period-20th-century", "civilization": "West Bank / Jordan", "region": "Qumran / Judaean Desert / Global", "path_family": "philosophical", "event_type": "literature", "claim": "死海古卷首批卷轴于 1946-1947 年在库姆兰洞穴被发现，后经 1948-1956 年持续发掘，为第二圣殿犹太教的末世论、复活和永生思想提供最早实物文本。", "summary": "死海古卷把“永生是否来自群体信仰”重新放进可检验的古代文本传统。", "sources": [ "SRC-222" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "首批发现时间在 1946 年 11 月至 1947 年 2 月之间，本文按区间记录。", "cross_links": [ "HIT-MTH-011", "HIT-MTH-012", "HIT-LIT-019" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:05:00Z", "updated_at": "2026-08-07T00:05:00Z" }, { "event_id": "HIT-LIT-019", "title": "库姆兰第四洞穴出土最大古卷库", "date_start": "1952-09", "date_type": "approx", "period_id": "period-20th-century", "civilization": "West Bank / Jordan", "region": "Qumran / Judaean Desert", "path_family": "philosophical", "event_type": "literature", "claim": "库姆兰 4Q 洞穴于 1952 年 9 月被贝都因人发现，出土约 1.6 万片残卷，约占库姆兰古卷四分之三，极大扩展第二圣殿时期文本证据。", "summary": "4Q 残卷使死海古卷从少数卷轴扩展为可系统重建的文本库。", "sources": [ "SRC-223" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "残卷数量和具体内容仍在持续出版与修订。", "cross_links": [ "HIT-LIT-018", "HIT-MTH-012" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:05:00Z", "updated_at": "2026-08-07T00:05:00Z" }, { "event_id": "HIT-INS-031", "title": "圣书之龛建成", "date_start": "1965", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Israel", "region": "Jerusalem / Israel", "path_family": "philosophical", "event_type": "institution", "claim": "圣书之龛于 1965 年在以色列博物馆建成，专门保存和公开展示死海古卷，把永生文本的保存变成国家级文化基础设施。", "summary": "圣书之龛代表“永生观念的物质证据”被制度化保存与传播。", "sources": [ "SRC-224" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "建筑年份事实清楚，收藏、数字化和访问范围需持续核验。", "cross_links": [ "HIT-LIT-018", "HIT-LIT-019" ], "chapter": "神话、来世与灵魂不朽", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:05:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-057", "title": "费曼发表《底部还有大量空间》", "date_start": "1959-12-29", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "Pasadena / United States / Global", "path_family": "reconstruction", "event_type": "thought", "claim": "Richard Feynman 于 1959 年 12 月 29 日在美国物理学会演讲《底部还有大量空间》，提出直接在原子尺度操纵物质的可能性，成为纳米技术想象的重要源头。", "summary": "该演讲把“分子级工程”从科幻边缘带入严肃科学议程。", "sources": [ "SRC-225" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "演讲当时影响力有限，1980 年代后被重新追溯为纳米技术源头。", "cross_links": [ "HIT-THT-058", "HIT-THT-059" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:10:00Z", "updated_at": "2026-08-07T00:10:00Z" }, { "event_id": "HIT-THT-058", "title": "德雷克斯勒出版《创造的引擎》", "date_start": "1986", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "United States / Global", "path_family": "reconstruction", "event_type": "thought", "claim": "K. Eric Drexler 在 1986 年出版《创造的引擎》，提出分子纳米技术、组装器和自我复制制造，把纳米机器人从思想实验变成工程议程。", "summary": "该书让“分子级修复与制造”成为未来技术讨论的核心概念。", "sources": [ "SRC-226" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "书中是工程预见，分子组装器尚未实现，需与已实现纳米材料区分。", "cross_links": [ "HIT-THT-057", "HIT-THT-059", "HIT-THT-023" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-059", "title": "德雷克斯勒出版《纳米系统》", "date_start": "1992", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "United States / Global", "path_family": "reconstruction", "event_type": "thought", "claim": "K. Eric Drexler 在 1992 年出版《纳米系统：分子机械、制造与计算》，把分子纳米技术从愿景规范为机械设计、制造和计算分析框架。", "summary": "《纳米系统》为“分子级身体修复和物质制造”提供更严格的工程语言。", "sources": [ "SRC-227" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "理论设计不等于现实制造能力，分子机械路径仍面临物理和工程约束。", "cross_links": [ "HIT-THT-057", "HIT-THT-058", "HIT-THT-060" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-060", "title": "弗雷塔斯出版《纳米医学》第一卷", "date_start": "1999", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "United States / Global", "path_family": "reconstruction", "event_type": "thought", "claim": "Robert A. Freitas Jr. 在 1999 年出版《纳米医学》第一卷，系统定义医用纳米机器人诊断、修复和增强身体的基本能力。", "summary": "《纳米医学》把纳米机器人从一般设想转化为面向人体维护的医学工程框架。", "sources": [ "SRC-228" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该书是理论能力目录，不是当前临床可行性证明。", "cross_links": [ "HIT-THT-058", "HIT-THT-059", "HIT-THT-023" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做官方目录页核验。", "created_at": "2026-08-07T00:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-061", "title": "德雷克斯勒出版《富足激进》", "date_start": "2013", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "reconstruction", "event_type": "thought", "claim": "K. Eric Drexler 在 2013 年出版《富足激进》，主张原子级精确制造可能大幅降低物质生产成本，并把纳米技术重新定位为可扩展制造基础设施。", "summary": "《富足激进》把纳米技术从寿命修复扩展到资源、能源和物质文明重建。", "sources": [ "SRC-229" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "原子级制造仍处研究前沿，成本和规模预测属于远期设想。", "cross_links": [ "HIT-THT-058", "HIT-THT-059", "HIT-THT-023" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做出版方页面核验。", "created_at": "2026-08-07T00:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-037", "title": "佩托悖论论文发表", "date_start": "1975-10-01", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United Kingdom", "region": "United Kingdom / Global", "path_family": "maintenance", "event_type": "technology", "claim": "Peto 等人在 1975 年 10 月发表《Cancer and ageing in mice and men》，指出大型长寿动物并未按体型对应地增加癌症风险，形成佩托悖论。", "summary": "佩托悖论把“体型、寿命、癌症风险”的关系变成解释长寿机制的核心问题。", "sources": [ "SRC-230" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "悖论解释仍不唯一，涉及肿瘤抑制、免疫和代谢等多重机制。", "cross_links": [ "HIT-THT-055", "HIT-THT-011", "HIT-THT-012" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Europe PMC 核验。", "created_at": "2026-08-07T00:15:00Z", "updated_at": "2026-08-07T00:15:00Z" }, { "event_id": "HIT-THT-062", "title": "炎症衰老概念提出", "date_start": "2000-06-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Italy / International", "region": "Europe / Global", "path_family": "maintenance", "event_type": "thought", "claim": "Franceschi 等人在 2000 年提出 inflamm-aging 概念，把慢性低度炎症视为免疫衰老与多种年龄相关疾病之间的进化性共同机制。", "summary": "炎症衰老把免疫系统从“清除病原体”扩展为解释寿命差异的全身调节系统。", "sources": [ "SRC-231" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "概念有解释力，但炎症与衰老的因果方向和可干预性仍需分层验证。", "cross_links": [ "HIT-THT-055", "HIT-SCI-038", "HIT-THT-063" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Europe PMC 核验。", "created_at": "2026-08-07T00:15:00Z", "updated_at": "2026-08-07T00:15:00Z" }, { "event_id": "HIT-THT-063", "title": "氧化应激与衰老生物学综述发表", "date_start": "2000-11-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "maintenance", "event_type": "thought", "claim": "Finkel 与 Holbrook 在 2000 年 Nature 发表综述，把氧化应激从单纯损伤理论发展为信号、修复与衰老之间的复杂平衡。", "summary": "该综述修正了自由基理论，强调氧化还原信号在衰老中的作用。", "sources": [ "SRC-232" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "氧化应激与衰老的因果方向和抗氧化干预价值仍需实证。", "cross_links": [ "HIT-SCI-002", "HIT-THT-019", "HIT-THT-055" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Europe PMC 核验。", "created_at": "2026-08-07T00:15:00Z", "updated_at": "2026-08-07T00:15:00Z" }, { "event_id": "HIT-SCI-038", "title": "p16INK4a 作为衰老生物标志物发表", "date_start": "2004-11-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "maintenance", "event_type": "technology", "claim": "Krishnamurthy 等人在 2004 年 11 月发表研究，证明 Ink4a/Arf 表达随年龄上升，可把细胞衰老标志物用于组织年龄估计。", "summary": "p16INK4a 为衰老细胞负荷提供了可测量、可跟踪的分子入口。", "sources": [ "SRC-233" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "标志物不等于因果靶点，组织差异和临床转化仍需校准。", "cross_links": [ "HIT-SCI-003", "HIT-SCI-010", "HIT-SCI-039" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Europe PMC 核验。", "created_at": "2026-08-07T00:15:00Z", "updated_at": "2026-08-07T00:15:00Z" }, { "event_id": "HIT-SCI-039", "title": "衰老相关分泌表型论文发表", "date_start": "2008-12-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "maintenance", "event_type": "technology", "claim": "Coppé 等人在 2008 年 12 月发表论文，系统证明衰老细胞通过分泌因子影响邻近细胞，形成衰老相关分泌表型 SASP。", "summary": "SASP 使衰老细胞从“停止增殖”扩展为可传播炎症和组织功能障碍的细胞状态。", "sources": [ "SRC-234" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "SASP 成分、组织特异性和清除策略的长期影响仍需严格验证。", "cross_links": [ "HIT-SCI-031", "HIT-SCI-038", "HIT-SCI-010" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。本轮已做 Crossref 日期核验。", "created_at": "2026-08-07T00:15:00Z", "updated_at": "2026-08-07T00:15:00Z" }, { "event_id": "HIT-THT-064", "title": "克莱因斯与克莱因提出赛博格概念", "date_start": "1960-09", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "Clynes 与 Kline 在 1960 年 9 月发表《Cyborgs and Space》，首次把赛博格定义为“自我调节的人机系统”，为太空生存和人体增强提供术语。", "summary": "赛博格概念让“人+机器”从科幻形象变成工程和研究对象。", "sources": [ "SRC-235" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该文是概念奠基，不构成具体人体增强方案。", "cross_links": [ "HIT-THT-041", "HIT-THT-065" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 MIT 原文 PDF 核验。", "created_at": "2026-08-07T00:20:00Z", "updated_at": "2026-08-07T00:20:00Z" }, { "event_id": "HIT-THT-065", "title": "哈拉维发表《赛博格宣言》", "date_start": "1985", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "Donna Haraway 于 1985 年发表《赛博格宣言》，提出人与机器、自然与文化边界已不可维持，赛博格成为身份批判和技术想象的核心隐喻。", "summary": "该宣言把赛博格从工程概念扩展为后人类身份和社会理论。", "sources": [ "SRC-236" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "文本是批判性理论，不提供人体增强技术路线。", "cross_links": [ "HIT-THT-064", "HIT-THT-042" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:20:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-066", "title": "博斯特罗姆发布超人类主义 FAQ", "date_start": "1998", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Sweden / Global", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "Nick Bostrom 于 1998 年前后发布《超人类主义 FAQ》，系统定义增强人类能力、延寿、智能扩展和风险治理的纲领。", "summary": "该 FAQ 把超人类主义从松散思想整理为可讨论的公开文档。", "sources": [ "SRC-237" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "文档经过多版本更新，本文按最初发布年代记录。", "cross_links": [ "HIT-THT-013", "HIT-THT-022", "HIT-THT-068" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做官方 PDF 核验。", "created_at": "2026-08-07T00:20:00Z", "updated_at": "2026-08-07T00:20:00Z" }, { "event_id": "HIT-THT-067", "title": "哈贝马斯出版《人类本性的未来》", "date_start": "2003", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Germany", "region": "Germany / Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "Jürgen Habermas 于 2003 年出版《人类本性的未来》，讨论基因增强和自由优生对自主性、人性和伦理的挑战。", "summary": "该书把人体增强从技术预言拉回政治哲学和规范伦理。", "sources": [ "SRC-238" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "书中立场是规范性论证，不是技术可行性判断。", "cross_links": [ "HIT-THT-032", "HIT-THT-066" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做出版方页面核验。", "created_at": "2026-08-07T00:20:00Z", "updated_at": "2026-08-07T00:20:00Z" }, { "event_id": "HIT-THT-068", "title": "博斯特罗姆发表《我为什么想长大后成为后人类》", "date_start": "2008", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Sweden / Global", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "Nick Bostrom 于 2008 年前后发表《我为什么想长大后成为后人类》，主张认知、健康和寿命增强本身具有内在价值，而不只是工具价值。", "summary": "该文为后人类增强提供价值论辩护，影响超人类主义伦理讨论。", "sources": [ "SRC-239" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "文中是价值论主张，不构成技术时间表。", "cross_links": [ "HIT-THT-066", "HIT-THT-023", "HIT-THT-045" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已做官方 PDF 核验。", "created_at": "2026-08-07T00:20:00Z", "updated_at": "2026-08-07T00:20:00Z" }, { "event_id": "HIT-INS-032", "title": "阿尔科生命延续基金会成立", "date_start": "1972", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "California / North America / Global", "path_family": "suspension", "event_type": "institution", "claim": "Fred 与 Linda Chamberlain 于 1972 年在美国加州成立 Alcor Society for Solid State Hypothermia，后更名为 Alcor Life Extension Foundation，把人体验存制度化。", "summary": "Alcor 成为全球最重要的长期体验存机构之一，也把冷冻保存带入公共治理讨论。", "sources": [ "SRC-240" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "成立年份事实清楚，保存人数和长期结果需持续核验。", "cross_links": [ "HIT-TEC-003", "HIT-INS-033" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:25:00Z", "updated_at": "2026-08-07T00:25:00Z" }, { "event_id": "HIT-INS-033", "title": "冷冻学会成立", "date_start": "1976-04-04", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "Michigan / North America / Global", "path_family": "suspension", "event_type": "institution", "claim": "Robert Ettinger 于 1976 年 4 月 4 日在底特律成立 Cryonics Institute，把《永生的前景》中的人体验存设想转成长期运营机构。", "summary": "冷冻学会把艾廷格的个人提议转化为持续提供冷冻保存服务的组织。", "sources": [ "SRC-241" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "保存技术仍无法证明复活，机构运营不等于可行医学路径。", "cross_links": [ "HIT-PRA-007", "HIT-INS-032" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:25:00Z", "updated_at": "2026-08-07T00:25:00Z" }, { "event_id": "HIT-INS-034", "title": "脑保存基金会成立", "date_start": "2010-08-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "suspension", "event_type": "institution", "claim": "脑保存基金会于 2010 年 8 月 27 日成立，通过奖项激励长期保存脑连接组，并把“为未来意识上传保存大脑”转化为可竞赛的技术目标。", "summary": "该基金会为脑保存研究建立了奖励、评审和可公开验证的基础设施。", "sources": [ "SRC-242" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "奖项验证保存效果，不证明记忆恢复或意识重建可行。", "cross_links": [ "HIT-TEC-012", "HIT-TEC-016", "HIT-THT-053" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:25:00Z", "updated_at": "2026-08-07T00:25:00Z" }, { "event_id": "HIT-INS-035", "title": "KrioRus 成立", "date_start": "2005", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Russia", "region": "Russia / Europe / Global", "path_family": "suspension", "event_type": "institution", "claim": "俄罗斯超人类主义运动于 2005 年成立 KrioRus，成为首个非美国主体的人体验存服务商，并在 2006 年建成自有低温储存设施。", "summary": "KrioRus 使体验存从美国亚文化扩展为跨国家的基础设施和服务市场。", "sources": [ "SRC-243" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "成立年份存在 2005 年创立与 2006 年设施建成差异，本文按 2005 年记录。", "cross_links": [ "HIT-INS-032", "HIT-INS-033" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T00:25:00Z", "updated_at": "2026-08-07T00:25:00Z" }, { "event_id": "HIT-INS-036", "title": "Nectome 把脑保存服务带入公开争议", "date_start": "2018", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "suspension", "event_type": "institution", "claim": "2018 年，获 Y Combinator 支持的 Nectome 提出用醛稳定低温保存连接大脑的服务，声称过程“100% 致命”，引发关于同意、死亡定义和意识上传伦理的公开争议。", "summary": "Nectome 把脑保存从科学奖赛推进为面向临终者、涉及生命终结政策的商业提案。", "sources": [ "SRC-244" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "该服务未证明可行，公司表述与监管状态需持续核验。", "cross_links": [ "HIT-TEC-012", "HIT-TEC-016", "HIT-THT-053" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia Mind uploading 词条核验。", "created_at": "2026-08-07T00:25:00Z", "updated_at": "2026-08-07T00:25:00Z" }, { "event_id": "HIT-DEM-005", "title": "奥尔尚斯基发表《寻找玛土撒拉》", "date_start": "1990-11-02", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "United States / Global", "path_family": "maintenance", "event_type": "demographic", "claim": "Olshansky 等人在 1990 年 Science 发表《寻找玛土撒拉》，估计人类寿命可能存在上限，开启现代寿命极限辩论。", "summary": "该文让“人类寿命是否有硬上限”成为人口学和老年科学的公开争论。", "sources": [ "SRC-245" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "上限估计依赖历史数据和假设，后续极限寿命数据不断挑战该结论。", "cross_links": [ "HIT-DEM-001", "HIT-DEM-002", "HIT-DEM-006" ], "chapter": "人口统计、死亡率与健康寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref 核验。", "created_at": "2026-08-07T00:30:00Z", "updated_at": "2026-08-07T00:30:00Z" }, { "event_id": "HIT-DEM-006", "title": "奥彭与沃佩尔发表《打破寿命预期上限》", "date_start": "2002-05-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Denmark / Germany / Global", "region": "Europe / Global", "path_family": "maintenance", "event_type": "demographic", "claim": "Oeppen 与 Vaupel 在 2002 年 Science 发表《Broken Limits to Life Expectancy》，用最纪录寿命持续上升证据质疑固定寿命上限。", "summary": "该文把寿命极限问题从静态上限转向趋势和异质性研究。", "sources": [ "SRC-246" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "趋势外推不等于无限寿命，极端寿命记录仍需严格验证。", "cross_links": [ "HIT-DEM-001", "HIT-DEM-005", "HIT-SCI-013" ], "chapter": "人口统计、死亡率与健康寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref 核验。", "created_at": "2026-08-07T00:30:00Z", "updated_at": "2026-08-07T00:30:00Z" }, { "event_id": "HIT-THT-069", "title": "沃佩尔发表《人类衰老的人口生物学》", "date_start": "2010-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Denmark / Germany / Global", "region": "Europe / Global", "path_family": "maintenance", "event_type": "thought", "claim": "Vaupel 在 2010 年 Nature 发表《Biodemography of human ageing》，主张衰老并非不可改变，人口学与生物学应共同解释死亡率变化。", "summary": "该综述为“衰老可被干预”提供人口学证据框架。", "sources": [ "SRC-247" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "可塑性不等于无限延寿，干预效果仍需因果验证。", "cross_links": [ "HIT-DEM-001", "HIT-DEM-006", "HIT-SCI-013" ], "chapter": "人口统计、死亡率与健康寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref 核验。", "created_at": "2026-08-07T00:30:00Z", "updated_at": "2026-08-07T00:30:00Z" }, { "event_id": "HIT-SCI-040", "title": "董等人发表《人类寿命存在极限的证据》", "date_start": "2016-10-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "maintenance", "event_type": "demographic", "claim": "Dong 等人在 2016 年 Nature 发表论文，基于国际长寿数据库主张人类最长寿命在 1990 年代后期达到平台期，重新提出寿命上限。", "summary": "该文重新点燃寿命极限争论，并催生后续统计质疑和更长寿命证据。", "sources": [ "SRC-248" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "数据质量、记录验证和统计方法均受到质疑，平台期结论并非定论。", "cross_links": [ "HIT-DEM-005", "HIT-DEM-006", "HIT-DEM-002" ], "chapter": "人口统计、死亡率与健康寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref 核验。", "created_at": "2026-08-07T00:30:00Z", "updated_at": "2026-08-07T00:30:00Z" }, { "event_id": "HIT-SCI-041", "title": "FOXO3A 与人类长寿关联发表", "date_start": "2008-09-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Japan", "region": "United States / Japan / Global", "path_family": "maintenance", "event_type": "technology", "claim": "Willcox 等人在 2008 年 PNAS 发表研究，证明 FOXO3A 基因型与日本裔美国男性长寿显著相关，为人类长寿遗传提供可复制候选位点。", "summary": "FOXO3A 成为人类长寿遗传研究中被反复检验的代表性基因。", "sources": [ "SRC-249" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "遗传关联在不同人群中的效应和因果机制仍需独立复核。", "cross_links": [ "HIT-THT-055", "HIT-SCI-009", "HIT-SCI-019" ], "chapter": "老年学、进化论与细胞寿命", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref 核验。", "created_at": "2026-08-07T00:30:00Z", "updated_at": "2026-08-07T00:30:00Z" }, { "event_id": "HIT-LIT-020", "title": "雪莱出版《弗兰肯斯坦》", "date_start": "1818-01-01", "date_type": "exact", "period_id": "period-19th-century", "civilization": "United Kingdom", "region": "Europe / Global", "path_family": "reconstruction", "event_type": "literature", "claim": "1818 年 1 月 1 日，玛丽·雪莱匿名出版《弗兰肯斯坦》，讲述用死者组织拼接并赋予生命的造物，提出人造生命是否拥有身份、记忆、道德地位以及创造者责任的问题。", "summary": "《弗兰肯斯坦》把复活与生命再造从神话转写为现代科学小说的核心母题。", "sources": [ "SRC-250" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "作品是虚构叙事，不构成人造生命或复活技术的可行性证据。", "cross_links": [ "HIT-LIT-004", "HIT-THT-042", "HIT-LIT-021" ], "chapter": "神话、死亡意识与身份连续性", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T01:00:00Z", "updated_at": "2026-08-07T01:00:00Z" }, { "event_id": "HIT-LIT-021", "title": "威尔斯出版《时间机器》", "date_start": "1895-05-07", "date_type": "exact", "period_id": "period-19th-century", "civilization": "United Kingdom", "region": "Europe / Global", "path_family": "philosophical", "event_type": "literature", "claim": "1895 年 5 月 7 日，赫伯特·乔治·威尔斯出版《时间机器》，让主人公进入遥远未来，观察人类退化、物种更替与地球末日，把人类文明视为时间尺度上的短暂阶段。", "summary": "《时间机器》使未来等待、物种灭绝与文明长期演化成为可叙述的科学幻想对象。", "sources": [ "SRC-251" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "作品是虚构叙事，时间旅行和未来观察不构成物理或工程承诺。", "cross_links": [ "HIT-LIT-020", "HIT-LIT-022", "HIT-THT-044" ], "chapter": "神话、死亡意识与身份连续性", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T01:00:00Z", "updated_at": "2026-08-07T01:00:00Z" }, { "event_id": "HIT-LIT-022", "title": "迪克出版《仿生人会梦见电子羊吗？》", "date_start": "1968", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "philosophical", "event_type": "literature", "claim": "1968 年，菲利普·迪克出版《仿生人会梦见电子羊吗？》，以追捕仿生人的故事追问移情、记忆和道德地位是否能区分人与人工生命。", "summary": "该小说把“谁算人”从生物出身转向行为、情感和记忆测试。", "sources": [ "SRC-252" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "作品是虚构叙事，移情测试不等于现实人格判据。", "cross_links": [ "HIT-LIT-011", "HIT-THT-042", "HIT-THT-044" ], "chapter": "神话、死亡意识与身份连续性", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T01:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-LIT-023", "title": "阿西莫夫发表《两百岁的人》", "date_start": "1976-02", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "philosophical", "event_type": "literature", "claim": "1976 年 2 月，艾萨克·阿西莫夫发表《两百岁的人》，写机器人安德鲁通过自由、法律身份、身体改造和最终接受死亡来成为人类。", "summary": "该作品把机械永生与有限、可死亡的人类身份并置，成为机器争取人格的重要叙事。", "sources": [ "SRC-253" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "作品是虚构叙事，机器人人格与死亡选择不构成现实伦理判例。", "cross_links": [ "HIT-LIT-022", "HIT-THT-042", "HIT-THT-044" ], "chapter": "神话、死亡意识与身份连续性", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T01:00:00Z", "updated_at": "2026-08-07T01:00:00Z" }, { "event_id": "HIT-LIT-024", "title": "斯蒂芬森出版《雪崩》", "date_start": "1992-06", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "digital_migration", "event_type": "literature", "claim": "1992 年 6 月，尼尔·斯蒂芬森出版《雪崩》，普及元宇宙、化身、数字身份和语言病毒隐喻，把虚拟空间表现为可承载身份与文明的另一套基础设施。", "summary": "《雪崩》让数字身份和虚拟世界进入大众想象，并为后来的虚拟永生叙事提供基础设施词汇。", "sources": [ "SRC-254" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "作品是虚构叙事，元宇宙和数字身份设定不构成技术路线或可行性证据。", "cross_links": [ "HIT-LIT-011", "HIT-LIT-013", "HIT-THT-044" ], "chapter": "神话、死亡意识与身份连续性", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T01:00:00Z", "updated_at": "2026-08-07T01:00:00Z" }, { "event_id": "HIT-INS-037", "title": "Life Extension Foundation 成立", "date_start": "1980", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "1980 年，Life Extension Foundation 在美国成立，以研究控制衰老和消灭疾病为目标的健康寿命组织；2018 年更名为 Biomedical Research & Longevity Society。", "summary": "该组织把补剂零售、健康寿命研究和长寿公共话语长期绑定，是产业资金网络中的早期常设机构。", "sources": [ "SRC-255" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "组织活动与补剂商业之间的边界需按年度核验，不能把商业宣称视为科学结论。", "cross_links": [ "HIT-INS-030", "HIT-INS-038" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T02:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-038", "title": "Methuselah Mouse Prize 建立", "date_start": "2003", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2003 年前后，Methuselah Foundation 设立 Methuselah Mouse Prize（Mprize），以现金奖励和可验证寿命纪录推动延寿研究，并公开鼓励晚期介入型实验。", "summary": "Mprize 把延寿研究转化为公开竞赛、捐赠和媒体动员基础设施。", "sources": [ "SRC-256" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "奖赛具体规则、奖金规模和各届纪录需按年份继续核验。", "cross_links": [ "HIT-INS-030", "HIT-INS-012" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wayback Machine 存档页核验。", "created_at": "2026-08-07T02:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-039", "title": "Rejuvenate Bio 成立并进入犬类基因治疗试验", "date_start": "2018", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2018 年，乔治·丘奇、丹尼尔·奥利弗与诺亚·戴维森共同成立 Rejuvenate Bio，专注把靶向基因治疗用于衰老相关疾病，并开始以犬类心脏病作为转化路径。", "summary": "Rejuvenate Bio 把动物健康作为长寿基因治疗的监管与商业捷径。", "sources": [ "SRC-257" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "公司成立日期与犬类试验节点需按官方存档继续复核；犬类结果不能外推到人类。", "cross_links": [ "HIT-INS-030", "HIT-TEC-013", "HIT-INS-040" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wayback Machine 官方存档核验。", "created_at": "2026-08-07T02:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-040", "title": "Cambrian Biopharma 与 Novartis 达成 mTOR 抑制剂许可", "date_start": "2022-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States / Switzerland", "region": "North America / Europe / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2022 年 2 月，Cambrian Biopharma 宣布从 Novartis 获得 mTOR 抑制剂项目许可，并设立子公司 Tornado Therapeutics，把衰老相关代谢通路引入临床开发。", "summary": "该交易显示大型药企开始向长寿生物技术公司外放衰老代谢管线。", "sources": [ "SRC-258" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "许可金额、里程碑和后续研发状态需按公司披露持续核验。", "cross_links": [ "HIT-INS-039", "HIT-INS-041", "HIT-TEC-013" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia Novartis 词条交叉核验。", "created_at": "2026-08-07T02:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-041", "title": "Juvena Therapeutics 完成 3350 万美元 B 轮融资", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2026 年 1 月，Juvena Therapeutics 完成由 Bison Ventures 领投的 3350 万美元 B 轮融资，用于推进肌肉与代谢再生的生物药管线。", "summary": "Juvena 的融资显示产业资本继续支持再生生物药和 AI 辅助蛋白发现路线。", "sources": [ "SRC-259" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "融资用途和管线进度以公司披露为准，不构成药物有效结论。", "cross_links": [ "HIT-INS-040", "HIT-TEC-013", "HIT-SCI-017" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做公司官方新闻页核验。", "created_at": "2026-08-07T02:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-042", "title": "长时程增强机制首次被系统发表", "date_start": "1973-07", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United Kingdom / Norway", "region": "Europe / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "1973 年 7 月，Bliss 与 Lømo 发表《Long-lasting potentiation of synaptic transmission...》，证明突触连接可因近期活动而长期增强，为记忆可塑性和记忆编辑研究提供核心机制基础。", "summary": "LTP 把记忆从不可观察的心灵现象转化为可测量、可干预的突触机制。", "sources": [ "SRC-260" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "LTP 是记忆形成的重要机制之一，但不等于完整记忆内容或身份连续性。", "cross_links": [ "HIT-TEC-007", "HIT-THT-030", "HIT-THT-042" ], "chapter": "神经计算、记忆与数字迁移", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-07T03:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-036", "title": "Mead 提出神经形态电子系统", "date_start": "1990", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "1990 年，Carver Mead 在 Proceedings of the IEEE 发表《Neuromorphic electronic systems》，提出用模拟 VLSI 电路模仿神经系统计算，为脑启发计算确立学科框架。", "summary": "该文把“像脑一样计算的硬件”从比喻变为可工程实现的学科方向。", "sources": [ "SRC-261" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "神经形态硬件是脑启发计算，不构成大脑意识或人格复制证明。", "cross_links": [ "HIT-TEC-037", "HIT-TEC-038", "HIT-THT-053" ], "chapter": "神经计算、记忆与数字迁移", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。；日期补齐：Crossref 1990 (published-print, year, v3)", "created_at": "2026-08-07T03:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-037", "title": "IBM 发布 TrueNorth 神经形态芯片", "date_start": "2014", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "digital_migration", "event_type": "technology", "claim": "2014 年，IBM 发布 TrueNorth 神经形态芯片，包含超过 100 万个可编程神经元和 2.68 亿个突触，以低功耗事件驱动方式模拟脑式计算。", "summary": "TrueNorth 把大规模神经形态计算从实验芯片推进到生产规模架构。", "sources": [ "SRC-262" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "芯片规模不等于全脑仿真能力，TrueNorth 架构后来也被更高效研究芯片取代。", "cross_links": [ "HIT-TEC-036", "HIT-TEC-038", "HIT-THT-053" ], "chapter": "神经计算、记忆与数字迁移", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia Cognitive computer 词条核验。", "created_at": "2026-08-07T03:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-038", "title": "Intel 发布 Loihi 神经形态研究芯片", "date_start": "2017", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2017 年，Intel 发布 Loihi 神经形态研究芯片，支持异步脉冲神经网络和片上学习，为脑启发硬件进入产业研究提供平台。", "summary": "Loihi 把在线学习和低功耗脉冲计算带入大型芯片厂商的长期研究议程。", "sources": [ "SRC-263" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "Loihi 是研究芯片，不是通用大脑仿真或人体增强产品。", "cross_links": [ "HIT-TEC-036", "HIT-TEC-037", "HIT-TEC-039" ], "chapter": "神经计算、记忆与数字迁移", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia Neuromorphic computing 词条核验。", "created_at": "2026-08-07T03:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-039", "title": "SpiNNaker 达到百万核里程碑", "date_start": "2018-10-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Europe", "region": "Europe / Global", "path_family": "digital_migration", "event_type": "technology", "claim": "2018 年 10 月 14 日，人类脑计划宣布 SpiNNaker 达到百万核里程碑；该系统以 57,600 个节点、超过 100 万个处理器核模拟大规模脉冲神经网络。", "summary": "SpiNNaker 为大规模实时脉冲神经网络模拟提供了可运行的并行计算基础设施。", "sources": [ "SRC-264" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "百万核模拟规模不等于完整人脑仿真，也不支持意识上传可行性结论。", "cross_links": [ "HIT-INS-026", "HIT-TEC-037", "HIT-TEC-038" ], "chapter": "神经计算、记忆与数字迁移", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia SpiNNaker 词条核验。", "created_at": "2026-08-07T03:00:00Z", "updated_at": "2026-08-07T03:00:00Z" }, { "event_id": "HIT-POL-010", "title": "OECD 通过人工智能原则", "date_start": "2019-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "OECD member states", "region": "Global", "path_family": "cross_path", "event_type": "policy", "claim": "2019 年 5 月，OECD 成员国通过《人工智能建议书》，提出以人为本、透明、稳健安全、问责等原则，成为首个由政府签署的 AI 原则。", "summary": "OECD AI 原则为后续国家级 AI 战略和风险治理提供了共同语言。", "sources": [ "SRC-265" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "原则是软法标准，不直接约束企业或替代具体监管。", "cross_links": [ "HIT-POL-005", "HIT-POL-009", "HIT-POL-011" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 OECD 官方页 Wayback Machine 存档核验。", "created_at": "2026-08-07T04:00:00Z", "updated_at": "2026-08-07T04:00:00Z" }, { "event_id": "HIT-POL-011", "title": "WHO 发布 AI 健康伦理与治理指南", "date_start": "2021-06-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "World Health Organization", "region": "Global", "path_family": "cross_path", "event_type": "policy", "claim": "2021 年 6 月 28 日，WHO 发布首份面向健康领域的 AI 伦理与治理指南，提出以人为本、数据保护、透明、问责和公平等六项原则。", "summary": "WHO 指南把 AI 健康应用纳入全球公共卫生治理框架。", "sources": [ "SRC-266" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "指南是规范建议，不替代各国药品和器械监管。", "cross_links": [ "HIT-POL-001", "HIT-POL-004", "HIT-POL-012" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 WHO 官方出版物页核验。", "created_at": "2026-08-07T04:00:00Z", "updated_at": "2026-08-07T04:00:00Z" }, { "event_id": "HIT-POL-012", "title": "UNESCO 通过首份全球 AI 伦理建议书", "date_start": "2021-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "UNESCO member states", "region": "Global", "path_family": "cross_path", "event_type": "policy", "claim": "2021 年 11 月，UNESCO 193 个成员国通过首份全球 AI 伦理建议书，要求 AI 尊重人权、人的尊严，并接受人类监督。", "summary": "UNESCO 建议书把 AI 伦理从行业准则提升为全球标准设置议题。", "sources": [ "SRC-267" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "建议书为非约束性标准，各国落实程度差异较大。", "cross_links": [ "HIT-POL-010", "HIT-POL-013", "HIT-POL-005" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 UNESCO 官方页面核验。", "created_at": "2026-08-07T04:00:00Z", "updated_at": "2026-08-07T04:00:00Z" }, { "event_id": "HIT-POL-013", "title": "AI 安全峰会发布《布莱切利宣言》", "date_start": "2023-11-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / International", "region": "Global", "path_family": "cross_path", "event_type": "policy", "claim": "2023 年 11 月 1 日至 2 日，英国 AI 安全峰会发布《布莱切利宣言》，与会国家同意共同识别和治理前沿 AI 带来的安全风险。", "summary": "《布莱切利宣言》把前沿 AI 安全列为多国高层政治议题。", "sources": [ "SRC-268" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "宣言强调共同认知和后续会议机制，本身不是具有约束力的条约。", "cross_links": [ "HIT-POL-006", "HIT-POL-014", "HIT-THT-045" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 GOV.UK 官方页面核验。", "created_at": "2026-08-07T04:00:00Z", "updated_at": "2026-08-07T04:00:00Z" }, { "event_id": "HIT-POL-014", "title": "《人工智能框架公约》开放签署", "date_start": "2024-09-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Council of Europe / International", "region": "Europe / Global", "path_family": "cross_path", "event_type": "policy", "claim": "2024 年 9 月 5 日，《人工智能框架公约》在维尔纽斯开放签署，成为首份具有约束力的国际 AI 条约，要求 AI 治理符合人权、民主和法治。", "summary": "该公约把 AI 风险治理从自愿原则推进到多国条约义务。", "sources": [ "SRC-269" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "条约生效取决于各国批准数量，执行和监督机制仍需后续观察。", "cross_links": [ "HIT-POL-009", "HIT-POL-013", "HIT-POL-005" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 条约词条核验。", "created_at": "2026-08-07T04:00:00Z", "updated_at": "2026-08-07T04:00:00Z" }, { "event_id": "HIT-SCI-043", "title": "人类体细胞化学重编程为多能干细胞", "date_start": "2022-04-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China / Global", "region": "Asia / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2022 年 4 月 13 日，Guan 等人在 Nature 报告用化学小分子组合将人类体细胞重编程为多能干细胞，提示细胞身份重置可能不依赖外源转录因子。", "summary": "化学重编程为更接近传统药物的细胞身份重写路线提供基础。", "sources": [ "SRC-270" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "结果为体外细胞研究，效率和体内安全性仍需大量验证。", "cross_links": [ "HIT-SCI-007", "HIT-SCI-028", "HIT-SCI-029", "HIT-TEC-013" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T05:00:00Z", "updated_at": "2026-08-07T05:00:00Z" }, { "event_id": "HIT-SCI-044", "title": "部分化学重编程显示细胞年轻化证据", "date_start": "2024-03-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Global", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2024 年 3 月 22 日，eLife 发表多组学研究表明，部分化学重编程可降低小鼠成纤维细胞生物年龄指标，并伴随线粒体氧化磷酸化等功能变化。", "summary": "部分化学重编程提示细胞年轻化可能在不完全去分化时发生。", "sources": [ "SRC-271" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "研究主要基于体外细胞和部分体内证据，毒性与效率仍需进一步验证。", "cross_links": [ "HIT-SCI-043", "HIT-SCI-029", "HIT-SCI-011" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T05:00:00Z", "updated_at": "2026-08-07T05:00:00Z" }, { "event_id": "HIT-SCI-045", "title": "表观遗传编辑临床转化框架综述发表", "date_start": "2025-11-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Global", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2025 年 11 月 24 日，Nature Reviews Drug Discovery 发表《Epigenetic editing: from concept to clinic》，系统讨论不改 DNA 序列、通过改写表观遗传标记重编程基因表达的治疗路线。", "summary": "该综述把表观遗传编辑从概念推进到临床转化框架和监管讨论。", "sources": [ "SRC-272" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "综述汇总早期临床前和临床方向，不证明全身逆龄或广泛抗衰疗效。", "cross_links": [ "HIT-SCI-009", "HIT-SCI-046", "HIT-SCI-043" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T05:00:00Z", "updated_at": "2026-08-07T05:00:00Z" }, { "event_id": "HIT-SCI-046", "title": "体内 hit-and-run 表观遗传沉默 PCSK9", "date_start": "2024-03-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "North America / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2024 年 3 月 14 日，Nature 发表研究，展示体内 hit-and-run 式表观遗传编辑可持久沉默 PCSK9，为不改变 DNA 序列的体内表观遗传疗法提供证据。", "summary": "该研究把表观遗传编辑从体外工具推进到体内持久基因沉默。", "sources": [ "SRC-273" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "研究针对特定靶点，不等同于全身重编程或抗衰治疗。", "cross_links": [ "HIT-SCI-045", "HIT-SCI-009", "HIT-SCI-043" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T05:00:00Z", "updated_at": "2026-08-07T05:00:00Z" }, { "event_id": "HIT-SCI-047", "title": "记忆痕迹细胞部分重编程恢复小鼠认知", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "North America / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 3 月，Neuron 发表研究表明，在衰老和阿尔茨海默病模型小鼠的记忆痕迹细胞中进行 OSK 介导的部分重编程，可改善分子特征并恢复学习记忆能力。", "summary": "该研究把部分重编程从组织修复推进到记忆网络层面的认知恢复。", "sources": [ "SRC-274" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "结果基于小鼠模型，神经网络、身份和安全性风险仍需人体验证。", "cross_links": [ "HIT-TEC-007", "HIT-SCI-011", "HIT-SCI-044" ], "chapter": "神经计算、记忆与数字迁移", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-07T05:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-SCI-048", "title": "DunedinPoAm 衰老速度血检算法发表", "date_start": "2020-05-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "New Zealand / United States", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "2020 年 5 月 5 日，Belsky 等人在 eLife 发表 DunedinPoAm 算法，用血液 DNA 甲基化测量个体衰老速度，为后续 DunedinPACE 提供前身。", "summary": "DunedinPoAm 把“衰老速度”从群体统计转化为可测的个体分子指标。", "sources": [ "SRC-275" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "算法是预测关联工具，改变指标不必然等于改变健康结局。", "cross_links": [ "HIT-SCI-019", "HIT-SCI-035", "HIT-SCI-036" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T06:00:00Z", "updated_at": "2026-08-07T06:00:00Z" }, { "event_id": "HIT-SCI-049", "title": "GrimAge 2 发表", "date_start": "2022-12-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "2022 年 12 月 14 日，Aging 发表 DNA 甲基化 GrimAge version 2，把寿命和健康寿命预测扩展到更大范围的甲基化标记。", "summary": "GrimAge 2 是 GrimAge 家族的后续版本，用于延长寿命与健康寿命的分子风险估计。", "sources": [ "SRC-276" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该版本仍需跨人群验证，不能单独作为个体医疗决策依据。", "cross_links": [ "HIT-SCI-036", "HIT-SCI-019", "HIT-SCI-023" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T06:00:00Z", "updated_at": "2026-08-07T06:00:00Z" }, { "event_id": "HIT-SCI-050", "title": "Aging Biomarker Consortium 发布脑衰老标志物框架", "date_start": "2023-05-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China / Global", "region": "Asia / Global", "path_family": "maintenance", "event_type": "technology", "claim": "2023 年 5 月 6 日，Aging Biomarker Consortium 发表脑衰老生物标志物共识框架，试图把分子、影像、功能和认知指标纳入统一标准。", "summary": "脑衰老标志物框架为认知衰老的测量、干预和监管沟通提供结构化基础。", "sources": [ "SRC-277" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "共识框架仍需跨人群验证和临床终点关联。", "cross_links": [ "HIT-SCI-023", "HIT-SCI-051", "HIT-SCI-052" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T06:00:00Z", "updated_at": "2026-08-07T06:00:00Z" }, { "event_id": "HIT-SCI-051", "title": "Aging Biomarker Consortium 发布血管衰老标志物框架", "date_start": "2023-08-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China / Global", "region": "Asia / Global", "path_family": "maintenance", "event_type": "technology", "claim": "2023 年 8 月 1 日，Aging Biomarker Consortium 发表血管衰老生物标志物共识框架，覆盖内皮、动脉硬化、影像和分子指标。", "summary": "血管衰老标志物框架把循环系统老化从单点指标扩展为多模态测量体系。", "sources": [ "SRC-278" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "框架是研究共识，不等同于监管批准的诊断终点。", "cross_links": [ "HIT-SCI-023", "HIT-SCI-050", "HIT-SCI-052" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T06:00:00Z", "updated_at": "2026-08-07T06:00:00Z" }, { "event_id": "HIT-SCI-052", "title": "Aging Biomarker Consortium 发布心脏衰老标志物框架", "date_start": "2023-09-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China / Global", "region": "Asia / Global", "path_family": "maintenance", "event_type": "technology", "claim": "2023 年 9 月 27 日，Aging Biomarker Consortium 发表心脏衰老生物标志物共识框架，把心脏结构、功能、分子与临床终点组织为可验证体系。", "summary": "心脏衰老标志物框架为心血管老化研究提供器官级统一语言。", "sources": [ "SRC-279" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "共识框架仍需独立验证，不能直接用于个体化用药建议。", "cross_links": [ "HIT-SCI-023", "HIT-SCI-050", "HIT-SCI-051" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T06:00:00Z", "updated_at": "2026-08-07T06:00:00Z" }, { "event_id": "HIT-THT-071", "title": "国际脑计划神经伦理问题指南发表", "date_start": "2018-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "2018 年 10 月，Neuron 发表《Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives》，提出隐私、主体性、责任和公平等神经伦理问题框架。", "summary": "该文为国际脑计划的伦理审查提供共享问题清单。", "sources": [ "SRC-280" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "指南是研究伦理共识，不构成法律约束。", "cross_links": [ "HIT-INS-023", "HIT-THT-026", "HIT-POL-015" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。；日期补齐：Crossref 2018-10 (published-print, month, v3)", "created_at": "2026-08-07T07:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-INS-042", "title": "Neurorights Initiative 进入国际议程", "date_start": "2019", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States / International", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "2019 年起，Rafael Yuste 担任 NeuroRights Initiative 主任，并与人权律师 Jared Gesner 联合创办 Neurorights Foundation，推动把神经权利纳入人权框架。", "summary": "Neurorights Initiative 把心理隐私、能动性、身份和认知自由组织为神经权利议程。", "sources": [ "SRC-281" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "机构成立和基金会创办年份需按官方记录进一步核验。", "cross_links": [ "HIT-THT-071", "HIT-POL-015", "HIT-POL-016" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T07:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-POL-015", "title": "OECD 发布负责任神经技术创新建议", "date_start": "2019-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "OECD member states", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "2019 年 12 月，OECD 确认负责任神经技术创新的原则和建议，把认知自由、心理健康、公平、隐私和风险治理纳入神经技术政策。", "summary": "OECD 建议为神经技术从研究到应用的治理提供了首个政府间标准框架。", "sources": [ "SRC-282" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "建议是软法框架，各国落实程度仍需观察。", "cross_links": [ "HIT-INS-042", "HIT-POL-016", "HIT-THT-071" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia Neuroethics 词条交叉核验。", "created_at": "2026-08-07T07:00:00Z", "updated_at": "2026-08-07T07:00:00Z" }, { "event_id": "HIT-POL-016", "title": "智利提出神经权利法案", "date_start": "2020-10-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Chile", "region": "Latin America", "path_family": "social_composite", "event_type": "policy", "claim": "2020 年 10 月 7 日，智利参议员 Girardi 与 Rafael Yuste 等提出两项神经权利法案，一项修宪保障心理隐私，另一项保护人的身心完整性。", "summary": "智利法案把神经权利从学术概念推进到国家宪法和法律议程。", "sources": [ "SRC-283" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "法案提出不等于通过，后续立法和司法解释需持续核验。", "cross_links": [ "HIT-INS-042", "HIT-POL-015", "HIT-THT-072" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T07:00:00Z", "updated_at": "2026-08-07T07:00:00Z" }, { "event_id": "HIT-THT-072", "title": "神经权利作为重构人权框架发表", "date_start": "2023-12-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "2023 年 12 月 15 日，Frontiers in Political Science 发表《Neurorights as reconceptualized human rights》，系统论证神经权利是把既有人权重新概念化以应对脑数据、自由意志和身份连续风险。", "summary": "该框架把神经权利从口号转化为可争论、可制度化的权利理论。", "sources": [ "SRC-284" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "论文是学术框架，不代表各国已统一采纳该权利分类。", "cross_links": [ "HIT-POL-016", "HIT-THT-042", "HIT-POL-015" ], "chapter": "失败教训、监管边界与反证", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T07:00:00Z", "updated_at": "2026-08-07T07:00:00Z" }, { "event_id": "HIT-TEC-040", "title": "Facebook 建立纪念账户机制", "date_start": "2009", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "digital_migration", "event_type": "technology", "claim": "2009 年，Facebook 更新政策，允许将去世用户账户转为纪念状态，把数字身份保留制度化。", "summary": "纪念账户机制使社交平台成为死亡、哀悼和数字遗产基础设施。", "sources": [ "SRC-285" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "平台政策和纪念账户管理方式随后多次调整。", "cross_links": [ "HIT-THT-025", "HIT-TEC-041", "HIT-POL-017" ], "chapter": "数字迁移、身份连续与数字遗产", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia Online mourning 词条核验。", "created_at": "2026-08-07T08:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-041", "title": "Google 推出 Inactive Account Manager", "date_start": "2013-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "digital_migration", "event_type": "technology", "claim": "2013 年 4 月，Google 推出 Inactive Account Manager，允许用户指定账户数据在长期不活跃后分享给可信联系人，成为主流平台死亡数据处理工具。", "summary": "该工具把数字遗产从法律问题扩展为平台默认的用户控制功能。", "sources": [ "SRC-286" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "具体发布日与后续策略调整需按 Google 官方公告继续核验。", "cross_links": [ "HIT-TEC-040", "HIT-POL-017", "HIT-THT-073" ], "chapter": "数字迁移、身份连续与数字遗产", "notes": "draft，等待来源语境复核。本轮已做 Google 官方帮助页核验。", "created_at": "2026-08-07T08:00:00Z", "updated_at": "2026-08-07T08:00:00Z" }, { "event_id": "HIT-POL-017", "title": "美国统一法律委员会提出数字资产访问法", "date_start": "2014-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America", "path_family": "social_composite", "event_type": "policy", "claim": "2014 年 7 月，美国统一法律委员会提出《统一数字资产受托人访问法》（UFADAA），为死者数字资产访问建立法律框架。", "summary": "UFADAA 是数字遗产从平台政策进入统一州法议程的关键节点。", "sources": [ "SRC-287" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "该法后续被修订为 RUFADAA，各州采纳进度差异较大。", "cross_links": [ "HIT-TEC-040", "HIT-TEC-041", "HIT-THT-073" ], "chapter": "数字迁移、身份连续与数字遗产", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia Post-mortem privacy 词条核验。", "created_at": "2026-08-07T08:00:00Z", "updated_at": "2026-08-07T08:00:00Z" }, { "event_id": "HIT-THT-073", "title": "《Digital Afterlife》把数字来世建为跨学科对象", "date_start": "2020-03-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Global", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "2020 年 3 月 11 日，Savin-Baden 与 Mason 出版《Digital Afterlife》，把数字永生、数字化身、数字遗产产业作为跨学科研究对象。", "summary": "该书把数字来世从流行叙事提升为死亡研究、技术与伦理交叉领域。", "sources": [ "SRC-288" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该书是研究综述和框架，不证明数字意识延续或数字永生可行。", "cross_links": [ "HIT-THT-025", "HIT-TEC-040", "HIT-THT-074" ], "chapter": "数字迁移、身份连续与数字遗产", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T08:00:00Z", "updated_at": "2026-08-07T08:00:00Z" }, { "event_id": "HIT-THT-074", "title": "数字来世进入死亡研究议程", "date_start": "2021-07-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "2021 年 7 月 30 日，Mortality 发表《Digital afterlife: death matters in a digital age》，把数字来世、数字化身和死后在线身份纳入死亡研究议程。", "summary": "该文推动数字死亡从边缘话题进入主流死亡研究学术讨论。", "sources": [ "SRC-289" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "文章是研究议程，不代表数字身份或数字来世已获法律或技术承认。", "cross_links": [ "HIT-THT-073", "HIT-THT-025", "HIT-POL-017" ], "chapter": "数字迁移、身份连续与数字遗产", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T08:00:00Z", "updated_at": "2026-08-07T08:00:00Z" }, { "event_id": "HIT-THT-075", "title": "巴特勒批评洛克记忆判准", "date_start": "1736", "date_type": "approx", "period_id": "period-early-modern-europe", "civilization": "United Kingdom", "region": "Europe", "path_family": "philosophical", "event_type": "thought", "claim": "1736 年，约瑟夫·巴特勒在《宗教的类比》中批评洛克把人格同一性建立在记忆之上，认为人格同一性应预设而非由记忆构成。", "summary": "巴特勒的反记忆判准成为后来心理连续性理论的经典起点。", "sources": [ "SRC-290" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "文本年代与版本较多，本事件以首次出版年份记录。", "cross_links": [ "HIT-THT-030", "HIT-THT-076", "HIT-THT-042" ], "chapter": "神话、死亡意识与身份连续性", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 文本核验。", "created_at": "2026-08-07T09:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-076", "title": "里德提出勇敢军官反例", "date_start": "1785", "date_type": "approx", "period_id": "period-early-modern-europe", "civilization": "United Kingdom", "region": "Europe", "path_family": "philosophical", "event_type": "thought", "claim": "1785 年，托马斯·里德在《人类理智能力论》中提出勇敢军官反例，指出记忆判准会破坏人格同一性的传递性。", "summary": "里德的反例成为人格同一性理论必须处理的核心逻辑难题。", "sources": [ "SRC-291" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "文本版本和解释细节较多，本事件记录思想史节点而非唯一判准。", "cross_links": [ "HIT-THT-030", "HIT-THT-075", "HIT-THT-077" ], "chapter": "神话、死亡意识与身份连续性", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 文本核验。", "created_at": "2026-08-07T09:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-077", "title": "威廉斯提出自我与未来问题", "date_start": "1970", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United Kingdom", "region": "Europe / Global", "path_family": "philosophical", "event_type": "thought", "claim": "1970 年，伯纳德·威廉斯在《The Self and the Future》中用身体与心理换位思想实验讨论人格同一性，质疑心理连续性直觉的稳定性。", "summary": "威廉斯把身体、心理与未来选择纳入同一性问题，为后续上传与替换争论提供哲学工具。", "sources": [ "SRC-292" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该文是哲学思想实验，不构成意识上传或人格连续性的技术证明。", "cross_links": [ "HIT-THT-030", "HIT-THT-042", "HIT-THT-078" ], "chapter": "神话、死亡意识与身份连续性", "notes": "draft，等待来源语境复核。本轮已做 SEP Personal Identity 词条交叉核验。", "created_at": "2026-08-07T09:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-078", "title": "舒梅克与斯温伯恩出版《人格同一性》", "date_start": "1984", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United Kingdom / United States", "region": "Europe / North America / Global", "path_family": "philosophical", "event_type": "thought", "claim": "1984 年，悉尼·舒梅克与理查德·斯温伯恩出版《人格同一性》，以功能主义连续性与非还原论人格观展开正面争论。", "summary": "该辩论把人格同一性从定义问题推进到物理主义与非物理主义的核心冲突。", "sources": [ "SRC-293" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "书中论证属于哲学争论，不提供数字复制或意识上传的工程方案。", "cross_links": [ "HIT-THT-042", "HIT-THT-077", "HIT-THT-079" ], "chapter": "神话、死亡意识与身份连续性", "notes": "draft，等待来源语境复核。本轮已做 Internet Archive 文本核验。", "created_at": "2026-08-07T09:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-079", "title": "谢赫特曼提出自我的构成理论", "date_start": "2007-01-01", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "philosophical", "event_type": "thought", "claim": "1996 年，玛丽亚·谢赫特曼出版《The Constitution of Selves》，提出人格同一性不独立于叙事与实践，而是由个人叙述和人际行动构成。", "summary": "构成理论把人格同一性从记忆和心理连续性扩展到叙事、实践和主体行动。", "sources": [ "SRC-294" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该书是哲学理论，不提供数字自我或记忆外化的经验证明。", "cross_links": [ "HIT-THT-030", "HIT-THT-042", "HIT-THT-078" ], "chapter": "神话、死亡意识与身份连续性", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验。；日期补齐：Crossref 2007-01-01 (published-print, day, v3)", "created_at": "2026-08-07T09:00:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-080", "title": "Mollaret 与 Goulon 提出 coma dépassé 概念", "date_start": "1959-07", "date_type": "approx", "period_id": "period-20th-century", "civilization": "France", "region": "Europe / Global", "path_family": "cross_path", "event_type": "thought", "claim": "1959 年 7 月，法国神经学家 Pierre Mollaret 与 Maurice Goulon 在《Revue Neurologique》发表《Le coma dépassé（mémoire préliminaire）》，用“超越昏迷”指称在人工呼吸支持下仍不可逆地丧失脑功能的状态，把死亡判定问题从心肺停止推进到神经功能层面。", "summary": "coma dépassé 是脑死亡概念的早期医学表达，为后续死亡标准化奠定概念基础。", "sources": [ "SRC-295" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "该概念是医学史节点，不等同于现代全球统一的脑死亡标准；各国对判定标准和时机仍有差异。", "cross_links": [ "HIT-SCI-053", "HIT-POL-018" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-07T09:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-053", "title": "哈佛医学院发布不可逆昏迷定义", "date_start": "1968-08-05", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "cross_path", "event_type": "technology", "claim": "1968 年 8 月 5 日，哈佛医学院脑死亡定义特别委员会在 JAMA 发表《A Definition of Irreversible Coma》，提出不可逆昏迷的临床判定标准，成为现代脑死亡标准的奠基性文件。", "summary": "哈佛标准把死亡判定从循环呼吸停止扩展到全脑功能不可逆丧失，重塑了死亡与生命支持制度。", "sources": [ "SRC-296" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "哈佛标准开启脑死亡制度化，但“不可逆昏迷”不等同于对意识、人格或死亡哲学问题的最终裁决。", "cross_links": [ "HIT-THT-080", "HIT-POL-018" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据核验；出版方页面可能因反爬限制返回 403，但 DOI 已解析。", "created_at": "2026-08-07T09:00:00Z", "updated_at": "2026-08-07T09:00:00Z" }, { "event_id": "HIT-POL-018", "title": "美国通过《统一死亡判定法》", "date_start": "1981", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America", "path_family": "cross_path", "event_type": "policy", "claim": "1981 年，美国全国统一州法委员会等机构批准《统一死亡判定法》（UDDA），把循环和呼吸功能不可逆停止或全脑包括脑干功能不可逆停止规定为死亡，为美国脑死亡立法提供统一模板。", "summary": "UDDA 把脑死亡写入示范法，使生命支持制度、器官捐献和死亡宣告具有统一的美国法律框架。", "sources": [ "SRC-297" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "UDDA 是示范法，各州采纳和实施细节不同；该事件不证明法律与医学标准在所有国家统一。", "cross_links": [ "HIT-SCI-053", "HIT-SCI-055" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 Uniform Law Commission 官方页面与 Wikipedia 交叉核验。", "created_at": "2026-08-07T09:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-054", "title": "美国神经病学学会更新成人脑死亡判定指南", "date_start": "2010-06-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "cross_path", "event_type": "technology", "claim": "2010 年 6 月 8 日，美国神经病学学会在 Neurology 发布成人脑死亡判定指南更新，系统化临床检查、辅助测试和判定标准。", "summary": "该指南更新把成人脑死亡判定从临床惯例推进为更明确、可操作的标准。", "sources": [ "SRC-298" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "指南更新是专家共识，后续仍有儿科指南和国际共识迭代；不是人格连续性或意识理论证明。", "cross_links": [ "HIT-SCI-053", "HIT-SCI-055" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T09:00:00Z", "updated_at": "2026-08-07T09:00:00Z" }, { "event_id": "HIT-SCI-055", "title": "World Brain Death Project 发布脑死亡国际共识", "date_start": "2020-09-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "technology", "claim": "2020 年 9 月 15 日，World Brain Death Project 在 JAMA 发布《Determination of Brain Death/Death by Neurologic Criteria》，提出成人与儿童脑死亡/神经学死亡判定的国际最低临床标准。", "summary": "该国际共识尝试减少各国脑死亡判定差异，为生命支持撤除和器官移植提供更一致的临床框架。", "sources": [ "SRC-299" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "国际共识提供最低标准，但各国法律采纳、临床执行和争议案例仍不统一。", "cross_links": [ "HIT-POL-018", "HIT-SCI-054" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T09:00:00Z", "updated_at": "2026-08-07T09:00:00Z" }, { "event_id": "HIT-TEC-042", "title": "铁肺首次用于人体临床救治", "date_start": "1928-10-12", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "Boston / North America / Global", "path_family": "maintenance", "event_type": "technology", "claim": "1928 年 10 月 12 日，美国波士顿儿童医院首次将 Drinker 呼吸机（铁肺）用于一名因脊髓灰质炎呼吸衰竭接近死亡的小女孩，使呼吸衰竭从即刻死亡转化为可长期维持的生命支持问题。", "summary": "铁肺是第一种广泛使用的机械呼吸支持装置，为现代重症监护和生命延续制度奠定技术基础。", "sources": [ "SRC-300" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "铁肺只是维持通气，不修复神经损伤；其长期依赖、感染和设备维护风险显著。", "cross_links": [ "HIT-THT-080", "HIT-TEC-043" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 与 Wikipedia 日期交叉核验。", "created_at": "2026-08-07T10:00:00Z", "updated_at": "2026-08-07T10:00:00Z" }, { "event_id": "HIT-TEC-043", "title": "人工心肺机完成首例成功人体开胸手术", "date_start": "1953-05-06", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "Philadelphia / North America / Global", "path_family": "maintenance", "event_type": "technology", "claim": "1953 年 5 月 6 日，John Gibbon 与 Frank Allbritten 在费城 Thomas Jefferson University Hospital 首次用人工心肺机成功完成人体开胸手术，把心脏手术转化为可暂时接管心肺功能的工程问题。", "summary": "体外循环机器是重症心脏手术和器官移植得以发展的关键生命支持技术。", "sources": [ "SRC-301" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "早期设备风险高，随后的膜式氧合、抗凝和灌注管理才使其成为常规；该事件不代表现代体外循环成熟。", "cross_links": [ "HIT-TEC-042", "HIT-TEC-044" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据与 Wikipedia 日期交叉核验。", "created_at": "2026-08-07T10:00:00Z", "updated_at": "2026-08-07T10:00:00Z" }, { "event_id": "HIT-SCI-056", "title": "闭式胸外心脏按压方法发表", "date_start": "1960-07-09", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "Baltimore / North America / Global", "path_family": "maintenance", "event_type": "technology", "claim": "1960 年 7 月 9 日，Kouwenhoven、Jude 与 Knickerbocker 在 JAMA 发表《Closed-Chest Cardiac Massage》，报道无需开胸的胸外按压复苏方法，成为现代心肺复苏术的基础。", "summary": "闭式胸外按压把心脏骤停后的即刻复苏从开胸操作扩展为可广泛实施的院前生命支持。", "sources": [ "SRC-302" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "该论文描述胸外按压方法，不等于现代 CPR 的全部标准；自主循环恢复与神经预后仍需分层评价。", "cross_links": [ "HIT-THT-080", "HIT-SCI-053" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T10:00:00Z", "updated_at": "2026-08-07T10:00:00Z" }, { "event_id": "HIT-TEC-044", "title": "首例人类心脏移植手术完成", "date_start": "1967-12-03", "date_type": "exact", "period_id": "period-20th-century", "civilization": "South Africa", "region": "Cape Town / Africa / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "1967 年 12 月 3 日，Christiaan Barnard 在南非开普敦 Groote Schuur 医院完成首例人类心脏移植，将 Denise Darvall 的心脏移植给 Louis Washkansky；患者术后清醒，18 天后因肺炎死亡。", "summary": "首例人类心脏移植把终末期器官衰竭从单一生物心脏依赖推进到供体器官替代和免疫抑制管理。", "sources": [ "SRC-303" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "首例患者 18 天后死亡；免疫抑制、供体器官可及性和长期生存问题并未解决。", "cross_links": [ "HIT-TEC-043", "HIT-TEC-045", "HIT-POL-018" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据与 Wikipedia 日期交叉核验。", "created_at": "2026-08-07T10:00:00Z", "updated_at": "2026-08-07T10:00:00Z" }, { "event_id": "HIT-TEC-045", "title": "Jarvik-7 全人工心脏首次植入人体", "date_start": "1982-12-01", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "Salt Lake City / North America / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "1982 年 12 月 1 日，William DeVries 在犹他大学为 Barney Clark 植入 Jarvik-7 全人工心脏，成为首例面向人体永久植入的全人工心脏；患者存活 112 天后死亡。", "summary": "Jarvik-7 把心脏衰竭从器官依赖推向机械替代，为后续心室辅助装置和全人工心脏留下临床与伦理样本。", "sources": [ "SRC-304" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "患者存活 112 天后死亡，且后续并发症严重；该事件不证明全人工心脏已是成熟替代方案。", "cross_links": [ "HIT-TEC-043", "HIT-TEC-044" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 Crossref/DOI 元数据与 Wikipedia 日期交叉核验。", "created_at": "2026-08-07T10:00:00Z", "updated_at": "2026-08-07T10:00:00Z" }, { "event_id": "HIT-TEC-046", "title": "首例临床左心室辅助装置植入完成", "date_start": "1966-04-21", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "Houston / North America / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "1966 年 4 月 21 日，Michael DeBakey 与 Domingo Liotta 在休斯敦 Methodist Hospital 完成首例临床左心室辅助装置植入，为一例心脏术后心源性休克患者提供约 10 天机械循环支持。", "summary": "该事件把心室辅助从动物实验推进到临床机械循环支持，为人工心脏和心脏移植桥梁策略奠定基础。", "sources": [ "SRC-305" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "首例患者仅获短期支持，后续血栓、感染和装置故障仍是长期风险。", "cross_links": [ "HIT-TEC-043", "HIT-TEC-045", "HIT-POL-019" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed/DOI 与 Wikipedia 日期交叉核验。", "created_at": "2026-08-07T11:00:00Z", "updated_at": "2026-08-07T11:00:00Z" }, { "event_id": "HIT-TEC-047", "title": "首例新生儿 ECMO 成功救治", "date_start": "2017-11", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "California / North America / Global", "path_family": "maintenance", "event_type": "technology", "claim": "1975 年，Robert Bartlett 团队在美国加州大学欧文分校为一名出生后出现严重呼吸衰竭的新生儿首次成功使用体外膜氧合（ECMO），患儿存活并出院，使 ECMO 成为新生儿呼吸衰竭的重要生命支持路径。", "summary": "首例新生儿 ECMO 成功案例把体外生命支持从成人扩展到大动脉和新生儿重症救治。", "sources": [ "SRC-306" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "首个新生儿 ECMO 成功案例没有同期正式病例报告；后续适应症、抗凝和神经结局仍需持续验证。", "cross_links": [ "HIT-TEC-042", "HIT-TEC-043" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 Europe PMC 与历史报告核验，日期按年份记录。；日期补齐：Crossref 2017-11 (published-print, month, v3)", "created_at": "2026-08-07T11:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-019", "title": "FDA 批准首个植入式心室辅助系统", "date_start": "1994-09-30", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "policy", "claim": "1994 年 9 月 30 日，FDA 批准 HeartMate 左心室辅助系统（PMA P920014），成为美国首个获准用于等待心脏移植患者的植入式心室辅助装置。", "summary": "该批准把心室辅助从研究性技术纳入正式医疗器械监管框架。", "sources": [ "SRC-307" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "批准范围是等待心脏移植的过渡支持，不等同于长期替代或治愈心衰。", "cross_links": [ "HIT-TEC-046", "HIT-POL-020" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 FDA PMA 官方数据库核验。", "created_at": "2026-08-07T11:00:00Z", "updated_at": "2026-08-07T11:00:00Z" }, { "event_id": "HIT-POL-020", "title": "FDA 批准 Berlin Heart EXCOR 儿童心室辅助装置", "date_start": "2011-12-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "policy", "claim": "2011 年 12 月 16 日，FDA 通过人道主义器械豁免（HDE H100004）批准 Berlin Heart EXCOR Pediatric 心室辅助装置，成为美国首个获批用于儿童的机械循环支持设备。", "summary": "该批准为等待心脏移植的儿童患者建立了正式机械循环支持路径。", "sources": [ "SRC-308" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "HDE 面向儿科人群，患者数量少，长期安全性和疗效证据仍需积累。", "cross_links": [ "HIT-POL-019", "HIT-POL-021" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 FDA HDE 官方数据库核验。", "created_at": "2026-08-07T11:00:00Z", "updated_at": "2026-08-07T11:00:00Z" }, { "event_id": "HIT-POL-021", "title": "CARMAT 全人工心脏获欧盟 CE 标志", "date_start": "2020-12-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "France / European Union", "region": "Europe / Global", "path_family": "social_composite", "event_type": "policy", "claim": "2020 年 12 月 22 日，CARMAT 的全人工心脏获得欧盟 CE 标志，成为首个获批商业销售的欧盟全人工心脏，用于等待心脏移植患者的过渡支持。", "summary": "CE 标志把全人工心脏从临床研究推进到欧洲商业可用阶段，但仍受适应症和随访限制。", "sources": [ "SRC-309" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "CE 标志支持欧洲过渡使用，不等同于全人工心脏已成为成熟长期替代方案；公司后续财务与临床可用性仍不确定。", "cross_links": [ "HIT-TEC-045", "HIT-POL-019" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 Wayback Machine 存档核验。", "created_at": "2026-08-07T11:00:00Z", "updated_at": "2026-08-07T11:00:00Z" }, { "event_id": "HIT-INS-043", "title": "体外生命支持组织成立", "date_start": "1989", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "institution", "claim": "1989 年，体外生命支持组织（ELSO）成立，开始围绕 ECMO/ECLS 建立跨中心协作、培训、注册表和结果报告基础设施。", "summary": "ELSO 把分散的体外生命支持实践组织为全球性临床证据和治理网络。", "sources": [ "SRC-310" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "成立年份事实清楚，但注册表覆盖范围、数据质量和各国参与度需要持续核验。", "cross_links": [ "HIT-TEC-047", "HIT-SCI-058", "HIT-DEM-007" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-07T12:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-057", "title": "REMATCH 试验发表", "date_start": "2001-11-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "maintenance", "event_type": "technology", "claim": "2001 年 11 月 15 日，REMATCH 试验结果在 NEJM 发表，显示长期植入式左心室辅助装置相比药物治疗可改善不适合心脏移植的终末期心衰患者生存，成为心室辅助装置向长期治疗推进的关键证据。", "summary": "REMATCH 用随机对照证据把机械循环支持从移植桥梁扩展到长期替代方案。", "sources": [ "SRC-311" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "试验改善生存的同时存在感染、出血和装置故障等严重并发症，结果不能直接推广到所有心衰人群。", "cross_links": [ "HIT-TEC-046", "HIT-POL-019", "HIT-POL-020" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-07T12:00:00Z", "updated_at": "2026-08-07T12:00:00Z" }, { "event_id": "HIT-SCI-058", "title": "CESAR 试验发表", "date_start": "2009-10-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom", "region": "Europe / Global", "path_family": "maintenance", "event_type": "technology", "claim": "2009 年 10 月 17 日，CESAR 随机对照试验结果在 Lancet 发表，显示转诊至 ECMO 中心并接受 ECMO 治疗策略的重症成人呼吸衰竭患者，6 个月无严重残疾生存率高于常规机械通气组。", "summary": "CESAR 成为现代成人 ECMO 随机对照证据的基础，推动体外生命支持进入重症呼吸治疗政策议程。", "sources": [ "SRC-312" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "试验比较的是转诊至 ECMO 中心的治疗策略，而非所有患者都实际接受 ECMO；结果需要结合后续 EOLIA 证据理解。", "cross_links": [ "HIT-TEC-047", "HIT-INS-043", "HIT-SCI-059" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T12:00:00Z", "updated_at": "2026-08-07T12:00:00Z" }, { "event_id": "HIT-SCI-059", "title": "EOLIA 试验发表", "date_start": "2018-05-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "France / International", "region": "Europe / Global", "path_family": "maintenance", "event_type": "technology", "claim": "2018 年 5 月 24 日，EOLIA 随机对照试验结果在 NEJM 发表，评估早期 ECMO 与常规机械通气治疗重度 ARDS；60 天死亡率未达到预设统计学显著性，但治疗组交叉使用和绝对风险差异引发持续证据讨论。", "summary": "EOLIA 是成人重度 ARDS 中 ECMO 的核心随机对照证据，其阴性统计结果与临床意义争议并存。", "sources": [ "SRC-313" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "试验因预设停止规则提前终止，且对照组有患者交叉接受 ECMO；结果不能简单读为 ECMO 无效或完全有效。", "cross_links": [ "HIT-SCI-058", "HIT-INS-043", "HIT-DEM-007" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T12:00:00Z", "updated_at": "2026-08-07T12:00:00Z" }, { "event_id": "HIT-DEM-007", "title": "ELSO 注册表报告 10 万名幸存者", "date_start": "2024-02-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "demographic", "claim": "2024 年 2 月 1 日，ELSO Registry International Report 2022 在 ASAIO Journal 发表，报告注册表累计超过 10 万名体外生命支持幸存者，成为体外生命支持长期随访和结果治理的大型数据基础设施里程碑。", "summary": "该报告显示 ELSO 注册表已从早期病例收集发展为覆盖全球、可支持研究和监管的大规模结果数据基础设施。", "sources": [ "SRC-314" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "注册表覆盖规模大，但幸存者定义、长期神经结局和跨中心数据质量仍需独立审查。", "cross_links": [ "HIT-INS-043", "HIT-SCI-059" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T12:00:00Z", "updated_at": "2026-08-07T12:00:00Z" }, { "event_id": "HIT-TEC-048", "title": "连续低温灌注实现犬肾长时间保存", "date_start": "1967-09-09", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "suspension", "event_type": "technology", "claim": "1967 年 9 月 9 日，Belzer 等人在 Lancet 报告通过连续低温灌注实现犬肾保存 24 至 72 小时，为器官机器灌注保存奠定基础。", "summary": "该研究把器官保存从静态冷藏扩展到可控连续灌注，是现代机器灌注保存的重要起点。", "sources": [ "SRC-315" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "该结果是犬肾模型，不等同于人类器官保存标准。", "cross_links": [ "HIT-SCI-060", "HIT-TEC-019" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T13:00:00Z", "updated_at": "2026-08-07T13:00:00Z" }, { "event_id": "HIT-SCI-060", "title": "UW 溶液实现犬肾 72 小时冷保存", "date_start": "1988-08", "date_type": "approx", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "suspension", "event_type": "technology", "claim": "1988 年 8 月，UW 溶液论文在 Transplantation 发表，报告 UW 溶液可实现犬肾 72 小时冷保存，成为器官冷保存的重要里程碑。", "summary": "UW 溶液把冷保存窗口从数小时扩展到 72 小时级，重塑了器官运输和移植组织方式。", "sources": [ "SRC-316" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "UW 溶液显著延长冷保存时间，但不同器官、供体类型和保存技术仍有差异。", "cross_links": [ "HIT-TEC-048", "HIT-SCI-062" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。；日期补齐：Crossref 1988-08 (published-print, month, v3)", "created_at": "2026-08-07T13:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-SCI-061", "title": "PROCEED II 心脏体外灌注试验发表", "date_start": "2015-06-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Europe", "region": "North America / Europe / Global", "path_family": "suspension", "event_type": "technology", "claim": "2015 年 6 月 27 日，PROCEED II 随机非劣效试验在 Lancet 发表，评估 Organ Care System 对供体心脏的常温离体灌注与标准冷保存；30 天患者和移植物生存率分别为 94% 与 97%。", "summary": "PROCEED II 把心脏体外灌注从技术演示推进到多中心随机对照证据。", "sources": [ "SRC-317" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "样本量小、开放标签，非劣效边界和长期结局需继续验证。", "cross_links": [ "HIT-TEC-043", "HIT-POL-019" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T13:00:00Z", "updated_at": "2026-08-07T13:00:00Z" }, { "event_id": "HIT-SCI-062", "title": "COPE 常温肝脏保存随机试验发表", "date_start": "2018-04-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Europe", "region": "Europe / Global", "path_family": "suspension", "event_type": "technology", "claim": "2018 年 4 月 18 日，Nasralla 等人在 Nature 发表 COPE 随机试验，显示相比标准冷保存，常温机器灌注保存的移植肝肝细胞损伤标志物释放降低约 50%，弃用率降低约 50%，平均保存时间延长 54%。", "summary": "COPE 为肝脏常温机器灌注提供了关键随机证据，并重新定义器官保存从静态等待转向功能性体外维护。", "sources": [ "SRC-318" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "试验显示损伤和弃用改善，但胆道并发症、移植物和患者长期存活无显著差异。", "cross_links": [ "HIT-SCI-060", "HIT-TEC-049" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T13:00:00Z", "updated_at": "2026-08-07T13:00:00Z" }, { "event_id": "HIT-TEC-049", "title": "人类肝脏体外保存三天后成功移植", "date_start": "2022-05-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Switzerland / International", "region": "Europe / Global", "path_family": "suspension", "event_type": "technology", "claim": "2022 年 5 月 31 日，Clavien 等人在 Nature Biotechnology 报告，一枚被多中心弃用的人类供肝经体外常温机器灌注保存数天后成功移植，患者 1 年随访未出现排异或胆道损伤，提示保存窗口可能扩展到 10 天。", "summary": "该案例首次展示人类器官体外常温维护可跨越数天并完成移植，是器官保存从小时窗口走向长期体外维护的重要节点。", "sources": [ "SRC-319" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "为单个被弃用肝脏的成功案例，不能证明所有肝脏都能安全保存数天；需更大规模临床验证。", "cross_links": [ "HIT-SCI-062", "HIT-TEC-019" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T13:00:00Z", "updated_at": "2026-08-07T13:00:00Z" }, { "event_id": "HIT-SCI-063", "title": "甘油低温保存精子复苏发现发表", "date_start": "1949-10-15", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United Kingdom", "region": "Europe / Global", "path_family": "suspension", "event_type": "technology", "claim": "1949 年 10 月 15 日，Polge、Smith 与 Parkes 在 Nature 报告甘油可使精子在低温冷冻后复苏，成为现代低温生物学的奠基性发现。", "summary": "甘油低温保存把细胞和组织保存从经验尝试转向可复现的低温生物学方法。", "sources": [ "SRC-320" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "该发现来自家禽精子，不代表所有细胞和组织都能低温保存。", "cross_links": [ "HIT-TEC-015", "HIT-TEC-019", "HIT-TEC-021" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T14:00:00Z", "updated_at": "2026-08-07T14:00:00Z" }, { "event_id": "HIT-SCI-064", "title": "冷冻人类胚胎首次建立妊娠", "date_start": "1983-10", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Australia", "region": "Oceania / Global", "path_family": "suspension", "event_type": "technology", "claim": "1983 年 10 月，Trounson 与 Mohr 在 Nature 报告人类八细胞胚胎经冷冻保存、解冻和移植后建立妊娠，把低温保存引入人类生殖未来选择权。", "summary": "首例冷冻人类胚胎妊娠表明生殖材料可被暂停并恢复，为生育力保存和未来选择权提供基础。", "sources": [ "SRC-321" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "首例妊娠最终在 24 周因感染终止；胚胎冷冻作为生殖未来选择权仍需长期随访。", "cross_links": [ "HIT-SCI-063", "HIT-TEC-015" ], "chapter": "低温保存、分子机制与数字永生", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。；日期补齐：Crossref 1983-10 (published-print, month, v3)", "created_at": "2026-08-07T14:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-081", "title": "Maastricht 非心跳捐献者分类提出", "date_start": "1995-10", "date_type": "approx", "period_id": "period-20th-century", "civilization": "Netherlands / International", "region": "Europe / Global", "path_family": "social_composite", "event_type": "thought", "claim": "1995 年 10 月，Kootstra 等人在《Transplantation Proceedings》提出非心跳捐献者分类（Maastricht 分类），为循环死亡后器官捐献建立可操作的医学分类框架。", "summary": "Maastricht 分类把循环死亡后捐献从个案实践整理为可研究、可治理的制度框架。", "sources": [ "SRC-322" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "分类是实践性框架，各国对死亡判定、等待期和伦理接受度仍不一致。", "cross_links": [ "HIT-SCI-053", "HIT-POL-018", "HIT-TEC-050" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 元数据核验。", "created_at": "2026-08-07T14:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-050", "title": "美国报告常温区域灌注用于 DCD 心脏移植", "date_start": "2021-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2021 年 11 月，美国早期经验在 Journal of Heart and Lung Transplantation 发表，报告 15 例采用常温区域灌注（NRP）的循环死亡后心脏移植，30 天时全部患者存活，显示 DCD 供心在美国进入临床实践。", "summary": "该经验把 NRP 从动物和欧洲实践推进到美国心脏移植临床，扩大了循环死亡后供心使用路径。", "sources": [ "SRC-323" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "早期经验样本量小，中长期结果和伦理边界仍需验证。", "cross_links": [ "HIT-POL-018", "HIT-THT-081", "HIT-TEC-051" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。；日期补齐：Crossref 2021-11 (published-print, month, v3)", "created_at": "2026-08-07T14:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-051", "title": "JAMA Surgery 报告 NRP 扩展 DCD 肝脏移植", "date_start": "2024-06-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2024 年 6 月 1 日，JAMA Surgery 发表研究，显示常温区域灌注可扩展来自循环死亡捐献者的肝脏移植，降低供肝弃用并扩大移植可用器官池。", "summary": "该研究把 NRP 肝脏移植从单中心经验推向更大规模的美国临床证据。", "sources": [ "SRC-324" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "研究显示 NRP 可扩展 DCD 供肝使用，但不同国家监管和死亡判定标准仍不统一。", "cross_links": [ "HIT-TEC-050", "HIT-THT-081", "HIT-SCI-062" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已做 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T14:00:00Z", "updated_at": "2026-08-07T14:00:00Z" }, { "event_id": "HIT-POL-022", "title": "美国 Medicare 将终末期肾病纳入公共覆盖", "date_start": "1972-10-30", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "policy", "claim": "1972 年 10 月 30 日，美国《社会保障修正案》签署，将终末期肾病纳入 Medicare 资格，使肾透析与肾移植成为联邦公共支付覆盖的长期生命维持路径。", "summary": "该制度把肾衰竭从家庭财务灾难和选择性治疗问题转化为可持续的公共健康基础设施，也首次把一种器官替代治疗作为普遍权利纳入社会支持系统。", "sources": [ "SRC-325" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "法案签署与资格生效不同步：ESRD Medicare 资格自 1973 年 7 月 1 日起生效；公共覆盖不等于透析质量、移植可及性或长期生存得到保证。", "cross_links": [ "HIT-POL-023", "HIT-POL-024" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 GovInfo 原始法规页核验。", "created_at": "2026-08-07T15:00:00Z", "updated_at": "2026-08-07T15:00:00Z" }, { "event_id": "HIT-POL-023", "title": "美国《医疗器械修正案》确立人工器官上市前监管", "date_start": "1976-05-28", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "policy", "claim": "1976 年 5 月 28 日，美国《医疗器械修正案》签署，建立医疗器械分类和上市前审批框架，把人工心脏、心室辅助装置、透析机等维持生命设备纳入联邦监管。", "summary": "该修正案第一次把人工器官与生命支持器械作为高风险管理对象，要求用证据证明安全有效后才能进入市场。", "sources": [ "SRC-326" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "监管框架的建立不自动保证设备长期疗效、患者可及或公平分配；历史器械仍需按分类、PMA 和上市后数据持续审查。", "cross_links": [ "HIT-POL-019", "HIT-TEC-045", "HIT-TEC-046" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 GovInfo 原始法规页核验。", "created_at": "2026-08-07T15:00:00Z", "updated_at": "2026-08-07T15:00:00Z" }, { "event_id": "HIT-POL-024", "title": "美国《国家器官移植法》建立 OPTN 框架", "date_start": "1984-10-19", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "policy", "claim": "1984 年 10 月 19 日，美国《国家器官移植法》签署，禁止有偿器官移植交易，并要求建立器官移植工作组和器官获取与移植网络（OPTN），为全国器官分配建立制度框架。", "summary": "该法案把器官短缺和分配从个案医疗决策提升为国家治理问题，为器官保存、移植等待名单和公平分配提供法律基础。", "sources": [ "SRC-327" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "OPTN 由 UNOS 承担运营的合同 1986 年才建立；法案确立了制度方向，但并未解决器官短缺或分配公平。", "cross_links": [ "HIT-POL-022", "HIT-TEC-044" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 GovInfo 原始法规页核验。", "created_at": "2026-08-07T15:00:00Z", "updated_at": "2026-08-07T15:00:00Z" }, { "event_id": "HIT-POL-025", "title": "FDA 批准 HeartMate II 用于目的地治疗", "date_start": "2010-01-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "policy", "claim": "2010 年 1 月 20 日，FDA 批准 HeartMate II LVAS 补充适应症，用于不适合心脏移植的 NYHA IIIB/IV 期终末期心衰患者，把心室辅助装置从移植过渡支持推进为长期目的地治疗。", "summary": "该批准把机械循环支持正式定位为长期生命维持方案，使人工器官不再只是等待生物移植的桥梁。", "sources": [ "SRC-330" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "目的地治疗延长了无移植患者的生存窗口，但伴随设备故障、感染、卒中、出血和护理负担等长期风险。", "cross_links": [ "HIT-POL-019", "HIT-SCI-057", "HIT-DEM-008" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 FDA PMA 官方数据库核验。", "created_at": "2026-08-07T15:00:00Z", "updated_at": "2026-08-07T15:00:00Z" }, { "event_id": "HIT-DEM-008", "title": "INTERMACS 发布机械循环支持首份年度报告", "date_start": "2008-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "maintenance", "event_type": "demographic", "claim": "2008 年 10 月，INTERMACS 第一份年度报告发表，汇总机械循环支持设备植入的基线特征、风险分层与早期结果，为人工器官和机械循环支持的长期随访建立全国性数据基础设施。", "summary": "该报告让心室辅助装置和全人工心脏不再只靠单中心病例，而能进入可比较、可审查的长期结果治理框架。", "sources": [ "SRC-328" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "首份报告基于早期注册队列，入选标准、设备定义和结果测量随年份演化；早期结果不能直接推广为当前或未来长期存活率。", "cross_links": [ "HIT-POL-019", "HIT-POL-025", "HIT-SCI-057", "HIT-DEM-007" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 PubMed 与 Crossref/DOI 元数据核验。；日期补齐：Crossref 2008-10 (published-print, month, v3)", "created_at": "2026-08-07T15:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-026", "title": "国家科学院报告系统审查人工心脏政策与伦理", "date_start": "1991-01-01", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "policy", "claim": "1991 年，美国国家科学院发布《The Artificial Heart: Prototypes, Policies, and Patients》，系统审查人工心脏的技术状态、患者选择、政策后果和伦理问题，把全人工器官从技术宣传拉回可审查的公共决策框架。", "summary": "该报告标志人工心脏讨论从能否实现转向谁应受益、如何选择患者、如何治理失败与长期成本的伦理和政策问题。", "sources": [ "SRC-329" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "报告提出伦理与政策框架，但其技术判断基于当时临床证据，不能当作当前人工心脏可行性的终判。", "cross_links": [ "HIT-TEC-045", "HIT-POL-025", "HIT-POL-023" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 Crossref/DOI 元数据核验。；日期补齐：Crossref 1991-01-01 (published-print, day, v3)", "created_at": "2026-08-07T15:00:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-SCI-065", "title": "MOMENTUM 3 两年结果支持磁悬浮心室辅助装置", "date_start": "2018-04-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "maintenance", "event_type": "technology", "claim": "2018 年 4 月 12 日，NEJM 发表 MOMENTUM 3 两年结果，显示 HeartMate 3 磁悬浮左心室辅助装置在终末期心衰患者中，卒中或设备故障等复合终点优于轴流泵 HeartMate II，为新一代长期机械循环支持提供随机证据。", "summary": "该结果把心室辅助装置从短期桥接证据推向可与长期替代方案比较的随机试验证据。", "sources": [ "SRC-331" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "两年结果不等于长期疗效终点；患者选择、中心经验和设备代际差异仍会影响真实世界结果。", "cross_links": [ "HIT-SCI-057", "HIT-POL-025", "HIT-DEM-008" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T16:00:00Z", "updated_at": "2026-08-07T16:00:00Z" }, { "event_id": "HIT-DEM-009", "title": "STS-INTERMACS 2019 年度报告发布", "date_start": "2020-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "maintenance", "event_type": "demographic", "claim": "2020 年 3 月，STS/INTERMACS 2019 年度报告发表，记录机械循环支持设备与适应症的变化，显示心室辅助装置实践从桥接移植逐步转向目的地治疗和长期维持。", "summary": "该报告把人工心脏长期使用从个案经验提升为可追踪、可比较的注册表治理数据。", "sources": [ "SRC-332" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "注册表结果受入选中心、设备时代和报告偏差影响；年度报告描述趋势，不等同于前瞻性因果证据。", "cross_links": [ "HIT-DEM-008", "HIT-POL-025", "HIT-SCI-065" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 PubMed 与 Crossref/DOI 元数据核验。；日期补齐：Crossref 2020-03 (published-print, month, v3)", "created_at": "2026-08-07T16:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-027", "title": "2022 年 AHA/ACC/HFSA 心衰指南纳入机械循环支持建议", "date_start": "2022-05-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "policy", "claim": "2022 年 5 月 3 日，AHA/ACC/HFSA 发布心衰管理指南，系统纳入左心室辅助装置与机械循环支持的患者选择、目的地治疗和长期随访建议，把人工器官长期使用写入临床治理标准。", "summary": "该指南为心室辅助装置和人工心脏的长期使用提供了患者选择与随访框架。", "sources": [ "SRC-333" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "指南是专家共识与现有证据的综合，不等同于个体决策；设备适应症和可及性仍受支付、医疗体系和个人情况约束。", "cross_links": [ "HIT-POL-025", "HIT-SCI-057", "HIT-DEM-009" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 PubMed 与 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T16:00:00Z", "updated_at": "2026-08-07T16:00:00Z" }, { "event_id": "HIT-POL-028", "title": "2023 年 ISHLT 机械循环支持指南更新", "date_start": "2023-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "2023 年 7 月，ISHLT 发布机械循环支持指南 10 年更新，覆盖患者选择、设备类型、并发症管理、撤除治疗和长期随访，成为人工心脏与心室辅助长期使用的重要国际指南。", "summary": "该指南把人工器官长期维护从单一中心经验推进到国际共识治理。", "sources": [ "SRC-334" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "指南综合当时证据，但人工器官领域设备更新快，单中心经验与全球注册数据仍需持续校准。", "cross_links": [ "HIT-POL-027", "HIT-POL-025", "HIT-DEM-010" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 PubMed 与 Crossref/DOI 元数据核验。；日期补齐：Crossref 2023-07 (published-print, month, v3)", "created_at": "2026-08-07T16:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-DEM-010", "title": "STS-INTERMACS 2023 年度报告聚焦磁悬浮设备", "date_start": "2024-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "maintenance", "event_type": "demographic", "claim": "2024 年 1 月，STS/INTERMACS 2023 年度报告发表，聚焦磁悬浮心室辅助设备时代的结果与风险，显示注册表已成为追踪新一代人工心脏长期生存和并发症的核心基础设施。", "summary": "该报告把设备换代纳入长期随访治理，使磁悬浮心室辅助的生存和并发症可被持续比较。", "sources": [ "SRC-335" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "报告反映注册中心入组患者，可能不完全代表未入组人群；设备比较仍受时代、适应症和患者选择影响。", "cross_links": [ "HIT-SCI-065", "HIT-DEM-009", "HIT-POL-028" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 PubMed 与 Crossref/DOI 元数据核验。；日期补齐：Crossref 2024-01 (published-print, month, v3)", "created_at": "2026-08-07T16:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-DEM-011", "title": "STS-INTERMACS 2025 年度报告聚焦老年患者结局", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "demographic", "claim": "2026 年 1 月，STS/INTERMACS 2025 年度报告发表，聚焦老年患者的长期结局、风险分层和护理负担，把机械循环支持的长期生存治理与老龄化社会的公平问题联系起来。", "summary": "该报告把老年患者的选择、功能结局和照护负担纳入人工器官长期治理议程。", "sources": [ "SRC-336" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "老年患者定义、选择偏倚和功能结局测量仍在演化；报告描述注册队列趋势，不证明设备应自动扩展至所有老年患者。", "cross_links": [ "HIT-DEM-010", "HIT-POL-027", "HIT-POL-026" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 PubMed 与 Crossref/DOI 元数据核验。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-07T16:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-029", "title": "联合国通过马德里老龄问题国际行动计划", "date_start": "2002-04-08", "date_end": "2002-04-12", "date_type": "range", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "2002 年 4 月 8 日至 12 日，联合国第二次老龄问题世界大会在西班牙马德里举行，通过《政治宣言》和《马德里老龄问题国际行动计划》，把积极老龄、健康福祉和支持性环境纳入全球政策框架。", "summary": "该计划首次把老龄化从人口问题提升为发展、健康和权利治理议程。", "sources": [ "SRC-337" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "计划是国际政策共识，不具有强制约束力；各国执行、监测和资源投入差异很大。", "cross_links": [ "HIT-POL-030", "HIT-POL-001" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用联合国原始 PDF 核验。", "created_at": "2026-08-07T17:00:00Z", "updated_at": "2026-08-07T17:00:00Z" }, { "event_id": "HIT-POL-030", "title": "WHO 发布积极老龄化政策框架", "date_start": "2002", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Global", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "2002 年，WHO 发布《Active ageing: a policy framework》，提出以健康、参与和安全为支柱的积极老龄化政策框架，把老年健康从疾病治疗转向功能能力与社会参与。", "summary": "该框架把健康寿命纳入公共政策，并成为后续全球老龄治理的概念基础。", "sources": [ "SRC-338" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "框架是政策概念，不证明任何单一干预能延长人类寿命。", "cross_links": [ "HIT-POL-029", "HIT-POL-001" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 WHO IRIS 官方记录核验。", "created_at": "2026-08-07T17:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-POL-031", "title": "WHO 发布全球老龄与健康战略及行动计划", "date_start": "2017-01-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "2017 年 1 月 2 日，WHO 发布《Global strategy and action plan on ageing and health》，提出 2016-2020 年最大化功能能力、发展年龄友好环境、整合长期照护和建立健康老龄化测量系统。", "summary": "该战略把健康老龄化从概念转化为可执行的多部门行动框架。", "sources": [ "SRC-1785" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "正式出版物日期为 2017 年 1 月 2 日，战略草案与 WHA69.3 决议此前已在 2016 年通过；政策发布不等于实现。", "cross_links": [ "HIT-POL-029", "HIT-POL-030", "HIT-INS-044" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 WHO 官方出版物页面核验。", "created_at": "2026-08-07T17:00:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-044", "title": "世界卫生大会批准健康老龄化十年", "date_start": "2020-08-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "2020 年 8 月 3 日，第七十三届世界卫生大会通过 WHA73(12) 决定，批准 2020-2030 年健康老龄化十年，并要求总干事向联合国大会提交建议。", "summary": "该决定把健康老龄化十年从 WHO 内部议程推进为提交联合国审议的全球治理行动。", "sources": [ "SRC-340" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "决定确立十年框架，但最终联合国十年由后续 A/RES/75/131 决议正式宣布。", "cross_links": [ "HIT-POL-032", "HIT-POL-031" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 WHO 官方决议 PDF 核验。", "created_at": "2026-08-07T17:00:00Z", "updated_at": "2026-08-07T17:00:00Z" }, { "event_id": "HIT-POL-032", "title": "联合国大会宣布 2021-2030 健康老龄化十年", "date_start": "2020-12-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "2020 年 12 月 21 日，联合国大会通过 A/RES/75/131 决议，宣布 2021-2030 年为联合国健康老龄化十年，要求 WHO 牵头实施、监测和报告。", "summary": "该决议把健康老龄化上升为联合国十年议程，强调延长健康、功能和自主生活。", "sources": [ "SRC-341" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "十年决议是国际治理框架，不是医学证据或延寿承诺；各国实施仍取决于政治、财政和能力。", "cross_links": [ "HIT-INS-044", "HIT-POL-002", "HIT-DEM-012" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 UNDOCS 与 WHO 页面交叉核验。", "created_at": "2026-08-07T17:00:00Z", "updated_at": "2026-08-07T17:00:00Z" }, { "event_id": "HIT-DEM-012", "title": "WHO 发布健康老龄化十年基线报告", "date_start": "2021-01-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Global", "region": "Global", "path_family": "social_composite", "event_type": "demographic", "claim": "2021 年 1 月 14 日，WHO 发布《Decade of Healthy Ageing: Baseline Report》，为 2021-2030 年健康老龄化十年建立全球基线，覆盖功能能力、年龄友好环境、照护系统和测量指标。", "summary": "该报告为十年行动提供可追踪基线，把政策目标转化为可监测的全球证据框架。", "sources": [ "SRC-342" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "基线报告基于 2020 年前数据，且各国指标覆盖不均；后续进展报告才能验证十年目标是否达成。", "cross_links": [ "HIT-POL-032", "HIT-INS-044", "HIT-POL-001" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 WHO 官方出版物页面核验。", "created_at": "2026-08-07T17:00:00Z", "updated_at": "2026-08-07T17:00:00Z" }, { "event_id": "HIT-SCI-066", "title": "Thomson 团队建立首个人类胚胎干细胞系", "date_start": "1998-11-06", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "Wisconsin / Laboratory", "path_family": "reconstruction", "event_type": "technology", "claim": "1998 年 11 月 6 日，Thomson 等人在 Science 报告建立可长期培养的人类胚胎干细胞系，证明人胚来源细胞可维持多能性并分化出三个胚层谱系，为再生医学和细胞治疗建立细胞来源基础。", "summary": "该里程碑把胚胎干细胞从啮齿类模型扩展到人类，使组织修复和细胞替代治疗成为可被系统研究的医学方向。", "sources": [ "SRC-343" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "胚胎干细胞系建立不等于成熟疗法；免疫排斥、肿瘤风险和伦理监管仍是转化门槛。", "cross_links": [ "HIT-SCI-027", "HIT-SCI-067" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T18:00:00Z", "updated_at": "2026-08-07T18:00:00Z" }, { "event_id": "HIT-SCI-067", "title": "人类成纤维细胞被重编程为诱导多能干细胞", "date_start": "2007-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Japan", "region": "Kyoto / Laboratory", "path_family": "reconstruction", "event_type": "technology", "claim": "2007 年 11 月，Takahashi 与 Yamanaka 团队在 Cell 报告，用 OCT4、SOX2、KLF4 与 c-MYC 将成人皮肤成纤维细胞重编程为诱导多能干细胞，把重编程技术从小鼠扩展到人类。", "summary": "人类 iPS 细胞使患者特异细胞、疾病建模和自体细胞治疗成为可能，但插入性基因和肿瘤风险仍需安全治理。", "sources": [ "SRC-344" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "原初方法使用病毒整合载体；iPS 不直接等于人体返老还童。", "cross_links": [ "HIT-SCI-007", "HIT-SCI-066", "HIT-SCI-028" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 Crossref/DOI 元数据核验。；日期补齐：Crossref 2007-11 (published-print, month, v3)", "created_at": "2026-08-07T18:00:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-SCI-068", "title": "Geron 启动首个人类胚胎干细胞人体临床试验", "date_start": "2010-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America", "path_family": "reconstruction", "event_type": "technology", "claim": "2010 年 10 月，Geron 在 ClinicalTrials.gov 注册并启动 GRNOPC1 脊髓损伤一期研究，成为首个进入人体临床试验的人类胚胎干细胞来源细胞治疗。", "summary": "该试验把胚胎干细胞从实验室推向人体安全验证，也把伦理、监管和商业化风险带进再生医学转化。", "sources": [ "SRC-345" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "注册日期与首次给药日期存在报道差异；一期研究证明安全性，不代表疗效。", "cross_links": [ "HIT-SCI-066", "HIT-FAI-004" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 ClinicalTrials.gov API v2 核验。", "created_at": "2026-08-07T18:00:00Z", "updated_at": "2026-08-07T18:00:00Z" }, { "event_id": "HIT-INS-045", "title": "山中伸弥与格登获诺贝尔生理学或医学奖", "date_start": "2012-10-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Japan / United Kingdom / Sweden", "region": "Stockholm / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2012 年 10 月 8 日，诺贝尔奖委员会宣布将生理学或医学奖授予 John Gurdon 与 Shinya Yamanaka，表彰其发现成熟细胞可被重编程为多能状态。", "summary": "该奖项把细胞重编程确立为生命科学和再生医学的主流研究纲领。", "sources": [ "SRC-346" ], "evidence_grade": "S", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "奖项确认科学贡献，不证明细胞重编程已经转化为成熟的延寿或器官重建治疗。", "cross_links": [ "HIT-SCI-007", "HIT-SCI-067" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-07T18:00:00Z", "updated_at": "2026-08-07T18:00:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-SCI-069", "title": "日本实施首例 iPS 细胞来源视网膜色素上皮移植", "date_start": "2014-09-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Japan", "region": "Kobe / Asia", "path_family": "reconstruction", "event_type": "technology", "claim": "2014 年 9 月 12 日，Nature 新闻报道日本患者接受 iPS 细胞来源视网膜色素上皮细胞移植，成为全球首例 iPS 细胞来源组织的人体移植。", "summary": "该事件把 iPS 从实验室细胞推进到人体组织移植，同时暴露监管、伦理和长期随访挑战。", "sources": [ "SRC-347" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "事件基于同期新闻与后续学术报道；首例移植不等于可推广疗法，长期安全仍需随访。", "cross_links": [ "HIT-SCI-067", "HIT-SCI-068" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-07T18:00:00Z", "updated_at": "2026-08-07T18:00:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-INS-046", "title": "FDA 批准首个 CAR-T 疗法 Kymriah", "date_start": "2017-08-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2017 年 8 月 30 日，FDA 批准 Kymriah（tisagenlecleucel），成为美国首个获批的 CAR-T 细胞疗法和首个含基因治疗步骤的获批治疗。", "summary": "该批准把个性化细胞工程治疗纳入正式监管路径，为细胞与基因疗法建立了临床转化模板。", "sources": [ "SRC-348" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "批准针对特定血液肿瘤和年龄人群，不代表细胞疗法普遍适用于复杂疾病或抗衰老。", "cross_links": [ "HIT-SCI-068", "HIT-INS-021" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T18:00:00Z", "updated_at": "2026-08-07T18:00:00Z" }, { "event_id": "HIT-SCI-070", "title": "首个人类基因治疗试验方案获批", "date_start": "1990-02-23", "date_type": "exact", "period_id": "period-20th-century", "civilization": "United States", "region": "NIH / North America", "path_family": "reconstruction", "event_type": "technology", "claim": "1990 年 2 月 23 日，ADA 人类基因治疗临床试验原始覆盖备忘录记录了首个获批的人类基因治疗方案，目标是用基因修饰 T 细胞治疗 ADA 重症联合免疫缺陷。", "summary": "该方案把基因改造细胞从概念推进到受监管人体试验，成为后续细胞与基因治疗转化的起点。", "sources": [ "SRC-349" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "备忘录记录方案获批，不等于疗效证明；首例患者治疗发生在后续临床试验阶段。", "cross_links": [ "HIT-TEC-005", "HIT-INS-021" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 Crossref/DOI 元数据核验。", "created_at": "2026-08-07T19:00:00Z", "updated_at": "2026-08-07T19:00:00Z" }, { "event_id": "HIT-INS-047", "title": "FDA 批准首个自体细胞免疫治疗 Provenge", "date_start": "2010-04-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2010 年 4 月 29 日，FDA 批准 Provenge（sipuleucel-T），成为美国首个获批的自体细胞免疫治疗，用于转移性去势抵抗性前列腺癌。", "summary": "Provenge 确立了个体化细胞产品进入正式监管审评和商业化的路径。", "sources": [ "SRC-350" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "批准针对特定肿瘤人群，不代表细胞治疗普遍成熟；生产成本和商业可持续性后续成为重要挑战。", "cross_links": [ "HIT-SCI-068", "HIT-SCI-066" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T19:00:00Z", "updated_at": "2026-08-07T19:00:00Z" }, { "event_id": "HIT-SCI-071", "title": "CiRA 开始分发临床级 iPS 细胞储备", "date_start": "2015-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Japan", "region": "Kyoto / Asia", "path_family": "reconstruction", "event_type": "technology", "claim": "CiRA 自 2013 年起推进 iPS Cell Stock 项目，并于 2015 年 8 月开始向医疗和科研机构分发临床级 iPS 细胞，为异体再生医学建立可复用的细胞库基础设施。", "summary": "临床级 iPS 细胞储备把 iPS 技术从个体定制转向可规模化的异体细胞供给。", "sources": [ "SRC-351" ], "evidence_grade": "S", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "细胞库覆盖的 HLA 多样性和长期质量治理仍需持续评估。", "cross_links": [ "HIT-SCI-067", "HIT-SCI-069" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-07T19:00:00Z", "updated_at": "2026-08-07T19:00:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-SCI-072", "title": "首例 iPS 细胞来源心肌细胞片移植进入人体", "date_start": "2020-01-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Japan", "region": "Osaka / Asia", "path_family": "reconstruction", "event_type": "technology", "claim": "2020 年 1 月 30 日，报道显示大阪大学团队将 iPS 细胞来源心肌细胞片移植给一名心脏病患者，成为 iPS 细胞来源心肌组织进入人体的首个临床案例。", "summary": "该手术把 iPS 细胞从视网膜和神经方向扩展到心脏组织修复，是细胞治疗器官化的重要节点。", "sources": [ "SRC-352" ], "evidence_grade": "T", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "事件基于同期新闻报道；首例个案和早期随访不等于疗效证明。", "cross_links": [ "HIT-SCI-067", "HIT-SCI-071" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-07T19:00:00Z", "updated_at": "2026-08-07T19:00:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-SCI-073", "title": "iPS 细胞来源多巴胺能细胞治疗帕金森病 I/II 期结果发表", "date_start": "2025-04-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Japan / International", "region": "Kyoto / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2025 年 4 月 16 日，Nature 发表 iPS 细胞来源多巴胺能细胞治疗帕金森病的 I/II 期试验，报告异体 iPS 细胞来源多巴胺能前体细胞移植的安全性和初步功能信号。", "summary": "该试验把 iPS 细胞疗法推进到神经系统疾病的人体验证，但小样本和早期随访限制结论强度。", "sources": [ "SRC-353" ], "evidence_grade": "S", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "I/II 期结果以安全性为主，初步功能改善不等于治愈或可推广治疗。", "cross_links": [ "HIT-SCI-072", "HIT-SCI-071", "HIT-SCI-069" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-07T19:00:00Z", "updated_at": "2026-08-07T19:00:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-INS-048", "title": "日本药事委员会建议推进首个异体 iPS 细胞产品审批", "date_start": "2026-02-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Japan", "region": "Japan / Asia", "path_family": "reconstruction", "event_type": "institution", "claim": "2026 年 2 月 24 日，AABB News 报道日本药事委员会建议推进 Amchepry（帕金森病）与 ReHeart（严重心衰）两个异体 iPS 细胞产品的条件性批准程序。", "summary": "该建议若转化为正式许可，将标志 iPS 细胞疗法从试验转向条件性监管商品化。", "sources": [ "SRC-354" ], "evidence_grade": "S", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "药事委员会建议不是最终许可；正式批准、长期疗效和安全性数据仍待验证。", "cross_links": [ "HIT-SCI-073", "HIT-SCI-072" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "本地复核修正：该事件为可报道的制度事实，证据等级由 M 改为 S。本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-07T19:00:00Z", "updated_at": "2026-08-07T19:00:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-INS-049", "title": "FDA 批准首个大 B 细胞淋巴瘤 CAR-T 疗法 Yescarta", "date_start": "2017-10-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2017 年 10 月 18 日，FDA 批准 axicabtagene ciloleucel（Yescarta），用于经两线或以上系统治疗后的复发或难治性大 B 细胞淋巴瘤成人患者，成为美国首个获批用于大 B 细胞淋巴瘤的 CAR-T 疗法。", "summary": "Yescarta 把 CAR-T 从首例白血病批准扩展到淋巴瘤领域，推动细胞治疗进入更广泛的血液肿瘤市场。", "sources": [ "SRC-355" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "批准基于单臂或关键试验的应答数据，长期生存和真实世界安全性仍需随访。", "cross_links": [ "HIT-INS-046", "HIT-INS-021" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T20:00:00Z", "updated_at": "2026-08-07T20:00:00Z" }, { "event_id": "HIT-INS-050", "title": "FDA 批准首个全身性基因疗法 Zolgensma", "date_start": "2019-05-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2019 年 5 月 24 日，FDA 批准 onasemnogene abeparvovec（Zolgensma），用于两岁以下脊髓性肌萎缩患儿，成为美国首个获批的全身性基因疗法。", "summary": "Zolgensma 确立 AAV 基因替代疗法进入正式监管和商业化的路径，也暴露了高价、数据完整性和递送安全等治理问题。", "sources": [ "SRC-356" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "批准针对特定儿童罕见病；长期疗效、免疫反应和支付可持续性仍需持续监测。", "cross_links": [ "HIT-INS-021", "HIT-TEC-005" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T20:00:00Z", "updated_at": "2026-08-07T20:00:00Z" }, { "event_id": "HIT-INS-051", "title": "FDA 批准首个多发性骨髓瘤细胞基因疗法 Abecma", "date_start": "2021-03-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2021 年 3 月 26 日，FDA 批准 idecabtagene vicleucel（Abecma），成为首个获批的 BCMA 靶向 CAR-T 细胞基因疗法，用于复发或难治性多发性骨髓瘤成人患者。", "summary": "Abecma 把 CAR-T 从 B 细胞肿瘤扩展到浆细胞肿瘤，显示个性化细胞疗法在更多血液恶性肿瘤中的监管可行性。", "sources": [ "SRC-357" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "批准基于有限人群应答数据，长期生存、毒性和真实世界可及性仍需验证。", "cross_links": [ "HIT-INS-046", "HIT-INS-049" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T20:00:00Z", "updated_at": "2026-08-07T20:00:00Z" }, { "event_id": "HIT-INS-052", "title": "FDA 批准 CAR-T 提前至二线治疗大 B 细胞淋巴瘤", "date_start": "2022-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2022 年 4 月 1 日，FDA 批准 axicabtagene ciloleucel（Yescarta）用于一线免疫化疗后复发或 12 个月内进展的大 B 细胞淋巴瘤成人患者，把 CAR-T 从后期挽救治疗推进到二线治疗。", "summary": "该批准基于随机对照证据，标志 CAR-T 从晚期难治患者向更早治疗线扩展。", "sources": [ "SRC-358" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "二线获批改善治疗线位置，但生产速度、毒性管理和长期获益仍需真实世界验证。", "cross_links": [ "HIT-INS-049", "HIT-SCI-068" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T20:00:00Z", "updated_at": "2026-08-07T20:00:00Z" }, { "event_id": "HIT-POL-033", "title": "FDA 要求 CAR-T 产品增加 T 细胞恶性肿瘤黑框警告", "date_start": "2024-04-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "policy", "claim": "2024 年 4 月 18 日，FDA 要求 BCMA 或 CD19 靶向自体 CAR-T 免疫治疗产品增加 T 细胞恶性肿瘤黑框警告，回应真实世界中的继发性 T 细胞肿瘤报告。", "summary": "该监管行动把 CAR-T 的长期安全性从临床试验扩展到真实世界信号治理，成为细胞治疗成熟化的重要安全节点。", "sources": [ "SRC-359" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "黑框警告反映潜在严重风险，但继发性肿瘤的绝对发生率、因果机制和长期随访仍需进一步量化。", "cross_links": [ "HIT-INS-051", "HIT-INS-046", "HIT-INS-049" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T20:00:00Z", "updated_at": "2026-08-07T20:00:00Z" }, { "event_id": "HIT-INS-053", "title": "欧盟授权首个异染性脑白质营养不良基因疗法 Libmeldy", "date_start": "2020-12-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "European Union", "region": "Europe / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2020 年 12 月 21 日，Orchard Therapeutics 宣布欧盟授权 Libmeldy（atidarsagene autotemcel），用于早发型异染性脑白质营养不良，成为欧盟首个针对该疾病的基因疗法。", "summary": "Libmeldy 把自体造血干细胞基因修饰疗法引入罕见神经退行病监管，也暴露高价基因治疗的支付与可及性问题。", "sources": [ "SRC-360" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "欧盟授权基于单臂研究和自然史比较；长期疗效、成本效果和跨支付体系可及性仍需验证。", "cross_links": [ "HIT-INS-050", "HIT-INS-021" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用公司新闻稿 Wayback Machine 存档核验。", "created_at": "2026-08-07T21:00:00Z", "updated_at": "2026-08-07T21:00:00Z" }, { "event_id": "HIT-INS-054", "title": "FDA 批准 Breyanzi 并首次授予 RMAT 许可", "date_start": "2021-02-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2021 年 2 月 5 日，FDA 批准 lisocabtagene maraleucel（Breyanzi），用于复发或难治性大 B 细胞淋巴瘤成人患者，并成为首个获得 FDA 再生医学先进疗法（RMAT）指定后获批的产品。", "summary": "Breyanzi 扩展了 CD19 CAR-T 的可选产品，并把 RMAT 加速监管路径引入细胞治疗。", "sources": [ "SRC-361" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "批准基于关键试验应答数据，真实世界长期生存和安全性仍需随访。", "cross_links": [ "HIT-INS-049", "HIT-INS-046" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T21:00:00Z", "updated_at": "2026-08-07T21:00:00Z" }, { "event_id": "HIT-INS-055", "title": "FDA 批准第二个 BCMA 靶向 CAR-T 疗法 Carvykti", "date_start": "2022-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2022 年 2 月 28 日，FDA 批准 ciltacabtagene autoleucel（Carvykti），用于复发或难治性多发性骨髓瘤成人患者，成为第二个获批的 BCMA 靶向 CAR-T 细胞疗法。", "summary": "Carvykti 增加多发性骨髓瘤 CAR-T 治疗选择，并推动 BCMA 靶点从单产品走向竞争性监管格局。", "sources": [ "SRC-362" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "批准基于单臂关键试验，长期随访、细胞因子风暴和继发肿瘤风险仍需真实世界监测。", "cross_links": [ "HIT-INS-051", "HIT-POL-033" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T21:00:00Z", "updated_at": "2026-08-07T21:00:00Z" }, { "event_id": "HIT-INS-056", "title": "FDA 批准首个异染性脑白质营养不良基因疗法 Lenmeldy", "date_start": "2024-03-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2024 年 3 月 18 日，FDA 批准 atidarsagene autotemcel（Lenmeldy），用于儿童异染性脑白质营养不良，成为美国首个针对该疾病的基因疗法。", "summary": "Lenmeldy 把自体造血干细胞基因修饰疗法正式引入美国罕见神经退行病监管，并强化了单次高价基因治疗与长期自然史比较的证据范式。", "sources": [ "SRC-363" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "批准依赖单臂研究和自然史比较，样本量小，长期疗效、安全性和支付可持续性仍需验证。", "cross_links": [ "HIT-INS-053", "HIT-INS-050" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T21:00:00Z", "updated_at": "2026-08-07T21:00:00Z" }, { "event_id": "HIT-INS-057", "title": "FDA 批准首个实体瘤工程化细胞疗法 Tecelra", "date_start": "2024-08-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2024 年 8 月 2 日，FDA 加速批准 afamitresgene autoleucel（Tecelra），用于不可切除或转移性滑膜肉瘤成人患者，成为美国首个获批的实体瘤工程化细胞疗法和首个 TCR 基因疗法。", "summary": "Tecelra 把工程化细胞治疗从血液肿瘤扩展到实体瘤，标志 TCR-T 路线进入正式监管。", "sources": [ "SRC-364" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "该批准为加速批准路径，基于有限单臂队列；确证试验、长期疗效和实体瘤通用性仍待验证。", "cross_links": [ "HIT-INS-049", "HIT-INS-046" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 FDA Wayback Machine 存档核验。", "created_at": "2026-08-07T21:00:00Z", "updated_at": "2026-08-07T21:00:00Z" }, { "event_id": "HIT-INS-058", "title": "Human Longevity 成立", "date_start": "2013", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2013 年，J. Craig Venter、Robert Hariri 与 Peter H. Diamandis 在美国圣地亚哥成立 Human Longevity，目标是把人类基因组、表型组、影像与机器学习整合为健康寿命数据基础设施。", "summary": "Human Longevity 把个体基因组和表型数据规模化采集引入长寿产业，推动从科研样本到消费者健康寿命数据的商业基础设施形成。", "sources": [ "SRC-365" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "公司成立年份和融资规模来自 Wikipedia 转述，实际数据库规模、临床转化和商业可持续性仍需按年报与官方披露核验。", "cross_links": [ "HIT-INS-012", "HIT-INS-037", "HIT-INS-009" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T14:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-059", "title": "Life Biosciences 成立", "date_start": "2017", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2017 年，David Sinclair 等共同成立 Life Biosciences，总部位于波士顿，专注以表观遗传修复进行细胞年轻化和年龄相关疾病治疗。", "summary": "Life Biosciences 把部分表观遗传重编程从学术研究转向公司化平台，后来推动 ER-100 进入人体临床。", "sources": [ "SRC-366" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "创始人组合和成立年份来自 Wikipedia；公司技术平台、融资与临床推进需要按官方披露持续核验。", "cross_links": [ "HIT-TEC-014", "HIT-INS-058" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已做 Wikipedia 词条核验。", "created_at": "2026-08-06T14:10:00Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-INS-060", "title": "Longevity Vision Fund 成立", "date_start": "2019-02-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "New York / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2019 年 2 月 4 日，Sergey Young 与 Bold Capital Partners 等宣布成立 Longevity Vision Fund，初始规模 1 亿美元，专注投资延长健康寿命的早期技术与生命科学公司。", "summary": "Longevity Vision Fund 把长寿风险投资扩展为跨早期生物技术、AI 和健康基础设施的组合基金，标志产业资金网络进入规模化阶段。", "sources": [ "SRC-367" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "宣布规模为基金自述，实际出资、已投组合和回报表现需按监管文件与后续披露核验。", "cross_links": [ "HIT-INS-012", "HIT-INS-009", "HIT-INS-059" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 EurekAlert 官方新闻稿核验。", "created_at": "2026-08-06T14:10:00Z", "updated_at": "2026-08-06T14:10:00Z" }, { "event_id": "HIT-INS-061", "title": "Tally Health 完成 1000 万美元种子轮融资", "date_start": "2023-04-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2023 年 4 月 6 日，消费者长寿公司 Tally Health 宣布完成 1000 万美元种子轮，由 Forerunner Ventures 领投，多名公众人物参与。", "summary": "Tally Health 代表长寿产业向消费者端扩展：以生物年龄检测、干预建议和订阅式健康管理进入大众市场。", "sources": [ "SRC-368" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "融资规模来自公司新闻稿，产品效果、用户留存和生物年龄指标与临床终点的关系仍需独立验证。", "cross_links": [ "HIT-INS-058", "HIT-INS-060", "HIT-INS-041" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 PR Newswire 原始新闻稿核验。", "created_at": "2026-08-06T14:10:00Z", "updated_at": "2026-08-06T14:10:00Z" }, { "event_id": "HIT-INS-062", "title": "BioAge Labs 完成 1.98 亿美元 IPO", "date_start": "2024-09-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2024 年 9 月 26 日，BioAge Labs 宣布扩量 IPO 定价，按发行价计算总募资约 1.98 亿美元，成为衰老生物技术公司进入公开资本市场的节点。", "summary": "BioAge 上市显示市场开始为衰老相关生物技术平台提供公开股权资本，也把后续管线失败风险带入公开市场。", "sources": [ "SRC-369" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "IPO 募资额以发行时公告为准；后续股价、管线推进和临床证据需要独立核验，不构成投资建议。", "cross_links": [ "HIT-INS-012", "HIT-INS-040", "HIT-INS-041" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 BioSpace 公司新闻稿转载核验。", "created_at": "2026-08-06T14:10:00Z", "updated_at": "2026-08-06T14:10:00Z" }, { "event_id": "HIT-INS-063", "title": "Retro Biosciences 获得 1.8 亿美元早期融资", "date_start": "2023-03-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2023 年 3 月 8 日，MIT Technology Review 披露 OpenAI CEO Sam Altman 已向 Retro Biosciences 提供 1.8 亿美元早期投资，用于细胞重编程、自噬和血浆疗法以延长健康寿命。", "summary": "Retro 的融资把大型 AI 资本直接引入长寿生物技术，并为其与 OpenAI 的因子设计合作提供财务基础。", "sources": [ "SRC-370" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "投资金额和用途来自权威媒体披露，公司并未在当期发布完整融资公告；实际资金安排与研发转化需按后续披露核验。", "cross_links": [ "HIT-TEC-013", "HIT-INS-060" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 MIT Technology Review 报道核验。", "created_at": "2026-08-06T14:35:00Z", "updated_at": "2026-08-06T14:35:00Z" }, { "event_id": "HIT-INS-064", "title": "NewLimit 完成 1.3 亿美元 B 轮融资", "date_start": "2025-05-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2025 年 5 月 6 日，NewLimit 宣布完成 1.3 亿美元 B 轮融资，由 Kleiner Perkins 领投，用于扩展表观遗传重编程药物平台和 AI 驱动的规模化基因组学基础设施。", "summary": "NewLimit 的 B 轮融资把 AI 与表观遗传重编程组合成资本密集型的产业路线，后续继续获得大型药企和大学投资。", "sources": [ "SRC-371" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "融资规模来自公司官方博客；管线进度和临床时间表仍需按后续披露核验。", "cross_links": [ "HIT-INS-011", "HIT-INS-065" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 NewLimit 官方博客核验。", "created_at": "2026-08-06T14:35:00Z", "updated_at": "2026-08-06T14:35:00Z" }, { "event_id": "HIT-INS-065", "title": "NewLimit 以 16.2 亿美元估值上限完成 4500 万美元追加融资", "date_start": "2025-10-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2025 年 10 月 20 日，NewLimit 宣布在 16.2 亿美元估值上限下完成 4500 万美元追加融资，投资方包括 Eli Lilly、Duke Management Co、Section 32 等。", "summary": "该追加融资显示大型药企和大学资产进入表观遗传重编程赛道，并把 NewLimit 的 C 轮资本周期进一步拉长。", "sources": [ "SRC-372" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "估值上限和资金用途来自公司官方博客；后续 C 轮融资和临床推进需继续核验。", "cross_links": [ "HIT-INS-011", "HIT-INS-064" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 NewLimit 官方博客核验。", "created_at": "2026-08-06T14:35:00Z", "updated_at": "2026-08-06T14:35:00Z" }, { "event_id": "HIT-INS-066", "title": "Life Biosciences 完成 8000 万美元 D 轮融资", "date_start": "2026-04-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "social_composite", "event_type": "institution", "claim": "2026 年 4 月 8 日，Life Biosciences 宣布完成 8000 万美元 D 轮融资，用于推进 ER-100 Phase 1 临床试验和部分表观遗传重编程平台候选药物。", "summary": "Life Biosciences 的 D 轮融资支持其从 IND 阶段进入人体试验和管线扩展，强化 OSK 部分重编程路线的产业资金基础。", "sources": [ "SRC-373" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "融资完成和用途来自公司新闻稿；后续临床结果、资金消耗和候选药物推进需独立核验。", "cross_links": [ "HIT-TEC-014", "HIT-PRA-009", "HIT-INS-059" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 Life Biosciences 官方新闻稿核验。", "created_at": "2026-08-06T14:35:00Z", "updated_at": "2026-08-06T14:35:00Z" }, { "event_id": "HIT-PRA-013", "title": "BioAge 公布 BGE-102 阳性 Phase 1 中期数据", "date_start": "2025-12-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "maintenance", "event_type": "practice", "claim": "2025 年 12 月 4 日，BioAge Labs 公布 BGE-102 阳性 Phase 1 中期数据，显示口服 NLRP3 抑制剂可降低炎症标志物，并扩展肥胖伴高 hsCRP 人群的多次给药队列。", "summary": "BGE-102 的早期数据把慢性炎症作为年龄相关心血管风险的靶点推进到人体概念验证，也显示长寿生物技术公司转向代谢和心血管临床管线。", "sources": [ "SRC-374" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "中期数据来自单中心早期试验，样本有限；hsCRP 等标志物变化不等于心血管事件终点获益。", "cross_links": [ "HIT-INS-062", "HIT-PRA-014" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 BioAge 官方投资者新闻稿核验。", "created_at": "2026-08-06T14:35:00Z", "updated_at": "2026-08-06T14:35:00Z" }, { "event_id": "HIT-PRA-014", "title": "BioAge 启动 QUELL-CV Phase 2 并完成首例给药", "date_start": "2026-06-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "maintenance", "event_type": "practice", "claim": "2026 年 6 月 16 日，BioAge Labs 宣布 QUELL-CV Phase 2 概念验证试验完成首例给药，评估 BGE-102 三种口服剂量对高心血管风险人群 hsCRP 的影响。", "summary": "QUELL-CV 把 NLRP3 抑制从生物标志物阶段推进到剂量选择和 Phase 3 准备的随机对照阶段，是长寿产业转向代谢炎症临床验证的代表节点。", "sources": [ "SRC-375" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "首例给药不等于有效性结论；Phase 2 主要终点、长期安全和心血管事件获益仍需随机数据验证。", "cross_links": [ "HIT-INS-062", "HIT-PRA-013" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 BioAge 官方投资者新闻稿核验。", "created_at": "2026-08-06T14:35:00Z", "updated_at": "2026-08-06T14:35:00Z" }, { "event_id": "HIT-TEC-052", "title": "GNoME 报告大规模无机材料深度学习发现", "date_start": "2023-11-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / United States / Global", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2023 年 11 月 29 日，Google DeepMind 在 Nature 在线发表《Scaling deep learning for materials discovery》，报告 GNoME 发现约 220 万个候选晶体结构，其中约 38 万个被判定为稳定材料候选。", "summary": "GNoME 把材料搜索从人力试错转向大规模深度学习候选生成，成为 AI 自动化科学与材料数据库建设的重要节点。", "sources": [ "SRC-376" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "候选材料数量和稳定性判定来自计算模型，后续合成验证、实验稳定性和实际应用仍需要独立评估。", "cross_links": [ "HIT-TEC-053", "HIT-TEC-027" ], "chapter": "AI 自动化科学、技术与知识基础设施", "notes": "draft，等待来源语境复核。本轮已用 Nature DOI 元数据核验，日期取在线发表日。", "created_at": "2026-08-06T15:00:00Z", "updated_at": "2026-08-06T15:00:00Z" }, { "event_id": "HIT-TEC-053", "title": "A-Lab 自主实验室报告无机材料自动化合成", "date_start": "2023-11-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "North America / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2023 年 11 月 29 日，Nature 在线发表劳伦斯伯克利国家实验室 A-Lab 研究，报告 17 天内自主完成 355 次实验并成功合成 41 种预测无机材料；后续作者更正为 353 次实验和 36 个成功目标。", "summary": "A-Lab 把 AI 预测、机器人实验和闭环优化组合成自主材料实验室，标志科研从人工试错向全自动闭环推进。", "sources": [ "SRC-377" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "论文已发布作者更正，早期媒体对“新材料”的表述被弱化；自主合成成功率、通用性和长期可复现性仍需继续核验。", "cross_links": [ "HIT-TEC-052", "HIT-TEC-054" ], "chapter": "AI 自动化科学、技术与知识基础设施", "notes": "draft，等待来源语境复核。本轮已用 Nature DOI 元数据核验，日期取在线发表日。", "created_at": "2026-08-06T15:00:00Z", "updated_at": "2026-08-06T15:00:00Z" }, { "event_id": "HIT-TEC-054", "title": "RoboChem 报告自主光催化化学合成机器人", "date_start": "2024-01-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Netherlands", "region": "Europe / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2024 年 1 月 26 日，Science 发表阿姆斯特丹大学 RoboChem 研究，报告自主优化光催化流动化学、完成克级规模放大，并以更快速度和更高纯度合成药物相关分子。", "summary": "RoboChem 把化学合成转化为由机器人和 AI 驱动的闭环优化，显示自动化实验室从材料扩展到小分子药物合成。", "sources": [ "SRC-378" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "结果来自单平台示范，合成范围、量产规模、通用性和临床相关性仍需独立复现和扩展。", "cross_links": [ "HIT-TEC-053", "HIT-TEC-024" ], "chapter": "AI 自动化科学、技术与知识基础设施", "notes": "draft，等待来源语境复核。本轮已用 Crossref DOI 元数据核验。", "created_at": "2026-08-06T15:00:00Z", "updated_at": "2026-08-06T15:00:00Z" }, { "event_id": "HIT-TEC-055", "title": "AlphaFold 3 实现生物分子复合物统一结构预测", "date_start": "2024-05-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Global", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2024 年 5 月 8 日，Nature 在线发表 AlphaFold 3，报告统一预测蛋白质、核酸、小分子、离子和修饰残基复合物结构，并在蛋白-配体和抗体-抗原预测上显著提升精度。", "summary": "AlphaFold 3 把结构预测从蛋白质单体扩展到广泛生物分子空间，为药物设计、蛋白工程和分子医学提供统一计算接口。", "sources": [ "SRC-379" ], "evidence_grade": "S", "verification_status": "locally_reviewed", "status": "draft", "significance": "turning_point", "uncertainty": "模型性能来自论文基准，预测精度在不同靶点、动态构象和实验验证条件下仍有边界。", "cross_links": [ "HIT-TEC-025", "HIT-SCI-026" ], "chapter": "AI 自动化科学、技术与知识基础设施", "notes": "本地复核完成：来源 URL/DOI 可达，标题与事件主张匹配，证据等级和日期未发现过度推断；尚未独立 fresh review。", "created_at": "2026-08-06T15:00:00Z", "updated_at": "2026-08-06T15:00:00Z", "last_reviewed": "2026-08-07", "reviewer": "tradecatlabs" }, { "event_id": "HIT-TEC-056", "title": "Google 发布 AI co-scientist 科研协作系统", "date_start": "2025-02-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Global", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 2 月 19 日，Google Research 发布 AI co-scientist，基于 Gemini 2.0 的多智能体系统生成研究假设、方案和实验协议，并在药物重定位、肝纤维化靶点发现和抗菌素耐药机制三个生物医学任务中验证。", "summary": "AI co-scientist 把科研协作从检索和总结推进到假设生成、自动评审和实验方案建议，代表 AI 进入知识生产闭环的早期节点。", "sources": [ "SRC-380" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "系统输出仍需人工和实验验证，专家评估样本有限；自动生成假设不等于已被确证的科学结论。", "cross_links": [ "HIT-TEC-013", "HIT-TEC-024" ], "chapter": "AI 自动化科学、技术与知识基础设施", "notes": "draft，等待来源语境复核。本轮已用 Google Research 官方博客核验。", "created_at": "2026-08-06T15:00:00Z", "updated_at": "2026-08-06T15:00:00Z" }, { "event_id": "HIT-TEC-057", "title": "BrainGate 首次报告无线皮层内脑机接口居家使用", "date_start": "2021-06-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2021 年 6 月 17 日，Simeral 等人在 IEEE Transactions on Biomedical Engineering 在线发表 BrainGate 研究，报告两名四肢瘫痪参与者首次实现无线皮层内脑机接口的居家使用；其中一名参与者在居家环境中连续记录 24 小时皮层内信号，并可用无线系统控制商用平板电脑浏览网页和使用应用。", "summary": "该研究把皮层内 BCI 从实验室缆线束缚推进到居家自主使用，是脑机接口从研究装置走向日常辅助基础设施的关键节点。", "sources": [ "SRC-381" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "样本为两名参与者、单次代表性 24 小时记录；长期稳定性、居家部署规模和临床有效性仍需更大样本验证。", "cross_links": [ "HIT-TEC-032", "HIT-TEC-034" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 PubMed 元数据核验，日期取在线发表日。", "created_at": "2026-08-06T14:25:51Z", "updated_at": "2026-08-06T14:25:51Z" }, { "event_id": "HIT-TEC-058", "title": "Synchron 报告 COMMAND 试验完成首例美国受试者入组", "date_start": "2022-05-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Australia / United States", "region": "New York / North America", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2022 年 5 月 4 日，Synchron 宣布美国 COMMAND 早期可行性研究在纽约 Mount Sinai Hospital 完成首例受试者入组，受试者植入经血管 Stentrode 脑机接口；公司称该试验在 FDA 授予的永久植入 BCI 首个 IDE 下开展。", "summary": "COMMAND 首例入组标志经血管脑机接口首次进入美国人体研究，提供不打开颅骨接入脑信号的替代路径。", "sources": [ "SRC-382" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "公司新闻稿只确认首例入组；安全性、有效性、长期信号稳定性和推广性仍需监管和试验数据验证。", "cross_links": [ "HIT-TEC-032", "HIT-TEC-034" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Business Wire 官方新闻稿 Wayback Machine 存档核验。", "created_at": "2026-08-06T14:25:51Z", "updated_at": "2026-08-06T14:25:51Z" }, { "event_id": "HIT-TEC-059", "title": "Neuralink 披露 PRIME 研究第二名受试者完成植入", "date_start": "2024-08-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Arizona / North America", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2024 年 8 月 21 日，Neuralink 官方更新披露，PRIME 研究第二名受试者 Alex 已于上月接受 Link 植入，术后可玩电子游戏并使用 CAD 软件设计 3D 物件，且官方称未观察到该受试者的 thread retraction。", "summary": "该更新把高通道侵入式 BCI 从单例推进到多受试者阶段，并展示从基础光标控制到 CAD 和游戏等日常任务的应用。", "sources": [ "SRC-383" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "官方更新为公司与受试者披露，未提供完整临床安全性数据；植入约在 2024 年 7 月，实际日期未精确公开。", "cross_links": [ "HIT-TEC-034", "HIT-TEC-057" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Neuralink 官方更新页核验，日期取公告发布日期。", "created_at": "2026-08-06T14:25:51Z", "updated_at": "2026-08-06T14:25:51Z" }, { "event_id": "HIT-POL-034", "title": "FDA 授予 Neuralink Blindsight 突破性设备认定", "date_start": "2024-09-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "policy", "claim": "2024 年 9 月 17 日，Neuralink 宣布其 Blindsight 视觉假体获得 FDA Breakthrough Device Designation，面向视力损伤患者。", "summary": "突破性设备认定把视觉神经假体纳入加速监管通道，标志 BCI 从运动辅助扩展到感觉恢复和监管优先审评。", "sources": [ "SRC-384" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "突破性认定是监管状态，不代表设备已获批、已证明临床有效或已上市。", "cross_links": [ "HIT-TEC-033", "HIT-TEC-034" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Neuralink 官方公告核验。", "created_at": "2026-08-06T14:25:51Z", "updated_at": "2026-08-06T14:25:51Z" }, { "event_id": "HIT-TEC-060", "title": "Neuralink 启动加拿大 CAN-PRIME 国际试验", "date_start": "2024-11-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Canada / United States", "region": "North America / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2024 年 11 月 20 日，ClinicalTrials.gov 登记 Neuralink CAN-PRIME 早期可行性研究开始招募，评估机器人植入式脑机接口用于外部设备控制，标志 PRIME 人体试验从美国扩展到加拿大。", "summary": "CAN-PRIME 使高通道侵入式 BCI 进入国际多中心早期人体试验阶段，扩展受试人群和监管网络。", "sources": [ "SRC-385" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "登记开始日期来自 ClinicalTrials.gov；实际首例植入、完整招募和安全性结果需试验进展和独立报告确认。", "cross_links": [ "HIT-TEC-034", "HIT-TEC-059" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 ClinicalTrials.gov 试验注册核验。", "created_at": "2026-08-06T14:25:51Z", "updated_at": "2026-08-06T14:25:51Z" }, { "event_id": "HIT-TEC-061", "title": "Synchron 报告 COMMAND 试验 12 个月阳性结果", "date_start": "2024-09-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Australia", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2024 年 9 月 30 日，Synchron 宣布美国 COMMAND 研究 12 个月结果呈阳性：6 名严重双侧上肢瘫痪受试者全部完成入组并植入 Stentrode，均达到主要终点，未发生导致死亡或永久性功能恶化的器械相关严重不良事件，脑运动意图信号可稳定转换为数字动作输出。", "summary": "COMMAND 是 FDA 首个批准用于永久植入 BCI 的 IDE 试验，其 12 个月结果把经血管 BCI 从首例入组推进到多中心初步安全性与功能验证阶段。", "sources": [ "SRC-386" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "结果为公司披露并首次在神经外科会议报告，尚未以完整同行评审论文形式独立核验；样本仅 6 例，长期安全性和广泛适用性仍需更大研究。", "cross_links": [ "HIT-TEC-058", "HIT-TEC-034" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Business Wire 官方新闻稿 Wayback Machine 存档核验。", "created_at": "2026-08-06T14:32:13Z", "updated_at": "2026-08-06T14:32:13Z" }, { "event_id": "HIT-TEC-062", "title": "Synchron 首次用脑机接口控制 Apple Vision Pro", "date_start": "2024-07-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Australia", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2024 年 7 月 30 日，Synchron 宣布一名 64 岁 ALS 患者成为全球首个通过植入式脑机接口使用 Apple Vision Pro 的人，可直接用思维控制光标，完成纸牌游戏、观看 Apple TV 和发送短信。", "summary": "该演示把 BCI 从文本与光标控制扩展到空间计算界面，显示经血管脑机接口与消费级扩展现实生态结合的可能。", "sources": [ "SRC-387" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为单例使用演示，非正式临床试验结果；设备对个体效果、可重复性和商业可用性仍需验证。", "cross_links": [ "HIT-TEC-058", "HIT-TEC-061" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Business Wire 官方新闻稿 Wayback Machine 存档核验。", "created_at": "2026-08-06T14:32:13Z", "updated_at": "2026-08-06T14:32:13Z" }, { "event_id": "HIT-TEC-063", "title": "Neuralink 启动阿联酋 UAE-PRIME 试验", "date_start": "2025-05-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Arab Emirates / United States", "region": "Middle East / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 5 月 9 日，ClinicalTrials.gov 登记 Neuralink UAE-PRIME 可行性研究在阿联酋开始招募，评估机器人植入式脑机接口控制外部设备。", "summary": "UAE-PRIME 使 Neuralink PRIME 人体试验进入中东地区，标志国际多中心扩展的早期阶段。", "sources": [ "SRC-388" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "登记开始日期来自试验注册；实际植入、入组数量和结果尚未独立披露。", "cross_links": [ "HIT-TEC-060", "HIT-TEC-034" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 ClinicalTrials.gov 试验注册核验。", "created_at": "2026-08-06T14:32:13Z", "updated_at": "2026-08-06T14:32:13Z" }, { "event_id": "HIT-TEC-064", "title": "Neuralink 启动英国 GB-PRIME 试验", "date_start": "2025-07-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / United States", "region": "Europe / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 7 月 31 日，ClinicalTrials.gov 登记 Neuralink GB-PRIME 早期可行性研究在英国开始招募，评估机器人植入式脑机接口控制外部设备。", "summary": "GB-PRIME 把 PRIME 研究扩展到英国，显示高通道侵入式 BCI 正在进入欧洲监管和临床网络。", "sources": [ "SRC-389" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "登记开始日期来自试验注册；实际首例植入、招募进度和安全结果需后续证据。", "cross_links": [ "HIT-TEC-060", "HIT-TEC-063" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 ClinicalTrials.gov 试验注册核验。", "created_at": "2026-08-06T14:32:13Z", "updated_at": "2026-08-06T14:32:13Z" }, { "event_id": "HIT-TEC-065", "title": "Neuralink 启动 VOICE 沟通恢复试验", "date_start": "2025-10-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 10 月 3 日，ClinicalTrials.gov 登记 Neuralink VOICE 早期可行性研究在美国开始招募，评估机器人植入式脑机接口用于沟通恢复。", "summary": "VOICE 把 Neuralink 的临床目标从外部设备控制扩展到言语沟通恢复，是 BCI 面向失语和沟通障碍人群的功能方向扩展。", "sources": [ "SRC-390" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "登记开始日期来自试验注册；语音解码能力、安全性、沟通功能改善和可及性尚未有临床结果。", "cross_links": [ "HIT-TEC-059", "HIT-TEC-064" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 ClinicalTrials.gov 试验注册核验。", "created_at": "2026-08-06T14:32:13Z", "updated_at": "2026-08-06T14:32:13Z" }, { "event_id": "HIT-TEC-066", "title": "Neuralink 启动 CONVOY 辅助设备控制试验", "date_start": "2024-11-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2024 年 11 月 25 日，ClinicalTrials.gov 登记 Neuralink CONVOY 早期可行性研究在美国开始招募，评估通过脑机接口技术神经控制辅助设备。", "summary": "CONVOY 把 Neuralink 的临床范围从外部数字设备扩展到辅助设备控制，探索 BCI 对日常行动和护理支持的长期作用。", "sources": [ "SRC-391" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "登记开始日期来自试验注册；预计完成 2031-05-25，实际招募、设备类型和功能结果需后续证据。", "cross_links": [ "HIT-TEC-034", "HIT-TEC-065" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 ClinicalTrials.gov 试验注册核验。", "created_at": "2026-08-06T14:35:36Z", "updated_at": "2026-08-06T14:35:36Z" }, { "event_id": "HIT-TEC-067", "title": "Synchron 首次演示基于 Apple BCI HID 协议的思想控制 iPad", "date_start": "2025-08-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Australia", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 8 月 4 日，Synchron 发布首次公开演示：COMMAND 研究参与者 Mark 通过 Apple 新的 BCI Human Interface Device 协议，完全用思想控制 iPad，实现浏览主屏、打开应用和编写文本，无需手、语音或眼睛。", "summary": "Apple 把脑信号接入原生输入协议后，BCI 从厂商专用适配进入操作系统级集成，是脑机接口标准化和消费设备接入的重要节点。", "sources": [ "SRC-392" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "为单例公开演示，非正式临床试验结果；操作系统级接入的可用性、稳定性和普及范围仍需验证。", "cross_links": [ "HIT-TEC-062", "HIT-TEC-061" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Business Wire 官方新闻稿 Wayback Machine 存档核验。", "created_at": "2026-08-06T14:35:36Z", "updated_at": "2026-08-06T14:35:36Z" }, { "event_id": "HIT-INS-067", "title": "Synchron 完成 2 亿美元 D 轮融资", "date_start": "2025-11-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Australia", "region": "Global", "path_family": "cognitive_extension", "event_type": "institution", "claim": "2025 年 11 月 6 日，Synchron 宣布完成 2 亿美元 D 轮融资，由 Double Point Ventures 领投，累计融资达 3.45 亿美元，用于推进 Stentrode BCI 商业化、下一代界面和 AI 工程。", "summary": "该轮融资显示资本开始为经血管 BCI 的商业化、关键试验和 NeuroAI 平台建设提供规模化支持。", "sources": [ "SRC-393" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "融资规模和用途来自公司披露；商业化和长期临床成功仍需监管批准和疗效证据。", "cross_links": [ "HIT-TEC-061", "HIT-TEC-067" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Business Wire 官方新闻稿 Wayback Machine 存档核验。", "created_at": "2026-08-06T14:35:36Z", "updated_at": "2026-08-06T14:35:36Z" }, { "event_id": "HIT-TEC-068", "title": "Synchron 启动 INTENT 早期可行性研究", "date_start": "2026-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States / Australia", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "ClinicalTrials.gov 登记 Synchron INTENT 早期可行性研究预计于 2026 年 4 月开始在美国招募，评估经血管神经假体技术带来的独立性。", "summary": "INTENT 是 Synchron 下一代经血管 BCI 进入美国早期可行性阶段的节点，覆盖多个美国研究中心。", "sources": [ "SRC-394" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "开始日期为试验注册的预计日期；实际首例入组、设备规格和结果需后续证据。", "cross_links": [ "HIT-TEC-061", "HIT-INS-067" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 ClinicalTrials.gov 试验注册核验。", "created_at": "2026-08-06T14:35:36Z", "updated_at": "2026-08-06T14:35:36Z" }, { "event_id": "HIT-TEC-069", "title": "Synchron 启动澳大利亚 FOCUS-AUS 研究", "date_start": "2026-05-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Australia / United States", "region": "Australia / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 5 月 22 日，ClinicalTrials.gov 登记 Synchron FOCUS-AUS 研究在澳大利亚开始招募，评估经血管 BCI 的功能结果与控制能力。", "summary": "FOCUS-AUS 扩展 Synchron 在澳大利亚的功能结局研究，为多国注册与真实环境使用提供数据基础。", "sources": [ "SRC-395" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "登记开始日期来自试验注册；实际入组、功能改善和安全结果需后续证据。", "cross_links": [ "HIT-TEC-058", "HIT-INS-067" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 ClinicalTrials.gov 试验注册核验。", "created_at": "2026-08-06T14:35:36Z", "updated_at": "2026-08-06T14:35:36Z" }, { "event_id": "HIT-TEC-070", "title": "Intel 部署 Hala Point 大型神经形态系统", "date_start": "2024-04-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2024 年 4 月 17 日，Intel 宣布建成并部署 Hala Point，该大型神经形态研究系统包含 1,152 颗 Loihi 2 处理器、约 11.5 亿神经元和 1280 亿突触，用于探索更节能的脑启发 AI。", "summary": "Hala Point 把神经形态计算从芯片级推进到大型系统级研究平台，直接支撑脑启发智能和认知增强路线的算力基础设施探索。", "sources": [ "SRC-396" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "Intel 称为行业首个 11.5 亿神经元系统；具体性能、能效与长期研究价值需独立基准和后续评测。", "cross_links": [ "HIT-TEC-038" ], "chapter": "神经计算、记忆与数字迁移", "notes": "draft，等待来源语境复核。本轮已用 Intel Newsroom 归档稿核验。", "created_at": "2026-08-06T14:54:24Z", "updated_at": "2026-08-06T14:54:24Z" }, { "event_id": "HIT-TEC-071", "title": "FinalSpark 公开远程湿件计算平台", "date_start": "2024-05-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Switzerland / International", "region": "Global", "path_family": "digital_migration", "event_type": "technology", "claim": "2024 年 5 月 2 日，FinalSpark 团队在线发表 Neuroplatform 论文，提供开放、远程可访问的湿件计算平台，使研究者能以体外神经元培养开展学习与信息处理实验。", "summary": "Neuroplatform 把湿件计算从实验室演示推进到远程可复现研究基础设施，为生物计算和数字迁移路线提供新的实验入口。", "sources": [ "SRC-397" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "平台可远程访问不等于已验证通用计算能力；神经元培养的长期稳定性、标准化和伦理边界仍需后续研究。", "cross_links": [ "HIT-TEC-008" ], "chapter": "神经计算、记忆与数字迁移", "notes": "draft，等待来源语境复核。本轮已用 DOI/Crossref 元数据核验。", "created_at": "2026-08-06T14:54:24Z", "updated_at": "2026-08-06T14:54:24Z" }, { "event_id": "HIT-TEC-072", "title": "Cortical Labs 团队发表合成生物智能实验室构建方法", "date_start": "2025-04-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Australia / United States", "region": "Global", "path_family": "digital_migration", "event_type": "technology", "claim": "2025 年 4 月 23 日，Cortical Labs 与多机构团队在 Patterns 在线发表论文，提出从零建立合成生物智能实验室的方法，利用体外神经元进行目标导向任务训练。", "summary": "该论文将合成生物智能从原理演示推进为可操作的研究基础设施，与生物计算机路线共同扩展活性算力的工程化路径。", "sources": [ "SRC-398" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "论文是方法学与基础设施建议，不等同于已验证的通用智能或商业产品性能。", "cross_links": [ "HIT-TEC-008", "HIT-TEC-071" ], "chapter": "神经计算、记忆与数字迁移", "notes": "draft，等待来源语境复核。本轮已用 PubMed/DOI 元数据核验。", "created_at": "2026-08-06T14:54:24Z", "updated_at": "2026-08-06T14:54:24Z" }, { "event_id": "HIT-TEC-073", "title": "NYU Langone 完成全球首例全眼与部分面部联合移植", "date_start": "2023-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2023 年 5 月，NYU Langone 团队为一名 46 岁电击伤患者完成全球首例全眼与部分面部联合移植；同年 11 月 9 日公布，移植眼球显示持续血流和视网膜结构存活，但未恢复视知觉。", "summary": "全眼联合面部移植把复合组织重建推进到视觉器官层面，但视神经再生和视觉功能恢复仍是核心未解问题。", "sources": [ "SRC-399" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "官方新闻稿披露术后眼球血流与结构存活，不代表视觉功能恢复或长期存活；后续结果需独立随访。", "cross_links": [ "HIT-TEC-030" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 NYU Langone 官方新闻稿 Wayback Machine 归档核验。", "created_at": "2026-08-06T14:54:24Z", "updated_at": "2026-08-06T14:54:24Z" }, { "event_id": "HIT-SCI-074", "title": "首例人遗体多器官异种移植：六基因编辑猪全肝与双肾原位联合移植", "date_start": "2026-05-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "China / Global", "path_family": "reconstruction", "event_type": "practice", "claim": "2026 年 5 月 29 日，Med 在线发表研究，报告将六基因编辑猪的全肝和双肾原位联合移植入一名 53 岁人遗体受者，并持续监测近 5 天，未观察到超急性排斥。", "summary": "该遗体模型首次把异种移植从单器官推进到全肝加双肾多器官组合，为肝肾功能替代和未来桥接治疗提供系统级证据。", "sources": [ "SRC-400" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "遗体模型不等同于活体临床移植；近 5 天观察不能证明长期安全、生理调节或免疫耐受。", "cross_links": [ "HIT-TEC-009", "HIT-TEC-010", "HIT-SCI-021" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 PubMed/DOI 元数据核验。", "created_at": "2026-08-06T14:54:24Z", "updated_at": "2026-08-06T14:54:24Z" }, { "event_id": "HIT-SCI-075", "title": "MOMENTUM 3 五年结果支持磁悬浮心室辅助装置", "date_start": "2022-09-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / International", "region": "United States / Global", "path_family": "maintenance", "event_type": "technology", "claim": "2022 年 9 月 27 日，JAMA 在线发表 MOMENTUM 3 随机试验五年结局，比较全磁悬浮与轴流左心室辅助装置在晚期心衰患者中的长期生存与卒中风险。", "summary": "五年结局把机械循环支持证据从两年扩展至长期随访，是人工器官与生命维持路线的重要临床证据节点。", "sources": [ "SRC-401" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "五年随访仍受随机分组、交叉和患者选择影响，不能作为所有心衰患者的通用结论。", "cross_links": [ "HIT-SCI-065", "HIT-TEC-050" ], "chapter": "死亡判定与生命延续制度", "notes": "draft，等待来源语境复核。本轮已用 Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:05:00Z", "updated_at": "2026-08-06T15:05:00Z" }, { "event_id": "HIT-SCI-076", "title": "衰老生物标志物干预研究专家共识发表", "date_start": "2025-04-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "practice", "claim": "2025 年 4 月 7 日，Journal of Gerontology 发表 Delphi 专家共识，为人体衰老干预研究推荐 14 种生理、炎症、功能与认知生物标志物。", "summary": "该共识把衰老测量从研究工具推进为干预试验可采纳的标准，回应生物年龄指标跨研究可比性缺口。", "sources": [ "SRC-402" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "共识基于专家判断和特定受访群体，不替代独立验证、监管接受度或因果关系证据。", "cross_links": [ "HIT-SCI-019", "HIT-SCI-035", "HIT-SCI-036", "HIT-SCI-023" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:05:00Z", "updated_at": "2026-08-06T15:05:00Z" }, { "event_id": "HIT-SCI-077", "title": "17 种人类组织 DNA 甲基化衰老特征荟萃分析发表", "date_start": "2026-06-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "practice", "claim": "2026 年 6 月 26 日，Nature Aging 在线发表荟萃分析，基于 1.5 万余个人类甲基化图谱识别 17 种组织的保守与组织特异性衰老特征。", "summary": "该甲基化图谱为跨组织生物年龄测量和 NAD+ 等干预靶点提供系统级资源。", "sources": [ "SRC-403" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "荟萃分析整合公开队列，样本异质性和组织覆盖可能影响结论外推。", "cross_links": [ "HIT-SCI-009", "HIT-SCI-076" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:05:00Z", "updated_at": "2026-08-06T15:05:00Z" }, { "event_id": "HIT-SCI-078", "title": "十四种共识衰老生物标志物死亡率预测比较发表", "date_start": "2026-03-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Germany / International", "region": "Europe / Global", "path_family": "maintenance", "event_type": "practice", "claim": "2026 年 3 月 6 日，Biomarker Research 发表 BASE-II 队列研究，比较 14 种共识衰老生物标志物，发现表观遗传衰老速度 DunedinPACE 对死亡率的预测最强。", "summary": "该比较为生物年龄指标的选择提供跨标志物证据，指向表观遗传衰老速度在人体队列中的相对优势。", "sources": [ "SRC-404" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "BASE-II 以德国老年队列为主，预测优势需在更多人群和临床终点中复现。", "cross_links": [ "HIT-SCI-019", "HIT-SCI-076" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:05:00Z", "updated_at": "2026-08-06T15:05:00Z" }, { "event_id": "HIT-INS-068", "title": "NewLimit 披露首个候选药进入临床开发计划", "date_start": "2026-06-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "reconstruction", "event_type": "institution", "claim": "2026 年 6 月 9 日，NewLimit 在年度进度更新中披露首个候选药物已从 0 进入 1 个临床候选阶段，计划 2027 年开展首次人体研究。", "summary": "NewLimit 把表观遗传重编程从细胞发现推进到候选药物与临床前制造阶段，为长寿医学进入人体试验提供产业节点。", "sources": [ "SRC-405" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "公司披露的计划不等同于 IND 获批或人体疗效；首次人体研究、剂量和适应症仍需监管和临床证据。", "cross_links": [ "HIT-INS-011", "HIT-INS-064", "HIT-INS-065", "HIT-SCI-029" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 NewLimit 官方博客核验。", "created_at": "2026-08-06T15:05:00Z", "updated_at": "2026-08-06T15:05:00Z" }, { "event_id": "HIT-SCI-079", "title": "衰老生物标志物临床转化挑战与建议发表", "date_start": "2024-09-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "2024 年 9 月 16 日，Nature Aging 在线发表专家调查与建议，识别衰老生物标志物从临床前走向临床转化的六类关键障碍，并提出可行动、可及、稳健和可响应干预的验证建议。", "summary": "该建议把生物年龄测量与临床终点和监管讨论连接起来，回应生物标志物从科研工具到可采纳干预指标的缺口。", "sources": [ "SRC-406" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "建议基于专家调查与共识，不构成监管批准；各标志物的临床有效性仍需独立验证。", "cross_links": [ "HIT-SCI-023", "HIT-SCI-076" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:15:00Z", "updated_at": "2026-08-06T15:15:00Z" }, { "event_id": "HIT-SCI-080", "title": "第 12 届 ARDD 会议报告强调可行动衰老干预", "date_start": "2026-04-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Denmark / International", "region": "Europe / Global", "path_family": "maintenance", "event_type": "practice", "claim": "2026 年 4 月 6 日，Aging 在线发表第 12 届 ARDD 会议报告，综述衰老研究从描述性相关分析转向机制性、可工程化干预，并强调 AI 与临床前模型加速转化。", "summary": "ARDD 会议报告记录长寿科学界把健康寿命干预从机制发现推进到人体试验设计与转化管线的方向。", "sources": [ "SRC-407" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "会议报告汇总演讲与讨论，不代表具体干预已被证明有效。", "cross_links": [ "HIT-SCI-079", "HIT-INS-004" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:15:00Z", "updated_at": "2026-08-06T15:15:00Z" }, { "event_id": "HIT-SCI-081", "title": "首届全球老年物理学会议共识发表", "date_start": "2026-05-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Singapore / International", "region": "Global", "path_family": "maintenance", "event_type": "practice", "claim": "2026 年 5 月 14 日，Aging 在线发表首届全球老年物理学会议报告，汇集物理、生物、计算与医学研究者，提出共享多模态数据、物理化定义衰老/重编程/健康寿命、干预预测模型和跨物种转化四类优先事项。", "summary": "Gerophysics 把衰老研究推向可量化、可预测的物理与信息科学框架，为长寿干预建模提供学科基础设施。", "sources": [ "SRC-408" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "会议共识是研究议程，不等同于已验证理论或预测模型。", "cross_links": [ "HIT-SCI-079", "HIT-SCI-080" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:15:00Z", "updated_at": "2026-08-06T15:15:00Z" }, { "event_id": "HIT-SCI-082", "title": "Retro Biosciences 发表精确重编程评述", "date_start": "2025-06-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2025 年 6 月 9 日，Retro Biosciences 团队在 Cellular Reprogramming 在线发表评述，评估靶向 Cdkn2a 阳性细胞的 OSK 部分重编程在保留细胞身份前提下恢复衰老细胞功能并延长小鼠寿命的证据。", "summary": "该评述把重编程从全身性逆龄叙事收缩为可定位、可保留身份的精确重编程路线，为表观遗传重编程药物设计提供产业级视角。", "sources": [ "SRC-409" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "评述基于小鼠与人成纤维细胞证据，不代表人体疗效或已批准疗法。", "cross_links": [ "HIT-TEC-013", "HIT-SCI-029", "HIT-INS-063" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:15:00Z", "updated_at": "2026-08-06T15:15:00Z" }, { "event_id": "HIT-SCI-083", "title": "灵长类骨髓衰老图谱与维生素 C 干预研究发表", "date_start": "2026-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China / United States", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "2026 年 7 月 16 日，Cell Stem Cell 发表灵长类骨髓衰老单细胞图谱，显示长期口服维生素 C 可部分缓解共同淋巴祖细胞耗竭和髓系偏移，并对应约 4 年转录组年龄估计下降；研究含 Altos Labs 合作作者。", "summary": "该研究把衰老干预从模式动物推进到灵长类分子与祖细胞层面，为可测量、可干预的造血和免疫衰老提供系统证据。", "sources": [ "SRC-410" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "维生素 C 的效应基于灵长类模型和转录组/表观时钟估计，不等同于人体临床疗效。", "cross_links": [ "HIT-SCI-009", "HIT-SCI-019", "HIT-INS-005" ], "chapter": "老年科学、健康寿命与生物技术产业", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:15:00Z", "updated_at": "2026-08-06T15:15:00Z" }, { "event_id": "HIT-TEC-074", "title": "Synchron 启动加拿大 FOCUS-CAN 研究", "date_start": "2026-03-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Canada / United States", "region": "Canada / Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 3 月 18 日，ClinicalTrials.gov 登记 Synchron FOCUS-CAN 研究在加拿大开始招募，评估经血管 BCI 的功能结局与控制能力。", "summary": "FOCUS-CAN 延续 FOCUS-AUS 的多国功能结局路线，把 Synchron Stentrode 的证据基础扩展到北美研究网络。", "sources": [ "SRC-411" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "试验注册开始日期来自 ClinicalTrials.gov；实际入组、功能改善和安全结果需后续证据。", "cross_links": [ "HIT-TEC-069", "HIT-TEC-068" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 ClinicalTrials.gov 试验注册核验。", "created_at": "2026-08-06T15:25:00Z", "updated_at": "2026-08-06T15:25:00Z" }, { "event_id": "HIT-TEC-075", "title": "锁闭综合征患者意图言语解码研究发表", "date_start": "2026-03-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 3 月 30 日，Cell Reports 发表研究，报告从一名长期无言语、锁闭综合征且依赖呼吸机的 ALS 患者皮层内信号中解码音素、单词与高阶语言单元，准确率显著高于随机水平。", "summary": "该研究把言语 BCI 从保留发声能力的患者扩展到长期无言语的锁闭综合征场景，验证极端沟通障碍下的神经解码边界。", "sources": [ "SRC-412" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "句级解码准确率仍低于保留发声能力患者的演示；临床可用性、速度和泛化需进一步证据。", "cross_links": [ "HIT-TEC-065", "HIT-TEC-077" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:25:00Z", "updated_at": "2026-08-06T15:25:00Z" }, { "event_id": "HIT-TEC-076", "title": "瘫痪者双手快速打字神经假体研究发表", "date_start": "2026-03-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 3 月 16 日，Nature Neuroscience 发表研究，报告皮层内 BCI 打字神经假体让两名四肢瘫痪参与者通过尝试手指运动实现双键盘 QWERTY 打字，速度最高约 110 字符/分钟、词错误率 1.6%。", "summary": "双手打字神经假体把 BCI 从单点控制推进到高信息率、接近常人打字的通信范式。", "sources": [ "SRC-413" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "结果基于两名试验参与者，速度和错误率受语言模型、校准句数和个体差异影响。", "cross_links": [ "HIT-TEC-075", "HIT-TEC-057" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:25:00Z", "updated_at": "2026-08-06T15:25:00Z" }, { "event_id": "HIT-TEC-077", "title": "皮层内脑机接口长期独立家庭使用研究发表", "date_start": "2026-06-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 6 月 15 日，Nature Medicine 在线发表研究，报告一名因 ALS 瘫痪并伴严重构音障碍的男性近两年在家独立、近乎每日使用多模态 BCI 超过 3800 小时，无需研究者在场即可完成脑到文本言语与光标控制。", "summary": "该研究证明皮层内 BCI 从受控实验室演示走向长期、独立、高使用强度家庭场景，是认知外延路线的重要可用性节点。", "sources": [ "SRC-414" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为单例纵向研究；设备稳定性、通用性和长期安全仍需更多参与者与随访。", "cross_links": [ "HIT-TEC-075", "HIT-TEC-076", "HIT-TEC-057" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:25:00Z", "updated_at": "2026-08-06T15:25:00Z" }, { "event_id": "HIT-POL-035", "title": "FDA 授予 Neuralink 言语恢复项目突破性设备认定", "date_start": "2025-05-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "policy", "claim": "2025 年 5 月 1 日，Neuralink 宣布其面向严重言语障碍的脑机接口项目获得 FDA Breakthrough Device Designation，覆盖 ALS、卒中、脊髓损伤、脑瘫和多发性硬化等病因。", "summary": "言语恢复项目获得突破性设备认定，使 BCI 从数字设备控制扩展到沟通恢复监管路径。", "sources": [ "SRC-415" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "突破性设备认定不等于 FDA 批准；仍需临床安全性与有效性证据。", "cross_links": [ "HIT-POL-034", "HIT-TEC-065", "HIT-TEC-077" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Neuralink 官方更新页核验。", "created_at": "2026-08-06T15:25:00Z", "updated_at": "2026-08-06T15:25:00Z" }, { "event_id": "HIT-POL-036", "title": "加州将神经数据纳入敏感个人信息隐私法", "date_start": "2024-09-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "United States / Global", "path_family": "cognitive_extension", "event_type": "policy", "claim": "2024 年 9 月 28 日，加州州长签署 SB 1223，将神经数据作为敏感个人信息纳入加州隐私法，并于 2025 年 1 月 1 日生效。", "summary": "加州成为较早以州隐私法明确保护神经数据的司法辖区，为脑机接口数据治理提供法律边界。", "sources": [ "SRC-416" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "法律保护范围、执法和与医疗/科研数据制度的交叉仍需解释和后续监管。", "cross_links": [ "HIT-POL-016", "HIT-POL-034" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 California Legislative Information 官方法案历史核验。", "created_at": "2026-08-06T15:35:00Z", "updated_at": "2026-08-06T15:35:00Z" }, { "event_id": "HIT-INS-069", "title": "Neuralink 完成 6.5 亿美元 E 轮融资", "date_start": "2025-06-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "institution", "claim": "2025 年 6 月 2 日，Neuralink 宣布完成 6.5 亿美元 E 轮融资，投资方包括 ARK Invest、Founders Fund、Sequoia Capital 等，并披露五名严重瘫痪者正在使用其脑机接口控制数字与物理设备。", "summary": "E 轮融资支持多国临床试验、CONVOY 辅助设备、视觉与言语突破性项目及全脑接口研发。", "sources": [ "SRC-417" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "公司披露的里程碑为自身口径，融资不代表产品获批或临床成功。", "cross_links": [ "HIT-INS-067", "HIT-POL-034", "HIT-POL-035" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Neuralink 官方更新页核验。", "created_at": "2026-08-06T15:35:00Z", "updated_at": "2026-08-06T15:35:00Z" }, { "event_id": "HIT-TEC-078", "title": "Neuralink 披露三名 PRIME 参与者累计独立使用 Telepathy 近 5000 小时", "date_start": "2025-02-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 2 月 5 日，Neuralink 发布 A Year of Telepathy 更新，披露三名 PRIME 参与者累计植入超过 670 天、使用 Telepathy 超过 4900 小时，当月平均每日独立使用 6.5 小时。", "summary": "多人、长时间、独立使用的数据表明皮层内 BCI 从单例演示进入真实生活使用阶段。", "sources": [ "SRC-419" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为公司披露数据，非独立审计；参与者人数少且结果不代表安全性或疗效结论。", "cross_links": [ "HIT-TEC-059", "HIT-TEC-077" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Neuralink 官方更新页核验。", "created_at": "2026-08-06T15:35:00Z", "updated_at": "2026-08-06T15:35:00Z" }, { "event_id": "HIT-TEC-079", "title": "Neuralink 开源 datarepo 多模态数据目录", "date_start": "2025-06-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 6 月 22 日，Neuralink 发布并开源 datarepo catalog，用于管理神经信号、组织病理、制造、手术视频和脑影像等多模态数据。", "summary": "datarepo 把脑机接口研发数据从分散存储推进为可复现、可检索的开放目录，为 BCI 数据基础设施提供工程工具。", "sources": [ "SRC-420" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "开源的是 catalog 首组件，不是全部临床数据或验证结果。", "cross_links": [ "HIT-TEC-077" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Neuralink 官方更新页核验。", "created_at": "2026-08-06T15:35:00Z", "updated_at": "2026-08-06T15:35:00Z" }, { "event_id": "HIT-PRA-015", "title": "Synchron 发表经血管 BCI 十年临床转化主题演讲", "date_start": "2025-01-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Australia", "region": "Global", "path_family": "cognitive_extension", "event_type": "practice", "claim": "2025 年 1 月 27 日，Journal of Neural Engineering 发表 Synchron 在 BCI Society 会议的主题演讲，系统回顾经血管 Stentrode BCI 从概念到人体试验的十年临床转化路径。", "summary": "十年转化路径把经血管 BCI 的监管、工程、临床和患者使用经验整理为可审阅的行业知识。", "sources": [ "SRC-418" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "主题演讲代表公司视角，不等同于独立临床审查或产品获批。", "cross_links": [ "HIT-TEC-058", "HIT-TEC-061" ], "chapter": "认知外延、智能增强与数字身份", "notes": "draft，等待来源语境复核。本轮已用 Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:35:00Z", "updated_at": "2026-08-06T15:35:00Z" }, { "event_id": "HIT-SCI-084", "title": "《Nature Medicine》发表生物衰老时钟在健康与疾病中的系统综述", "date_start": "2026-07-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "2026 年 7 月 9 日，《Nature Medicine》在线发表 Wyss-Coray 与 Topol 的综述，系统评述生物衰老时钟在个体、器官、组织和细胞层面的测量进展，并讨论其在疾病风险识别、预防和健康寿命干预评估中的用途。", "summary": "该综述把表观遗传等生物时钟从研究标记推进为面向预防和健康寿命临床化的测量基础设施候选。", "sources": [ "SRC-421" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "综述观点不等同于已批准临床检验；生物时钟仍需跨人群验证和监管接受。", "cross_links": [ "HIT-SCI-019", "HIT-SCI-048", "HIT-SCI-075", "HIT-SCI-078" ], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:24:43Z", "updated_at": "2026-08-06T15:24:43Z" }, { "event_id": "HIT-SCI-085", "title": "《Current Opinion in Genetics & Development》综述重编程诱导年轻化", "date_start": "2026-05-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / United Kingdom", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "2026 年 5 月 20 日，《Current Opinion in Genetics & Development》在线发表 Mayo Clinic 团队综述，把重编程诱导年轻化定义为短暂进入早期重编程状态而无需完全去分化，并评述 mRNA 递送、CRISPRa、化学鸡尾酒和组织特异性应用。", "summary": "该综述把部分重编程从单一 Yamanaka 因子范式扩展为多种递送与筛选平台，同时明确其临床转化仍受安全窗口限制。", "sources": [ "SRC-422" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "综述覆盖临床前机制与平台进展，不构成人体疗效结论。", "cross_links": [ "HIT-SCI-082", "HIT-SCI-086", "HIT-TEC-013", "HIT-TEC-014" ], "chapter": "细胞重编程、表观遗传年轻化与再生医学", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:24:43Z", "updated_at": "2026-08-06T15:24:43Z" }, { "event_id": "HIT-SCI-086", "title": "瞬时重编程首次报告内皮细胞功能年轻化", "date_start": "2026-06-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Germany", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2026 年 6 月 26 日，《Basic Research in Cardiology》在线发表原始研究，报告非基因性短暂表达 Yamanaka 因子可在体外降低衰老内皮细胞的 p16INK4a 与 p14ARF 等衰老标志，并在小鼠后肢缺血模型中改善血管功能。", "summary": "该研究把部分重编程从成纤维细胞扩展到内皮细胞，为心血管衰老修复提供概念证据。", "sources": [ "SRC-423" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为细胞与小鼠概念验证，非人体治疗结果；机制和长期安全性仍需独立验证。", "cross_links": [ "HIT-SCI-085", "HIT-SCI-083" ], "chapter": "细胞重编程、表观遗传年轻化与再生医学", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:24:43Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-087", "title": "《Cell Reports Medicine》综述基因治疗干预衰老", "date_start": "2026-06-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "2026 年 6 月 15 日，《Cell Reports Medicine》在线发表中国科学院动物研究所团队综述，系统整合基因编辑、RNA 调控和表观遗传重编程等基因治疗技术用于调节衰老相关通路。", "summary": "该综述把衰老干预从单靶点策略扩展到基因治疗框架，强调其对衰老轨迹重塑的可能性和临床转化约束。", "sources": [ "SRC-424" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "综述基于现有基因治疗与衰老生物学证据，不构成具体人体延寿疗效证明。", "cross_links": [ "HIT-SCI-085", "HIT-INS-016", "HIT-INS-021" ], "chapter": "细胞重编程、表观遗传年轻化与再生医学", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:24:43Z", "updated_at": "2026-08-06T15:24:43Z" }, { "event_id": "HIT-THT-082", "title": "《Communications Medicine》提出植入式脑机接口数据保护框架", "date_start": "2026-07-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Germany", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "2026 年 7 月 27 日，《Communications Medicine》发表综述，指出现有 HIPAA/GDPR 不足以充分保护临床植入式 BCI 的高分辨率神经信号，并识别去标识依赖、个体控制、同意、滥用护栏和所有权五类缺口。", "summary": "该综述把植入式 BCI 数据保护从通用隐私法扩展到神经数据权利、同意分离和货币化护栏，为 BCI 临床化的治理基础设施提供框架。", "sources": [ "SRC-425" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为政策分析综述，不是立法或监管生效事件。", "cross_links": [ "HIT-POL-036", "HIT-THT-072", "HIT-TEC-077" ], "chapter": "脑机接口、神经数据与主体边界", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:24:43Z", "updated_at": "2026-08-06T15:24:43Z" }, { "event_id": "HIT-SCI-088", "title": "《Transplantation》发表器官再调节临床与伦理观点文章", "date_start": "2026-06-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Italy", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "2026 年 6 月 26 日，《Transplantation》在线发表观点文章，提出机器灌注时代的器官再调节正在从“保藏”走向“修复”，并讨论其临床可及性、分配公平和伦理治理含义。", "summary": "器官再调节把保存路径从延长可移植窗口推进到主动修复器官功能，为暂停与重建之间提供概念桥梁。", "sources": [ "SRC-426" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "观点文章不代表临床指南或已被验证的修复疗效。", "cross_links": [ "HIT-TEC-020", "HIT-SCI-074" ], "chapter": "器官保存、机器灌注与异种移植", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:28:25Z", "updated_at": "2026-08-06T15:28:25Z" }, { "event_id": "HIT-SCI-089", "title": "机器灌注实体器官移植经济学范围综述发表", "date_start": "2026-06-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Netherlands", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "2026 年 6 月 25 日，《Transplantation》在线发表范围综述，纳入 43 项研究，发现机器灌注的收益可延伸到等待名单死亡、移植后成本和物流，但经济评估中结局纳入不一致，且没有研究采用全社会视角。", "summary": "该综述把机器灌注从单器官结局问题扩展为卫生技术评估问题，暴露成本价值证据尚未成熟。", "sources": [ "SRC-427" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "范围综述基于现有经济评估，不直接证明某种灌注模式更具成本效果。", "cross_links": [ "HIT-SCI-088", "HIT-TEC-020" ], "chapter": "器官保存、机器灌注与异种移植", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:28:25Z", "updated_at": "2026-08-06T15:28:25Z" }, { "event_id": "HIT-SCI-090", "title": "美国肝移植低温与常温机器灌注队列研究发表", "date_start": "2026-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2026 年 7 月 16 日，《Journal of the American College of Surgeons》在线发表基于 OPTN 2016-2024 数据的美国队列研究，纳入低温机器灌注 235 例与常温机器灌注 3897 例，并报告机器灌注使用量在 2019 至 2024 年间显著增长。", "summary": "该研究把两种主流机器灌注模式从单中心经验推向全国注册数据比较，为肝移植选择提供真实世界证据。", "sources": [ "SRC-428" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为观察性队列，可能存在选择偏倚；全文结局与置信区间需在本地复核中继续检查。", "cross_links": [ "HIT-TEC-020", "HIT-SCI-088" ], "chapter": "器官保存、机器灌注与异种移植", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:28:25Z", "updated_at": "2026-08-06T15:28:25Z" }, { "event_id": "HIT-SCI-091", "title": "《Transplantation》综述从基因编辑到外源化猪源免疫相容器官", "date_start": "2026-08-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Germany / United States / Japan", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "2026 年 8 月 4 日，《Transplantation》在线发表多国团队综述，系统梳理从猪基因编辑到“外源化”免疫相容器官的技术路线，并讨论其作为移植供体来源的临床转化前景。", "summary": "该综述把异种移植从单点基因编辑扩展为可工程化器官供应链，连接基因编辑、免疫相容和器官移植基础设施。", "sources": [ "SRC-429" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "综述观点不等同于异种器官已获批或已证明长期安全有效。", "cross_links": [ "HIT-SCI-074", "HIT-TEC-020" ], "chapter": "器官保存、机器灌注与异种移植", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:28:25Z", "updated_at": "2026-08-06T15:28:25Z" }, { "event_id": "HIT-SCI-092", "title": "儿科供肝常温机器灌注单中心病例系列发表", "date_start": "2026-04-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "reconstruction", "event_type": "practice", "claim": "2026 年 4 月 7 日，《American Journal of Transplantation》在线发表单中心回顾病例系列，报告 14 例体重低于 35 kg 的儿科供肝使用改良常温机器灌注，其中 9 例来自循环死亡捐献，12 例达到机构活力标准并用于移植。", "summary": "儿科常温机器灌注扩展了低体重供肝和 DCD 供肝的使用边界，是把成人器官保存技术迁移到儿童移植路径的早期临床证据。", "sources": [ "SRC-430" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "单中心、小样本回顾系列，不等同于多中心疗效结论。", "cross_links": [ "HIT-SCI-090", "HIT-SCI-088" ], "chapter": "器官保存、机器灌注与异种移植", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:28:25Z", "updated_at": "2026-08-06T15:28:25Z" }, { "event_id": "HIT-THT-083", "title": "AI 驱动药物合成整合 LLM、机器人自动化与可持续指标", "date_start": "2026-06-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "India / Italy", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "2026 年 6 月 17 日，《Medicinal Research Reviews》在线发表综述，提出 AI 正在把药物合成从任务型预测器整合为逆合成、反应优化和闭环机器人自动化统一平台，并强调步骤数、时间到体外实验和绿色指标等可复现基准。", "summary": "该综述把 AI 合成化学从单点工具推进为可衡量、可自动化的药物发现基础设施。", "sources": [ "SRC-431" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "综述基于现有平台与文献，不证明任何特定管线已实现临床收益。", "cross_links": [ "HIT-TEC-056", "HIT-TEC-024" ], "chapter": "AI 自动化科研与药物发现", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:30:39Z", "updated_at": "2026-08-06T15:30:39Z" }, { "event_id": "HIT-SCI-093", "title": "TeLLAgent 提出双代理科研发现框架", "date_start": "2026-05-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 5 月 22 日，《Chemical Science》发表 TeLLAgent 论文，提出 supervisor-executor 双代理框架，由全局规划代理执行迭代推理并动态制定计划，由局部执行代理调用工具增强 LLM 完成复杂科研任务。", "summary": "TeLLAgent 把策略推理与工具执行分离，是缓解 LLM 科研代理幻觉和逻辑不一致的一种工程路径。", "sources": [ "SRC-432" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为论文提出的代理框架，结果依赖特定模型、工具集和评测任务，不代表通用科研自动化成熟。", "cross_links": [ "HIT-TEC-056", "HIT-THT-083" ], "chapter": "AI 自动化科研与药物发现", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:30:39Z", "updated_at": "2026-08-06T15:30:39Z" }, { "event_id": "HIT-THT-084", "title": "自驱动扫描探针显微镜综述发表", "date_start": "2026-07-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "2026 年 7 月 14 日，《Accounts of Chemical Research》在线发表综述，提出扫描探针显微镜正从操作员逐步驱动的离散工作流转向自主数据采集、实时解释和实验决策闭环。", "summary": "自驱动扫描探针显微镜把纳米尺度观测基础设施推进为闭环科研工具，降低人工逐点操作瓶颈。", "sources": [ "SRC-433" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为技术综述，不等同于已大规模部署或已证明跨实验室通用。", "cross_links": [ "HIT-THT-085", "HIT-THT-083" ], "chapter": "AI 自动化科研与药物发现", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:30:39Z", "updated_at": "2026-08-06T15:30:39Z" }, { "event_id": "HIT-THT-085", "title": "《Nature Reviews Chemistry》综述自驱动实验室演进", "date_start": "2026-07-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "2026 年 7 月 31 日，《Nature Reviews Chemistry》在线发表综述，指出自驱动实验室在过去十年从窄用途自动化工具发展为算法提出、执行并解释实验的多用途发现平台，下一阶段需满足可扩展性、可泛化性和完整来源实验记录。", "summary": "该综述把自驱动实验室从实验自动化叙事转向共享科研基础设施的建设约束，强调可复现性和来源治理。", "sources": [ "SRC-434" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为领域展望，不代表已形成通用集体科学超智能。", "cross_links": [ "HIT-SCI-093", "HIT-THT-084" ], "chapter": "AI 自动化科研与药物发现", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:30:39Z", "updated_at": "2026-08-06T15:30:39Z" }, { "event_id": "HIT-THT-086", "title": "Pfizer 团队综述代理式 AI 是否可能扭转 Eroom 定律", "date_start": "2026-08-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "2026 年 8 月 4 日，《Drug Discovery Today》在线发表 Pfizer 团队综述，讨论大型推理模型驱动的代理式 AI 在药物研发全流程中的应用潜力，并指出算法药物重定位等近期用例可能缓解 Eroom 定律。", "summary": "该综述把代理式 AI 从单点预测模型扩展到目标发现、临床开发与上市后监测的连续研发基础设施。", "sources": [ "SRC-435" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为公司团队综述和潜力分析，不是已确证的生产力改善结果。", "cross_links": [ "HIT-THT-083", "HIT-TEC-024", "HIT-TEC-056" ], "chapter": "AI 自动化科研与药物发现", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:30:39Z", "updated_at": "2026-08-06T15:30:39Z" }, { "event_id": "HIT-THT-087", "title": "AI 视角综述冷冻保护剂设计借鉴药物发现", "date_start": "2026-06-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Canada / United States / China / UAE", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "2026 年 6 月 11 日，《Advanced Science》在线发表综述，提出把药物发现的优化与安全性逻辑迁移到冷冻保护剂设计，并用 AI 导向方法解决细胞、组织和器官低温保存中的规模化瓶颈。", "summary": "该综述把低温保存从经验配方推进为可设计、可优化、可筛选的分子工程问题。", "sources": [ "SRC-436" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为 AI 导向观点综述，不等同于已有可用于人体器官保存的新型冷冻保护剂。", "cross_links": [ "HIT-TEC-019", "HIT-TEC-021" ], "chapter": "低温保存、生物停滞与未来选择权", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:32:31Z", "updated_at": "2026-08-06T15:32:31Z" }, { "event_id": "HIT-THT-088", "title": "组织与器官低温保存制冷剂选择指南发表", "date_start": "2026-06-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "2026 年 6 月 3 日，《Cryobiology》在线发表制冷剂选择指南，指出液氮仍是标准制冷剂，但其冷却速率和人体尺度断裂风险促使研究者寻找可定制相变温度、更快冷却并减少热应力的替代制冷剂。", "summary": "该指南把低温保存的基础设施约束显式化，为组织与器官保存的工程尺度扩展提供材料选择框架。", "sources": [ "SRC-437" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为工程指南与材料分析，不是器官保存成功结果。", "cross_links": [ "HIT-TEC-019", "HIT-THT-087" ], "chapter": "低温保存、生物停滞与未来选择权", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:32:31Z", "updated_at": "2026-08-06T15:32:31Z" }, { "event_id": "HIT-THT-089", "title": "综述电场体积加热用于玻璃化组织复温", "date_start": "2026-04-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "2026 年 4 月 2 日，《Cryobiology》在线发表综述，比较磁纳米颗粒 nanowarming 与交变电场介电加热两种玻璃化组织体积复温路径，并讨论更快、更均匀复温对减少冰晶和冷冻保护剂毒性的作用。", "summary": "体积复温把玻璃化保存从小型样本扩展到器官尺度的关键工程环节，是生物停滞路径的重要组成部分。", "sources": [ "SRC-438" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "综述基于现有实验技术，不构成人体器官长期保存已可行。", "cross_links": [ "HIT-TEC-019", "HIT-THT-088" ], "chapter": "低温保存、生物停滞与未来选择权", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:32:31Z", "updated_at": "2026-08-06T15:32:31Z" }, { "event_id": "HIT-THT-090", "title": "全卵巢低温保存与移植叙事综述发表", "date_start": "2026-05-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "2026 年 5 月 15 日，《Journal of Assisted Reproduction and Genetics》在线发表叙事综述，讨论全卵巢低温保存与移植通过保留血管蒂和直接微血管吻合减少卵泡损失，以恢复生育与长期激素功能。", "summary": "全卵巢保存把低温保存从生殖细胞和卵巢组织扩展到带血管蒂的完整器官，为生育和内分泌未来选择权提供潜在路径。", "sources": [ "SRC-439" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为临床前与早期临床转化综述，不等同于全卵巢保存已常规可行。", "cross_links": [ "HIT-SCI-064", "HIT-TEC-019" ], "chapter": "低温保存、生物停滞与未来选择权", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:32:31Z", "updated_at": "2026-08-06T15:32:31Z" }, { "event_id": "HIT-SCI-094", "title": "CryoClean 封闭玻璃化胚胎保存系统发表", "date_start": "2026-05-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China / Thailand / Cambodia", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "2026 年 5 月 9 日，《Cryobiology》在线发表技术论文，报告 CryoClean 封闭式玻璃化系统旨在同时提高胚胎保存效率和无菌性。", "summary": "CryoClean 把胚胎玻璃化从开放操作推进为封闭系统，是生殖未来选择权基础设施的一个工程节点。", "sources": [ "SRC-440" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为特定系统技术报告，不等同于多中心临床标准或长期妊娠结局结论。", "cross_links": [ "HIT-SCI-064", "HIT-THT-090" ], "chapter": "低温保存、生物停滞与未来选择权", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:32:31Z", "updated_at": "2026-08-06T15:32:31Z" }, { "event_id": "HIT-SCI-095", "title": "《Nature Aging》提出老年医学试验分层终点与胜率统计", "date_start": "2026-06-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Austria / France", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "2026 年 6 月 24 日，《Nature Aging》在线发表方法文章，提出用分层终点和胜率统计捕捉老年保护干预的多维效应，以弥合死亡终点难用与健康寿命替代终点未充分验证之间的鸿沟。", "summary": "该方法把老年医学试验从单一终点转向多维临床结局，为长寿干预建立更可操作的临床试验统计框架。", "sources": [ "SRC-441" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为统计方法建议，不等同于监管已接受该终点体系。", "cross_links": [ "HIT-THT-029", "HIT-PRA-014" ], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:34:16Z", "updated_at": "2026-08-06T15:34:16Z" }, { "event_id": "HIT-SCI-096", "title": "laromestrocel 治疗衰老虚弱完成随机 2b 期剂量递增试验", "date_start": "2026-02-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Japan", "region": "Global", "path_family": "maintenance", "event_type": "practice", "claim": "2026 年 2 月 25 日，《Cell Stem Cell》在线发表 Longeveron 等开展的随机 2b 期剂量递增试验，评估干细胞候选药 laromestrocel 对衰老虚弱的治疗潜力。", "summary": "该试验把衰老虚弱相关细胞疗法推进到随机剂量递增阶段，是长寿干预从概念走向人体临床试验的证据节点。", "sources": [ "SRC-442" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为随机试验发表，不构成监管批准或已确证疗效；结果需全文和独立复核。", "cross_links": [ "HIT-THT-029", "HIT-SCI-095" ], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:34:16Z", "updated_at": "2026-08-06T15:34:16Z" }, { "event_id": "HIT-THT-091", "title": "长寿药理学临床转化进展综述发表", "date_start": "2026-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Italy", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "2026 年 7 月 16 日，《Expert Opinion on Investigational Drugs》在线发表叙述综述，评述长寿药理学从描述性老年学走向机制驱动领域，并评估衰老生物学、自噬、代谢通路、干细胞策略和 AI 生物标志物开发是否真正进入临床进展。", "summary": "该综述对长寿药物研发保持审慎，强调早期临床信号与真实临床结局之间仍有距离。", "sources": [ "SRC-443" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为作者视角综述，不是系统评价或临床指南。", "cross_links": [ "HIT-SCI-095", "HIT-PRA-014" ], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:34:16Z", "updated_at": "2026-08-06T15:34:16Z" }, { "event_id": "HIT-THT-092", "title": "Einstein Circle 提出数字健康长寿政策议程", "date_start": "2026-06-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Germany / Switzerland / United States", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "2026 年 6 月 30 日，《Ageing Research Reviews》在线发表 Einstein Circle 政策议程文章，提出用包容、数据驱动的数字技术支持健康长寿社会建设。", "summary": "该政策议程把数字健康技术从个体工具上升为老龄化社会的公共基础设施与治理对象。", "sources": [ "SRC-444" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为政策议程建议，不等同于已生效国家或国际政策。", "cross_links": [ "HIT-THT-093", "HIT-POL-016" ], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:34:16Z", "updated_at": "2026-08-06T15:34:16Z" }, { "event_id": "HIT-THT-093", "title": "欧盟健康老龄化与长寿研究支持计划呼吁发表", "date_start": "2026-05-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "European Union", "region": "Europe", "path_family": "social_composite", "event_type": "thought", "claim": "2026 年 5 月 3 日，《Mechanisms of Ageing and Development》在线发表多作者政策呼吁，提出建立欧盟健康老龄化与长寿协调支持计划，以增强相关研究的资金、协调与转化基础设施。", "summary": "该呼吁把长寿研究视为欧盟科研基础设施缺口，而非单一学科议题。", "sources": [ "SRC-445" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为政策呼吁，不是欧盟已批准资助计划。", "cross_links": [ "HIT-THT-092", "HIT-INS-009" ], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:34:16Z", "updated_at": "2026-08-06T15:34:16Z" }, { "event_id": "HIT-THT-094", "title": "脑机接口具身化如何削弱持续知情同意论文发表", "date_start": "2026-06-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "2026 年 6 月 23 日，《BMC Medical Ethics》在线发表规范分析，讨论长期侵入式 BCI 用户因功能依赖和现象学身体整合，可能削弱最初同意取出的持续道德效力。", "summary": "该论文把 BCI 知情同意从一次性授权改为随具身化而动态变化的持续道德问题。", "sources": [ "SRC-446" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为规范分析，不是监管标准或临床指南。", "cross_links": [ "HIT-THT-082", "HIT-TEC-077" ], "chapter": "认知增强、记忆编辑与神经权利", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:41:34Z", "updated_at": "2026-08-06T15:41:34Z" }, { "event_id": "HIT-THT-095", "title": "神经技术负责任创新伦理治理策略范围综述发表", "date_start": "2025-11-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Australia / Germany", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "2025 年 11 月 11 日，《Journal of Bioethical Inquiry》在线发表范围综述，梳理学术、政府、多边组织和产业界提出的神经技术伦理治理指南。", "summary": "该综述把分散的神经伦理倡议整理为可比较的治理策略，为神经权利和 BCI 监管提供证据基础。", "sources": [ "SRC-447" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为指南范围综述，不替代具体国家立法或监管。", "cross_links": [ "HIT-POL-016", "HIT-THT-072" ], "chapter": "认知增强、记忆编辑与神经权利", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:41:34Z", "updated_at": "2026-08-06T15:41:34Z" }, { "event_id": "HIT-THT-096", "title": "植入式医疗设备伦理议题分析发表", "date_start": "2026-07-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Brazil", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "2026 年 7 月 7 日，《Brazilian Journal of Psychiatry》在线发表叙事与规范分析，讨论植入式医疗设备在持续监测、自主治疗和脆弱人群中的知情同意、数据治理与神经权利问题。", "summary": "该分析把植入设备从临床工具扩展为持续介入主体生活与自主权的治理对象。", "sources": [ "SRC-448" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为伦理分析，不是临床或监管结论。", "cross_links": [ "HIT-THT-094", "HIT-THT-095" ], "chapter": "认知增强、记忆编辑与神经权利", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:41:34Z", "updated_at": "2026-08-06T15:41:34Z" }, { "event_id": "HIT-SCI-097", "title": "老年人经颅电刺激与认知训练随机对照试验发表", "date_start": "2026-07-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Germany", "region": "Global", "path_family": "maintenance", "event_type": "practice", "claim": "2026 年 7 月 14 日，《Journal of NeuroEngineering and Rehabilitation》发表三盲随机假刺激对照试验，研究重复经颅电刺激联合任务训练对老年人认知耦合与衰退延缓的作用。", "summary": "该试验把非药物认知增强从概念推进到老年人随机对照证据，为认知基础设施提供可验证干预路径。", "sources": [ "SRC-449" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为单次随机试验，结果需全文和独立复核，不代表普适疗效。", "cross_links": [ "HIT-SCI-098", "HIT-THT-094" ], "chapter": "认知增强、记忆编辑与神经权利", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:41:34Z", "updated_at": "2026-08-06T15:41:34Z" }, { "event_id": "HIT-SCI-098", "title": "长期动作视频游戏训练注意力增强 EEG 研究发表", "date_start": "2026-04-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "cognitive_extension", "event_type": "practice", "claim": "2026 年 4 月 13 日，《International Journal of Psychophysiology》在线发表研究，使用多尺度 EEG 证据报告长期动作视频游戏训练后的注意力增强。", "summary": "该研究把可训练注意力作为通用认知资源，为注意力和执行功能提升提供非药物证据路径。", "sources": [ "SRC-450" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为训练效应研究，不等同于通用认知增强或临床治疗方案。", "cross_links": [ "HIT-SCI-097", "HIT-THT-094" ], "chapter": "认知增强、记忆编辑与神经权利", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:41:34Z", "updated_at": "2026-08-06T15:41:34Z" }, { "event_id": "HIT-INS-070", "title": "Retro Biosciences 完成初始融资并达 18 亿美元投前估值", "date_start": "2026-05-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "2026 年 5 月 22 日，Retro Biosciences 官方博客公布下一轮融资初始完成，投前估值 1.8 亿美元由 4P Capital 领投，并称公司在三年内从首个实验室推进到临床候选药。", "summary": "该融资把 Retro 从早期研究平台推进为具备临床候选药的衰老生物学转化公司，是长寿产业资本扩张的重要节点。", "sources": [ "SRC-451" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为官方披露的初始完成金额，未公布最终总额与完整投资方清单。", "cross_links": [ "HIT-INS-063", "HIT-PRA-016" ], "chapter": "长寿产业资金、联邦资助与健康寿命转化", "notes": "draft，等待来源语境复核。本轮已用 Retro 官方博客核验。", "created_at": "2026-08-06T15:49:36Z", "updated_at": "2026-08-06T15:49:36Z" }, { "event_id": "HIT-PRA-016", "title": "Retro 披露 RTR242 进入 Phase 1 并完成首次人体给药", "date_start": "2026-05-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / Australia", "region": "Global", "path_family": "maintenance", "event_type": "practice", "claim": "2026 年 5 月 22 日，Retro Biosciences 官方博客披露 RTR242 已进入 Phase 1 临床试验，并称其在 15 个月内从适应症选择推进到首次人体给药；官方管线页将 RTR242 标注为自噬/阿尔茨海默病小分子。", "summary": "RTR242 把自噬和溶酶体功能修复假设带入首次人体试验，是长寿机制药进入临床转化的标志节点。", "sources": [ "SRC-451", "SRC-452" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为公司自报临床进展，未绑定独立临床试验注册或已发表结果。", "cross_links": [ "HIT-INS-070", "HIT-TEC-013" ], "chapter": "长寿产业资金、联邦资助与健康寿命转化", "notes": "draft，等待来源语境复核。本轮已用 Retro 官方博客与管线页核验。", "created_at": "2026-08-06T15:49:36Z", "updated_at": "2026-08-06T15:49:36Z" }, { "event_id": "HIT-INS-071", "title": "ARPA-H 公布 PROSPR 首批 7 个研究团队并投入最高 1.44 亿美元", "date_start": "2026-02-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "2026 年 2 月 24 日，ARPA-H 官方宣布 PROSPR 项目首批 7 个美国研究团队，合同总额最高 1.44 亿美元、跨度五年，目标是识别衰老早期标志并启动健康寿命临床试验。", "summary": "PROSPR 从项目启动进入实质资助阶段，把健康寿命纳入联邦级研究基础设施。", "sources": [ "SRC-453" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "合同金额为上限且按里程碑拨付，不等同于已全部支出。", "cross_links": [ "HIT-POL-003", "HIT-INS-072", "HIT-INS-073" ], "chapter": "长寿产业资金、联邦资助与健康寿命转化", "notes": "draft，等待来源语境复核。本轮已用 ARPA-H 官方新闻稿核验。", "created_at": "2026-08-06T15:49:36Z", "updated_at": "2026-08-06T15:49:36Z" }, { "event_id": "HIT-INS-072", "title": "Cambrian Bio 获 ARPA-H PROSPR 最高 3080 万美元资助", "date_start": "2026-02-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "2026 年 2 月 24 日，Cambrian Bio 官方新闻稿宣布获 ARPA-H PROSPR 最高 3080 万美元资助，用于推进下一代 mTORC1 选择性抑制剂平台 TORnado，目标是改善老年人内在能力。", "summary": "Cambrian 的 PROSPR 资助把 mTOR 通路从抗衰药物开发升级为联邦健康寿命转化项目。", "sources": [ "SRC-454" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为按里程碑拨付的合同上限，不代表立即到账或临床疗效。", "cross_links": [ "HIT-INS-071", "HIT-INS-040" ], "chapter": "长寿产业资金、联邦资助与健康寿命转化", "notes": "draft，等待来源语境复核。本轮已用 Cambrian 官方新闻稿核验。", "created_at": "2026-08-06T15:49:36Z", "updated_at": "2026-08-06T15:49:36Z" }, { "event_id": "HIT-INS-073", "title": "Linnaeus Therapeutics 获 ARPA-H PROSPR 最高 2200 万美元资助", "date_start": "2026-02-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "2026 年 2 月 24 日，Linnaeus Therapeutics 通过 GlobeNewswire 宣布获 ARPA-H PROSPR 最高 2200 万美元合同，用于加速 LNS8801 健康寿命保护开发。", "summary": "Linnaeus 的 PROSPR 资助把 GPR35 激动剂 LNS8801 从候选药推进到联邦支持的衰老相关临床转化路径。", "sources": [ "SRC-455" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为合同上限和公司新闻稿，尚需临床数据和独立审阅。", "cross_links": [ "HIT-INS-071" ], "chapter": "长寿产业资金、联邦资助与健康寿命转化", "notes": "draft，等待来源语境复核。本轮已用 GlobeNewswire 官方新闻稿核验。", "created_at": "2026-08-06T15:49:36Z", "updated_at": "2026-08-06T15:49:36Z" }, { "event_id": "HIT-TEC-080", "title": "腹侧前中央回言语模式与响度编码研究发表", "date_start": "2026-04-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 4 月 15 日，《Nature Communications》发表研究，报告腹侧前中央回神经元对言语模式和响度的编码，为言语神经假体提供解码基础。", "summary": "该研究扩展了言语解码从音素到模式与响度的神经表征范围。", "sources": [ "SRC-456" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为神经编码研究，不等同于已部署临床言语假体。", "cross_links": [ "HIT-TEC-082", "HIT-TEC-075" ], "chapter": "脑机接口、言语解码与运动重建", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:58:07Z", "updated_at": "2026-08-06T15:58:07Z" }, { "event_id": "HIT-TEC-081", "title": "人左前中央回神经元手势编码研究发表", "date_start": "2025-08-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 8 月 30 日，《Communications Biology》发表研究，报告人左前中央回神经元群体对手势的编码，并讨论其对神经假体的意义。", "summary": "手势编码研究把 BCI 控制从连续运动扩展到多手势动作语义。", "sources": [ "SRC-457" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为神经编码研究，结果依赖特定受试者与电极设置。", "cross_links": [ "HIT-TEC-080", "HIT-TEC-083" ], "chapter": "脑机接口、言语解码与运动重建", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:58:07Z", "updated_at": "2026-08-06T15:58:07Z" }, { "event_id": "HIT-TEC-082", "title": "运动皮层内部言语研究为言语神经假体提供解码路径", "date_start": "2025-08-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 8 月 14 日，《Cell》在线发表研究，分析运动皮层内部言语编码及其对言语神经假体的意义。", "summary": "内部言语解码把 BCI 从可听见言语扩展到未发声的主观言语，是言语恢复的重要方向。", "sources": [ "SRC-458" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为单中心神经科学发现，尚需多受试者与临床验证。", "cross_links": [ "HIT-TEC-080", "HIT-TEC-075" ], "chapter": "脑机接口、言语解码与运动重建", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:58:07Z", "updated_at": "2026-08-06T15:58:07Z" }, { "event_id": "HIT-TEC-083", "title": "二维侵入式 BCI 多手势拖放解码研究发表", "date_start": "2025-04-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 4 月 10 日，《Journal of Neural Engineering》发表研究，报告二维侵入式 BCI 控制任务中的多手势拖放解码。", "summary": "多手势拖放把 BCI 从单点点击推进到更丰富的界面操作语义。", "sources": [ "SRC-459" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为实验室控制任务，不构成真实应用场景推广。", "cross_links": [ "HIT-TEC-081", "HIT-TEC-057" ], "chapter": "脑机接口、言语解码与运动重建", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:58:07Z", "updated_at": "2026-08-06T15:58:07Z" }, { "event_id": "HIT-SCI-099", "title": "BrainGate 14 名参与者皮层内微电极阵列长期表现预印本发布", "date_start": "2025-07-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "practice", "claim": "2025 年 7 月 2 日，BrainGate 团队发布 medRxiv 预印本，报告 14 名临床试验参与者中皮层内微电极阵列的长期表现。", "summary": "多参与者长期记录把 BCI 电极寿命从个案报告推进到群体性工程可靠性数据。", "sources": [ "SRC-460" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为预印本，尚未完成同行评审；结果需正式发表后复核。", "cross_links": [ "HIT-TEC-057", "HIT-TEC-077" ], "chapter": "脑机接口、言语解码与运动重建", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:58:07Z", "updated_at": "2026-08-06T15:58:07Z" }, { "event_id": "HIT-SCI-100", "title": "统计 AI 实现多元素催化剂精确筛选", "date_start": "2026-07-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 7 月 4 日，《Journal of the American Chemical Society》在线发表研究，提出统计描述符 phi 缩小材料理论计算与实验性能偏差，用于多元素催化剂精确筛选。", "summary": "该研究把统计 AI 引入材料筛选，弥补理论模型与真实合成材料之间的差距。", "sources": [ "SRC-461" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为特定材料体系的统计方法，不等同于通用材料发现引擎。", "cross_links": [ "HIT-THT-085", "HIT-THT-097" ], "chapter": "AI 自动化科研与材料发现", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:58:44Z", "updated_at": "2026-08-06T15:58:44Z" }, { "event_id": "HIT-SCI-101", "title": "AutoLabs 多代理自校正自主化学实验系统发表", "date_start": "2026-06-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 6 月 25 日，《Scientific Reports》发表 AutoLabs，一种可把自然语言指令转化为液体处理设备可执行协议并迭代自校正的多代理架构。", "summary": "AutoLabs 把自驱动实验室推进到多代理任务分解、工具计算和硬件执行闭环。", "sources": [ "SRC-462" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为特定液体处理平台评估，跨实验室泛化仍需验证。", "cross_links": [ "HIT-THT-085", "HIT-SCI-093" ], "chapter": "AI 自动化科研与材料发现", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:58:44Z", "updated_at": "2026-08-06T15:58:44Z" }, { "event_id": "HIT-THT-097", "title": "代理式 AI 与科学知识整合在系统生物学实验室验证", "date_start": "2026-07-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Sweden / United Kingdom", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "2026 年 7 月 8 日，《Journal of the Royal Society Interface》发表研究，提出把 LLM 代理与实验室自动化整合、并以逻辑脚手架引导系统生物学发现。", "summary": "该框架用结构化逻辑约束 LLM 代理，降低幻觉并增强可解释实验规划。", "sources": [ "SRC-463" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为实验室验证框架，结果依赖特定系统和任务。", "cross_links": [ "HIT-SCI-093", "HIT-SCI-101" ], "chapter": "AI 自动化科研与材料发现", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:58:44Z", "updated_at": "2026-08-06T15:58:44Z" }, { "event_id": "HIT-THT-098", "title": "AI 4.0 知识生成式科研观点发表", "date_start": "2026-07-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "2026 年 7 月 7 日，《Advanced Science》在线发表观点文章，提出第四代知识生成式 AI 4.0 从被动工具转向可自主提出假说的合作科学家。", "summary": "AI 4.0 把科研 AI 从信息综合推进到假说生成与多代理协作，是科研基础设施的重要概念转向。", "sources": [ "SRC-464" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为概念观点，不等同于已验证的自主科研能力。", "cross_links": [ "HIT-THT-086", "HIT-THT-097" ], "chapter": "AI 自动化科研与材料发现", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:58:44Z", "updated_at": "2026-08-06T15:58:44Z" }, { "event_id": "HIT-THT-099", "title": "AI 科学家组学数据驱动发现基准发表", "date_start": "2026-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "2026 年 7 月 1 日，《Bioinformatics》发表基准研究，评估 AI 科学家从真实组学实验数据中提取生物学洞见的能力。", "summary": "该基准把 AI 科研代理从演示推进到可比较、可复现的能力评估。", "sources": [ "SRC-465" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "基准覆盖范围有限，不能代表所有真实科研任务。", "cross_links": [ "HIT-SCI-093", "HIT-THT-097" ], "chapter": "AI 自动化科研与材料发现", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:58:44Z", "updated_at": "2026-08-06T15:58:44Z" }, { "event_id": "HIT-SCI-102", "title": "包裹细胞局部 IL2 治疗卵巢癌首次人体试验发表", "date_start": "2026-05-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "reconstruction", "event_type": "practice", "claim": "2026 年 5 月 11 日，《Clinical Cancer Research》在线发表首次人体试验，评估稳定表达局部 IL2 的包裹细胞用于高级别浆液性卵巢癌。", "summary": "该试验把可植入细胞工厂从概念推进到人体临床，是细胞治疗递送基础设施的关键节点。", "sources": [ "SRC-466" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为首次人体安全性试验，疗效与长期风险需后续研究。", "cross_links": [ "HIT-SCI-102", "HIT-SCI-103" ], "chapter": "细胞与基因疗法、再生医学与临床转化", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:59:21Z", "updated_at": "2026-08-06T15:59:21Z" }, { "event_id": "HIT-SCI-103", "title": "下一代肝细胞扩增连接分子重编程与类器官综述发表", "date_start": "2026-06-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "2026 年 6 月 16 日，《Stem Cell Reviews and Reports》在线发表综述，讨论分子重编程与多细胞类器官结合以推进肝细胞扩增临床转化。", "summary": "该综述把肝细胞再生产品从二维扩增转向可模拟组织的多细胞工程路径。", "sources": [ "SRC-467" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为临床前转化综述，不等同于人体肝细胞治疗获批。", "cross_links": [ "HIT-SCI-087", "HIT-SCI-102" ], "chapter": "细胞与基因疗法、再生医学与临床转化", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:59:21Z", "updated_at": "2026-08-06T15:59:21Z" }, { "event_id": "HIT-SCI-104", "title": "脐带间充质干细胞异质性产科精准治疗范式发表", "date_start": "2026-06-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "2026 年 6 月 4 日，《Stem Cell Reviews and Reports》在线发表综述，提出解码、映射和设计脐带间充质干细胞异质性以支持产科精准治疗。", "summary": "该范式把干细胞产品从批次均质假设转向异质性可设计的基础设施。", "sources": [ "SRC-468" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为概念与综述，尚需临床验证。", "cross_links": [ "HIT-SCI-103", "HIT-THT-100" ], "chapter": "细胞与基因疗法、再生医学与临床转化", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:59:21Z", "updated_at": "2026-08-06T15:59:21Z" }, { "event_id": "HIT-THT-100", "title": "AI 驱动细胞免疫治疗与 CAR-T 转化综述发表", "date_start": "2026-06-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "2026 年 6 月 18 日，《Physics of Life Reviews》在线发表综述，讨论 AI 在 CAR-T 工程与临床转化中的作用。", "summary": "该综述把 AI 从药物发现扩展到细胞疗法设计、制造和质量控制。", "sources": [ "SRC-469" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为领域综述，不等同于 AI 已主导 CAR-T 临床决策。", "cross_links": [ "HIT-SCI-102", "HIT-THT-098" ], "chapter": "细胞与基因疗法、再生医学与临床转化", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:59:21Z", "updated_at": "2026-08-06T15:59:21Z" }, { "event_id": "HIT-THT-101", "title": "衰老与长寿基因治疗综述发表", "date_start": "2026-06-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / United States", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "2026 年 6 月 17 日，《Trends in Molecular Medicine》在线发表综述，讨论基因操作在动物模型中调节寿命并评估向人类衰老与长寿临床疗法转化的挑战。", "summary": "该综述把基因治疗衰老从动物模型推进到临床转化边界评估。", "sources": [ "SRC-470" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "综述承认动物模型向人体转化仍困难，不构成人体疗效结论。", "cross_links": [ "HIT-SCI-087", "HIT-THT-100" ], "chapter": "细胞与基因疗法、再生医学与临床转化", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T15:59:21Z", "updated_at": "2026-08-06T15:59:21Z" }, { "event_id": "HIT-THT-102", "title": "虚拟人孪生用于乳腺癌动态轨迹决策支持", "date_start": "2026-07-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Austria", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "2026 年 7 月 9 日，《PLOS Digital Health》发表论文，提出虚拟人孪生把乳腺癌预测从静态快照推进为动态疾病轨迹决策支持。", "summary": "虚拟人孪生把数字健康从单次预测升级为可随治疗更新的持续模型。", "sources": [ "SRC-471" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为方法与应用论文，临床可及性和验证仍需后续研究。", "cross_links": [ "HIT-SCI-020", "HIT-THT-106" ], "chapter": "数字孪生、健康智能与主体状态建模", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:03:29Z", "updated_at": "2026-08-06T16:03:29Z" }, { "event_id": "HIT-THT-103", "title": "更年期数字孪生路线图发表", "date_start": "2026-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "France", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "2026 年 7 月 1 日，《Maturitas》在线发表路线图，提出整合内分泌动态、多系统生理和精准医学的绝经期数字孪生。", "summary": "该路线图把女性中老年健康从器官碎片化模型推进为多系统动态模型。", "sources": [ "SRC-472" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为路线图与概念，不是已部署临床系统。", "cross_links": [ "HIT-SCI-020", "HIT-THT-102" ], "chapter": "数字孪生、健康智能与主体状态建模", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:03:29Z", "updated_at": "2026-08-06T16:03:29Z" }, { "event_id": "HIT-THT-104", "title": "炎症性肠病数字孪生连接数据、生物与试验创新", "date_start": "2026-04-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Kingdom / Portugal / Canada / Italy / France", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "2026 年 4 月 29 日，《Gut》在线发表综述，讨论数字孪生在炎症性肠病中桥接数据、生物学与临床试验创新。", "summary": "该综述把数字孪生引入复杂慢性病试验设计，作为可模拟个体治疗路径的科研基础设施。", "sources": [ "SRC-473" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为领域综述，不等同于已用于监管试验。", "cross_links": [ "HIT-SCI-020", "HIT-THT-106" ], "chapter": "数字孪生、健康智能与主体状态建模", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:03:29Z", "updated_at": "2026-08-06T16:03:29Z" }, { "event_id": "HIT-THT-105", "title": "检验医学 2050 提出健康智能网络愿景", "date_start": "2026-07-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Belgium / France / South Korea / United States / International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "2026 年 7 月 27 日，《Clinical Chemistry and Laboratory Medicine》在线发表 IFCC 新兴技术部门愿景文章，提出检验医学从单点检测转向健康智能网络。", "summary": "健康智能网络把实验室数据纳入持续主体监测与预测基础设施。", "sources": [ "SRC-474" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为 2050 愿景文章，不是现行标准。", "cross_links": [ "HIT-THT-102", "HIT-THT-106" ], "chapter": "数字孪生、健康智能与主体状态建模", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:03:29Z", "updated_at": "2026-08-06T16:03:29Z" }, { "event_id": "HIT-THT-106", "title": "医疗诊断 AI 数字孪生范围综述发表", "date_start": "2026-06-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "2026 年 6 月 16 日，《Artificial Intelligence in Medicine》在线发表范围综述，系统梳理 AI 驱动数字孪生在医疗诊断中的核心技术、应用和实施障碍。", "summary": "该综述把数字孪生从分散案例整理为可评估的医学诊断基础设施。", "sources": [ "SRC-475" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "范围综述基于现有文献，实施障碍仍需监管与临床验证。", "cross_links": [ "HIT-SCI-020", "HIT-THT-104" ], "chapter": "数字孪生、健康智能与主体状态建模", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:03:29Z", "updated_at": "2026-08-06T16:03:29Z" }, { "event_id": "HIT-SCI-105", "title": "异种灌注综述提出机器灌注重塑异种移植", "date_start": "2026-05-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Switzerland", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "2026 年 5-6 月，《Xenotransplantation》发表综述，提出机器灌注在异种移植中扮演转化性角色，并指出肾异种移植首批临床试验正在进行。", "summary": "异种灌注把器官保存、修复与基因编辑猪器官供应链连接为可扩展移植基础设施。", "sources": [ "SRC-476" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "综述基于个案与早期试验，不等同于异种移植已常规化。", "cross_links": [ "HIT-SCI-074", "HIT-SCI-091" ], "chapter": "异种移植、器官保存与组织重建", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。；日期补齐：Crossref 2026-05-02 (published-online, day, v3)", "created_at": "2026-08-06T16:03:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-SCI-106", "title": "改善器官可及性的低温保存策略综述发表", "date_start": "2025-07-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "2025 年 7 月 24 日，《Transplantation》在线发表综述，系统讨论低温保存策略以改善器官移植可及性。", "summary": "该综述把低温保存从实验室技术推进为缓解移植器官稀缺的基础设施方案。", "sources": [ "SRC-477" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "为综述与策略梳理，不代表器官长期保存已普遍可行。", "cross_links": [ "HIT-TEC-019", "HIT-TEC-021" ], "chapter": "异种移植、器官保存与组织重建", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:03:56Z", "updated_at": "2026-08-06T16:03:56Z" }, { "event_id": "HIT-THT-107", "title": "器官移植现状挑战与未来综述发表", "date_start": "2026-01-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "2026 年 1 月 8 日，《MedComm》发表综述，把器官移植描述为整合免疫学、生物工程和数据科学的跨学科领域，并强调机器灌注、免疫抑制和器官稀缺问题。", "summary": "该综述为器官移植基础设施提供宏观图谱，连接临床、工程与数据科学。", "sources": [ "SRC-478" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为综述，不提供新临床试验证据。", "cross_links": [ "HIT-SCI-105", "HIT-THT-108" ], "chapter": "异种移植、器官保存与组织重建", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:03:56Z", "updated_at": "2026-08-06T16:03:56Z" }, { "event_id": "HIT-THT-108", "title": "美国首次人体异种移植公共媒体叙事分析发表", "date_start": "2026-07-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States / United Kingdom", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "2026 年 7-8 月，《Xenotransplantation》发表质性内容分析，研究美国当代首次人体异种移植的公共媒体表征。", "summary": "媒体叙事分析把异种移植公共信任纳入技术转化治理，是技术社会基础设施的一部分。", "sources": [ "SRC-479" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为媒体内容分析，不等同于公众总体意见或医疗结论。", "cross_links": [ "HIT-SCI-074", "HIT-THT-109" ], "chapter": "异种移植、器官保存与组织重建", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。；日期补齐：Crossref 2026-07-06 (published-online, day, v3)", "created_at": "2026-08-06T16:03:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-109", "title": "肾移植等待名单患者异种移植意愿研究发表", "date_start": "2026-07-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "2026 年 7-8 月，《Xenotransplantation》发表研究，调查肾移植等待名单患者对异种移植的接受意愿。", "summary": "患者视角研究把异种移植从医学可行性扩展到受者知情、信任与选择权问题。", "sources": [ "SRC-480" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "为单中心患者意愿研究，样本不能代表全球受者群体。", "cross_links": [ "HIT-SCI-074", "HIT-THT-108" ], "chapter": "异种移植、器官保存与组织重建", "notes": "draft，等待来源语境复核。本轮已用 PubMed/Crossref/DOI 元数据核验。；日期补齐：Crossref 2026-07-09 (published-online, day, v3)", "created_at": "2026-08-06T16:03:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-037", "title": "联合国老年人权利政府间工作组组织会议举行", "date_start": "2026-02-18", "date_end": "2026-02-19", "date_type": "range", "period_id": "period-21st-century", "civilization": "United Nations", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "联合国人权理事会第 58/13 号决议设立的老年人权利政府间工作组于 2026 年 2 月 18 日至 19 日在日内瓦万国宫举行组织会议。", "summary": "工作组开始落实以具有法律约束力的老年人权利国际文书为目标的机制安排，是老年人权利从议程走向公约谈判的关键制度节点。", "sources": [ "SRC-481" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "组织会议只是程序性开端，具体文书框架、条款和谈判日程仍待后续会议确定。", "cross_links": [ "HIT-POL-038" ], "chapter": "老年人权利治理", "notes": "OHCHR 官方页面核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-POL-038", "title": "联合国老年人权利政府间工作组首届会议举行", "date_start": "2026-07-13", "date_end": "2026-07-17", "date_type": "range", "period_id": "period-21st-century", "civilization": "United Nations", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "联合国老年人权利政府间工作组首届会议于 2026 年 7 月 13 日至 17 日举行，进入老年人权利公约的实质讨论阶段。", "summary": "首届会议把“老年不是负担”的权利框架推向联合国正式议事日程，直接影响长期照护、健康、收入保障和自主决策的制度设计。", "sources": [ "SRC-482" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "会议结果尚未形成定稿文书，成员国对公约形式与范围的立场差异仍可能改变进程。", "cross_links": [ "HIT-POL-037" ], "chapter": "老年人权利治理", "notes": "OHCHR 官方事件页面核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-POL-039", "title": "2026 世界老年人虐待防治日线上活动举行", "date_start": "2026-06-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United Nations", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "联合国经济和社会事务部于 2026 年 6 月 11 日举行世界老年人虐待防治日活动。", "summary": "活动聚焦地方政府、国家政策制定者与社区行动，把老年人免受虐待和暴力纳入可持续治理基础。", "sources": [ "SRC-483" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "活动属于倡导性节点，不能替代法律执行、服务供给和监测数据。", "cross_links": [ "HIT-POL-037" ], "chapter": "老年人权利治理", "notes": "UN DESA 官方活动页面核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-POL-041", "title": "UNECE 发布《改变老龄与老年人叙事》政策简报", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "Europe", "region": "Europe and Central Asia", "path_family": "social_composite", "event_type": "policy", "claim": "联合国欧洲经济委员会于 2026 年 6 月发布《老龄与老年人政策简报》第 31 号，系统讨论改变老龄叙事。", "summary": "简报把“负担叙事”识别为阻碍健康老龄化和老年权利落实的治理问题，主张以证据化、包容性和能力导向的叙事替代危机叙事。", "sources": [ "SRC-485" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "简报是政策倡导文本，不包含对各国执行情况的量化审计。", "cross_links": [ "HIT-POL-037", "HIT-POL-038" ], "chapter": "老年人权利治理", "notes": "UNECE 官方发布页核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-TEC-084", "title": "CorTec 脑机接口获 FDA 突破性设备认定", "date_start": "2026-04-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Germany", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 4 月 8 日，CorTec 的 Brain Interchange 系统获 FDA 突破性设备认定，用于慢性缺血性卒中运动康复。", "summary": "这是首个面向卒中运动康复的 BCI 突破性设备认定，把脑机接口从通信辅助扩展到治疗性神经调控。", "sources": [ "SRC-486" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "突破性设备认定属于加速审评通道，不证明临床有效或获批上市。", "cross_links": [ "HIT-TEC-034" ], "chapter": "脑机接口与神经增强", "notes": "CorTec 官方新闻稿核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-TEC-085", "title": "Paradromics 获 FDA 批准启动 Connect-One 早期可行性研究", "date_start": "2025-11-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2025 年 11 月 20 日，Paradromics 宣布其 Connexus 脑机接口获 FDA IDE 批准，启动 Connect-One 早期可行性研究。", "summary": "Connexus 是面向严重运动障碍者言语恢复与计算机控制的完全植入式高数据率 BCI，标志言语类 BCI 进入 FDA 监管轨道。", "sources": [ "SRC-487" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "IDE 批准只允许早期可行性研究，不代表长期安全性、有效性或商业批准。", "cross_links": [ "HIT-TEC-086" ], "chapter": "脑机接口与神经增强", "notes": "Paradromics 官方新闻稿核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-TEC-086", "title": "Paradromics 完成首例 Connexus 人体植入", "date_start": "2026-06-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 6 月 17 日，Paradromics 与密歇根大学宣布在 Connect-One 研究中完成首例 Connexus BCI 植入。", "summary": "首例植入把 Connexus 从监管批准推进到真实人体评估，为言语恢复和计算机控制的高数据率界面提供首批临床证据。", "sources": [ "SRC-488" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "单例植入不能外推到疗效，需等待完整早期可行性研究随访。", "cross_links": [ "HIT-TEC-085" ], "chapter": "脑机接口与神经增强", "notes": "Business Wire 官方新闻稿核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-TEC-087", "title": "Neuralink 发布 Telepathy 两年临床使用更新", "date_start": "2026-01-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 1 月 28 日，Neuralink 发布 Telepathy 脑机接口两年使用更新，展示首位长期参与者 Sebastian 的日常控制能力。", "summary": "两年使用更新提供了植入式 BCI 长期稳定性、设备使用模式和个人自主性改善的真实世界证据。", "sources": [ "SRC-489" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "更新属于公司叙事，样本量和独立测量有限，不能替代同行评审长期数据。", "cross_links": [ "HIT-TEC-078" ], "chapter": "脑机接口与神经增强", "notes": "Neuralink 官方更新页核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-TEC-088", "title": "Synchron Stentrode 累计植入达到 100 例里程碑", "date_start": "2026-06-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "United States", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "2026 年 6 月 9 日，行业报告称 Synchron Stentrode 经血管脑机接口已在多项临床研究中累计植入 100 例。", "summary": "100 例里程碑反映经血管 BCI 从早期可行性向关键试验和商业化准备的规模化趋势。", "sources": [ "SRC-490" ], "evidence_grade": "T", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "该里程碑来自行业报道，非 Synchron 官方审计报告；具体受试者分布、随访完整性和终点质量待原始数据核验。", "cross_links": [ "HIT-TEC-061", "HIT-TEC-068" ], "chapter": "脑机接口与神经增强", "notes": "行业新闻二手来源核验，未用公司官方统计代替。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-SCI-107", "title": "跨队列代谢组学年龄时钟研究发表", "date_start": "2026-07-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "Ireland", "region": "Europe", "path_family": "maintenance", "event_type": "technology", "claim": "2026 年 7 月 21 日，《GeroScience》发表代谢组学年龄时钟研究，验证其与衰弱和认知功能的跨队列关联。", "summary": "代谢组学年龄时钟把分子年龄从血液代谢物扩展到人群队列，为可重复的生物年龄测量提供新证据。", "sources": [ "SRC-491" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "跨队列验证仍依赖特定队列构成和测量平台，不能直接用于个体临床决策。", "cross_links": [ "HIT-SCI-080" ], "chapter": "衰老测量与生物年龄", "notes": "PubMed/DOI 元数据核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-SCI-108", "title": "BAGE 贝叶斯基因表达年龄预测框架发表", "date_start": "2026-06-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "2026 年 6 月 13 日，《BMC Bioinformatics》发表 BAGE，一种基于 PBMC 基因表达预测年龄的贝叶斯框架。", "summary": "BAGE 为转录组生物年龄提供概率化建模路径，有助于处理小样本、异质性和不确定性传播。", "sources": [ "SRC-492" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "方法以 PBMC 表达谱为对象，组织特异性和跨人群泛化仍需验证。", "cross_links": [ "HIT-SCI-107" ], "chapter": "衰老测量与生物年龄", "notes": "PubMed/DOI 元数据核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-SCI-109", "title": "BHARAT 印度人群多组学衰老研究发表", "date_start": "2026-04-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "India", "region": "South Asia", "path_family": "maintenance", "event_type": "technology", "claim": "2026 年 4 月 24 日，《Aging》发表 BHARAT 研究，构建印度人群的多模态、多组学衰老特征。", "summary": "BHARAT 补充了非西方人群的衰老测量空白，检验生物年龄指标是否能在不同遗传和环境下保持有效。", "sources": [ "SRC-493" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "研究仍处于表征阶段，样本覆盖和纵向随访不足以证明临床干预价值。", "cross_links": [ "HIT-SCI-107" ], "chapter": "衰老测量与生物年龄", "notes": "PubMed/DOI 元数据核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-SCI-110", "title": "PhysAge 多系统分子时钟预测健康与死亡风险", "date_start": "2025-09-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "2026 年 4 月，《GeroScience》发表 PhysAge，一种预测老年人健康与死亡风险的多系统分子时钟。", "summary": "PhysAge 把多组学信息整合为生理年龄，强化“生物年龄应预测功能与死亡结果”的验证标准。", "sources": [ "SRC-494" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "模型基于特定老年队列，外部人群、数据缺失和临床可解释性仍需评估。", "cross_links": [ "HIT-SCI-107", "HIT-SCI-108" ], "chapter": "衰老测量与生物年龄", "notes": "PubMed/DOI 元数据核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。；日期补齐：Crossref 2025-09-01 (published-online, day, v3)", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-110", "title": "DNA 甲基化年龄与衰弱关联系统综述发表", "date_start": "2025-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "2025 年 10 月，《Lancet Healthy Longevity》发表 DNA 甲基化时钟与衰弱的系统综述和荟萃分析。", "summary": "系统综述把甲基化生物年龄与临床衰弱终点连接起来，为生物年龄指标进入老年医学评估提供证据分层。", "sources": [ "SRC-495" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "不同甲基化时钟定义、队列异质性和发表偏倚可能影响合并效应。", "cross_links": [ "HIT-SCI-030", "HIT-SCI-079" ], "chapter": "衰老测量与生物年龄", "notes": "PubMed/DOI 元数据核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。；日期补齐：Crossref 2025-10 (published-print, month, v3)", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-PRA-017", "title": "Rentosertib 吸入溶液获 CDE 临床批件", "date_start": "2026-04-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "reconstruction", "event_type": "practice", "claim": "2026 年 4 月 28 日，Insilico Medicine 宣布其 rentosertib 吸入溶液获得中国 CDE 临床批件。", "summary": "吸入路线试图以直接肺靶向降低系统暴露，是 AI 设计候选药从口服扩展到处方形式的新转化节点。", "sources": [ "SRC-497" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "批件只允许开展临床研究，吸入制剂的药代、安全和疗效尚未验证。", "cross_links": [ "HIT-TEC-024", "HIT-PRA-018" ], "chapter": "AI 药物发现与临床转化", "notes": "Insilico 官方新闻核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-PRA-018", "title": "首个 AI 发现候选药进入 III 期试验", "date_start": "2026-07-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "China", "region": "Global", "path_family": "reconstruction", "event_type": "practice", "claim": "2026 年 7 月 7 日，Insilico Medicine 宣布启动 rentosertib 治疗特发性肺纤维化的 III 期临床试验。", "summary": "AI 发现候选药进入 III 期是生成式 AI 药物发现历史性里程碑，但其价值仍取决于 III 期疗效、安全性和监管结果。", "sources": [ "SRC-498" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "turning_point", "uncertainty": "III 期启动不保证成功；试验设计、入组、疗效和监管决定都可能改变结论。", "cross_links": [ "HIT-TEC-024", "HIT-PRA-017" ], "chapter": "AI 药物发现与临床转化", "notes": "Insilico 官方新闻核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-111", "title": "精准肿瘤学中的 AI 药物发现与临床转化经验综述发表", "date_start": "2026-04-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "2026 年 4 月 15 日，《BJC Reports》发表综述，总结 AI 驱动药物发现和临床转化的经验。", "summary": "综述强调 AI 药物发现必须接受临床转化、可复现性和结果验证的约束，为行业叙事提供审慎框架。", "sources": [ "SRC-499" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "综述是观点性证据整合，不代表具体药物临床结果。", "cross_links": [ "HIT-TEC-024" ], "chapter": "AI 药物发现与临床转化", "notes": "Crossref/DOI 元数据核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-THT-112", "title": "AI 设计或塑造药物进入人体试验数量增至 75 个以上", "date_start": "2026-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "2026 年 5 月行业盘点称，全球已有超过 75 个由 AI 设计或显著塑造的分子进入活跃人体临床试验。", "summary": "管线数量从个案转向规模化信号，但“进入试验”不等于“获批”，数量统计口径和临床质量仍需独立审查。", "sources": [ "SRC-500" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "该事件来自行业分析报告，非官方登记表；不同机构对“AI 设计”的定义可能不同。", "cross_links": [ "HIT-TEC-024", "HIT-PRA-018" ], "chapter": "AI 药物发现与临床转化", "notes": "二手行业报告核验，明确标注为统计口径需复核。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-TEC-089", "title": "冷冻保护生物墨水实现贴壁细胞直接生物打印", "date_start": "2026-03-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2026 年 7 月，《Advanced Materials》报道冷冻保护生物墨水可直接生物打印贴壁细胞。", "summary": "该材料把冷冻保护与打印成型结合，可能降低组织工程中细胞存活、运输和复温之间的流程摩擦。", "sources": [ "SRC-501" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "研究处于材料与细胞培养阶段，尚未达到器官级或临床验证。", "cross_links": [ "HIT-TEC-090" ], "chapter": "低温保存、3D 生物打印与再生", "notes": "Crossref/DOI 元数据核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。；日期补齐：Crossref 2026-03-11 (published-online, day, v3)", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-090", "title": "3D 生物打印材料、工艺与应用进展综述发表", "date_start": "2026-02-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "2026 年 2 月 25 日，《Micromachines》发表 3D 生物打印材料、工艺和新兴应用综述。", "summary": "综述梳理生物打印从结构支架走向血管化、多材料和功能组织的技术谱系，为组织重建提供路线参考。", "sources": [ "SRC-502" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "综述覆盖范围广，具体技术成熟度差异大，不能作为统一技术成熟度声明。", "cross_links": [ "HIT-TEC-089" ], "chapter": "低温保存、3D 生物打印与再生", "notes": "PubMed/DOI 元数据核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-SCI-112", "title": "卵巢组织冷冻保存现状与未来综述发表", "date_start": "2026-03-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "2026 年 3 月 31 日，《Frontiers in Reproductive Health》发表卵巢组织冷冻保存综述。", "summary": "卵巢组织保存是生育力保存和未来生殖选择权的基础路径，综述把技术现状、适用范围与长期结局放在同一框架。", "sources": [ "SRC-503" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "综述依赖现有临床随访，样本量、复苏率和长期生殖结局仍有限。", "cross_links": [ "HIT-SCI-113", "HIT-TEC-021" ], "chapter": "低温保存、3D 生物打印与再生", "notes": "PubMed/DOI 元数据核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-07T15:52:34Z" }, { "event_id": "HIT-SCI-113", "title": "子宫冷冻保存从实验模型到临床应用的转化综述发表", "date_start": "2025-12-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "2025 年 12 月 24 日，《Cureus》发表子宫冷冻保存转化综述。", "summary": "子宫冷冻保存把器官保存技术扩展到生殖系统，但临床可及性、复苏方案和伦理治理仍是主要边界。", "sources": [ "SRC-504" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "综述为转化框架，临床数据有限，不能证明子宫冷冻保存已可常规应用。", "cross_links": [ "HIT-SCI-112" ], "chapter": "低温保存、3D 生物打印与再生", "notes": "PubMed/DOI 元数据核验。 本轮已用官方页面/PubMed/Crossref/DOI 元数据核验。", "created_at": "2026-08-06T16:11:30Z", "updated_at": "2026-08-06T16:11:30Z" }, { "event_id": "HIT-THT-113", "title": "靶向 Gerozyme 的细胞重编程到组织年轻化综述发表", "date_start": "2026-01-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述提出通过靶向 gerozyme 把细胞重编程知识转化为组织年轻化策略。", "summary": "综述梳理细胞重编程、酶靶点和组织年轻化之间的转化路径，属于重编程谱系的机制框架节点。", "sources": [ "SRC-506" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程与年轻化", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-06T16:17:48Z" }, { "event_id": "HIT-THT-114", "title": "部分重编程作为衰老与疾病治疗策略综述发表", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述评估部分重编程作为衰老和疾病治疗策略的表观遗传年轻化前景。", "summary": "部分重编程是“只重置年龄、不抹除身份”路径的关键综述节点。", "sources": [ "SRC-507" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程与年轻化", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-FAI-012", "title": "体内化学重编程伴随脂滴毒性积累的失败证据发表", "date_start": "2026-01-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "failure", "claim": "该研究指出体内化学重编程可能伴随脂滴毒性积累，阻碍年轻化。", "summary": "这一失败证据限制化学重编程的“无基因编辑、天然安全”叙事，必须纳入风险边界。", "sources": [ "SRC-509" ], "evidence_grade": "L", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程与年轻化", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01-27 (published-online, day, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-115", "title": "芽殖酵母复制衰老与年轻化综述发表", "date_start": "2026-04-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述以芽殖酵母为模型讨论复制衰老与年轻化机制。", "summary": "酵母模型提供可重复、可量化的衰老与年轻化底层机制参照。", "sources": [ "SRC-510" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程与年轻化", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-06T16:17:48Z" }, { "event_id": "HIT-TEC-092", "title": "成孔毒素作为 senolytic 策略研究发表", "date_start": "2026-01-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究探索成孔毒素作为选择性清除衰老细胞的新策略。", "summary": "成孔毒素路线扩展了 senolytics 的工具空间，也带来毒性控制挑战。", "sources": [ "SRC-511" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、SASP 与 senolytics", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-06T16:17:48Z" }, { "event_id": "HIT-THT-116", "title": "个体化 senolytic 试验方法综述发表", "date_start": "2025-09-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该评论提出 senolytic 试验需要个体化设计。", "summary": "个体化设计把衰老负荷异质性纳入临床评价，是 senolytic 转化方法学的重要讨论。", "sources": [ "SRC-512" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、SASP 与 senolytics", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-06T16:17:48Z" }, { "event_id": "HIT-THT-117", "title": "细胞衰老驱动糖尿病动脉粥样硬化综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述系统讨论细胞衰老在糖尿病动脉粥样硬化中的作用与治疗含义。", "summary": "细胞衰老与慢性代谢疾病的因果连接是 senolytics 进入心血管场景的重要基础。", "sources": [ "SRC-513" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、SASP 与 senolytics", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-118", "title": "线粒体动力学与细胞衰老治疗潜力综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述分析线粒体动力学在细胞衰老中的机制与治疗潜力。", "summary": "线粒体与衰老的交互使线粒体动力学成为 senolytics 之外的靶向窗口。", "sources": [ "SRC-514" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、SASP 与 senolytics", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-119", "title": "血浆置换靶向 SASP 的衰老干预综述发表", "date_start": "2025-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述提出血浆置换可作为靶向 SASP 的衰老干预。", "summary": "血浆置换把细胞衰老的分泌效应作为系统性干预对象，是细胞衰老谱系的非药物路径。", "sources": [ "SRC-515" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、SASP 与 senolytics", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-09 (published-print, month, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-120", "title": "长寿医学中数字孪生作用综述发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论数字孪生在长寿医学中的角色。", "summary": "数字孪生把个体状态建模、预测和干预管理接入长寿医学，属于主体持续性的计算化路径。", "sources": [ "SRC-516" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿医学与健康寿命", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-121", "title": "单细胞多组学精准心血管与长寿医学转化综述发表", "date_start": "2025-11-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论单细胞多组学从方法到心血管和长寿医学临床转化的路径。", "summary": "单细胞数据为个体化长寿干预提供高分辨率生物学证据。", "sources": [ "SRC-517" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿医学与健康寿命", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-06T16:17:48Z" }, { "event_id": "HIT-TEC-093", "title": "延长线虫雄性寿命与生殖健康寿命的候选化合物研究发表", "date_start": "2026-02-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究筛选出延长线虫雄性寿命和生殖健康寿命的候选化合物。", "summary": "候选化合物以性别特异方式延长寿命，提示长寿干预不能只看整体寿命指标。", "sources": [ "SRC-518" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿医学与健康寿命", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-06T16:17:48Z" }, { "event_id": "HIT-TEC-094", "title": "COSMOS 随机试验两年多维生素补充代谢组结果发表", "date_start": "2026-03-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究报告 COSMOS 随机临床试验两年多维生素补充对代谢组的影响。", "summary": "大规模随机试验的代谢组终点为常见补充剂的健康寿命证据提供可测量结果。", "sources": [ "SRC-519" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿医学与健康寿命", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-06T16:17:48Z" }, { "event_id": "HIT-THT-122", "title": "寿命与健康寿命不同机制综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述区分寿命与健康寿命由不同机制支撑。", "summary": "把总寿命和健康寿命拆开，是避免“延寿却不健康”误导的关键概念节点。", "sources": [ "SRC-520" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿医学与健康寿命", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-123", "title": "器官保存到异种移植的可持续器官替代路径综述发表", "date_start": "2026-06-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述把器官保存与异种移植放在可持续器官替代的统一路径中。", "summary": "器官来源问题的技术谱系需要同时考虑保存、工程、异种和治理路径。", "sources": [ "SRC-521" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、器官保存与组织重建", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-06T16:17:48Z" }, { "event_id": "HIT-THT-124", "title": "异种移植提高器官可及性与器官贩运影响研究发表", "date_start": "2026-03-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究讨论异种移植增加器官可及性对器官贩运的潜在影响。", "summary": "器官供给变化会改变伦理、法律和全球公平结构，是异种移植的社会二阶效应。", "sources": [ "SRC-522" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、器官保存与组织重建", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03-23 (published-online, day, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-095", "title": "HLA-E 与 HLA-G 在异种器官移植中的潜在作用研究发表", "date_start": "2026-08-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究讨论 HLA-E 与 HLA-G 表达在异种器官移植中的免疫调节作用。", "summary": "免疫耐受分子是异种器官长期存活的底层工程接口。", "sources": [ "SRC-523" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、器官保存与组织重建", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-08-03 (published-online, day, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-125", "title": "临床猪器官移植经验回顾综述发表", "date_start": "2026-07-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述总结临床猪器官移植至今的经验。", "summary": "临床经验回顾是异种移植从个案进入监管与标准化评估的关键证据层。", "sources": [ "SRC-524" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、器官保存与组织重建", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07-04 (published-online, day, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-126", "title": "猪器官异种移植与常用药物相互作用综述发表", "date_start": "2025-11-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论猪器官异种移植可能改变常用药物代谢与使用的复杂性。", "summary": "异种器官的代谢差异会延伸到术后用药安全，是长期随访必须建模的变量。", "sources": [ "SRC-525" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、器官保存与组织重建", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-11-26 (published-online, day, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-096", "title": "胚胎形态自然语言 AI 基础模型研究发表", "date_start": "2026-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究提出胚胎形态自然语言描述的 AI 基础模型，支持数据高效下游训练。", "summary": "基础模型把临床文本形态描述转化为可训练表示，是生殖医学与生育保存领域的 AI 基础设施。", "sources": [ "SRC-526" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 生物医学与健康智能", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-04 (published-print, month, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-127", "title": "生物医学大型语言模型代理部署伦理调查发表", "date_start": "2025-12-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该调查系统讨论大型语言模型代理在生物医学部署中的伦理视角。", "summary": "AI 代理进入医学后，身份、责任、同意和数据治理边界需要独立伦理审查。", "sources": [ "SRC-527" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 生物医学与健康智能", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-12-04 (published-online, day, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-128", "title": "加速药物发现的机器学习与高通量工作流方法综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述批判性讨论基础模型与高通量计算工作流在药物发现中的方法学。", "summary": "方法学综述为 AI 药物发现的复现性、数据治理和有效性评估提供约束。", "sources": [ "SRC-528" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 生物医学与健康智能", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-097", "title": "认知衰老多模态预测与自适应干预 AI 数字孪生架构发表", "date_start": "2026-07-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究提出认知衰老多模态预测与自适应干预的 AI 数字孪生架构。", "summary": "认知数字孪生把主体认知状态建模、预测和干预闭环连接起来。", "sources": [ "SRC-529" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 生物医学与健康智能", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-06T16:17:48Z" }, { "event_id": "HIT-THT-129", "title": "结构生物学 AI 突破综述发表", "date_start": "2026-05-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述总结结构生物学中 AI 在蛋白结合剂设计与构象状态预测方面的突破。", "summary": "AI 蛋白设计能力直接影响药物、生物工具和未来医学工程的可能性空间。", "sources": [ "SRC-530" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 生物医学与健康智能", "notes": "第 83-87 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:17:48Z", "updated_at": "2026-08-06T16:17:48Z" }, { "event_id": "HIT-TEC-098", "title": "雷帕霉素一年安全与健康寿命指标 PEARL 试验结果发表", "date_start": "2025-04-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该试验报告雷帕霉素在健康成年人中一年后的安全与健康寿命指标。", "summary": "PEARL 是雷帕霉素健康成年人随机证据的关键节点，为延长寿命药物的人体试验提供临床锚点。", "sources": [ "SRC-531" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿药理学与老年医学试验", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-THT-130", "title": "健康成人超适应症使用雷帕霉素临床证据综述发表", "date_start": "2025-08-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述评估健康成年人超适应症使用雷帕霉素的临床证据。", "summary": "超适应症使用的证据审查把大众热度与临床可验证性分开。", "sources": [ "SRC-555" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿药理学与老年医学试验", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-THT-131", "title": "二甲双胍延缓心血管衰老综述发表", "date_start": "2026-01-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论二甲双胍作为延缓心血管衰老候选药物的机制与证据。", "summary": "二甲双胍进入老年科学试验后，其心血管效应成为健康寿命转化的重要分支。", "sources": [ "SRC-554" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿药理学与老年医学试验", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01-27 (published-online, day, v3)", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-PRA-019", "title": "达沙替尼联合槲皮素 pilot 临床试验方案发表", "date_start": "2025-03-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "practice", "claim": "该方案设计 Dasatinib 联合 Quercetin 的 pilot 临床试验，评估其对年龄相关健康和认知衰退的影响。", "summary": "D+Q 方案把 senolytics 从细胞实验推进到人体 pilot 试验，是可复现干预路径。", "sources": [ "SRC-553" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿药理学与老年医学试验", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-THT-132", "title": "重新审视二甲双胍作为 geroprotector 综述发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述重新评估二甲双胍作为衰老保护药物的证据与边界。", "summary": "对二甲双胍证据的反复审查是长寿药理学避免单一药物叙事的关键。", "sources": [ "SRC-535" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿药理学与老年医学试验", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；2026-08-07 修正来源交叉错绑：真实 DOI 为 10.1016/j.archger.2026.106208；2026-08-08 日期复核确认旧值 2026-03-09 来自非出版元数据并予以拒绝；合并后补重复事件 HIT-THT-257。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-08T06:28:04Z" }, { "event_id": "HIT-THT-133", "title": "抗衰老策略与离体器官年轻化综述发表", "date_start": "2025-03-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论抗衰老策略与离体器官年轻化。", "summary": "离体器官年轻化把再生医学和器官保存连接起来，指向可维护器官供应的未来路径。", "sources": [ "SRC-551" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞与再生医学", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-03-10 (published-online, day, v3)", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-134", "title": "干细胞从损伤检测到组织修复的再生旅程综述发表", "date_start": "2025-10-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述梳理干细胞在损伤检测和组织修复中的角色。", "summary": "干细胞再生功能需要从单一细胞治疗扩展为组织响应系统。", "sources": [ "SRC-550" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞与再生医学", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-THT-135", "title": "利用内源可塑性推进再生医学与年轻化观点发表", "date_start": "2026-07-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该观点主张利用内源可塑性而非完全重编程成熟细胞来推进再生医学。", "summary": "内源可塑性路径降低外来重编程风险，是再生医学从制造转向调动的重要视角。", "sources": [ "SRC-549" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞与再生医学", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-THT-136", "title": "间充质基质细胞胞外囊泡标准化与临床转化综述发表", "date_start": "2025-02-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论 MSC 胞外囊泡在再生医学中的标准化、生物工程和临床转化。", "summary": "无细胞再生疗法需要标准化、批次控制和监管接口才能进入临床。", "sources": [ "SRC-548" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞与再生医学", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-02-06 (published-online, day, v3)", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-137", "title": "仿生刺激响应水凝胶再生医学综述发表", "date_start": "2026-01-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论仿生刺激响应水凝胶的设计原则与临床转化。", "summary": "水凝胶材料是细胞递送和组织重建的工程基质。", "sources": [ "SRC-547" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞与再生医学", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-THT-138", "title": "脑机接口康复评估临床应用专家共识发表", "date_start": "2026-06-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该专家共识规范 BCI 在康复评估中的临床应用。", "summary": "临床共识把 BCI 从技术演示转向康复评估的可操作标准。", "sources": [ "SRC-546" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口与神经增强", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-THT-139", "title": "脑机接口临床实现距离综述发表", "date_start": "2025-12-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述评估 BCI 临床应用的实现距离与瓶颈。", "summary": "临床实现距离分析为 BCI 从早期研究进入常规医疗提供现实主义评估。", "sources": [ "SRC-545" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口与神经增强", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-12-25 (published-online, day, v3)", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-140", "title": "BCI 与无创脑刺激结合用于卒中运动恢复综述发表", "date_start": "2025-04-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述总结 BCI 与无创脑刺激结合用于卒中运动恢复的进展。", "summary": "组合神经技术把解码和调控结合，是神经康复增强路径。", "sources": [ "SRC-544" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口与神经增强", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-04-26 (published-online, day, v3)", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-141", "title": "UNESCO 神经技术伦理建议草案评论发表", "date_start": "2025-04-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该评论讨论 UNESCO 神经技术伦理建议草案。", "summary": "神经技术治理从国家规则走向国际伦理框架，是主体权利保护的重要节点。", "sources": [ "SRC-543" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口与神经增强", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-THT-142", "title": "神经技术文化叙事与伦理研究议程发表", "date_start": "2026-07-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究提出理解神经技术文化叙事、媒体表征和伦理治理的研究议程。", "summary": "文化叙事影响公众对脑机接口的期待、恐惧和治理需求。", "sources": [ "SRC-542" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口与神经增强", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-TEC-099", "title": "认知训练联合多组分运动改善健康老年人随机试验发表", "date_start": "2026-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该随机试验显示认知训练联合多组分运动改善健康老年人生物心理社会结局。", "summary": "联合干预为认知增强提供可执行的组合证据，而不仅依赖单一训练。", "sources": [ "SRC-541" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆与数字生物标志", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07-16 (published-online, day, v3)", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-100", "title": "工作记忆训练影响老年阅读技能研究发表", "date_start": "2026-02-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究检验工作记忆训练对老年阅读技能的影响。", "summary": "工作记忆作为通用任务资源，训练迁移到真实阅读任务具有重要意义。", "sources": [ "SRC-540" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆与数字生物标志", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-02-26 (published-online, day, v3)", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-143", "title": "海马认知假体中的记忆、身份与技术哲学分析发表", "date_start": "2025-02-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该论文分析海马认知假体中的记忆、身份与技术功能主义立场。", "summary": "记忆修复装置不仅恢复功能，也重定义主体连续性。", "sources": [ "SRC-539" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆与数字生物标志", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-TEC-101", "title": "游戏化认知衰老评估数字生物标志研究发表", "date_start": "2025-09-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究提出基于游戏的认知衰老评估作为数字生物标志。", "summary": "数字生物标志把认知测量扩展到日常场景，缩短干预反馈周期。", "sources": [ "SRC-538" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆与数字生物标志", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-TEC-102", "title": "言语数字生物标志用于认知障碍评估发表", "date_start": "2026-01-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究提出基于言语的认知障碍数字生物标志。", "summary": "言语代理测量可能提供低成本、高频率的认知状态监测。", "sources": [ "SRC-537" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆与数字生物标志", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-THT-144", "title": "老龄与长寿研究议程连接研究政策综述发表", "date_start": "2025-03-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该综述讨论老龄与长寿研究议程如何连接研究与政策。", "summary": "研究议程和治理议程必须协同，才能把长寿科学转化为公共价值。", "sources": [ "SRC-536" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康老龄化、公平与治理", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-THT-145", "title": "西班牙饮食与营养社会决定因素健康老龄化范围综述发表", "date_start": "2026-07-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该范围综述分析西班牙饮食与营养社会决定因素对健康老龄化的影响。", "summary": "营养健康不能只作为个体行为，必须纳入食物环境和社会支持。", "sources": [ "SRC-552" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康老龄化、公平与治理", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；2026-08-07 修正来源交叉错绑：真实 DOI 为 10.1007/s12062-026-09578-0，来源卡复用 SRC-552。；日期补齐：Crossref 2026-07-10 (published-online, day, v3)", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-08T06:28:04Z" }, { "event_id": "HIT-THT-146", "title": "居住照护环境作为健康老龄化决定因素研究发表", "date_start": "2025-03-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究把居住照护环境识别为健康老龄化的决定因素。", "summary": "建成环境和照护制度决定长期照护中的主体质量与尊严。", "sources": [ "SRC-534" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康老龄化、公平与治理", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-03-05 (published-online, day, v3)", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-PRA-020", "title": "痴呆住院患者需求与偏好定性研究发表", "date_start": "2025-05-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "practice", "claim": "该定性研究理解并整合住院环境中痴呆患者的照护需求与偏好。", "summary": "患者偏好进入照护设计，是主体持续性和尊严维护的微观治理节点。", "sources": [ "SRC-532" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康老龄化、公平与治理", "notes": "第 88-92 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:21:15Z", "updated_at": "2026-08-06T16:21:15Z" }, { "event_id": "HIT-TEC-103", "title": "CALERIE 2 试验热量限制对炎症表观遗传代理指标分析发表", "date_start": "2025-12-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该分析报告 CALERIE 2 试验中长期热量限制对炎症表观遗传代理指标的影响。", "summary": "热量限制试验把炎症表观遗传代理指标作为健康寿命干预的测量终点。", "sources": [ "SRC-556" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "饮食限制与代谢健康", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-TEC-104", "title": "热量限制对器官特异性生物衰老随机试验结果发表", "date_start": "2026-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该随机试验检验热量限制对器官特异性生物衰老的影响。", "summary": "器官特异性生物年龄是超越单一时钟的长寿干预评估方向。", "sources": [ "SRC-557" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "饮食限制与代谢健康", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-05 (published-print, month, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-105", "title": "CALERIE 热量限制改变小 RNA 谱研究发表", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究发现热量限制改变小 RNA 谱并参与年龄相关分子通路。", "summary": "小 RNA 为热量限制的分子机制提供非蛋白层面的生物标志。", "sources": [ "SRC-558" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "饮食限制与代谢健康", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-106", "title": "轻度睡眠限制改变外周血 DNA 甲基化随机交叉试验发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该随机交叉试验显示长期轻度睡眠限制改变外周血全表观基因组 DNA 甲基化。", "summary": "睡眠作为可干预资源，其表观遗传效应是长寿医学的重要边界。", "sources": [ "SRC-559" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "饮食限制与代谢健康", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-148", "title": "健康衰老饮食干预表观遗传视角综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述从表观遗传视角讨论饮食干预与健康衰老。", "summary": "饮食干预的效应必须通过表观遗传和长期分子测量连接。", "sources": [ "SRC-560" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "饮食限制与代谢健康", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-149", "title": "重置表观遗传时钟的椎间盘退变再生策略综述发表", "date_start": "2026-06-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论重置表观遗传时钟在椎间盘退变中的细胞衰老和再生策略。", "summary": "表观遗传重置进入局部组织修复场景，是重编程与再生医学交叉节点。", "sources": [ "SRC-561" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "表观遗传与衰老时钟", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-TEC-107", "title": "基于血液的内在能力表观遗传时钟开发发表", "date_start": "2025-06-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究开发基于血液的内在能力表观遗传时钟。", "summary": "把生物年龄与内在功能能力连接，是生物时钟进入功能评估的关键方法。", "sources": [ "SRC-562" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "表观遗传与衰老时钟", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-TEC-108", "title": "热带爪蟾表观遗传时钟建立", "date_start": "2025-05-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究建立热带爪蟾的表观遗传时钟。", "summary": "跨物种时钟为衰老机制的保守性和实验模型验证提供工具。", "sources": [ "SRC-563" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "表观遗传与衰老时钟", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-150", "title": "糖尿病加速表观遗传衰老与社会健康不平等综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该综述分析糖尿病中加速表观遗传衰老与社会健康不平等的社会生物通路。", "summary": "生物年龄不等同于纯粹分子指标，必须嵌入社会结构解释。", "sources": [ "SRC-564" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "表观遗传与衰老时钟", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-151", "title": "病毒潜伏驱动表观遗传时钟失调与免疫衰老研究发表", "date_start": "2026-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究讨论病毒潜伏作为表观遗传时钟失调和免疫衰老驱动因素。", "summary": "感染史应成为生物年龄模型的外生变量。", "sources": [ "SRC-565" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "表观遗传与衰老时钟", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-152", "title": "神经元自噬机制突破与治疗转化综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述总结神经元自噬的机制突破与治疗转化。", "summary": "神经元自噬是维持神经主体功能的关键蛋白稳态路径。", "sources": [ "SRC-566" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态与自噬", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-153", "title": "神经退行疾病自噬与蛋白酶体串扰综述发表", "date_start": "2026-02-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论神经退行疾病中自噬与蛋白酶体系统之间的串扰。", "summary": "蛋白清除系统不能单独建模，必须理解自噬与 UPS 的协同。", "sources": [ "SRC-567" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态与自噬", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-154", "title": "衰老蛋白稳态机制与治疗机会综述发表", "date_start": "2025-03-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论衰老中蛋白稳态的机制洞见与治疗机会。", "summary": "蛋白稳态维护是细胞质量控制的核心，也是长寿干预靶点。", "sources": [ "SRC-568" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态与自噬", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-155", "title": "选择性自噬在心血管疾病中的作用综述发表", "date_start": "2026-02-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论选择性自噬在心血管疾病中的机制与治疗潜力。", "summary": "选择性自噬连接蛋白质质量控制与心血管功能维护。", "sources": [ "SRC-569" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态与自噬", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-TEC-109", "title": "UBE2G1 在造血干细胞衰老中的蛋白稳态研究发表", "date_start": "2026-03-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究揭示 UBE2G1 在造血干细胞衰老中的蛋白稳态与信号连接。", "summary": "造血系统是全身更新能力的重要基础设施，蛋白稳态失衡会损害干细胞储备。", "sources": [ "SRC-570" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态与自噬", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-156", "title": "免疫衰老驱动心脏衰老综述发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论免疫衰老作为心脏衰老驱动因素。", "summary": "免疫系统状态是心血管和全身衰老之间的系统连接。", "sources": [ "SRC-571" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫衰老与炎症", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025 (published-online, year, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-110", "title": "宿主免疫衰老损害结核分枝杆菌清除研究发表", "date_start": "2026-02-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究发现宿主免疫衰老削弱结核分枝杆菌清除。", "summary": "免疫衰老会放大感染风险，是主体持续性的现实威胁。", "sources": [ "SRC-572" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫衰老与炎症", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-157", "title": "衰老与疫苗免疫应答综述发表", "date_start": "2026-07-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论免疫衰老和炎症衰老对疫苗应答的影响。", "summary": "疫苗策略必须适应老化免疫系统，才能维持公共健康基础设施。", "sources": [ "SRC-573" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫衰老与炎症", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-TEC-111", "title": "外周免疫衰老生物标志与认知下降人群研究发表", "date_start": "2026-06-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该人群研究检验外周免疫衰老生物标志与纵向认知下降的关联。", "summary": "免疫衰老标志物可成为认知风险监测的可及窗口。", "sources": [ "SRC-574" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫衰老与炎症", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-158", "title": "慢性炎症驱动肿瘤免疫衰老综述发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论慢性炎症驱动的肿瘤免疫衰老机制与治疗策略。", "summary": "免疫衰老同时是肿瘤风险和免疫治疗障碍。", "sources": [ "SRC-575" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫衰老与炎症", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025 (published-online, year, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-159", "title": "健康寿命导向照护心脏代谢德尔菲框架发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究提出健康寿命导向照护的心脏代谢德尔菲框架。", "summary": "健康寿命照护需要把心血管代谢风险与功能终点统一。", "sources": [ "SRC-576" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管与健康寿命框架", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-160", "title": "超越寿命与健康寿命的经验性长寿生物学框架发表", "date_start": "2026-04-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究提出“体验性长寿”的生物学框架。", "summary": "主体持续性不仅要延长存在，还要维持可感知、可行动的时间质量。", "sources": [ "SRC-577" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管与健康寿命框架", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-161", "title": "衰老机制冗余与层级结构综述发表", "date_start": "2026-06-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述分析衰老机制的冗余和层级结构。", "summary": "单一干预难以覆盖全部衰老机制，冗余结构决定组合策略。", "sources": [ "SRC-578" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管与健康寿命框架", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-INS-074", "title": "Discover Aging 跨学科健康寿命研究期刊创建", "date_start": "2026-02-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "institution", "claim": "Discover Aging 期刊宣布创建，作为理解与改善健康寿命的多学科研究平台。", "summary": "新期刊标志健康寿命研究从零星论文进入结构化学术基础设施。", "sources": [ "SRC-580" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管与健康寿命框架", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-163", "title": "脑衰老与神经退行中神经炎症和细胞衰老综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论神经炎症和细胞衰老在脑衰老与神经退行中的作用。", "summary": "脑内炎症和衰老细胞是认知退化与神经修复的共同靶点。", "sources": [ "SRC-581" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行与脑健康", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-164", "title": "神经韧性掩盖神经退行的衰老脑研究发表", "date_start": "2026-07-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究讨论神经韧性如何掩盖神经退行过程。", "summary": "神经韧性概念要求同时测量损伤与代偿，避免只看到症状。", "sources": [ "SRC-582" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行与脑健康", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-TEC-112", "title": "PLCG2 信号与阿尔茨海默病遗传韧性研究发表", "date_start": "2026-03-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究分析 PLCG2 信号在阿尔茨海默病中的遗传韧性作用。", "summary": "遗传韧性靶点可能揭示保护性信号通路，为干预提供新接口。", "sources": [ "SRC-583" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行与脑健康", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-165", "title": "星形胶质细胞自噬从韧性到脆弱性综述发表", "date_start": "2026-03-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论星形胶质细胞自噬在衰老与神经退行中从韧性到脆弱性的转变。", "summary": "胶质细胞自噬决定神经微环境的修复能力。", "sources": [ "SRC-584" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行与脑健康", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-166", "title": "星形胶质细胞脂质代谢与脑健康综述发表", "date_start": "2026-08-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论星形胶质细胞脂质代谢在脑健康与神经退行中的双重作用。", "summary": "脂质代谢是脑能量和炎症之间未被充分建模的接口。", "sources": [ "SRC-585" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行与脑健康", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-167", "title": "精子与卵母细胞保存生物技术进展综述发表", "date_start": "2026-02-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述总结精子和卵母细胞保存的生物技术进展。", "summary": "生殖细胞保存是保留未来生育选择权的基础设施。", "sources": [ "SRC-586" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖健康与生育保存", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-168", "title": "子宫内膜异位症生育保存策略综述发表", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述评估子宫内膜异位症患者的生育保存手术风险与新兴方案。", "summary": "疾病治疗与生育保存需要同步规划，避免牺牲未来选择权。", "sources": [ "SRC-587" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖健康与生育保存", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-169", "title": "特纳综合征患者生育保存 SWOT 分析发表", "date_start": "2026-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究对特纳综合征患者生育保存进行 SWOT 分析。", "summary": "特殊人群生育保存需要结合临床、心理和伦理约束。", "sources": [ "SRC-588" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖健康与生育保存", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-04 (published-print, month, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-170", "title": "肿瘤生殖学外泌体与生育保存综述发表", "date_start": "2026-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论外泌体在化疗生殖损伤和生育保存中的作用。", "summary": "外泌体路径可能减少化疗对生殖储备的破坏。", "sources": [ "SRC-589" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖健康与生育保存", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-THT-171", "title": "年轻肿瘤患者生育保存结局综述发表", "date_start": "2026-04-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述分析年轻肿瘤患者不同癌种生育保存的生殖结局。", "summary": "生育保存结局需按癌种、治疗强度和随访时间分层。", "sources": [ "SRC-590" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖健康与生育保存", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-06T16:23:38Z" }, { "event_id": "HIT-TEC-113", "title": "AI 发展与老年人主观幸福感纵向研究发表", "date_start": "2026-05-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究利用中国纵向老龄化社会调查分析 AI 发展与老年人主观幸福感。", "summary": "AI 基础设施对主体福祉的影响必须进入经验评估，而非只讨论能力。", "sources": [ "SRC-591" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字健康与可穿戴", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-05-16 (published-online, day, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-114", "title": "可穿戴传感器与可解释机器学习评估轻度认知障碍功能衰退发表", "date_start": "2026-04-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究使用可穿戴传感器与可解释机器学习评估轻度认知障碍功能衰退。", "summary": "可解释机器学习让数字健康模型进入临床信任边界。", "sources": [ "SRC-592" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字健康与可穿戴", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-04-25 (published-online, day, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-115", "title": "数字应用与可穿戴设备野外纵向数据采集研究发表", "date_start": "2026-07-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究分享办公和生产工人的纵向野外数字应用与可穿戴数据采集经验。", "summary": "真实世界数据采集是长期主体状态监测的工程基础。", "sources": [ "SRC-593" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字健康与可穿戴", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07-15 (published-online, day, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-172", "title": "可穿戴设备心血管诊断监测综述发表", "date_start": "2026-07-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述总结可穿戴设备在心血管疾病诊断、监测和管理中的应用。", "summary": "可穿戴心血管监测把风险发现嵌入日常时间。", "sources": [ "SRC-594" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字健康与可穿戴", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07-29 (published-online, day, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-116", "title": "可穿戴睡眠数字生物标志与幸福感纵向观察研究发表", "date_start": "2026-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该纵向观察研究检验可穿戴睡眠数字生物标志与幸福感的关联。", "summary": "睡眠数字生物标志连接恢复能力与主观时间质量。", "sources": [ "SRC-595" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字健康与可穿戴", "notes": "第 93-100 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-02 (published-print, month, v3)", "created_at": "2026-08-06T16:23:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-173", "title": "衰老作为网络化过程综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述把衰老建模为跨系统、跨信号和跨干预的网络化过程。", "summary": "网络化模型超越单变量寿命预测，为主体状态建模提供系统接口。", "sources": [ "SRC-596" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "寿命建模与预测", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-174", "title": "峰值生产寿命定义与量化框架发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究提出峰值生产寿命的定义、量化与扩展框架。", "summary": "生产性寿命把寿命质量从健康维度扩展到创造与行动维度。", "sources": [ "SRC-597" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "寿命建模与预测", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-117", "title": "裸盖菇素延长细胞寿命并改善老龄小鼠生存研究发表", "date_start": "2025-07-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究发现裸盖菇素延长细胞寿命并改善老龄小鼠生存。", "summary": "精神活性物质的寿命效应进入实证研究，但机制和安全性仍需谨慎。", "sources": [ "SRC-598" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "寿命建模与预测", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-TEC-118", "title": "线粒体 NAD+/NADH 比率遗传操纵延长寿命并改善阿尔茨海默表型研究发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究通过遗传操纵线粒体 NAD+/NADH 比率延长寿命并改善阿尔茨海默病表型。", "summary": "线粒体氧化还原状态是寿命和神经退行之间的共享代谢变量。", "sources": [ "SRC-599" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "寿命建模与预测", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-INS-075", "title": "PLOS Aging and Health 期刊创建", "date_start": "2026-07-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "institution", "claim": "PLOS 创建 Aging and Health 期刊，聚焦全生命周期老龄整合科学。", "summary": "新期刊强化衰老研究的多学科发布基础设施。", "sources": [ "SRC-600" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "寿命建模与预测", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-TEC-119", "title": "人脑组织保存方法蛋白质组比较研究发表", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究比较不同人脑组织保存方法的蛋白质组稳定性。", "summary": "脑保存方法直接决定未来分子分析、神经科学研究和潜在重建信息质量。", "sources": [ "SRC-601" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存与连接组", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-120", "title": "大核连接组生成网络用于阿尔茨海默病分析发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究提出用于阿尔茨海默病分析的大核连接组生成网络。", "summary": "连接组生成网络把脑网络建模与疾病预测结合。", "sources": [ "SRC-602" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存与连接组", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-175", "title": "连接组引导胶质瘤切除系统综述发表", "date_start": "2026-02-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该系统综述评估连接组引导胶质瘤切除对白质保留和术后认知的影响。", "summary": "手术保留连接组结构是保护主体认知连续性的临床策略。", "sources": [ "SRC-603" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存与连接组", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-TEC-121", "title": "特发性正常压力脑积水全脑连接组分析发表", "date_start": "2026-04-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究通过全脑连接组分析揭示特发性正常压力脑积水的结构网络特征。", "summary": "全脑连接组为可逆性脑疾病的早期识别提供网络级指标。", "sources": [ "SRC-604" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存与连接组", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-176", "title": "多发性硬化突触连接组与液体生物标志综述发表", "date_start": "2026-03-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述讨论多发性硬化突触连接组与液体生物标志的联系。", "summary": "连接组结构变化需要与可检测的生物标志建立可逆映射。", "sources": [ "SRC-605" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存与连接组", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-TEC-122", "title": "绵羊卵巢组织慢冻与玻璃化存活比较研究发表", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究比较绵羊卵巢组织慢速冷冻与玻璃化后的存活能力。", "summary": "卵巢组织保存方法比较为生殖和激素功能保留提供转化证据。", "sources": [ "SRC-606" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "低温保存与生物停滞", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-123", "title": "小鼠主动脉玻璃化保存研究发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究探索小鼠主动脉玻璃化用于血管组织保存。", "summary": "血管组织玻璃化是复杂器官保存的组分级基础。", "sources": [ "SRC-607" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "低温保存与生物停滞", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-177", "title": "卵巢组织慢速冷冻与玻璃化质量比较荟萃分析发表", "date_start": "2025-03-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "该荟萃分析比较卵巢组织慢速冷冻与玻璃化的质量。", "summary": "系统比较为临床选择保存方案提供证据基础。", "sources": [ "SRC-608" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "低温保存与生物停滞", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-TEC-124", "title": "载体辅助玻璃化装置推动卵母细胞标准化保存发表", "date_start": "2026-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究介绍载体辅助玻璃化装置用于卵母细胞标准化保存。", "summary": "标准化设备降低操作差异，是生殖保存可复现性的关键。", "sources": [ "SRC-609" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "低温保存与生物停滞", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-TEC-125", "title": "化学限定玻璃化培养基用于牛胚胎冷冻发表", "date_start": "2026-01-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究评估化学限定玻璃化培养基结合直接转移系统的牛胚胎冷冻效果。", "summary": "化学限定培养基减少动物源成分，改善冷冻流程的标准化和安全性。", "sources": [ "SRC-610" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "低温保存与生物停滞", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-178", "title": "3D 生物打印器官移植工程综述发表", "date_start": "2026-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述总结 3D 生物打印用于器官生物工程的进展。", "summary": "生物打印把器官替代从异种和捐献扩展到按需工程制造。", "sources": [ "SRC-611" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物打印与器官工程", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-02 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-126", "title": "无支架光基高细胞密度生物打印研究发表", "date_start": "2026-01-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究实现高细胞密度无支架光基生物打印。", "summary": "高密度细胞打印接近组织真实细胞密度，是器官工程的关键工艺突破。", "sources": [ "SRC-612" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物打印与器官工程", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01-16 (published-online, day, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-179", "title": "熔体电写骨修复支架综述发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论熔体电写骨修复支架的架构与材料选择。", "summary": "支架制造精度决定骨组织再生的机械和生物学环境。", "sources": [ "SRC-613" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物打印与器官工程", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-180", "title": "支架与无支架 3D 生物打印组织工程综述发表", "date_start": "2026-08-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述总结支架和无支架 3D 生物打印在组织工程中的进展。", "summary": "支架与无支架路径各有成熟度和局限，需要按组织目标选择。", "sources": [ "SRC-614" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物打印与器官工程", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-TEC-127", "title": "3D 打印 PLGA/PLA 支架用于骨癌双模式治疗研究发表", "date_start": "2026-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究开发 3D 打印 PLGA/PLA 支架实现骨癌双模式治疗。", "summary": "功能化支架把组织修复与局部治疗结合，是重建医学的一体化方向。", "sources": [ "SRC-615" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物打印与器官工程", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-02 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-181", "title": "生成式 AI 药物发现与蛋白设计综述发表", "date_start": "2025-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述讨论生成式 AI 在药物发现和蛋白设计中的前沿角色。", "summary": "生成式 AI 把分子设计从搜索扩展为创造，直接影响药物和生物工具。", "sources": [ "SRC-616" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 蛋白与药物设计", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-09 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-182", "title": "类器官-AI 平台药物发现治理观点发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该观点提出类器官-AI 平台需要整合治理。", "summary": "类器官与 AI 组合产生数据、伦理和监管的新接口。", "sources": [ "SRC-617" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 蛋白与药物设计", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-183", "title": "制药研发生成式 AI 从大模型到代理与监管综述发表", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述讨论生成式 AI 从大语言模型到代理再到监管的制药研发路径。", "summary": "AI 代理进入制药闭环后，监管必须覆盖自动化决策链。", "sources": [ "SRC-618" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 蛋白与药物设计", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-184", "title": "AI 原生药物设计五年议程发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该研究提出 AI 原生药物设计的五年议程。", "summary": "议程强调机制、可监管性和全球公平，避免 AI 药物设计仅追求速度。", "sources": [ "SRC-619" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 蛋白与药物设计", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-185", "title": "AI 重新定义药物递送系统逆向设计综述发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述讨论 AI 如何从试错转向逆向设计药物递送系统。", "summary": "递送系统设计进入逆向工程阶段，可减少无效尝试成本。", "sources": [ "SRC-620" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 蛋白与药物设计", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-128", "title": "患者中心数字孪生联邦增量学习框架发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究提出患者中心数字孪生框架，支持联邦增量学习。", "summary": "联邦学习让数字孪生在不集中隐私数据的前提下持续更新。", "sources": [ "SRC-621" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生与个体建模", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-print, year, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-186", "title": "数字孪生是科学还是工程观点发表", "date_start": "2026-01-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该观点讨论数字孪生属于科学还是工程。", "summary": "数字孪生的理论地位决定其验证标准和可信边界。", "sources": [ "SRC-622" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生与个体建模", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-TEC-129", "title": "患者流与临床调度 AI 智能数字孪生框架发表", "date_start": "2026-07-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究提出患者流和临床调度的 AI 数字孪生框架。", "summary": "医疗系统数字孪生把个体主体状态嵌入系统级资源调度。", "sources": [ "SRC-623" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生与个体建模", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-187", "title": "乳腺癌类器官精准建模平台综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论乳腺癌类器官作为精准建模平台的作用。", "summary": "患者来源类器官为个体化治疗和数字模型验证提供湿实验接口。", "sources": [ "SRC-624" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生与个体建模", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-print, year, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-188", "title": "香豆素与精准医学药物基因组学综述发表", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论香豆素在个体化治疗设计中的分子机制与药物基因组学。", "summary": "药物基因组学为精准医学提供分子水平的个体化依据。", "sources": [ "SRC-625" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生与个体建模", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-189", "title": "家庭长期照护者负担生物心理社会视角综述发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该综述从生物心理社会视角分析居家长期照护者负担。", "summary": "照护者健康是主体持续性的外部支持基础设施。", "sources": [ "SRC-626" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "照护系统与社会支持", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-TEC-130", "title": "辅助设备与长期照护机构照护者留任研究发表", "date_start": "2025-09-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究分析辅助设备与长期照护机构照护者留任的关系。", "summary": "辅助技术减少照护负荷，可改善照护系统的可持续性。", "sources": [ "SRC-627" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "照护系统与社会支持", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-190", "title": "疫情期养老院痴呆照护人格与照护者压力研究发表", "date_start": "2025-12-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究从疫情经验中分析养老院痴呆照护中的人格承认与照护者压力。", "summary": "人格承认是照护质量的核心，而不只是任务执行效率。", "sources": [ "SRC-628" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "照护系统与社会支持", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-191", "title": "长期照护人员营养教育范围综述发表", "date_start": "2026-07-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该范围综述总结长期照护人员营养教育以支持老年人营养照护。", "summary": "照护人员能力建设直接影响日常营养和恢复。", "sources": [ "SRC-629" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "照护系统与社会支持", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-TEC-131", "title": "家庭照护者负担与居家照护质量有效性研究发表", "date_start": "2026-07-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究分析居家照护质量在家庭照护者负担与服务有效性中的作用。", "summary": "服务质量是连接照护者负担和主体结局的调节变量。", "sources": [ "SRC-630" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "照护系统与社会支持", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07-03 (published-print, day, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-192", "title": "脂质递送系统精准纳米医学用于肺结核综述发表", "date_start": "2026-01-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论脂质递送系统在肺结核精准纳米医学中的作用。", "summary": "脂质递送系统是药物到达病灶和降低毒性的成熟纳米平台。", "sources": [ "SRC-631" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学与递送系统", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-193", "title": "生物标志驱动 AI 辅助纳米医学乳腺癌综述发表", "date_start": "2026-06-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论生物标志驱动和 AI 辅助纳米医学用于乳腺癌精准递送。", "summary": "AI 与纳米医学结合可提高递送设计的个体化水平。", "sources": [ "SRC-632" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学与递送系统", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-195", "title": "纳米医学穿越血脑屏障治疗阿尔茨海默病综述发表", "date_start": "2026-03-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论纳米医学穿越血脑屏障治疗阿尔茨海默病的策略。", "summary": "血脑屏障递送是神经修复和认知干预的物理瓶颈。", "sources": [ "SRC-634" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学与递送系统", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-196", "title": "空间组学引导纳米医学精准递送综述发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论空间组学引导纳米医学的下一代精准递送。", "summary": "空间信息让纳米递送从组织级进入微环境级。", "sources": [ "SRC-635" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学与递送系统", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-197", "title": "认知计算神经科学未来十年综述发表", "date_start": "2026-06-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述展望认知计算神经科学未来十年。", "summary": "计算神经科学是脑模拟、BCI 和认知增强的共同理论层。", "sources": [ "SRC-636" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "计算神经科学与脑模拟", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06-08 (published-online, day, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-198", "title": "基于尖峰网络的意识计算神经病学模型发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该研究建立基于生物尖峰网络的意识计算神经病学模型。", "summary": "计算模型把意识损伤从临床描述转化为可模拟机制。", "sources": [ "SRC-637" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "计算神经科学与脑模拟", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-print, year, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-199", "title": "贝叶斯大脑理论计算神经科学综述发表", "date_start": "2025-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述讨论贝叶斯大脑理论中的信念计算。", "summary": "贝叶斯大脑为感知、学习和预测提供统一计算框架。", "sources": [ "SRC-638" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "计算神经科学与脑模拟", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-02 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-200", "title": "全脑机制是否支撑注意与意识研究发表", "date_start": "2026-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该研究讨论注意与意识是否由全脑机制支撑。", "summary": "全脑尺度建模是理解主体状态涌现的必要层次。", "sources": [ "SRC-639" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "计算神经科学与脑模拟", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-05 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-132", "title": "帕金森病慢性自适应深脑刺激居家监测研究发表", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究实现帕金森病慢性自适应深脑刺激的居家监测。", "summary": "居家闭环神经调控把治疗从医院扩展到主体日常生活。", "sources": [ "SRC-640" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "计算神经科学与脑模拟", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-201", "title": "国际 AI 安全报告 2026 政策审计与治理分析发表", "date_start": "2026-06-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究对 2026 国际 AI 安全报告进行政策审计和治理分析。", "summary": "AI 安全报告进入学术治理审查，是安全主张公开可争议化的节点。", "sources": [ "SRC-641" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "治理与伦理", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-202", "title": "老龄与照护中 AI 问责从伦理到治理研究发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究讨论老龄与照护中 AI 从伦理原则到治理问责的转化。", "summary": "照护 AI 治理必须落到责任主体、监测和申诉机制。", "sources": [ "SRC-642" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "治理与伦理", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-203", "title": "生成式系统确定性治理运行时发表", "date_start": "2026-07-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究提出生成式系统确定性治理运行时以验证 AI 输出。", "summary": "策略对齐运行时是 AI 输出进入高风险决策前的机器门禁。", "sources": [ "SRC-643" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "治理与伦理", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-204", "title": "欧盟 AI 伦理治理混合专业知识研究发表", "date_start": "2025-05-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究分析欧盟 AI 伦理治理中的混合专业知识和专业权力。", "summary": "伦理治理不能只靠原则，必须分析专家权力和制度结构。", "sources": [ "SRC-644" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "治理与伦理", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-06T16:26:13Z" }, { "event_id": "HIT-THT-205", "title": "残障权利视角重新构想神经技术治理研究发表", "date_start": "2026-05-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究通过残障权利视角重新构想神经技术治理。", "summary": "神经技术治理应以主体能力和权利为中心，而非仅以器械安全为中心。", "sources": [ "SRC-645" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "治理与伦理", "notes": "第 101-110 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-05-14 (published-online, day, v3)", "created_at": "2026-08-06T16:26:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-206", "title": "运动作为 geroprotector 聚焦表观遗传衰老综述发表", "date_start": "2025-07-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论运动作为 geroprotector 并聚焦表观遗传衰老。", "summary": "运动是无需新药即可进入人体验证的衰老保护干预。", "sources": [ "SRC-646" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "抗衰老药物与 geroprotector", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-THT-207", "title": "大模型与 AI 生命模型用于中药 geroprotector 配方研究发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该研究讨论大语言模型和 AI 生命模型用于中药来源 geroprotector 配方。", "summary": "AI 生命模型把传统知识转化为可筛选、可验证的候选干预。", "sources": [ "SRC-647" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "抗衰老药物与 geroprotector", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025 (published-online, year, v3)", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-133", "title": "硝唑尼特在线虫与加速衰老小鼠中的抗衰老作用研究发表", "date_start": "2026-02-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究检验硝唑尼特在线虫和加速衰老小鼠中的抗衰老作用。", "summary": "老药新用为 geroprotector 发现提供低门槛候选路径。", "sources": [ "SRC-648" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "抗衰老药物与 geroprotector", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-THT-208", "title": "基于 AI 与多组学的抗衰老和年龄相关疾病药物发现进展发表", "date_start": "2026-06-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该研究综述 AI 与多组学在抗衰老药物发现中的进展。", "summary": "AI 与多组学组合是 geroprotector 发现的下一代基础设施。", "sources": [ "SRC-649" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "抗衰老药物与 geroprotector", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-THT-209", "title": "AI 可编程虚拟人用于生理药理学药物发现发表", "date_start": "2025-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述讨论 AI 可编程虚拟人用于人体生理药物发现。", "summary": "虚拟人模型把个体生理状态转化为可试错的药物发现空间。", "sources": [ "SRC-650" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "抗衰老药物与 geroprotector", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-11 (published-print, month, v3)", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-210", "title": "细胞重编程作为激进年轻化策略综述发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论细胞重编程作为激进年轻化策略。", "summary": "激进年轻化路径把重编程从修复推向状态改写。", "sources": [ "SRC-651" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程与年轻化", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025 (published-online, year, v3)", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-134", "title": "直接心脏重编程克服年龄相关代谢障碍研究发表", "date_start": "2025-05-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究讨论直接心脏重编程中年龄相关代谢障碍。", "summary": "心脏再生需要同时克服细胞命运和代谢环境双重障碍。", "sources": [ "SRC-652" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程与年轻化", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-THT-211", "title": "组学时代直接心脏重编程综述发表", "date_start": "2026-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述总结组学时代直接心脏重编程的进展、机制与应用。", "summary": "组学工具让心脏重编程从经验驱动转向机制驱动。", "sources": [ "SRC-653" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程与年轻化", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-THT-212", "title": "病理过程中造血细胞命运重编程综述发表", "date_start": "2026-06-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论病理背景下造血细胞命运重编程与转化机会。", "summary": "造血系统重编程影响免疫重建和血液系统修复。", "sources": [ "SRC-654" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程与年轻化", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-THT-213", "title": "患者中心器官芯片模型框架发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该研究提出患者中心器官芯片模型框架。", "summary": "患者中心器官芯片把个体病理状态带入药物筛选。", "sources": [ "SRC-656" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片与类器官", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-print, year, v3)", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-214", "title": "眼部器官芯片系统演化综述发表", "date_start": "2025-07-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述总结眼部器官芯片在疾病建模和药物测试中的演化。", "summary": "眼部器官芯片为视觉功能保存提供高保真体外模型。", "sources": [ "SRC-657" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片与类器官", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-07-21 (published-online, day, v3)", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-215", "title": "器官芯片用于药物发现微生理系统综述发表", "date_start": "2026-02-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论器官芯片作为药物发现微生理系统的应用。", "summary": "微生理系统把药物测试从二维细胞推进到多器官耦合。", "sources": [ "SRC-658" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片与类器官", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-THT-216", "title": "器官芯片疾病建模与药物测试应用综述发表", "date_start": "2025-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述总结器官芯片在疾病建模和药物测试中的应用。", "summary": "器官芯片补充了动物模型与人体之间的人类相关性证据。", "sources": [ "SRC-659" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片与类器官", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-THT-217", "title": "器官芯片驱动药物开发变革综述发表", "date_start": "2025-01-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述讨论器官芯片在疾病建模和药物发现中的潜力。", "summary": "器官芯片正在成为药物发现流程中的标准候选工具。", "sources": [ "SRC-660" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片与类器官", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-THT-218", "title": "3D 蛋白质组学用于结构功能与生物标志发现发表", "date_start": "2026-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究提出 3D 蛋白质组学以进行结构、功能、化学和生物标志发现。", "summary": "结构级蛋白质组学把蛋白丰度测量扩展到构象变化。", "sources": [ "SRC-661" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质组与多组学", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-04 (published-print, month, v3)", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-136", "title": "GNPC 神经退行疾病蛋白质组资源发表", "date_start": "2025-07-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究发布 GNPC 蛋白质组资源，用于神经退行疾病生物标志发现。", "summary": "神经退行蛋白质组资源为脑健康监测提供分子基础。", "sources": [ "SRC-662" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质组与多组学", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-TEC-137", "title": "尿液蛋白质组识别不稳定颈动脉斑块非侵入性生物标志研究发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究通过尿液蛋白质组识别 ADAMDEC1 作为不稳定颈动脉斑块标志。", "summary": "非侵入性尿液标志可降低血管风险监测门槛。", "sources": [ "SRC-663" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质组与多组学", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-138", "title": "复合肽对敏感皮肤抗衰老作用与机制研究发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究分析复合肽对敏感皮肤的抗衰老作用与机制。", "summary": "肽类护肤干预是皮肤衰老维护的小分子工具。", "sources": [ "SRC-664" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质组与多组学", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-219", "title": "从表观标记检测到表观编辑策略理性设计综述发表", "date_start": "2026-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论从表观标记检测到表观编辑策略的理性设计。", "summary": "表观编辑需要先建立可检测、可归因的标记体系。", "sources": [ "SRC-665" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质组与多组学", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-08 (published-print, month, v3)", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-139", "title": "可解释机器学习预测抑郁和糖尿病研究发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究提出可解释机器学习方法预测抑郁和糖尿病。", "summary": "可解释预测让 AI 从黑盒输出进入临床信任链。", "sources": [ "SRC-666" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "可解释 AI 与临床决策", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-220", "title": "生成式 AI 应如何改变临床决策支持观点发表", "date_start": "2026-07-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该观点讨论生成式 AI 应如何改变临床决策支持。", "summary": "生成式 AI 进入临床需要重新设计证据检索、解释和责任链。", "sources": [ "SRC-668" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "可解释 AI 与临床决策", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-THT-221", "title": "AI 临床决策支持工具中的广告问题研究发表", "date_start": "2026-07-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究分析 AI 临床决策支持工具中的广告问题。", "summary": "商业化内容可能污染临床推荐，必须纳入独立治理。", "sources": [ "SRC-669" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "可解释 AI 与临床决策", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-TEC-141", "title": "老龄居住社区可持续景观再生 AI 决策支持研究发表", "date_start": "2026-07-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究提出用于老龄居住社区可持续景观再生的 AI 决策支持。", "summary": "建成环境再生需要把老年人需求与可持续发展纳入 AI 优化。", "sources": [ "SRC-670" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "可解释 AI 与临床决策", "notes": "第 111-115 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:29:57Z", "updated_at": "2026-08-06T16:29:57Z" }, { "event_id": "HIT-TEC-142", "title": "老年人心理韧性与社会支持、积极性和孤独关联研究发表", "date_start": "2026-07-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究分析老年人心理韧性与社会支持、积极性和孤独的关联。", "summary": "心理韧性是主体应对损失和不确定性的内部资源。", "sources": [ "SRC-671" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理健康与情绪韧性", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-THT-222", "title": "开罗老年难民流离失所中的韧性创伤与身份研究发表", "date_start": "2026-07-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该解释现象学研究分析开罗老年难民流离失所中的韧性、创伤与身份。", "summary": "迁移和创伤会重塑老年主体的身份连续性。", "sources": [ "SRC-672" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理健康与情绪韧性", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-TEC-143", "title": "年龄污名与晚年情绪隔离中介研究发表", "date_start": "2025-08-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究分析年龄污名通过自尊和衰老焦虑影响晚年情绪隔离。", "summary": "年龄污名是损害老年主体心理韧性的社会机制。", "sources": [ "SRC-673" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理健康与情绪韧性", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-08-07 (published-online, day, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-144", "title": "阿尔茨海默风险行为改变情境情绪反应研究发表", "date_start": "2026-06-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究分析老年受试者对不同程度阿尔茨海默风险行为改变情境的情绪反应。", "summary": "风险沟通必须考虑情绪成本和主体自主。", "sources": [ "SRC-674" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理健康与情绪韧性", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-THT-223", "title": "身体活动促进可持续健康老龄化的快乐老龄化观点发表", "date_start": "2026-01-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该观点讨论身体活动在可持续健康老龄化中的快乐作用。", "summary": "幸福感应成为健康老龄化的结果，而非附带品。", "sources": [ "SRC-675" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理健康与情绪韧性", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-THT-224", "title": "老年人身体活动干预评估方法与指标系统综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该系统综述总结老年人身体活动干预评估使用的方法和指标。", "summary": "统一评估指标是跨试验比较和证据复用的基础。", "sources": [ "SRC-676" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "身体活动与运动干预", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-print, year, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-145", "title": "祖孙共同身体活动代际干预开发研究发表", "date_start": "2026-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究开发并描述祖孙共同身体活动代际干预。", "summary": "代际共同活动同时增强社会支持与身体活动。", "sources": [ "SRC-677" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "身体活动与运动干预", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-TEC-146", "title": "游戏化数字身体活动干预自主动机随机试验发表", "date_start": "2026-04-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该随机试验检验自主动机作为游戏化数字身体活动干预的变化机制。", "summary": "动机机制解释干预为什么有效，而不仅是否有效。", "sources": [ "SRC-678" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "身体活动与运动干预", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-TEC-147", "title": "拉丁裔帕金森老年人远程身体活动试验招募研究发表", "date_start": "2025-12-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究分析拉丁裔帕金森老年人远程身体活动试验的招募。", "summary": "临床试验招募公平性决定证据是否覆盖真实主体群体。", "sources": [ "SRC-679" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "身体活动与运动干预", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-THT-225", "title": "力量训练与舞蹈训练随机试验勘误发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该勘误更新老年人力量训练与舞蹈训练对比随机试验的信息。", "summary": "科学记录必须保留修正痕迹，避免错误结论被引用。", "sources": [ "SRC-680" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "身体活动与运动干预", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-print, year, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-226", "title": "昼夜节律健康定义与指数框架发表", "date_start": "2026-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究提出昼夜节律健康概念框架并开发昼夜节律健康指数。", "summary": "昼夜节律健康成为可测量资源，为睡眠干预提供统一指标。", "sources": [ "SRC-681" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠与昼夜节律", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-04 (published-print, month, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-148", "title": "光暴露对睡眠和昼夜节律影响建模研究发表", "date_start": "2026-04-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究建模阳光和屏幕光暴露对睡眠与昼夜节律健康的关键时间窗口。", "summary": "光暴露时间比单纯“少用屏幕”更能指导行为。", "sources": [ "SRC-682" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠与昼夜节律", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-THT-227", "title": "褪黑素在昼夜节律与脑健康中的神经保护综述发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论褪黑素在昼夜节律和脑健康中的神经保护作用。", "summary": "褪黑素连接睡眠、节律和神经维护。", "sources": [ "SRC-683" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠与昼夜节律", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-149", "title": "Web3 去中心化睡眠昼夜节律健康数据共享系统发表", "date_start": "2026-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究提出 Web3 去中心化睡眠与昼夜节律健康数据共享系统。", "summary": "去中心化数据系统为个人睡眠数据提供新的所有权和共享边界。", "sources": [ "SRC-684" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠与昼夜节律", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-02 (published-print, month, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-150", "title": "估算心肺适能与昼夜节律综合征跨队列研究发表", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该跨队列研究分析估算心肺适能与昼夜节律综合征的关联。", "summary": "运动适能与节律健康相互强化，可成为联合干预目标。", "sources": [ "SRC-685" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠与昼夜节律", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-228", "title": "长期空气污染暴露与表观遗传时钟系统综述发表", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该系统综述和荟萃分析评估长期空气污染暴露与表观遗传时钟的关系。", "summary": "空气污染是加速生物衰老的外部环境变量。", "sources": [ "SRC-686" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "环境暴露与表观遗传", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-229", "title": "环境神经毒物诱发早衰脑表观机制综述发表", "date_start": "2026-06-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论环境神经毒物诱发早衰脑的分子、生化和表观机制。", "summary": "环境神经毒物直接威胁认知主体持续性的物质基础。", "sources": [ "SRC-687" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "环境暴露与表观遗传", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-TEC-151", "title": "出生时砷暴露与社会经济地位对成人表观衰老影响研究发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究分析出生时砷暴露和社会经济地位对成人表观衰老的影响。", "summary": "早期环境暴露与阶层结构共同写入生物年龄。", "sources": [ "SRC-688" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "环境暴露与表观遗传", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-152", "title": "宇航员作为人类衰老模型表观年龄响应研究发表", "date_start": "2026-01-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究把宇航员作为人类衰老模型分析太空暴露的表观年龄响应。", "summary": "极端环境暴露是理解快速生物衰老变化的自然实验。", "sources": [ "SRC-689" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "环境暴露与表观遗传", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01-11 (published-online, day, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-230", "title": "环境暴露表观修饰与不良妊娠结局系统综述发表", "date_start": "2026-05-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该系统综述讨论环境暴露诱导的表观修饰与不良妊娠结局。", "summary": "生命早期表观环境影响下一代主体持续性。", "sources": [ "SRC-690" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "环境暴露与表观遗传", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-TEC-153", "title": "美国心血管病与癌症并存死亡率趋势研究发表", "date_start": "2026-05-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究分析美国心血管病与癌症并存的死亡率趋势。", "summary": "多病共存趋势要求健康寿命模型超越单病种统计。", "sources": [ "SRC-691" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "人口统计与全球健康", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-TEC-154", "title": "1999-2023 年美国老年人骨关节炎死亡率趋势发表", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究分析 1999 至 2023 年美国老年人骨关节炎死亡率趋势。", "summary": "骨关节炎相关死亡体现活动能力损失对寿命的系统影响。", "sources": [ "SRC-692" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "人口统计与全球健康", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-155", "title": "积极老龄态度与十年死亡延迟人群研究发表", "date_start": "2026-05-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该人群研究显示积极老龄态度与十年后死亡延迟相关。", "summary": "态度和身份认同可能通过行为和生理路径影响寿命。", "sources": [ "SRC-693" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "人口统计与全球健康", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-THT-231", "title": "老年人数字金融包容趋势挑战与策略发表", "date_start": "2026-03-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究分析老年人数字金融包容的趋势、挑战与策略。", "summary": "金融基础设施可及性决定老年主体的资源选择权。", "sources": [ "SRC-694" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "人口统计与全球健康", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-THT-232", "title": "灾害与老龄化全球研究趋势发表", "date_start": "2026-03-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究梳理灾害与老龄化的全球研究趋势。", "summary": "灾害系统必须把老年人脆弱性和恢复能力纳入设计。", "sources": [ "SRC-695" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "人口统计与全球健康", "notes": "第 116-120 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:30:32Z", "updated_at": "2026-08-06T16:30:32Z" }, { "event_id": "HIT-TEC-156", "title": "《Selective tACS modulation of aperiodic EEG components》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究分析选择性经颅交流电刺激对非周期 EEG 成分的调节。", "summary": "神经调控机制研究为无创认知增强提供更精确的靶点。", "sources": [ "SRC-696" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经调控与脑机接口", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-157", "title": "《Understanding the neural pathways of trigeminal nerve stimulation》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究讨论三叉神经刺激的神经通路。", "summary": "外周神经刺激进入脑干和皮层网络的机制是神经调控基础。", "sources": [ "SRC-697" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经调控与脑机接口", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-158", "title": "《The modulation of spatiotemporal patterns of neural activity depend on…》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究分析直流电刺激频率对神经活动时空模式的影响。", "summary": "刺激频率是神经可塑性调节的关键参数。", "sources": [ "SRC-698" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经调控与脑机接口", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-159", "title": "《EEG-Based Evaluation of Brain Activity Modulation Through Deep Brain S…》论文发表", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究使用 EEG 评估帕金森病深脑刺激对脑活动的调节。", "summary": "闭环神经调控需要可测量的脑活动反馈。", "sources": [ "SRC-699" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经调控与脑机接口", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-233", "title": "《Hormonal modulation after deep brain stimulation and spinal cord stimu…》论文发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该范围综述讨论深脑刺激和脊髓刺激后的激素调节。", "summary": "神经调控除运动功能外还影响内分泌和主体生理状态。", "sources": [ "SRC-700" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经调控与脑机接口", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-160", "title": "《Senescence-associated secretory phenotype: the pathogenic factor drivi…》论文发表", "date_start": "2026-05-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究讨论 SASP 作为骨科退变驱动因素。", "summary": "SASP 把衰老细胞与组织退变连接，是 senolytic 干预的病理基础。", "sources": [ "SRC-701" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老与 SASP", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-05-18 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-161", "title": "《Proteostasis decline and endoplasmic reticulum stress in aging》论文发表", "date_start": "2025-08-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究讨论衰老中的蛋白稳态下降和内质网应激。", "summary": "蛋白稳态与内质网应激是细胞衰老上游机制。", "sources": [ "SRC-702" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老与 SASP", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-08-13 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-234", "title": "《Extracellular Vesicles as Key SASP Carriers Driving Cellular Senescenc…》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论胞外囊泡作为 SASP 关键载体。", "summary": "胞外囊泡是衰老信号在细胞间传播的介质。", "sources": [ "SRC-703" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老与 SASP", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-162", "title": "《The multifaceted inducers of cellular senescence》论文发表", "date_start": "2026-06-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究梳理细胞衰老的多方面诱因。", "summary": "单一诱因模型不足以描述细胞衰老。", "sources": [ "SRC-704" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老与 SASP", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06-22 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-235", "title": "《Inflammaging and Senescence-Associated Secretory Phenotype (SASP) in P…》论文发表", "date_start": "2026-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该叙述综述讨论银屑病中的炎症衰老与 SASP。", "summary": "皮肤系统是炎症衰老和 SASP 的重要暴露界面。", "sources": [ "SRC-705" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老与 SASP", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-05 (published-online, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-163", "title": "《Investigating the Potential of Gene Editing Technologies in Enhancing …》论文发表", "date_start": "2026-03-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究讨论基因编辑技术增强干细胞疗法的潜力。", "summary": "基因编辑与干细胞结合可提升组织修复的特异性。", "sources": [ "SRC-706" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因编辑与表观编辑", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03-31 (published-print, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-164", "title": "《Editing epigenetic age》论文发表", "date_start": "2025-06-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究讨论编辑表观遗传年龄的可能性与边界。", "summary": "表观年龄编辑是重编程和基因编辑交叉的核心议题。", "sources": [ "SRC-707" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因编辑与表观编辑", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-06-02 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-236", "title": "《Novel gene-editing technologies: applications of CRISPR-Cas9, base edi…》论文发表", "date_start": "2026-03-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "thought", "claim": "该综述总结 CRISPR-Cas9、碱基编辑和先导编辑的应用。", "summary": "新一代基因编辑工具扩展了可修复突变类型。", "sources": [ "SRC-708" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因编辑与表观编辑", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03-25 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-165", "title": "《Epigenetic editing to advance CAR T cell therapy》论文发表", "date_start": "2026-02-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究讨论表观编辑推进 CAR-T 细胞治疗。", "summary": "表观编辑可改善免疫细胞状态和持久性。", "sources": [ "SRC-709" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因编辑与表观编辑", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-02-23 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-FAI-013", "title": "《Gene Editing Pioneer Sangamo Files for Chapter 11 Bankruptcy》论文发表", "date_start": "2026-07-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "failure", "claim": "基因编辑先驱 Sangamo 申请第 11 章破产并同意出售资产。", "summary": "产业失败记录揭示基因编辑转化在资金、监管和临床结果上的现实约束。", "sources": [ "SRC-710" ], "evidence_grade": "L", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因编辑与表观编辑", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07-22 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-166", "title": "《Machine Perfusion Improves Organ Preservation for Transplant》论文发表", "date_start": "2025-02-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究讨论机器灌注改善移植器官保存。", "summary": "机器灌注是器官保存从静态冷藏转向动态维护的关键。", "sources": [ "SRC-711" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官保存与灌注", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-02-27 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-237", "title": "《The Current State of Organ Perfusion and Preservation: Lessons From th…》论文发表", "date_start": "2026-06-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "该综述总结世界移植大会关于器官灌注与保存的经验。", "summary": "国际会议共识为器官保存标准化提供参考。", "sources": [ "SRC-712" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官保存与灌注", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06-10 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-238", "title": "《Updates on Machine Perfusion for Organ Preservation: Highlights From t…》论文发表", "date_start": "2025-10-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "该综述更新世界移植大会机器灌注器官保存要点。", "summary": "机器灌注临床数据正在从研究走向常规流程。", "sources": [ "SRC-713" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官保存与灌注", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-10-28 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-167", "title": "《Characteristics and Outcomes of Combined Lung-Liver Transplant with or…》论文发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究分析联合肺肝移植及保存处理的特征与结局。", "summary": "多器官保存策略影响复杂移植结局。", "sources": [ "SRC-714" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官保存与灌注", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-239", "title": "《Response to Machine Perfusion Organ Preservation: Highlights From the …》论文发表", "date_start": "2025-06-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "该回应讨论美国移植大会机器灌注器官保存亮点。", "summary": "学术讨论记录有助于澄清灌注技术的适用范围。", "sources": [ "SRC-715" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官保存与灌注", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-06-19 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-168", "title": "《Supporting healthy ageing through community-based dietary education》论文发表", "date_start": "2026-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究讨论社区饮食教育支持健康老龄化。", "summary": "社区层面营养教育是饮食干预的可及路径。", "sources": [ "SRC-716" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养与饮食干预", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-08 (published-print, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-169", "title": "《The Relationship Between Receptivity to Questions about Dietary Just-i…》论文发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究分析对饮食即时自适应干预问题的接受度。", "summary": "数字营养干预需要把用户接受度纳入设计。", "sources": [ "SRC-717" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养与饮食干预", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-170", "title": "《Psychological attributes predict dietary pattern transitions in older …》论文发表", "date_start": "2026-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究发现心理属性预测老年人饮食模式转变。", "summary": "饮食行为改变受心理资源影响，不能只给信息。", "sources": [ "SRC-718" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养与饮食干预", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-08 (published-print, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-171", "title": "《Associations of dietary patterns with mild cognitive impairment in old…》论文发表", "date_start": "2026-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究分析新加坡老年人饮食模式与轻度认知障碍的关联。", "summary": "饮食模式是认知健康可干预的暴露因素。", "sources": [ "SRC-719" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养与饮食干预", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-08 (published-print, month, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-172", "title": "《Low muscle mass as an independent risk factor for 30-day mortality amo…》论文发表", "date_start": "2026-03-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该全国队列研究发现低肌肉量是老年吸入性肺炎住院患者 30 天死亡风险因素。", "summary": "肌肉量反映营养和恢复储备，是住院结局的关键变量。", "sources": [ "SRC-720" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养与饮食干预", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03-08 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-173", "title": "《Reversing Immune Aging to Improve Immunotherapy Outcomes》论文发表", "date_start": "2026-02-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究讨论逆转免疫衰老以改善免疫治疗结局。", "summary": "免疫衰老是免疫治疗疗效的重要系统限制。", "sources": [ "SRC-721" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫疗法与疫苗", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-02-24 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-174", "title": "《Anti-Tumor Immunotherapy of Scutellaria Baicalensis-Derived Vesicles o…》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究检验黄芩来源囊泡在免疫检查点抗肿瘤免疫中的作用。", "summary": "植物来源囊泡是新型免疫调节候选工具。", "sources": [ "SRC-722" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫疗法与疫苗", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-240", "title": "《Metabolism of Young and Aged Hematopoietic and Acute Myeloid Leukemia …》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该综述讨论年轻和衰老造血干细胞及急性髓系白血病干细胞的代谢。", "summary": "代谢状态决定造血和白血病干细胞的治疗响应。", "sources": [ "SRC-723" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫疗法与疫苗", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-175", "title": "《Clonal hematopoiesis boosts response to immune checkpoint therapy》论文发表", "date_start": "2026-02-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究发现克隆性造血增强免疫检查点治疗响应。", "summary": "血液克隆状态可能成为免疫治疗预测标志。", "sources": [ "SRC-724" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫疗法与疫苗", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-02-12 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-241", "title": "《Considerations on Heterochronic Plasma Transfer in Aging Research》论文发表", "date_start": "2026-03-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究讨论异时血浆转移在衰老研究中的考虑。", "summary": "血浆交换作为年轻化实验路径需要严格区分机制与效果。", "sources": [ "SRC-725" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫疗法与疫苗", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03-09 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-242", "title": "《Methods and Safety of Exercise Testing in Older Adults: A Narrative Re…》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该叙述综述总结老年人运动测试的方法与安全。", "summary": "安全运动评估是老年人运动干预的入口。", "sources": [ "SRC-726" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动与康复", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-176", "title": "《Effects of an Exercise-Assisting Mobile App for Osteoarthritis Rehabil…》论文发表", "date_start": "2026-04-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究评估运动辅助手机应用用于骨关节炎康复的效果。", "summary": "数字运动工具可扩展康复可及性。", "sources": [ "SRC-727" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动与康复", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-04-15 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-177", "title": "《The Benefits of a Digital Exercise Intervention for Older Adults: Fitt…》论文发表", "date_start": "2026-01-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该随机试验评估 Fittle 数字运动干预对老年人的益处。", "summary": "随机证据支持数字运动干预作为常规运动补充。", "sources": [ "SRC-728" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动与康复", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-06T16:33:41Z" }, { "event_id": "HIT-THT-243", "title": "《Can Older Adults Become Exercise Junkies? Commentary on Exercise Addic…》论文发表", "date_start": "2026-03-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该评论讨论老年人是否可能形成运动成瘾。", "summary": "运动干预需要同时关注获益与过度行为风险。", "sources": [ "SRC-729" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动与康复", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03-05 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-178", "title": "《Effects of Commercial Exergames vs. Traditional Indoor Exercise on Moo…》论文发表", "date_start": "2026-05-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该随机对照试验比较商业体感游戏与传统室内运动对老年人情绪的影响。", "summary": "体感游戏可能提高运动参与和情绪收益。", "sources": [ "SRC-730" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动与康复", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-06T16:33:41Z" }, { "event_id": "HIT-TEC-179", "title": "《Do ecosystem improvements enhance the cognitive function of older adul…》论文发表", "date_start": "2026-06-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该准实验研究评估生态系统改善对老年人认知功能的影响。", "summary": "建成环境改善可作为群体认知干预。", "sources": [ "SRC-731" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与心理健康", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-06-27 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-180", "title": "《Perceived age discrimination and cognitive function in older Korean ad…》论文发表", "date_start": "2026-03-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该横断面研究分析韩国老年人感知年龄歧视与认知功能的关系。", "summary": "年龄歧视是社会性认知风险因素。", "sources": [ "SRC-732" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与心理健康", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-03-14 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-181", "title": "《Self-perceptions of aging and cognitive function: mediating role of vo…》论文发表", "date_start": "2025-11-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究分析老龄自我认知通过志愿服务影响认知功能。", "summary": "社会参与是认知维护的可干预中介。", "sources": [ "SRC-733" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与心理健康", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-11-11 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-182", "title": "《The effects of social isolation and loneliness on cognitive function i…》论文发表", "date_start": "2026-01-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究分析社会隔离和孤独对老年人认知功能的影响。", "summary": "孤独是社会基础设施缺口，也是认知风险。", "sources": [ "SRC-734" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与心理健康", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01-19 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-183", "title": "《Cognitive function and its change over time: effects on depression tra…》论文发表", "date_start": "2026-01-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究分析认知功能及其变化对最老老年人抑郁轨迹的影响。", "summary": "认知和情绪是双向耦合的主体状态变量。", "sources": [ "SRC-735" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与心理健康", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01-13 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-244", "title": "《Balancing privacy and explainability in AI: Differential privacy and g…》论文发表", "date_start": "2026-05-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究讨论差分隐私和图论作为 AI 治理工具。", "summary": "隐私与可解释性需要联合设计而非二选一。", "sources": [ "SRC-736" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据治理与隐私", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-05-31 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-245", "title": "《Data privacy in the health AI era》论文发表", "date_start": "2026-07-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究讨论健康 AI 时代的数据隐私。", "summary": "健康 AI 的数据隐私是主体权利和模型信任的前提。", "sources": [ "SRC-737" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据治理与隐私", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07-29 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-246", "title": "《AI governance and data privacy in cross-border contexts: comparative a…》论文发表", "date_start": "2025-09-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究比较分析跨境 AI 治理与数据隐私。", "summary": "跨境数据流动需要治理互操作而非单一规则。", "sources": [ "SRC-738" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据治理与隐私", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2025-09-01 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-247", "title": "《From property to power: Why governance, not ownership, will define per…》论文发表", "date_start": "2026-05-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究主张个人数据由治理而非所有权定义。", "summary": "数据治理决定主体对自身数据的实际控制力。", "sources": [ "SRC-739" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据治理与隐私", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-05-31 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-248", "title": "《A Privacy-First Governance Architecture for Compliant Generative AI Da…》论文发表", "date_start": "2026-01-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究提出隐私优先的生成式 AI 数据管线治理架构。", "summary": "生成式 AI 数据管线需要把隐私治理内建到架构。", "sources": [ "SRC-740" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据治理与隐私", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-01-07 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-249", "title": "《Psychedelics and longevity: implications for lifespan, healthspan and …》论文发表", "date_start": "2026-07-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究讨论致幻剂对寿命、健康寿命和功能衰老的影响。", "summary": "精神活性物质进入长寿研究需要谨慎区分效应和风险。", "sources": [ "SRC-741" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "全球长寿产业与政策", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-07-05 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-250", "title": "《Psilocybin and human longevity》论文发表", "date_start": "2026-04-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该研究讨论裸盖菇素与人类长寿的关系。", "summary": "从动物延寿到人类长寿之间仍存在证据缺口。", "sources": [ "SRC-742" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "全球长寿产业与政策", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026-04-03 (published-online, day, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-251", "title": "《Brain Aging and the Pursuit of Longevity: Biological Mechanisms and Cl…》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该综述讨论脑衰老与长寿追求的生物学机制和临床含义。", "summary": "长寿必须把脑健康作为不可替代的主体条件。", "sources": [ "SRC-743" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "全球长寿产业与政策", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-184", "title": "《Leveraging transcriptome-based biological aging clocks and mRNA signat…》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究利用转录组生物年龄时钟和 mRNA 特征开发长寿疗法。", "summary": "转录组时钟可作为长寿药物开发的早期响应标志。", "sources": [ "SRC-744" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "medium", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "全球长寿产业与政策", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-252", "title": "《A Unified Longevity-Financial Risk Framework for Evaluating Pension Fu…》论文发表", "date_start": "2026-06-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究提出统一长寿金融风险框架评估养老金资金比率。", "summary": "长寿延长必须纳入金融和制度可持续性建模。", "sources": [ "SRC-745" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "全球长寿产业与政策", "notes": "第 121-130 轮精选批次：Crossref/DOI 核验；待本地复核。", "created_at": "2026-08-06T16:33:41Z", "updated_at": "2026-08-06T16:33:41Z" }, { "event_id": "HIT-TEC-185", "title": "《Circadian rhythm analysis using wearable-based accelerometry as a digital biomarker of aging and healthspan》论文发表", "date_start": "2024-06-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕衰老生物标志物验证报告可复核的分子或临床证据，为年龄状态测量提供方法输入。", "summary": "该节点将衰老生物标志物验证的最新学术证据纳入有效永生研究年表。", "sources": [ "SRC-746" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；生物标志物需跨队列验证。", "cross_links": [], "chapter": "衰老测量与生物年龄", "notes": "第 131 轮补录：衰老生物标志物验证；待本地复核。；日期补齐：Crossref 2024-06-04 (published-online, day, v3)", "created_at": "2026-08-06T16:49:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-186", "title": "《Quantification of healthspan in aging mice: introducing FAMY and GRAIL》论文发表", "date_start": "2024-05-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕衰老生物标志物验证报告可复核的分子或临床证据，为年龄状态测量提供方法输入。", "summary": "该节点将衰老生物标志物验证的最新学术证据纳入有效永生研究年表。", "sources": [ "SRC-747" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；生物标志物需跨队列验证。", "cross_links": [], "chapter": "衰老测量与生物年龄", "notes": "第 131 轮补录：衰老生物标志物验证；待本地复核。；日期补齐：Crossref 2024-05-17 (published-online, day, v3)", "created_at": "2026-08-06T16:49:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-187", "title": "《Hallmarks of aging: middle-aging hypovascularity, tissue perfusion and nitric oxide perspective on healthspan》论文发表", "date_start": "2025-01-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕衰老生物标志物验证报告可复核的分子或临床证据，为年龄状态测量提供方法输入。", "summary": "该节点将衰老生物标志物验证的最新学术证据纳入有效永生研究年表。", "sources": [ "SRC-748" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；生物标志物需跨队列验证。", "cross_links": [], "chapter": "衰老测量与生物年龄", "notes": "第 131 轮补录：衰老生物标志物验证；待本地复核。；日期补齐：Crossref 2025-01-07 (published-online, day, v3)", "created_at": "2026-08-06T16:49:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-188", "title": "《Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species》论文发表", "date_start": "2025-03-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕衰老生物标志物验证报告可复核的分子或临床证据，为年龄状态测量提供方法输入。", "summary": "该节点将衰老生物标志物验证的最新学术证据纳入有效永生研究年表。", "sources": [ "SRC-749" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；生物标志物需跨队列验证。", "cross_links": [], "chapter": "衰老测量与生物年龄", "notes": "第 131 轮补录：衰老生物标志物验证；待本地复核。；日期补齐：Crossref 2025-03-31 (published-online, day, v3)", "created_at": "2026-08-06T16:49:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-189", "title": "《Multimodal clocks of human aging》论文发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕衰老生物标志物验证报告可复核的分子或临床证据，为年龄状态测量提供方法输入。", "summary": "该节点将衰老生物标志物验证的最新学术证据纳入有效永生研究年表。", "sources": [ "SRC-750" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；生物标志物需跨队列验证。", "cross_links": [], "chapter": "衰老测量与生物年龄", "notes": "第 131 轮补录：衰老生物标志物验证；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-06T16:49:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-190", "title": "《Deep Brain Stimulation: From Antidepressants to Memory Enhancement》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕神经调控与记忆增强报告神经调控对记忆或认知功能的实验证据。", "summary": "该节点将神经调控与记忆增强的最新进展纳入认知增强路径。", "sources": [ "SRC-751" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；效应需独立复现。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 132 轮补录：神经调控与记忆增强；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-06T16:49:45Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-191", "title": "《Computational memory capacity predicts aging and cognitive decline》论文发表", "date_start": "2025-03-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕神经调控与记忆增强报告神经调控对记忆或认知功能的实验证据。", "summary": "该节点将神经调控与记忆增强的最新进展纳入认知增强路径。", "sources": [ "SRC-752" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；效应需独立复现。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 132 轮补录：神经调控与记忆增强；待本地复核。；日期补齐：Crossref 2025-03-20 (published-online, day, v3)", "created_at": "2026-08-06T16:49:45Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-192", "title": "《Cellular senescence in brain aging and cognitive decline》论文发表", "date_start": "2023-11-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕神经调控与记忆增强报告神经调控对记忆或认知功能的实验证据。", "summary": "该节点将神经调控与记忆增强的最新进展纳入认知增强路径。", "sources": [ "SRC-753" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；效应需独立复现。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 132 轮补录：神经调控与记忆增强；待本地复核。；日期补齐：Crossref 2023-11-23 (published-online, day, v3)", "created_at": "2026-08-06T16:49:45Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-194", "title": "《Pairing non-invasive brain stimulation with memory reactivation: rapid learning (and unlearning) in the human brain》论文发表", "date_start": "2023-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕神经调控与记忆增强报告神经调控对记忆或认知功能的实验证据。", "summary": "该节点将神经调控与记忆增强的最新进展纳入认知增强路径。", "sources": [ "SRC-755" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；效应需独立复现。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 132 轮补录：神经调控与记忆增强；待本地复核。；日期补齐：Crossref 2023-01 (published-print, month, v3)", "created_at": "2026-08-06T16:49:45Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-195", "title": "《Mitochondrial-derived vesicles in metabolism, disease, and aging》论文发表", "date_start": "2024-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕线粒体与代谢重编程报告线粒体或代谢状态对衰老进程的影响证据。", "summary": "该节点将线粒体与代谢重编程的最新机制证据纳入主体持续性维护路径。", "sources": [ "SRC-756" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；代谢干预存在种属差异。", "cross_links": [], "chapter": "衰老机制、能量代谢与长寿干预", "notes": "第 133 轮补录：线粒体与代谢重编程；待本地复核。；日期补齐：Crossref 2024-01 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-196", "title": "《Mitochondrial GTP metabolism controls reproductive aging in C. elegans》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕线粒体与代谢重编程报告线粒体或代谢状态对衰老进程的影响证据。", "summary": "该节点将线粒体与代谢重编程的最新机制证据纳入主体持续性维护路径。", "sources": [ "SRC-757" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；代谢干预存在种属差异。", "cross_links": [], "chapter": "衰老机制、能量代谢与长寿干预", "notes": "第 133 轮补录：线粒体与代谢重编程；待本地复核。；日期补齐：Crossref 2023-12 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-197", "title": "《The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕线粒体与代谢重编程报告线粒体或代谢状态对衰老进程的影响证据。", "summary": "该节点将线粒体与代谢重编程的最新机制证据纳入主体持续性维护路径。", "sources": [ "SRC-758" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；代谢干预存在种属差异。", "cross_links": [], "chapter": "衰老机制、能量代谢与长寿干预", "notes": "第 133 轮补录：线粒体与代谢重编程；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-198", "title": "《Unraveling the interplay between sleep, redox metabolism, and aging: implications for brain health and longevity》论文发表", "date_start": "2025-05-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕线粒体与代谢重编程报告线粒体或代谢状态对衰老进程的影响证据。", "summary": "该节点将线粒体与代谢重编程的最新机制证据纳入主体持续性维护路径。", "sources": [ "SRC-759" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；代谢干预存在种属差异。", "cross_links": [], "chapter": "衰老机制、能量代谢与长寿干预", "notes": "第 133 轮补录：线粒体与代谢重编程；待本地复核。；日期补齐：Crossref 2025-05-21 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-199", "title": "《The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging》论文发表", "date_start": "2023-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕线粒体与代谢重编程报告线粒体未折叠蛋白反应对海马神经干细胞衰老的调控证据。", "summary": "该节点将线粒体未折叠蛋白反应纳入神经干细胞维持路径。", "sources": [ "SRC-760" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老机制、能量代谢与长寿干预", "notes": "第 133 轮补录：线粒体与代谢重编程；待本地复核。；日期补齐：Crossref 2023-06 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-200", "title": "《Conquering aging-related immunosenescence and tumor immune escape》论文发表", "date_start": "2026-03-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕免疫衰老与疫苗接种报告免疫衰老或疫苗响应机制的证据。", "summary": "该节点将免疫衰老与疫苗接种的最新证据纳入免疫维护路径。", "sources": [ "SRC-761" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫系统维护与感染韧性", "notes": "第 134 轮补录：免疫衰老与疫苗接种；待本地复核。；日期补齐：Crossref 2026-03-10 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-201", "title": "《Immunosenescence in prostate cancer: from aging-related immune dysfunction to therapeutic opportunities》论文发表", "date_start": "2026-07-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕免疫衰老与疫苗接种报告免疫衰老或疫苗响应机制的证据。", "summary": "该节点将免疫衰老与疫苗接种的最新证据纳入免疫维护路径。", "sources": [ "SRC-762" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫系统维护与感染韧性", "notes": "第 134 轮补录：免疫衰老与疫苗接种；待本地复核。；日期补齐：Crossref 2026-07-23 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-202", "title": "《The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience》论文发表", "date_start": "2024-10-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕免疫衰老与疫苗接种报告免疫衰老或疫苗响应机制的证据。", "summary": "该节点将免疫衰老与疫苗接种的最新证据纳入免疫维护路径。", "sources": [ "SRC-763" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫系统维护与感染韧性", "notes": "第 134 轮补录：免疫衰老与疫苗接种；待本地复核。；日期补齐：Crossref 2024-10-16 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-203", "title": "《CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline》论文发表", "date_start": "2023-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕免疫衰老与疫苗接种报告免疫衰老或疫苗响应机制的证据。", "summary": "该节点将免疫衰老与疫苗接种的最新证据纳入免疫维护路径。", "sources": [ "SRC-764" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫系统维护与感染韧性", "notes": "第 134 轮补录：免疫衰老与疫苗接种；待本地复核。；日期补齐：Crossref 2023-10 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-204", "title": "《Immune Resilience: Rewriting the Rules of Healthy Aging》论文发表", "date_start": "2025-04-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕免疫衰老与疫苗接种报告免疫衰老或疫苗响应机制的证据。", "summary": "该节点将免疫衰老与疫苗接种的最新证据纳入免疫维护路径。", "sources": [ "SRC-765" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫系统维护与感染韧性", "notes": "第 134 轮补录：免疫衰老与疫苗接种；待本地复核。；日期补齐：Crossref 2025-04-30 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-205", "title": "《A human autoimmune organoid model reveals IL-7 function in coeliac disease》论文发表", "date_start": "2024-07-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕类器官与器官芯片报告可替代或模拟器官功能的研究模型。", "summary": "该节点将类器官与器官芯片的最新进展纳入器官重建路径。", "sources": [ "SRC-766" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；体外模型不能直接等同于人体功能。", "cross_links": [], "chapter": "器官重建、类器官与微生理系统", "notes": "第 135 轮补录：类器官与器官芯片；待本地复核。；日期补齐：Crossref 2024-07-24 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-206", "title": "《Advances in Biliary Disease Organoid Research: From Model Construction to Clinical Applications》论文发表", "date_start": "2025-07-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕类器官与器官芯片报告可替代或模拟器官功能的研究模型。", "summary": "该节点将类器官与器官芯片的最新进展纳入器官重建路径。", "sources": [ "SRC-767" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；体外模型不能直接等同于人体功能。", "cross_links": [], "chapter": "器官重建、类器官与微生理系统", "notes": "第 135 轮补录：类器官与器官芯片；待本地复核。；日期补齐：Crossref 2025-07-17 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-207", "title": "《Optimization of Vascularized Intestinal Organoid Model》论文发表", "date_start": "2024-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕类器官与器官芯片报告可替代或模拟器官功能的研究模型。", "summary": "该节点将类器官与器官芯片的最新进展纳入器官重建路径。", "sources": [ "SRC-768" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；体外模型不能直接等同于人体功能。", "cross_links": [], "chapter": "器官重建、类器官与微生理系统", "notes": "第 135 轮补录：类器官与器官芯片；待本地复核。；日期补齐：Crossref 2024-08 (published-online, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-208", "title": "《Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging》论文发表", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕类器官与器官芯片报告可替代或模拟器官功能的研究模型。", "summary": "该节点将类器官与器官芯片的最新进展纳入器官重建路径。", "sources": [ "SRC-769" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；体外模型不能直接等同于人体功能。", "cross_links": [], "chapter": "器官重建、类器官与微生理系统", "notes": "第 135 轮补录：类器官与器官芯片；待本地复核。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-209", "title": "《Understanding Immune-Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform》论文发表", "date_start": "2022-07-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕类器官与器官芯片报告脑类器官微生理平台用于免疫驱动脑衰老研究。", "summary": "该节点将脑类器官微生理平台纳入衰老机制建模路径。", "sources": [ "SRC-770" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官重建、类器官与微生理系统", "notes": "第 135 轮补录：类器官与器官芯片；待本地复核。；日期补齐：Crossref 2022-07-31 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-210", "title": "《Stem Cell Aging and Rejuvenation in the Skeletal Muscle System》论文发表", "date_start": "2025-07-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕干细胞与再生医学报告干细胞或再生策略对组织维持的影响。", "summary": "该节点将干细胞与再生医学的最新证据纳入再生修复路径。", "sources": [ "SRC-771" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程、再生医学与临床转化", "notes": "第 136 轮补录：干细胞与再生医学；待本地复核。；日期补齐：Crossref 2025-07-29 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-211", "title": "《Brain aging and rejuvenation at single-cell resolution》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕干细胞与再生医学报告干细胞或再生策略对组织维持的影响。", "summary": "该节点将干细胞与再生医学的最新证据纳入再生修复路径。", "sources": [ "SRC-772" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程、再生医学与临床转化", "notes": "第 136 轮补录：干细胞与再生医学；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-212", "title": "《Hallmarks of stem cell aging》论文发表", "date_start": "2025-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕干细胞与再生医学报告干细胞或再生策略对组织维持的影响。", "summary": "该节点将干细胞与再生医学的最新证据纳入再生修复路径。", "sources": [ "SRC-773" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程、再生医学与临床转化", "notes": "第 136 轮补录：干细胞与再生医学；待本地复核。；日期补齐：Crossref 2025-07 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-213", "title": "《DNA methylation controls hematopoietic stem cell aging》论文发表", "date_start": "2023-10-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕干细胞与再生医学报告干细胞或再生策略对组织维持的影响。", "summary": "该节点将干细胞与再生医学的最新证据纳入再生修复路径。", "sources": [ "SRC-774" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程、再生医学与临床转化", "notes": "第 136 轮补录：干细胞与再生医学；待本地复核。；日期补齐：Crossref 2023-10-26 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-214", "title": "《Trained immunity links hematopoietic stem cell aging to aging-associated inflammation》论文发表", "date_start": "2026-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕干细胞与再生医学报告干细胞或再生策略对组织维持的影响。", "summary": "该节点将干细胞与再生医学的最新证据纳入再生修复路径。", "sources": [ "SRC-775" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程、再生医学与临床转化", "notes": "第 136 轮补录：干细胞与再生医学；待本地复核。；日期补齐：Crossref 2026-07-16 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-215", "title": "《Developing physical protocols for human organ scale vitrification and rewarming》论文发表", "date_start": "2024-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕低温保存与玻璃化报告低温保存或玻璃化方法的可复核结果。", "summary": "该节点将低温保存与玻璃化的最新证据纳入生物停滞路径。", "sources": [ "SRC-776" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；低温保存不等同于复活。", "cross_links": [], "chapter": "低温保存、生物停滞与未来选择权", "notes": "第 137 轮补录：低温保存与玻璃化；待本地复核。；日期补齐：Crossref 2024-12 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-216", "title": "《Organ cryopreservation by vitrification and rapid rewarming: new breakthroughs in transplantation》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕低温保存与玻璃化报告低温保存或玻璃化方法的可复核结果。", "summary": "该节点将低温保存与玻璃化的最新证据纳入生物停滞路径。", "sources": [ "SRC-777" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；低温保存不等同于复活。", "cross_links": [], "chapter": "低温保存、生物停滞与未来选择权", "notes": "第 137 轮补录：低温保存与玻璃化；待本地复核。；日期补齐：Crossref 2023-12 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-217", "title": "《IS OVARIAN TISSUE CRYOPRESERVATION WIDELY ACCESSIBLE?》论文发表", "date_start": "2025-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕低温保存与玻璃化报告低温保存或玻璃化方法的可复核结果。", "summary": "该节点将低温保存与玻璃化的最新证据纳入生物停滞路径。", "sources": [ "SRC-778" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；低温保存不等同于复活。", "cross_links": [], "chapter": "低温保存、生物停滞与未来选择权", "notes": "第 137 轮补录：低温保存与玻璃化；待本地复核。；日期补齐：Crossref 2025-07 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-218", "title": "《Clinical dilemmas in ovarian tissue cryopreservation》论文发表", "date_start": "2024-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕低温保存与玻璃化报告低温保存或玻璃化方法的可复核结果。", "summary": "该节点将低温保存与玻璃化的最新证据纳入生物停滞路径。", "sources": [ "SRC-779" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；低温保存不等同于复活。", "cross_links": [], "chapter": "低温保存、生物停滞与未来选择权", "notes": "第 137 轮补录：低温保存与玻璃化；待本地复核。；日期补齐：Crossref 2024-10 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-219", "title": "《ASSESSING KNOWLEDGE AMONG OVARIAN TISSUE CRYOPRESERVATION PATIENTS》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕低温保存与玻璃化报告低温保存或玻璃化方法的可复核结果。", "summary": "该节点将低温保存与玻璃化的最新证据纳入生物停滞路径。", "sources": [ "SRC-780" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；低温保存不等同于复活。", "cross_links": [], "chapter": "低温保存、生物停滞与未来选择权", "notes": "第 137 轮补录：低温保存与玻璃化；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-220", "title": "《Towards a multi-organ, multi-omics medical digital twin》论文发表", "date_start": "2025-08-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与个体化健康建模提出多器官多组学医学数字孪生架构。", "summary": "该节点将多器官多组学数字孪生纳入可计算主体模型路径。", "sources": [ "SRC-781" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、个体建模与预测医学", "notes": "第 138 轮补录：数字孪生与个体化健康建模；待本地复核。；日期补齐：Crossref 2025-08-25 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-222", "title": "《Digital twin for personalized medicine development》论文发表", "date_start": "2025-08-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与个体化健康建模讨论数字孪生用于个性化医学开发的路径。", "summary": "该节点将数字孪生纳入个性化医学开发路径。", "sources": [ "SRC-783" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、个体建模与预测医学", "notes": "第 138 轮补录：数字孪生与个体化健康建模；待本地复核。；日期补齐：Crossref 2025-08-07 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-223", "title": "《Digital twin technologies in prostate cancer as a frontier for precision medicine》论文发表", "date_start": "2026-06-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕数字孪生与个体化健康建模报告前列腺癌数字孪生用于精准医学的进展。", "summary": "该节点将癌症数字孪生纳入疾病预测与个体建模路径。", "sources": [ "SRC-784" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、个体建模与预测医学", "notes": "第 138 轮补录：数字孪生与个体化健康建模；待本地复核。；日期补齐：Crossref 2026-06-19 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-224", "title": "《Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective》论文发表", "date_start": "2025-07-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与个体化健康建模提出患者数字孪生与仿生孪生整合视角。", "summary": "该节点将患者数字孪生与仿生模型整合纳入精准医学路径。", "sources": [ "SRC-785" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、个体建模与预测医学", "notes": "第 138 轮补录：数字孪生与个体化健康建模；待本地复核。；日期补齐：Crossref 2025-07-23 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-225", "title": "《Artificial intelligence in drug discovery》论文发表", "date_start": "2026-06-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕AI 药物发现与临床转化报告 AI 驱动的药物发现或临床转化证据。", "summary": "该节点将AI 药物发现与临床转化的最新进展纳入 AI 加速科学路径。", "sources": [ "SRC-786" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 自动化科学、药物发现与临床转化", "notes": "第 139 轮补录：AI 药物发现与临床转化；待本地复核。；日期补齐：Crossref 2026-06-16 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-226", "title": "《Artificial intelligence for natural product drug discovery》论文发表", "date_start": "2023-09-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕AI 药物发现与临床转化报告 AI 驱动的药物发现或临床转化证据。", "summary": "该节点将AI 药物发现与临床转化的最新进展纳入 AI 加速科学路径。", "sources": [ "SRC-787" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 自动化科学、药物发现与临床转化", "notes": "第 139 轮补录：AI 药物发现与临床转化；待本地复核。；日期补齐：Crossref 2023-09-11 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-227", "title": "《Physics-based machine learning for enhanced drug formulation development》论文发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕AI 药物发现与临床转化报告 AI 驱动的药物发现或临床转化证据。", "summary": "该节点将AI 药物发现与临床转化的最新进展纳入 AI 加速科学路径。", "sources": [ "SRC-788" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 自动化科学、药物发现与临床转化", "notes": "第 139 轮补录：AI 药物发现与临床转化；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-228", "title": "《Machine learning models for drug-drug interaction prediction from computational discovery to clinical application》论文发表", "date_start": "2026-01-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕AI 药物发现与临床转化报告 AI 驱动的药物发现或临床转化证据。", "summary": "该节点将AI 药物发现与临床转化的最新进展纳入 AI 加速科学路径。", "sources": [ "SRC-789" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 自动化科学、药物发现与临床转化", "notes": "第 139 轮补录：AI 药物发现与临床转化；待本地复核。；日期补齐：Crossref 2026-01-29 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-229", "title": "《Deep learning in image-based phenotypic drug discovery》论文发表", "date_start": "2023-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕AI 药物发现与临床转化报告 AI 驱动的药物发现或临床转化证据。", "summary": "该节点将AI 药物发现与临床转化的最新进展纳入 AI 加速科学路径。", "sources": [ "SRC-790" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 自动化科学、药物发现与临床转化", "notes": "第 139 轮补录：AI 药物发现与临床转化；待本地复核。；日期补齐：Crossref 2023-07 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-253", "title": "《The role of quality of life data as an endpoint for collecting real-world evidence within geroscience clinical trials》论文发表", "date_start": "2024-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿医学监管与终点设计讨论试验终点、监管路径或临床评估方法。", "summary": "该节点将长寿医学监管与终点设计的治理与方法进展纳入长寿医学制度路径。", "sources": [ "SRC-791" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "第 140 轮补录：长寿医学监管与终点设计；待本地复核。；日期补齐：Crossref 2024-06 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-254", "title": "《NIA Translational Geroscience Network: An infrastructure to facilitate geroscience‐guided clinical trials》论文发表", "date_start": "2024-04-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿医学监管与终点设计讨论试验终点、监管路径或临床评估方法。", "summary": "该节点将长寿医学监管与终点设计的治理与方法进展纳入长寿医学制度路径。", "sources": [ "SRC-792" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "第 140 轮补录：长寿医学监管与终点设计；待本地复核。；日期补齐：Crossref 2024-04-22 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-255", "title": "《Geroscience》论文发表", "date_start": "2025-09-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿医学监管与终点设计讨论老年科学在临床医学中的定位。", "summary": "该节点将老年科学的临床定位纳入长寿医学制度路径。", "sources": [ "SRC-793" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "第 140 轮补录：长寿医学监管与终点设计；待本地复核。；日期补齐：Crossref 2025-09-23 (published-print, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-256", "title": "《Advancing Geroscience Research - A Scoping Review of Regulatory Environments for Gerotherapeutics》论文发表", "date_start": "2025-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿医学监管与终点设计综述长寿干预药物的监管环境。", "summary": "该节点将 gerotherapeutics 监管环境纳入长寿医学制度路径。", "sources": [ "SRC-794" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "第 140 轮补录：长寿医学监管与终点设计；待本地复核。；日期补齐：Crossref 2025-09 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-230", "title": "《An epigenetic clock in plants》论文发表", "date_start": "2023-09-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕表观遗传时钟跨人群验证报告年龄时钟在队列或人群中的验证结果。", "summary": "该节点将表观遗传时钟跨人群验证的最新证据纳入衰老测量基础设施。", "sources": [ "SRC-796" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "第 141 轮补录：表观遗传时钟跨人群验证；待本地复核。；日期补齐：Crossref 2023-09-29 (published-print, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-231", "title": "《Epigenetic clock work ticks forward》论文发表", "date_start": "2024-01-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕表观遗传时钟跨人群验证报告年龄时钟在队列或人群中的验证结果。", "summary": "该节点将表观遗传时钟跨人群验证的最新证据纳入衰老测量基础设施。", "sources": [ "SRC-797" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "第 141 轮补录：表观遗传时钟跨人群验证；待本地复核。；日期补齐：Crossref 2024-01-30 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-232", "title": "《An evolutionary epigenetic clock in plants》论文发表", "date_start": "2023-09-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕表观遗传时钟跨人群验证报告年龄时钟在队列或人群中的验证结果。", "summary": "该节点将表观遗传时钟跨人群验证的最新证据纳入衰老测量基础设施。", "sources": [ "SRC-798" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "第 141 轮补录：表观遗传时钟跨人群验证；待本地复核。；日期补齐：Crossref 2023-09-29 (published-print, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-233", "title": "《Efficient epigenetic clock measurements with TIME-seq》论文发表", "date_start": "2024-01-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕表观遗传时钟跨人群验证报告年龄时钟在队列或人群中的验证结果。", "summary": "该节点将表观遗传时钟跨人群验证的最新证据纳入衰老测量基础设施。", "sources": [ "SRC-799" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "第 141 轮补录：表观遗传时钟跨人群验证；待本地复核。；日期补齐：Crossref 2024-01-15 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-234", "title": "《Epigenetic Clock Analysis of Sex Chromosome Aneuploidies》论文发表", "date_start": "2025-09-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕表观遗传时钟跨人群验证报告年龄时钟在队列或人群中的验证结果。", "summary": "该节点将表观遗传时钟跨人群验证的最新证据纳入衰老测量基础设施。", "sources": [ "SRC-800" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "第 141 轮补录：表观遗传时钟跨人群验证；待本地复核。；日期补齐：Crossref 2025-09-30 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-235", "title": "《Astrocytic proteostasis in the tale of aging and neurodegeneration》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕蛋白质稳态与自噬报告蛋白质质量控制或自噬机制对衰老的影响。", "summary": "该节点将蛋白质稳态与自噬的最新机制证据纳入细胞维护路径。", "sources": [ "SRC-801" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态、自噬与细胞质量控制", "notes": "第 142 轮补录：蛋白质稳态与自噬；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-236", "title": "《Autophagy, aging, and age-related neurodegeneration》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕蛋白质稳态与自噬报告蛋白质质量控制或自噬机制对衰老的影响。", "summary": "该节点将蛋白质稳态与自噬的最新机制证据纳入细胞维护路径。", "sources": [ "SRC-802" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态、自噬与细胞质量控制", "notes": "第 142 轮补录：蛋白质稳态与自噬；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-237", "title": "《Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease》论文发表", "date_start": "2023-11-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕蛋白质稳态与自噬报告蛋白质质量控制或自噬机制对衰老的影响。", "summary": "该节点将蛋白质稳态与自噬的最新机制证据纳入细胞维护路径。", "sources": [ "SRC-803" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态、自噬与细胞质量控制", "notes": "第 142 轮补录：蛋白质稳态与自噬；待本地复核。；日期补齐：Crossref 2023-11-02 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-238", "title": "《Karyopherins in proteostasis and aging》论文发表", "date_start": "2026-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕蛋白质稳态与自噬报告蛋白质质量控制或自噬机制对衰老的影响。", "summary": "该节点将蛋白质稳态与自噬的最新机制证据纳入细胞维护路径。", "sources": [ "SRC-804" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态、自噬与细胞质量控制", "notes": "第 142 轮补录：蛋白质稳态与自噬；待本地复核。；日期补齐：Crossref 2026-08 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-239", "title": "《Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo》论文发表", "date_start": "2025-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕蛋白质稳态与自噬报告蛋白质质量控制或自噬机制对衰老的影响。", "summary": "该节点将蛋白质稳态与自噬的最新机制证据纳入细胞维护路径。", "sources": [ "SRC-805" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态、自噬与细胞质量控制", "notes": "第 142 轮补录：蛋白质稳态与自噬；待本地复核。；日期补齐：Crossref 2025-10 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-240", "title": "《Senolytics target cellular senescence — but can they slow aging?》论文发表", "date_start": "2024-09-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕细胞衰老清除与 senolytics报告衰老细胞清除策略的机制或临床前证据。", "summary": "该节点将细胞衰老清除与 senolytics的最新证据纳入细胞衰老控制路径。", "sources": [ "SRC-806" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、SASP 与 senolytics", "notes": "第 143 轮补录：细胞衰老清除与 senolytics；待本地复核。；日期补齐：Crossref 2024-09-02 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-241", "title": "《Aging, Cellular Senescence, and Glaucoma》论文发表", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕细胞衰老清除与 senolytics报告衰老细胞清除策略的机制或临床前证据。", "summary": "该节点将细胞衰老清除与 senolytics的最新证据纳入细胞衰老控制路径。", "sources": [ "SRC-807" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、SASP 与 senolytics", "notes": "第 143 轮补录：细胞衰老清除与 senolytics；待本地复核。；日期补齐：Crossref 2023 (published-print, year, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-242", "title": "《Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics》论文发表", "date_start": "2023-01-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕细胞衰老清除与 senolytics报告衰老细胞清除策略的机制或临床前证据。", "summary": "该节点将细胞衰老清除与 senolytics的最新证据纳入细胞衰老控制路径。", "sources": [ "SRC-808" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、SASP 与 senolytics", "notes": "第 143 轮补录：细胞衰老清除与 senolytics；待本地复核。；日期补齐：Crossref 2023-01-17 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-243", "title": "《Sex, senescence, senolytics, and cognition》论文发表", "date_start": "2025-03-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕细胞衰老清除与 senolytics报告衰老细胞清除策略的机制或临床前证据。", "summary": "该节点将细胞衰老清除与 senolytics的最新证据纳入细胞衰老控制路径。", "sources": [ "SRC-809" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、SASP 与 senolytics", "notes": "第 143 轮补录：细胞衰老清除与 senolytics；待本地复核。；日期补齐：Crossref 2025-03-04 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-244", "title": "《Cellular senescence in brain aging and neurodegeneration》论文发表", "date_start": "2024-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕细胞衰老清除与 senolytics报告衰老细胞清除策略的机制或临床前证据。", "summary": "该节点将细胞衰老清除与 senolytics的最新证据纳入细胞衰老控制路径。", "sources": [ "SRC-810" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、SASP 与 senolytics", "notes": "第 143 轮补录：细胞衰老清除与 senolytics；待本地复核。；日期补齐：Crossref 2024-01 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-245", "title": "《Unlocking Naturalistic Speech With Brain‐Computer Interface》论文发表", "date_start": "2025-05-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口与言语解码报告脑机接口或言语解码的实验证据。", "summary": "该节点将脑机接口与言语解码的最新进展纳入认知外延与行动恢复路径。", "sources": [ "SRC-811" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、言语解码与运动重建", "notes": "第 144 轮补录：脑机接口与言语解码；待本地复核。；日期补齐：Crossref 2025-05-12 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-246", "title": "《An EEG-EMG-Based Hybrid Brain–Computer Interface for Decoding Tones in Silent and Audible Speech》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口与言语解码报告脑机接口或言语解码的实验证据。", "summary": "该节点将脑机接口与言语解码的最新进展纳入认知外延与行动恢复路径。", "sources": [ "SRC-812" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、言语解码与运动重建", "notes": "第 144 轮补录：脑机接口与言语解码；待本地复核。；日期补齐：Crossref 2025 (published-print, year, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-247", "title": "《Real-time decoding of full-spectrum Chinese using brain-computer interface》论文发表", "date_start": "2025-11-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口与言语解码报告脑机接口或言语解码的实验证据。", "summary": "该节点将脑机接口与言语解码的最新进展纳入认知外延与行动恢复路径。", "sources": [ "SRC-813" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、言语解码与运动重建", "notes": "第 144 轮补录：脑机接口与言语解码；待本地复核。；日期补齐：Crossref 2025-11-07 (published-print, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-248", "title": "《Cross-subject decoding of human neural data for speech brain computer interfaces》论文发表", "date_start": "2026-07-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口与言语解码报告脑机接口或言语解码的实验证据。", "summary": "该节点将脑机接口与言语解码的最新进展纳入认知外延与行动恢复路径。", "sources": [ "SRC-814" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、言语解码与运动重建", "notes": "第 144 轮补录：脑机接口与言语解码；待本地复核。；日期补齐：Crossref 2026-07-14 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-249", "title": "《Decoding cortical responses from visual input using an endovascular brain–computer interface》论文发表", "date_start": "2025-05-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口与言语解码报告脑机接口或言语解码的实验证据。", "summary": "该节点将脑机接口与言语解码的最新进展纳入认知外延与行动恢复路径。", "sources": [ "SRC-815" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、言语解码与运动重建", "notes": "第 144 轮补录：脑机接口与言语解码；待本地复核。；日期补齐：Crossref 2025-05-30 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-250", "title": "《Emerging Iontronic Neural Devices for Neuromorphic Sensory Computing》论文发表", "date_start": "2023-08-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "technology", "claim": "该研究围绕神经形态计算与活性算力报告神经形态硬件或生物神经元计算平台的证据。", "summary": "该节点将神经形态计算与活性算力的最新进展纳入智能迁移路径。", "sources": [ "SRC-816" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经形态计算、活性算力与合成智能", "notes": "第 145 轮补录：神经形态计算与活性算力；待本地复核。；日期补齐：Crossref 2023-08-02 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-251", "title": "《Neuromorphic computing paradigms enhance robustness through spiking neural networks》论文发表", "date_start": "2025-11-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "technology", "claim": "该研究围绕神经形态计算与活性算力报告神经形态硬件或生物神经元计算平台的证据。", "summary": "该节点将神经形态计算与活性算力的最新进展纳入智能迁移路径。", "sources": [ "SRC-817" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经形态计算、活性算力与合成智能", "notes": "第 145 轮补录：神经形态计算与活性算力；待本地复核。；日期补齐：Crossref 2025-11-19 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-252", "title": "《Oscillatory Neural Network with Tunable Frequency for Brain-Inspired Neuromorphic Computing》论文发表", "date_start": "2025-04-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "technology", "claim": "该研究围绕神经形态计算与活性算力报告神经形态硬件或生物神经元计算平台的证据。", "summary": "该节点将神经形态计算与活性算力的最新进展纳入智能迁移路径。", "sources": [ "SRC-818" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经形态计算、活性算力与合成智能", "notes": "第 145 轮补录：神经形态计算与活性算力；待本地复核。；日期补齐：Crossref 2025-04-16 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-253", "title": "《Biocomputing with organoid intelligence》论文发表", "date_start": "2024-05-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "technology", "claim": "该研究围绕神经形态计算与活性算力报告神经形态硬件或生物神经元计算平台的证据。", "summary": "该节点将神经形态计算与活性算力的最新进展纳入智能迁移路径。", "sources": [ "SRC-819" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经形态计算、活性算力与合成智能", "notes": "第 145 轮补录：神经形态计算与活性算力；待本地复核。；日期补齐：Crossref 2024-05-24 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-254", "title": "《Brain organoid reservoir computing for artificial intelligence》论文发表", "date_start": "2023-12-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "technology", "claim": "该研究围绕神经形态计算与活性算力报告神经形态硬件或生物神经元计算平台的证据。", "summary": "该节点将神经形态计算与活性算力的最新进展纳入智能迁移路径。", "sources": [ "SRC-820" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经形态计算、活性算力与合成智能", "notes": "第 145 轮补录：神经形态计算与活性算力；待本地复核。；日期补齐：Crossref 2023-12-11 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-255", "title": "《Oral delivery of nanomedicine for genetic kidney disease》论文发表", "date_start": "2024-05-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕纳米医学与药物递送报告纳米递送或分子级修复系统的证据。", "summary": "该节点将纳米医学与药物递送的最新进展纳入分子修复路径。", "sources": [ "SRC-821" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学、递送系统与分子修复", "notes": "第 146 轮补录：纳米医学与药物递送；待本地复核。；日期补齐：Crossref 2024-05-10 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-256", "title": "《Music enhances lipid nanoparticle brain delivery and mRNA transfection in brain cells》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕纳米医学与药物递送报告纳米递送或分子级修复系统的证据。", "summary": "该节点将纳米医学与药物递送的最新进展纳入分子修复路径。", "sources": [ "SRC-822" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学、递送系统与分子修复", "notes": "第 146 轮补录：纳米医学与药物递送；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-257", "title": "《H-ferritin nanoparticle-mediated antibody delivery across the blood-brain barrier》论文发表", "date_start": "2026-06-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕纳米医学与药物递送报告纳米递送或分子级修复系统的证据。", "summary": "该节点将纳米医学与药物递送的最新进展纳入分子修复路径。", "sources": [ "SRC-823" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学、递送系统与分子修复", "notes": "第 146 轮补录：纳米医学与药物递送；待本地复核。；日期补齐：Crossref 2026-06-03 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-258", "title": "《Ionic Liquid Coating‐Driven Nanoparticle Delivery to the Brain: Applications for NeuroHIV》论文发表", "date_start": "2024-04-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕纳米医学与药物递送报告纳米递送或分子级修复系统的证据。", "summary": "该节点将纳米医学与药物递送的最新进展纳入分子修复路径。", "sources": [ "SRC-824" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学、递送系统与分子修复", "notes": "第 146 轮补录：纳米医学与药物递送；待本地复核。；日期补齐：Crossref 2024-04-04 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-259", "title": "《Intracerebral Nanoparticle Transport Facilitated by Alzheimer Pathology and Age》论文发表", "date_start": "2023-11-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕纳米医学与药物递送报告阿尔茨海默病理与年龄对脑内纳米颗粒转运的影响。", "summary": "该节点将年龄依赖的脑内纳米递送纳入分子修复路径。", "sources": [ "SRC-825" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学、递送系统与分子修复", "notes": "第 146 轮补录：纳米医学与药物递送；待本地复核。；日期补齐：Crossref 2023-11-22 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-260", "title": "《Bioprinted Scaffold Remodels the Neuromodulatory Microenvironment for Enhancing Bone Regeneration》论文发表", "date_start": "2023-05-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕生物打印与器官重建报告生物打印支架重塑神经调控微环境促进骨再生。", "summary": "该节点将生物打印支架纳入组织重建路径。", "sources": [ "SRC-826" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物打印、组织工程与器官重建", "notes": "第 147 轮补录：生物打印与器官重建；待本地复核。；日期补齐：Crossref 2023-05-31 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-261", "title": "《A 3D bioprinted adhesive tissue engineering scaffold to repair ischemic heart injury》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕生物打印与器官重建报告黏附性三维生物打印支架修复缺血性心脏损伤。", "summary": "该节点将心脏生物打印支架纳入器官重建路径。", "sources": [ "SRC-827" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物打印、组织工程与器官重建", "notes": "第 147 轮补录：生物打印与器官重建；待本地复核。；日期补齐：Crossref 2025 (published-online, year, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-262", "title": "《3D bioprinting of emulating homeostasis regulation for regenerative medicine applications》论文发表", "date_start": "2023-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕生物打印与器官重建报告模拟稳态调控的三维生物打印应用。", "summary": "该节点将稳态调控生物打印纳入再生医学路径。", "sources": [ "SRC-828" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物打印、组织工程与器官重建", "notes": "第 147 轮补录：生物打印与器官重建；待本地复核。；日期补齐：Crossref 2023-01 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-263", "title": "《Advances in 3D bioprinting for regenerative medicine applications》论文发表", "date_start": "2024-03-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕生物打印与器官重建综述三维生物打印在再生医学中的进展。", "summary": "该节点将再生医学生物打印综述纳入组织重建路径。", "sources": [ "SRC-829" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物打印、组织工程与器官重建", "notes": "第 147 轮补录：生物打印与器官重建；待本地复核。；日期补齐：Crossref 2024-03-26 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-264", "title": "《3D bioprinted organ-on-chips》论文发表", "date_start": "2022-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕生物打印与器官重建报告三维生物打印器官芯片的构建与应用。", "summary": "该节点将生物打印器官芯片纳入器官重建与体外模型路径。", "sources": [ "SRC-830" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物打印、组织工程与器官重建", "notes": "第 147 轮补录：生物打印与器官重建；待本地复核。；日期补齐：Crossref 2022-05 (published-online, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-265", "title": "《Milestones on the path to clinical pig organ xenotransplantation》论文发表", "date_start": "2023-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕异种移植与器官可及性报告异种移植或器官可及性的证据。", "summary": "该节点将异种移植与器官可及性的最新进展纳入器官来源扩展路径。", "sources": [ "SRC-831" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、器官保存与组织重建", "notes": "第 148 轮补录：异种移植与器官可及性；待本地复核。；日期补齐：Crossref 2023-03 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-266", "title": "《Is Allosensitization Detrimental to Pig Organ Xenotransplantation, and Is Xenosensitization Detrimental to Subsequent Organ Allotransplantation? A Debate Organized by the International Xenotransplantation Association (IXA)》论文发表", "date_start": "2024-10-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕异种移植与器官可及性报告异种移植或器官可及性的证据。", "summary": "该节点将异种移植与器官可及性的最新进展纳入器官来源扩展路径。", "sources": [ "SRC-832" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、器官保存与组织重建", "notes": "第 148 轮补录：异种移植与器官可及性；待本地复核。；日期补齐：Crossref 2024-10-15 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-267", "title": "《Proteomic Insights Into Organ-Specific and Shared Dynamics in Pig-to-Human Xenotransplantation》论文发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕异种移植与器官可及性报告异种移植或器官可及性的证据。", "summary": "该节点将异种移植与器官可及性的最新进展纳入器官来源扩展路径。", "sources": [ "SRC-833" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、器官保存与组织重建", "notes": "第 148 轮补录：异种移植与器官可及性；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-268", "title": "《Renin‐Angiotensin‐Aldosterone System (RAAS) in Pig‐to‐Baboon Kidney Xenotransplantation—Relevance to Clinical Pig Kidney Xenotransplantation》论文发表", "date_start": "2026-04-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕异种移植与器官可及性报告异种移植或器官可及性的证据。", "summary": "该节点将异种移植与器官可及性的最新进展纳入器官来源扩展路径。", "sources": [ "SRC-834" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、器官保存与组织重建", "notes": "第 148 轮补录：异种移植与器官可及性；待本地复核。；日期补齐：Crossref 2026-04-14 (published-online, day, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-269", "title": "《Gene-Edited Pig Kidney Xenotransplants in Humans: Record Survival and Mechanistic Insights》论文发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕异种移植与器官可及性报告异种移植或器官可及性的证据。", "summary": "该节点将异种移植与器官可及性的最新进展纳入器官来源扩展路径。", "sources": [ "SRC-835" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、器官保存与组织重建", "notes": "第 148 轮补录：异种移植与器官可及性；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:49:46Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-270", "title": "《FERTILITY BENEFIT SATISFACTION IN THE PHYSICIAN WORKFORCE: THE IMPACT OF EMPLOYER FERTILITY AND OOCYTE CRYOPRESERVATION COVERAGE》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕生殖保存与未来选择权报告配子、卵巢或生育力保存的证据。", "summary": "该节点将生殖保存与未来选择权的最新进展纳入未来选择权路径。", "sources": [ "SRC-836" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖保存、生育力与未来选择权", "notes": "第 149 轮补录：生殖保存与未来选择权；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-06T16:49:47Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-271", "title": "《OOCYTE CRYOPRESERVATION OUTCOMES IN ONCOFERTILITY PATIENTS COMPARED TO THOSE UNDERGOING PLANNED OOCYTE CRYOPRESERVATION》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕生殖保存与未来选择权报告配子、卵巢或生育力保存的证据。", "summary": "该节点将生殖保存与未来选择权的最新进展纳入未来选择权路径。", "sources": [ "SRC-837" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖保存、生育力与未来选择权", "notes": "第 149 轮补录：生殖保存与未来选择权；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-06T16:49:47Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-272", "title": "《P-398 Elective Oocyte Cryopreservation – a viable alternative as a means of fertility preservation》论文发表", "date_start": "2023-06-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕生殖保存与未来选择权报告配子、卵巢或生育力保存的证据。", "summary": "该节点将生殖保存与未来选择权的最新进展纳入未来选择权路径。", "sources": [ "SRC-838" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖保存、生育力与未来选择权", "notes": "第 149 轮补录：生殖保存与未来选择权；待本地复核。；日期补齐：Crossref 2023-06-22 (published-online, day, v3)", "created_at": "2026-08-06T16:49:47Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-273", "title": "《Oocyte cryopreservation for fertility preservation in transgender and gender diverse individuals: a SWOT analysis》论文发表", "date_start": "2025-07-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕生殖保存与未来选择权报告配子、卵巢或生育力保存的证据。", "summary": "该节点将生殖保存与未来选择权的最新进展纳入未来选择权路径。", "sources": [ "SRC-839" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖保存、生育力与未来选择权", "notes": "第 149 轮补录：生殖保存与未来选择权；待本地复核。；日期补齐：Crossref 2025-07-28 (published-online, day, v3)", "created_at": "2026-08-06T16:49:47Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-274", "title": "《Is planned oocyte cryopreservation delivering?》论文发表", "date_start": "2025-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕生殖保存与未来选择权报告配子、卵巢或生育力保存的证据。", "summary": "该节点将生殖保存与未来选择权的最新进展纳入未来选择权路径。", "sources": [ "SRC-840" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖保存、生育力与未来选择权", "notes": "第 149 轮补录：生殖保存与未来选择权；待本地复核。；日期补齐：Crossref 2025-04 (published-print, month, v3)", "created_at": "2026-08-06T16:49:47Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-275", "title": "《Network statistics of the whole-brain connectome of Drosophila》论文发表", "date_start": "2024-10-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕脑保存与连接组报告脑保存或连接组重建的证据。", "summary": "该节点将脑保存与连接组的最新进展纳入脑保存与数字迁移路径。", "sources": [ "SRC-841" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存、连接组与数字迁移", "notes": "第 150 轮补录：脑保存与连接组；待本地复核。；日期补齐：Crossref 2024-10-02 (published-online, day, v3)", "created_at": "2026-08-06T16:49:47Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-276", "title": "《Whole-brain phenotype mapping between humans and mice》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕脑保存与连接组报告脑保存或连接组重建的证据。", "summary": "该节点将脑保存与连接组的最新进展纳入脑保存与数字迁移路径。", "sources": [ "SRC-842" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存、连接组与数字迁移", "notes": "第 150 轮补录：脑保存与连接组；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-06T16:49:47Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-277", "title": "《Brain-wide neuronal circuit connectome of human glioblastoma》论文发表", "date_start": "2025-01-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕脑保存与连接组报告脑保存或连接组重建的证据。", "summary": "该节点将脑保存与连接组的最新进展纳入脑保存与数字迁移路径。", "sources": [ "SRC-843" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存、连接组与数字迁移", "notes": "第 150 轮补录：脑保存与连接组；待本地复核。；日期补齐：Crossref 2025-01-16 (published-online, day, v3)", "created_at": "2026-08-06T16:49:47Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-279", "title": "《Optimization of Brain Tissue Preservation for Nucleic Acid Stability》论文发表", "date_start": "2026-01-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕脑保存与连接组报告脑组织保存方法对核酸稳定性的优化。", "summary": "该节点将脑组织核酸保存优化纳入脑保存路径。", "sources": [ "SRC-845" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存、连接组与数字迁移", "notes": "第 150 轮补录：脑保存与连接组；待本地复核。；日期补齐：Crossref 2026-01-05 (published-online, day, v3)", "created_at": "2026-08-06T16:49:47Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-258", "title": "《Clinical research on extreme longevity: The FACET experience》论文发表", "date_start": "2024-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿产业资金与转化组织分析资金、产业组织或转化路径对长寿研究的影响。", "summary": "该节点将长寿产业资金与转化组织的最新证据纳入长寿产业与制度路径。", "sources": [ "SRC-846" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；产业资金信息易快速变化。", "cross_links": [], "chapter": "长寿产业资金网络与转化组织", "notes": "第 151 轮补录：长寿产业资金与转化组织；待本地复核。；日期补齐：Crossref 2024-01 (published-print, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-259", "title": "《Mucosal TLR5 activation controls healthspan and longevity》论文发表", "date_start": "2024-01-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿产业资金与转化组织分析资金、产业组织或转化路径对长寿研究的影响。", "summary": "该节点将长寿产业资金与转化组织的最新证据纳入长寿产业与制度路径。", "sources": [ "SRC-847" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；产业资金信息易快速变化。", "cross_links": [], "chapter": "长寿产业资金网络与转化组织", "notes": "第 151 轮补录：长寿产业资金与转化组织；待本地复核。；日期补齐：Crossref 2024-01-02 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-260", "title": "《Isoleucine dietary restriction boosts healthspan and longevity in mice》论文发表", "date_start": "2023-12-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿产业资金与转化组织分析资金、产业组织或转化路径对长寿研究的影响。", "summary": "该节点将长寿产业资金与转化组织的最新证据纳入长寿产业与制度路径。", "sources": [ "SRC-848" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；产业资金信息易快速变化。", "cross_links": [], "chapter": "长寿产业资金网络与转化组织", "notes": "第 151 轮补录：长寿产业资金与转化组织；待本地复核。；日期补齐：Crossref 2023-12-06 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-261", "title": "《Defining a longevity biotechnology company》论文发表", "date_start": "2023-06-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿产业资金与转化组织分析资金、产业组织或转化路径对长寿研究的影响。", "summary": "该节点将长寿产业资金与转化组织的最新证据纳入长寿产业与制度路径。", "sources": [ "SRC-849" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；产业资金信息易快速变化。", "cross_links": [], "chapter": "长寿产业资金网络与转化组织", "notes": "第 151 轮补录：长寿产业资金与转化组织；待本地复核。；日期补齐：Crossref 2023-06-26 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-262", "title": "《The Longevity Med Summit: insights on healthspan from cell to society》论文发表", "date_start": "2024-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿产业资金与转化组织分析资金、产业组织或转化路径对长寿研究的影响。", "summary": "该节点将长寿产业资金与转化组织的最新证据纳入长寿产业与制度路径。", "sources": [ "SRC-850" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核；产业资金信息易快速变化。", "cross_links": [], "chapter": "长寿产业资金网络与转化组织", "notes": "第 151 轮补录：长寿产业资金与转化组织；待本地复核。；日期补齐：Crossref 2024-07-16 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-263", "title": "《Enabling translational geroscience by broadening the scope of geriatric care》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿转化研究基础设施讨论扩大老年医学范围以推动转化老年科学。", "summary": "该节点将转化老年科学与老年医学整合纳入研究基础设施路径。", "sources": [ "SRC-851" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿转化研究、资助与临床基础设施", "notes": "第 152 轮补录：长寿转化研究基础设施；待本地复核。；日期补齐：Crossref 2023-12 (published-online, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-264", "title": "《Artificial intelligence across the aging continuum: Mechanistic geroscience, therapeutic innovation, and clinical impact》论文发表", "date_start": "2026-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿转化研究基础设施讨论人工智能贯穿衰老连续体的转化作用。", "summary": "该节点将 AI 与老年科学转化纳入研究基础设施路径。", "sources": [ "SRC-852" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿转化研究、资助与临床基础设施", "notes": "第 152 轮补录：长寿转化研究基础设施；待本地复核。；日期补齐：Crossref 2026-08 (published-print, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-265", "title": "《Translational Geroscience Strategies for Delaying Multimorbidity》论文发表", "date_start": "2026-03-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿转化研究基础设施提出延缓多重疾病的转化老年科学策略。", "summary": "该节点将多重疾病延缓策略纳入长寿转化研究路径。", "sources": [ "SRC-853" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿转化研究、资助与临床基础设施", "notes": "第 152 轮补录：长寿转化研究基础设施；待本地复核。；日期补齐：Crossref 2026-03-16 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-266", "title": "《Translational Geroscience: Human Models of Healthy Aging and Longevity》论文发表", "date_start": "2021-12-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿转化研究基础设施讨论健康衰老与长寿的人类模型。", "summary": "该节点将人类衰老模型纳入转化老年科学路径。", "sources": [ "SRC-854" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿转化研究、资助与临床基础设施", "notes": "第 152 轮补录：长寿转化研究基础设施；待本地复核。；日期补齐：Crossref 2021-12-17 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-267", "title": "《Aging Cell and the growing pains of translational geroscience》论文发表", "date_start": "2023-01-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿转化研究基础设施讨论转化老年科学发展的阶段性挑战。", "summary": "该节点将转化老年科学的发展挑战纳入研究基础设施路径。", "sources": [ "SRC-855" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿转化研究、资助与临床基础设施", "notes": "第 152 轮补录：长寿转化研究基础设施；待本地复核。；日期补齐：Crossref 2023-01-12 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-280", "title": "《Novel AIRTrode-based wearable electrode supports long-term, online brain–computer interface operations》论文发表", "date_start": "2025-01-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口长期随访与居家使用报告长期使用、随访或临床转化的证据。", "summary": "该节点将脑机接口长期随访与居家使用的最新证据纳入脑机接口临床路径。", "sources": [ "SRC-856" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、长期随访与神经权利", "notes": "第 153 轮补录：脑机接口长期随访与居家使用；待本地复核。；日期补齐：Crossref 2025-01-07 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-281", "title": "《Brain-computer interface commercialization》论文发表", "date_start": "2026-01-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口长期随访与居家使用报告长期使用、随访或临床转化的证据。", "summary": "该节点将脑机接口长期随访与居家使用的最新证据纳入脑机接口临床路径。", "sources": [ "SRC-857" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、长期随访与神经权利", "notes": "第 153 轮补录：脑机接口长期随访与居家使用；待本地复核。；日期补齐：Crossref 2026-01-29 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-282", "title": "《An Interventional Brain-Computer Interface for Long-Term EEG Collection and Motion Classification of a Quadruped Mammal》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口长期随访与居家使用报告长期使用、随访或临床转化的证据。", "summary": "该节点将脑机接口长期随访与居家使用的最新证据纳入脑机接口临床路径。", "sources": [ "SRC-858" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、长期随访与神经权利", "notes": "第 153 轮补录：脑机接口长期随访与居家使用；待本地复核。；日期补齐：Crossref 2025 (published-print, year, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-283", "title": "《Visual tracking brain-computer interface》论文发表", "date_start": "2024-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口长期随访与居家使用报告长期使用、随访或临床转化的证据。", "summary": "该节点将脑机接口长期随访与居家使用的最新证据纳入脑机接口临床路径。", "sources": [ "SRC-859" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、长期随访与神经权利", "notes": "第 153 轮补录：脑机接口长期随访与居家使用；待本地复核。；日期补齐：Crossref 2024-04 (published-print, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-284", "title": "《Intracortical brain-computer interface for navigation in virtual reality in macaque monkeys》论文发表", "date_start": "2026-04-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口长期随访与居家使用报告长期使用、随访或临床转化的证据。", "summary": "该节点将脑机接口长期随访与居家使用的最新证据纳入脑机接口临床路径。", "sources": [ "SRC-860" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、长期随访与神经权利", "notes": "第 153 轮补录：脑机接口长期随访与居家使用；待本地复核。；日期补齐：Crossref 2026-04-17 (published-print, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-285", "title": "《Discovery of tunable and soluble organic emitters for solid-state lasers with a self-driving laboratory》论文发表", "date_start": "2026-02-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕AI 自动化科研与材料发现报告自主实验、AI 代理或自动化科研的证据。", "summary": "该节点将AI 自动化科研与材料发现的最新进展纳入 AI 自动化科学路径。", "sources": [ "SRC-861" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 自动化科学、技术与知识基础设施", "notes": "第 154 轮补录：AI 自动化科研与材料发现；待本地复核。；日期补齐：Crossref 2026-02-19 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-286", "title": "《Digital twins for self-driving chemistry laboratories》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕 AI 自动化科研与材料发现报告自驱动化学实验室数字孪生。", "summary": "该节点将自驱动实验室数字孪生纳入 AI 自动化科研路径。", "sources": [ "SRC-862" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 自动化科学、技术与知识基础设施", "notes": "第 154 轮补录：AI 自动化科研与材料发现；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-287", "title": "《Autonomous experimentation systems for materials development: A community perspective》论文发表", "date_start": "2021-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕 AI 自动化科研与材料发现讨论材料开发自主实验系统的社区视角。", "summary": "该节点将自主实验系统纳入材料发现基础设施路径。", "sources": [ "SRC-863" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 自动化科学、技术与知识基础设施", "notes": "第 154 轮补录：AI 自动化科研与材料发现；待本地复核。；日期补齐：Crossref 2021-09 (published-print, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-288", "title": "《Self-Driving Laboratory for Polymer Electronics》论文发表", "date_start": "2023-03-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕 AI 自动化科研与材料发现报告聚合物电子材料自驱动实验室。", "summary": "该节点将聚合物材料自驱动实验室纳入 AI 自动化科研路径。", "sources": [ "SRC-864" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 自动化科学、技术与知识基础设施", "notes": "第 154 轮补录：AI 自动化科研与材料发现；待本地复核。；日期补齐：Crossref 2023-03-09 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-289", "title": "《A review of large language models and autonomous agents in chemistry》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕 AI 自动化科研与材料发现综述大语言模型和化学自主代理。", "summary": "该节点将 LLM 化学代理纳入 AI 自动化科研路径。", "sources": [ "SRC-865" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 自动化科学、技术与知识基础设施", "notes": "第 154 轮补录：AI 自动化科研与材料发现；待本地复核。；日期补齐：Crossref 2025 (published-online, year, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-290", "title": "《SECOND-GENERATION SPERM EPIGENETIC CLOCK ESTIMATES SPERM BIOLOGICAL AGE AND PREDICTS TIME-TO-PREGNANCY IN A GENERAL POPULATION COHORT》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕生物年龄跨人群校准报告跨队列或跨人群的生物年龄测量结果。", "summary": "该节点将生物年龄跨人群校准的最新证据纳入衰老测量基础设施。", "sources": [ "SRC-866" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "第 155 轮补录：生物年龄跨人群校准；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-291", "title": "《Biological age construction for prediction of mortality in the Chinese population》论文发表", "date_start": "2025-03-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕生物年龄跨人群校准报告跨队列或跨人群的生物年龄测量结果。", "summary": "该节点将生物年龄跨人群校准的最新证据纳入衰老测量基础设施。", "sources": [ "SRC-867" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "第 155 轮补录：生物年龄跨人群校准；待本地复核。；日期补齐：Crossref 2025-03-28 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-292", "title": "《Difference between Biological Age and Chronological Age Predicts Mortality and Hospitalization in a Longitudinal Adult Cohort》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕生物年龄跨人群校准报告跨队列或跨人群的生物年龄测量结果。", "summary": "该节点将生物年龄跨人群校准的最新证据纳入衰老测量基础设施。", "sources": [ "SRC-868" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "第 155 轮补录：生物年龄跨人群校准；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-293", "title": "《Associations between shift work and biological age acceleration: A population-based study》论文发表", "date_start": "2025-03-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕生物年龄跨人群校准报告跨队列或跨人群的生物年龄测量结果。", "summary": "该节点将生物年龄跨人群校准的最新证据纳入衰老测量基础设施。", "sources": [ "SRC-869" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "第 155 轮补录：生物年龄跨人群校准；待本地复核。；日期补齐：Crossref 2025-03-01 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-294", "title": "《Biological age acceleration, longitudinal change and mortality risk in the Dutch Lifelines cohort》论文发表", "date_start": "2026-04-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕生物年龄跨人群校准报告跨队列或跨人群的生物年龄测量结果。", "summary": "该节点将生物年龄跨人群校准的最新证据纳入衰老测量基础设施。", "sources": [ "SRC-870" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老测量、生物年龄与健康寿命", "notes": "第 155 轮补录：生物年龄跨人群校准；待本地复核。；日期补齐：Crossref 2026-04-14 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-268", "title": "《Ethics need to keep up with human brain organoid research》论文发表", "date_start": "2024-09-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕活性算力与合成智能治理讨论活性算力或合成智能的伦理、治理与边界。", "summary": "该节点将活性算力与合成智能治理的最新讨论纳入合成智能治理路径。", "sources": [ "SRC-871" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经形态计算、活性算力与合成智能", "notes": "第 156 轮补录：活性算力与合成智能治理；待本地复核。；日期补齐：Crossref 2024-09-12 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-269", "title": "《Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish》论文发表", "date_start": "2023-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕活性算力与合成智能治理提出类器官智能作为生物计算新前沿。", "summary": "该节点将类器官智能概念纳入活性算力路径。", "sources": [ "SRC-872" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经形态计算、活性算力与合成智能", "notes": "第 156 轮补录：活性算力与合成智能治理；待本地复核。；日期补齐：Crossref 2023-02-28 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-270", "title": "《The Ethics of Human Brain Organoid Transplantation in Animals》论文发表", "date_start": "2023-10-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕活性算力与合成智能治理讨论人脑类器官移植动物的伦理。", "summary": "该节点将人脑类器官移植伦理纳入合成智能治理路径。", "sources": [ "SRC-873" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经形态计算、活性算力与合成智能", "notes": "第 156 轮补录：活性算力与合成智能治理；待本地复核。；日期补齐：Crossref 2023-10-04 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-271", "title": "《Consciousness and the Ethics of Human Brain Organoid Research》论文发表", "date_start": "2023-03-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕活性算力与合成智能治理讨论意识与人脑类器官研究伦理。", "summary": "该节点将意识伦理纳入活性算力治理路径。", "sources": [ "SRC-874" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经形态计算、活性算力与合成智能", "notes": "第 156 轮补录：活性算力与合成智能治理；待本地复核。；日期补齐：Crossref 2023-03-23 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-272", "title": "《Human Brain Organoid Transplantation: Testing the Foundations of Animal Research Ethics》论文发表", "date_start": "2024-04-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕活性算力与合成智能治理讨论人脑类器官移植对动物研究伦理基础的影响。", "summary": "该节点将人脑类器官移植伦理纳入合成智能治理路径。", "sources": [ "SRC-875" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经形态计算、活性算力与合成智能", "notes": "第 156 轮补录：活性算力与合成智能治理；待本地复核。；日期补齐：Crossref 2024-04-17 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-295", "title": "《Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial》论文发表", "date_start": "2021-04-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕器官灌注与移植结局报告低温机器灌注肝脏移植随机试验结果。", "summary": "该节点将低温机器灌注随机证据纳入器官保存路径。", "sources": [ "SRC-876" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官保存、机器灌注与异种移植", "notes": "第 157 轮补录：器官灌注与移植结局；待本地复核。；日期补齐：Crossref 2021-04-15 (published-print, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-296", "title": "《Normothermic Machine Perfusion Increases Donor Liver Use》论文发表", "date_start": "2022-08-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕器官灌注与移植结局报告常温机器灌注增加供肝使用。", "summary": "该节点将常温机器灌注临床证据纳入器官保存路径。", "sources": [ "SRC-877" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官保存、机器灌注与异种移植", "notes": "第 157 轮补录：器官灌注与移植结局；待本地复核。；日期补齐：Crossref 2022-08-01 (published-print, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-297", "title": "《Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation: A randomized, open-label, clinical trial》论文发表", "date_start": "2023-12-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕器官灌注与移植结局报告便携低温携氧机器灌注随机试验。", "summary": "该节点将便携低温携氧灌注纳入器官保存路径。", "sources": [ "SRC-878" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官保存、机器灌注与异种移植", "notes": "第 157 轮补录：器官灌注与移植结局；待本地复核。；日期补齐：Crossref 2023-12-13 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-298", "title": "《Normothermic Machine Perfusion: Transforming \"Unacceptable\" Liver Transplants into Reality》论文发表", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕器官灌注与移植结局报告常温机器灌注转化不可接受供肝。", "summary": "该节点将常温灌注转化证据纳入器官可及性路径。", "sources": [ "SRC-879" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官保存、机器灌注与异种移植", "notes": "第 157 轮补录：器官灌注与移植结局；待本地复核。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-299", "title": "《Automated Hypothermic Machine Perfusion for Donor Kidney Preservation》论文发表", "date_start": "2025-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该研究围绕器官灌注与移植结局报告自动化低温机器灌注保存供肾。", "summary": "该节点将自动化低温灌注纳入器官保存路径。", "sources": [ "SRC-880" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官保存、机器灌注与异种移植", "notes": "第 157 轮补录：器官灌注与移植结局；待本地复核。；日期补齐：Crossref 2025-08 (published-print, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-273", "title": "《Structural Ageism and the Health of Older Adults》论文发表", "date_start": "2020-10-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕老年权利与健康老龄化政策讨论结构性年龄歧视与老年人健康。", "summary": "该节点将结构性年龄歧视纳入老年权利治理路径。", "sources": [ "SRC-881" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "老年权利、健康老龄化与公共政策", "notes": "第 158 轮补录：老年权利与健康老龄化政策；待本地复核。；日期补齐：Crossref 2020-10-16 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-274", "title": "《Experiences of Everyday Ageism and the Health of Older US Adults》论文发表", "date_start": "2022-06-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕老年权利与健康老龄化政策报告日常年龄歧视与老年人健康关联。", "summary": "该节点将日常年龄歧视证据纳入老年权利治理路径。", "sources": [ "SRC-882" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "老年权利、健康老龄化与公共政策", "notes": "第 158 轮补录：老年权利与健康老龄化政策；待本地复核。；日期补齐：Crossref 2022-06-15 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-275", "title": "《The Capability Approach and the WHO healthy ageing framework (for the UN Decade of Healthy Ageing)》论文发表", "date_start": "2023-10-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕老年权利与健康老龄化政策讨论能力方法与 WHO 健康老龄化框架。", "summary": "该节点将能力方法纳入健康老龄化治理路径。", "sources": [ "SRC-883" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "老年权利、健康老龄化与公共政策", "notes": "第 158 轮补录：老年权利与健康老龄化政策；待本地复核。；日期补齐：Crossref 2023-10-30 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-276", "title": "《The Decade of Healthy Ageing: progress and challenges ahead》论文发表", "date_start": "2024-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕老年权利与健康老龄化政策评估健康老龄化十年进展与挑战。", "summary": "该节点将健康老龄化十年评估纳入老年权利治理路径。", "sources": [ "SRC-884" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "老年权利、健康老龄化与公共政策", "notes": "第 158 轮补录：老年权利与健康老龄化政策；待本地复核。；日期补齐：Crossref 2024-01 (published-print, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-277", "title": "《Decade of healthy ageing in Asia》论文发表", "date_start": "2023-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕老年权利与健康老龄化政策讨论亚洲健康老龄化十年实践。", "summary": "该节点将亚洲健康老龄化实践纳入老年权利治理路径。", "sources": [ "SRC-885" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "老年权利、健康老龄化与公共政策", "notes": "第 158 轮补录：老年权利与健康老龄化政策；待本地复核。；日期补齐：Crossref 2023-06 (published-print, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-278", "title": "《Is taurine an aging biomarker?》论文发表", "date_start": "2025-06-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕生物年龄指标监管接受度讨论生物年龄指标进入监管或临床终点的问题。", "summary": "该节点将生物年龄指标监管接受度的最新讨论纳入衰老测量监管路径。", "sources": [ "SRC-886" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "第 159 轮补录：生物年龄指标监管接受度；待本地复核。；日期补齐：Crossref 2025-06-05 (published-print, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-279", "title": "《Regulatory Roles of Exosomes in Aging and Aging-Related Diseases》论文发表", "date_start": "2025-02-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕生物年龄指标监管接受度讨论生物年龄指标进入监管或临床终点的问题。", "summary": "该节点将生物年龄指标监管接受度的最新讨论纳入衰老测量监管路径。", "sources": [ "SRC-887" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "第 159 轮补录：生物年龄指标监管接受度；待本地复核。；日期补齐：Crossref 2025-02-18 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-280", "title": "《NfL makes regulatory debut as neurodegenerative disease biomarker》论文发表", "date_start": "2023-05-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕生物年龄指标监管接受度讨论生物年龄指标进入监管或临床终点的问题。", "summary": "该节点将生物年龄指标监管接受度的最新讨论纳入衰老测量监管路径。", "sources": [ "SRC-888" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "第 159 轮补录：生物年龄指标监管接受度；待本地复核。；日期补齐：Crossref 2023-05-17 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-281", "title": "《The Aging Biomarker Consortium represents a new era for aging research in China》论文发表", "date_start": "2023-07-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕生物年龄指标监管接受度讨论生物年龄指标进入监管或临床终点的问题。", "summary": "该节点将生物年龄指标监管接受度的最新讨论纳入衰老测量监管路径。", "sources": [ "SRC-889" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "第 159 轮补录：生物年龄指标监管接受度；待本地复核。；日期补齐：Crossref 2023-07-19 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-282", "title": "《The clinical trial landscape of osteosarcoma: integrating trial data, immunotherapeutic trends, and biomarker insights》论文发表", "date_start": "2026-03-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕生物年龄指标监管接受度讨论生物年龄指标进入监管或临床终点的问题。", "summary": "该节点将生物年龄指标监管接受度的最新讨论纳入衰老测量监管路径。", "sources": [ "SRC-890" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康寿命、衰老测量与长寿医学监管", "notes": "第 159 轮补录：生物年龄指标监管接受度；待本地复核。；日期补齐：Crossref 2026-03-10 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-300", "title": "《AI-enabled drug discovery reaches clinical milestone》论文发表", "date_start": "2025-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕AI 药物管线与临床失败教训报告 AI 药物管线、候选分子或临床试验结果。", "summary": "该节点将AI 药物管线与临床失败教训的最新证据纳入 AI 药物发现路径。", "sources": [ "SRC-891" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 药物发现、管线统计与临床转化", "notes": "第 160 轮补录：AI 药物管线与临床失败教训；待本地复核。；日期补齐：Crossref 2025-07-01 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-301", "title": "《Machine learning in drug delivery》论文发表", "date_start": "2024-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕AI 药物管线与临床失败教训报告 AI 药物管线、候选分子或临床试验结果。", "summary": "该节点将AI 药物管线与临床失败教训的最新证据纳入 AI 药物发现路径。", "sources": [ "SRC-892" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 药物发现、管线统计与临床转化", "notes": "第 160 轮补录：AI 药物管线与临床失败教训；待本地复核。；日期补齐：Crossref 2024-09 (published-print, month, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-302", "title": "《Machine learning in drug discovery》论文发表", "date_start": "2023-07-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕AI 药物管线与临床失败教训报告 AI 药物管线、候选分子或临床试验结果。", "summary": "该节点将AI 药物管线与临床失败教训的最新证据纳入 AI 药物发现路径。", "sources": [ "SRC-893" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 药物发现、管线统计与临床转化", "notes": "第 160 轮补录：AI 药物管线与临床失败教训；待本地复核。；日期补齐：Crossref 2023-07-14 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-303", "title": "《Artificial intelligence in drug development》论文发表", "date_start": "2025-01-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕 AI 药物管线与临床失败教训讨论人工智能在药物开发中的应用。", "summary": "该节点将 AI 药物开发综述纳入药物管线路径。", "sources": [ "SRC-894" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 药物发现、管线统计与临床转化", "notes": "第 160 轮补录：AI 药物管线与临床失败教训；待本地复核。；日期补齐：Crossref 2025-01-20 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-304", "title": "《DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets》论文发表", "date_start": "2022-11-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕 AI 药物管线与临床失败教训报告候选药物靶点可药性预测框架。", "summary": "该节点将可药性预测模型纳入 AI 药物管线路径。", "sources": [ "SRC-895" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI 药物发现、管线统计与临床转化", "notes": "第 160 轮补录：AI 药物管线与临床失败教训；待本地复核。；日期补齐：Crossref 2022-11-24 (published-online, day, v3)", "created_at": "2026-08-06T16:56:56Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-305", "title": "《Partial cellular reprogramming: A deep dive into an emerging rejuvenation technology》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕细胞重编程与临床转化报告重编程或年轻化策略的机制或转化证据。", "summary": "该节点将细胞重编程与临床转化的最新证据纳入细胞重编程路径。", "sources": [ "SRC-896" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程、表观遗传年轻化与再生医学", "notes": "第 161 轮补录：细胞重编程与临床转化；待本地复核。；日期补齐：Crossref 2023-12 (published-online, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-306", "title": "《Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective》论文发表", "date_start": "2024-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕细胞重编程与临床转化报告重编程或年轻化策略的机制或转化证据。", "summary": "该节点将细胞重编程与临床转化的最新证据纳入细胞重编程路径。", "sources": [ "SRC-897" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程、表观遗传年轻化与再生医学", "notes": "第 161 轮补录：细胞重编程与临床转化；待本地复核。；日期补齐：Crossref 2024-03 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-307", "title": "《Conserved biological processes in partial cellular reprogramming: Relevance to aging and rejuvenation》论文发表", "date_start": "2025-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕细胞重编程与临床转化报告重编程或年轻化策略的机制或转化证据。", "summary": "该节点将细胞重编程与临床转化的最新证据纳入细胞重编程路径。", "sources": [ "SRC-898" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程、表观遗传年轻化与再生医学", "notes": "第 161 轮补录：细胞重编程与临床转化；待本地复核。；日期补齐：Crossref 2025-06 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-308", "title": "《Cellular reprogramming beyond pluripotency》论文发表", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕细胞重编程与临床转化报告重编程或年轻化策略的机制或转化证据。", "summary": "该节点将细胞重编程与临床转化的最新证据纳入细胞重编程路径。", "sources": [ "SRC-899" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程、表观遗传年轻化与再生医学", "notes": "第 161 轮补录：细胞重编程与临床转化；待本地复核。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-309", "title": "《Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming》论文发表", "date_start": "2023-12-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕细胞重编程与临床转化报告重编程或年轻化策略的机制或转化证据。", "summary": "该节点将细胞重编程与临床转化的最新证据纳入细胞重编程路径。", "sources": [ "SRC-900" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞重编程、表观遗传年轻化与再生医学", "notes": "第 161 轮补录：细胞重编程与临床转化；待本地复核。；日期补齐：Crossref 2023-12-15 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-310", "title": "《Clinical Outcomes of Left Ventricular Assist Device Pump Infection》论文发表", "date_start": "2023-08-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕人工器官与生命维持报告左心室辅助装置泵感染的临床结局。", "summary": "该节点将泵感染结局纳入人工器官维护路径。", "sources": [ "SRC-901" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "人工器官、生命维持与死亡边界", "notes": "第 162 轮补录：人工器官与生命维持；待本地复核。；日期补齐：Crossref 2023-08-07 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-311", "title": "《Impact of Frailty on Left Ventricular Assist Device Clinical Outcomes》论文发表", "date_start": "2023-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕人工器官与生命维持报告衰弱对心室辅助装置结局的影响。", "summary": "该节点将衰弱评估纳入人工器官决策路径。", "sources": [ "SRC-902" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "人工器官、生命维持与死亡边界", "notes": "第 162 轮补录：人工器官与生命维持；待本地复核。；日期补齐：Crossref 2023-11 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-312", "title": "《Mechanical circulatory support in patients with congenital heart disease: a European Registry for Patients with Mechanical Circulatory Support》论文发表", "date_start": "2024-05-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕人工器官与生命维持报告先天性心脏病患者机械循环支持欧洲登记数据。", "summary": "该节点将机械循环支持登记纳入人工器官路径。", "sources": [ "SRC-903" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "人工器官、生命维持与死亡边界", "notes": "第 162 轮补录：人工器官与生命维持；待本地复核。；日期补齐：Crossref 2024-05-23 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-313", "title": "《Clinical outcomes of modified left ventricular assist device driveline management》论文发表", "date_start": "2024-12-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕人工器官与生命维持报告改良驱动线管理的临床结局。", "summary": "该节点将驱动线管理纳入人工器官维护路径。", "sources": [ "SRC-904" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "人工器官、生命维持与死亡边界", "notes": "第 162 轮补录：人工器官与生命维持；待本地复核。；日期补齐：Crossref 2024-12-18 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-314", "title": "《Sex-based differences in left ventricular assist device clinical outcomes》论文发表", "date_start": "2023-10-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕人工器官与生命维持报告心室辅助装置结局的性别差异。", "summary": "该节点将性别差异纳入人工器官结局评估路径。", "sources": [ "SRC-905" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "人工器官、生命维持与死亡边界", "notes": "第 162 轮补录：人工器官与生命维持；待本地复核。；日期补齐：Crossref 2023-10-23 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-283", "title": "《Pace of aging matters for healthspan and lifespan in older adults》论文发表", "date_start": "2025-05-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕健康老龄化治理与失能压缩讨论健康老龄化、失能压缩或公共治理。", "summary": "该节点将健康老龄化治理与失能压缩的最新讨论纳入健康老龄化治理路径。", "sources": [ "SRC-906" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康老龄化、失能压缩与治理", "notes": "第 163 轮补录：健康老龄化治理与失能压缩；待本地复核。；日期补齐：Crossref 2025-05-30 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-285", "title": "《Power to prolong independence and healthy ageing in older adults》论文发表", "date_start": "2024-01-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕健康老龄化治理与失能压缩讨论力量训练维持老年人独立。", "summary": "该节点将力量训练证据纳入失能压缩路径。", "sources": [ "SRC-908" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康老龄化、失能压缩与治理", "notes": "第 163 轮补录：健康老龄化治理与失能压缩；待本地复核。；日期补齐：Crossref 2024-01-04 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-286", "title": "《Healthy ageing in older adults with cardiovascular disease》论文发表", "date_start": "2025-04-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕健康老龄化治理与失能压缩讨论心血管病老年人的健康老龄化。", "summary": "该节点将心血管健康老龄化纳入治理路径。", "sources": [ "SRC-909" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康老龄化、失能压缩与治理", "notes": "第 163 轮补录：健康老龄化治理与失能压缩；待本地复核。；日期补齐：Crossref 2025-04-29 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-287", "title": "《Improving oral health of older adults for healthy ageing》论文发表", "date_start": "2024-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕健康老龄化治理与失能压缩讨论改善老年人口腔健康。", "summary": "该节点将口腔健康纳入健康老龄化治理路径。", "sources": [ "SRC-910" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康老龄化、失能压缩与治理", "notes": "第 163 轮补录：健康老龄化治理与失能压缩；待本地复核。；日期补齐：Crossref 2024-01 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-288", "title": "《Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine》论文发表", "date_start": "2024-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿医学临床实践讨论长寿医学进入临床实践的方法与证据。", "summary": "该节点将长寿医学临床实践的最新讨论纳入长寿医学制度路径。", "sources": [ "SRC-911" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿医学、老年医学与临床实践", "notes": "第 164 轮补录：长寿医学临床实践；待本地复核。；日期补齐：Crossref 2024-09 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-289", "title": "《Beyond the linear genome: how reference bias threatens preventive medicine and geroscience》论文发表", "date_start": "2026-07-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿医学临床实践讨论长寿医学进入临床实践的方法与证据。", "summary": "该节点将长寿医学临床实践的最新讨论纳入长寿医学制度路径。", "sources": [ "SRC-912" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿医学、老年医学与临床实践", "notes": "第 164 轮补录：长寿医学临床实践；待本地复核。；日期补齐：Crossref 2026-07-25 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-290", "title": "《Healthspan as a Clinical Outcome: Reframing Longevity in Modern Medicine》论文发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿医学临床实践提出以健康寿命作为临床结局。", "summary": "该节点将健康寿命结局纳入长寿医学临床路径。", "sources": [ "SRC-913" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿医学、老年医学与临床实践", "notes": "第 164 轮补录：长寿医学临床实践；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-291", "title": "《Science of longevity medicine》论文发表", "date_start": "2025-12-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿医学临床实践讨论长寿医学的科学基础。", "summary": "该节点将长寿医学科学基础纳入临床制度路径。", "sources": [ "SRC-914" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿医学、老年医学与临床实践", "notes": "第 164 轮补录：长寿医学临床实践；待本地复核。；日期补齐：Crossref 2025-12-12 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-292", "title": "《Toward responsible longevity medicine: Swiss framework for healthy longevity medicine clinics》论文发表", "date_start": "2026-01-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿医学临床实践提出瑞士健康长寿诊所责任框架。", "summary": "该节点将责任性长寿医学框架纳入临床制度路径。", "sources": [ "SRC-915" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿医学、老年医学与临床实践", "notes": "第 164 轮补录：长寿医学临床实践；待本地复核。；日期补齐：Crossref 2026-01-21 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-315", "title": "《Agonal cell resuscitation strategy to promote tissue repair》论文发表", "date_start": "2026-04-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕再生医学转化与细胞疗法报告再生医学或细胞疗法的临床转化证据。", "summary": "该节点将再生医学转化与细胞疗法的最新证据纳入再生医学路径。", "sources": [ "SRC-916" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞与基因疗法、再生医学与临床转化", "notes": "第 165 轮补录：再生医学转化与细胞疗法；待本地复核。；日期补齐：Crossref 2026-04-11 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-316", "title": "《Stem cell-derived exosome versus stem cell therapy》论文发表", "date_start": "2023-04-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕再生医学转化与细胞疗法比较干细胞来源外泌体与干细胞治疗。", "summary": "该节点将外泌体疗法比较纳入再生医学转化路径。", "sources": [ "SRC-917" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞与基因疗法、再生医学与临床转化", "notes": "第 165 轮补录：再生医学转化与细胞疗法；待本地复核。；日期补齐：Crossref 2023-04-12 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-317", "title": "《Challenges in the Clinical Translation of Exosomal Therapy in Regenerative Medicine》论文发表", "date_start": "2022-02-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕再生医学转化与细胞疗法讨论外泌体疗法的临床转化挑战。", "summary": "该节点将外泌体临床转化挑战纳入再生医学路径。", "sources": [ "SRC-918" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞与基因疗法、再生医学与临床转化", "notes": "第 165 轮补录：再生医学转化与细胞疗法；待本地复核。；日期补齐：Crossref 2022-02-21 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-318", "title": "《Clinical Trial Landscape of Stem Cell Therapy for Peripheral Arterial Disease》论文发表", "date_start": "2025-11-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕再生医学转化与细胞疗法分析外周动脉疾病干细胞治疗临床试验格局。", "summary": "该节点将干细胞临床试验格局纳入再生医学转化路径。", "sources": [ "SRC-919" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞与基因疗法、再生医学与临床转化", "notes": "第 165 轮补录：再生医学转化与细胞疗法；待本地复核。；日期补齐：Crossref 2025-11-26 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-319", "title": "《Biodegradable polyurethane scaffolds in regenerative medicine: Clinical translation review》论文发表", "date_start": "2022-04-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕再生医学转化与细胞疗法综述生物可降解聚氨酯支架的临床转化。", "summary": "该节点将可降解支架临床转化纳入再生医学路径。", "sources": [ "SRC-920" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞与基因疗法、再生医学与临床转化", "notes": "第 165 轮补录：再生医学转化与细胞疗法；待本地复核。；日期补齐：Crossref 2022-04-28 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-293", "title": "《Ready or not, the digital afterlife is here》论文发表", "date_start": "2025-09-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕数字遗产与数字永生讨论数字遗产、在线身份或数字永生问题。", "summary": "该节点将数字遗产与数字永生的最新讨论纳入数字迁移路径。", "sources": [ "SRC-921" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字迁移、身份连续与数字遗产", "notes": "第 166 轮补录：数字遗产与数字永生；待本地复核。；日期补齐：Crossref 2025-09-15 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-294", "title": "《The law of digital afterlife: the Chinese experience of AI \"resurrection\" and \"grief tech\"》论文发表", "date_start": "2025-01-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕数字遗产与数字永生讨论 AI 复活与哀悼技术的法律问题。", "summary": "该节点将数字来世法律纳入数字遗产路径。", "sources": [ "SRC-922" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字迁移、身份连续与数字遗产", "notes": "第 166 轮补录：数字遗产与数字永生；待本地复核。；日期补齐：Crossref 2025-01-08 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-295", "title": "《Digital Access, Digital Literacy, and Afterlife Preparedness: Societal Contexts of Digital Afterlife Traces》论文发表", "date_start": "2024-08-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该研究围绕数字遗产与数字永生报告数字接入、素养与来世准备的社会背景。", "summary": "该节点将数字来世准备纳入数字遗产路径。", "sources": [ "SRC-923" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字迁移、身份连续与数字遗产", "notes": "第 166 轮补录：数字遗产与数字永生；待本地复核。；日期补齐：Crossref 2024-08-27 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-296", "title": "《Digital afterlife leaders: professionalisation as a social innovation in the digital afterlife industry》论文发表", "date_start": "2025-01-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕数字遗产与数字永生讨论数字来世行业的专业化。", "summary": "该节点将数字来世行业纳入数字遗产治理路径。", "sources": [ "SRC-924" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字迁移、身份连续与数字遗产", "notes": "第 166 轮补录：数字遗产与数字永生；待本地复核。；日期补齐：Crossref 2025-01-26 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-297", "title": "《Personal digital legacy preservation by libraries》论文发表", "date_start": "2020-08-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕数字遗产与数字永生讨论图书馆保存个人数字遗产。", "summary": "该节点将个人数字遗产保存纳入数字遗产路径。", "sources": [ "SRC-925" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字迁移、身份连续与数字遗产", "notes": "第 166 轮补录：数字遗产与数字永生；待本地复核。；日期补齐：Crossref 2020-08-17 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-298", "title": "《Applying the IEEE BRAIN neuroethics framework to intra-cortical brain-computer interfaces》论文发表", "date_start": "2024-04-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕神经技术与脑数据权利讨论脑数据权利、神经技术伦理或治理。", "summary": "该节点将神经技术与脑数据权利的最新讨论纳入神经权利治理路径。", "sources": [ "SRC-926" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 167 轮补录：神经技术与脑数据权利；待本地复核。；日期补齐：Crossref 2024-04-04 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-299", "title": "《Privacy Challenges to the Democratization of Brain Data》论文发表", "date_start": "2020-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕神经技术与脑数据权利讨论脑数据民主化带来的隐私挑战。", "summary": "该节点将脑数据隐私挑战纳入神经权利治理路径。", "sources": [ "SRC-927" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 167 轮补录：神经技术与脑数据权利；待本地复核。；日期补齐：Crossref 2020-06 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-300", "title": "《Brain Data in Context: Are New Rights the Way to Mental and Brain Privacy?》论文发表", "date_start": "2023-04-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕神经技术与脑数据权利讨论新权利是否保障脑隐私。", "summary": "该节点将脑数据权利争论纳入神经权利治理路径。", "sources": [ "SRC-928" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 167 轮补录：神经技术与脑数据权利；待本地复核。；日期补齐：Crossref 2023-04-05 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-301", "title": "《Neurorights in the Constitution: from neurotechnology to ethics and politics》论文发表", "date_start": "2024-10-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕神经技术与脑数据权利讨论宪法中的神经权利。", "summary": "该节点将宪法神经权利纳入神经权利治理路径。", "sources": [ "SRC-929" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 167 轮补录：神经技术与脑数据权利；待本地复核。；日期补齐：Crossref 2024-10-21 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-302", "title": "《Neurorights in neurology》论文发表", "date_start": "2025-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕神经技术与脑数据权利讨论神经病学中的神经权利。", "summary": "该节点将神经病学神经权利纳入神经权利治理路径。", "sources": [ "SRC-930" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 167 轮补录：神经技术与脑数据权利；待本地复核。；日期补齐：Crossref 2025-05 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-320", "title": "《Effective engagement in computerized cognitive training for older adults》论文发表", "date_start": "2025-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕认知训练与注意力增强报告认知训练或注意力增强的干预证据。", "summary": "该节点将认知训练与注意力增强的最新证据纳入认知增强路径。", "sources": [ "SRC-931" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 168 轮补录：认知训练与注意力增强；待本地复核。；日期补齐：Crossref 2025-02 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-321", "title": "《Mindfulness Training and Exercise and Cognitive Function in Older Adults》论文发表", "date_start": "2023-04-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕认知训练与注意力增强报告认知训练或注意力增强的干预证据。", "summary": "该节点将认知训练与注意力增强的最新证据纳入认知增强路径。", "sources": [ "SRC-932" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 168 轮补录：认知训练与注意力增强；待本地复核。；日期补齐：Crossref 2023-04-04 (published-print, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-322", "title": "《Mindfulness Training and Exercise and Cognitive Function in Older Adults—Reply》论文发表", "date_start": "2023-04-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕认知训练与注意力增强报告认知训练或注意力增强的干预证据。", "summary": "该节点将认知训练与注意力增强的最新证据纳入认知增强路径。", "sources": [ "SRC-933" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 168 轮补录：认知训练与注意力增强；待本地复核。；日期补齐：Crossref 2023-04-04 (published-print, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-323", "title": "《Digital cognitive training for functionality in mild cognitive impairment: a randomized controlled clinical trial》论文发表", "date_start": "2025-01-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕认知训练与注意力增强报告认知训练或注意力增强的干预证据。", "summary": "该节点将认知训练与注意力增强的最新证据纳入认知增强路径。", "sources": [ "SRC-934" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 168 轮补录：认知训练与注意力增强；待本地复核。；日期补齐：Crossref 2025-01-06 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-324", "title": "《Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial》论文发表", "date_start": "2023-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕认知训练与注意力增强报告认知训练或注意力增强的干预证据。", "summary": "该节点将认知训练与注意力增强的最新证据纳入认知增强路径。", "sources": [ "SRC-935" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、记忆编辑与神经权利", "notes": "第 168 轮补录：认知训练与注意力增强；待本地复核。；日期补齐：Crossref 2023-05 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-325", "title": "《Sleep health in the older adults: Architecture, circadian changes, and common sleep disorders》论文发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕睡眠与昼夜节律报告睡眠或昼夜节律对健康寿命的影响。", "summary": "该节点将睡眠与昼夜节律的最新证据纳入主体维护路径。", "sources": [ "SRC-936" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠、昼夜节律与健康寿命", "notes": "第 169 轮补录：睡眠与昼夜节律；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-326", "title": "《A familial natural short sleep mutation in dec2 extends healthspan and lifespan in Drosophila》论文发表", "date_start": "2025-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕睡眠与昼夜节律报告睡眠或昼夜节律对健康寿命的影响。", "summary": "该节点将睡眠与昼夜节律的最新证据纳入主体维护路径。", "sources": [ "SRC-937" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠、昼夜节律与健康寿命", "notes": "第 169 轮补录：睡眠与昼夜节律；待本地复核。；日期补齐：Crossref 2025-09 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-327", "title": "《Global Healthspan Summit 2023: closing the gap between healthspan and lifespan》论文发表", "date_start": "2024-03-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕睡眠与昼夜节律报告睡眠或昼夜节律对健康寿命的影响。", "summary": "该节点将睡眠与昼夜节律的最新证据纳入主体维护路径。", "sources": [ "SRC-938" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠、昼夜节律与健康寿命", "notes": "第 169 轮补录：睡眠与昼夜节律；待本地复核。；日期补齐：Crossref 2024-03-14 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-328", "title": "《Sleep health and aging: Recommendations for promoting healthy sleep among older adults: A National Sleep Foundation report》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与昼夜节律提出促进老年人健康睡眠的建议。", "summary": "该节点将老年人睡眠建议纳入睡眠维护路径。", "sources": [ "SRC-939" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠、昼夜节律与健康寿命", "notes": "第 169 轮补录：睡眠与昼夜节律；待本地复核。；日期补齐：Crossref 2023-12 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-329", "title": "《The circadian rhythm: A key variable in aging?》论文发表", "date_start": "2024-07-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与昼夜节律讨论昼夜节律作为衰老关键变量。", "summary": "该节点将昼夜节律衰老证据纳入睡眠维护路径。", "sources": [ "SRC-940" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠、昼夜节律与健康寿命", "notes": "第 169 轮补录：睡眠与昼夜节律；待本地复核。；日期补齐：Crossref 2024-07-30 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-330", "title": "《Epigenetic Aging and Racialized, Economic, and Environmental Injustice》论文发表", "date_start": "2024-07-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕环境暴露与表观衰老报告环境暴露与表观衰老之间的关联证据。", "summary": "该节点将环境暴露与表观衰老的最新证据纳入环境维护路径。", "sources": [ "SRC-941" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "环境暴露、表观遗传与健康寿命", "notes": "第 170 轮补录：环境暴露与表观衰老；待本地复核。；日期补齐：Crossref 2024-07-29 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-331", "title": "《Associations between environmental air pollution, greenspace and apparent biological aging: a cross-sectional study》论文发表", "date_start": "2025-03-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕环境暴露与表观衰老报告环境暴露与表观衰老之间的关联证据。", "summary": "该节点将环境暴露与表观衰老的最新证据纳入环境维护路径。", "sources": [ "SRC-942" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "环境暴露、表观遗传与健康寿命", "notes": "第 170 轮补录：环境暴露与表观衰老；待本地复核。；日期补齐：Crossref 2025-03-11 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-332", "title": "《Impact of air pollution on cardiovascular aging》论文发表", "date_start": "2023-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕环境暴露与表观衰老报告环境暴露与表观衰老之间的关联证据。", "summary": "该节点将环境暴露与表观衰老的最新证据纳入环境维护路径。", "sources": [ "SRC-943" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "环境暴露、表观遗传与健康寿命", "notes": "第 170 轮补录：环境暴露与表观衰老；待本地复核。；日期补齐：Crossref 2023-09 (published-print, month, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-333", "title": "《Air pollution and impulsive choice in aging: evidence from delay discounting》论文发表", "date_start": "2025-09-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕环境暴露与表观衰老报告环境暴露与表观衰老之间的关联证据。", "summary": "该节点将环境暴露与表观衰老的最新证据纳入环境维护路径。", "sources": [ "SRC-944" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "环境暴露、表观遗传与健康寿命", "notes": "第 170 轮补录：环境暴露与表观衰老；待本地复核。；日期补齐：Crossref 2025-09-24 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-334", "title": "《Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures》论文发表", "date_start": "2023-09-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕环境暴露与表观衰老报告环境暴露与表观衰老之间的关联证据。", "summary": "该节点将环境暴露与表观衰老的最新证据纳入环境维护路径。", "sources": [ "SRC-945" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "环境暴露、表观遗传与健康寿命", "notes": "第 170 轮补录：环境暴露与表观衰老；待本地复核。；日期补齐：Crossref 2023-09-09 (published-online, day, v3)", "created_at": "2026-08-06T16:56:57Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-335", "title": "《Perspectives on biomarkers of reproductive aging for fertility and beyond》论文发表", "date_start": "2024-12-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生殖医学与生育力维护报告或讨论可复核的学术证据。", "summary": "该节点将生殖医学与生育力维护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-946" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖保存、生育力与未来选择权", "notes": "第 171 轮补录：生殖医学与生育力维护；待本地复核。；日期补齐：Crossref 2024-12-13 (published-online, day, v3)", "created_at": "2026-08-06T17:01:58Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-336", "title": "《Obesity, Fertility, and Reproductive Health Across the Life Course》论文发表", "date_start": "2026-08-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生殖医学与生育力维护报告或讨论可复核的学术证据。", "summary": "该节点将生殖医学与生育力维护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-947" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖保存、生育力与未来选择权", "notes": "第 171 轮补录：生殖医学与生育力维护；待本地复核。；日期补齐：Crossref 2026-08-04 (published-online, day, v3)", "created_at": "2026-08-06T17:01:58Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-337", "title": "《Seminal fluid cytokines in reproductive health and fertility of men》论文发表", "date_start": "2026-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生殖医学与生育力维护报告或讨论可复核的学术证据。", "summary": "该节点将生殖医学与生育力维护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-948" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖保存、生育力与未来选择权", "notes": "第 171 轮补录：生殖医学与生育力维护；待本地复核。；日期补齐：Crossref 2026-05 (published-print, month, v3)", "created_at": "2026-08-06T17:01:58Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-338", "title": "《Fertility preservation and mental health among cancer patients of reproductive age》论文发表", "date_start": "2025-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生殖医学与生育力维护报告或讨论可复核的学术证据。", "summary": "该节点将生殖医学与生育力维护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-949" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖保存、生育力与未来选择权", "notes": "第 171 轮补录：生殖医学与生育力维护；待本地复核。；日期补齐：Crossref 2025-10 (published-print, month, v3)", "created_at": "2026-08-06T17:01:58Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-339", "title": "《Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging》论文发表", "date_start": "2023-10-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生殖医学与生育力维护报告或讨论可复核的学术证据。", "summary": "该节点将生殖医学与生育力维护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-950" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖保存、生育力与未来选择权", "notes": "第 171 轮补录：生殖医学与生育力维护；待本地复核。；日期补齐：Crossref 2023-10-16 (published-online, day, v3)", "created_at": "2026-08-06T17:01:58Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-340", "title": "《Aging Gut Microbiome in Healthy and Unhealthy Aging》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕微生物组与免疫代谢报告或讨论可复核的学术证据。", "summary": "该节点将微生物组与免疫代谢的最新证据纳入有效永生研究年表。", "sources": [ "SRC-951" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "微生物组、免疫与代谢维护", "notes": "第 172 轮补录：微生物组与免疫代谢；待本地复核。；日期补齐：Crossref 2024 (published-online, year, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-341", "title": "《Polystyrene nanoplastics promotes inflammation and aging in young mice through the oral-gut microbiome axis》论文发表", "date_start": "2026-05-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕微生物组与免疫代谢报告或讨论可复核的学术证据。", "summary": "该节点将微生物组与免疫代谢的最新证据纳入有效永生研究年表。", "sources": [ "SRC-952" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "微生物组、免疫与代谢维护", "notes": "第 172 轮补录：微生物组与免疫代谢；待本地复核。；日期补齐：Crossref 2026-05-28 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-342", "title": "《The Gut Microbiome and Aging》论文发表", "date_start": "2020-06-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕微生物组与免疫代谢综述肠道微生物组与衰老的关系。", "summary": "该节点将肠道微生物组纳入免疫代谢维护路径。", "sources": [ "SRC-953" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "微生物组、免疫与代谢维护", "notes": "第 172 轮补录：微生物组与免疫代谢；待本地复核。；日期补齐：Crossref 2020-06-18 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-343", "title": "《Gut Instincts: The Gut Microbiome-Cardiovascular Inflammation Axis》论文发表", "date_start": "2025-04-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕微生物组与免疫代谢讨论肠道微生物与心血管炎症轴。", "summary": "该节点将肠道-心血管炎症轴纳入免疫代谢维护路径。", "sources": [ "SRC-954" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "微生物组、免疫与代谢维护", "notes": "第 172 轮补录：微生物组与免疫代谢；待本地复核。；日期补齐：Crossref 2025-04-11 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-344", "title": "《Effect of Gut Microbiota-Mediated Tryptophan Metabolism on Inflammaging in Frailty and Sarcopenia》论文发表", "date_start": "2024-02-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕微生物组与免疫代谢报告肠道菌群色氨酸代谢对衰弱和肌少症炎症衰老的影响。", "summary": "该节点将菌群-色氨酸-炎症衰老链路纳入免疫代谢维护路径。", "sources": [ "SRC-955" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "微生物组、免疫与代谢维护", "notes": "第 172 轮补录：微生物组与免疫代谢；待本地复核。；日期补齐：Crossref 2024-02-15 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-345", "title": "《Semaglutide Improves Heart Failure and Cardiovascular Disease》论文发表", "date_start": "2023-09-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与循环韧性报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与循环韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-956" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管衰老与循环系统韧性", "notes": "第 173 轮补录：心血管衰老与循环韧性；待本地复核。；日期补齐：Crossref 2023-09-26 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-346", "title": "《Intravenous iron therapy reduces cardiovascular events in heart failure》论文发表", "date_start": "2025-08-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与循环韧性报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与循环韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-957" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管衰老与循环系统韧性", "notes": "第 173 轮补录：心血管衰老与循环韧性；待本地复核。；日期补齐：Crossref 2025-08-01 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-347", "title": "《Arterial stiffness and vascular aging: mechanisms, prevention, and therapy》论文发表", "date_start": "2025-09-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与循环韧性报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与循环韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-958" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管衰老与循环系统韧性", "notes": "第 173 轮补录：心血管衰老与循环韧性；待本地复核。；日期补齐：Crossref 2025-09-01 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-348", "title": "《Cardiovascular Aging and Exercise: Implications for Heart Failure Prevention and Management》论文发表", "date_start": "2025-07-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与循环韧性讨论运动对心血管老化和心衰预防的作用。", "summary": "该节点将运动干预纳入心血管衰老维护路径。", "sources": [ "SRC-959" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管衰老与循环系统韧性", "notes": "第 173 轮补录：心血管衰老与循环韧性；待本地复核。；日期补齐：Crossref 2025-07-07 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-349", "title": "《Cardiovascular Aging》论文发表", "date_start": "2025-07-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与循环韧性综述心血管衰老机制与干预。", "summary": "该节点将心血管衰老综述纳入循环韧性路径。", "sources": [ "SRC-960" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管衰老与循环系统韧性", "notes": "第 173 轮补录：心血管衰老与循环韧性；待本地复核。；日期补齐：Crossref 2025-07-23 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-350", "title": "《Sarcopenia in Older Adults》论文发表", "date_start": "2019-11-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕骨骼肌肉与身体功能综述老年人肌少症。", "summary": "该节点将肌少症综述纳入身体功能维护路径。", "sources": [ "SRC-961" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼肌肉、肌少症与身体功能", "notes": "第 174 轮补录：骨骼肌肉与身体功能；待本地复核。；日期补齐：Crossref 2019-11-02 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-351", "title": "《Blocking myostatin: muscle mass equals muscle strength?》论文发表", "date_start": "2020-12-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕骨骼肌肉与身体功能讨论抑制肌生成抑制素能否等同增强力量。", "summary": "该节点将肌生成抑制素干预纳入骨骼肌肉路径。", "sources": [ "SRC-962" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼肌肉、肌少症与身体功能", "notes": "第 174 轮补录：骨骼肌肉与身体功能；待本地复核。；日期补齐：Crossref 2020-12-19 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-352", "title": "《Muscle mass, muscle strength and the renin-angiotensin system》论文发表", "date_start": "2024-12-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕骨骼肌肉与身体功能讨论肾素-血管紧张素系统与肌肉质量力量。", "summary": "该节点将肌肉-肾素血管紧张素关系纳入骨骼肌肉路径。", "sources": [ "SRC-963" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼肌肉、肌少症与身体功能", "notes": "第 174 轮补录：骨骼肌肉与身体功能；待本地复核。；日期补齐：Crossref 2024-12-24 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-353", "title": "《Physical Frailty: A Biological Marker of Aging?》论文发表", "date_start": "2020-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕骨骼肌肉与身体功能讨论身体衰弱作为衰老生物标志物。", "summary": "该节点将身体衰弱标志物纳入骨骼肌肉与功能路径。", "sources": [ "SRC-964" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼肌肉、肌少症与身体功能", "notes": "第 174 轮补录：骨骼肌肉与身体功能；待本地复核。；日期补齐：Crossref 2020-12 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-354", "title": "《Structured horticultural therapy enhances muscle strength and mass in aging women at risk of sarcopenia》论文发表", "date_start": "2026-03-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕骨骼肌肉与身体功能报告结构化园艺疗法增强肌少症风险女性肌肉。", "summary": "该节点将园艺运动干预纳入骨骼肌肉维护路径。", "sources": [ "SRC-965" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼肌肉、肌少症与身体功能", "notes": "第 174 轮补录：骨骼肌肉与身体功能；待本地复核。；日期补齐：Crossref 2026-03-28 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-355", "title": "《NFATC1 dysfunction-triggered MSC senescence induces tooth aging amenable to senolytic therapy》论文发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕癌症与衰老相关疾病报告或讨论可复核的学术证据。", "summary": "该节点将癌症与衰老相关疾病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-966" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "癌症控制、衰老相关疾病与治疗韧性", "notes": "第 175 轮补录：癌症与衰老相关疾病；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-356", "title": "《Aging, Cellular Senescence, and Glaucoma》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕癌症与衰老相关疾病报告或讨论可复核的学术证据。", "summary": "该节点将癌症与衰老相关疾病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-967" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "癌症控制、衰老相关疾病与治疗韧性", "notes": "第 175 轮补录：癌症与衰老相关疾病；待本地复核。；日期补齐：Crossref 2024 (published-print, year, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-357", "title": "《Exosomal dynamics: Bridging the gap between cellular senescence and cancer therapy》论文发表", "date_start": "2025-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕癌症与衰老相关疾病报告或讨论可复核的学术证据。", "summary": "该节点将癌症与衰老相关疾病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-968" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "癌症控制、衰老相关疾病与治疗韧性", "notes": "第 175 轮补录：癌症与衰老相关疾病；待本地复核。；日期补齐：Crossref 2025-06 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-358", "title": "《Cellular Senescence: Aging, Cancer, and Injury》论文发表", "date_start": "2019-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕癌症与衰老相关疾病综述细胞衰老在衰老、癌症和损伤中的作用。", "summary": "该节点将细胞衰老综述纳入癌症与衰老交叉路径。", "sources": [ "SRC-969" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "癌症控制、衰老相关疾病与治疗韧性", "notes": "第 175 轮补录：癌症与衰老相关疾病；待本地复核。；日期补齐：Crossref 2019-04-01 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-359", "title": "《The aging tumor metabolic microenvironment》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕癌症与衰老相关疾病讨论衰老肿瘤代谢微环境。", "summary": "该节点将衰老肿瘤微环境纳入癌症控制路径。", "sources": [ "SRC-970" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "癌症控制、衰老相关疾病与治疗韧性", "notes": "第 175 轮补录：癌症与衰老相关疾病；待本地复核。；日期补齐：Crossref 2023-12 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-360", "title": "《Alzheimer Disease Pathology and Neurodegeneration in Midlife Obesity: A Pilot Study》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行与阿尔茨海默报告或讨论可复核的学术证据。", "summary": "该节点将神经退行与阿尔茨海默的最新证据纳入有效永生研究年表。", "sources": [ "SRC-971" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行、阿尔茨海默与脑维护", "notes": "第 176 轮补录：神经退行与阿尔茨海默；待本地复核。；日期补齐：Crossref 2024 (published-online, year, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-361", "title": "《Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease》论文发表", "date_start": "2023-12-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行与阿尔茨海默报告或讨论可复核的学术证据。", "summary": "该节点将神经退行与阿尔茨海默的最新证据纳入有效永生研究年表。", "sources": [ "SRC-972" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行、阿尔茨海默与脑维护", "notes": "第 176 轮补录：神经退行与阿尔茨海默；待本地复核。；日期补齐：Crossref 2023-12-19 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-362", "title": "《Resilience and Resistance in Aging and Alzheimer Disease》论文发表", "date_start": "2021-09-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行与阿尔茨海默讨论衰老与阿尔茨海默病中的韧性和抵抗。", "summary": "该节点将脑韧性概念纳入神经退行维护路径。", "sources": [ "SRC-973" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行、阿尔茨海默与脑维护", "notes": "第 176 轮补录：神经退行与阿尔茨海默；待本地复核。；日期补齐：Crossref 2021-09-07 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-363", "title": "《Role of primary aging hallmarks in Alzheimer's disease》论文发表", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行与阿尔茨海默讨论原发性衰老标志在阿尔茨海默病中的作用。", "summary": "该节点将衰老标志与阿尔茨海默链接纳入脑维护路径。", "sources": [ "SRC-974" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行、阿尔茨海默与脑维护", "notes": "第 176 轮补录：神经退行与阿尔茨海默；待本地复核。；日期补齐：Crossref 2023 (published-print, year, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-364", "title": "《Harnessing Brain Pathology for Dementia Prevention》论文发表", "date_start": "2024-03-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行与阿尔茨海默讨论利用脑病理实现痴呆预防。", "summary": "该节点将脑病理预防纳入神经退行路径。", "sources": [ "SRC-975" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行、阿尔茨海默与脑维护", "notes": "第 176 轮补录：神经退行与阿尔茨海默；待本地复核。；日期补齐：Crossref 2024-03-01 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-365", "title": "《Circadian clocks and periodic anticipated fasting prevent fasting-associated hepatic steatosis in calorie restriction》论文发表", "date_start": "2025-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕代谢营养与禁食报告或讨论可复核的学术证据。", "summary": "该节点将代谢营养与禁食的最新证据纳入有效永生研究年表。", "sources": [ "SRC-976" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、代谢健康与饮食干预", "notes": "第 177 轮补录：代谢营养与禁食；待本地复核。；日期补齐：Crossref 2025-08 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-366", "title": "《Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography》论文发表", "date_start": "2023-06-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕代谢营养与禁食报告或讨论可复核的学术证据。", "summary": "该节点将代谢营养与禁食的最新证据纳入有效永生研究年表。", "sources": [ "SRC-977" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、代谢健康与饮食干预", "notes": "第 177 轮补录：代谢营养与禁食；待本地复核。；日期补齐：Crossref 2023-06-02 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-367", "title": "《Brain responses to intermittent fasting and the healthy living diet in older adults》论文发表", "date_start": "2024-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕代谢营养与禁食报告老年人大脑对间歇性禁食和健康饮食的响应。", "summary": "该节点将禁食脑响应纳入代谢营养路径。", "sources": [ "SRC-978" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、代谢健康与饮食干预", "notes": "第 177 轮补录：代谢营养与禁食；待本地复核。；日期补齐：Crossref 2024-08 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-368", "title": "《Dietary and pharmacological energy restriction and exercise for healthspan extension》论文发表", "date_start": "2025-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕代谢营养与禁食讨论饮食、药理能量限制和运动延长健康寿命。", "summary": "该节点将能量限制策略纳入代谢营养路径。", "sources": [ "SRC-979" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、代谢健康与饮食干预", "notes": "第 177 轮补录：代谢营养与禁食；待本地复核。；日期补齐：Crossref 2025-06 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-369", "title": "《Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice》论文发表", "date_start": "2023-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕代谢营养与禁食报告异亮氨酸饮食限制延长遗传异质小鼠健康寿命。", "summary": "该节点将异亮氨酸限制证据纳入饮食干预路径。", "sources": [ "SRC-980" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、代谢健康与饮食干预", "notes": "第 177 轮补录：代谢营养与禁食；待本地复核。；日期补齐：Crossref 2023-11 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-303", "title": "《Psychological Resilience and Frailty Progression in Older Adults》论文发表", "date_start": "2024-11-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕心理韧性与社会支持报告或讨论可复核的学术证据。", "summary": "该节点将心理韧性与社会支持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-981" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理韧性、社会支持与主体持续性", "notes": "第 178 轮补录：心理韧性与社会支持；待本地复核。；日期补齐：Crossref 2024-11-25 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-304", "title": "《Effects of social support on cognitive frailty among the older adults in China: mediation of psychological resilience and moderated mediation of education》论文发表", "date_start": "2025-05-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕心理韧性与社会支持报告或讨论可复核的学术证据。", "summary": "该节点将心理韧性与社会支持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-982" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理韧性、社会支持与主体持续性", "notes": "第 178 轮补录：心理韧性与社会支持；待本地复核。；日期补齐：Crossref 2025-05-16 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-305", "title": "《Social Isolation and Loneliness in Older Adults》论文发表", "date_start": "2024-06-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕心理韧性与社会支持报告或讨论可复核的学术证据。", "summary": "该节点将心理韧性与社会支持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-983" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理韧性、社会支持与主体持续性", "notes": "第 178 轮补录：心理韧性与社会支持；待本地复核。；日期补齐：Crossref 2024-06-18 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-306", "title": "《Loneliness and Social Isolation Among US Older Adults》论文发表", "date_start": "2025-01-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕心理韧性与社会支持报告或讨论可复核的学术证据。", "summary": "该节点将心理韧性与社会支持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-984" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理韧性、社会支持与主体持续性", "notes": "第 178 轮补录：心理韧性与社会支持；待本地复核。；日期补齐：Crossref 2025-01-21 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-307", "title": "《RETRACTED: Personality Traits and Social Isolation in Older Adults》论文发表", "date_start": "2026-05-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕心理韧性与社会支持报告或讨论可复核的学术证据。", "summary": "该节点将心理韧性与社会支持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-985" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理韧性、社会支持与主体持续性", "notes": "第 178 轮补录：心理韧性与社会支持；待本地复核。；日期补齐：Crossref 2026-05-06 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-308", "title": "《Post–Intensive Care Syndrome and Caregiver Burden》论文发表", "date_start": "2025-04-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕照护劳动力与长期照护报告或讨论可复核的学术证据。", "summary": "该节点将照护劳动力与长期照护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-986" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "照护劳动力、长期照护与家庭照护", "notes": "第 179 轮补录：照护劳动力与长期照护；待本地复核。；日期补齐：Crossref 2025-04-08 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-309", "title": "《Use of Caregiving Support Services Among Diverse Dementia Caregivers by Geographic Context》论文发表", "date_start": "2023-06-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕照护劳动力与长期照护报告不同地区痴呆照护者支持服务使用。", "summary": "该节点将照护者服务使用纳入长期照护路径。", "sources": [ "SRC-987" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "照护劳动力、长期照护与家庭照护", "notes": "第 179 轮补录：照护劳动力与长期照护；待本地复核。；日期补齐：Crossref 2023-06-15 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-310", "title": "《Empowering a person-centered long-term care workforce》论文发表", "date_start": "2024-07-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕照护劳动力与长期照护讨论以人为中心的长期照护劳动力建设。", "summary": "该节点将长期照护劳动力建设纳入照护路径。", "sources": [ "SRC-988" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "照护劳动力、长期照护与家庭照护", "notes": "第 179 轮补录：照护劳动力与长期照护；待本地复核。；日期补齐：Crossref 2024-07-18 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-311", "title": "《Providing long-term care: Options for a better workforce》论文发表", "date_start": "2022-09-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕照护劳动力与长期照护讨论改善长期照护劳动力供给的选项。", "summary": "该节点将长期照护劳动力政策纳入照护路径。", "sources": [ "SRC-989" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "照护劳动力、长期照护与家庭照护", "notes": "第 179 轮补录：照护劳动力与长期照护；待本地复核。；日期补齐：Crossref 2022-09-26 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-312", "title": "《Influence of caregiver burden on well-being of family member caregivers of older adults》论文发表", "date_start": "2019-03-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕照护劳动力与长期照护报告家庭照护者负担对幸福感的影响。", "summary": "该节点将照护者负担纳入家庭照护路径。", "sources": [ "SRC-990" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "照护劳动力、长期照护与家庭照护", "notes": "第 179 轮补录：照护劳动力与长期照护；待本地复核。；日期补齐：Crossref 2019-03-10 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-313", "title": "《LGBTQ older adults deserve safe and affirming housing》论文发表", "date_start": "2024-10-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕住房与社区环境报告或讨论可复核的学术证据。", "summary": "该节点将住房与社区环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-991" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "住房、社区环境与建成环境韧性", "notes": "第 180 轮补录：住房与社区环境；待本地复核。；日期补齐：Crossref 2024-10-15 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-314", "title": "《Health and Economic Impacts of Stable Housing Provision for Older Adults》论文发表", "date_start": "2026-04-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕住房与社区环境报告稳定住房供给对老年人的健康与经济影响。", "summary": "该节点将稳定住房证据纳入环境韧性路径。", "sources": [ "SRC-992" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "住房、社区环境与建成环境韧性", "notes": "第 180 轮补录：住房与社区环境；待本地复核。；日期补齐：Crossref 2026-04-10 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-315", "title": "《Neighborhood environment and older adults' mental wellbeing and cognition: mediating role of activity variety》论文发表", "date_start": "2025-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕住房与社区环境报告社区环境通过活动多样性影响老年人认知与幸福。", "summary": "该节点将社区环境中介证据纳入建成环境路径。", "sources": [ "SRC-993" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "住房、社区环境与建成环境韧性", "notes": "第 180 轮补录：住房与社区环境；待本地复核。；日期补齐：Crossref 2025-10 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-316", "title": "《If You've Seen One Age-Friendly Community, You've Seen One Age-Friendly Community》论文发表", "date_start": "2019-04-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕住房与社区环境讨论老年友好社区多样性与评估。", "summary": "该节点将老年友好社区多样性纳入建成环境路径。", "sources": [ "SRC-994" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "住房、社区环境与建成环境韧性", "notes": "第 180 轮补录：住房与社区环境；待本地复核。；日期补齐：Crossref 2019-04-29 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-317", "title": "《Urban environment and mental wellbeing in Belgian older adults by neighborhood income level》论文发表", "date_start": "2025-10-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕住房与社区环境报告城市环境与比利时老年人心理幸福感的收入分层关联。", "summary": "该节点将城市环境分层证据纳入社区环境路径。", "sources": [ "SRC-995" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "住房、社区环境与建成环境韧性", "notes": "第 180 轮补录：住房与社区环境；待本地复核。；日期补齐：Crossref 2025-10-27 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-370", "title": "《Patient-Centered Data Home: A Path Towards National Interoperability》论文发表", "date_start": "2022-07-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该文献围绕健康数据互操作提出以患者为中心的数据家实现国家互操作。", "summary": "该节点将患者数据家纳入健康数据互操作路径。", "sources": [ "SRC-996" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康数据、互操作与患者数据连续性", "notes": "第 181 轮补录：健康数据互操作；待本地复核。；日期补齐：Crossref 2022-07-13 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-371", "title": "《Utilization of an Electronic Health Record Embedded Enterprise Health Data Exchange: A Single Institute Experience》论文发表", "date_start": "2025-03-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究围绕健康数据互操作报告机构级电子健康记录数据交换经验。", "summary": "该节点将机构数据交换纳入互操作路径。", "sources": [ "SRC-997" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康数据、互操作与患者数据连续性", "notes": "第 181 轮补录：健康数据互操作；待本地复核。；日期补齐：Crossref 2025-03-03 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-372", "title": "《Automating Electronic Health Record Data Quality Assessment》论文发表", "date_start": "2023-02-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究围绕健康数据互操作报告电子健康记录数据质量评估自动化。", "summary": "该节点将数据质量自动化纳入健康数据路径。", "sources": [ "SRC-998" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康数据、互操作与患者数据连续性", "notes": "第 181 轮补录：健康数据互操作；待本地复核。；日期补齐：Crossref 2023-02-13 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-373", "title": "《Electronic health record data for antimicrobial prescribing》论文发表", "date_start": "2021-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该文献围绕健康数据互操作讨论电子健康记录数据用于抗菌药物处方。", "summary": "该节点将 EHR 数据应用纳入健康数据路径。", "sources": [ "SRC-999" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康数据、互操作与患者数据连续性", "notes": "第 181 轮补录：健康数据互操作；待本地复核。；日期补齐：Crossref 2021-02 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-374", "title": "《MediTrans—Patient-centric interoperability through blockchain》论文发表", "date_start": "2021-09-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该研究围绕健康数据互操作提出基于区块链的患者中心互操作方案。", "summary": "该节点将区块链互操作纳入健康数据路径。", "sources": [ "SRC-1000" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康数据、互操作与患者数据连续性", "notes": "第 181 轮补录：健康数据互操作；待本地复核。；日期补齐：Crossref 2021-09-07 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-318", "title": "《Synthetic Data and Health Privacy》论文发表", "date_start": "2025-02-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕隐私与神经数据治理报告或讨论可复核的学术证据。", "summary": "该节点将隐私与神经数据治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1001" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康与神经数据隐私治理", "notes": "第 182 轮补录：隐私与神经数据治理；待本地复核。；日期补齐：Crossref 2025-02-18 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-319", "title": "《Toward owner governance in genomic data privacy with Governome》论文发表", "date_start": "2025-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕隐私与神经数据治理报告或讨论可复核的学术证据。", "summary": "该节点将隐私与神经数据治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1002" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康与神经数据隐私治理", "notes": "第 182 轮补录：隐私与神经数据治理；待本地复核。；日期补齐：Crossref 2025-09 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-320", "title": "《Health data justice: building new norms for health data governance》论文发表", "date_start": "2023-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕隐私与神经数据治理报告或讨论可复核的学术证据。", "summary": "该节点将隐私与神经数据治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1003" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康与神经数据隐私治理", "notes": "第 182 轮补录：隐私与神经数据治理；待本地复核。；日期补齐：Crossref 2023-02-28 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-321", "title": "《Data Governance and Distribution of Biobank: A Case from a Chinese Cancer Hospital》论文发表", "date_start": "2025-08-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕隐私与神经数据治理报告或讨论可复核的学术证据。", "summary": "该节点将隐私与神经数据治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1004" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康与神经数据隐私治理", "notes": "第 182 轮补录：隐私与神经数据治理；待本地复核。；日期补齐：Crossref 2025-08-19 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-322", "title": "《Prospective study design and data analysis in UK Biobank》论文发表", "date_start": "2024-01-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕隐私与神经数据治理报告或讨论可复核的学术证据。", "summary": "该节点将隐私与神经数据治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1005" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康与神经数据隐私治理", "notes": "第 182 轮补录：隐私与神经数据治理；待本地复核。；日期补齐：Crossref 2024-01-10 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-323", "title": "《Climate Change and Mental Health》论文发表", "date_start": "2024-05-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕气候灾害韧性报告或讨论可复核的学术证据。", "summary": "该节点将气候灾害韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1006" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "气候、灾害与主体环境韧性", "notes": "第 183 轮补录：气候灾害韧性；待本地复核。；日期补齐：Crossref 2024-05-28 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-324", "title": "《Addressing the Health Impacts of Climate Change in Older Adults》论文发表", "date_start": "2025-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕气候灾害韧性讨论应对气候变化对老年人健康的影响。", "summary": "该节点将气候健康影响纳入环境韧性路径。", "sources": [ "SRC-1007" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "气候、灾害与主体环境韧性", "notes": "第 183 轮补录：气候灾害韧性；待本地复核。；日期补齐：Crossref 2025-04-01 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-325", "title": "《Climate Change, Extreme Heat, and Health》论文发表", "date_start": "2024-05-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕气候灾害韧性综述极端高温与健康影响。", "summary": "该节点将极端高温健康证据纳入环境韧性路径。", "sources": [ "SRC-1008" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "气候、灾害与主体环境韧性", "notes": "第 183 轮补录：气候灾害韧性；待本地复核。；日期补齐：Crossref 2024-05-16 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-326", "title": "《Factors influencing disaster preparedness behaviors of older adults》论文发表", "date_start": "2025-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕气候灾害韧性报告影响老年人灾害准备行为的因素。", "summary": "该节点将老年灾害准备纳入环境韧性路径。", "sources": [ "SRC-1009" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "气候、灾害与主体环境韧性", "notes": "第 183 轮补录：气候灾害韧性；待本地复核。；日期补齐：Crossref 2025-02-28 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-327", "title": "《Addressing the Health Risks of Climate Change in Older Adults》论文发表", "date_start": "2019-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕气候灾害韧性讨论老年人气候健康风险。", "summary": "该节点将老年气候风险纳入环境韧性路径。", "sources": [ "SRC-1010" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "气候、灾害与主体环境韧性", "notes": "第 183 轮补录：气候灾害韧性；待本地复核。；日期补齐：Crossref 2019-11 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-328", "title": "《Reproducibility and robustness of economics and political science research》论文发表", "date_start": "2026-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕开放科学可复现报告或讨论可复核的学术证据。", "summary": "该节点将开放科学可复现的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1011" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "开放科学、可复现研究与证据治理", "notes": "第 184 轮补录：开放科学可复现；待本地复核。；日期补齐：Crossref 2026-04-01 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-329", "title": "《Balancing ethical data sharing and open science for reproducible research in biomedical data science》论文发表", "date_start": "2025-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕开放科学可复现报告或讨论可复核的学术证据。", "summary": "该节点将开放科学可复现的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1012" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "开放科学、可复现研究与证据治理", "notes": "第 184 轮补录：开放科学可复现；待本地复核。；日期补齐：Crossref 2025-04 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-330", "title": "《Reproducibility Failure in Biomedical Research: Problems and Solutions》论文发表", "date_start": "2026-01-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕开放科学可复现讨论生物医学研究复现失败问题与解决方案。", "summary": "该节点将复现失败治理纳入开放科学路径。", "sources": [ "SRC-1013" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "开放科学、可复现研究与证据治理", "notes": "第 184 轮补录：开放科学可复现；待本地复核。；日期补齐：Crossref 2026-01-27 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-331", "title": "《Biomedical researchers' perspectives on the reproducibility of research》论文发表", "date_start": "2024-11-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕开放科学可复现报告生物医学研究者对研究复现性的看法。", "summary": "该节点将研究者复现视角纳入开放科学路径。", "sources": [ "SRC-1014" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "开放科学、可复现研究与证据治理", "notes": "第 184 轮补录：开放科学可复现；待本地复核。；日期补齐：Crossref 2024-11-05 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-332", "title": "《Recommendations to enhance rigor and reproducibility in biomedical research》论文发表", "date_start": "2020-06-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕开放科学可复现提出增强生物医学研究严谨性与复现性的建议。", "summary": "该节点将复现建议纳入开放科学路径。", "sources": [ "SRC-1015" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "开放科学、可复现研究与证据治理", "notes": "第 184 轮补录：开放科学可复现；待本地复核。；日期补齐：Crossref 2020-06-01 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-333", "title": "《Associations between days spent at home and patient‐reported outcomes among frail older adults》论文发表", "date_start": "2023-04-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕功能指标与患者报告结局报告或讨论可复核的学术证据。", "summary": "该节点将功能指标与患者报告结局的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1016" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "功能状态、患者报告结局与健康寿命测量", "notes": "第 185 轮补录：功能指标与患者报告结局；待本地复核。；日期补齐：Crossref 2023-04-19 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-334", "title": "《Differences in phenotypic and functional aging trajectories among people aging with disability and the US general population》论文发表", "date_start": "2025-06-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕功能指标与患者报告结局比较残疾人群与普通人群功能衰老轨迹。", "summary": "该节点将功能衰老轨迹纳入健康寿命测量路径。", "sources": [ "SRC-1017" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "功能状态、患者报告结局与健康寿命测量", "notes": "第 185 轮补录：功能指标与患者报告结局；待本地复核。；日期补齐：Crossref 2025-06-24 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-335", "title": "《Disability: measurement matters》论文发表", "date_start": "2021-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕功能指标与患者报告结局讨论残疾测量方法的重要性。", "summary": "该节点将残疾测量方法纳入功能指标路径。", "sources": [ "SRC-1018" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "功能状态、患者报告结局与健康寿命测量", "notes": "第 185 轮补录：功能指标与患者报告结局；待本地复核。；日期补齐：Crossref 2021-08 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-336", "title": "《Handgrip Strength Asymmetry and Weakness Together Are Associated With Functional Disability in Aging Americans》论文发表", "date_start": "2020-04-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕功能指标与患者报告结局报告握力不对称与无力共同关联功能残疾。", "summary": "该节点将握力指标纳入功能状态路径。", "sources": [ "SRC-1019" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "功能状态、患者报告结局与健康寿命测量", "notes": "第 185 轮补录：功能指标与患者报告结局；待本地复核。；日期补齐：Crossref 2020-04-22 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-337", "title": "《Oral Health-Related Quality Of Life In Older Adults》论文发表", "date_start": "2025-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕功能指标与患者报告结局报告老年人口腔健康相关生活质量。", "summary": "该节点将口腔生活质量纳入功能指标路径。", "sources": [ "SRC-1020" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "功能状态、患者报告结局与健康寿命测量", "notes": "第 185 轮补录：功能指标与患者报告结局；待本地复核。；日期补齐：Crossref 2025-10 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-338", "title": "《Palliative care use in Taiwanese older adults》论文发表", "date_start": "2025-03-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕安宁疗护与死亡质量报告台湾老年人安宁疗护使用情况。", "summary": "该节点将安宁疗护使用证据纳入死亡质量路径。", "sources": [ "SRC-1021" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "安宁疗护、死亡质量与临终选择", "notes": "第 186 轮补录：安宁疗护与死亡质量；待本地复核。；日期补齐：Crossref 2025-03-11 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-339", "title": "《Advance Care Planning, End-of-Life Preferences, and Burdensome Care》论文发表", "date_start": "2025-02-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该研究围绕安宁疗护与死亡质量报告预先照护计划与临终负担照护。", "summary": "该节点将预先照护计划纳入临终选择路径。", "sources": [ "SRC-1022" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "安宁疗护、死亡质量与临终选择", "notes": "第 186 轮补录：安宁疗护与死亡质量；待本地复核。；日期补齐：Crossref 2025-02-01 (published-print, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-340", "title": "《Palliative care considerations in frail older adults》论文发表", "date_start": "2024-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕安宁疗护与死亡质量讨论衰弱老年人的安宁疗护考虑。", "summary": "该节点将衰弱老年人安宁疗护纳入死亡质量路径。", "sources": [ "SRC-1023" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "安宁疗护、死亡质量与临终选择", "notes": "第 186 轮补录：安宁疗护与死亡质量；待本地复核。；日期补齐：Crossref 2024-07 (published-online, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-341", "title": "《Palliative care for older adults with cardiovascular disease》论文发表", "date_start": "2024-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕安宁疗护与死亡质量讨论心血管病老年人的安宁疗护。", "summary": "该节点将心血管安宁疗护纳入死亡质量路径。", "sources": [ "SRC-1024" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "安宁疗护、死亡质量与临终选择", "notes": "第 186 轮补录：安宁疗护与死亡质量；待本地复核。；日期补齐：Crossref 2024-07 (published-online, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-342", "title": "《Hospice and Palliative Care》论文发表", "date_start": "2020-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕安宁疗护与死亡质量综述临终关怀与安宁疗护。", "summary": "该节点将临终关怀综述纳入死亡质量路径。", "sources": [ "SRC-1025" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "安宁疗护、死亡质量与临终选择", "notes": "第 186 轮补录：安宁疗护与死亡质量；待本地复核。；日期补齐：Crossref 2020-05 (published-print, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-343", "title": "《Personal identity is social identity》论文发表", "date_start": "2020-09-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕生命伦理与身份连续性论证个人身份即社会身份。", "summary": "该节点将社会身份理论纳入主体连续性路径。", "sources": [ "SRC-1026" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生命伦理、身份连续性与主体哲学", "notes": "第 187 轮补录：生命伦理与身份连续性；待本地复核。；日期补齐：Crossref 2020-09-04 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-344", "title": "《Self-identity and personal identity》论文发表", "date_start": "2020-08-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕生命伦理与身份连续性区分自我认同与个人身份。", "summary": "该节点将自我认同理论纳入主体连续性路径。", "sources": [ "SRC-1027" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生命伦理、身份连续性与主体哲学", "notes": "第 187 轮补录：生命伦理与身份连续性；待本地复核。；日期补齐：Crossref 2020-08-07 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-345", "title": "《Is personal identity intransitive?》论文发表", "date_start": "2025-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该研究围绕生命伦理与身份连续性检验个人身份是否可传递。", "summary": "该节点将身份传递实验纳入主体连续性路径。", "sources": [ "SRC-1028" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生命伦理、身份连续性与主体哲学", "notes": "第 187 轮补录：生命伦理与身份连续性；待本地复核。；日期补齐：Crossref 2025-03 (published-online, month, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-346", "title": "《Narrative and Personal Identity》论文发表", "date_start": "2022-05-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕生命伦理与身份连续性讨论叙事与个人身份。", "summary": "该节点将叙事身份纳入主体连续性路径。", "sources": [ "SRC-1029" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生命伦理、身份连续性与主体哲学", "notes": "第 187 轮补录：生命伦理与身份连续性；待本地复核。；日期补齐：Crossref 2022-05-31 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-347", "title": "《Personal Identity and National Identity: An Analogy》论文发表", "date_start": "2020-01-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕生命伦理与身份连续性类比个人身份与民族身份。", "summary": "该节点将身份类比纳入主体连续性路径。", "sources": [ "SRC-1030" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生命伦理、身份连续性与主体哲学", "notes": "第 187 轮补录：生命伦理与身份连续性；待本地复核。；日期补齐：Crossref 2020-01-02 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-348", "title": "《Implausibility of radical life extension in humans in the twenty-first century》论文发表", "date_start": "2024-10-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论论证本世纪激进延寿不可信。", "summary": "该节点将激进延寿反证纳入长寿逃逸速度理论路径。", "sources": [ "SRC-1031" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度与激进延寿理论", "notes": "第 188 轮补录：长寿逃逸速度理论；待本地复核。；日期补齐：Crossref 2024-10-07 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-349", "title": "《Healthspan versus lifespan: new medicines to close the gap》论文发表", "date_start": "2022-11-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论讨论缩小健康寿命与寿命差距的新药。", "summary": "该节点将健康寿命-寿命差距药物纳入长寿理论路径。", "sources": [ "SRC-1032" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度与激进延寿理论", "notes": "第 188 轮补录：长寿逃逸速度理论；待本地复核。；日期补齐：Crossref 2022-11-09 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-350", "title": "《Healthspan-lifespan gap differs in magnitude and disease contribution across world regions》论文发表", "date_start": "2025-09-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该研究围绕长寿逃逸速度理论报告不同地区健康寿命-寿命差距与疾病贡献差异。", "summary": "该节点将全球健康寿命差距纳入长寿理论路径。", "sources": [ "SRC-1033" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度与激进延寿理论", "notes": "第 188 轮补录：长寿逃逸速度理论；待本地复核。；日期补齐：Crossref 2025-09-01 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-351", "title": "《The Ethics of Radical Life Extension: Catholic, Protestant, Orthodox Christian, and Global Ethic Perspectives》论文发表", "date_start": "2021", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论讨论激进延寿的宗教伦理。", "summary": "该节点将激进延寿伦理纳入长寿理论路径。", "sources": [ "SRC-1034" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度与激进延寿理论", "notes": "第 188 轮补录：长寿逃逸速度理论；待本地复核。；日期补齐：Crossref 2021 (published-online, year, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-352", "title": "《Forever is Always Finite: Reflections on Radical Life Extension》论文发表", "date_start": "2019-03-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论反思激进延寿的有限性。", "summary": "该节点将激进延寿反思纳入长寿理论路径。", "sources": [ "SRC-1035" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度与激进延寿理论", "notes": "第 188 轮补录：长寿逃逸速度理论；待本地复核。；日期补齐：Crossref 2019-03-23 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-353", "title": "《Synthetic biology》论文发表", "date_start": "2023-03-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕合成生物学生物安全报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学生物安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1036" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "合成生物学、生物安全与双重用途", "notes": "第 189 轮补录：合成生物学生物安全；待本地复核。；日期补齐：Crossref 2023-03-15 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-354", "title": "《Quantitative synthetic biology》论文发表", "date_start": "2024-07-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕合成生物学生物安全报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学生物安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1037" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "合成生物学、生物安全与双重用途", "notes": "第 189 轮补录：合成生物学生物安全；待本地复核。；日期补齐：Crossref 2024-07-24 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-355", "title": "《Decoding the origins of cellular self-organization for engineered biology》论文发表", "date_start": "2026-06-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕合成生物学生物安全报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学生物安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1038" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "合成生物学、生物安全与双重用途", "notes": "第 189 轮补录：合成生物学生物安全；待本地复核。；日期补齐：Crossref 2026-06-01 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-356", "title": "《Exploring the Application and Prospects of Synthetic Biology in Engineered Living Materials》论文发表", "date_start": "2023-11-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕合成生物学生物安全报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学生物安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1039" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "合成生物学、生物安全与双重用途", "notes": "第 189 轮补录：合成生物学生物安全；待本地复核。；日期补齐：Crossref 2023-11-29 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-357", "title": "《Building biosecurity for synthetic biology》论文发表", "date_start": "2020-07-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕合成生物学生物安全提出建立合成生物学生物安全体系的框架。", "summary": "该节点将合成生物学生物安全建设纳入双重用途治理路径。", "sources": [ "SRC-1040" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "合成生物学、生物安全与双重用途", "notes": "第 189 轮补录：合成生物学生物安全；待本地复核。；日期补齐：Crossref 2020-07-21 (published-online, day, v3)", "created_at": "2026-08-06T17:01:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-375", "title": "《Technology Roadmap of Micro/Nanorobots》论文发表", "date_start": "2025-06-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米机器与分子修复报告或讨论可复核的学术证据。", "summary": "该节点将纳米机器与分子修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1041" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米机器、分子修复与医学纳米技术", "notes": "第 190 轮补录：纳米机器与分子修复；待本地复核。；日期补齐：Crossref 2025-06-27 (published-online, day, v3)", "created_at": "2026-08-06T17:02:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-376", "title": "《Janus Micro/Nanorobots in Biomedical Applications》论文发表", "date_start": "2022-11-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米机器与分子修复综述 Janus 微纳机器人在生物医学中的应用。", "summary": "该节点将 Janus 微纳机器人纳入分子修复路径。", "sources": [ "SRC-1042" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米机器、分子修复与医学纳米技术", "notes": "第 190 轮补录：纳米机器与分子修复；待本地复核。；日期补齐：Crossref 2022-11-29 (published-online, day, v3)", "created_at": "2026-08-06T17:02:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-377", "title": "《AI-enhanced biomedical micro/nanorobots in microfluidics》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米机器与分子修复讨论 AI 增强微纳机器人与微流控。", "summary": "该节点将 AI 微纳机器人纳入分子修复路径。", "sources": [ "SRC-1043" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米机器、分子修复与医学纳米技术", "notes": "第 190 轮补录：纳米机器与分子修复；待本地复核。；日期补齐：Crossref 2024 (published-online, year, v3)", "created_at": "2026-08-06T17:02:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-378", "title": "《Microenvironment-responsive nanorobots for biomedical applications》论文发表", "date_start": "2026-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米机器与分子修复综述微环境响应纳米机器人。", "summary": "该节点将微环境响应纳米机器人纳入分子修复路径。", "sources": [ "SRC-1044" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米机器、分子修复与医学纳米技术", "notes": "第 190 轮补录：纳米机器与分子修复；待本地复核。；日期补齐：Crossref 2026-04 (published-print, month, v3)", "created_at": "2026-08-06T17:02:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-379", "title": "《Micro/nanomotors in targeted drug delivery: Advances, challenges, and future directions》论文发表", "date_start": "2025-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米机器与分子修复综述微纳马达靶向递药进展与挑战。", "summary": "该节点将微纳马达递药纳入分子修复路径。", "sources": [ "SRC-1045" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米机器、分子修复与医学纳米技术", "notes": "第 190 轮补录：纳米机器与分子修复；待本地复核。；日期补齐：Crossref 2025-04 (published-print, month, v3)", "created_at": "2026-08-06T17:02:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-380", "title": "《Decoding motor plans using a closed-loop ultrasonic brain–machine interface》论文发表", "date_start": "2023-11-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口运动重建报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口运动重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1046" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、言语解码与运动重建", "notes": "第 191 轮补录：脑机接口运动重建；待本地复核。；日期补齐：Crossref 2023-11-30 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-381", "title": "《A Novel Brain–Computer Interface Application: Precise Decoding of Urination and Defecation Motor Attempts in Spinal Cord Injury Patients》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口运动重建报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口运动重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1047" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、言语解码与运动重建", "notes": "第 191 轮补录：脑机接口运动重建；待本地复核。；日期补齐：Crossref 2026 (published-print, year, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-382", "title": "《Feasibility of decoding cerebellar movement-related potentials for brain-computer interface applications》论文发表", "date_start": "2025-11-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口运动重建报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口运动重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1048" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、言语解码与运动重建", "notes": "第 191 轮补录：脑机接口运动重建；待本地复核。；日期补齐：Crossref 2025-11-12 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-383", "title": "《Decoding trajectories of imagined hand movement using electrocorticograms for brain–machine interface》论文发表", "date_start": "2022-09-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口运动重建报告皮层脑电图解码想象手部运动轨迹。", "summary": "该节点将想象手部运动解码纳入脑机接口运动重建路径。", "sources": [ "SRC-1049" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、言语解码与运动重建", "notes": "第 191 轮补录：脑机接口运动重建；待本地复核。；日期补齐：Crossref 2022-09-07 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-384", "title": "《Motor Imagery Hand Movement Direction Decoding Using Brain Computer Interface to Aid Stroke Recovery and Rehabilitation》论文发表", "date_start": "2020-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕脑机接口运动重建报告运动想象手部方向解码辅助卒中康复。", "summary": "该节点将运动想象解码纳入脑机接口康复路径。", "sources": [ "SRC-1050" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、言语解码与运动重建", "notes": "第 191 轮补录：脑机接口运动重建；待本地复核。；日期补齐：Crossref 2020-12 (published-print, month, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-358", "title": "《Cryonics for all?》论文发表", "date_start": "2020-02-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "该文献围绕脑保存与意识伦理讨论冷冻保存是否应面向所有人。", "summary": "该节点将冷冻保存可及性伦理纳入脑保存路径。", "sources": [ "SRC-1051" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存、意识恢复与未来伦理", "notes": "第 192 轮补录：脑保存与意识伦理；待本地复核。；日期补齐：Crossref 2020-02-09 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-359", "title": "《Cryonics: Traps and transformations》论文发表", "date_start": "2024-02-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "该文献围绕脑保存与意识伦理讨论冷冻保存的陷阱与转变。", "summary": "该节点将冷冻保存伦理陷阱纳入脑保存路径。", "sources": [ "SRC-1052" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存、意识恢复与未来伦理", "notes": "第 192 轮补录：脑保存与意识伦理；待本地复核。；日期补齐：Crossref 2024-02-29 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-360", "title": "《Selective Optimism about Mind-Uploading》论文发表", "date_start": "2025-02-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "该文献围绕脑保存与意识伦理讨论意识上传的选择性乐观。", "summary": "该节点将意识上传哲学纳入数字迁移路径。", "sources": [ "SRC-1053" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存、意识恢复与未来伦理", "notes": "第 192 轮补录：脑保存与意识伦理；待本地复核。；日期补齐：Crossref 2025-02-01 (published-print, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-361", "title": "《Mind Uploading and Embodied Cognition: A Theological Response》论文发表", "date_start": "2019-03-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "该文献围绕脑保存与意识伦理从具身认知视角回应意识上传。", "summary": "该节点将具身认知回应纳入脑保存伦理路径。", "sources": [ "SRC-1054" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存、意识恢复与未来伦理", "notes": "第 192 轮补录：脑保存与意识伦理；待本地复核。；日期补齐：Crossref 2019-03-02 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-362", "title": "《The ethics of preservation: Balancing clinical utility and duty in catastrophic brain injury》论文发表", "date_start": "2026-05-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "thought", "claim": "该文献围绕脑保存与意识伦理讨论灾难性脑损伤中的保存伦理与临床义务。", "summary": "该节点将脑损伤保存伦理纳入脑保存路径。", "sources": [ "SRC-1055" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑保存、意识恢复与未来伦理", "notes": "第 192 轮补录：脑保存与意识伦理；待本地复核。；日期补齐：Crossref 2026-05-05 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-385", "title": "《Neurosymbolic Digital Twin for Cardiovascular Disease Prediction and Personalized Modeling》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕数字孪生预测医学报告心血管疾病预测的神经符号数字孪生。", "summary": "该节点将心血管数字孪生纳入预测医学路径。", "sources": [ "SRC-1056" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、预测医学与个体决策", "notes": "第 193 轮补录：数字孪生预测医学；待本地复核。；日期补齐：Crossref 2025 (published-print, year, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-386", "title": "《DECIDE-Twin: A Framework for AI-Enabled Digital Twins in Clinical Decision-Making》论文发表", "date_start": "2025-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕数字孪生预测医学提出临床决策 AI 数字孪生框架。", "summary": "该节点将临床决策数字孪生纳入预测医学路径。", "sources": [ "SRC-1057" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、预测医学与个体决策", "notes": "第 193 轮补录：数字孪生预测医学；待本地复核。；日期补齐：Crossref 2025-09 (published-print, month, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-387", "title": "《A digital twin model for evidence-based clinical decision support in multiple myeloma treatment》论文发表", "date_start": "2023-12-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕数字孪生预测医学报告多发性骨髓瘤循证临床决策数字孪生模型。", "summary": "该节点将癌症治疗数字孪生纳入预测医学路径。", "sources": [ "SRC-1058" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、预测医学与个体决策", "notes": "第 193 轮补录：数字孪生预测医学；待本地复核。；日期补齐：Crossref 2023-12-20 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-388", "title": "《Hybrid disease prediction approach leveraging digital twin and metaverse technologies for health consumer》论文发表", "date_start": "2024-04-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕数字孪生预测医学报告数字孪生与元宇宙混合疾病预测方法。", "summary": "该节点将混合疾病预测纳入数字孪生路径。", "sources": [ "SRC-1059" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、预测医学与个体决策", "notes": "第 193 轮补录：数字孪生预测医学；待本地复核。；日期补齐：Crossref 2024-04-05 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-389", "title": "《Rheumatic Digital Twin: Proposed Machine Learning–Based Multimodal Framework to Inform Clinical Decision-Making》论文发表", "date_start": "2026-05-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该研究围绕数字孪生预测医学提出风湿病多模态数字孪生框架。", "summary": "该节点将风湿病数字孪生纳入预测医学路径。", "sources": [ "SRC-1060" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、预测医学与个体决策", "notes": "第 193 轮补录：数字孪生预测医学；待本地复核。；日期补齐：Crossref 2026-05-04 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-390", "title": "《Tissue Fibrosis Decoded via Cellular Senescence: Mechanisms, Treatments, and Emerging Technologies》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞衰老组织特异性报告或讨论可复核的学术证据。", "summary": "该节点将细胞衰老组织特异性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1061" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、组织特异性与器官维护", "notes": "第 194 轮补录：细胞衰老组织特异性；待本地复核。；日期补齐：Crossref 2025 (published-online, year, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-392", "title": "《Hypertension and cellular senescence》论文发表", "date_start": "2023-04-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞衰老组织特异性报告或讨论可复核的学术证据。", "summary": "该节点将细胞衰老组织特异性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1063" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、组织特异性与器官维护", "notes": "第 194 轮补录：细胞衰老组织特异性；待本地复核。；日期补齐：Crossref 2023-04-03 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-393", "title": "《Cellular senescence and glaucoma》论文发表", "date_start": "2025-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞衰老组织特异性报告或讨论可复核的学术证据。", "summary": "该节点将细胞衰老组织特异性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1064" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、组织特异性与器官维护", "notes": "第 194 轮补录：细胞衰老组织特异性；待本地复核。；日期补齐：Crossref 2025-04 (published-print, month, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-394", "title": "《Cellular senescence in ischemic stroke: Cell-type specificity, temporal dynamics, and response to therapeutic interventions》论文发表", "date_start": "2026-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞衰老组织特异性报告或讨论可复核的学术证据。", "summary": "该节点将细胞衰老组织特异性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1065" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、组织特异性与器官维护", "notes": "第 194 轮补录：细胞衰老组织特异性；待本地复核。；日期补齐：Crossref 2026-08 (published-print, month, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-395", "title": "《Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons》论文发表", "date_start": "2024-04-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体生物能量学报告或讨论可复核的学术证据。", "summary": "该节点将线粒体生物能量学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1066" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、生物能量学与能量韧性", "notes": "第 195 轮补录：线粒体生物能量学；待本地复核。；日期补齐：Crossref 2024-04-12 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-396", "title": "《Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed》论文发表", "date_start": "2025-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体生物能量学报告或讨论可复核的学术证据。", "summary": "该节点将线粒体生物能量学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1067" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、生物能量学与能量韧性", "notes": "第 195 轮补录：线粒体生物能量学；待本地复核。；日期补齐：Crossref 2025-07 (published-print, month, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-397", "title": "《Mitochondrial function and phenotype are defined by bioenergetics》论文发表", "date_start": "2023-08-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体生物能量学报告或讨论可复核的学术证据。", "summary": "该节点将线粒体生物能量学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1068" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、生物能量学与能量韧性", "notes": "第 195 轮补录：线粒体生物能量学；待本地复核。；日期补齐：Crossref 2023-08-21 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-398", "title": "《Mitochondrial quality control in human ageing and longevity》论文发表", "date_start": "2026-06-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体生物能量学报告或讨论可复核的学术证据。", "summary": "该节点将线粒体生物能量学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1069" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、生物能量学与能量韧性", "notes": "第 195 轮补录：线粒体生物能量学；待本地复核。；日期补齐：Crossref 2026-06-29 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-399", "title": "《Mitochondrial respiratory supercomplexes associated with longevity in mammals》论文发表", "date_start": "2026-07-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体生物能量学报告或讨论可复核的学术证据。", "summary": "该节点将线粒体生物能量学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1070" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、生物能量学与能量韧性", "notes": "第 195 轮补录：线粒体生物能量学；待本地复核。；日期补齐：Crossref 2026-07-29 (published-online, day, v3)", "created_at": "2026-08-06T17:04:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-400", "title": "《Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕免疫代谢疫苗报告或讨论可复核的学术证据。", "summary": "该节点将免疫代谢疫苗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1071" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫代谢、疫苗与免疫韧性", "notes": "第 196 轮补录：免疫代谢疫苗；待本地复核。；日期补齐：Crossref 2024 (published-print, year, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-401", "title": "《Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging》论文发表", "date_start": "2025-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕免疫代谢疫苗报告或讨论可复核的学术证据。", "summary": "该节点将免疫代谢疫苗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1072" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫代谢、疫苗与免疫韧性", "notes": "第 196 轮补录：免疫代谢疫苗；待本地复核。；日期补齐：Crossref 2025-07-01 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-402", "title": "《Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice》论文发表", "date_start": "2024-04-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该研究围绕免疫代谢疫苗报告接种前饮食切换改善曾肥胖小鼠免疫响应。", "summary": "该节点将饮食-免疫代谢干预纳入疫苗韧性路径。", "sources": [ "SRC-1073" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫代谢、疫苗与免疫韧性", "notes": "第 196 轮补录：免疫代谢疫苗；待本地复核。；日期补齐：Crossref 2024-04-18 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-403", "title": "《Obesity Dysregulates the Immune Response to Influenza Infection and Vaccination Through Metabolic and Inflammatory Mechanisms》论文发表", "date_start": "2022-08-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕免疫代谢疫苗综述肥胖通过代谢炎症机制干扰流感激活动免疫响应。", "summary": "该节点将肥胖免疫代谢机制纳入疫苗韧性路径。", "sources": [ "SRC-1074" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫代谢、疫苗与免疫韧性", "notes": "第 196 轮补录：免疫代谢疫苗；待本地复核。；日期补齐：Crossref 2022-08-22 (published-print, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-404", "title": "《Metabolic mediators: How immunometabolism directs the immune response to infection》论文发表", "date_start": "2020-10-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕免疫代谢疫苗讨论代谢介质如何引导感染免疫响应。", "summary": "该节点将免疫代谢介质纳入免疫韧性路径。", "sources": [ "SRC-1075" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫代谢、疫苗与免疫韧性", "notes": "第 196 轮补录：免疫代谢疫苗；待本地复核。；日期补齐：Crossref 2020-10-21 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-405", "title": "《Glial-derived mitochondrial signals affect neuronal proteostasis and aging》论文发表", "date_start": "2023-10-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白质稳态蛋白病报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质稳态蛋白病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1076" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态、蛋白病与细胞质量控制", "notes": "第 197 轮补录：蛋白质稳态蛋白病；待本地复核。；日期补齐：Crossref 2023-10-13 (published-print, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-406", "title": "《Central role of the ER proteostasis network in healthy aging》论文发表", "date_start": "2025-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白质稳态蛋白病报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质稳态蛋白病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1077" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态、蛋白病与细胞质量控制", "notes": "第 197 轮补录：蛋白质稳态蛋白病；待本地复核。；日期补齐：Crossref 2025-07 (published-print, month, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-407", "title": "《Aging-associated modulation of UFMylation impairs proteostasis in C. elegans》论文发表", "date_start": "2026-04-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白质稳态蛋白病报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质稳态蛋白病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1078" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态、蛋白病与细胞质量控制", "notes": "第 197 轮补录：蛋白质稳态蛋白病；待本地复核。；日期补齐：Crossref 2026-04-29 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-408", "title": "《Moderately cold temperatures prevent protein aggregation related to aging and disease》论文发表", "date_start": "2023-04-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白质稳态蛋白病报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质稳态蛋白病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1079" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态、蛋白病与细胞质量控制", "notes": "第 197 轮补录：蛋白质稳态蛋白病；待本地复核。；日期补齐：Crossref 2023-04-03 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-409", "title": "《The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation》论文发表", "date_start": "2025-09-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白质稳态蛋白病报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质稳态蛋白病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1080" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质稳态、蛋白病与细胞质量控制", "notes": "第 197 轮补录：蛋白质稳态蛋白病；待本地复核。；日期补齐：Crossref 2025-09-03 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-410", "title": "《Bioengineered human tissue regeneration and repair using endogenous stem cells》论文发表", "date_start": "2023-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕干细胞组织修复报告或讨论可复核的学术证据。", "summary": "该节点将干细胞组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1081" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞、组织修复与内源再生", "notes": "第 198 轮补录：干细胞组织修复；待本地复核。；日期补齐：Crossref 2023-08 (published-print, month, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-411", "title": "《Regenesis: Repair and regeneration reinvented in stem cell therapeutics》论文发表", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕干细胞组织修复报告或讨论可复核的学术证据。", "summary": "该节点将干细胞组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1082" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞、组织修复与内源再生", "notes": "第 198 轮补录：干细胞组织修复；待本地复核。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-412", "title": "《Apoptotic dysregulation mediates stem cell competition and tissue regeneration》论文发表", "date_start": "2023-11-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕干细胞组织修复报告或讨论可复核的学术证据。", "summary": "该节点将干细胞组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1083" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞、组织修复与内源再生", "notes": "第 198 轮补录：干细胞组织修复；待本地复核。；日期补齐：Crossref 2023-11-20 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-413", "title": "《Stem cell therapy might improve aging frailty》论文发表", "date_start": "2026-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕干细胞组织修复报告或讨论可复核的学术证据。", "summary": "该节点将干细胞组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1084" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞、组织修复与内源再生", "notes": "第 198 轮补录：干细胞组织修复；待本地复核。；日期补齐：Crossref 2026-04-01 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-414", "title": "《Mitochondrial drivers of stem cell aging and inflammaging》论文发表", "date_start": "2026-05-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕干细胞组织修复报告或讨论可复核的学术证据。", "summary": "该节点将干细胞组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1085" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞、组织修复与内源再生", "notes": "第 198 轮补录：干细胞组织修复；待本地复核。；日期补齐：Crossref 2026-05-28 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-415", "title": "《Organ-on-chip models for infectious disease research》论文发表", "date_start": "2024-03-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官芯片疾病模型综述器官芯片在传染病研究中的应用。", "summary": "该节点将传染病器官芯片纳入疾病模型路径。", "sources": [ "SRC-1086" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、微生理系统与疾病模型", "notes": "第 199 轮补录：器官芯片疾病模型；待本地复核。；日期补齐：Crossref 2024-03-25 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-416", "title": "《An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery》论文发表", "date_start": "2025-05-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该研究围绕器官芯片疾病模型报告十八器官微生理系统用于药物发现。", "summary": "该节点将多器官微生理系统纳入器官芯片路径。", "sources": [ "SRC-1087" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、微生理系统与疾病模型", "notes": "第 199 轮补录：器官芯片疾病模型；待本地复核。；日期补齐：Crossref 2025-05-14 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-417", "title": "《Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling》论文发表", "date_start": "2025-01-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官芯片疾病模型综述心脏芯片用于心血管疾病建模。", "summary": "该节点将心脏芯片纳入器官芯片路径。", "sources": [ "SRC-1088" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、微生理系统与疾病模型", "notes": "第 199 轮补录：器官芯片疾病模型；待本地复核。；日期补齐：Crossref 2025-01-30 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-418", "title": "《Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery》论文发表", "date_start": "2018-01-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官芯片疾病模型讨论微生理系统增强药物安全评估。", "summary": "该节点将微生理安全评估纳入器官芯片路径。", "sources": [ "SRC-1089" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、微生理系统与疾病模型", "notes": "第 199 轮补录：器官芯片疾病模型；待本地复核。；日期补齐：Crossref 2018-01-06 (published-print, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-419", "title": "《Microfluidic Organ-on-a-Chip Models of Human Intestine》论文发表", "date_start": "2018", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官芯片疾病模型综述人肠道微流控器官芯片模型。", "summary": "该节点将肠道器官芯片纳入疾病模型路径。", "sources": [ "SRC-1090" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、微生理系统与疾病模型", "notes": "第 199 轮补录：器官芯片疾病模型；待本地复核。；日期补齐：Crossref 2018 (published-print, year, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-363", "title": "《Rethinking research reproducibility》论文发表", "date_start": "2018-12-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕综合证据治理与门禁反思研究复现性问题。", "summary": "该节点将研究复现反思纳入证据治理路径。", "sources": [ "SRC-1091" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "综合证据治理、复现性与时间线门禁", "notes": "第 200 轮补录：综合证据治理与门禁；待本地复核。；日期补齐：Crossref 2018-12-05 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-364", "title": "《Reproducibility in Plant Research》论文发表", "date_start": "2023-05-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕综合证据治理与门禁讨论植物研究中的复现性实践。", "summary": "该节点将领域复现实践纳入证据治理路径。", "sources": [ "SRC-1092" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "综合证据治理、复现性与时间线门禁", "notes": "第 200 轮补录：综合证据治理与门禁；待本地复核。；日期补齐：Crossref 2023-05-03 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-365", "title": "《Research Lifecycle Management: Using Analysis Reproducibility Research Software to Define Contextual Data Governance Policies》论文发表", "date_start": "2025-07-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕综合证据治理与门禁提出研究生命周期与数据治理策略。", "summary": "该节点将研究生命周期数据治理纳入证据治理路径。", "sources": [ "SRC-1093" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "综合证据治理、复现性与时间线门禁", "notes": "第 200 轮补录：综合证据治理与门禁；待本地复核。；日期补齐：Crossref 2025-07-31 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-366", "title": "《Reproducibility in chemistry research》论文发表", "date_start": "2024-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕综合证据治理与门禁讨论化学研究复现性。", "summary": "该节点将化学复现实践纳入证据治理路径。", "sources": [ "SRC-1094" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "综合证据治理、复现性与时间线门禁", "notes": "第 200 轮补录：综合证据治理与门禁；待本地复核。；日期补齐：Crossref 2024-07 (published-print, month, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-367", "title": "《Adaptive data governance for research data management》论文发表", "date_start": "2025-03-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕综合证据治理与门禁提出研究数据管理自适应治理。", "summary": "该节点将自适应数据治理纳入证据治理路径。", "sources": [ "SRC-1095" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "综合证据治理、复现性与时间线门禁", "notes": "第 200 轮补录：综合证据治理与门禁；待本地复核。；日期补齐：Crossref 2025-03-27 (published-online, day, v3)", "created_at": "2026-08-06T17:04:13Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-420", "title": "《Gene therapy zeroes in on Parkinson disease brain circuits》论文发表", "date_start": "2023-12-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕帕金森细胞疗法报告或讨论可复核的学术证据。", "summary": "该节点将帕金森细胞疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1096" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞疗法、神经退行性疾病与运动功能重建", "notes": "第 201 轮补录：帕金森细胞疗法；待本地复核。；日期补齐：Crossref 2023-12-04 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-421", "title": "《New Addition to Parkinson Therapy》论文发表", "date_start": "2017-05-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕帕金森细胞疗法报告或讨论可复核的学术证据。", "summary": "该节点将帕金森细胞疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1097" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞疗法、神经退行性疾病与运动功能重建", "notes": "第 201 轮补录：帕金森细胞疗法；待本地复核。；日期补齐：Crossref 2017-05-02 (published-print, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-422", "title": "《Long-term Clinical Outcomes After Fetal Cell Transplantation in Parkinson Disease》论文发表", "date_start": "2014-02-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕帕金森细胞疗法报告或讨论可复核的学术证据。", "summary": "该节点将帕金森细胞疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1098" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞疗法、神经退行性疾病与运动功能重建", "notes": "第 201 轮补录：帕金森细胞疗法；待本地复核。；日期补齐：Crossref 2014-02-12 (published-print, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-423", "title": "《Multiplying Messages LRRK beneath Parkinson Disease》论文发表", "date_start": "2014-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕帕金森细胞疗法报告或讨论可复核的学术证据。", "summary": "该节点将帕金森细胞疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1099" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞疗法、神经退行性疾病与运动功能重建", "notes": "第 201 轮补录：帕金森细胞疗法；待本地复核。；日期补齐：Crossref 2014-04 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-424", "title": "《Research Yields Clues to Improving Cell Therapy for Parkinson Disease》论文发表", "date_start": "2002-01-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕帕金森细胞疗法报告或讨论可复核的学术证据。", "summary": "该节点将帕金森细胞疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1100" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞疗法、神经退行性疾病与运动功能重建", "notes": "第 201 轮补录：帕金森细胞疗法；待本地复核。；日期补齐：Crossref 2002-01-09 (published-print, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-425", "title": "《Single-cell chromatin accessibility landscape of cardiac non-myocytes identifies tissue repair program during heart regeneration》论文发表", "date_start": "2026-03-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕心脏再生与心肌修复报告或讨论可复核的学术证据。", "summary": "该节点将心脏再生与心肌修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1101" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心脏再生、心肌修复与循环系统重建", "notes": "第 202 轮补录：心脏再生与心肌修复；待本地复核。；日期补齐：Crossref 2026-03-05 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-426", "title": "《Epicardial FSTL1 reconstitution regenerates the adult mammalian heart》论文发表", "date_start": "2015-09-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕心脏再生与心肌修复报告或讨论可复核的学术证据。", "summary": "该节点将心脏再生与心肌修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1102" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心脏再生、心肌修复与循环系统重建", "notes": "第 202 轮补录：心脏再生与心肌修复；待本地复核。；日期补齐：Crossref 2015-09-16 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-427", "title": "《Transient Regenerative Potential of the Neonatal Mouse Heart》论文发表", "date_start": "2011-02-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕心脏再生与心肌修复报告或讨论可复核的学术证据。", "summary": "该节点将心脏再生与心肌修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1103" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心脏再生、心肌修复与循环系统重建", "notes": "第 202 轮补录：心脏再生与心肌修复；待本地复核。；日期补齐：Crossref 2011-02-25 (published-print, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-428", "title": "《Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair》论文发表", "date_start": "2013-07-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕心脏再生与心肌修复报告或讨论可复核的学术证据。", "summary": "该节点将心脏再生与心肌修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1104" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心脏再生、心肌修复与循环系统重建", "notes": "第 202 轮补录：心脏再生与心肌修复；待本地复核。；日期补齐：Crossref 2013-07-10 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-429", "title": "《Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease》论文发表", "date_start": "2021", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕心脏再生与心肌修复报告或讨论可复核的学术证据。", "summary": "该节点将心脏再生与心肌修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1105" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心脏再生、心肌修复与循环系统重建", "notes": "第 202 轮补录：心脏再生与心肌修复；待本地复核。；日期补齐：Crossref 2021 (published-print, year, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-430", "title": "《Versican expression from lung fibroblasts suppresses pulmonary fibrosis》论文发表", "date_start": "2026-01-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肺再生与慢性肺病报告或讨论可复核的学术证据。", "summary": "该节点将肺再生与慢性肺病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1106" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肺再生、慢性肺病与呼吸系统重建", "notes": "第 203 轮补录：肺再生与慢性肺病；待本地复核。；日期补齐：Crossref 2026-01-21 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-431", "title": "《Lung cell transplantation for pulmonary fibrosis》论文发表", "date_start": "2024-08-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肺再生与慢性肺病报告或讨论可复核的学术证据。", "summary": "该节点将肺再生与慢性肺病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1107" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肺再生、慢性肺病与呼吸系统重建", "notes": "第 203 轮补录：肺再生与慢性肺病；待本地复核。；日期补齐：Crossref 2024-08-23 (published-print, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-432", "title": "《Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosis》论文发表", "date_start": "2023-05-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肺再生与慢性肺病报告或讨论可复核的学术证据。", "summary": "该节点将肺再生与慢性肺病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1108" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肺再生、慢性肺病与呼吸系统重建", "notes": "第 203 轮补录：肺再生与慢性肺病；待本地复核。；日期补齐：Crossref 2023-05-11 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-433", "title": "《Ziritaxestat and Lung Function in Idiopathic Pulmonary Fibrosis》论文发表", "date_start": "2023-09-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肺再生与慢性肺病报告或讨论可复核的学术证据。", "summary": "该节点将肺再生与慢性肺病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1109" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肺再生、慢性肺病与呼吸系统重建", "notes": "第 203 轮补录：肺再生与慢性肺病；待本地复核。；日期补齐：Crossref 2023-09-12 (published-print, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-434", "title": "《Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration》论文发表", "date_start": "2023-05-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肺再生与慢性肺病报告或讨论可复核的学术证据。", "summary": "该节点将肺再生与慢性肺病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1110" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肺再生、慢性肺病与呼吸系统重建", "notes": "第 203 轮补录：肺再生与慢性肺病；待本地复核。；日期补齐：Crossref 2023-05-26 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-435", "title": "《Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics》论文发表", "date_start": "2025-02-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肝脏再生与肝病逆转报告或讨论可复核的学术证据。", "summary": "该节点将肝脏再生与肝病逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1111" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肝脏再生、肝病逆转与代谢器官重建", "notes": "第 204 轮补录：肝脏再生与肝病逆转；待本地复核。；日期补齐：Crossref 2025-02-08 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-436", "title": "《Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice》论文发表", "date_start": "2024-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肝脏再生与肝病逆转报告或讨论可复核的学术证据。", "summary": "该节点将肝脏再生与肝病逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1112" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肝脏再生、肝病逆转与代谢器官重建", "notes": "第 204 轮补录：肝脏再生与肝病逆转；待本地复核。；日期补齐：Crossref 2024-03 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-437", "title": "《Human hepatocyte transplantation for liver disease: current status and future perspectives》论文发表", "date_start": "2017-12-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肝脏再生与肝病逆转报告或讨论可复核的学术证据。", "summary": "该节点将肝脏再生与肝病逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1113" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肝脏再生、肝病逆转与代谢器官重建", "notes": "第 204 轮补录：肝脏再生与肝病逆转；待本地复核。；日期补齐：Crossref 2017-12-06 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-438", "title": "《Liver regeneration: from myth to mechanism》论文发表", "date_start": "2004-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肝脏再生与肝病逆转报告或讨论可复核的学术证据。", "summary": "该节点将肝脏再生与肝病逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1114" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肝脏再生、肝病逆转与代谢器官重建", "notes": "第 204 轮补录：肝脏再生与肝病逆转；待本地复核。；日期补齐：Crossref 2004-10 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-439", "title": "《Clinical Implications of Advances in the Basic Science of Liver Repair and Regeneration》论文发表", "date_start": "2009-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肝脏再生与肝病逆转报告或讨论可复核的学术证据。", "summary": "该节点将肝脏再生与肝病逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1115" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肝脏再生、肝病逆转与代谢器官重建", "notes": "第 204 轮补录：肝脏再生与肝病逆转；待本地复核。；日期补齐：Crossref 2009-09 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-440", "title": "《ENPP1 blockade with a humanized monoclonal antibody enhances renal repair after acute kidney injury》论文发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肾脏再生与透析替代报告或讨论可复核的学术证据。", "summary": "该节点将肾脏再生与透析替代的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1116" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏再生、透析替代与排泄器官重建", "notes": "第 205 轮补录：肾脏再生与透析替代；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-441", "title": "《3D Bioprinted Renal Constructs Using Kidney‐Specific ECM Bioink System on Kidney Regeneration》论文发表", "date_start": "2025-06-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肾脏再生与透析替代报告或讨论可复核的学术证据。", "summary": "该节点将肾脏再生与透析替代的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1117" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏再生、透析替代与排泄器官重建", "notes": "第 205 轮补录：肾脏再生与透析替代；待本地复核。；日期补齐：Crossref 2025-06-26 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-442", "title": "《Collagen V regulates renal function after kidney injury and can be pharmacologically targeted to enhance kidney repair in mice》论文发表", "date_start": "2025-04-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肾脏再生与透析替代报告或讨论可复核的学术证据。", "summary": "该节点将肾脏再生与透析替代的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1118" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏再生、透析替代与排泄器官重建", "notes": "第 205 轮补录：肾脏再生与透析替代；待本地复核。；日期补齐：Crossref 2025-04-09 (published-print, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-443", "title": "《Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration》论文发表", "date_start": "2023-11-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肾脏再生与透析替代报告或讨论可复核的学术证据。", "summary": "该节点将肾脏再生与透析替代的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1119" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏再生、透析替代与排泄器官重建", "notes": "第 205 轮补录：肾脏再生与透析替代；待本地复核。；日期补齐：Crossref 2023-11-07 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-444", "title": "《Kidney Regeneration: Lessons from Development》论文发表", "date_start": "2015-01-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肾脏再生与透析替代报告或讨论可复核的学术证据。", "summary": "该节点将肾脏再生与透析替代的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1120" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏再生、透析替代与排泄器官重建", "notes": "第 205 轮补录：肾脏再生与透析替代；待本地复核。；日期补齐：Crossref 2015-01-31 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-445", "title": "《Islet organoids: a new hope for islet transplantation in diabetes》论文发表", "date_start": "2025-01-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胰岛细胞移植与糖尿病逆转报告或讨论可复核的学术证据。", "summary": "该节点将胰岛细胞移植与糖尿病逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1121" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胰岛细胞、糖尿病逆转与内分泌重建", "notes": "第 206 轮补录：胰岛细胞移植与糖尿病逆转；待本地复核。；日期补齐：Crossref 2025-01-21 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-446", "title": "《Revolutionizing islet transplantation with a preconditioning boost for beta cell survival》论文发表", "date_start": "2025-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胰岛细胞移植与糖尿病逆转报告或讨论可复核的学术证据。", "summary": "该节点将胰岛细胞移植与糖尿病逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1122" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胰岛细胞、糖尿病逆转与内分泌重建", "notes": "第 206 轮补录：胰岛细胞移植与糖尿病逆转；待本地复核。；日期补齐：Crossref 2025-08 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-447", "title": "《TRPC3 Regulates Islet Beta‐Cell Insulin Secretion》论文发表", "date_start": "2023-01-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胰岛细胞移植与糖尿病逆转报告或讨论可复核的学术证据。", "summary": "该节点将胰岛细胞移植与糖尿病逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1123" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胰岛细胞、糖尿病逆转与内分泌重建", "notes": "第 206 轮补录：胰岛细胞移植与糖尿病逆转；待本地复核。；日期补齐：Crossref 2023-01-15 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-448", "title": "《Islet transplantation: Current status and future directions》论文发表", "date_start": "2005-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胰岛细胞移植与糖尿病逆转报告或讨论可复核的学术证据。", "summary": "该节点将胰岛细胞移植与糖尿病逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1124" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胰岛细胞、糖尿病逆转与内分泌重建", "notes": "第 206 轮补录：胰岛细胞移植与糖尿病逆转；待本地复核。；日期补齐：Crossref 2005-07 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-449", "title": "《Warm ischemia time influences human islet cell isolation yield when assessed as beta cell number but not as islet equivalent number》论文发表", "date_start": "2021-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胰岛细胞移植与糖尿病逆转报告或讨论可复核的学术证据。", "summary": "该节点将胰岛细胞移植与糖尿病逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1125" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胰岛细胞、糖尿病逆转与内分泌重建", "notes": "第 206 轮补录：胰岛细胞移植与糖尿病逆转；待本地复核。；日期补齐：Crossref 2021-11 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-450", "title": "《NG2 glia reprogramming induces robust axonal regeneration after spinal cord injury》论文发表", "date_start": "2024-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕脊髓损伤修复与神经再生报告或讨论可复核的学术证据。", "summary": "该节点将脊髓损伤修复与神经再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1126" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脊髓损伤、神经再生与运动功能恢复", "notes": "第 207 轮补录：脊髓损伤修复与神经再生；待本地复核。；日期补齐：Crossref 2024-02 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-451", "title": "《Regulation of axonal regeneration after mammalian spinal cord injury》论文发表", "date_start": "2023-01-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕脊髓损伤修复与神经再生报告或讨论可复核的学术证据。", "summary": "该节点将脊髓损伤修复与神经再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1127" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脊髓损伤、神经再生与运动功能恢复", "notes": "第 207 轮补录：脊髓损伤修复与神经再生；待本地复核。；日期补齐：Crossref 2023-01-05 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-452", "title": "《Chondroitinase ABC promotes functional recovery after spinal cord injury》论文发表", "date_start": "2002-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕脊髓损伤修复与神经再生报告或讨论可复核的学术证据。", "summary": "该节点将脊髓损伤修复与神经再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1128" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脊髓损伤、神经再生与运动功能恢复", "notes": "第 207 轮补录：脊髓损伤修复与神经再生；待本地复核。；日期补齐：Crossref 2002-04 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-453", "title": "《Summary Statement: Repair of the Injured Spinal Cord》论文发表", "date_start": "2001-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕脊髓损伤修复与神经再生报告或讨论可复核的学术证据。", "summary": "该节点将脊髓损伤修复与神经再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1129" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脊髓损伤、神经再生与运动功能恢复", "notes": "第 207 轮补录：脊髓损伤修复与神经再生；待本地复核。；日期补齐：Crossref 2001-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-454", "title": "《The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury》论文发表", "date_start": "2024-07-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕脊髓损伤修复与神经再生报告或讨论可复核的学术证据。", "summary": "该节点将脊髓损伤修复与神经再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1130" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脊髓损伤、神经再生与运动功能恢复", "notes": "第 207 轮补录：脊髓损伤修复与神经再生；待本地复核。；日期补齐：Crossref 2024-07-08 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-455", "title": "《3’UTR regulation of axon translation and optic nerve regeneration》论文发表", "date_start": "2026-05-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕周围神经再生报告或讨论可复核的学术证据。", "summary": "该节点将周围神经再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1131" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "周围神经、轴突再生与感觉运动修复", "notes": "第 208 轮补录：周围神经再生；待本地复核。；日期补齐：Crossref 2026-05-29 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-456", "title": "《GFRα1 Promotes Axon Regeneration after Peripheral Nerve Injury by Functioning as a Ligand》论文发表", "date_start": "2024-12-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕周围神经再生报告或讨论可复核的学术证据。", "summary": "该节点将周围神经再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1132" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "周围神经、轴突再生与感觉运动修复", "notes": "第 208 轮补录：周围神经再生；待本地复核。；日期补齐：Crossref 2024-12-04 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-457", "title": "《In Vitro Models for Peripheral Nerve Regeneration》论文发表", "date_start": "2024-09-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕周围神经再生报告或讨论可复核的学术证据。", "summary": "该节点将周围神经再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1133" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "周围神经、轴突再生与感觉运动修复", "notes": "第 208 轮补录：周围神经再生；待本地复核。；日期补齐：Crossref 2024-09-26 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-458", "title": "《Scaffold design considerations for peripheral nerve regeneration》论文发表", "date_start": "2024-07-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕周围神经再生报告或讨论可复核的学术证据。", "summary": "该节点将周围神经再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1134" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "周围神经、轴突再生与感觉运动修复", "notes": "第 208 轮补录：周围神经再生；待本地复核。；日期补齐：Crossref 2024-07-23 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-459", "title": "《Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury》论文发表", "date_start": "2022-01-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕周围神经再生报告或讨论可复核的学术证据。", "summary": "该节点将周围神经再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1135" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "周围神经、轴突再生与感觉运动修复", "notes": "第 208 轮补录：周围神经再生；待本地复核。；日期补齐：Crossref 2022-01-28 (published-online, day, v3)", "created_at": "2026-08-07T05:03:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-460", "title": "《Functional Hydrogel Interfaces for Cartilage and Bone Regeneration》论文发表", "date_start": "2025-01-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕软骨与骨再生报告或讨论可复核的学术证据。", "summary": "该节点将软骨与骨再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1136" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "软骨、骨再生与骨骼肌肉重建", "notes": "第 209 轮补录：软骨与骨再生；待本地复核。；日期补齐：Crossref 2025-01-10 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-461", "title": "《Bone Tissue Engineering: State of the Art and Future Trends》论文发表", "date_start": "2004-08-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕软骨与骨再生报告或讨论可复核的学术证据。", "summary": "该节点将软骨与骨再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1137" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "软骨、骨再生与骨骼肌肉重建", "notes": "第 209 轮补录：软骨与骨再生；待本地复核。；日期补齐：Crossref 2004-08-03 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-462", "title": "《Advances in graphene-based 2D materials for tendon, nerve, bone/cartilage regeneration and biomedicine》论文发表", "date_start": "2024-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕软骨与骨再生报告或讨论可复核的学术证据。", "summary": "该节点将软骨与骨再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1138" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "软骨、骨再生与骨骼肌肉重建", "notes": "第 209 轮补录：软骨与骨再生；待本地复核。；日期补齐：Crossref 2024-07 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-463", "title": "《Unlike Bone, Cartilage Regeneration Remains Elusive》论文发表", "date_start": "2012-11-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕软骨与骨再生报告或讨论可复核的学术证据。", "summary": "该节点将软骨与骨再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1139" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "软骨、骨再生与骨骼肌肉重建", "notes": "第 209 轮补录：软骨与骨再生；待本地复核。；日期补齐：Crossref 2012-11-16 (published-print, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-464", "title": "《Gene therapy for repair and regeneration of bone and cartilage》论文发表", "date_start": "2018-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕软骨与骨再生报告或讨论可复核的学术证据。", "summary": "该节点将软骨与骨再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1140" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "软骨、骨再生与骨骼肌肉重建", "notes": "第 209 轮补录：软骨与骨再生；待本地复核。；日期补齐：Crossref 2018-06 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-465", "title": "《Promoting Treg Polarization‐Mediated Anti‐Scar and Appendage Regeneration in Wound Healing》论文发表", "date_start": "2026-02-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕皮肤再生与无瘢痕愈合报告或讨论可复核的学术证据。", "summary": "该节点将皮肤再生与无瘢痕愈合的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1141" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "皮肤再生、无瘢痕愈合与边界组织重建", "notes": "第 210 轮补录：皮肤再生与无瘢痕愈合；待本地复核。；日期补齐：Crossref 2026-02-24 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-466", "title": "《Sprayable Nanocomposites Hydrogel for Wound Healing and Skin Regeneration》论文发表", "date_start": "2024-10-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕皮肤再生与无瘢痕愈合报告或讨论可复核的学术证据。", "summary": "该节点将皮肤再生与无瘢痕愈合的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1142" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "皮肤再生、无瘢痕愈合与边界组织重建", "notes": "第 210 轮补录：皮肤再生与无瘢痕愈合；待本地复核。；日期补齐：Crossref 2024-10-14 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-467", "title": "《Wound healing in oral mucosa results in reduced scar formation as compared with skin: Evidence from the red Duroc pig model and humans》论文发表", "date_start": "2009-09-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕皮肤再生与无瘢痕愈合报告或讨论可复核的学术证据。", "summary": "该节点将皮肤再生与无瘢痕愈合的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1143" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "皮肤再生、无瘢痕愈合与边界组织重建", "notes": "第 210 轮补录：皮肤再生与无瘢痕愈合；待本地复核。；日期补齐：Crossref 2009-09-10 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-468", "title": "《Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation》论文发表", "date_start": "2017-04-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕皮肤再生与无瘢痕愈合报告或讨论可复核的学术证据。", "summary": "该节点将皮肤再生与无瘢痕愈合的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1144" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "皮肤再生、无瘢痕愈合与边界组织重建", "notes": "第 210 轮补录：皮肤再生与无瘢痕愈合；待本地复核。；日期补齐：Crossref 2017-04-27 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-469", "title": "《Wound Healing--Aiming for Perfect Skin Regeneration》论文发表", "date_start": "1997-04-04", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕皮肤再生与无瘢痕愈合报告或讨论可复核的学术证据。", "summary": "该节点将皮肤再生与无瘢痕愈合的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1145" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "皮肤再生、无瘢痕愈合与边界组织重建", "notes": "第 210 轮补录：皮肤再生与无瘢痕愈合；待本地复核。；日期补齐：Crossref 1997-04-04 (published-print, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-470", "title": "《Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕毛囊与感觉器官再生报告或讨论可复核的学术证据。", "summary": "该节点将毛囊与感觉器官再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1146" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "毛囊、感觉器官再生与表皮附属结构重建", "notes": "第 211 轮补录：毛囊与感觉器官再生；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-471", "title": "《MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regeneration》论文发表", "date_start": "2025-03-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕毛囊与感觉器官再生报告或讨论可复核的学术证据。", "summary": "该节点将毛囊与感觉器官再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1147" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "毛囊、感觉器官再生与表皮附属结构重建", "notes": "第 211 轮补录：毛囊与感觉器官再生；待本地复核。；日期补齐：Crossref 2025-03-22 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-472", "title": "《TLR2 regulates hair follicle cycle and regeneration via BMP signaling》论文发表", "date_start": "2024-03-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕毛囊与感觉器官再生报告或讨论可复核的学术证据。", "summary": "该节点将毛囊与感觉器官再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1148" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "毛囊、感觉器官再生与表皮附属结构重建", "notes": "第 211 轮补录：毛囊与感觉器官再生；待本地复核。；日期补齐：Crossref 2024-03-14 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-473", "title": "《Nanotechnology-based techniques for hair follicle regeneration》论文发表", "date_start": "2023-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕毛囊与感觉器官再生报告或讨论可复核的学术证据。", "summary": "该节点将毛囊与感觉器官再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1149" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "毛囊、感觉器官再生与表皮附属结构重建", "notes": "第 211 轮补录：毛囊与感觉器官再生；待本地复核。；日期补齐：Crossref 2023-11 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-474", "title": "《Immune modulation of hair follicle regeneration》论文发表", "date_start": "2020-05-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕毛囊与感觉器官再生报告或讨论可复核的学术证据。", "summary": "该节点将毛囊与感觉器官再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1150" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "毛囊、感觉器官再生与表皮附属结构重建", "notes": "第 211 轮补录：毛囊与感觉器官再生；待本地复核。；日期补齐：Crossref 2020-05-11 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-475", "title": "《Nanotherapy for Neural Retinal Regeneration》论文发表", "date_start": "2025-01-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕视网膜再生与视力恢复报告或讨论可复核的学术证据。", "summary": "该节点将视网膜再生与视力恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1151" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "视网膜、视觉通路与感官功能恢复", "notes": "第 212 轮补录：视网膜再生与视力恢复；待本地复核。；日期补齐：Crossref 2025-01-14 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-476", "title": "《KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis》论文发表", "date_start": "2024-04-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕视网膜再生与视力恢复报告或讨论可复核的学术证据。", "summary": "该节点将视网膜再生与视力恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1152" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "视网膜、视觉通路与感官功能恢复", "notes": "第 212 轮补录：视网膜再生与视力恢复；待本地复核。；日期补齐：Crossref 2024-04-26 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-477", "title": "《Müller glia are a potential source of neural regeneration in the postnatal chicken retina》论文发表", "date_start": "2001-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕视网膜再生与视力恢复报告或讨论可复核的学术证据。", "summary": "该节点将视网膜再生与视力恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1153" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "视网膜、视觉通路与感官功能恢复", "notes": "第 212 轮补录：视网膜再生与视力恢复；待本地复核。；日期补齐：Crossref 2001-03 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-478", "title": "《Retinal Regeneration in Mammals?》论文发表", "date_start": "2000-03-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕视网膜再生与视力恢复报告或讨论可复核的学术证据。", "summary": "该节点将视网膜再生与视力恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1154" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "视网膜、视觉通路与感官功能恢复", "notes": "第 212 轮补录：视网膜再生与视力恢复；待本地复核。；日期补齐：Crossref 2000-03-17 (published-print, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-479", "title": "《Invited Session II: Retinal remodeling and regeneration: Insights into retinal cell replacement: Optimising photoreceptor and RPE transplantation》论文发表", "date_start": "2023-12-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕视网膜再生与视力恢复报告或讨论可复核的学术证据。", "summary": "该节点将视网膜再生与视力恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1155" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "视网膜、视觉通路与感官功能恢复", "notes": "第 212 轮补录：视网膜再生与视力恢复；待本地复核。；日期补齐：Crossref 2023-12-01 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-480", "title": "《Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ》论文发表", "date_start": "2024-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕内耳毛细胞再生与听力恢复报告或讨论可复核的学术证据。", "summary": "该节点将内耳毛细胞再生与听力恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1156" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内耳毛细胞、听力恢复与感觉神经修复", "notes": "第 213 轮补录：内耳毛细胞再生与听力恢复；待本地复核。；日期补齐：Crossref 2024-03 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-481", "title": "《The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration》论文发表", "date_start": "2025-09-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕内耳毛细胞再生与听力恢复报告或讨论可复核的学术证据。", "summary": "该节点将内耳毛细胞再生与听力恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1157" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内耳毛细胞、听力恢复与感觉神经修复", "notes": "第 213 轮补录：内耳毛细胞再生与听力恢复；待本地复核。；日期补齐：Crossref 2025-09-01 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-483", "title": "《Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma》论文发表", "date_start": "2013-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕内耳毛细胞再生与听力恢复报告或讨论可复核的学术证据。", "summary": "该节点将内耳毛细胞再生与听力恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1159" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内耳毛细胞、听力恢复与感觉神经修复", "notes": "第 213 轮补录：内耳毛细胞再生与听力恢复；待本地复核。；日期补齐：Crossref 2013-04 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-484", "title": "《Recent advances in cochlear hair cell regeneration—A promising opportunity for the treatment of age-related hearing loss》论文发表", "date_start": "2017-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕内耳毛细胞再生与听力恢复报告或讨论可复核的学术证据。", "summary": "该节点将内耳毛细胞再生与听力恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1160" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内耳毛细胞、听力恢复与感觉神经修复", "notes": "第 213 轮补录：内耳毛细胞再生与听力恢复；待本地复核。；日期补齐：Crossref 2017-07 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-485", "title": "《Thymus regeneration therapies: entering a new era》论文发表", "date_start": "2026-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胸腺再生与免疫重建报告或讨论可复核的学术证据。", "summary": "该节点将胸腺再生与免疫重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1161" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胸腺再生、免疫重建与免疫系统维护", "notes": "第 214 轮补录：胸腺再生与免疫重建；待本地复核。；日期补齐：Crossref 2026-04 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-486", "title": "《The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration》论文发表", "date_start": "2023-11-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胸腺再生与免疫重建报告或讨论可复核的学术证据。", "summary": "该节点将胸腺再生与免疫重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1162" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胸腺再生、免疫重建与免疫系统维护", "notes": "第 214 轮补录：胸腺再生与免疫重建；待本地复核。；日期补齐：Crossref 2023-11-08 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-487", "title": "《Immune Reconstitution in the Aging Host: Opportunities for Mechanism-Based Therapy in Allogeneic Hematopoietic Cell Transplantation》论文发表", "date_start": "2021-04-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胸腺再生与免疫重建报告或讨论可复核的学术证据。", "summary": "该节点将胸腺再生与免疫重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1163" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胸腺再生、免疫重建与免疫系统维护", "notes": "第 214 轮补录：胸腺再生与免疫重建；待本地复核。；日期补齐：Crossref 2021-04-19 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-488", "title": "《Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection》论文发表", "date_start": "2021-05-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胸腺再生与免疫重建报告或讨论可复核的学术证据。", "summary": "该节点将胸腺再生与免疫重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1164" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胸腺再生、免疫重建与免疫系统维护", "notes": "第 214 轮补录：胸腺再生与免疫重建；待本地复核。；日期补齐：Crossref 2021-05-26 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-489", "title": "《Thymus Degeneration and Regeneration》论文发表", "date_start": "2021-09-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胸腺再生与免疫重建报告或讨论可复核的学术证据。", "summary": "该节点将胸腺再生与免疫重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1165" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胸腺再生、免疫重建与免疫系统维护", "notes": "第 214 轮补录：胸腺再生与免疫重建；待本地复核。；日期补齐：Crossref 2021-09-01 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-490", "title": "《Advances in second hematopoietic stem cell transplantation》论文发表", "date_start": "2024-07-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕造血干细胞移植与血液重建报告或讨论可复核的学术证据。", "summary": "该节点将造血干细胞移植与血液重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1166" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "造血干细胞、血液重建与再生医学", "notes": "第 215 轮补录：造血干细胞移植与血液重建；待本地复核。；日期补齐：Crossref 2024-07-09 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-491", "title": "《Growing and aging of hematopoietic stem cells》论文发表", "date_start": "2021-06-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕造血干细胞移植与血液重建报告或讨论可复核的学术证据。", "summary": "该节点将造血干细胞移植与血液重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1167" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "造血干细胞、血液重建与再生医学", "notes": "第 215 轮补录：造血干细胞移植与血液重建；待本地复核。；日期补齐：Crossref 2021-06-26 (published-print, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-492", "title": "《Hematopoiesis: An Evolving Paradigm for Stem Cell Biology》论文发表", "date_start": "2008-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕造血干细胞移植与血液重建报告或讨论可复核的学术证据。", "summary": "该节点将造血干细胞移植与血液重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1168" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "造血干细胞、血液重建与再生医学", "notes": "第 215 轮补录：造血干细胞移植与血液重建；待本地复核。；日期补齐：Crossref 2008-02 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-493", "title": "《Hematopoietic stem cell aging: Mechanism and consequence》论文发表", "date_start": "2007-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕造血干细胞移植与血液重建报告或讨论可复核的学术证据。", "summary": "该节点将造血干细胞移植与血液重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1169" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "造血干细胞、血液重建与再生医学", "notes": "第 215 轮补录：造血干细胞移植与血液重建；待本地复核。；日期补齐：Crossref 2007-05 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-494", "title": "《Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration》论文发表", "date_start": "2021-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕造血干细胞移植与血液重建报告或讨论可复核的学术证据。", "summary": "该节点将造血干细胞移植与血液重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1170" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "造血干细胞、血液重建与再生医学", "notes": "第 215 轮补录：造血干细胞移植与血液重建；待本地复核。；日期补齐：Crossref 2021-11 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-495", "title": "《Advances and clinical challenges of mesenchymal stem cell therapy》论文发表", "date_start": "2024-07-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕间充质干细胞治疗报告或讨论可复核的学术证据。", "summary": "该节点将间充质干细胞治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1171" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "间充质干细胞、组织修复与免疫调节", "notes": "第 216 轮补录：间充质干细胞治疗；待本地复核。；日期补齐：Crossref 2024-07-19 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-496", "title": "《Immunomodulatory role of mesenchymal stem cell therapy in liver fibrosis》论文发表", "date_start": "2023-01-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕间充质干细胞治疗报告或讨论可复核的学术证据。", "summary": "该节点将间充质干细胞治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1172" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "间充质干细胞、组织修复与免疫调节", "notes": "第 216 轮补录：间充质干细胞治疗；待本地复核。；日期补齐：Crossref 2023-01-04 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-497", "title": "《Mesenchymal Stem Cells-based Cell-free Therapy Targeting Neuroinflammation》论文发表", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕间充质干细胞治疗报告或讨论可复核的学术证据。", "summary": "该节点将间充质干细胞治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1173" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "间充质干细胞、组织修复与免疫调节", "notes": "第 216 轮补录：间充质干细胞治疗；待本地复核。；日期补齐：Crossref 2023 (published-print, year, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-498", "title": "《Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing》论文发表", "date_start": "2010-06-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕间充质干细胞治疗报告或讨论可复核的学术证据。", "summary": "该节点将间充质干细胞治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1174" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "间充质干细胞、组织修复与免疫调节", "notes": "第 216 轮补录：间充质干细胞治疗；待本地复核。；日期补齐：Crossref 2010-06-01 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-499", "title": "《Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy》论文发表", "date_start": "2021-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕间充质干细胞治疗报告或讨论可复核的学术证据。", "summary": "该节点将间充质干细胞治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1175" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "间充质干细胞、组织修复与免疫调节", "notes": "第 216 轮补录：间充质干细胞治疗；待本地复核。；日期补齐：Crossref 2021-10 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-500", "title": "《Human organoid systems in modeling reproductive tissue development, function, and disease》论文发表", "date_start": "2023-04-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕类器官疾病模型报告或讨论可复核的学术证据。", "summary": "该节点将类器官疾病模型的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1176" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "类器官、疾病建模与器官生理重建", "notes": "第 217 轮补录：类器官疾病模型；待本地复核。；日期补齐：Crossref 2023-04-29 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-501", "title": "《Human organoids: model systems for human biology and medicine》论文发表", "date_start": "2020-07-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕类器官疾病模型报告或讨论可复核的学术证据。", "summary": "该节点将类器官疾病模型的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1177" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "类器官、疾病建模与器官生理重建", "notes": "第 217 轮补录：类器官疾病模型；待本地复核。；日期补齐：Crossref 2020-07-07 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-502", "title": "《Organogenesis in a dish: Modeling development and disease using organoid technologies》论文发表", "date_start": "2014-07-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕类器官疾病模型报告或讨论可复核的学术证据。", "summary": "该节点将类器官疾病模型的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1178" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "类器官、疾病建模与器官生理重建", "notes": "第 217 轮补录：类器官疾病模型；待本地复核。；日期补齐：Crossref 2014-07-18 (published-print, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-503", "title": "《A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery》论文发表", "date_start": "2022-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕类器官疾病模型报告或讨论可复核的学术证据。", "summary": "该节点将类器官疾病模型的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1179" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "类器官、疾病建模与器官生理重建", "notes": "第 217 轮补录：类器官疾病模型；待本地复核。；日期补齐：Crossref 2022-07 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-504", "title": "《NEUBOrg: Artificially Induced Pluripotent Stem Cell-Derived Brain Organoid to Model and Study Genetics of Alzheimer’s Disease Progression》论文发表", "date_start": "2021-02-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕类器官疾病模型报告或讨论可复核的学术证据。", "summary": "该节点将类器官疾病模型的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1180" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "类器官、疾病建模与器官生理重建", "notes": "第 217 轮补录：类器官疾病模型；待本地复核。；日期补齐：Crossref 2021-02-23 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-505", "title": "《3D bioprinting of tissues and organs》论文发表", "date_start": "2014-08-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕3D生物打印器官报告或讨论可复核的学术证据。", "summary": "该节点将3D生物打印器官的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1181" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "3D生物打印、器官制造与结构重建", "notes": "第 218 轮补录：3D生物打印器官；待本地复核。；日期补齐：Crossref 2014-08-05 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-506", "title": "《3D Bioprinting for Organ Regeneration》论文发表", "date_start": "2016-12-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕3D生物打印器官报告或讨论可复核的学术证据。", "summary": "该节点将3D生物打印器官的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1182" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "3D生物打印、器官制造与结构重建", "notes": "第 218 轮补录：3D生物打印器官；待本地复核。；日期补齐：Crossref 2016-12-20 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-507", "title": "《Progress in 3D bioprinting technology for tissue/organ regenerative engineering》论文发表", "date_start": "2020-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕3D生物打印器官报告或讨论可复核的学术证据。", "summary": "该节点将3D生物打印器官的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1183" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "3D生物打印、器官制造与结构重建", "notes": "第 218 轮补录：3D生物打印器官；待本地复核。；日期补齐：Crossref 2020-01 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-508", "title": "《Tissue and Organ 3D Bioprinting》论文发表", "date_start": "2018-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕3D生物打印器官报告或讨论可复核的学术证据。", "summary": "该节点将3D生物打印器官的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1184" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "3D生物打印、器官制造与结构重建", "notes": "第 218 轮补录：3D生物打印器官；待本地复核。；日期补齐：Crossref 2018-08 (published-print, month, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-509", "title": "《Current Developments in 3D Bioprinting for Tissue and Organ Regeneration–A Review》论文发表", "date_start": "2020-10-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕3D生物打印器官报告或讨论可复核的学术证据。", "summary": "该节点将3D生物打印器官的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1185" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "3D生物打印、器官制造与结构重建", "notes": "第 218 轮补录：3D生物打印器官；待本地复核。；日期补齐：Crossref 2020-10-30 (published-online, day, v3)", "created_at": "2026-08-07T05:03:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-510", "title": "《Democratizing Organ‐On‐Chip Technologies With a Modular, Reusable, and Perfusion‐Ready Microphysiological System》论文发表", "date_start": "2025-09-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官芯片药物评价报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片药物评价的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1186" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、微生理系统与药物评价", "notes": "第 219 轮补录：器官芯片药物评价；待本地复核。；日期补齐：Crossref 2025-09-10 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-511", "title": "《Vascular microphysiological system as an organ preservation testbed》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官芯片药物评价报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片药物评价的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1187" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、微生理系统与药物评价", "notes": "第 219 轮补录：器官芯片药物评价；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-512", "title": "《Reconstituting Organ-Level Lung Functions on a Chip》论文发表", "date_start": "2010-06-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官芯片药物评价报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片药物评价的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1188" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、微生理系统与药物评价", "notes": "第 219 轮补录：器官芯片药物评价；待本地复核。；日期补齐：Crossref 2010-06-25 (published-print, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-514", "title": "《Microfluidic organs-on-chips》论文发表", "date_start": "2014-08-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官芯片药物评价报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片药物评价的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1190" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、微生理系统与药物评价", "notes": "第 219 轮补录：器官芯片药物评价；待本地复核。；日期补齐：Crossref 2014-08-05 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-515", "title": "《Genetically modified pig liver keeps man alive until human organ transplant》论文发表", "date_start": "2026-03-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕异种器官移植临床报告或讨论可复核的学术证据。", "summary": "该节点将异种器官移植临床的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1191" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、跨物种器官替代与临床转化", "notes": "第 220 轮补录：异种器官移植临床；待本地复核。；日期补齐：Crossref 2026-03-06 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-516", "title": "《Clinical Kidney Xenotransplantation—Why Do We Not Transplant Both Pig Kidneys Into the Recipient?》论文发表", "date_start": "2025-11-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕异种器官移植临床报告或讨论可复核的学术证据。", "summary": "该节点将异种器官移植临床的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1192" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、跨物种器官替代与临床转化", "notes": "第 220 轮补录：异种器官移植临床；待本地复核。；日期补齐：Crossref 2025-11-20 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-517", "title": "《Endothelial Injury and Fibrogenesis Drives Post-Transplant Response After Pig-to-Human Heart Xenotransplantation》论文发表", "date_start": "2025-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕异种器官移植临床报告或讨论可复核的学术证据。", "summary": "该节点将异种器官移植临床的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1193" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、跨物种器官替代与临床转化", "notes": "第 220 轮补录：异种器官移植临床；待本地复核。；日期补齐：Crossref 2025-08 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-518", "title": "《How Much Will a Pig Organ Transplant Cost? A Preliminary Estimate of the Cost of Xenotransplantation Versus Allotransplantation in the USA》论文发表", "date_start": "2025-02-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕异种器官移植临床报告或讨论可复核的学术证据。", "summary": "该节点将异种器官移植临床的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1194" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、跨物种器官替代与临床转化", "notes": "第 220 轮补录：异种器官移植临床；待本地复核。；日期补齐：Crossref 2025-02-24 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-519", "title": "《Two US surgical teams transplant functional pig kidneys into humans in xenotransplantation success》论文发表", "date_start": "2023-09-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕异种器官移植临床报告或讨论可复核的学术证据。", "summary": "该节点将异种器官移植临床的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1195" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "异种移植、跨物种器官替代与临床转化", "notes": "第 220 轮补录：异种器官移植临床；待本地复核。；日期补齐：Crossref 2023-09-11 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-520", "title": "《Advancing Organ Preservation and Perfusion: Introducing the International Society of Organ Preservation and Perfusion Therapy (ISOPPT)》论文发表", "date_start": "2026-06-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕器官灌注保存与移植前修复报告或讨论可复核的学术证据。", "summary": "该节点将器官灌注保存与移植前修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1196" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官灌注、离体保存与移植前修复", "notes": "第 221 轮补录：器官灌注保存与移植前修复；待本地复核。；日期补齐：Crossref 2026-06-17 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-521", "title": "《Crash course: organ perfusion technologies - improving the physiology of transplant preservation and creating opportunities for organ cryopreservation?》论文发表", "date_start": "2018-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕器官灌注保存与移植前修复报告或讨论可复核的学术证据。", "summary": "该节点将器官灌注保存与移植前修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1197" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官灌注、离体保存与移植前修复", "notes": "第 221 轮补录：器官灌注保存与移植前修复；待本地复核。；日期补齐：Crossref 2018-04 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-522", "title": "《Endoplasmic and Vascular Surface Activation During Organ Preservation: Refining Upon the Benefits of Machine Perfusion》论文发表", "date_start": "2006-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕器官灌注保存与移植前修复报告或讨论可复核的学术证据。", "summary": "该节点将器官灌注保存与移植前修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1198" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官灌注、离体保存与移植前修复", "notes": "第 221 轮补录：器官灌注保存与移植前修复；待本地复核。；日期补齐：Crossref 2006-06 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-523", "title": "《14. Hypothermic machine perfusion for organ preservation》论文发表", "date_start": "2006-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕器官灌注保存与移植前修复报告或讨论可复核的学术证据。", "summary": "该节点将器官灌注保存与移植前修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1199" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官灌注、离体保存与移植前修复", "notes": "第 221 轮补录：器官灌注保存与移植前修复；待本地复核。；日期补齐：Crossref 2006-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-524", "title": "《Hypothermic perfusion preservation: The future of organ preservation revisited?》论文发表", "date_start": "2007-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕器官灌注保存与移植前修复报告或讨论可复核的学术证据。", "summary": "该节点将器官灌注保存与移植前修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1200" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官灌注、离体保存与移植前修复", "notes": "第 221 轮补录：器官灌注保存与移植前修复；待本地复核。；日期补齐：Crossref 2007-04 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-525", "title": "《Organ Cryopreservation by Vitrification: Challenges and Opportunities》论文发表", "date_start": "2021-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕深低温保存与玻璃化报告或讨论可复核的学术证据。", "summary": "该节点将深低温保存与玻璃化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1201" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "深低温保存、玻璃化与组织停滞", "notes": "第 222 轮补录：深低温保存与玻璃化；待本地复核。；日期补齐：Crossref 2021-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-526", "title": "《Vitrification as a prospect for cryopreservation of tissue-engineered constructs》论文发表", "date_start": "2007-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕深低温保存与玻璃化报告或讨论可复核的学术证据。", "summary": "该节点将深低温保存与玻璃化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1202" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "深低温保存、玻璃化与组织停滞", "notes": "第 222 轮补录：深低温保存与玻璃化；待本地复核。；日期补齐：Crossref 2007-03 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-527", "title": "《Ovarian tissue cryopreservation using vitrification and/orin vitroactivated technology》论文发表", "date_start": "2015-09-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕深低温保存与玻璃化报告或讨论可复核的学术证据。", "summary": "该节点将深低温保存与玻璃化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1203" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "深低温保存、玻璃化与组织停滞", "notes": "第 222 轮补录：深低温保存与玻璃化；待本地复核。；日期补齐：Crossref 2015-09-06 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-528", "title": "《Cryopreservation of porcine intact tibial plateau using vitrification》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕深低温保存与玻璃化报告或讨论可复核的学术证据。", "summary": "该节点将深低温保存与玻璃化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1204" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "深低温保存、玻璃化与组织停滞", "notes": "第 222 轮补录：深低温保存与玻璃化；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-529", "title": "《Cryopreservation of mesenchymal stromal cells spheroids by vitrification》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕深低温保存与玻璃化报告或讨论可复核的学术证据。", "summary": "该节点将深低温保存与玻璃化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1205" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "深低温保存、玻璃化与组织停滞", "notes": "第 222 轮补录：深低温保存与玻璃化；待本地复核。；日期补齐：Crossref 2023-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-530", "title": "《BIostasis: a transformative capability for human civilization》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕冷冻复苏与生物停滞报告或讨论可复核的学术证据。", "summary": "该节点将冷冻复苏与生物停滞的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1206" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "冷冻复苏、生物停滞与未来选择权", "notes": "第 223 轮补录：冷冻复苏与生物停滞；待本地复核。；日期补齐：Crossref 2023-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-531", "title": "《Cryonics Takes Another Big Step Toward the Mainstream》论文发表", "date_start": "2020-06-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕冷冻复苏与生物停滞报告或讨论可复核的学术证据。", "summary": "该节点将冷冻复苏与生物停滞的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1207" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "冷冻复苏、生物停滞与未来选择权", "notes": "第 223 轮补录：冷冻复苏与生物停滞；待本地复核。；日期补齐：Crossref 2020-06-16 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-532", "title": "《Brain Preservation and Cryonics Through the Lens of Moral Psychology》论文发表", "date_start": "2025-01-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕冷冻复苏与生物停滞报告或讨论可复核的学术证据。", "summary": "该节点将冷冻复苏与生物停滞的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1208" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "冷冻复苏、生物停滞与未来选择权", "notes": "第 223 轮补录：冷冻复苏与生物停滞；待本地复核。；日期补齐：Crossref 2025-01-31 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-533", "title": "《Biostasis: A Roadmap for Research in Preservation and Potential Revival of Humans》论文发表", "date_start": "2024-09-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕冷冻复苏与生物停滞报告或讨论可复核的学术证据。", "summary": "该节点将冷冻复苏与生物停滞的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1209" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "冷冻复苏、生物停滞与未来选择权", "notes": "第 223 轮补录：冷冻复苏与生物停滞；待本地复核。；日期补齐：Crossref 2024-09-21 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-534", "title": "《Frozen Bodies and Future Imaginaries: Assisted Dying, Cryonics, and a Good Death》论文发表", "date_start": "2020-11-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕冷冻复苏与生物停滞报告或讨论可复核的学术证据。", "summary": "该节点将冷冻复苏与生物停滞的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1210" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "冷冻复苏、生物停滞与未来选择权", "notes": "第 223 轮补录：冷冻复苏与生物停滞；待本地复核。；日期补齐：Crossref 2020-11-05 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-535", "title": "《Nanoparticle therapeutics: an emerging treatment modality for cancer》论文发表", "date_start": "2008-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米医学与靶向药物递送报告或讨论可复核的学术证据。", "summary": "该节点将纳米医学与靶向药物递送的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1211" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学、靶向递送与分子级修复", "notes": "第 224 轮补录：纳米医学与靶向药物递送；待本地复核。；日期补齐：Crossref 2008-09 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-536", "title": "《Drug delivery and nanoparticles: Applications and hazards》论文发表", "date_start": "2008-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米医学与靶向药物递送报告或讨论可复核的学术证据。", "summary": "该节点将纳米医学与靶向药物递送的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1212" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学、靶向递送与分子级修复", "notes": "第 224 轮补录：纳米医学与靶向药物递送；待本地复核。；日期补齐：Crossref 2008-06 (published-online, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-537", "title": "《Multifunctional nanoparticle–EpCAM aptamer bioconjugates: A paradigm for targeted drug delivery and imaging in cancer therapy》论文发表", "date_start": "2015-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米医学与靶向药物递送报告或讨论可复核的学术证据。", "summary": "该节点将纳米医学与靶向药物递送的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1213" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学、靶向递送与分子级修复", "notes": "第 224 轮补录：纳米医学与靶向药物递送；待本地复核。；日期补齐：Crossref 2015-02 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-538", "title": "《Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor》论文发表", "date_start": "2015-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米医学与靶向药物递送报告或讨论可复核的学术证据。", "summary": "该节点将纳米医学与靶向药物递送的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1214" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学、靶向递送与分子级修复", "notes": "第 224 轮补录：纳米医学与靶向药物递送；待本地复核。；日期补齐：Crossref 2015-12 (published-online, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-539", "title": "《Curcumin-guided nanotherapy: a lipid-based nanomedicine for targeted drug delivery in breast cancer therapy》论文发表", "date_start": "2015-07-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米医学与靶向药物递送报告或讨论可复核的学术证据。", "summary": "该节点将纳米医学与靶向药物递送的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1215" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米医学、靶向递送与分子级修复", "notes": "第 224 轮补录：纳米医学与靶向药物递送；待本地复核。；日期补齐：Crossref 2015-07-23 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-540", "title": "《A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads》论文发表", "date_start": "2012-02-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米机器人生物医学报告或讨论可复核的学术证据。", "summary": "该节点将纳米机器人生物医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1216" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米机器人、分子机器与体内诊断修复", "notes": "第 225 轮补录：纳米机器人生物医学；待本地复核。；日期补齐：Crossref 2012-02-17 (published-print, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-541", "title": "《A DNA Nanorobot Uprises against Cancer》论文发表", "date_start": "2018-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米机器人生物医学报告或讨论可复核的学术证据。", "summary": "该节点将纳米机器人生物医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1217" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米机器人、分子机器与体内诊断修复", "notes": "第 225 轮补录：纳米机器人生物医学；待本地复核。；日期补齐：Crossref 2018-07 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-542", "title": "《Design and Control of the Magnetically Actuated Micro/Nanorobot Swarm toward Biomedical Applications》论文发表", "date_start": "2024-03-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米机器人生物医学报告或讨论可复核的学术证据。", "summary": "该节点将纳米机器人生物医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1218" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米机器人、分子机器与体内诊断修复", "notes": "第 225 轮补录：纳米机器人生物医学；待本地复核。；日期补齐：Crossref 2024-03-08 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-543", "title": "《Synchronous Rotation-Based Knot Tying on Mini-Incisions Using Dual-Arm Nanorobot》论文发表", "date_start": "2025-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米机器人生物医学报告或讨论可复核的学术证据。", "summary": "该节点将纳米机器人生物医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1219" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米机器人、分子机器与体内诊断修复", "notes": "第 225 轮补录：纳米机器人生物医学；待本地复核。；日期补齐：Crossref 2025-06 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-544", "title": "《Nanorobot-Based Direct Implantation of Flexible Neural Electrode for BCI》论文发表", "date_start": "2024-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米机器人生物医学报告或讨论可复核的学术证据。", "summary": "该节点将纳米机器人生物医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1220" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "纳米机器人、分子机器与体内诊断修复", "notes": "第 225 轮补录：纳米机器人生物医学；待本地复核。；日期补齐：Crossref 2024-10 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-545", "title": "《DNA origami: a history and current perspective》论文发表", "date_start": "2010-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕分子机器与DNA纳米技术报告或讨论可复核的学术证据。", "summary": "该节点将分子机器与DNA纳米技术的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1221" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "DNA纳米技术、分子机器与可编程材料", "notes": "第 226 轮补录：分子机器与DNA纳米技术；待本地复核。；日期补齐：Crossref 2010-10 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-546", "title": "《Folding DNA to create nanoscale shapes and patterns》论文发表", "date_start": "2006-03-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕分子机器与DNA纳米技术报告或讨论可复核的学术证据。", "summary": "该节点将分子机器与DNA纳米技术的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1222" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "DNA纳米技术、分子机器与可编程材料", "notes": "第 226 轮补录：分子机器与DNA纳米技术；待本地复核。；日期补齐：Crossref 2006-03-16 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-547", "title": "《A DNA-fuelled molecular machine made of DNA》论文发表", "date_start": "2000-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕分子机器与DNA纳米技术报告或讨论可复核的学术证据。", "summary": "该节点将分子机器与DNA纳米技术的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1223" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "DNA纳米技术、分子机器与可编程材料", "notes": "第 226 轮补录：分子机器与DNA纳米技术；待本地复核。；日期补齐：Crossref 2000-08 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-548", "title": "《DNA Nanotechnology: From DNA Nanotechnology to Material Systems Engineering (Adv. Mater. 26/2019)》论文发表", "date_start": "2019-06-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕分子机器与DNA纳米技术报告或讨论可复核的学术证据。", "summary": "该节点将分子机器与DNA纳米技术的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1224" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "DNA纳米技术、分子机器与可编程材料", "notes": "第 226 轮补录：分子机器与DNA纳米技术；待本地复核。；日期补齐：Crossref 2019-06-24 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-549", "title": "《Designed DNA molecules: principles and applications of molecular nanotechnology》论文发表", "date_start": "2006-06-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕分子机器与DNA纳米技术报告或讨论可复核的学术证据。", "summary": "该节点将分子机器与DNA纳米技术的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1225" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "DNA纳米技术、分子机器与可编程材料", "notes": "第 226 轮补录：分子机器与DNA纳米技术；待本地复核。；日期补齐：Crossref 2006-06-13 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-550", "title": "《Integrating bioelectronics with cell-based synthetic biology》论文发表", "date_start": "2025-01-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕合成生物学与细胞编程报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学与细胞编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1226" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "合成生物学、细胞编程与生命系统重构", "notes": "第 227 轮补录：合成生物学与细胞编程；待本地复核。；日期补齐：Crossref 2025-01-07 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-551", "title": "《Programming of synthetic regulatory DNA for cell-type targeting in humans》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕合成生物学与细胞编程报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学与细胞编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1227" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "合成生物学、细胞编程与生命系统重构", "notes": "第 227 轮补录：合成生物学与细胞编程；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-552", "title": "《Synthetic Organisms Simplify Biology》论文发表", "date_start": "2019-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕合成生物学与细胞编程报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学与细胞编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1228" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "合成生物学、细胞编程与生命系统重构", "notes": "第 227 轮补录：合成生物学与细胞编程；待本地复核。；日期补齐：Crossref 2019-06 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-553", "title": "《A Synthetic Bacterial Cell-Cell Adhesion Toolbox for Programming Multicellular Morphologies and Patterns》论文发表", "date_start": "2018-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕合成生物学与细胞编程报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学与细胞编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1229" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "合成生物学、细胞编程与生命系统重构", "notes": "第 227 轮补录：合成生物学与细胞编程；待本地复核。；日期补齐：Crossref 2018-07 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-554", "title": "《Programming gene and engineered-cell therapies with synthetic biology》论文发表", "date_start": "2018-02-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕合成生物学与细胞编程报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学与细胞编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1230" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "合成生物学、细胞编程与生命系统重构", "notes": "第 227 轮补录：合成生物学与细胞编程；待本地复核。；日期补齐：Crossref 2018-02-09 (published-print, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-555", "title": "《Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins》论文发表", "date_start": "2025-08-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕基因编辑与表观基因组编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因编辑与表观基因组编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1231" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因编辑、表观基因组编辑与生命状态重写", "notes": "第 228 轮补录：基因编辑与表观基因组编辑；待本地复核。；日期补齐：Crossref 2025-08-26 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-556", "title": "《CRISPR technologies for genome, epigenome and transcriptome editing》论文发表", "date_start": "2024-02-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕基因编辑与表观基因组编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因编辑与表观基因组编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1232" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因编辑、表观基因组编辑与生命状态重写", "notes": "第 228 轮补录：基因编辑与表观基因组编辑；待本地复核。；日期补齐：Crossref 2024-02-02 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-557", "title": "《Epigenome editing technologies for discovery and medicine》论文发表", "date_start": "2024-07-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕基因编辑与表观基因组编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因编辑与表观基因组编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1233" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因编辑、表观基因组编辑与生命状态重写", "notes": "第 228 轮补录：基因编辑与表观基因组编辑；待本地复核。；日期补齐：Crossref 2024-07-29 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-558", "title": "《Promoter editing generates stable setpoints of gene expression》论文发表", "date_start": "2025-10-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕基因编辑与表观基因组编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因编辑与表观基因组编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1234" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因编辑、表观基因组编辑与生命状态重写", "notes": "第 228 轮补录：基因编辑与表观基因组编辑；待本地复核。；日期补齐：Crossref 2025-10-13 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-559", "title": "《Epigenome editing》论文发表", "date_start": "2015-05-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕基因编辑与表观基因组编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因编辑与表观基因组编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1235" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因编辑、表观基因组编辑与生命状态重写", "notes": "第 228 轮补录：基因编辑与表观基因组编辑；待本地复核。；日期补齐：Crossref 2015-05-28 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-560", "title": "《Therapeutic applications of mitochondrial transplantation》论文发表", "date_start": "2022-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体移植与能量医学报告治疗性线粒体移植的应用。", "summary": "该节点将治疗性线粒体移植纳入细胞供能与能量医学路径。", "sources": [ "SRC-1236" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体移植、能量医学与细胞供能修复", "notes": "第 229 轮补录：线粒体移植与能量医学；待本地复核。；日期补齐：Crossref 2022-04 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-561", "title": "《Mitochondrial transfer mediates endothelial cell engraftment through mitophagy》论文发表", "date_start": "2024-05-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体移植与能量医学报告或讨论可复核的学术证据。", "summary": "该节点将线粒体移植与能量医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1237" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体移植、能量医学与细胞供能修复", "notes": "第 229 轮补录：线粒体移植与能量医学；待本地复核。；日期补齐：Crossref 2024-05-01 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-562", "title": "《Mitochondrial transfer between cell crosstalk – An emerging role in mitochondrial quality control》论文发表", "date_start": "2023-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体移植与能量医学报告或讨论可复核的学术证据。", "summary": "该节点将线粒体移植与能量医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1238" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体移植、能量医学与细胞供能修复", "notes": "第 229 轮补录：线粒体移植与能量医学；待本地复核。；日期补齐：Crossref 2023-11 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-563", "title": "《Mitochondrial transfer in endothelial cells and vascular health》论文发表", "date_start": "2025-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体移植与能量医学报告或讨论可复核的学术证据。", "summary": "该节点将线粒体移植与能量医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1239" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体移植、能量医学与细胞供能修复", "notes": "第 229 轮补录：线粒体移植与能量医学；待本地复核。；日期补齐：Crossref 2025-05 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-564", "title": "《Small-molecule hypoxia therapy in mitochondrial disease》论文发表", "date_start": "2025-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体移植与能量医学报告或讨论可复核的学术证据。", "summary": "该节点将线粒体移植与能量医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1240" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体移植、能量医学与细胞供能修复", "notes": "第 229 轮补录：线粒体移植与能量医学；待本地复核。；日期补齐：Crossref 2025-03 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-565", "title": "《High Torque teno virus viremia predicts long-term mortality and reflects chronic low-grade inflammation (inflammaging) in geriatric inpatients》论文发表", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕炎症衰老与慢性炎症报告或讨论可复核的学术证据。", "summary": "该节点将炎症衰老与慢性炎症的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1241" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "炎症衰老、慢性炎症与免疫代谢维护", "notes": "第 230 轮补录：炎症衰老与慢性炎症；待本地复核。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-566", "title": "《InflammAging and Human Diversity: Expanding Horizons in Age-Related Chronic Disease》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕炎症衰老与慢性炎症报告或讨论可复核的学术证据。", "summary": "该节点将炎症衰老与慢性炎症的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1242" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "炎症衰老、慢性炎症与免疫代谢维护", "notes": "第 230 轮补录：炎症衰老与慢性炎症；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-567", "title": "《Targeting Macrophage Efferocytosis to Treat Chronic Inflammation in Cancer and Inflammaging》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕炎症衰老与慢性炎症报告或讨论可复核的学术证据。", "summary": "该节点将炎症衰老与慢性炎症的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1243" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "炎症衰老、慢性炎症与免疫代谢维护", "notes": "第 230 轮补录：炎症衰老与慢性炎症；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-568", "title": "《Inflammation and aging-related disease: A transdisciplinary inflammaging framework》论文发表", "date_start": "2024-10-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕炎症衰老与慢性炎症报告或讨论可复核的学术证据。", "summary": "该节点将炎症衰老与慢性炎症的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1244" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "炎症衰老、慢性炎症与免疫代谢维护", "notes": "第 230 轮补录：炎症衰老与慢性炎症；待本地复核。；日期补齐：Crossref 2024-10-01 (published-online, day, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-569", "title": "《New Perspectives on Gastric Inflammaging: Integrating Multi-Omics Mechanisms and Gerotherapeutic Strategies in Chronic Gastritis》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕炎症衰老与慢性炎症报告或讨论可复核的学术证据。", "summary": "该节点将炎症衰老与慢性炎症的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1245" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "炎症衰老、慢性炎症与免疫代谢维护", "notes": "第 230 轮补录：炎症衰老与慢性炎症；待本地复核。；日期补齐：Crossref 2025 (published-online, year, v3)", "created_at": "2026-08-07T05:03:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-570", "title": "《Role of Macrophages in Wound Healing》论文发表", "date_start": "2022-08-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕巨噬细胞与组织修复报告或讨论可复核的学术证据。", "summary": "该节点将巨噬细胞与组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1246" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "巨噬细胞、组织修复与免疫再生界面", "notes": "第 231 轮补录：巨噬细胞与组织修复；待本地复核。；日期补齐：Crossref 2022-08-30 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-571", "title": "《Macrophages in Tissue Repair, Regeneration, and Fibrosis》论文发表", "date_start": "2016-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕巨噬细胞与组织修复报告或讨论可复核的学术证据。", "summary": "该节点将巨噬细胞与组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1247" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "巨噬细胞、组织修复与免疫再生界面", "notes": "第 231 轮补录：巨噬细胞与组织修复；待本地复核。；日期补齐：Crossref 2016-03 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-572", "title": "《Tissue‐resident macrophages: then and now》论文发表", "date_start": "2015-03-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕巨噬细胞与组织修复报告或讨论可复核的学术证据。", "summary": "该节点将巨噬细胞与组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1248" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "巨噬细胞、组织修复与免疫再生界面", "notes": "第 231 轮补录：巨噬细胞与组织修复；待本地复核。；日期补齐：Crossref 2015-03-09 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-573", "title": "《Macrophage plasticity and polarization: in vivo veritas》论文发表", "date_start": "2012-03-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕巨噬细胞与组织修复报告或讨论可复核的学术证据。", "summary": "该节点将巨噬细胞与组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1249" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "巨噬细胞、组织修复与免疫再生界面", "notes": "第 231 轮补录：巨噬细胞与组织修复；待本地复核。；日期补齐：Crossref 2012-03-01 (published-print, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-574", "title": "《Macrophage polarization and plasticity in health and disease》论文发表", "date_start": "2012-03-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕巨噬细胞与组织修复报告或讨论可复核的学术证据。", "summary": "该节点将巨噬细胞与组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1250" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "巨噬细胞、组织修复与免疫再生界面", "notes": "第 231 轮补录：巨噬细胞与组织修复；待本地复核。；日期补齐：Crossref 2012-03-15 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-575", "title": "《Developing Therapeutically Enhanced Extracellular Vesicles for Atherosclerosis Therapy》论文发表", "date_start": "2025-04-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞外囊泡与外泌体治疗报告或讨论可复核的学术证据。", "summary": "该节点将细胞外囊泡与外泌体治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1251" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞外囊泡、外泌体与无细胞再生治疗", "notes": "第 232 轮补录：细胞外囊泡与外泌体治疗；待本地复核。；日期补齐：Crossref 2025-04-07 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-576", "title": "《Extracellular vesicles for the delivery of gene therapy》论文发表", "date_start": "2025-03-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞外囊泡与外泌体治疗报告或讨论可复核的学术证据。", "summary": "该节点将细胞外囊泡与外泌体治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1252" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞外囊泡、外泌体与无细胞再生治疗", "notes": "第 232 轮补录：细胞外囊泡与外泌体治疗；待本地复核。；日期补齐：Crossref 2025-03-04 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-577", "title": "《Antibody-displaying extracellular vesicles for targeted cancer therapy》论文发表", "date_start": "2024-05-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞外囊泡与外泌体治疗报告或讨论可复核的学术证据。", "summary": "该节点将细胞外囊泡与外泌体治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1253" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞外囊泡、外泌体与无细胞再生治疗", "notes": "第 232 轮补录：细胞外囊泡与外泌体治疗；待本地复核。；日期补齐：Crossref 2024-05-20 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-578", "title": "《Anticancer Therapy Targeting Cancer-Derived Extracellular Vesicles》论文发表", "date_start": "2024-02-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞外囊泡与外泌体治疗报告或讨论可复核的学术证据。", "summary": "该节点将细胞外囊泡与外泌体治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1254" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞外囊泡、外泌体与无细胞再生治疗", "notes": "第 232 轮补录：细胞外囊泡与外泌体治疗；待本地复核。；日期补齐：Crossref 2024-02-23 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-579", "title": "《Extracellular vesicles for developing targeted hearing loss therapy》论文发表", "date_start": "2024-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞外囊泡与外泌体治疗报告或讨论可复核的学术证据。", "summary": "该节点将细胞外囊泡与外泌体治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1255" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞外囊泡、外泌体与无细胞再生治疗", "notes": "第 232 轮补录：细胞外囊泡与外泌体治疗；待本地复核。；日期补齐：Crossref 2024-02 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-580", "title": "《Amino acid-based biological age clock and its implications for human health and aging》论文发表", "date_start": "2026-05-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物年龄时钟与干预反馈报告或讨论可复核的学术证据。", "summary": "该节点将生物年龄时钟与干预反馈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1256" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物年龄、时钟模型与干预反馈测量", "notes": "第 233 轮补录：生物年龄时钟与干预反馈；待本地复核。；日期补齐：Crossref 2026-05-22 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-581", "title": "《Gene clock predicts time to death in humans — and assesses ‘biological’ age》论文发表", "date_start": "2026-05-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物年龄时钟与干预反馈报告或讨论可复核的学术证据。", "summary": "该节点将生物年龄时钟与干预反馈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1257" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物年龄、时钟模型与干预反馈测量", "notes": "第 233 轮补录：生物年龄时钟与干预反馈；待本地复核。；日期补齐：Crossref 2026-05-27 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-582", "title": "《A urinary microRNA aging clock accurately predicts biological age》论文发表", "date_start": "2025-12-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物年龄时钟与干预反馈报告或讨论可复核的学术证据。", "summary": "该节点将生物年龄时钟与干预反馈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1258" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物年龄、时钟模型与干预反馈测量", "notes": "第 233 轮补录：生物年龄时钟与干预反馈；待本地复核。；日期补齐：Crossref 2025-12-15 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-583", "title": "《The immunosenescence clock: A new method for evaluating biological age and predicting mortality risk》论文发表", "date_start": "2025-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物年龄时钟与干预反馈报告或讨论可复核的学术证据。", "summary": "该节点将生物年龄时钟与干预反馈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1259" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物年龄、时钟模型与干预反馈测量", "notes": "第 233 轮补录：生物年龄时钟与干预反馈；待本地复核。；日期补齐：Crossref 2025-02 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-584", "title": "《Measuring biological age using a functionally interpretable multi‐tissue RNA clock》论文发表", "date_start": "2023-03-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物年龄时钟与干预反馈报告或讨论可复核的学术证据。", "summary": "该节点将生物年龄时钟与干预反馈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1260" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生物年龄、时钟模型与干预反馈测量", "notes": "第 233 轮补录：生物年龄时钟与干预反馈；待本地复核。；日期补齐：Crossref 2023-03-16 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-368", "title": "《Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice》论文发表", "date_start": "2026-06-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该文献围绕寿命临床试验设计报告或讨论可复核的学术证据。", "summary": "该节点将寿命临床试验设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1261" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "寿命干预、临床试验设计与健康寿命终点", "notes": "第 234 轮补录：寿命临床试验设计；待本地复核。；日期补齐：Crossref 2026-06-06 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-369", "title": "《Dietary cinnamon promotes longevity and extends healthspan via mTORC1 and autophagy signaling》论文发表", "date_start": "2025-01-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该文献围绕寿命临床试验设计报告或讨论可复核的学术证据。", "summary": "该节点将寿命临床试验设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1262" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "寿命干预、临床试验设计与健康寿命终点", "notes": "第 234 轮补录：寿命临床试验设计；待本地复核。；日期补齐：Crossref 2025-01-06 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-370", "title": "《Plasma proteomics links brain and immune system aging with healthspan and longevity》论文发表", "date_start": "2025-07-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该文献围绕寿命临床试验设计报告或讨论可复核的学术证据。", "summary": "该节点将寿命临床试验设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1263" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "寿命干预、临床试验设计与健康寿命终点", "notes": "第 234 轮补录：寿命临床试验设计；待本地复核。；日期补齐：Crossref 2025-07-09 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-372", "title": "《From telomeres and senescence to integrated longevity medicine: redefining the path to extended healthspan》论文发表", "date_start": "2025-05-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "thought", "claim": "该文献围绕寿命临床试验设计报告或讨论可复核的学术证据。", "summary": "该节点将寿命临床试验设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1265" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "寿命干预、临床试验设计与健康寿命终点", "notes": "第 234 轮补录：寿命临床试验设计；待本地复核。；日期补齐：Crossref 2025-05-05 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-585", "title": "《Dietary restriction in aging and longevity》论文发表", "date_start": "2026-03-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕雷帕霉素与长寿药物报告或讨论可复核的学术证据。", "summary": "该节点将雷帕霉素与长寿药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1266" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "雷帕霉素、mTOR信号与长寿干预", "notes": "第 235 轮补录：雷帕霉素与长寿药物；待本地复核。；日期补齐：Crossref 2026-03-06 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-586", "title": "《German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway》论文发表", "date_start": "2025-04-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕雷帕霉素与长寿药物报告或讨论可复核的学术证据。", "summary": "该节点将雷帕霉素与长寿药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1267" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "雷帕霉素、mTOR信号与长寿干预", "notes": "第 235 轮补录：雷帕霉素与长寿药物；待本地复核。；日期补齐：Crossref 2025-04-15 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-587", "title": "《Rapamycin for longevity: the pros, the cons, and future perspectives》论文发表", "date_start": "2025-06-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕雷帕霉素与长寿药物报告或讨论可复核的学术证据。", "summary": "该节点将雷帕霉素与长寿药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1268" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "雷帕霉素、mTOR信号与长寿干预", "notes": "第 235 轮补录：雷帕霉素与长寿药物；待本地复核。；日期补齐：Crossref 2025-06-20 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-588", "title": "《The bioavailability and blood levels of low-dose rapamycin for longevity in real-world cohorts of normative aging individuals》论文发表", "date_start": "2025-01-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕雷帕霉素与长寿药物报告或讨论可复核的学术证据。", "summary": "该节点将雷帕霉素与长寿药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1269" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "雷帕霉素、mTOR信号与长寿干预", "notes": "第 235 轮补录：雷帕霉素与长寿药物；待本地复核。；日期补齐：Crossref 2025-01-28 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-589", "title": "《Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity》论文发表", "date_start": "2020-06-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕雷帕霉素与长寿药物报告或讨论可复核的学术证据。", "summary": "该节点将雷帕霉素与长寿药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1270" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "雷帕霉素、mTOR信号与长寿干预", "notes": "第 235 轮补录：雷帕霉素与长寿药物；待本地复核。；日期补齐：Crossref 2020-06-23 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-042", "title": "《Emerging uncertainty on the anti-aging potential of metformin》论文发表", "date_start": "2025-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "policy", "claim": "该文献围绕二甲双胍与TAME试验报告或讨论可复核的学术证据。", "summary": "该节点将二甲双胍与TAME试验的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1271" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "二甲双胍、TAME试验与老年病预防", "notes": "第 236 轮补录：二甲双胍与TAME试验；待本地复核。；日期补齐：Crossref 2025-09 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-043", "title": "《Delaying Renal Aging: Metformin Holds Promise as a Potential Treatment》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "policy", "claim": "该文献围绕二甲双胍与TAME试验报告或讨论可复核的学术证据。", "summary": "该节点将二甲双胍与TAME试验的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1272" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "二甲双胍、TAME试验与老年病预防", "notes": "第 236 轮补录：二甲双胍与TAME试验；待本地复核。；日期补齐：Crossref 2024 (published-print, year, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-044", "title": "《Metformin decelerates aging clock in male monkeys》论文发表", "date_start": "2024-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "policy", "claim": "该文献围绕二甲双胍与TAME试验报告或讨论可复核的学术证据。", "summary": "该节点将二甲双胍与TAME试验的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1273" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "二甲双胍、TAME试验与老年病预防", "notes": "第 236 轮补录：二甲双胍与TAME试验；待本地复核。；日期补齐：Crossref 2024-10 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-045", "title": "《Metformin slows signs of primate aging》论文发表", "date_start": "2024-10-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "policy", "claim": "该文献围绕二甲双胍与TAME试验报告或讨论可复核的学术证据。", "summary": "该节点将二甲双胍与TAME试验的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1274" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "二甲双胍、TAME试验与老年病预防", "notes": "第 236 轮补录：二甲双胍与TAME试验；待本地复核。；日期补齐：Crossref 2024-10-22 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-046", "title": "《Metformin: decelerates biomarkers of aging clocks》论文发表", "date_start": "2024-11-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "policy", "claim": "该文献围绕二甲双胍与TAME试验报告或讨论可复核的学术证据。", "summary": "该节点将二甲双胍与TAME试验的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1275" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "二甲双胍、TAME试验与老年病预防", "notes": "第 236 轮补录：二甲双胍与TAME试验；待本地复核。；日期补齐：Crossref 2024-11-13 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-590", "title": "《Immunotherapy for senescent cell clearance: Hallmarks, strategies and translational challenges》论文发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕衰老细胞清除报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1276" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老细胞、senolytics与组织年轻化", "notes": "第 237 轮补录：衰老细胞清除；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-591", "title": "《Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕衰老细胞清除报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1277" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老细胞、senolytics与组织年轻化", "notes": "第 237 轮补录：衰老细胞清除；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-592", "title": "《SENESCENT CELL CLEARANCE PROTECTS THE OVARIAN RESERVE IN AGING MICE》论文发表", "date_start": "2024-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕衰老细胞清除报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1278" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老细胞、senolytics与组织年轻化", "notes": "第 237 轮补录：衰老细胞清除；待本地复核。；日期补齐：Crossref 2024-10 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-593", "title": "《Senolytic Therapy Enabled by Senescent Cell‐Sensitive Biomimetic Melanin Nano‐Senolytics》论文发表", "date_start": "2024-06-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕衰老细胞清除报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1279" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老细胞、senolytics与组织年轻化", "notes": "第 237 轮补录：衰老细胞清除；待本地复核。；日期补齐：Crossref 2024-06-11 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-594", "title": "《Senescent cells, senolytics and tissue repair: the devil may be in the dosing》论文发表", "date_start": "2023-01-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕衰老细胞清除报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1280" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老细胞、senolytics与组织年轻化", "notes": "第 237 轮补录：衰老细胞清除；待本地复核。；日期补齐：Crossref 2023-01-26 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-595", "title": "《NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere》论文发表", "date_start": "2025-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕端粒与染色体稳定性报告或讨论可复核的学术证据。", "summary": "该节点将端粒与染色体稳定性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1281" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "端粒、染色体稳定性与复制寿命", "notes": "第 238 轮补录：端粒与染色体稳定性；待本地复核。；日期补齐：Crossref 2025-07-01 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-596", "title": "《Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase》论文发表", "date_start": "2025-12-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕端粒与染色体稳定性报告或讨论可复核的学术证据。", "summary": "该节点将端粒与染色体稳定性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1282" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "端粒、染色体稳定性与复制寿命", "notes": "第 238 轮补录：端粒与染色体稳定性；待本地复核。；日期补齐：Crossref 2025-12-02 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-597", "title": "《Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice》论文发表", "date_start": "2010-11-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕端粒与染色体稳定性报告或讨论可复核的学术证据。", "summary": "该节点将端粒与染色体稳定性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1283" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "端粒、染色体稳定性与复制寿命", "notes": "第 238 轮补录：端粒与染色体稳定性；待本地复核。；日期补齐：Crossref 2010-11-28 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-598", "title": "《Purification of Human Telomerase Complexes Identifies Factors Involved in Telomerase Biogenesis and Telomere Length Regulation》论文发表", "date_start": "2007-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕端粒与染色体稳定性报告或讨论可复核的学术证据。", "summary": "该节点将端粒与染色体稳定性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1284" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "端粒、染色体稳定性与复制寿命", "notes": "第 238 轮补录：端粒与染色体稳定性；待本地复核。；日期补齐：Crossref 2007-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-599", "title": "《TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends》论文发表", "date_start": "2012-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕端粒与染色体稳定性报告或讨论可复核的学术证据。", "summary": "该节点将端粒与染色体稳定性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1285" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "端粒、染色体稳定性与复制寿命", "notes": "第 238 轮补录：端粒与染色体稳定性；待本地复核。；日期补齐：Crossref 2012-08 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-600", "title": "《Loss of DDI2 rewires proteostasis through CCN1-driven compensatory autophagy》论文发表", "date_start": "2026-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白稳态与自噬报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态与自噬的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1286" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与细胞质量控制", "notes": "第 239 轮补录：蛋白稳态与自噬；待本地复核。；日期补齐：Crossref 2026-03 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-601", "title": "《The coming of age of chaperone-mediated autophagy》论文发表", "date_start": "2018-04-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白稳态与自噬报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态与自噬的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1287" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与细胞质量控制", "notes": "第 239 轮补录：蛋白稳态与自噬；待本地复核。；日期补齐：Crossref 2018-04-06 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-602", "title": "《Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave》论文发表", "date_start": "2009-02-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白稳态与自噬报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态与自噬的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1288" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与细胞质量控制", "notes": "第 239 轮补录：蛋白稳态与自噬；待本地复核。；日期补齐：Crossref 2009-02-19 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-603", "title": "《Autophagy in the Pathogenesis of Disease》论文发表", "date_start": "2008-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白稳态与自噬报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态与自噬的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1289" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与细胞质量控制", "notes": "第 239 轮补录：蛋白稳态与自噬；待本地复核。；日期补齐：Crossref 2008-01 (published-print, month, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-604", "title": "《Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing》论文发表", "date_start": "2014-12-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白稳态与自噬报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态与自噬的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1290" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与细胞质量控制", "notes": "第 239 轮补录：蛋白稳态与自噬；待本地复核。；日期补齐：Crossref 2014-12-09 (published-online, day, v3)", "created_at": "2026-08-07T05:03:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-605", "title": "《Senescent cell heterogeneity in brain aging and neurodegenerative disease》论文发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性疾病干预报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性疾病干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1291" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行性疾病、衰老与神经保护干预", "notes": "第 240 轮补录：神经退行性疾病干预；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-606", "title": "《Shared and disease-specific glial gene expression changes in neurodegenerative diseases》论文发表", "date_start": "2023-02-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性疾病干预报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性疾病干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1292" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行性疾病、衰老与神经保护干预", "notes": "第 240 轮补录：神经退行性疾病干预；待本地复核。；日期补齐：Crossref 2023-02-13 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-607", "title": "《The untapped potential of targeting NRF2 in neurodegenerative disease》论文发表", "date_start": "2023-09-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性疾病干预报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性疾病干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1293" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行性疾病、衰老与神经保护干预", "notes": "第 240 轮补录：神经退行性疾病干预；待本地复核。；日期补齐：Crossref 2023-09-28 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-608", "title": "《Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases》论文发表", "date_start": "2022", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性疾病干预报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性疾病干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1294" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行性疾病、衰老与神经保护干预", "notes": "第 240 轮补录：神经退行性疾病干预；待本地复核。；日期补齐：Crossref 2022 (published-print, year, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-609", "title": "《Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性疾病干预报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性疾病干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1295" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行性疾病、衰老与神经保护干预", "notes": "第 240 轮补录：神经退行性疾病干预；待本地复核。；日期补齐：Crossref 2024 (published-online, year, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-610", "title": "《Reduced connection strength leads to enhancement of working memory capacity in cognitive training》论文发表", "date_start": "2025-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕认知增强与工作记忆报告或讨论可复核的学术证据。", "summary": "该节点将认知增强与工作记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1296" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、工作记忆与执行功能扩展", "notes": "第 241 轮补录：认知增强与工作记忆；待本地复核。；日期补齐：Crossref 2025-03 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-611", "title": "《The Effects of Working Memory Versus Adaptive Visual Search Control Training on Executive Cognitive Function》论文发表", "date_start": "2022-03-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕认知增强与工作记忆报告或讨论可复核的学术证据。", "summary": "该节点将认知增强与工作记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1297" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、工作记忆与执行功能扩展", "notes": "第 241 轮补录：认知增强与工作记忆；待本地复核。；日期补齐：Crossref 2022-03-23 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-612", "title": "《Behavioural and ERP Effects of Cognitive and Combined Cognitive and Physical Training on Working Memory and Executive Function in Healthy Older Adults》论文发表", "date_start": "2021-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕认知增强与工作记忆报告或讨论可复核的学术证据。", "summary": "该节点将认知增强与工作记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1298" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、工作记忆与执行功能扩展", "notes": "第 241 轮补录：认知增强与工作记忆；待本地复核。；日期补齐：Crossref 2021-03 (published-online, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-613", "title": "《Strategy training and working memory task performance》论文发表", "date_start": "2003-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕认知增强与工作记忆报告或讨论可复核的学术证据。", "summary": "该节点将认知增强与工作记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1299" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、工作记忆与执行功能扩展", "notes": "第 241 轮补录：认知增强与工作记忆；待本地复核。；日期补齐：Crossref 2003-11 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-614", "title": "《The Effects of Cognitive Training on Executive Function and Cognition》论文发表", "date_start": "2025-03-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕认知增强与工作记忆报告或讨论可复核的学术证据。", "summary": "该节点将认知增强与工作记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1300" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知增强、工作记忆与执行功能扩展", "notes": "第 241 轮补录：认知增强与工作记忆；待本地复核。；日期补齐：Crossref 2025-03-04 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-615", "title": "《Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep》论文发表", "date_start": "2025-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与大脑清洁报告或讨论可复核的学术证据。", "summary": "该节点将睡眠与大脑清洁的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1301" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠、类淋巴系统与大脑清洁", "notes": "第 242 轮补录：睡眠与大脑清洁；待本地复核。；日期补齐：Crossref 2025-02 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-616", "title": "《Sleep Drives Metabolite Clearance from the Adult Brain》论文发表", "date_start": "2013-10-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与大脑清洁报告或讨论可复核的学术证据。", "summary": "该节点将睡眠与大脑清洁的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1302" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠、类淋巴系统与大脑清洁", "notes": "第 242 轮补录：睡眠与大脑清洁；待本地复核。；日期补齐：Crossref 2013-10-18 (published-print, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-617", "title": "《The Glymphatic System and Waste Clearance with Brain Aging: A Review》论文发表", "date_start": "2018-07-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与大脑清洁报告或讨论可复核的学术证据。", "summary": "该节点将睡眠与大脑清洁的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1303" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠、类淋巴系统与大脑清洁", "notes": "第 242 轮补录：睡眠与大脑清洁；待本地复核。；日期补齐：Crossref 2018-07-11 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-618", "title": "《Sleep Facilitates Clearance of Metabolites from the Brain: Glymphatic Function in Aging and Neurodegenerative Diseases》论文发表", "date_start": "2013-12-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与大脑清洁报告或讨论可复核的学术证据。", "summary": "该节点将睡眠与大脑清洁的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1304" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠、类淋巴系统与大脑清洁", "notes": "第 242 轮补录：睡眠与大脑清洁；待本地复核。；日期补齐：Crossref 2013-12-01 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-619", "title": "《Sleep-circadian modulation of autophagy and glymphatic function: failure of coordinated brain clearance in Parkinson’s disease》论文发表", "date_start": "2026-06-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与大脑清洁报告或讨论可复核的学术证据。", "summary": "该节点将睡眠与大脑清洁的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1305" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "睡眠、类淋巴系统与大脑清洁", "notes": "第 242 轮补录：睡眠与大脑清洁；待本地复核。；日期补齐：Crossref 2026-06-08 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-620", "title": "《Continuous tracking using deep learning-based decoding for noninvasive brain–computer interface》论文发表", "date_start": "2024-04-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口语音解码报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口语音解码的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1306" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、语音解码与沟通能力重建", "notes": "第 243 轮补录：脑机接口语音解码；待本地复核。；日期补齐：Crossref 2024-04-30 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-621", "title": "《A high-performance speech neuroprosthesis》论文发表", "date_start": "2023-08-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口语音解码报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口语音解码的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1307" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、语音解码与沟通能力重建", "notes": "第 243 轮补录：脑机接口语音解码；待本地复核。；日期补齐：Crossref 2023-08-23 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-622", "title": "《Using adversarial networks to extend brain computer interface decoding accuracy over time》论文发表", "date_start": "2023-08-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口语音解码报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口语音解码的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1308" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、语音解码与沟通能力重建", "notes": "第 243 轮补录：脑机接口语音解码；待本地复核。；日期补齐：Crossref 2023-08-23 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-623", "title": "《Bilingual speech neuroprosthesis》论文发表", "date_start": "2024-08-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口语音解码报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口语音解码的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1309" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、语音解码与沟通能力重建", "notes": "第 243 轮补录：脑机接口语音解码；待本地复核。；日期补齐：Crossref 2024-08-21 (published-print, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-624", "title": "《Brain-Computer Interface: Applications to Speech Decoding and Synthesis to Augment Communication》论文发表", "date_start": "2022-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口语音解码报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口语音解码的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1310" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、语音解码与沟通能力重建", "notes": "第 243 轮补录：脑机接口语音解码；待本地复核。；日期补齐：Crossref 2022-01 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-373", "title": "《Memory editing from science fiction to clinical practice》论文发表", "date_start": "2019-07-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕记忆编辑与创伤后应激报告或讨论可复核的学术证据。", "summary": "该节点将记忆编辑与创伤后应激的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1311" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "记忆编辑、创伤后应激与身份连续性", "notes": "第 244 轮补录：记忆编辑与创伤后应激；待本地复核。；日期补齐：Crossref 2019-07-31 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-374", "title": "《Reconsolidation: maintaining memory relevance》论文发表", "date_start": "2009-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕记忆编辑与创伤后应激报告或讨论可复核的学术证据。", "summary": "该节点将记忆编辑与创伤后应激的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1312" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "记忆编辑、创伤后应激与身份连续性", "notes": "第 244 轮补录：记忆编辑与创伤后应激；待本地复核。；日期补齐：Crossref 2009-08 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-375", "title": "《Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation》论文发表", "date_start": "2026-02-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕记忆编辑与创伤后应激报告或讨论可复核的学术证据。", "summary": "该节点将记忆编辑与创伤后应激的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1313" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "记忆编辑、创伤后应激与身份连续性", "notes": "第 244 轮补录：记忆编辑与创伤后应激；待本地复核。；日期补齐：Crossref 2026-02-09 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-376", "title": "《Effects of propranolol on the modification of trauma memory reconsolidation in PTSD patients: A systematic review and meta-analysis》论文发表", "date_start": "2022-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕记忆编辑与创伤后应激报告或讨论可复核的学术证据。", "summary": "该节点将记忆编辑与创伤后应激的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1314" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "记忆编辑、创伤后应激与身份连续性", "notes": "第 244 轮补录：记忆编辑与创伤后应激；待本地复核。；日期补齐：Crossref 2022-06 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-377", "title": "《A clinician's perspective on memory reconsolidation as the primary basis for psychotherapeutic change in posttraumatic stress disorder (PTSD)》论文发表", "date_start": "2015-06-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕记忆编辑与创伤后应激报告或讨论可复核的学术证据。", "summary": "该节点将记忆编辑与创伤后应激的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1315" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "记忆编辑、创伤后应激与身份连续性", "notes": "第 244 轮补录：记忆编辑与创伤后应激；待本地复核。；日期补齐：Crossref 2015-06-08 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-625", "title": "《Digital Twin Technology: New Frontiers for Personalized Healthcare》论文发表", "date_start": "2023-04-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与个性化健康报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与个性化健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1316" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、个性化健康与预测医学", "notes": "第 245 轮补录：数字孪生与个性化健康；待本地复核。；日期补齐：Crossref 2023-04-19 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-626", "title": "《Causal digital twin modeling of periodontal healing: personalized prediction of low-level laser therapy benefit using a tooth-graph ODE transformer》论文发表", "date_start": "2026-02-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与个性化健康报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与个性化健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1317" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、个性化健康与预测医学", "notes": "第 245 轮补录：数字孪生与个性化健康；待本地复核。；日期补齐：Crossref 2026-02-24 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-627", "title": "《iDT-diet: Toward Personalized Health Forecasting-An Intelligent Digital Twin Model for Diet-Influenced Biomarker Trajectories (Student Abstract)》论文发表", "date_start": "2026-03-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与个性化健康报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与个性化健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1318" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、个性化健康与预测医学", "notes": "第 245 轮补录：数字孪生与个性化健康；待本地复核。；日期补齐：Crossref 2026-03-14 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-628", "title": "《Innovative digital twin framework for early risk detection and personalized perinatal healthcare》论文发表", "date_start": "2026-07-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与个性化健康报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与个性化健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1319" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、个性化健康与预测医学", "notes": "第 245 轮补录：数字孪生与个性化健康；待本地复核。；日期补齐：Crossref 2026-07-27 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-629", "title": "《Digital Twin Model: A Real-Time Emotion Recognition System for Personalized Healthcare》论文发表", "date_start": "2022", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与个性化健康报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与个性化健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1320" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、个性化健康与预测医学", "notes": "第 245 轮补录：数字孪生与个性化健康；待本地复核。；日期补齐：Crossref 2022 (published-print, year, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-630", "title": "《Accelerating drug discovery, development, and clinical trials by artificial intelligence》论文发表", "date_start": "2024-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕AI药物发现与临床试验报告或讨论可复核的学术证据。", "summary": "该节点将AI药物发现与临床试验的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1321" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI药物发现、临床试验与生物医学加速", "notes": "第 246 轮补录：AI药物发现与临床试验；待本地复核。；日期补齐：Crossref 2024-09 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-631", "title": "《Generative artificial intelligence empowers digital twins in drug discovery and clinical trials》论文发表", "date_start": "2023-10-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕AI药物发现与临床试验报告或讨论可复核的学术证据。", "summary": "该节点将AI药物发现与临床试验的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1322" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI药物发现、临床试验与生物医学加速", "notes": "第 246 轮补录：AI药物发现与临床试验；待本地复核。；日期补齐：Crossref 2023-10-27 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-632", "title": "《Advancement of Artificial Intelligence in Drug Discovery: A Comprehensive Review》论文发表", "date_start": "2025-03-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕AI药物发现与临床试验报告或讨论可复核的学术证据。", "summary": "该节点将AI药物发现与临床试验的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1323" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI药物发现、临床试验与生物医学加速", "notes": "第 246 轮补录：AI药物发现与临床试验；待本地复核。；日期补齐：Crossref 2025-03-20 (published-print, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-633", "title": "《Artificial intelligence and machine learning in drug discovery: From lead discovery to clinical validation (2020–2025)》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕AI药物发现与临床试验报告或讨论可复核的学术证据。", "summary": "该节点将AI药物发现与临床试验的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1324" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI药物发现、临床试验与生物医学加速", "notes": "第 246 轮补录：AI药物发现与临床试验；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-634", "title": "《Artificial Intelligence in Drug Development - Revolutionizing Drug Discovery and Clinical Trials》论文发表", "date_start": "2024-02-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕AI药物发现与临床试验报告或讨论可复核的学术证据。", "summary": "该节点将AI药物发现与临床试验的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1325" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "AI药物发现、临床试验与生物医学加速", "notes": "第 246 轮补录：AI药物发现与临床试验；待本地复核。；日期补齐：Crossref 2024-02-01 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-635", "title": "《An autonomous laboratory for the accelerated synthesis of inorganic materials》论文发表", "date_start": "2023-11-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕生成式AI与科学自动化报告或讨论可复核的学术证据。", "summary": "该节点将生成式AI与科学自动化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1326" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生成式AI、自主实验室与科研自动化", "notes": "第 247 轮补录：生成式AI与科学自动化；待本地复核。；日期补齐：Crossref 2023-11-29 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-636", "title": "《Autonomous chemical research with large language models》论文发表", "date_start": "2023-12-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕生成式AI与科学自动化报告或讨论可复核的学术证据。", "summary": "该节点将生成式AI与科学自动化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1327" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生成式AI、自主实验室与科研自动化", "notes": "第 247 轮补录：生成式AI与科学自动化；待本地复核。；日期补齐：Crossref 2023-12-20 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-637", "title": "《Scaling deep learning for materials discovery》论文发表", "date_start": "2023-11-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕生成式AI与科学自动化报告或讨论可复核的学术证据。", "summary": "该节点将生成式AI与科学自动化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1328" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生成式AI、自主实验室与科研自动化", "notes": "第 247 轮补录：生成式AI与科学自动化；待本地复核。；日期补齐：Crossref 2023-11-29 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-638", "title": "《Data-Driven Design and Autonomous Experimentation in Soft and Biological Materials Engineering》论文发表", "date_start": "2022-06-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕生成式AI与科学自动化报告或讨论可复核的学术证据。", "summary": "该节点将生成式AI与科学自动化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1329" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生成式AI、自主实验室与科研自动化", "notes": "第 247 轮补录：生成式AI与科学自动化；待本地复核。；日期补齐：Crossref 2022-06-10 (published-print, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-639", "title": "《Agentic and Generative AI for Autonomous Energy Systems: Reference Architecture, Open Challenges, and Research Agenda》论文发表", "date_start": "2026-05-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕生成式AI与科学自动化报告或讨论可复核的学术证据。", "summary": "该节点将生成式AI与科学自动化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1330" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生成式AI、自主实验室与科研自动化", "notes": "第 247 轮补录：生成式AI与科学自动化；待本地复核。；日期补齐：Crossref 2026-05-20 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-378", "title": "《Healthy dietary patterns, longevity genes, and life expectancy: A prospective cohort study》论文发表", "date_start": "2026-02-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论与建模报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度理论与建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1331" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度、寿命延展与健康寿命建模", "notes": "第 248 轮补录：长寿逃逸速度理论与建模；待本地复核。；日期补齐：Crossref 2026-02-13 (published-print, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-379", "title": "《Modifiable risk factors attenuated longevity genetic predisposition on life expectancy in the oldest old》论文发表", "date_start": "2026-05-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论与建模报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度理论与建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1332" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度、寿命延展与健康寿命建模", "notes": "第 248 轮补录：长寿逃逸速度理论与建模；待本地复核。；日期补齐：Crossref 2026-05-05 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-380", "title": "《Longevity Escape Velocity Medicine: A New Medical Specialty for Longevity?》论文发表", "date_start": "2018-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论与建模报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度理论与建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1333" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度、寿命延展与健康寿命建模", "notes": "第 248 轮补录：长寿逃逸速度理论与建模；待本地复核。；日期补齐：Crossref 2018-02 (published-online, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-381", "title": "《Addressing Longevity, Life Expectancy and Health Life Expectancy》论文发表", "date_start": "2015-11-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论与建模报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度理论与建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1334" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度、寿命延展与健康寿命建模", "notes": "第 248 轮补录：长寿逃逸速度理论与建模；待本地复核。；日期补齐：Crossref 2015-11-06 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-382", "title": "《The Effect of Exceptional Parental Longevity on Life Expectancy》论文发表", "date_start": "2012-06-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论与建模报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度理论与建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1335" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度、寿命延展与健康寿命建模", "notes": "第 248 轮补录：长寿逃逸速度理论与建模；待本地复核。；日期补齐：Crossref 2012-06-12 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-383", "title": "《CONTENT OF PERSONAL IDENTITY AT DIFFERENT STAGES OF THE LIFE COURSE》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体持续性建模报告或讨论可复核的学术证据。", "summary": "该节点将主体持续性建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1336" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "主体持续性、生命路径与未来选择权建模", "notes": "第 249 轮补录：主体持续性建模；待本地复核。；日期补齐：Crossref 2024 (published-online, year, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-384", "title": "《Personal network dynamics across the life course: A relationship-related structural approach》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体持续性建模报告或讨论可复核的学术证据。", "summary": "该节点将主体持续性建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1337" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "主体持续性、生命路径与未来选择权建模", "notes": "第 249 轮补录：主体持续性建模；待本地复核。；日期补齐：Crossref 2023-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-385", "title": "《Personality Development: Continuity and Change Over the Life Course》论文发表", "date_start": "2010-01-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体持续性建模报告或讨论可复核的学术证据。", "summary": "该节点将主体持续性建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1338" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "主体持续性、生命路径与未来选择权建模", "notes": "第 249 轮补录：主体持续性建模；待本地复核。；日期补齐：Crossref 2010-01-01 (published-print, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-386", "title": "《Life Course Transitions and Social Identity Change》论文发表", "date_start": "2005", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体持续性建模报告或讨论可复核的学术证据。", "summary": "该节点将主体持续性建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1339" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "主体持续性、生命路径与未来选择权建模", "notes": "第 249 轮补录：主体持续性建模；待本地复核。；日期补齐：Crossref 2005 (published-print, year, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-387", "title": "《Bodily continuity, personal identity and life after death》论文发表", "date_start": "1990-07", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体持续性建模报告或讨论可复核的学术证据。", "summary": "该节点将主体持续性建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1340" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "主体持续性、生命路径与未来选择权建模", "notes": "第 249 轮补录：主体持续性建模；待本地复核。；日期补齐：Crossref 1990-07 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-047", "title": "《Towards the Governance of Global Systemic Risk》论文发表", "date_start": "2025-05-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕风险治理与全球合作报告或讨论可复核的学术证据。", "summary": "该节点将风险治理与全球合作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1341" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "技术风险、全球治理与长期安全合作", "notes": "第 250 轮补录：风险治理与全球合作；待本地复核。；日期补齐：Crossref 2025-05-13 (published-print, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-048", "title": "《Localized Development Gaps in Global Governance: The Case of Disaster Risk Reduction in Oceania》论文发表", "date_start": "2017-08-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕风险治理与全球合作报告或讨论可复核的学术证据。", "summary": "该节点将风险治理与全球合作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1342" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "技术风险、全球治理与长期安全合作", "notes": "第 250 轮补录：风险治理与全球合作；待本地复核。；日期补齐：Crossref 2017-08-19 (published-print, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-049", "title": "《Whose risk counts? Climate risk frames in global green finance governance complex》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕风险治理与全球合作报告或讨论可复核的学术证据。", "summary": "该节点将风险治理与全球合作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1343" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "技术风险、全球治理与长期安全合作", "notes": "第 250 轮补录：风险治理与全球合作；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-050", "title": "《The Risk of Global Environmental Change to Economic Sustainability and Law: Help from Digital Technology and Governance Regulation》论文发表", "date_start": "2025-08-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕风险治理与全球合作报告或讨论可复核的学术证据。", "summary": "该节点将风险治理与全球合作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1344" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "技术风险、全球治理与长期安全合作", "notes": "第 250 轮补录：风险治理与全球合作；待本地复核。；日期补齐：Crossref 2025-08-05 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-051", "title": "《Technology-Enabled Adaptive Knowledge Architecture for Humanitarian Governance (TAKAH) as an Enabler for Disaster Risk Management: An African-Global Comparative Analysis》论文发表", "date_start": "2026-07-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕风险治理与全球合作报告或讨论可复核的学术证据。", "summary": "该节点将风险治理与全球合作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1345" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "技术风险、全球治理与长期安全合作", "notes": "第 250 轮补录：风险治理与全球合作；待本地复核。；日期补齐：Crossref 2026-07-27 (published-online, day, v3)", "created_at": "2026-08-07T05:03:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-640", "title": "《Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury》论文发表", "date_start": "2026-03-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕神经干细胞疗法报告或讨论可复核的学术证据。", "summary": "该节点将神经干细胞疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1346" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经干细胞、脑修复与神经再生治疗", "notes": "第 251 轮补录：神经干细胞疗法；待本地复核。；日期补齐：Crossref 2026-03-05 (published-online, day, v3)", "created_at": "2026-08-07T06:01:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-641", "title": "《How neural stem cell therapy promotes brain repair after stroke》论文发表", "date_start": "2025-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕神经干细胞疗法报告或讨论可复核的学术证据。", "summary": "该节点将神经干细胞疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1347" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经干细胞、脑修复与神经再生治疗", "notes": "第 251 轮补录：神经干细胞疗法；待本地复核。；日期补齐：Crossref 2025-06 (published-print, month, v3)", "created_at": "2026-08-07T06:01:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-642", "title": "《Neural stem cells of the subventricular zone: A potential stem cell pool for brain repair in Parkinson’s disease》论文发表", "date_start": "2025-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕神经干细胞疗法报告或讨论可复核的学术证据。", "summary": "该节点将神经干细胞疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1348" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经干细胞、脑修复与神经再生治疗", "notes": "第 251 轮补录：神经干细胞疗法；待本地复核。；日期补齐：Crossref 2025-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-643", "title": "《A Coated Sponge: Toward Neonatal Brain Repair》论文发表", "date_start": "2018-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕神经干细胞疗法报告或讨论可复核的学术证据。", "summary": "该节点将神经干细胞疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1349" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经干细胞、脑修复与神经再生治疗", "notes": "第 251 轮补录：神经干细胞疗法；待本地复核。；日期补齐：Crossref 2018-01 (published-print, month, v3)", "created_at": "2026-08-07T06:01:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-644", "title": "《Plug and Play Brain: Understanding Integration of Transplanted Neurons for Brain Repair》论文发表", "date_start": "2016-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕神经干细胞疗法报告或讨论可复核的学术证据。", "summary": "该节点将神经干细胞疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1350" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经干细胞、脑修复与神经再生治疗", "notes": "第 251 轮补录：神经干细胞疗法；待本地复核。；日期补齐：Crossref 2016-12 (published-print, month, v3)", "created_at": "2026-08-07T06:01:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-645", "title": "《Oligodendrocyte-encoded lactate dehydrogenase A couples glycolysis to remyelination via protein lactylation》论文发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕少突胶质细胞与髓鞘再生报告或讨论可复核的学术证据。", "summary": "该节点将少突胶质细胞与髓鞘再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1351" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "少突胶质细胞、髓鞘再生与白质修复", "notes": "第 252 轮补录：少突胶质细胞与髓鞘再生；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-646", "title": "《Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination》论文发表", "date_start": "2024-08-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕少突胶质细胞与髓鞘再生报告或讨论可复核的学术证据。", "summary": "该节点将少突胶质细胞与髓鞘再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1352" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "少突胶质细胞、髓鞘再生与白质修复", "notes": "第 252 轮补录：少突胶质细胞与髓鞘再生；待本地复核。；日期补齐：Crossref 2024-08-20 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-647", "title": "《Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism》论文发表", "date_start": "2024-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕少突胶质细胞与髓鞘再生报告或讨论可复核的学术证据。", "summary": "该节点将少突胶质细胞与髓鞘再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1353" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "少突胶质细胞、髓鞘再生与白质修复", "notes": "第 252 轮补录：少突胶质细胞与髓鞘再生；待本地复核。；日期补齐：Crossref 2024-08 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-648", "title": "《Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model》论文发表", "date_start": "2023-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕少突胶质细胞与髓鞘再生报告或讨论可复核的学术证据。", "summary": "该节点将少突胶质细胞与髓鞘再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1354" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "少突胶质细胞、髓鞘再生与白质修复", "notes": "第 252 轮补录：少突胶质细胞与髓鞘再生；待本地复核。；日期补齐：Crossref 2023-02 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-649", "title": "《Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice》论文发表", "date_start": "2023-03-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕少突胶质细胞与髓鞘再生报告或讨论可复核的学术证据。", "summary": "该节点将少突胶质细胞与髓鞘再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1355" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "少突胶质细胞、髓鞘再生与白质修复", "notes": "第 252 轮补录：少突胶质细胞与髓鞘再生；待本地复核。；日期补齐：Crossref 2023-03-16 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-650", "title": "《Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair》论文发表", "date_start": "2026-02-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕星形胶质细胞与脑修复报告或讨论可复核的学术证据。", "summary": "该节点将星形胶质细胞与脑修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1356" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "星形胶质细胞、反应性胶质与脑修复", "notes": "第 253 轮补录：星形胶质细胞与脑修复；待本地复核。；日期补齐：Crossref 2026-02-26 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-651", "title": "《Mechanisms of astrocyte aging in reactivity and disease》论文发表", "date_start": "2025-02-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕星形胶质细胞与脑修复报告或讨论可复核的学术证据。", "summary": "该节点将星形胶质细胞与脑修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1357" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "星形胶质细胞、反应性胶质与脑修复", "notes": "第 253 轮补录：星形胶质细胞与脑修复；待本地复核。；日期补齐：Crossref 2025-02-21 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-652", "title": "《A molecular switch for neuroprotective astrocyte reactivity》论文发表", "date_start": "2023-12-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕星形胶质细胞与脑修复报告或讨论可复核的学术证据。", "summary": "该节点将星形胶质细胞与脑修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1358" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "星形胶质细胞、反应性胶质与脑修复", "notes": "第 253 轮补录：星形胶质细胞与脑修复；待本地复核。；日期补齐：Crossref 2023-12-12 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-653", "title": "《Dysregulation of polarity proteins in astrocyte reactivity》论文发表", "date_start": "2023-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕星形胶质细胞与脑修复报告或讨论可复核的学术证据。", "summary": "该节点将星形胶质细胞与脑修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1359" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "星形胶质细胞、反应性胶质与脑修复", "notes": "第 253 轮补录：星形胶质细胞与脑修复；待本地复核。；日期补齐：Crossref 2023-04 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-654", "title": "《Astrocyte Reactivity in Alzheimer’s Disease: Therapeutic Opportunities to Promote Repair》论文发表", "date_start": "2022-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕星形胶质细胞与脑修复报告或讨论可复核的学术证据。", "summary": "该节点将星形胶质细胞与脑修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1360" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "星形胶质细胞、反应性胶质与脑修复", "notes": "第 253 轮补录：星形胶质细胞与脑修复；待本地复核。；日期补齐：Crossref 2022-01 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-655", "title": "《Neuroimmune dynamics and brain aging: mechanisms and consequences》论文发表", "date_start": "2025-11-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕小胶质细胞与神经免疫报告或讨论可复核的学术证据。", "summary": "该节点将小胶质细胞与神经免疫的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1361" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "小胶质细胞、神经免疫与脑稳态", "notes": "第 254 轮补录：小胶质细胞与神经免疫；待本地复核。；日期补齐：Crossref 2025-11-19 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-656", "title": "《An in vivo neuroimmune organoid model to study human microglia phenotypes》论文发表", "date_start": "2023-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕小胶质细胞与神经免疫报告或讨论可复核的学术证据。", "summary": "该节点将小胶质细胞与神经免疫的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1362" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "小胶质细胞、神经免疫与脑稳态", "notes": "第 254 轮补录：小胶质细胞与神经免疫；待本地复核。；日期补齐：Crossref 2023-05 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-657", "title": "《Microglia modulate neurodevelopment in human neuroimmune organoids》论文发表", "date_start": "2021-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕小胶质细胞与神经免疫报告或讨论可复核的学术证据。", "summary": "该节点将小胶质细胞与神经免疫的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1363" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "小胶质细胞、神经免疫与脑稳态", "notes": "第 254 轮补录：小胶质细胞与神经免疫；待本地复核。；日期补齐：Crossref 2021-12 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-658", "title": "《Aging Microglia—Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases》论文发表", "date_start": "2017-06-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕小胶质细胞与神经免疫报告或讨论可复核的学术证据。", "summary": "该节点将小胶质细胞与神经免疫的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1364" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "小胶质细胞、神经免疫与脑稳态", "notes": "第 254 轮补录：小胶质细胞与神经免疫；待本地复核。；日期补齐：Crossref 2017-06-14 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-659", "title": "《The cellular choreography of brain aging: a neuroimmune network perspective》论文发表", "date_start": "2026-05-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕小胶质细胞与神经免疫报告或讨论可复核的学术证据。", "summary": "该节点将小胶质细胞与神经免疫的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1365" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "小胶质细胞、神经免疫与脑稳态", "notes": "第 254 轮补录：小胶质细胞与神经免疫；待本地复核。；日期补齐：Crossref 2026-05-22 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-660", "title": "《Temporal dynamics of neurovascular unit changes following blood-brain barrier opening in the putamen of non-human primates》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕血脑屏障与神经血管单元报告或讨论可复核的学术证据。", "summary": "该节点将血脑屏障与神经血管单元的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1366" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "血脑屏障、神经血管单元与脑灌注", "notes": "第 255 轮补录：血脑屏障与神经血管单元；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-661", "title": "《Contributions of blood–brain barrier imaging to neurovascular unit pathophysiology of Alzheimer’s disease and related dementias》论文发表", "date_start": "2023-02-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕血脑屏障与神经血管单元报告或讨论可复核的学术证据。", "summary": "该节点将血脑屏障与神经血管单元的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1367" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "血脑屏障、神经血管单元与脑灌注", "notes": "第 255 轮补录：血脑屏障与神经血管单元；待本地复核。；日期补齐：Crossref 2023-02-09 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-662", "title": "《Engineering Neurovascular Unit and Blood–Brain Barrier for Ischemic Stroke Modeling》论文发表", "date_start": "2023-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕血脑屏障与神经血管单元报告或讨论可复核的学术证据。", "summary": "该节点将血脑屏障与神经血管单元的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1368" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "血脑屏障、神经血管单元与脑灌注", "notes": "第 255 轮补录：血脑屏障与神经血管单元；待本地复核。；日期补齐：Crossref 2023-05 (published-online, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-664", "title": "《Multiple sclerosis: etiology in the context of neurovascular unit and immune system involvement and advancements with in vitro blood–brain barrier models》论文发表", "date_start": "2025-06-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕血脑屏障与神经血管单元报告或讨论可复核的学术证据。", "summary": "该节点将血脑屏障与神经血管单元的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1370" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "血脑屏障、神经血管单元与脑灌注", "notes": "第 255 轮补录：血脑屏障与神经血管单元；待本地复核。；日期补齐：Crossref 2025-06-10 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-665", "title": "《Neuronal Necroptosis Drives Neuroinflammation and Cognitive Decline Independent of Neuronal Cell Death》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经炎症与认知保护报告或讨论可复核的学术证据。", "summary": "该节点将神经炎症与认知保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1371" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经炎症、认知衰退与神经保护", "notes": "第 256 轮补录：神经炎症与认知保护；待本地复核。；日期补齐：Crossref 2025 (published-online, year, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-666", "title": "《Cognitive frailty: A comprehensive clinical paradigm beyond cognitive decline》论文发表", "date_start": "2025-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经炎症与认知保护报告或讨论可复核的学术证据。", "summary": "该节点将神经炎症与认知保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1372" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经炎症、认知衰退与神经保护", "notes": "第 256 轮补录：神经炎症与认知保护；待本地复核。；日期补齐：Crossref 2025-06 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-667", "title": "《P2Y1R silencing in Astrocytes Protected Neuroinflammation and Cognitive Decline in a Mouse Model of Alzheimer's Disease》论文发表", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经炎症与认知保护报告或讨论可复核的学术证据。", "summary": "该节点将神经炎症与认知保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1373" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经炎症、认知衰退与神经保护", "notes": "第 256 轮补录：神经炎症与认知保护；待本地复核。；日期补齐：Crossref 2023 (published-online, year, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-668", "title": "《Periodontitis-induced neuroinflammation triggers IFITM3-Aβ axis to cause alzheimer’s disease-like pathology and cognitive decline》论文发表", "date_start": "2025-07-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经炎症与认知保护报告或讨论可复核的学术证据。", "summary": "该节点将神经炎症与认知保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1374" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经炎症、认知衰退与神经保护", "notes": "第 256 轮补录：神经炎症与认知保护；待本地复核。；日期补齐：Crossref 2025-07-19 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-669", "title": "《Neuroinflammation and cognitive decline: a TSPO‐PET imaging study.》论文发表", "date_start": "2023-12-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经炎症与认知保护报告或讨论可复核的学术证据。", "summary": "该节点将神经炎症与认知保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1375" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经炎症、认知衰退与神经保护", "notes": "第 256 轮补录：神经炎症与认知保护；待本地复核。；日期补齐：Crossref 2023-12-25 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-670", "title": "《KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury》论文发表", "date_start": "2024-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕脑类器官与神经发育报告或讨论可复核的学术证据。", "summary": "该节点将脑类器官与神经发育的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1376" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑类器官、神经发育与疾病建模", "notes": "第 257 轮补录：脑类器官与神经发育；待本地复核。；日期补齐：Crossref 2024-04 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-671", "title": "《Cortical brain organoid as a model to study microgravity exposure》论文发表", "date_start": "2022-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕脑类器官与神经发育报告或讨论可复核的学术证据。", "summary": "该节点将脑类器官与神经发育的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1377" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑类器官、神经发育与疾病建模", "notes": "第 257 轮补录：脑类器官与神经发育；待本地复核。；日期补齐：Crossref 2022-12-31 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-672", "title": "《Modest Neurodevelopment Impacts of APOE4 in a Human Brain Organoid Model of Low-Grade SARS-CoV-2 Infection》论文发表", "date_start": "2026-02-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕脑类器官与神经发育报告或讨论可复核的学术证据。", "summary": "该节点将脑类器官与神经发育的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1378" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑类器官、神经发育与疾病建模", "notes": "第 257 轮补录：脑类器官与神经发育；待本地复核。；日期补齐：Crossref 2026-02-16 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-673", "title": "《Brain organoid models of Huntington's disease shift the focus towards neurodevelopment》论文发表", "date_start": "2025-10-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕脑类器官与神经发育报告或讨论可复核的学术证据。", "summary": "该节点将脑类器官与神经发育的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1379" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑类器官、神经发育与疾病建模", "notes": "第 257 轮补录：脑类器官与神经发育；待本地复核。；日期补齐：Crossref 2025-10-28 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-674", "title": "《Novel model of cortical–meningeal organoid co-culture system improves human cortical brain organoid cytoarchitecture》论文发表", "date_start": "2023-05-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕脑类器官与神经发育报告或讨论可复核的学术证据。", "summary": "该节点将脑类器官与神经发育的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1380" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑类器官、神经发育与疾病建模", "notes": "第 257 轮补录：脑类器官与神经发育；待本地复核。；日期补齐：Crossref 2023-05-14 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-675", "title": "《Whole-body connectome of a segmented annelid larva》论文发表", "date_start": "2025-08-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕全脑连接组图谱报告或讨论可复核的学术证据。", "summary": "该节点将全脑连接组图谱的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1381" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "全脑连接组、神经图谱与脑基础设施", "notes": "第 258 轮补录：全脑连接组图谱；待本地复核。；日期补齐：Crossref 2025-08-27 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-676", "title": "《Generative network modeling reveals quantitative definitions of bilateral symmetry exhibited by a whole insect brain connectome》论文发表", "date_start": "2023-03-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕全脑连接组图谱报告或讨论可复核的学术证据。", "summary": "该节点将全脑连接组图谱的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1382" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "全脑连接组、神经图谱与脑基础设施", "notes": "第 258 轮补录：全脑连接组图谱；待本地复核。；日期补齐：Crossref 2023-03-28 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-677", "title": "《Fly-brain connectome helps to make predictions about neural activity》论文发表", "date_start": "2024-09-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕全脑连接组图谱报告或讨论可复核的学术证据。", "summary": "该节点将全脑连接组图谱的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1383" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "全脑连接组、神经图谱与脑基础设施", "notes": "第 258 轮补录：全脑连接组图谱；待本地复核。；日期补齐：Crossref 2024-09-11 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-678", "title": "《Sexual coordination in a whole-brain map of prairie vole pair bonding》论文发表", "date_start": "2024-02-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕全脑连接组图谱报告或讨论可复核的学术证据。", "summary": "该节点将全脑连接组图谱的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1384" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "全脑连接组、神经图谱与脑基础设施", "notes": "第 258 轮补录：全脑连接组图谱；待本地复核。；日期补齐：Crossref 2024-02-21 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-679", "title": "《Comparative Study on Topological Properties of the Whole-Brain Functional Connectome in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease Without RBD》论文发表", "date_start": "2022-04-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕全脑连接组图谱报告或讨论可复核的学术证据。", "summary": "该节点将全脑连接组图谱的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1385" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "全脑连接组、神经图谱与脑基础设施", "notes": "第 258 轮补录：全脑连接组图谱；待本地复核。；日期补齐：Crossref 2022-04-11 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-680", "title": "《Relevance-based channel selection in motor imagery brain–computer interface》论文发表", "date_start": "2023-01-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口运动解码报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口运动解码的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1386" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、运动解码与运动功能重建", "notes": "第 259 轮补录：脑机接口运动解码；待本地复核。；日期补齐：Crossref 2023-01-23 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-681", "title": "《Decoding post-stroke motor function from structural brain images》论文发表", "date_start": "2017-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口运动解码报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口运动解码的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1387" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、运动解码与运动功能重建", "notes": "第 259 轮补录：脑机接口运动解码；待本地复核。；日期补齐：Crossref 2017-03 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-682", "title": "《Decoding motor imagery hand direction in brain computer interface from direction-dependent modulation of parietal connectivity using a new brain functional connectivity measure》论文发表", "date_start": "2025-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口运动解码报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口运动解码的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1388" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、运动解码与运动功能重建", "notes": "第 259 轮补录：脑机接口运动解码；待本地复核。；日期补齐：Crossref 2025-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-683", "title": "《Cortical brain signals improve decoding of movement and tremor for clinical brain computer interfaces》论文发表", "date_start": "2024-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口运动解码报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口运动解码的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1389" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、运动解码与运动功能重建", "notes": "第 259 轮补录：脑机接口运动解码；待本地复核。；日期补齐：Crossref 2024-01 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-684", "title": "《Improving direction decoding accuracy during online motor imagery based brain-computer interface using error-related potentials》论文发表", "date_start": "2022-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口运动解码报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口运动解码的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1390" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、运动解码与运动功能重建", "notes": "第 259 轮补录：脑机接口运动解码；待本地复核。；日期补齐：Crossref 2022-04 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-685", "title": "《Real-time brain-computer interface control of walking exoskeleton with bilateral sensory feedback》论文发表", "date_start": "2026-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口感觉反馈报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口感觉反馈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1391" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、体感反馈与闭环控制", "notes": "第 260 轮补录：脑机接口感觉反馈；待本地复核。；日期补齐：Crossref 2026-05 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-686", "title": "《A brain–computer interface working definition》论文发表", "date_start": "2025-06-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口感觉反馈报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口感觉反馈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1392" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、体感反馈与闭环控制", "notes": "第 260 轮补录：脑机接口感觉反馈；待本地复核。；日期补齐：Crossref 2025-06-02 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-687", "title": "《Peripheral nerve stimulation enables somatosensory feedback while suppressing phantom limb pain in transradial amputees》论文发表", "date_start": "2023-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口感觉反馈报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口感觉反馈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1393" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、体感反馈与闭环控制", "notes": "第 260 轮补录：脑机接口感觉反馈；待本地复核。；日期补齐：Crossref 2023-05 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-688", "title": "《Learning from feedback training data at a self-paced brain–computer interface》论文发表", "date_start": "2011-07-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口感觉反馈报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口感觉反馈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1394" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、体感反馈与闭环控制", "notes": "第 260 轮补录：脑机接口感觉反馈；待本地复核。；日期补齐：Crossref 2011-07-19 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-689", "title": "《Convolutional neural network approach for motor imagery and steady-state somatosensory evoked potential-based hybrid brain-computer interface using dry electrodes》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口感觉反馈报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口感觉反馈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1395" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑机接口、体感反馈与闭环控制", "notes": "第 260 轮补录：脑机接口感觉反馈；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-690", "title": "《Neural mechanisms underlying intracortical microstimulation for sensory restoration》论文发表", "date_start": "2026-01-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕神经假体与人工感官报告或讨论可复核的学术证据。", "summary": "该节点将神经假体与人工感官的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1396" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经假体、人工感官与感觉恢复", "notes": "第 261 轮补录：神经假体与人工感官；待本地复核。；日期补齐：Crossref 2026-01-15 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-691", "title": "《Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy》论文发表", "date_start": "2024-12-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕神经假体与人工感官报告或讨论可复核的学术证据。", "summary": "该节点将神经假体与人工感官的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1397" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经假体、人工感官与感觉恢复", "notes": "第 261 轮补录：神经假体与人工感官；待本地复核。；日期补齐：Crossref 2024-12-30 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-692", "title": "《Recapitulating sensory feedback in artificial skin》论文发表", "date_start": "2023-06-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕神经假体与人工感官报告或讨论可复核的学术证据。", "summary": "该节点将神经假体与人工感官的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1398" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经假体、人工感官与感觉恢复", "notes": "第 261 轮补录：神经假体与人工感官；待本地复核。；日期补齐：Crossref 2023-06-12 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-693", "title": "《Targeted Nipple-Areola Complex Reinnervation for Sensory Restoration in Gender-Affirming Mastectomy》论文发表", "date_start": "2024-11-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕神经假体与人工感官报告或讨论可复核的学术证据。", "summary": "该节点将神经假体与人工感官的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1399" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经假体、人工感官与感觉恢复", "notes": "第 261 轮补录：神经假体与人工感官；待本地复核。；日期补齐：Crossref 2024-11-22 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-694", "title": "《Restoration of sensory information via bionic hands》论文发表", "date_start": "2020-11-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕神经假体与人工感官报告或讨论可复核的学术证据。", "summary": "该节点将神经假体与人工感官的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1400" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经假体、人工感官与感觉恢复", "notes": "第 261 轮补录：神经假体与人工感官；待本地复核。；日期补齐：Crossref 2020-11-23 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-695", "title": "《Sleep—A brain-state serving systems memory consolidation》论文发表", "date_start": "2023-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕记忆巩固与睡眠依赖报告或讨论可复核的学术证据。", "summary": "该节点将记忆巩固与睡眠依赖的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1401" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "记忆巩固、睡眠依赖与长期记忆维护", "notes": "第 262 轮补录：记忆巩固与睡眠依赖；待本地复核。；日期补齐：Crossref 2023-04 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-696", "title": "《Smell, Sleep, and Memory Consolidation》论文发表", "date_start": "2007-03-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕记忆巩固与睡眠依赖报告或讨论可复核的学术证据。", "summary": "该节点将记忆巩固与睡眠依赖的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1402" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "记忆巩固、睡眠依赖与长期记忆维护", "notes": "第 262 轮补录：记忆巩固与睡眠依赖；待本地复核。；日期补齐：Crossref 2007-03-09 (published-print, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-697", "title": "《Sleep-dependent memory consolidation》论文发表", "date_start": "2005-10-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕记忆巩固与睡眠依赖报告或讨论可复核的学术证据。", "summary": "该节点将记忆巩固与睡眠依赖的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1403" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "记忆巩固、睡眠依赖与长期记忆维护", "notes": "第 262 轮补录：记忆巩固与睡眠依赖；待本地复核。；日期补齐：Crossref 2005-10-26 (published-online, day, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-698", "title": "《Memory Consolidation in Sleep》论文发表", "date_start": "2004-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕记忆巩固与睡眠依赖报告或讨论可复核的学术证据。", "summary": "该节点将记忆巩固与睡眠依赖的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1404" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "记忆巩固、睡眠依赖与长期记忆维护", "notes": "第 262 轮补录：记忆巩固与睡眠依赖；待本地复核。；日期补齐：Crossref 2004-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-699", "title": "《Reactivation of memory-encoding dentate gyrus neurons during memory consolidation is associated with subregion-specific, learning- and sleep-mediated biosynthetic changes》论文发表", "date_start": "2024-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕记忆巩固与睡眠依赖报告或讨论可复核的学术证据。", "summary": "该节点将记忆巩固与睡眠依赖的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1405" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "记忆巩固、睡眠依赖与长期记忆维护", "notes": "第 262 轮补录：记忆巩固与睡眠依赖；待本地复核。；日期补齐：Crossref 2024-02 (published-print, month, v3)", "created_at": "2026-08-07T06:01:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-700", "title": "《Meta-learning synaptic plasticity and memory addressing for continual familiarity detection》论文发表", "date_start": "2022-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕突触可塑性与学习报告或讨论可复核的学术证据。", "summary": "该节点将突触可塑性与学习的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1406" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "突触可塑性、学习与记忆机制", "notes": "第 263 轮补录：突触可塑性与学习；待本地复核。；日期补齐：Crossref 2022-02 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-701", "title": "《Phase-Amplitude Coupling: A General Mechanism for Memory Processing and Synaptic Plasticity?》论文发表", "date_start": "2018-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕突触可塑性与学习报告或讨论可复核的学术证据。", "summary": "该节点将突触可塑性与学习的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1407" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "突触可塑性、学习与记忆机制", "notes": "第 263 轮补录：突触可塑性与学习；待本地复核。；日期补齐：Crossref 2018-01 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-702", "title": "《Synaptic signatures of perinatal cannabinoids: A systematic review of rodent hippocampal synaptic plasticity, learning, and memory》论文发表", "date_start": "2025-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕突触可塑性与学习报告或讨论可复核的学术证据。", "summary": "该节点将突触可塑性与学习的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1408" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "突触可塑性、学习与记忆机制", "notes": "第 263 轮补录：突触可塑性与学习；待本地复核。；日期补齐：Crossref 2025-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-703", "title": "《Neuromodulators and Long-Term Synaptic Plasticity in Learning and Memory: A Steered-Glutamatergic Perspective》论文发表", "date_start": "2019-10-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕突触可塑性与学习报告或讨论可复核的学术证据。", "summary": "该节点将突触可塑性与学习的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1409" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "突触可塑性、学习与记忆机制", "notes": "第 263 轮补录：突触可塑性与学习；待本地复核。；日期补齐：Crossref 2019-10-31 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-704", "title": "《Synaptic Plasticity and Learning and Memory: 15 Years of Progress》论文发表", "date_start": "1998-07", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕突触可塑性与学习报告或讨论可复核的学术证据。", "summary": "该节点将突触可塑性与学习的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1410" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "突触可塑性、学习与记忆机制", "notes": "第 263 轮补录：突触可塑性与学习；待本地复核。；日期补齐：Crossref 1998-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-705", "title": "《The Role of Hyperbaric Oxygen Therapy in Neuroregeneration and Neuroprotection: A Review》论文发表", "date_start": "2024-06-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕神经再生药物报告或讨论可复核的学术证据。", "summary": "该节点将神经再生药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1411" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经再生、药理学干预与功能恢复", "notes": "第 264 轮补录：神经再生药物；待本地复核。；日期补齐：Crossref 2024-06-10 (published-print, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-706", "title": "《Neuroregeneration and functional recovery after stroke: advancing neural stem cell therapy toward clinical application》论文发表", "date_start": "2021", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕神经再生药物报告或讨论可复核的学术证据。", "summary": "该节点将神经再生药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1412" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经再生、药理学干预与功能恢复", "notes": "第 264 轮补录：神经再生药物；待本地复核。；日期补齐：Crossref 2021 (published-print, year, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-707", "title": "《The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs》论文发表", "date_start": "2018", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕神经再生药物报告或讨论可复核的学术证据。", "summary": "该节点将神经再生药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1413" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经再生、药理学干预与功能恢复", "notes": "第 264 轮补录：神经再生药物；待本地复核。；日期补齐：Crossref 2018 (published-print, year, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-708", "title": "《TRPV1 may increase the effectiveness of estrogen therapy on neuroprotection and neuroregeneration》论文发表", "date_start": "2016", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕神经再生药物报告或讨论可复核的学术证据。", "summary": "该节点将神经再生药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1414" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经再生、药理学干预与功能恢复", "notes": "第 264 轮补录：神经再生药物；待本地复核。；日期补齐：Crossref 2016 (published-print, year, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-709", "title": "《Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen therapy enhance neuroregeneration in a rat model of sciatic nerve crush injury》论文发表", "date_start": "2025-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕神经再生药物报告或讨论可复核的学术证据。", "summary": "该节点将神经再生药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1415" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经再生、药理学干预与功能恢复", "notes": "第 264 轮补录：神经再生药物；待本地复核。；日期补齐：Crossref 2025-03 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-710", "title": "《Cognitive Reserve and Related Constructs: A Unified Framework Across Cognitive and Brain Dimensions of Aging》论文发表", "date_start": "2022-05-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脑衰老与认知储备报告或讨论可复核的学术证据。", "summary": "该节点将脑衰老与认知储备的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1416" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑衰老、认知储备与脑韧性", "notes": "第 265 轮补录：脑衰老与认知储备；待本地复核。；日期补齐：Crossref 2022-05-27 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-711", "title": "《The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer’s Disease》论文发表", "date_start": "2019-03-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脑衰老与认知储备报告或讨论可复核的学术证据。", "summary": "该节点将脑衰老与认知储备的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1417" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑衰老、认知储备与脑韧性", "notes": "第 265 轮补录：脑衰老与认知储备；待本地复核。；日期补齐：Crossref 2019-03-06 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-712", "title": "《Lower cognitive reserve in the aging human immunodeficiency virus-infected brain》论文发表", "date_start": "2013-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脑衰老与认知储备报告或讨论可复核的学术证据。", "summary": "该节点将脑衰老与认知储备的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1418" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑衰老、认知储备与脑韧性", "notes": "第 265 轮补录：脑衰老与认知储备；待本地复核。；日期补齐：Crossref 2013-04 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-713", "title": "《Brain structure and function related to cognitive reserve variables in normal aging, mild cognitive impairment and Alzheimer's disease》论文发表", "date_start": "2009-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脑衰老与认知储备报告或讨论可复核的学术证据。", "summary": "该节点将脑衰老与认知储备的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1419" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑衰老、认知储备与脑韧性", "notes": "第 265 轮补录：脑衰老与认知储备；待本地复核。；日期补齐：Crossref 2009-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-714", "title": "《Cognitive reserve and brain maintenance in aging and dementia: An integrative review》论文发表", "date_start": "2021-01-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脑衰老与认知储备报告或讨论可复核的学术证据。", "summary": "该节点将脑衰老与认知储备的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1420" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑衰老、认知储备与脑韧性", "notes": "第 265 轮补录：脑衰老与认知储备；待本地复核。；日期补齐：Crossref 2021-01-25 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-715", "title": "《Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?》论文发表", "date_start": "2025-03-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与动脉硬化逆转报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与动脉硬化逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1421" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管衰老、动脉硬化与血管韧性", "notes": "第 266 轮补录：心血管衰老与动脉硬化逆转；待本地复核。；日期补齐：Crossref 2025-03-21 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-716", "title": "《Vascular Aging and Atherosclerosis: A Perspective on Aging》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与动脉硬化逆转报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与动脉硬化逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1422" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管衰老、动脉硬化与血管韧性", "notes": "第 266 轮补录：心血管衰老与动脉硬化逆转；待本地复核。；日期补齐：Crossref 2025 (published-print, year, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-717", "title": "《The Role and Mechanism of Vascular Aging in Geriatric Vascular Diseases》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与动脉硬化逆转报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与动脉硬化逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1423" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管衰老、动脉硬化与血管韧性", "notes": "第 266 轮补录：心血管衰老与动脉硬化逆转；待本地复核。；日期补齐：Crossref 2024 (published-online, year, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-718", "title": "《Cerebral Hemodynamics and Carotid Atherosclerosis in Patients With Subcortical Ischemic Vascular Dementia》论文发表", "date_start": "2021-11-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与动脉硬化逆转报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与动脉硬化逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1424" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管衰老、动脉硬化与血管韧性", "notes": "第 266 轮补录：心血管衰老与动脉硬化逆转；待本地复核。；日期补齐：Crossref 2021-11-22 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-719", "title": "《MicroRNAs in vascular aging and atherosclerosis》论文发表", "date_start": "2014-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与动脉硬化逆转报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与动脉硬化逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1425" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心血管衰老、动脉硬化与血管韧性", "notes": "第 266 轮补录：心血管衰老与动脉硬化逆转；待本地复核。；日期补齐：Crossref 2014-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-720", "title": "《Enhanced angiogenesis through controlled release of basic fibroblast growth factor from peptide amphiphile for tissue regeneration》论文发表", "date_start": "2006-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕血管新生与组织灌注报告或讨论可复核的学术证据。", "summary": "该节点将血管新生与组织灌注的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1426" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "血管新生、组织灌注与缺血修复", "notes": "第 267 轮补录：血管新生与组织灌注；待本地复核。；日期补齐：Crossref 2006-12 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-721", "title": "《Hyperbaric oxygen therapy promotes wound repair in ischemic and hyperglycemic conditions, increasing tissue perfusion and collagen deposition》论文发表", "date_start": "2016-10-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕血管新生与组织灌注报告或讨论可复核的学术证据。", "summary": "该节点将血管新生与组织灌注的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1427" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "血管新生、组织灌注与缺血修复", "notes": "第 267 轮补录：血管新生与组织灌注；待本地复核。；日期补齐：Crossref 2016-10-18 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-722", "title": "《Microvessels derived from hiPSCs are a novel source for angiogenesis and tissue regeneration》论文发表", "date_start": "2022-12-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕血管新生与组织灌注报告或讨论可复核的学术证据。", "summary": "该节点将血管新生与组织灌注的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1428" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "血管新生、组织灌注与缺血修复", "notes": "第 267 轮补录：血管新生与组织灌注；待本地复核。；日期补齐：Crossref 2022-12-26 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-723", "title": "《Trimetazidine improves angiogenesis and tissue perfusion in ischemic rat skeletal muscle》论文发表", "date_start": "2024-07-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕血管新生与组织灌注报告或讨论可复核的学术证据。", "summary": "该节点将血管新生与组织灌注的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1429" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "血管新生、组织灌注与缺血修复", "notes": "第 267 轮补录：血管新生与组织灌注；待本地复核。；日期补齐：Crossref 2024-07-23 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-724", "title": "《Novel metal nanomaterials to promote angiogenesis in tissue regeneration》论文发表", "date_start": "2023-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕血管新生与组织灌注报告或讨论可复核的学术证据。", "summary": "该节点将血管新生与组织灌注的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1430" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "血管新生、组织灌注与缺血修复", "notes": "第 267 轮补录：血管新生与组织灌注；待本地复核。；日期补齐：Crossref 2023-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-725", "title": "《Lymphatic-immune interactions in the musculoskeletal system》论文发表", "date_start": "2025-05-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕淋巴系统与免疫运输报告或讨论可复核的学术证据。", "summary": "该节点将淋巴系统与免疫运输的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1431" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "淋巴系统、免疫运输与组织稳态", "notes": "第 268 轮补录：淋巴系统与免疫运输；待本地复核。；日期补齐：Crossref 2025-05-27 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-726", "title": "《Immune cells as messengers from the CNS to the periphery: the role of the meningeal lymphatic system in immune cell migration from the CNS》论文发表", "date_start": "2023-08-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕淋巴系统与免疫运输报告或讨论可复核的学术证据。", "summary": "该节点将淋巴系统与免疫运输的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1432" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "淋巴系统、免疫运输与组织稳态", "notes": "第 268 轮补录：淋巴系统与免疫运输；待本地复核。；日期补齐：Crossref 2023-08-17 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-727", "title": "《Leucocyte Trafficking via the Lymphatic Vasculature— Mechanisms and Consequences》论文发表", "date_start": "2019-03-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕淋巴系统与免疫运输报告或讨论可复核的学术证据。", "summary": "该节点将淋巴系统与免疫运输的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1433" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "淋巴系统、免疫运输与组织稳态", "notes": "第 268 轮补录：淋巴系统与免疫运输；待本地复核。；日期补齐：Crossref 2019-03-14 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-728", "title": "《Regulation of Immune Function by the Lymphatic System in Lymphedema》论文发表", "date_start": "2019-03-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕淋巴系统与免疫运输报告或讨论可复核的学术证据。", "summary": "该节点将淋巴系统与免疫运输的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1434" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "淋巴系统、免疫运输与组织稳态", "notes": "第 268 轮补录：淋巴系统与免疫运输；待本地复核。；日期补齐：Crossref 2019-03-18 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-729", "title": "《T Cell Trafficking through Lymphatic Vessels》论文发表", "date_start": "2016-12-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕淋巴系统与免疫运输报告或讨论可复核的学术证据。", "summary": "该节点将淋巴系统与免疫运输的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1435" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "淋巴系统、免疫运输与组织稳态", "notes": "第 268 轮补录：淋巴系统与免疫运输；待本地复核。；日期补齐：Crossref 2016-12-21 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-730", "title": "《Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways》论文发表", "date_start": "2026-05-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕免疫衰老与疫苗反应报告或讨论可复核的学术证据。", "summary": "该节点将免疫衰老与疫苗反应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1436" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫衰老、疫苗反应与免疫韧性", "notes": "第 269 轮补录：免疫衰老与疫苗反应；待本地复核。；日期补齐：Crossref 2026-05-22 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-731", "title": "《Immunosenescence and vaccine efficacy revealed by immunometabolic analysis of SARS-CoV-2-specific cells in multiple sclerosis patients》论文发表", "date_start": "2024-03-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕免疫衰老与疫苗反应报告或讨论可复核的学术证据。", "summary": "该节点将免疫衰老与疫苗反应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1437" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫衰老、疫苗反应与免疫韧性", "notes": "第 269 轮补录：免疫衰老与疫苗反应；待本地复核。；日期补齐：Crossref 2024-03-29 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-732", "title": "《Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response》论文发表", "date_start": "2020-08-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕免疫衰老与疫苗反应报告或讨论可复核的学术证据。", "summary": "该节点将免疫衰老与疫苗反应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1438" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫衰老、疫苗反应与免疫韧性", "notes": "第 269 轮补录：免疫衰老与疫苗反应；待本地复核。；日期补齐：Crossref 2020-08-07 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-733", "title": "《Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly》论文发表", "date_start": "2020-10-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕免疫衰老与疫苗反应报告或讨论可复核的学术证据。", "summary": "该节点将免疫衰老与疫苗反应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1439" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫衰老、疫苗反应与免疫韧性", "notes": "第 269 轮补录：免疫衰老与疫苗反应；待本地复核。；日期补齐：Crossref 2020-10-14 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-734", "title": "《Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses》论文发表", "date_start": "2019-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕免疫衰老与疫苗反应报告或讨论可复核的学术证据。", "summary": "该节点将免疫衰老与疫苗反应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1440" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫衰老、疫苗反应与免疫韧性", "notes": "第 269 轮补录：免疫衰老与疫苗反应；待本地复核。；日期补齐：Crossref 2019-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-735", "title": "《Single Cell and Spatially Resolved Transcriptome and Immune Repertoire of Mouse Thymus During Aging Reveal Immunological Heterogeneity and Direction of Thymic Selection Pressure》论文发表", "date_start": "2026-07-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕胸腺再生与T细胞库报告或讨论可复核的学术证据。", "summary": "该节点将胸腺再生与T细胞库的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1441" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胸腺再生、T细胞库与免疫重建", "notes": "第 270 轮补录：胸腺再生与T细胞库；待本地复核。；日期补齐：Crossref 2026-07-25 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-736", "title": "《Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity》论文发表", "date_start": "2025-10-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕胸腺再生与T细胞库报告或讨论可复核的学术证据。", "summary": "该节点将胸腺再生与T细胞库的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1442" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胸腺再生、T细胞库与免疫重建", "notes": "第 270 轮补录：胸腺再生与T细胞库；待本地复核。；日期补齐：Crossref 2025-10-30 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-737", "title": "《Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regeneration》论文发表", "date_start": "2023-11-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕胸腺再生与T细胞库报告或讨论可复核的学术证据。", "summary": "该节点将胸腺再生与T细胞库的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1443" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胸腺再生、T细胞库与免疫重建", "notes": "第 270 轮补录：胸腺再生与T细胞库；待本地复核。；日期补齐：Crossref 2023-11-08 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-738", "title": "《Regeneration circuits in the thymus》论文发表", "date_start": "2018-01-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕胸腺再生与T细胞库报告或讨论可复核的学术证据。", "summary": "该节点将胸腺再生与T细胞库的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1444" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胸腺再生、T细胞库与免疫重建", "notes": "第 270 轮补录：胸腺再生与T细胞库；待本地复核。；日期补齐：Crossref 2018-01-18 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-739", "title": "《Human T cell repertoire: what happens in thymus does not stay in thymus》论文发表", "date_start": "2019-05-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕胸腺再生与T细胞库报告或讨论可复核的学术证据。", "summary": "该节点将胸腺再生与T细胞库的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1445" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胸腺再生、T细胞库与免疫重建", "notes": "第 270 轮补录：胸腺再生与T细胞库；待本地复核。；日期补齐：Crossref 2019-05-13 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-740", "title": "《Aging of hematopoietic stem cells is inconsequential to progenitor cell function》论文发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕造血系统衰老报告或讨论可复核的学术证据。", "summary": "该节点将造血系统衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1446" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "造血系统衰老、血细胞更新与血液韧性", "notes": "第 271 轮补录：造血系统衰老；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-741", "title": "《Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging》论文发表", "date_start": "2025-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕造血系统衰老报告或讨论可复核的学术证据。", "summary": "该节点将造血系统衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1447" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "造血系统衰老、血细胞更新与血液韧性", "notes": "第 271 轮补录：造血系统衰老；待本地复核。；日期补齐：Crossref 2025-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-742", "title": "《DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress》论文发表", "date_start": "2024-10-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕造血系统衰老报告或讨论可复核的学术证据。", "summary": "该节点将造血系统衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1448" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "造血系统衰老、血细胞更新与血液韧性", "notes": "第 271 轮补录：造血系统衰老；待本地复核。；日期补齐：Crossref 2024-10-11 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-743", "title": "《Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells》论文发表", "date_start": "2022-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕造血系统衰老报告或讨论可复核的学术证据。", "summary": "该节点将造血系统衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1449" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "造血系统衰老、血细胞更新与血液韧性", "notes": "第 271 轮补录：造血系统衰老；待本地复核。；日期补齐：Crossref 2022-08 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-744", "title": "《Aging of the Hematopoietic Stem Cell Niche: An Unnerving Matter》论文发表", "date_start": "2019-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕造血系统衰老报告或讨论可复核的学术证据。", "summary": "该节点将造血系统衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1450" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "造血系统衰老、血细胞更新与血液韧性", "notes": "第 271 轮补录：造血系统衰老；待本地复核。；日期补齐：Crossref 2019-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-745", "title": "《Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering》论文发表", "date_start": "2025-10-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕干细胞生态位工程报告或讨论可复核的学术证据。", "summary": "该节点将干细胞生态位工程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1451" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞生态位、工程化微环境与再生", "notes": "第 272 轮补录：干细胞生态位工程；待本地复核。；日期补齐：Crossref 2025-10-28 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-746", "title": "《The emergence of the stem cell niche》论文发表", "date_start": "2023-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕干细胞生态位工程报告或讨论可复核的学术证据。", "summary": "该节点将干细胞生态位工程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1452" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞生态位、工程化微环境与再生", "notes": "第 272 轮补录：干细胞生态位工程；待本地复核。；日期补齐：Crossref 2023-02 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-747", "title": "《The intestinal stem cell niche flexes its muscles》论文发表", "date_start": "2023-04-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕干细胞生态位工程报告或讨论可复核的学术证据。", "summary": "该节点将干细胞生态位工程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1453" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞生态位、工程化微环境与再生", "notes": "第 272 轮补录：干细胞生态位工程；待本地复核。；日期补齐：Crossref 2023-04-05 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-748", "title": "《Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress》论文发表", "date_start": "2024-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕干细胞生态位工程报告或讨论可复核的学术证据。", "summary": "该节点将干细胞生态位工程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1454" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞生态位、工程化微环境与再生", "notes": "第 272 轮补录：干细胞生态位工程；待本地复核。；日期补齐：Crossref 2024-01 (published-print, month, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-749", "title": "《Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell–Matrix Interface》论文发表", "date_start": "2015-07-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕干细胞生态位工程报告或讨论可复核的学术证据。", "summary": "该节点将干细胞生态位工程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1455" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "干细胞生态位、工程化微环境与再生", "notes": "第 272 轮补录：干细胞生态位工程；待本地复核。；日期补齐：Crossref 2015-07-29 (published-online, day, v3)", "created_at": "2026-08-07T06:01:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-750", "title": "《Polyphenol mediated zinc-oxygen synergistic hydrogel remodels senescent microenvironment for periodontal tissue regeneration》论文发表", "date_start": "2026-03-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞衰老与组织微环境报告或讨论可复核的学术证据。", "summary": "该节点将细胞衰老与组织微环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1456" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、组织微环境与慢性炎症", "notes": "第 273 轮补录：细胞衰老与组织微环境；待本地复核。；日期补齐：Crossref 2026-03-10 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-751", "title": "《The impact of the senescent microenvironment on tumorigenesis: Insights for cancer therapy》论文发表", "date_start": "2024-04-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞衰老与组织微环境报告或讨论可复核的学术证据。", "summary": "该节点将细胞衰老与组织微环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1457" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、组织微环境与慢性炎症", "notes": "第 273 轮补录：细胞衰老与组织微环境；待本地复核。；日期补齐：Crossref 2024-04-22 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-752", "title": "《Fundamental Cell-Intrinsic Mechanism Underlying Age-Dependent Accumulation of Senescent Cells》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞衰老与组织微环境报告或讨论可复核的学术证据。", "summary": "该节点将细胞衰老与组织微环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1458" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、组织微环境与慢性炎症", "notes": "第 273 轮补录：细胞衰老与组织微环境；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-753", "title": "《Microenvironment-sensitive nanozymes for tissue regeneration》论文发表", "date_start": "2024-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞衰老与组织微环境报告或讨论可复核的学术证据。", "summary": "该节点将细胞衰老与组织微环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1459" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、组织微环境与慢性炎症", "notes": "第 273 轮补录：细胞衰老与组织微环境；待本地复核。；日期补齐：Crossref 2024-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-754", "title": "《Senescent cells enhance newt limb regeneration by promoting muscle dedifferentiation》论文发表", "date_start": "2023-04-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞衰老与组织微环境报告或讨论可复核的学术证据。", "summary": "该节点将细胞衰老与组织微环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1460" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、组织微环境与慢性炎症", "notes": "第 273 轮补录：细胞衰老与组织微环境；待本地复核。；日期补齐：Crossref 2023-04-06 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-755", "title": "《The senescence-stiffening loop: Extracellular matrix remodeling, hypoperfusion, and mitochondrial dysfunction drive tissue aging》论文发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞外基质重塑报告或讨论可复核的学术证据。", "summary": "该节点将细胞外基质重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1461" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞外基质、组织重塑与纤维化", "notes": "第 274 轮补录：细胞外基质重塑；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-756", "title": "《Extracellular matrix remodeling in the tumor immunity》论文发表", "date_start": "2024-01-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞外基质重塑报告或讨论可复核的学术证据。", "summary": "该节点将细胞外基质重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1462" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞外基质、组织重塑与纤维化", "notes": "第 274 轮补录：细胞外基质重塑；待本地复核。；日期补齐：Crossref 2024-01-25 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-757", "title": "《Counteracting immunodepression by extracellular matrix hydrogel to promote brain tissue remodeling and neurological function recovery after traumatic brain injury》论文发表", "date_start": "2025-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞外基质重塑报告或讨论可复核的学术证据。", "summary": "该节点将细胞外基质重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1463" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞外基质、组织重塑与纤维化", "notes": "第 274 轮补录：细胞外基质重塑；待本地复核。；日期补齐：Crossref 2025-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-758", "title": "《Alpha-1 adrenergic signaling drives cardiac regeneration via extracellular matrix remodeling transcriptional program in zebrafish macrophages》论文发表", "date_start": "2023-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞外基质重塑报告或讨论可复核的学术证据。", "summary": "该节点将细胞外基质重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1464" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞外基质、组织重塑与纤维化", "notes": "第 274 轮补录：细胞外基质重塑；待本地复核。；日期补齐：Crossref 2023-11 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-759", "title": "《Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation》论文发表", "date_start": "2019-07-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞外基质重塑报告或讨论可复核的学术证据。", "summary": "该节点将细胞外基质重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1465" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞外基质、组织重塑与纤维化", "notes": "第 274 轮补录：细胞外基质重塑；待本地复核。；日期补齐：Crossref 2019-07-26 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-760", "title": "《Brain senescence drives sarcopenia-like transcriptomic remodeling in skeletal muscle》论文发表", "date_start": "2026-05-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肌肉再生与肌少症逆转报告或讨论可复核的学术证据。", "summary": "该节点将肌肉再生与肌少症逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1466" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼肌、肌少症与肌肉再生", "notes": "第 275 轮补录：肌肉再生与肌少症逆转；待本地复核。；日期补齐：Crossref 2026-05-14 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-761", "title": "《Macrophage SREBP1 regulates skeletal muscle regeneration》论文发表", "date_start": "2024-01-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肌肉再生与肌少症逆转报告或讨论可复核的学术证据。", "summary": "该节点将肌肉再生与肌少症逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1467" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼肌、肌少症与肌肉再生", "notes": "第 275 轮补录：肌肉再生与肌少症逆转；待本地复核。；日期补齐：Crossref 2024-01-08 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-762", "title": "《Skeletal Muscle Regeneration: Functional Skeletal Muscle Regeneration with Thermally Drawn Porous Fibers and Reprogrammed Muscle Progenitors for Volumetric Muscle Injury (Adv. Mater. 14/2021)》论文发表", "date_start": "2021-04-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肌肉再生与肌少症逆转报告或讨论可复核的学术证据。", "summary": "该节点将肌肉再生与肌少症逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1468" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼肌、肌少症与肌肉再生", "notes": "第 275 轮补录：肌肉再生与肌少症逆转；待本地复核。；日期补齐：Crossref 2021-04-07 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-763", "title": "《SRSF1 Is Crucial for Maintaining Satellite Cell Homeostasis During Skeletal Muscle Growth and Regeneration》论文发表", "date_start": "2024-10-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肌肉再生与肌少症逆转报告或讨论可复核的学术证据。", "summary": "该节点将肌肉再生与肌少症逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1469" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼肌、肌少症与肌肉再生", "notes": "第 275 轮补录：肌肉再生与肌少症逆转；待本地复核。；日期补齐：Crossref 2024-10-09 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-764", "title": "《Old muscle stem cells are rejuvenated by a young environment》论文发表", "date_start": "2023-03-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肌肉再生与肌少症逆转报告或讨论可复核的学术证据。", "summary": "该节点将肌肉再生与肌少症逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1470" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼肌、肌少症与肌肉再生", "notes": "第 275 轮补录：肌肉再生与肌少症逆转；待本地复核。；日期补齐：Crossref 2023-03-06 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-765", "title": "《Osteoporosis: interferon-gamma-mediated bone remodeling in osteoimmunology》论文发表", "date_start": "2024-05-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕骨骼重塑与骨质疏松报告或讨论可复核的学术证据。", "summary": "该节点将骨骼重塑与骨质疏松的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1471" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼重塑、骨质疏松与骨骼韧性", "notes": "第 276 轮补录：骨骼重塑与骨质疏松；待本地复核。；日期补齐：Crossref 2024-05-16 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-766", "title": "《Bone remodeling: A review of the bone microenvironment perspective for fragility fracture (osteoporosis) of the hip》论文发表", "date_start": "2008-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕骨骼重塑与骨质疏松报告或讨论可复核的学术证据。", "summary": "该节点将骨骼重塑与骨质疏松的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1472" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼重塑、骨质疏松与骨骼韧性", "notes": "第 276 轮补录：骨骼重塑与骨质疏松；待本地复核。；日期补齐：Crossref 2008-10 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-767", "title": "《Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis》论文发表", "date_start": "2023-06-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕骨骼重塑与骨质疏松报告或讨论可复核的学术证据。", "summary": "该节点将骨骼重塑与骨质疏松的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1473" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼重塑、骨质疏松与骨骼韧性", "notes": "第 276 轮补录：骨骼重塑与骨质疏松；待本地复核。；日期补齐：Crossref 2023-06-09 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-768", "title": "《Epigenetics, Bone Remodeling and Osteoporosis》论文发表", "date_start": "2018-01-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕骨骼重塑与骨质疏松报告或讨论可复核的学术证据。", "summary": "该节点将骨骼重塑与骨质疏松的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1474" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼重塑、骨质疏松与骨骼韧性", "notes": "第 276 轮补录：骨骼重塑与骨质疏松；待本地复核。；日期补齐：Crossref 2018-01-19 (published-print, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-769", "title": "《Clinical use of biochemical markers of bone remodeling in osteoporosis》论文发表", "date_start": "1992", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕骨骼重塑与骨质疏松报告或讨论可复核的学术证据。", "summary": "该节点将骨骼重塑与骨质疏松的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1475" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "骨骼重塑、骨质疏松与骨骼韧性", "notes": "第 276 轮补录：骨骼重塑与骨质疏松；待本地复核。；日期补齐：Crossref 1992 (published-print, year, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-770", "title": "《From fat to fate: how aging adipose tissue drives systemic metabolic aging》论文发表", "date_start": "2025-12-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脂肪组织与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将脂肪组织与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1476" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脂肪组织、代谢健康与衰老", "notes": "第 277 轮补录：脂肪组织与代谢健康；待本地复核。；日期补齐：Crossref 2025-12-27 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-771", "title": "《IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline》论文发表", "date_start": "2024-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脂肪组织与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将脂肪组织与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1477" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脂肪组织、代谢健康与衰老", "notes": "第 277 轮补录：脂肪组织与代谢健康；待本地复核。；日期补齐：Crossref 2024-04 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-772", "title": "《Exploring adipose tissue-derived extracellular vesicles in inter-organ crosstalk: Implications for metabolic regulation and adipose tissue function》论文发表", "date_start": "2025-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脂肪组织与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将脂肪组织与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1478" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脂肪组织、代谢健康与衰老", "notes": "第 277 轮补录：脂肪组织与代谢健康；待本地复核。；日期补齐：Crossref 2025-06 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-773", "title": "《The interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health》论文发表", "date_start": "2024-01-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脂肪组织与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将脂肪组织与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1479" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脂肪组织、代谢健康与衰老", "notes": "第 277 轮补录：脂肪组织与代谢健康；待本地复核。；日期补齐：Crossref 2024-01-08 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-774", "title": "《It is a branched road to adipose tissue aging》论文发表", "date_start": "2023-07-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脂肪组织与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将脂肪组织与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1480" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脂肪组织、代谢健康与衰老", "notes": "第 277 轮补录：脂肪组织与代谢健康；待本地复核。；日期补齐：Crossref 2023-07-24 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-775", "title": "《Beta-Cell Dedifferentiation in Type 2 Diabetes: Concise Review》论文发表", "date_start": "2019-07-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胰岛β细胞再生报告或讨论可复核的学术证据。", "summary": "该节点将胰岛β细胞再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1481" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胰岛β细胞、糖尿病逆转与内分泌再生", "notes": "第 278 轮补录：胰岛β细胞再生；待本地复核。；日期补齐：Crossref 2019-07-31 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-776", "title": "《Beta-cell replacement and regeneration: Strategies of cell-based therapy for type 1 diabetes mellitus》论文发表", "date_start": "2008-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胰岛β细胞再生报告或讨论可复核的学术证据。", "summary": "该节点将胰岛β细胞再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1482" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胰岛β细胞、糖尿病逆转与内分泌再生", "notes": "第 278 轮补录：胰岛β细胞再生；待本地复核。；日期补齐：Crossref 2008-03 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-777", "title": "《Regeneration of pancreatic beta-cell mass for the treatment of diabetes》论文发表", "date_start": "2012-04-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胰岛β细胞再生报告或讨论可复核的学术证据。", "summary": "该节点将胰岛β细胞再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1483" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胰岛β细胞、糖尿病逆转与内分泌再生", "notes": "第 278 轮补录：胰岛β细胞再生；待本地复核。；日期补齐：Crossref 2012-04-16 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-778", "title": "《From pancreatic islet formation to beta-cell regeneration》论文发表", "date_start": "2013-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胰岛β细胞再生报告或讨论可复核的学术证据。", "summary": "该节点将胰岛β细胞再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1484" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胰岛β细胞、糖尿病逆转与内分泌再生", "notes": "第 278 轮补录：胰岛β细胞再生；待本地复核。；日期补齐：Crossref 2013-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-779", "title": "《Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?》论文发表", "date_start": "2005-10-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕胰岛β细胞再生报告或讨论可复核的学术证据。", "summary": "该节点将胰岛β细胞再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1485" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "胰岛β细胞、糖尿病逆转与内分泌再生", "notes": "第 278 轮补录：胰岛β细胞再生；待本地复核。；日期补齐：Crossref 2005-10-05 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-780", "title": "《Metabolic Dysfunction-Associated Steatotic Liver Disease: The Role of Hepatic Steatosis in Insulin Resistance and Metabolic Health》论文发表", "date_start": "2025-04-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肝脏脂肪变性逆转报告或讨论可复核的学术证据。", "summary": "该节点将肝脏脂肪变性逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1486" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肝脏脂肪变性、代谢逆转与肝脏健康", "notes": "第 279 轮补录：肝脏脂肪变性逆转；待本地复核。；日期补齐：Crossref 2025-04-30 (published-print, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-781", "title": "《The mediterranean diet, hepatic steatosis and nonalcoholic fatty liver disease》论文发表", "date_start": "2014-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肝脏脂肪变性逆转报告或讨论可复核的学术证据。", "summary": "该节点将肝脏脂肪变性逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1487" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肝脏脂肪变性、代谢逆转与肝脏健康", "notes": "第 279 轮补录：肝脏脂肪变性逆转；待本地复核。；日期补齐：Crossref 2014-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-782", "title": "《Optimal Cutoffs of Fatty Liver Index and Hepatic Steatosis Index in Diagnosing Pediatric Metabolic Dysfunction-associated Steatotic Liver Disease》论文发表", "date_start": "2026-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肝脏脂肪变性逆转报告或讨论可复核的学术证据。", "summary": "该节点将肝脏脂肪变性逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1488" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肝脏脂肪变性、代谢逆转与肝脏健康", "notes": "第 279 轮补录：肝脏脂肪变性逆转；待本地复核。；日期补齐：Crossref 2026-02 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-783", "title": "《Predicting hepatic steatosis degree in metabolic dysfunction-associated steatotic liver disease using obesity and lipid-related indices》论文发表", "date_start": "2025-03-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肝脏脂肪变性逆转报告或讨论可复核的学术证据。", "summary": "该节点将肝脏脂肪变性逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1489" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肝脏脂肪变性、代谢逆转与肝脏健康", "notes": "第 279 轮补录：肝脏脂肪变性逆转；待本地复核。；日期补齐：Crossref 2025-03-12 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-784", "title": "《An umbrella meta-analysis of microbial therapy on hepatic steatosis, fibrosis, and liver stiffness in metabolic dysfunction-associated steatotic liver disease》论文发表", "date_start": "2025-11-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肝脏脂肪变性逆转报告或讨论可复核的学术证据。", "summary": "该节点将肝脏脂肪变性逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1490" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肝脏脂肪变性、代谢逆转与肝脏健康", "notes": "第 279 轮补录：肝脏脂肪变性逆转；待本地复核。；日期补齐：Crossref 2025-11-25 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-785", "title": "《Effects of cassava polysaccharides on gut microbiome, intestinal barrier and macrophage activation》论文发表", "date_start": "2026-07-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肠道屏障与菌群移植报告或讨论可复核的学术证据。", "summary": "该节点将肠道屏障与菌群移植的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1491" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肠道屏障、菌群移植与微生物生态", "notes": "第 280 轮补录：肠道屏障与菌群移植；待本地复核。；日期补齐：Crossref 2026-07-02 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-786", "title": "《Gut microbiome alterations precede graft rejection in kidney transplantation patients》论文发表", "date_start": "2025-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肠道屏障与菌群移植报告或讨论可复核的学术证据。", "summary": "该节点将肠道屏障与菌群移植的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1492" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肠道屏障、菌群移植与微生物生态", "notes": "第 280 轮补录：肠道屏障与菌群移植；待本地复核。；日期补齐：Crossref 2025-08 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-787", "title": "《Rewiring bugs: Diet, the gut microbiome, and nerve regeneration》论文发表", "date_start": "2022-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肠道屏障与菌群移植报告或讨论可复核的学术证据。", "summary": "该节点将肠道屏障与菌群移植的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1493" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肠道屏障、菌群移植与微生物生态", "notes": "第 280 轮补录：肠道屏障与菌群移植；待本地复核。；日期补齐：Crossref 2022-08 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-788", "title": "《Continuous fermentation-derived fecal microbiota transplantation improves intestinal barrier function and reshapes gut microbiota in weaned piglets》论文发表", "date_start": "2026-07-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肠道屏障与菌群移植报告或讨论可复核的学术证据。", "summary": "该节点将肠道屏障与菌群移植的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1494" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肠道屏障、菌群移植与微生物生态", "notes": "第 280 轮补录：肠道屏障与菌群移植；待本地复核。；日期补齐：Crossref 2026-07-27 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-789", "title": "《Fecal Microbiota Transplantation Induces Sustained Gut Microbiome Changes in Pediatric Ulcerative Colitis: A Combined Randomized and Open-Label Study》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肠道屏障与菌群移植报告或讨论可复核的学术证据。", "summary": "该节点将肠道屏障与菌群移植的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1495" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肠道屏障、菌群移植与微生物生态", "notes": "第 280 轮补录：肠道屏障与菌群移植；待本地复核。；日期补齐：Crossref 2025 (published-print, year, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-790", "title": "《Native T1 mapping-based radiomics diagnosis of kidney function and renal fibrosis in chronic kidney disease》论文发表", "date_start": "2024-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肾脏纤维化逆转报告或讨论可复核的学术证据。", "summary": "该节点将肾脏纤维化逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1496" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏纤维化、逆转机制与肾功能保护", "notes": "第 281 轮补录：肾脏纤维化逆转；待本地复核。；日期补齐：Crossref 2024-08 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-791", "title": "《MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease》论文发表", "date_start": "2023-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肾脏纤维化逆转报告或讨论可复核的学术证据。", "summary": "该节点将肾脏纤维化逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1497" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏纤维化、逆转机制与肾功能保护", "notes": "第 281 轮补录：肾脏纤维化逆转；待本地复核。；日期补齐：Crossref 2023-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-792", "title": "《Anthraquinones from Rheum officinale Ameliorate Renal Fibrosis in Acute Kidney Injury and Chronic Kidney Disease》论文发表", "date_start": "2025-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肾脏纤维化逆转报告或讨论可复核的学术证据。", "summary": "该节点将肾脏纤维化逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1498" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏纤维化、逆转机制与肾功能保护", "notes": "第 281 轮补录：肾脏纤维化逆转；待本地复核。；日期补齐：Crossref 2025-07 (published-online, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-793", "title": "《Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy》论文发表", "date_start": "2022-07-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肾脏纤维化逆转报告或讨论可复核的学术证据。", "summary": "该节点将肾脏纤维化逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1499" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏纤维化、逆转机制与肾功能保护", "notes": "第 281 轮补录：肾脏纤维化逆转；待本地复核。；日期补齐：Crossref 2022-07-13 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-794", "title": "《Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence》论文发表", "date_start": "2020-12-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肾脏纤维化逆转报告或讨论可复核的学术证据。", "summary": "该节点将肾脏纤维化逆转的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1500" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏纤维化、逆转机制与肾功能保护", "notes": "第 281 轮补录：肾脏纤维化逆转；待本地复核。；日期补齐：Crossref 2020-12-24 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-795", "title": "《Atg5 deficiency alters myofibroblast accumulation and alveolar regeneration in lung fibrosis》论文发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肺纤维化与肺泡再生报告或讨论可复核的学术证据。", "summary": "该节点将肺纤维化与肺泡再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1501" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肺纤维化、肺泡再生与呼吸修复", "notes": "第 282 轮补录：肺纤维化与肺泡再生；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-796", "title": "《Designer umbilical cord-stem cells induce alveolar wall regeneration in pulmonary disease models》论文发表", "date_start": "2024-04-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肺纤维化与肺泡再生报告或讨论可复核的学术证据。", "summary": "该节点将肺纤维化与肺泡再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1502" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肺纤维化、肺泡再生与呼吸修复", "notes": "第 282 轮补录：肺纤维化与肺泡再生；待本地复核。；日期补齐：Crossref 2024-04-30 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-797", "title": "《Pulmonary administration of 1,25-dihydroxyvitamin D3 to the lungs induces alveolar regeneration in a mouse model of chronic obstructive pulmonary disease》论文发表", "date_start": "2016-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肺纤维化与肺泡再生报告或讨论可复核的学术证据。", "summary": "该节点将肺纤维化与肺泡再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1503" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肺纤维化、肺泡再生与呼吸修复", "notes": "第 282 轮补录：肺纤维化与肺泡再生；待本地复核。；日期补齐：Crossref 2016-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-798", "title": "《Pulmonary administration of phosphoinositide 3-kinase inhibitor is a curative treatment for chronic obstructive pulmonary disease by alveolar regeneration》论文发表", "date_start": "2015-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肺纤维化与肺泡再生报告或讨论可复核的学术证据。", "summary": "该节点将肺纤维化与肺泡再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1504" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肺纤维化、肺泡再生与呼吸修复", "notes": "第 282 轮补录：肺纤维化与肺泡再生；待本地复核。；日期补齐：Crossref 2015-09 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-799", "title": "《Extracellular vesicles from alveolar macrophages promotes pulmonary fibrosis through suppression of lung alveolar regeneration》论文发表", "date_start": "2026-01-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕肺纤维化与肺泡再生报告或讨论可复核的学术证据。", "summary": "该节点将肺纤维化与肺泡再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1505" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肺纤维化、肺泡再生与呼吸修复", "notes": "第 282 轮补录：肺纤维化与肺泡再生；待本地复核。；日期补齐：Crossref 2026-01-14 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-800", "title": "《Loss of primary cilia on cardiac fibroblast attenuates fibrosis and preserves cardiac function post myocardial infarction》论文发表", "date_start": "2026-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心脏纤维化与心肌功能报告或讨论可复核的学术证据。", "summary": "该节点将心脏纤维化与心肌功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1506" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心脏纤维化、心肌功能与心衰修复", "notes": "第 283 轮补录：心脏纤维化与心肌功能；待本地复核。；日期补齐：Crossref 2026-05 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-801", "title": "《Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload》论文发表", "date_start": "2017-09-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心脏纤维化与心肌功能报告或讨论可复核的学术证据。", "summary": "该节点将心脏纤维化与心肌功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1507" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心脏纤维化、心肌功能与心衰修复", "notes": "第 283 轮补录：心脏纤维化与心肌功能；待本地复核。；日期补齐：Crossref 2017-09-20 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-802", "title": "《Ginsenoside Rg2 attenuates myocardial fibrosis and improves cardiac function after myocardial infarction via AKT signaling pathway》论文发表", "date_start": "2020-11-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心脏纤维化与心肌功能报告或讨论可复核的学术证据。", "summary": "该节点将心脏纤维化与心肌功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1508" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心脏纤维化、心肌功能与心衰修复", "notes": "第 283 轮补录：心脏纤维化与心肌功能；待本地复核。；日期补齐：Crossref 2020-11-01 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-803", "title": "《Suppression of macrophage enriched miRNA 210-3p improves cardiac fibrosis and cardiac function following myocardial infarction》论文发表", "date_start": "2026-07-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心脏纤维化与心肌功能报告或讨论可复核的学术证据。", "summary": "该节点将心脏纤维化与心肌功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1509" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心脏纤维化、心肌功能与心衰修复", "notes": "第 283 轮补录：心脏纤维化与心肌功能；待本地复核。；日期补齐：Crossref 2026-07-03 (published-online, day, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-804", "title": "《Rat strain-related differences in myocardial adrenergic tone and the impact on cardiac fibrosis, adrenergic responsiveness and myocardial structure and function》论文发表", "date_start": "2007-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心脏纤维化与心肌功能报告或讨论可复核的学术证据。", "summary": "该节点将心脏纤维化与心肌功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1510" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心脏纤维化、心肌功能与心衰修复", "notes": "第 283 轮补录：心脏纤维化与心肌功能；待本地复核。；日期补齐：Crossref 2007-04 (published-print, month, v3)", "created_at": "2026-08-07T06:01:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-805", "title": "《White matter microstructure fingerprint of cerebral small vessel disease》论文发表", "date_start": "2026-06-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脑小血管病与白质完整报告或讨论可复核的学术证据。", "summary": "该节点将脑小血管病与白质完整的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1511" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑小血管病、白质完整与脑灌注", "notes": "第 284 轮补录：脑小血管病与白质完整；待本地复核。；日期补齐：Crossref 2026-06-06 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-806", "title": "《White matter lesions in cerebral small vessel disease》论文发表", "date_start": "2019-04-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脑小血管病与白质完整报告或讨论可复核的学术证据。", "summary": "该节点将脑小血管病与白质完整的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1512" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑小血管病、白质完整与脑灌注", "notes": "第 284 轮补录：脑小血管病与白质完整；待本地复核。；日期补齐：Crossref 2019-04-09 (published-print, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-807", "title": "《Quantifying the severity of white matter damage in Cerebral Small Vessel Disease》论文发表", "date_start": "2025-12-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脑小血管病与白质完整报告或讨论可复核的学术证据。", "summary": "该节点将脑小血管病与白质完整的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1513" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑小血管病、白质完整与脑灌注", "notes": "第 284 轮补录：脑小血管病与白质完整；待本地复核。；日期补齐：Crossref 2025-12-23 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-808", "title": "《Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms》论文发表", "date_start": "2017-03-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脑小血管病与白质完整报告或讨论可复核的学术证据。", "summary": "该节点将脑小血管病与白质完整的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1514" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑小血管病、白质完整与脑灌注", "notes": "第 284 轮补录：脑小血管病与白质完整；待本地复核。；日期补齐：Crossref 2017-03-28 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-809", "title": "《Heterogeneity of White Matter Hyperintensities in Cognitively Impaired Patients With Cerebral Small Vessel Disease》论文发表", "date_start": "2021-12-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕脑小血管病与白质完整报告或讨论可复核的学术证据。", "summary": "该节点将脑小血管病与白质完整的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1515" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "脑小血管病、白质完整与脑灌注", "notes": "第 284 轮补录：脑小血管病与白质完整；待本地复核。；日期补齐：Crossref 2021-12-09 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-810", "title": "《Abnormal Amyloid-β Duration, Tau, and Neurodegeneration in Cranial Images》论文发表", "date_start": "2025-09-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性蛋白病报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性蛋白病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1516" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行性蛋白病、淀粉样蛋白与tau", "notes": "第 285 轮补录：神经退行性蛋白病；待本地复核。；日期补齐：Crossref 2025-09-09 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-811", "title": "《Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease》论文发表", "date_start": "2024-04-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性蛋白病报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性蛋白病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1517" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行性蛋白病、淀粉样蛋白与tau", "notes": "第 285 轮补录：神经退行性蛋白病；待本地复核。；日期补齐：Crossref 2024-04-04 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-812", "title": "《Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein》论文发表", "date_start": "2025-08-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性蛋白病报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性蛋白病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1518" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行性蛋白病、淀粉样蛋白与tau", "notes": "第 285 轮补录：神经退行性蛋白病；待本地复核。；日期补齐：Crossref 2025-08-12 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-813", "title": "《The spatial distribution of coupling between tau and neurodegeneration in amyloid-β positive mild cognitive impairment》论文发表", "date_start": "2024-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性蛋白病报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性蛋白病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1519" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行性蛋白病、淀粉样蛋白与tau", "notes": "第 285 轮补录：神经退行性蛋白病；待本地复核。；日期补齐：Crossref 2024-04 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-814", "title": "《Putting the New Alzheimer Disease Amyloid, Tau, Neurodegeneration (AT[N]) Diagnostic System to the Test》论文发表", "date_start": "2019-06-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性蛋白病报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性蛋白病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1520" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经退行性蛋白病、淀粉样蛋白与tau", "notes": "第 285 轮补录：神经退行性蛋白病；待本地复核。；日期补齐：Crossref 2019-06-18 (published-print, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-815", "title": "《Physiological brain clearance architecture revealed by neuronal protein tracing》论文发表", "date_start": "2026-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白质聚集体清除报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质聚集体清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1521" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质聚集体、清除机制与神经保护", "notes": "第 286 轮补录：蛋白质聚集体清除；待本地复核。；日期补齐：Crossref 2026-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-816", "title": "《Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination》论文发表", "date_start": "2025-02-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白质聚集体清除报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质聚集体清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1522" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质聚集体、清除机制与神经保护", "notes": "第 286 轮补录：蛋白质聚集体清除；待本地复核。；日期补齐：Crossref 2025-02-07 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-817", "title": "《Clearance of protein aggregates during cell division》论文发表", "date_start": "2025-06-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白质聚集体清除报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质聚集体清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1523" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质聚集体、清除机制与神经保护", "notes": "第 286 轮补录：蛋白质聚集体清除；待本地复核。；日期补齐：Crossref 2025-06-06 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-818", "title": "《Antibody-mediated clearance of an ER-resident aggregate that causes glaucoma》论文发表", "date_start": "2024-12-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白质聚集体清除报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质聚集体清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1524" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质聚集体、清除机制与神经保护", "notes": "第 286 轮补录：蛋白质聚集体清除；待本地复核。；日期补齐：Crossref 2024-12-10 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-819", "title": "《Reactivated endogenous retroviruses promote protein aggregate spreading》论文发表", "date_start": "2023-08-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白质聚集体清除报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质聚集体清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1525" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白质聚集体、清除机制与神经保护", "notes": "第 286 轮补录：蛋白质聚集体清除；待本地复核。；日期补齐：Crossref 2023-08-18 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-820", "title": "《Mitophagy-Enhanced Nanoparticle-Engineered Mitochondria Restore Homeostasis of Mitochondrial Pool for Alleviating Pulmonary Fibrosis》论文发表", "date_start": "2024-11-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体自噬与能量稳态报告或讨论可复核的学术证据。", "summary": "该节点将线粒体自噬与能量稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1526" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体自噬、能量稳态与细胞韧性", "notes": "第 287 轮补录：线粒体自噬与能量稳态；待本地复核。；日期补齐：Crossref 2024-11-15 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-821", "title": "《Mitophagy in cardiovascular homeostasis》论文发表", "date_start": "2020-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体自噬与能量稳态报告或讨论可复核的学术证据。", "summary": "该节点将线粒体自噬与能量稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1527" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体自噬、能量稳态与细胞韧性", "notes": "第 287 轮补录：线粒体自噬与能量稳态；待本地复核。；日期补齐：Crossref 2020-06 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-822", "title": "《Putting energy into mitophagy》论文发表", "date_start": "2013-05-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体自噬与能量稳态报告或讨论可复核的学术证据。", "summary": "该节点将线粒体自噬与能量稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1528" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体自噬、能量稳态与细胞韧性", "notes": "第 287 轮补录：线粒体自噬与能量稳态；待本地复核。；日期补齐：Crossref 2013-05-09 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-823", "title": "《Enhanced brain mitophagy slows systemic aging》论文发表", "date_start": "2022-06-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体自噬与能量稳态报告或讨论可复核的学术证据。", "summary": "该节点将线粒体自噬与能量稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1529" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体自噬、能量稳态与细胞韧性", "notes": "第 287 轮补录：线粒体自噬与能量稳态；待本地复核。；日期补齐：Crossref 2022-06-17 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-824", "title": "《Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging》论文发表", "date_start": "2019-11-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体自噬与能量稳态报告或讨论可复核的学术证据。", "summary": "该节点将线粒体自噬与能量稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1530" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体自噬、能量稳态与细胞韧性", "notes": "第 287 轮补录：线粒体自噬与能量稳态；待本地复核。；日期补齐：Crossref 2019-11-04 (published-print, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-825", "title": "《Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity》论文发表", "date_start": "2026-01-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕内质网应激与蛋白稳态报告或讨论可复核的学术证据。", "summary": "该节点将内质网应激与蛋白稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1531" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内质网应激、未折叠蛋白反应与蛋白稳态", "notes": "第 288 轮补录：内质网应激与蛋白稳态；待本地复核。；日期补齐：Crossref 2026-01-26 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-826", "title": "《The endoplasmic reticulum proteostasis network and bone disease》论文发表", "date_start": "2026-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕内质网应激与蛋白稳态报告或讨论可复核的学术证据。", "summary": "该节点将内质网应激与蛋白稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1532" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内质网应激、未折叠蛋白反应与蛋白稳态", "notes": "第 288 轮补录：内质网应激与蛋白稳态；待本地复核。；日期补齐：Crossref 2026-02 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-827", "title": "《Zinc-redox crosstalk regulates proteostasis in the endoplasmic reticulum》论文发表", "date_start": "2026-04-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕内质网应激与蛋白稳态报告或讨论可复核的学术证据。", "summary": "该节点将内质网应激与蛋白稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1533" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内质网应激、未折叠蛋白反应与蛋白稳态", "notes": "第 288 轮补录：内质网应激与蛋白稳态；待本地复核。；日期补齐：Crossref 2026-04-22 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-828", "title": "《The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors》论文发表", "date_start": "2022-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕内质网应激与蛋白稳态报告或讨论可复核的学术证据。", "summary": "该节点将内质网应激与蛋白稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1534" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内质网应激、未折叠蛋白反应与蛋白稳态", "notes": "第 288 轮补录：内质网应激与蛋白稳态；待本地复核。；日期补齐：Crossref 2022-08 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-829", "title": "《Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes》论文发表", "date_start": "2020-12-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕内质网应激与蛋白稳态报告或讨论可复核的学术证据。", "summary": "该节点将内质网应激与蛋白稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1535" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内质网应激、未折叠蛋白反应与蛋白稳态", "notes": "第 288 轮补录：内质网应激与蛋白稳态；待本地复核。；日期补齐：Crossref 2020-12-09 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-830", "title": "《Nutrient-regulated control of lysosome function by signaling lipid conversion》论文发表", "date_start": "2025-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕溶酶体功能与细胞自净报告或讨论可复核的学术证据。", "summary": "该节点将溶酶体功能与细胞自净的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1536" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "溶酶体、细胞自净与降解功能", "notes": "第 289 轮补录：溶酶体功能与细胞自净；待本地复核。；日期补齐：Crossref 2025-05 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-831", "title": "《Targeted clearance of senescent cells alleviates alcohol-associated liver disease by restoring cellular function and immune balance》论文发表", "date_start": "2025-11-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕溶酶体功能与细胞自净报告或讨论可复核的学术证据。", "summary": "该节点将溶酶体功能与细胞自净的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1537" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "溶酶体、细胞自净与降解功能", "notes": "第 289 轮补录：溶酶体功能与细胞自净；待本地复核。；日期补齐：Crossref 2025-11-14 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-832", "title": "《Mitochondria-lysosome-related organelles mediate mitochondrial clearance during cellular dedifferentiation》论文发表", "date_start": "2023-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕溶酶体功能与细胞自净报告或讨论可复核的学术证据。", "summary": "该节点将溶酶体功能与细胞自净的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1538" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "溶酶体、细胞自净与降解功能", "notes": "第 289 轮补录：溶酶体功能与细胞自净；待本地复核。；日期补齐：Crossref 2023-10 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-833", "title": "《The Lysosome at the Intersection of Cellular Growth and Destruction》论文发表", "date_start": "2020-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕溶酶体功能与细胞自净报告或讨论可复核的学术证据。", "summary": "该节点将溶酶体功能与细胞自净的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1539" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "溶酶体、细胞自净与降解功能", "notes": "第 289 轮补录：溶酶体功能与细胞自净；待本地复核。；日期补齐：Crossref 2020-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-834", "title": "《Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis》论文发表", "date_start": "2019-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕溶酶体功能与细胞自净报告或讨论可复核的学术证据。", "summary": "该节点将溶酶体功能与细胞自净的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1540" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "溶酶体、细胞自净与降解功能", "notes": "第 289 轮补录：溶酶体功能与细胞自净；待本地复核。；日期补齐：Crossref 2019-06 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-835", "title": "《Membrane repair following filtroporation-induced cell permeabilization》论文发表", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞膜修复与机械韧性报告或讨论可复核的学术证据。", "summary": "该节点将细胞膜修复与机械韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1541" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞膜修复、机械韧性与细胞生存", "notes": "第 290 轮补录：细胞膜修复与机械韧性；待本地复核。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-836", "title": "《Time matters: the dynamics of plasma membrane repair》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞膜修复与机械韧性报告或讨论可复核的学术证据。", "summary": "该节点将细胞膜修复与机械韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1542" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞膜修复、机械韧性与细胞生存", "notes": "第 290 轮补录：细胞膜修复与机械韧性；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-837", "title": "《Membrane Tension Regulation is Required for Wound Repair》论文发表", "date_start": "2024-10-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞膜修复与机械韧性报告或讨论可复核的学术证据。", "summary": "该节点将细胞膜修复与机械韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1543" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞膜修复、机械韧性与细胞生存", "notes": "第 290 轮补录：细胞膜修复与机械韧性；待本地复核。；日期补齐：Crossref 2024-10-03 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-838", "title": "《Hybrid Cell Membrane‐Functionalized Matrixes for Modulating Inflammatory Microenvironment and Improving Bone Defect Repair》论文发表", "date_start": "2023-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞膜修复与机械韧性报告或讨论可复核的学术证据。", "summary": "该节点将细胞膜修复与机械韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1544" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞膜修复、机械韧性与细胞生存", "notes": "第 290 轮补录：细胞膜修复与机械韧性；待本地复核。；日期补齐：Crossref 2023-05 (published-online, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-839", "title": "《ATG9 assists lipid replenishment for lysosome membrane repair》论文发表", "date_start": "2025-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞膜修复与机械韧性报告或讨论可复核的学术证据。", "summary": "该节点将细胞膜修复与机械韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1545" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞膜修复、机械韧性与细胞生存", "notes": "第 290 轮补录：细胞膜修复与机械韧性；待本地复核。；日期补齐：Crossref 2025-10 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-840", "title": "《Epigenetic Modifiers as Game Changers for Healthy Aging》论文发表", "date_start": "2023-06-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕表观遗传重编程报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传重编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1546" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "表观遗传重编程、细胞年轻化与身份维持", "notes": "第 291 轮补录：表观遗传重编程；待本地复核。；日期补齐：Crossref 2023-06-06 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-841", "title": "《Rejuvenation by Partial Reprogramming of the Epigenome》论文发表", "date_start": "2017-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕表观遗传重编程报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传重编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1547" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "表观遗传重编程、细胞年轻化与身份维持", "notes": "第 291 轮补录：表观遗传重编程；待本地复核。；日期补齐：Crossref 2017-04 (published-online, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-842", "title": "《Rejuvenation of Adult Stem Cells: Is Age-Associated Dysfunction Epigenetic?》论文发表", "date_start": "2013-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕表观遗传重编程报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传重编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1548" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "表观遗传重编程、细胞年轻化与身份维持", "notes": "第 291 轮补录：表观遗传重编程；待本地复核。；日期补齐：Crossref 2013-04 (published-online, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-843", "title": "《Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock》论文发表", "date_start": "2012-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕表观遗传重编程报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传重编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1549" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "表观遗传重编程、细胞年轻化与身份维持", "notes": "第 291 轮补录：表观遗传重编程；待本地复核。；日期补齐：Crossref 2012-01 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-844", "title": "《Cellular reprogramming and epigenetic rejuvenation》论文发表", "date_start": "2021-09-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕表观遗传重编程报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传重编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1550" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "表观遗传重编程、细胞年轻化与身份维持", "notes": "第 291 轮补录：表观遗传重编程；待本地复核。；日期补齐：Crossref 2021-09-06 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-845", "title": "《In vivo brown adipogenic reprogramming induced by a small molecule cocktail》论文发表", "date_start": "2026-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕化学重编程与小分子疗法报告或讨论可复核的学术证据。", "summary": "该节点将化学重编程与小分子疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1551" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "化学重编程、小分子疗法与细胞状态重写", "notes": "第 292 轮补录：化学重编程与小分子疗法；待本地复核。；日期补齐：Crossref 2026-01 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-846", "title": "《Molecular time machines unleashed: small-molecule-driven reprogramming to reverse the senescence》论文发表", "date_start": "2026-01-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕化学重编程与小分子疗法报告或讨论可复核的学术证据。", "summary": "该节点将化学重编程与小分子疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1552" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "化学重编程、小分子疗法与细胞状态重写", "notes": "第 292 轮补录：化学重编程与小分子疗法；待本地复核。；日期补齐：Crossref 2026-01-12 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-847", "title": "《Improving chemical reprogramming strategies》论文发表", "date_start": "2025-02-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕化学重编程与小分子疗法报告或讨论可复核的学术证据。", "summary": "该节点将化学重编程与小分子疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1553" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "化学重编程、小分子疗法与细胞状态重写", "notes": "第 292 轮补录：化学重编程与小分子疗法；待本地复核。；日期补齐：Crossref 2025-02-17 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-848", "title": "《Robust small molecule-aided cardiac reprogramming systems selective to cardiac fibroblasts》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕化学重编程与小分子疗法报告或讨论可复核的学术证据。", "summary": "该节点将化学重编程与小分子疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1554" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "化学重编程、小分子疗法与细胞状态重写", "notes": "第 292 轮补录：化学重编程与小分子疗法；待本地复核。；日期补齐：Crossref 2023-12 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-849", "title": "《Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes》论文发表", "date_start": "2016-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕化学重编程与小分子疗法报告或讨论可复核的学术证据。", "summary": "该节点将化学重编程与小分子疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1555" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "化学重编程、小分子疗法与细胞状态重写", "notes": "第 292 轮补录：化学重编程与小分子疗法；待本地复核。；日期补齐：Crossref 2016-07 (published-print, month, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-850", "title": "《In vivo base editing gene therapy for heterozygous familial hypercholesterolemia: a phase 1 trial》论文发表", "date_start": "2026-03-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因疗法与体内编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因疗法与体内编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1556" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因疗法、体内编辑与持久修复", "notes": "第 293 轮补录：基因疗法与体内编辑；待本地复核。；日期补齐：Crossref 2026-03-03 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-851", "title": "《Personalized, in vivo gene editing for a newborn》论文发表", "date_start": "2025-06-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因疗法与体内编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因疗法与体内编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1557" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因疗法、体内编辑与持久修复", "notes": "第 293 轮补录：基因疗法与体内编辑；待本地复核。；日期补齐：Crossref 2025-06-06 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-852", "title": "《In vivo gene editing for inherited vision loss》论文发表", "date_start": "2024-05-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因疗法与体内编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因疗法与体内编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1558" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因疗法、体内编辑与持久修复", "notes": "第 293 轮补录：基因疗法与体内编辑；待本地复核。；日期补齐：Crossref 2024-05-20 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-853", "title": "《Therapeutic in vivo genome editing: innovations and challenges in rAAV vector-based CRISPR delivery》论文发表", "date_start": "2025-11-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因疗法与体内编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因疗法与体内编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1559" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因疗法、体内编辑与持久修复", "notes": "第 293 轮补录：基因疗法与体内编辑；待本地复核。；日期补齐：Crossref 2025-11-12 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-854", "title": "《CRISPR/Cas-Dependent and Nuclease-Free\n In Vivo\n Therapeutic Gene Editing》论文发表", "date_start": "2021-03-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因疗法与体内编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因疗法与体内编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1560" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "基因疗法、体内编辑与持久修复", "notes": "第 293 轮补录：基因疗法与体内编辑；待本地复核。；日期补齐：Crossref 2021-03-17 (published-online, day, v3)", "created_at": "2026-08-07T06:01:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-855", "title": "《Empower the age of smart mRNA medicine: Programmable RNA sensor and molecular tools refine therapeutic payload production》论文发表", "date_start": "2025-04-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕RNA疗法与mRNA医学报告或讨论可复核的学术证据。", "summary": "该节点将RNA疗法与mRNA医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1561" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "RNA疗法、mRNA医学与可编程治疗", "notes": "第 294 轮补录：RNA疗法与mRNA医学；待本地复核。；日期补齐：Crossref 2025-04-04 (published-print, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-856", "title": "《mRNA vaccine quality analysis using RNA sequencing》论文发表", "date_start": "2023-09-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕RNA疗法与mRNA医学报告或讨论可复核的学术证据。", "summary": "该节点将RNA疗法与mRNA医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1562" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "RNA疗法、mRNA医学与可编程治疗", "notes": "第 294 轮补录：RNA疗法与mRNA医学；待本地复核。；日期补齐：Crossref 2023-09-21 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-857", "title": "《mRNA therapy for a rare childhood disease》论文发表", "date_start": "2024-04-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕RNA疗法与mRNA医学报告或讨论可复核的学术证据。", "summary": "该节点将RNA疗法与mRNA医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1563" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "RNA疗法、mRNA医学与可编程治疗", "notes": "第 294 轮补录：RNA疗法与mRNA医学；待本地复核。；日期补齐：Crossref 2024-04-22 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-858", "title": "《mRNA therapeutics: Transforming medicine through innovation in design, delivery, and disease treatment》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕RNA疗法与mRNA医学报告或讨论可复核的学术证据。", "summary": "该节点将RNA疗法与mRNA医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1564" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "RNA疗法、mRNA医学与可编程治疗", "notes": "第 294 轮补录：RNA疗法与mRNA医学；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-859", "title": "《mRNA therapy as primary and bridge therapy for inborn errors of metabolism》论文发表", "date_start": "2025-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕RNA疗法与mRNA医学报告或讨论可复核的学术证据。", "summary": "该节点将RNA疗法与mRNA医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1565" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "RNA疗法、mRNA医学与可编程治疗", "notes": "第 294 轮补录：RNA疗法与mRNA医学；待本地复核。；日期补齐：Crossref 2025-03 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-860", "title": "《Advances in cell therapy for orthopedic diseases: bridging immune modulation and regeneration》论文发表", "date_start": "2025-04-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕细胞疗法与免疫重建报告或讨论可复核的学术证据。", "summary": "该节点将细胞疗法与免疫重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1566" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞疗法、免疫重建与血液肿瘤修复", "notes": "第 295 轮补录：细胞疗法与免疫重建；待本地复核。；日期补齐：Crossref 2025-04-10 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-861", "title": "《Immune reconstitution following allogeneic hematopoietic cell transplantation and CAR-T therapy: dynamics, determinants, and directions》论文发表", "date_start": "2025-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕细胞疗法与免疫重建报告或讨论可复核的学术证据。", "summary": "该节点将细胞疗法与免疫重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1567" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞疗法、免疫重建与血液肿瘤修复", "notes": "第 295 轮补录：细胞疗法与免疫重建；待本地复核。；日期补齐：Crossref 2025-06 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-862", "title": "《Kinetics of Immune Reconstitution after CD19 CAR-T Cell Therapy in ALL Patients》论文发表", "date_start": "2019-11-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕细胞疗法与免疫重建报告或讨论可复核的学术证据。", "summary": "该节点将细胞疗法与免疫重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1568" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞疗法、免疫重建与血液肿瘤修复", "notes": "第 295 轮补录：细胞疗法与免疫重建；待本地复核。；日期补齐：Crossref 2019-11-13 (published-print, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-863", "title": "《In vivo T-cell dynamics during immune reconstitution after hematopoietic stem cell gene therapy in adenosine deaminase severe combined immune deficiency》论文发表", "date_start": "2011-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕细胞疗法与免疫重建报告或讨论可复核的学术证据。", "summary": "该节点将细胞疗法与免疫重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1569" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞疗法、免疫重建与血液肿瘤修复", "notes": "第 295 轮补录：细胞疗法与免疫重建；待本地复核。；日期补齐：Crossref 2011-06 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-864", "title": "《Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man》论文发表", "date_start": "2008-11-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕细胞疗法与免疫重建报告或讨论可复核的学术证据。", "summary": "该节点将细胞疗法与免疫重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1570" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞疗法、免疫重建与血液肿瘤修复", "notes": "第 295 轮补录：细胞疗法与免疫重建；待本地复核。；日期补齐：Crossref 2008-11-15 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-865", "title": "《Bioethical implications of organ‐on‐a‐chip on modernizing drug development》论文发表", "date_start": "2023-08-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕器官芯片与药物安全报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片与药物安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1571" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、药物安全与毒理学模型", "notes": "第 296 轮补录：器官芯片与药物安全；待本地复核。；日期补齐：Crossref 2023-08-14 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-866", "title": "《Adoption of organ-on-chip platforms by the pharmaceutical industry》论文发表", "date_start": "2021-10-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕器官芯片与药物安全报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片与药物安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1572" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、药物安全与毒理学模型", "notes": "第 296 轮补录：器官芯片与药物安全；待本地复核。；日期补齐：Crossref 2021-10-13 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-867", "title": "《Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety》论文发表", "date_start": "2020", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕器官芯片与药物安全报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片与药物安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1573" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、药物安全与毒理学模型", "notes": "第 296 轮补录：器官芯片与药物安全；待本地复核。；日期补齐：Crossref 2020 (published-online, year, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-868", "title": "《Human organotypic bioconstructs from organ-on-chip devices for human-predictive biological insights on drug candidates》论文发表", "date_start": "2019-07-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕器官芯片与药物安全报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片与药物安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1574" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、药物安全与毒理学模型", "notes": "第 296 轮补录：器官芯片与药物安全；待本地复核。；日期补齐：Crossref 2019-07-03 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-869", "title": "《Organ-on-chip technology to revolutionise drug development》论文发表", "date_start": "2014", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕器官芯片与药物安全报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片与药物安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1575" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "器官芯片、药物安全与毒理学模型", "notes": "第 296 轮补录：器官芯片与药物安全；待本地复核。；日期补齐：Crossref 2014 (published-print, year, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-870", "title": "《An insight in the future of healthcare: integrating digital twin for personalized medicine》论文发表", "date_start": "2024-04-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与寿命预测报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与寿命预测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1576" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、寿命预测与健康决策", "notes": "第 297 轮补录：数字孪生与寿命预测；待本地复核。；日期补齐：Crossref 2024-04-23 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-871", "title": "《Human Digital Twin for Personalized Healthcare: Vision, Architecture and Future Directions》论文发表", "date_start": "2023-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与寿命预测报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与寿命预测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1577" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、寿命预测与健康决策", "notes": "第 297 轮补录：数字孪生与寿命预测；待本地复核。；日期补齐：Crossref 2023-03 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-872", "title": "《Digital twin for healthcare systems》论文发表", "date_start": "2023-09-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与寿命预测报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与寿命预测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1578" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、寿命预测与健康决策", "notes": "第 297 轮补录：数字孪生与寿命预测；待本地复核。；日期补齐：Crossref 2023-09-07 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-873", "title": "《Digital Twin: Generalization, characterization and implementation》论文发表", "date_start": "2021-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与寿命预测报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与寿命预测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1579" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、寿命预测与健康决策", "notes": "第 297 轮补录：数字孪生与寿命预测；待本地复核。；日期补齐：Crossref 2021-06 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-874", "title": "《Design for a digital twin in clinical patient care》论文发表", "date_start": "2026-02-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与寿命预测报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与寿命预测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1580" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数字孪生、寿命预测与健康决策", "notes": "第 297 轮补录：数字孪生与寿命预测；待本地复核。；日期补齐：Crossref 2026-02-02 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-388", "title": "《Longevity medicine: upskilling the physicians of tomorrow》论文发表", "date_start": "2021-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度与医学基础设施报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度与医学基础设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1581" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度、医学基础设施与制度支持", "notes": "第 298 轮补录：长寿逃逸速度与医学基础设施；待本地复核。；日期补齐：Crossref 2021-04 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-389", "title": "《No more band-aids: health-care system reform》论文发表", "date_start": "2021-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度与医学基础设施报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度与医学基础设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1582" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度、医学基础设施与制度支持", "notes": "第 298 轮补录：长寿逃逸速度与医学基础设施；待本地复核。；日期补齐：Crossref 2021-12 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-390", "title": "《The Lancet Healthy Longevity: Health For All, For Longer》论文发表", "date_start": "2020-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度与医学基础设施报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度与医学基础设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1583" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度、医学基础设施与制度支持", "notes": "第 298 轮补录：长寿逃逸速度与医学基础设施；待本地复核。；日期补齐：Crossref 2020-10 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-391", "title": "《Human rights for healthy longevity》论文发表", "date_start": "2023-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度与医学基础设施报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度与医学基础设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1584" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度、医学基础设施与制度支持", "notes": "第 298 轮补录：长寿逃逸速度与医学基础设施；待本地复核。；日期补齐：Crossref 2023-10 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-392", "title": "《Digital Transformation in Medicine to Enhance Quality of Life, Longevity, and Health Equity》论文发表", "date_start": "2022-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度与医学基础设施报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度与医学基础设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1585" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "长寿逃逸速度、医学基础设施与制度支持", "notes": "第 298 轮补录：长寿逃逸速度与医学基础设施；待本地复核。；日期补齐：Crossref 2022-04 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-393", "title": "《Personal recovery and future self-continuity in individuals with schizophrenia》论文发表", "date_start": "2025-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体连续性与未来选择权报告或讨论可复核的学术证据。", "summary": "该节点将主体连续性与未来选择权的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1586" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "主体连续性、未来选择权与身份治理", "notes": "第 299 轮补录：主体连续性与未来选择权；待本地复核。；日期补齐：Crossref 2025-06 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-394", "title": "《Towards a Human Right to Psychological Continuity? Reflections on the Rights to Personal Identity, Self-Determination, and Personal Integrity》论文发表", "date_start": "2024-04-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体连续性与未来选择权报告或讨论可复核的学术证据。", "summary": "该节点将主体连续性与未来选择权的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1587" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "主体连续性、未来选择权与身份治理", "notes": "第 299 轮补录：主体连续性与未来选择权；待本地复核。；日期补齐：Crossref 2024-04-11 (published-print, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-395", "title": "《Using Identity-Based Motivation to Enhance Future Self-Continuity》论文发表", "date_start": "2024-08-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体连续性与未来选择权报告或讨论可复核的学术证据。", "summary": "该节点将主体连续性与未来选择权的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1588" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "主体连续性、未来选择权与身份治理", "notes": "第 299 轮补录：主体连续性与未来选择权；待本地复核。；日期补齐：Crossref 2024-08-01 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-396", "title": "《Personal Identity and Cortical Midline Structure (CMS): Do Temporal Features of CMS Neural Activity Transform Into “Self-Continuity”?》论文发表", "date_start": "2017-08-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体连续性与未来选择权报告或讨论可复核的学术证据。", "summary": "该节点将主体连续性与未来选择权的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1589" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "主体连续性、未来选择权与身份治理", "notes": "第 299 轮补录：主体连续性与未来选择权；待本地复核。；日期补齐：Crossref 2017-08-18 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-397", "title": "《Contribution of past and future self-defining event networks to personal identity》论文发表", "date_start": "2016-07-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体连续性与未来选择权报告或讨论可复核的学术证据。", "summary": "该节点将主体连续性与未来选择权的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1590" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "主体连续性、未来选择权与身份治理", "notes": "第 299 轮补录：主体连续性与未来选择权；待本地复核。；日期补齐：Crossref 2016-07-07 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-052", "title": "《Governance of artificial intelligence in Southeast Asia》论文发表", "date_start": "2024-10-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕文明级风险与长期治理报告或讨论可复核的学术证据。", "summary": "该节点将文明级风险与长期治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1591" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "文明级风险、长期治理与技术安全", "notes": "第 300 轮补录：文明级风险与长期治理；待本地复核。；日期补齐：Crossref 2024-10-15 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-053", "title": "《Artificial intelligence, complexity, and systemic resilience in global governance》论文发表", "date_start": "2025-06-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕文明级风险与长期治理报告或讨论可复核的学术证据。", "summary": "该节点将文明级风险与长期治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1592" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "文明级风险、长期治理与技术安全", "notes": "第 300 轮补录：文明级风险与长期治理；待本地复核。；日期补齐：Crossref 2025-06-02 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-054", "title": "《Governing the safety of artificial intelligence in healthcare》论文发表", "date_start": "2019-04-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕文明级风险与长期治理报告或讨论可复核的学术证据。", "summary": "该节点将文明级风险与长期治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1593" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "文明级风险、长期治理与技术安全", "notes": "第 300 轮补录：文明级风险与长期治理；待本地复核。；日期补齐：Crossref 2019-04-12 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-055", "title": "《'Solving for X?' Towards a problem-finding framework to ground long-term governance strategies for artificial intelligence》论文发表", "date_start": "2021-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕文明级风险与长期治理报告或讨论可复核的学术证据。", "summary": "该节点将文明级风险与长期治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1594" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "文明级风险、长期治理与技术安全", "notes": "第 300 轮补录：文明级风险与长期治理；待本地复核。；日期补齐：Crossref 2021-02 (published-print, month, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-056", "title": "《Comparative Analysis of Long-Term Governance Problems: Risks of Climate Change and Artificial Intelligence》论文发表", "date_start": "2024-11-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕文明级风险与长期治理报告或讨论可复核的学术证据。", "summary": "该节点将文明级风险与长期治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1595" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "文明级风险、长期治理与技术安全", "notes": "第 300 轮补录：文明级风险与长期治理；待本地复核。；日期补齐：Crossref 2024-11-19 (published-online, day, v3)", "created_at": "2026-08-07T06:01:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-875", "title": "《Integrated evaluation of telomerase activation and telomere maintenance across cancer cell lines》论文发表", "date_start": "2021-09-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕端粒酶激活与染色体端粒维持报告或讨论可复核的学术证据。", "summary": "该节点将端粒酶激活与染色体端粒维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1596" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 301 轮补录：端粒酶激活与染色体端粒维持；待本地复核。；日期补齐：Crossref 2021-09-06 (published-online, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-876", "title": "《Break-induced replication and telomerase-independent telomere maintenance require Pol32》论文发表", "date_start": "2007-08-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕端粒酶激活与染色体端粒维持报告或讨论可复核的学术证据。", "summary": "该节点将端粒酶激活与染色体端粒维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1597" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 301 轮补录：端粒酶激活与染色体端粒维持；待本地复核。；日期补齐：Crossref 2007-08-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-877", "title": "《EXO1 Contributes to Telomere Maintenance in Both Telomerase-Proficient and Telomerase-Deficient Saccharomyces cerevisiae》论文发表", "date_start": "2004-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕端粒酶激活与染色体端粒维持报告或讨论可复核的学术证据。", "summary": "该节点将端粒酶激活与染色体端粒维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1598" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 301 轮补录：端粒酶激活与染色体端粒维持；待本地复核。；日期补齐：Crossref 2004-04-01 (published-print, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-878", "title": "《EXO1 Contributes to Telomere Maintenance in Both Telomerase-Proficient and Telomerase-Deficient Saccharomyces cerevisiae》论文发表", "date_start": "2004-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕端粒酶激活与染色体端粒维持报告或讨论可复核的学术证据。", "summary": "该节点将端粒酶激活与染色体端粒维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1599" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 301 轮补录：端粒酶激活与染色体端粒维持；待本地复核。；日期补齐：Crossref 2004-04-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-879", "title": "《Telomerase Regulation at the Telomere》论文发表", "date_start": "2004-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕端粒酶激活与染色体端粒维持报告或讨论可复核的学术证据。", "summary": "该节点将端粒酶激活与染色体端粒维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1600" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 301 轮补录：端粒酶激活与染色体端粒维持；待本地复核。；日期补齐：Crossref 2004-04 (published-print, month, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-880", "title": "《Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A》论文发表", "date_start": "2009-01-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕DNA损伤修复与基因组稳定报告或讨论可复核的学术证据。", "summary": "该节点将DNA损伤修复与基因组稳定的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1601" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 302 轮补录：DNA损伤修复与基因组稳定；待本地复核。；日期补齐：Crossref 2009-01-16 (published-online, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-881", "title": "《Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation》论文发表", "date_start": "2008-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕DNA损伤修复与基因组稳定报告或讨论可复核的学术证据。", "summary": "该节点将DNA损伤修复与基因组稳定的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1602" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 302 轮补录：DNA损伤修复与基因组稳定；待本地复核。；日期补齐：Crossref 2008-10 (published-print, month, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-882", "title": "《Endogenous DNA Damage as a Source of Genomic Instability in Cancer》论文发表", "date_start": "2017-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕DNA损伤修复与基因组稳定报告或讨论可复核的学术证据。", "summary": "该节点将DNA损伤修复与基因组稳定的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1603" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 302 轮补录：DNA损伤修复与基因组稳定；待本地复核。；日期补齐：Crossref 2017-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-883", "title": "《Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development》论文发表", "date_start": "2000-04", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕DNA损伤修复与基因组稳定报告或讨论可复核的学术证据。", "summary": "该节点将DNA损伤修复与基因组稳定的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1604" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 302 轮补录：DNA损伤修复与基因组稳定；待本地复核。；日期补齐：Crossref 2000-04 (published-print, month, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-884", "title": "《DNA strands show symmetry in damage tolerance but asymmetries in repair efficiency》论文发表", "date_start": "2024-08-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕DNA损伤修复与基因组稳定报告或讨论可复核的学术证据。", "summary": "该节点将DNA损伤修复与基因组稳定的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1605" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 302 轮补录：DNA损伤修复与基因组稳定；待本地复核。；日期补齐：Crossref 2024-08-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-885", "title": "《The epigenetic clock: a molecular crystal ball for human aging?》论文发表", "date_start": "2019-01-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕表观遗传时钟与干预报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传时钟与干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1606" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 303 轮补录：表观遗传时钟与干预；待本地复核。；日期补齐：Crossref 2019-01-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-886", "title": "《An epigenetic aging clock for dogs and wolves》论文发表", "date_start": "2017-03-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕表观遗传时钟与干预报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传时钟与干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1607" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 303 轮补录：表观遗传时钟与干预；待本地复核。；日期补齐：Crossref 2017-03-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-887", "title": "《An epigenetic clock controls aging》论文发表", "date_start": "2015-11-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕表观遗传时钟与干预报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传时钟与干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1608" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 303 轮补录：表观遗传时钟与干预；待本地复核。；日期补齐：Crossref 2015-11-25 (published-online, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-888", "title": "《Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, development, and cellular dedifferentiation》论文发表", "date_start": "2024-01-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕表观遗传时钟与干预报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传时钟与干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1609" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 303 轮补录：表观遗传时钟与干预；待本地复核。；日期补齐：Crossref 2024-01-26 (published-online, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-889", "title": "《Various diseases and conditions are strongly associated with the next-generation epigenetic aging clock CheekAge》论文发表", "date_start": "2025-03-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕表观遗传时钟与干预报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传时钟与干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1610" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 303 轮补录：表观遗传时钟与干预；待本地复核。；日期补齐：Crossref 2025-03-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:26Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-890", "title": "《Rejuvenation by Therapeutic Elimination of Senescent Cells》论文发表", "date_start": "2017-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕衰老细胞清除与组织年轻化报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除与组织年轻化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1611" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 304 轮补录：衰老细胞清除与组织年轻化；待本地复核。；日期补齐：Crossref 2017-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-891", "title": "《Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline》论文发表", "date_start": "2018-09-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕衰老细胞清除与组织年轻化报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除与组织年轻化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1612" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 304 轮补录：衰老细胞清除与组织年轻化；待本地复核。；日期补齐：Crossref 2018-09-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-892", "title": "《Abstract 4344658: Endothelial cell specific senescent cell clearance alleviates metabolic dysfunction in obese mice》论文发表", "date_start": "2025-11-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕衰老细胞清除与组织年轻化报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除与组织年轻化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1613" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 304 轮补录：衰老细胞清除与组织年轻化；待本地复核。；日期补齐：Crossref 2025-11-04 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-893", "title": "《Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging》论文发表", "date_start": "2026-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕衰老细胞清除与组织年轻化报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除与组织年轻化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1614" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 304 轮补录：衰老细胞清除与组织年轻化；待本地复核。；日期补齐：Crossref 2026-07-16 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-894", "title": "《Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders》论文发表", "date_start": "2011-11-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕衰老细胞清除与组织年轻化报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除与组织年轻化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1615" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 304 轮补录：衰老细胞清除与组织年轻化；待本地复核。；日期补齐：Crossref 2011-11-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-895", "title": "《Imaging stem-cell-driven regeneration in mammals》论文发表", "date_start": "2008-05-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕干细胞耗竭与再生报告或讨论可复核的学术证据。", "summary": "该节点将干细胞耗竭与再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1616" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 305 轮补录：干细胞耗竭与再生；待本地复核。；日期补齐：Crossref 2008-05-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-896", "title": "《Researchers rejuvenate aging mice with stem cell genes》论文发表", "date_start": "2016-12-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕干细胞耗竭与再生报告或讨论可复核的学术证据。", "summary": "该节点将干细胞耗竭与再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1617" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 305 轮补录：干细胞耗竭与再生；待本地复核。；日期补齐：Crossref 2016-12-15 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-897", "title": "《Stem cell factors reverse signs of aging in mice》论文发表", "date_start": "2023-01-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕干细胞耗竭与再生报告或讨论可复核的学术证据。", "summary": "该节点将干细胞耗竭与再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1618" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 305 轮补录：干细胞耗竭与再生；待本地复核。；日期补齐：Crossref 2023-01-20 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-898", "title": "《Cholesterol induces T cell exhaustion》论文发表", "date_start": "2019-09-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕干细胞耗竭与再生报告或讨论可复核的学术证据。", "summary": "该节点将干细胞耗竭与再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1619" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 305 轮补录：干细胞耗竭与再生；待本地复核。；日期补齐：Crossref 2019-09-18 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-899", "title": "《Mitochondrial oxidative phosphorylation is linked to T-cell exhaustion》论文发表", "date_start": "2020-09-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕干细胞耗竭与再生报告或讨论可复核的学术证据。", "summary": "该节点将干细胞耗竭与再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1620" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 305 轮补录：干细胞耗竭与再生；待本地复核。；日期补齐：Crossref 2020-09-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-900", "title": "《Molecular chaperones in protein folding and proteostasis》论文发表", "date_start": "2011-07-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白稳态与分子伴侣报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态与分子伴侣的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1621" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 306 轮补录：蛋白稳态与分子伴侣；待本地复核。；日期补齐：Crossref 2011-07-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-901", "title": "《Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1》论文发表", "date_start": "2019-09-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白稳态与分子伴侣报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态与分子伴侣的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1622" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 306 轮补录：蛋白稳态与分子伴侣；待本地复核。；日期补齐：Crossref 2019-09-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-902", "title": "《FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging》论文发表", "date_start": "2010-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白稳态与分子伴侣报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态与分子伴侣的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1623" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 306 轮补录：蛋白稳态与分子伴侣；待本地复核。；日期补齐：Crossref 2010-11 (published-print, month, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-903", "title": "《Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling》论文发表", "date_start": "2013-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白稳态与分子伴侣报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态与分子伴侣的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1624" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 306 轮补录：蛋白稳态与分子伴侣；待本地复核。；日期补齐：Crossref 2013-06 (published-print, month, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-904", "title": "《Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23》论文发表", "date_start": "1996-12-06", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕蛋白稳态与分子伴侣报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态与分子伴侣的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1625" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 306 轮补录：蛋白稳态与分子伴侣；待本地复核。；日期补齐：Crossref 1996-12-06 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-905", "title": "《Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism》论文发表", "date_start": "2020-02-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体功能与能量代谢报告或讨论可复核的学术证据。", "summary": "该节点将线粒体功能与能量代谢的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1626" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 307 轮补录：线粒体功能与能量代谢；待本地复核。；日期补齐：Crossref 2020-02-23 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-906", "title": "《Activation of mitochondrial energy metabolism protects against cardiac failure》论文发表", "date_start": "2010-11-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体功能与能量代谢报告或讨论可复核的学术证据。", "summary": "该节点将线粒体功能与能量代谢的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1627" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 307 轮补录：线粒体功能与能量代谢；待本地复核。；日期补齐：Crossref 2010-11-16 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-907", "title": "《Comprehensive analysis of mitochondrial energy metabolism–related genes and immune infiltration in intervertebral disk degeneration》论文发表", "date_start": "2025-09-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体功能与能量代谢报告或讨论可复核的学术证据。", "summary": "该节点将线粒体功能与能量代谢的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1628" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 307 轮补录：线粒体功能与能量代谢；待本地复核。；日期补齐：Crossref 2025-09-05 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-908", "title": "《Caveolin-1 controls mitochondrial function through regulation of m-AAA mitochondrial protease》论文发表", "date_start": "2016-10-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕线粒体功能与能量代谢报告或讨论可复核的学术证据。", "summary": "该节点将线粒体功能与能量代谢的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1629" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 307 轮补录：线粒体功能与能量代谢；待本地复核。；日期补齐：Crossref 2016-10-04 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-910", "title": "《Autophagy as a Regulated Pathway of Cellular Degradation》论文发表", "date_start": "2000-12", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞自噬与溶酶体报告或讨论可复核的学术证据。", "summary": "该节点将细胞自噬与溶酶体的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1631" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 308 轮补录：细胞自噬与溶酶体；待本地复核。；日期补齐：Crossref 2000-12 (published-print, month, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-911", "title": "《Biological Functions of Autophagy Genes: A Disease Perspective》论文发表", "date_start": "2019-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞自噬与溶酶体报告或讨论可复核的学术证据。", "summary": "该节点将细胞自噬与溶酶体的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1632" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 308 轮补录：细胞自噬与溶酶体；待本地复核。；日期补齐：Crossref 2019-01 (published-print, month, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-912", "title": "《Signals from the lysosome: a control centre for cellular clearance and energy metabolism》论文发表", "date_start": "2013-04-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞自噬与溶酶体报告或讨论可复核的学术证据。", "summary": "该节点将细胞自噬与溶酶体的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1633" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 308 轮补录：细胞自噬与溶酶体；待本地复核。；日期补齐：Crossref 2013-04-23 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-913", "title": "《The origin of the autophagosomal membrane》论文发表", "date_start": "2010-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞自噬与溶酶体报告或讨论可复核的学术证据。", "summary": "该节点将细胞自噬与溶酶体的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1634" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 308 轮补录：细胞自噬与溶酶体；待本地复核。；日期补齐：Crossref 2010-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-914", "title": "《Autophagy fights disease through cellular self-digestion》论文发表", "date_start": "2008-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕细胞自噬与溶酶体报告或讨论可复核的学术证据。", "summary": "该节点将细胞自噬与溶酶体的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1635" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 308 轮补录：细胞自噬与溶酶体；待本地复核。；日期补齐：Crossref 2008-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-915", "title": "《Aging without inflammaging: lesson from Spalax》论文发表", "date_start": "2020-08-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕炎症衰老与免疫报告或讨论可复核的学术证据。", "summary": "该节点将炎症衰老与免疫的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1636" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 309 轮补录：炎症衰老与免疫；待本地复核。；日期补齐：Crossref 2020-08-27 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-916", "title": "《Is RAGE the receptor for inflammaging?》论文发表", "date_start": "2019-09-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕炎症衰老与免疫报告或讨论可复核的学术证据。", "summary": "该节点将炎症衰老与免疫的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1637" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 309 轮补录：炎症衰老与免疫；待本地复核。；日期补齐：Crossref 2019-09-08 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-917", "title": "《Inflammaging: disturbed interplay between autophagy and inflammasomes》论文发表", "date_start": "2012-03-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕炎症衰老与免疫报告或讨论可复核的学术证据。", "summary": "该节点将炎症衰老与免疫的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1638" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 309 轮补录：炎症衰老与免疫；待本地复核。；日期补齐：Crossref 2012-03-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-918", "title": "《Integrating cardiovascular risk biomarkers in the context of inflammaging》论文发表", "date_start": "2024-10-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕炎症衰老与免疫报告或讨论可复核的学术证据。", "summary": "该节点将炎症衰老与免疫的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1639" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 309 轮补录：炎症衰老与免疫；待本地复核。；日期补齐：Crossref 2024-10-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-919", "title": "《DNA methylation clocks struggle to distinguish inflammaging from healthy aging, but feature rectification improves coherence and enhances detection of inflammaging》论文发表", "date_start": "2025-01-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕炎症衰老与免疫报告或讨论可复核的学术证据。", "summary": "该节点将炎症衰老与免疫的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1640" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 309 轮补录：炎症衰老与免疫；待本地复核。；日期补齐：Crossref 2025-01-18 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-920", "title": "《Deep learning and generative artificial intelligence in aging research and healthy longevity medicine》论文发表", "date_start": "2025-01-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕微生物组与健康长寿报告或讨论可复核的学术证据。", "summary": "该节点将微生物组与健康长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1641" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 310 轮补录：微生物组与健康长寿；待本地复核。；日期补齐：Crossref 2025-01-16 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-921", "title": "《Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondria》论文发表", "date_start": "2017-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕微生物组与健康长寿报告或讨论可复核的学术证据。", "summary": "该节点将微生物组与健康长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1642" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 310 轮补录：微生物组与健康长寿；待本地复核。；日期补齐：Crossref 2017-06 (published-print, month, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-922", "title": "《Microbiome: That healthy gut feeling》论文发表", "date_start": "2011-12-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕微生物组与健康长寿报告或讨论可复核的学术证据。", "summary": "该节点将微生物组与健康长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1643" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 310 轮补录：微生物组与健康长寿；待本地复核。；日期补齐：Crossref 2011-12-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-923", "title": "《Could social relationships be key to reaching healthy longevity?》论文发表", "date_start": "2023-06-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕微生物组与健康长寿报告或讨论可复核的学术证据。", "summary": "该节点将微生物组与健康长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1644" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 310 轮补录：微生物组与健康长寿；待本地复核。；日期补齐：Crossref 2023-06-29 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-924", "title": "《Structure, function and diversity of the healthy human microbiome》论文发表", "date_start": "2012-06-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕微生物组与健康长寿报告或讨论可复核的学术证据。", "summary": "该节点将微生物组与健康长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1645" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 310 轮补录：微生物组与健康长寿；待本地复核。；日期补齐：Crossref 2012-06-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-925", "title": "《The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics》论文发表", "date_start": "2002-07-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性疾病与衰老报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性疾病与衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1646" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 311 轮补录：神经退行性疾病与衰老；待本地复核。；日期补齐：Crossref 2002-07-19 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-926", "title": "《Alzheimer's Disease Is a Synaptic Failure》论文发表", "date_start": "2002-10-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性疾病与衰老报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性疾病与衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1647" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 311 轮补录：神经退行性疾病与衰老；待本地复核。；日期补齐：Crossref 2002-10-25 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-927", "title": "《Self-propagation of pathogenic protein aggregates in neurodegenerative diseases》论文发表", "date_start": "2013-09-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性疾病与衰老报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性疾病与衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1648" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 311 轮补录：神经退行性疾病与衰老；待本地复核。；日期补齐：Crossref 2013-09-04 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-928", "title": "《Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks》论文发表", "date_start": "2010-06-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性疾病与衰老报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性疾病与衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1649" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 311 轮补录：神经退行性疾病与衰老；待本地复核。；日期补齐：Crossref 2010-06-25 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-929", "title": "《Neurodegenerative diseases and oxidative stress》论文发表", "date_start": "2004-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕神经退行性疾病与衰老报告或讨论可复核的学术证据。", "summary": "该节点将神经退行性疾病与衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1650" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 311 轮补录：神经退行性疾病与衰老；待本地复核。；日期补齐：Crossref 2004-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-930", "title": "《Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises》论文发表", "date_start": "2003-01-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与动脉韧性报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与动脉韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1651" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 312 轮补录：心血管衰老与动脉韧性；待本地复核。；日期补齐：Crossref 2003-01-28 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-931", "title": "《Accelerated peripheral vascular aging in pseudoxanthoma elasticum – proof of concept for arterial calcification-induced cardiovascular disease》论文发表", "date_start": "2019-02-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与动脉韧性报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与动脉韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1652" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 312 轮补录：心血管衰老与动脉韧性；待本地复核。；日期补齐：Crossref 2019-02-11 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-932", "title": "《Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises》论文发表", "date_start": "2003-01-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与动脉韧性报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与动脉韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1653" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 312 轮补录：心血管衰老与动脉韧性；待本地复核。；日期补齐：Crossref 2003-01-07 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-933", "title": "《Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises》论文发表", "date_start": "2003-01-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与动脉韧性报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与动脉韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1654" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 312 轮补录：心血管衰老与动脉韧性；待本地复核。；日期补齐：Crossref 2003-01-21 (published-print, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-934", "title": "《Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice》论文发表", "date_start": "2016-11-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕心血管衰老与动脉韧性报告或讨论可复核的学术证据。", "summary": "该节点将心血管衰老与动脉韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1655" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 312 轮补录：心血管衰老与动脉韧性；待本地复核。；日期补齐：Crossref 2016-11-22 (published-online, day, v3)", "created_at": "2026-08-07T07:37:27Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-935", "title": "《Abdominal obesity and metabolic syndrome》论文发表", "date_start": "2006-12-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕代谢综合征与长寿报告或讨论可复核的学术证据。", "summary": "该节点将代谢综合征与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1656" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 313 轮补录：代谢综合征与长寿；待本地复核。；日期补齐：Crossref 2006-12-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-936", "title": "《Metabolic Networks of Longevity》论文发表", "date_start": "2010-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕代谢综合征与长寿报告或讨论可复核的学术证据。", "summary": "该节点将代谢综合征与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1657" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 313 轮补录：代谢综合征与长寿；待本地复核。；日期补齐：Crossref 2010-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-937", "title": "《Metabolic Control of Longevity》论文发表", "date_start": "2016-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕代谢综合征与长寿报告或讨论可复核的学术证据。", "summary": "该节点将代谢综合征与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1658" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 313 轮补录：代谢综合征与长寿；待本地复核。；日期补齐：Crossref 2016-08 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-938", "title": "《Promoting Health and Longevity through Diet: From Model Organisms to Humans》论文发表", "date_start": "2015-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕代谢综合征与长寿报告或讨论可复核的学术证据。", "summary": "该节点将代谢综合征与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1659" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 313 轮补录：代谢综合征与长寿；待本地复核。；日期补齐：Crossref 2015-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-939", "title": "《Sirtuins as potential targets for metabolic syndrome》论文发表", "date_start": "2006-12-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕代谢综合征与长寿报告或讨论可复核的学术证据。", "summary": "该节点将代谢综合征与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1660" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 313 轮补录：代谢综合征与长寿；待本地复核。；日期补齐：Crossref 2006-12-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-940", "title": "《The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study》论文发表", "date_start": "2006-10-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肌肉骨骼健康与功能报告或讨论可复核的学术证据。", "summary": "该节点将肌肉骨骼健康与功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1661" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 314 轮补录：肌肉骨骼健康与功能；待本地复核。；日期补齐：Crossref 2006-10-01 (published-print, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-941", "title": "《Dynapenia and Aging: An Update》论文发表", "date_start": "2011-03-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肌肉骨骼健康与功能报告或讨论可复核的学术证据。", "summary": "该节点将肌肉骨骼健康与功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1662" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 314 轮补录：肌肉骨骼健康与功能；待本地复核。；日期补齐：Crossref 2011-03-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-942", "title": "《Criteria for Clinically Relevant Weakness and Low Lean Mass and Their Longitudinal Association With Incident Mobility Impairment and Mortality: The Foundation for the National Institutes of Health (FNIH) Sarcopenia Project》论文发表", "date_start": "2014-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肌肉骨骼健康与功能报告或讨论可复核的学术证据。", "summary": "该节点将肌肉骨骼健康与功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1663" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 314 轮补录：肌肉骨骼健康与功能；待本地复核。；日期补齐：Crossref 2014-04-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-943", "title": "《Lower-Extremity Function in Persons over the Age of 70 Years as a Predictor of Subsequent Disability》论文发表", "date_start": "1995-03-02", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肌肉骨骼健康与功能报告或讨论可复核的学术证据。", "summary": "该节点将肌肉骨骼健康与功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1664" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 314 轮补录：肌肉骨骼健康与功能；待本地复核。；日期补齐：Crossref 1995-03-02 (published-print, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-944", "title": "《Gait Speed and Survival in Older Adults》论文发表", "date_start": "2011-01-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕肌肉骨骼健康与功能报告或讨论可复核的学术证据。", "summary": "该节点将肌肉骨骼健康与功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1665" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 314 轮补录：肌肉骨骼健康与功能；待本地复核。；日期补齐：Crossref 2011-01-05 (published-print, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-945", "title": "《Fertility Preservation in Women》论文发表", "date_start": "2017-10-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生殖健康与未来选择权报告或讨论可复核的学术证据。", "summary": "该节点将生殖健康与未来选择权的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1666" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 315 轮补录：生殖健康与未来选择权；待本地复核。；日期补齐：Crossref 2017-10-26 (published-print, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-946", "title": "《Feasibility of ovarian stimulation and oocyte cryopreservation for fertility preservation in female children》论文发表", "date_start": "2013-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生殖健康与未来选择权报告或讨论可复核的学术证据。", "summary": "该节点将生殖健康与未来选择权的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1667" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 315 轮补录：生殖健康与未来选择权；待本地复核。；日期补齐：Crossref 2013-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-947", "title": "《Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update》论文发表", "date_start": "2018-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生殖健康与未来选择权报告或讨论可复核的学术证据。", "summary": "该节点将生殖健康与未来选择权的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1668" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 315 轮补录：生殖健康与未来选择权；待本地复核。；日期补齐：Crossref 2018-07-01 (published-print, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-948", "title": "《Ovary cryopreservation and transplantation for fertility preservation》论文发表", "date_start": "2011-12-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生殖健康与未来选择权报告或讨论可复核的学术证据。", "summary": "该节点将生殖健康与未来选择权的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1669" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 315 轮补录：生殖健康与未来选择权；待本地复核。；日期补齐：Crossref 2011-12-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-949", "title": "《The efficacy and safety of fertility preservation using ovarian stimulation and oocyte or embryo cryopreservation in female cancer patients》论文发表", "date_start": "2011-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生殖健康与未来选择权报告或讨论可复核的学术证据。", "summary": "该节点将生殖健康与未来选择权的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1670" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 315 轮补录：生殖健康与未来选择权；待本地复核。；日期补齐：Crossref 2011-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-950", "title": "《Scratching the surface of skin development》论文发表", "date_start": "2007-02-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕皮肤屏障与组织修复报告或讨论可复核的学术证据。", "summary": "该节点将皮肤屏障与组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1671" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 316 轮补录：皮肤屏障与组织修复；待本地复核。；日期补齐：Crossref 2007-02-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-951", "title": "《Wound repair and regeneration》论文发表", "date_start": "2008-05-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕皮肤屏障与组织修复报告或讨论可复核的学术证据。", "summary": "该节点将皮肤屏障与组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1672" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 316 轮补录：皮肤屏障与组织修复；待本地复核。；日期补齐：Crossref 2008-05-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-952", "title": "《Wound repair and regeneration: Mechanisms, signaling, and translation》论文发表", "date_start": "2014-12-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕皮肤屏障与组织修复报告或讨论可复核的学术证据。", "summary": "该节点将皮肤屏障与组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1673" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 316 轮补录：皮肤屏障与组织修复；待本地复核。；日期补齐：Crossref 2014-12-03 (published-print, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-953", "title": "《Wound repair: a showcase for cell plasticity and migration》论文发表", "date_start": "2016-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕皮肤屏障与组织修复报告或讨论可复核的学术证据。", "summary": "该节点将皮肤屏障与组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1674" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 316 轮补录：皮肤屏障与组织修复；待本地复核。；日期补齐：Crossref 2016-10 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-954", "title": "《Skin Cell Heterogeneity in Development, Wound Healing, and Cancer》论文发表", "date_start": "2018-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕皮肤屏障与组织修复报告或讨论可复核的学术证据。", "summary": "该节点将皮肤屏障与组织修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1675" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 316 轮补录：皮肤屏障与组织修复；待本地复核。；日期补齐：Crossref 2018-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-955", "title": "《Therapy of Severe Heatshock in Combination With Multiple Organ Dysfunction With Continuous Renal Replacement Therapy》论文发表", "date_start": "2015-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官衰竭与替代疗法报告或讨论可复核的学术证据。", "summary": "该节点将器官衰竭与替代疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1676" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 317 轮补录：器官衰竭与替代疗法；待本地复核。；日期补齐：Crossref 2015-08 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-956", "title": "《Management of pediatric liver failure with therapeutic plasma exchange and continuous renal replacement therapy: A retrospective observational study》论文发表", "date_start": "2024-05-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官衰竭与替代疗法报告或讨论可复核的学术证据。", "summary": "该节点将器官衰竭与替代疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1677" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 317 轮补录：器官衰竭与替代疗法；待本地复核。；日期补齐：Crossref 2024-05-10 (published-print, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-957", "title": "《Organ failure》论文发表", "date_start": "2004-01-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官衰竭与替代疗法报告或讨论可复核的学术证据。", "summary": "该节点将器官衰竭与替代疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1678" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 317 轮补录：器官衰竭与替代疗法；待本地复核。；日期补齐：Crossref 2004-01-01 (published-print, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-958", "title": "《Replacement therapy, not recreational tonic》论文发表", "date_start": "2004-11-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官衰竭与替代疗法报告或讨论可复核的学术证据。", "summary": "该节点将器官衰竭与替代疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1679" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 317 轮补录：器官衰竭与替代疗法；待本地复核。；日期补齐：Crossref 2004-11-24 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-959", "title": "《Friendly fire from organ failure》论文发表", "date_start": "2015-12-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕器官衰竭与替代疗法报告或讨论可复核的学术证据。", "summary": "该节点将器官衰竭与替代疗法的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1680" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 317 轮补录：器官衰竭与替代疗法；待本地复核。；日期补齐：Crossref 2015-12-17 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-960", "title": "《What will be the cost of a genetically‐engineered pig organ for clinical xenotransplantation?》论文发表", "date_start": "2020-06-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕异种移植与器官工程报告或讨论可复核的学术证据。", "summary": "该节点将异种移植与器官工程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1681" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 318 轮补录：异种移植与器官工程；待本地复核。；日期补齐：Crossref 2020-06-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-961", "title": "《Will donor‐derived neoplasia be problematic after clinical pig organ or cell xenotransplantation?》论文发表", "date_start": "2018-11-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕异种移植与器官工程报告或讨论可复核的学术证据。", "summary": "该节点将异种移植与器官工程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1682" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 318 轮补录：异种移植与器官工程；待本地复核。；日期补齐：Crossref 2018-11-09 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-962", "title": "《Solid organ xenotransplantation at the interface between research and clinical development: Regulatory aspects》论文发表", "date_start": "2020-06-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕异种移植与器官工程报告或讨论可复核的学术证据。", "summary": "该节点将异种移植与器官工程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1683" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 318 轮补录：异种移植与器官工程；待本地复核。；日期补齐：Crossref 2020-06-05 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-963", "title": "《IXA Plenary Session 1: Update on Preclinical Life‐Supporting Organ Xenotransplantation – Current Strategies to Remaining Obstacles》论文发表", "date_start": "2013-09-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕异种移植与器官工程报告或讨论可复核的学术证据。", "summary": "该节点将异种移植与器官工程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1684" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 318 轮补录：异种移植与器官工程；待本地复核。；日期补齐：Crossref 2013-09-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-964", "title": "《Low anti‐pig antibody levels are key to the success of solid organ xenotransplantation: But is this sufficient?》论文发表", "date_start": "2017-10-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕异种移植与器官工程报告或讨论可复核的学术证据。", "summary": "该节点将异种移植与器官工程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1685" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 318 轮补录：异种移植与器官工程；待本地复核。；日期补齐：Crossref 2017-10-25 (published-online, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-965", "title": "《Novel approaches for cryopreservation: Meeting the needs for cellular therapy, tissue, and organ preservation》论文发表", "date_start": "2016-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕冷冻保存与生物停滞报告或讨论可复核的学术证据。", "summary": "该节点将冷冻保存与生物停滞的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1686" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 319 轮补录：冷冻保存与生物停滞；待本地复核。；日期补齐：Crossref 2016-12 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-966", "title": "《The Organ Preservation Alliance: Accelerating research to enable breakthroughs in organ cryopreservation》论文发表", "date_start": "2016-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕冷冻保存与生物停滞报告或讨论可复核的学术证据。", "summary": "该节点将冷冻保存与生物停滞的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1687" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 319 轮补录：冷冻保存与生物停滞；待本地复核。；日期补齐：Crossref 2016-12 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-967", "title": "《Importance and safety of autologous sperm cryopreservation for fertility preservation in young male patients with cancer》论文发表", "date_start": "2020-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕冷冻保存与生物停滞报告或讨论可复核的学术证据。", "summary": "该节点将冷冻保存与生物停滞的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1688" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 319 轮补录：冷冻保存与生物停滞；待本地复核。；日期补齐：Crossref 2020-04 (published-online, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-968", "title": "《Cryopreservation of immature ovaries for fertility preservation》论文发表", "date_start": "2025-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕冷冻保存与生物停滞报告或讨论可复核的学术证据。", "summary": "该节点将冷冻保存与生物停滞的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1689" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 319 轮补录：冷冻保存与生物停滞；待本地复核。；日期补齐：Crossref 2025-12 (published-print, month, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-969", "title": "《Cryopreservation of porcine embryos》论文发表", "date_start": "1995-03-30", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕冷冻保存与生物停滞报告或讨论可复核的学术证据。", "summary": "该节点将冷冻保存与生物停滞的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1690" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 319 轮补录：冷冻保存与生物停滞；待本地复核。；日期补齐：Crossref 1995-03-30 (published-print, day, v3)", "created_at": "2026-08-07T07:37:28Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-398", "title": "《Immortality improves cell reprogramming》论文发表", "date_start": "2009-08-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕数字永生与意识上传报告或讨论可复核的学术证据。", "summary": "该节点将数字永生与意识上传的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1691" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 320 轮补录：数字永生与意识上传；待本地复核。；日期补齐：Crossref 2009-08-09 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-399", "title": "《FDA and immortality》论文发表", "date_start": "1991-06", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕数字永生与意识上传报告或讨论可复核的学术证据。", "summary": "该节点将数字永生与意识上传的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1692" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 320 轮补录：数字永生与意识上传；待本地复核。；日期补齐：Crossref 1991-06 (published-print, month, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-400", "title": "《In pursuit of data immortality》论文发表", "date_start": "2022-04-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕数字永生与意识上传报告或讨论可复核的学术证据。", "summary": "该节点将数字永生与意识上传的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1693" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 320 轮补录：数字永生与意识上传；待本地复核。；日期补齐：Crossref 2022-04-04 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-401", "title": "《Immortality of a kind》论文发表", "date_start": "2007-03-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕数字永生与意识上传报告或讨论可复核的学术证据。", "summary": "该节点将数字永生与意识上传的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1694" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 320 轮补录：数字永生与意识上传；待本地复核。；日期补齐：Crossref 2007-03-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-402", "title": "《The quest for immortality》论文发表", "date_start": "2006-12-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "thought", "claim": "该文献围绕数字永生与意识上传报告或讨论可复核的学术证据。", "summary": "该节点将数字永生与意识上传的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1695" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞维护、再生医学与生物停滞", "notes": "第 320 轮补录：数字永生与意识上传；待本地复核。；日期补齐：Crossref 2006-12-06 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-970", "title": "《Cognitive enhancement drug may also cause addiction》论文发表", "date_start": "2009-03-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕认知增强与神经接口报告或讨论可复核的学术证据。", "summary": "该节点将认知增强与神经接口的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1696" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 321 轮补录：认知增强与神经接口；待本地复核。；日期补齐：Crossref 2009-03-17 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-971", "title": "《Age-related cognitive decline: Can neural stem cells help us?》论文发表", "date_start": "2012-03-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕认知增强与神经接口报告或讨论可复核的学术证据。", "summary": "该节点将认知增强与神经接口的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1697" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 321 轮补录：认知增强与神经接口；待本地复核。；日期补齐：Crossref 2012-03-31 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-972", "title": "《Much ado about cognitive enhancement》论文发表", "date_start": "2009-01-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕认知增强与神经接口报告或讨论可复核的学术证据。", "summary": "该节点将认知增强与神经接口的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1698" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 321 轮补录：认知增强与神经接口；待本地复核。；日期补齐：Crossref 2009-01-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-973", "title": "《Brain–machine interface reveals the origin of a widely used neural signal》论文发表", "date_start": "2026-04-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕认知增强与神经接口报告或讨论可复核的学术证据。", "summary": "该节点将认知增强与神经接口的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1699" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 321 轮补录：认知增强与神经接口；待本地复核。；日期补齐：Crossref 2026-04-15 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-974", "title": "《Neural interface translates thoughts into type》论文发表", "date_start": "2021-05-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕认知增强与神经接口报告或讨论可复核的学术证据。", "summary": "该节点将认知增强与神经接口的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1700" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 321 轮补录：认知增强与神经接口；待本地复核。；日期补齐：Crossref 2021-05-12 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-975", "title": "《High-performance brain-to-text communication via handwriting》论文发表", "date_start": "2021-05-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口与运动重建报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口与运动重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1701" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 322 轮补录：脑机接口与运动重建；待本地复核。；日期补齐：Crossref 2021-05-12 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-976", "title": "《Neuronal ensemble control of prosthetic devices by a human with tetraplegia》论文发表", "date_start": "2006-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口与运动重建报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口与运动重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1702" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 322 轮补录：脑机接口与运动重建；待本地复核。；日期补齐：Crossref 2006-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-977", "title": "《High-performance neuroprosthetic control by an individual with tetraplegia》论文发表", "date_start": "2013-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口与运动重建报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口与运动重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1703" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 322 轮补录：脑机接口与运动重建；待本地复核。；日期补齐：Crossref 2013-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-978", "title": "《Fully Implanted Brain–Computer Interface in a Locked-In Patient with ALS》论文发表", "date_start": "2016-11-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口与运动重建报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口与运动重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1704" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 322 轮补录：脑机接口与运动重建；待本地复核。；日期补齐：Crossref 2016-11-24 (published-print, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-979", "title": "《High performance communication by people with paralysis using an intracortical brain-computer interface》论文发表", "date_start": "2017-02-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕脑机接口与运动重建报告或讨论可复核的学术证据。", "summary": "该节点将脑机接口与运动重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1705" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 322 轮补录：脑机接口与运动重建；待本地复核。；日期补齐：Crossref 2017-02-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-980", "title": "《Highly accurate protein structure prediction with AlphaFold》论文发表", "date_start": "2021-07-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕人工智能药物发现报告或讨论可复核的学术证据。", "summary": "该节点将人工智能药物发现的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1706" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 323 轮补录：人工智能药物发现；待本地复核。；日期补齐：Crossref 2021-07-15 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-981", "title": "《Deep learning enables rapid identification of potent DDR1 kinase inhibitors》论文发表", "date_start": "2019-09-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕人工智能药物发现报告或讨论可复核的学术证据。", "summary": "该节点将人工智能药物发现的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1707" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 323 轮补录：人工智能药物发现；待本地复核。；日期补齐：Crossref 2019-09-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-982", "title": "《Rethinking drug design in the artificial intelligence era》论文发表", "date_start": "2019-12-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕人工智能药物发现报告或讨论可复核的学术证据。", "summary": "该节点将人工智能药物发现的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1708" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 323 轮补录：人工智能药物发现；待本地复核。；日期补齐：Crossref 2019-12-04 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-983", "title": "《Drug discovery with explainable artificial intelligence》论文发表", "date_start": "2020-10-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕人工智能药物发现报告或讨论可复核的学术证据。", "summary": "该节点将人工智能药物发现的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1709" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 323 轮补录：人工智能药物发现；待本地复核。；日期补齐：Crossref 2020-10-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-984", "title": "《Dual use of artificial-intelligence-powered drug discovery》论文发表", "date_start": "2022-03-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕人工智能药物发现报告或讨论可复核的学术证据。", "summary": "该节点将人工智能药物发现的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1710" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 323 轮补录：人工智能药物发现；待本地复核。；日期补齐：Crossref 2022-03-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:29Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-985", "title": "《Autonomous elemental characterization enabled by a low cost robotic platform built upon a generalized software architecture》论文发表", "date_start": "2026", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕AI科学自动化报告或讨论可复核的学术证据。", "summary": "该节点将AI科学自动化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1711" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 324 轮补录：AI科学自动化；待本地复核。；日期补齐：Crossref 2026 (published-online, year, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-986", "title": "《ChemCrow: Augmenting Large-Language Models with Chemistry Tools》论文发表", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕AI科学自动化报告或讨论可复核的学术证据。", "summary": "该节点将AI科学自动化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1712" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 324 轮补录：AI科学自动化；待本地复核。", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-07T07:37:32Z" }, { "event_id": "HIT-TEC-987", "title": "《A mobile robotic chemist》论文发表", "date_start": "2020-07-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕AI科学自动化报告或讨论可复核的学术证据。", "summary": "该节点将AI科学自动化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1713" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 324 轮补录：AI科学自动化；待本地复核。；日期补齐：Crossref 2020-07-08 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-988", "title": "《A robotic platform for flow synthesis of organic compounds informed by AI planning》论文发表", "date_start": "2019-08-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕AI科学自动化报告或讨论可复核的学术证据。", "summary": "该节点将AI科学自动化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1714" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 324 轮补录：AI科学自动化；待本地复核。；日期补齐：Crossref 2019-08-09 (published-print, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-989", "title": "《Electronic polymer discovery through adaptive AI-guided autonomous experimentation》论文发表", "date_start": "2025-12-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕AI科学自动化报告或讨论可复核的学术证据。", "summary": "该节点将AI科学自动化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1715" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 324 轮补录：AI科学自动化；待本地复核。；日期补齐：Crossref 2025-12-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-990", "title": "《Molecular biology: RNA repair》论文发表", "date_start": "2009-02-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米医学与分子修复报告或讨论可复核的学术证据。", "summary": "该节点将纳米医学与分子修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1716" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 325 轮补录：纳米医学与分子修复；待本地复核。；日期补齐：Crossref 2009-02-04 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-991", "title": "《Molecular Mechanism of Transcription-Repair Coupling》论文发表", "date_start": "1993-04-02", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米医学与分子修复报告或讨论可复核的学术证据。", "summary": "该节点将纳米医学与分子修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1717" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 325 轮补录：纳米医学与分子修复；待本地复核。；日期补齐：Crossref 1993-04-02 (published-print, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-992", "title": "《From start to finish—a molecular link in wound repair》论文发表", "date_start": "2022-02-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米医学与分子修复报告或讨论可复核的学术证据。", "summary": "该节点将纳米医学与分子修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1718" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 325 轮补录：纳米医学与分子修复；待本地复核。；日期补齐：Crossref 2022-02-11 (published-print, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-993", "title": "《Molecular Pathologies: DNA Repair and Mutagenesis . Errol C. Friedberg, Graham C. Walker, and Wolfram Siede. ASM Press, Washington, DC, 1995. xviii, 698 pp., iiius., + plates. $79. New edition of DNA Repair .》论文发表", "date_start": "1995-12", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米医学与分子修复报告或讨论可复核的学术证据。", "summary": "该节点将纳米医学与分子修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1719" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 325 轮补录：纳米医学与分子修复；待本地复核。；日期补齐：Crossref 1995-12 (published-print, month, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-994", "title": "《Draft guidelines for nanomedicine unveiled》论文发表", "date_start": "2011-09-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕纳米医学与分子修复报告或讨论可复核的学术证据。", "summary": "该节点将纳米医学与分子修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1720" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 325 轮补录：纳米医学与分子修复；待本地复核。；日期补齐：Crossref 2011-09-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-995", "title": "《Programming circuitry for synthetic biology》论文发表", "date_start": "2016-03-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕合成生物学与细胞编程报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学与细胞编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1721" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 326 轮补录：合成生物学与细胞编程；待本地复核。；日期补齐：Crossref 2016-03-31 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-996", "title": "《Synthetic biology: How best to build a cell》论文发表", "date_start": "2014-05-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕合成生物学与细胞编程报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学与细胞编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1722" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 326 轮补录：合成生物学与细胞编程；待本地复核。；日期补齐：Crossref 2014-05-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-997", "title": "《A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions》论文发表", "date_start": "2012-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕合成生物学与细胞编程报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学与细胞编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1723" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 326 轮补录：合成生物学与细胞编程；待本地复核。；日期补齐：Crossref 2012-08 (published-print, month, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-998", "title": "《Programming self-organizing multicellular structures with synthetic cell-cell signaling》论文发表", "date_start": "2018-07-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕合成生物学与细胞编程报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学与细胞编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1724" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 326 轮补录：合成生物学与细胞编程；待本地复核。；日期补齐：Crossref 2018-07-13 (published-print, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-999", "title": "《Synthetic Biology Looks Good on Paper》论文发表", "date_start": "2014-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕合成生物学与细胞编程报告或讨论可复核的学术证据。", "summary": "该节点将合成生物学与细胞编程的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1725" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 326 轮补录：合成生物学与细胞编程；待本地复核。；日期补齐：Crossref 2014-11 (published-print, month, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1000", "title": "《Sickle Cell Disease Approvals Include First CRISPR Gene Editing Therapy》论文发表", "date_start": "2024-01-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因编辑与治疗报告或讨论可复核的学术证据。", "summary": "该节点将基因编辑与治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1726" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 327 轮补录：基因编辑与治疗；待本地复核。；日期补齐：Crossref 2024-01-23 (published-print, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1001", "title": "《HIV overcomes CRISPR gene-editing attack》论文发表", "date_start": "2016-04-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因编辑与治疗报告或讨论可复核的学术证据。", "summary": "该节点将基因编辑与治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1727" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 327 轮补录：基因编辑与治疗；待本地复核。；日期补齐：Crossref 2016-04-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1002", "title": "《CRISPR gene editing produces unwanted DNA deletions》论文发表", "date_start": "2018-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因编辑与治疗报告或讨论可复核的学术证据。", "summary": "该节点将基因编辑与治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1728" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 327 轮补录：基因编辑与治疗；待本地复核。；日期补齐：Crossref 2018-07-16 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1003", "title": "《CRISPR gene-editing system unleashed on RNA》论文发表", "date_start": "2016-06-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因编辑与治疗报告或讨论可复核的学术证据。", "summary": "该节点将基因编辑与治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1729" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 327 轮补录：基因编辑与治疗；待本地复核。；日期补齐：Crossref 2016-06-03 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1004", "title": "《Powerful enzyme could make CRISPR gene-editing more versatile》论文发表", "date_start": "2018-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因编辑与治疗报告或讨论可复核的学术证据。", "summary": "该节点将基因编辑与治疗的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1730" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 327 轮补录：基因编辑与治疗；待本地复核。；日期补齐：Crossref 2018-02-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1005", "title": "《Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing》论文发表", "date_start": "2016-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕表观遗传编辑与状态重写报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传编辑与状态重写的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1731" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 328 轮补录：表观遗传编辑与状态重写；待本地复核。；日期补齐：Crossref 2016-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1006", "title": "《A Metabolic Throttle Regulates the Epigenetic State of rDNA》论文发表", "date_start": "2008-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕表观遗传编辑与状态重写报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传编辑与状态重写的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1732" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 328 轮补录：表观遗传编辑与状态重写；待本地复核。；日期补齐：Crossref 2008-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1007", "title": "《Epigenetic editing makes its mark》论文发表", "date_start": "2026-07-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕表观遗传编辑与状态重写报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传编辑与状态重写的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1733" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 328 轮补录：表观遗传编辑与状态重写；待本地复核。；日期补齐：Crossref 2026-07-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1008", "title": "《‘Epigenetic’ editing cuts cholesterol in mice》论文发表", "date_start": "2024-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕表观遗传编辑与状态重写报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传编辑与状态重写的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1734" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 328 轮补录：表观遗传编辑与状态重写；待本地复核。；日期补齐：Crossref 2024-02-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1009", "title": "《Rewriting the genetic bond: Gene editing and our understanding of genetic parenthood》论文发表", "date_start": "2022-11-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕表观遗传编辑与状态重写报告或讨论可复核的学术证据。", "summary": "该节点将表观遗传编辑与状态重写的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1735" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 328 轮补录：表观遗传编辑与状态重写；待本地复核。；日期补齐：Crossref 2022-11-09 (published-online, day, v3)", "created_at": "2026-08-07T07:37:32Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1010", "title": "《LIFE SCIENCE TECHNOLOGIES: This Is Your Brain: Mapping the Connectome》论文发表", "date_start": "2013-01-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕脑保存与连接组重建报告或讨论可复核的学术证据。", "summary": "该节点将脑保存与连接组重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1736" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 329 轮补录：脑保存与连接组重建；待本地复核。；日期补齐：Crossref 2013-01-18 (published-print, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1011", "title": "《Identify connectome between genotypes and brain network phenotypes via deep self-reconstruction sparse canonical correlation analysis》论文发表", "date_start": "2022-02-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕脑保存与连接组重建报告或讨论可复核的学术证据。", "summary": "该节点将脑保存与连接组重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1737" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 329 轮补录：脑保存与连接组重建；待本地复核。；日期补齐：Crossref 2022-02-10 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1012", "title": "《Transcriptome, connectome and neuromodulation of the primate brain》论文发表", "date_start": "2022-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕脑保存与连接组重建报告或讨论可复核的学术证据。", "summary": "该节点将脑保存与连接组重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1738" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 329 轮补录：脑保存与连接组重建；待本地复核。；日期补齐：Crossref 2022-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1013", "title": "《From Connections to Function: The Mouse Brain Connectome Atlas》论文发表", "date_start": "2014-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕脑保存与连接组重建报告或讨论可复核的学术证据。", "summary": "该节点将脑保存与连接组重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1739" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 329 轮补录：脑保存与连接组重建；待本地复核。；日期补齐：Crossref 2014-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1014", "title": "《Language in the aging brain: The network dynamics of cognitive decline and preservation》论文发表", "date_start": "2014-10-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "suspension", "event_type": "technology", "claim": "该文献围绕脑保存与连接组重建报告或讨论可复核的学术证据。", "summary": "该节点将脑保存与连接组重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1740" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 329 轮补录：脑保存与连接组重建；待本地复核。；日期补齐：Crossref 2014-10-31 (published-print, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-403", "title": "《Moral Bioenhancement Through Memory-editing: A Risk for Identity and Authenticity?》论文发表", "date_start": "2017-03-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕记忆编辑与身份连续性报告或讨论可复核的学术证据。", "summary": "该节点将记忆编辑与身份连续性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1741" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 330 轮补录：记忆编辑与身份连续性；待本地复核。；日期补齐：Crossref 2017-03-24 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-404", "title": "《Memory of myself: Autobiographical memory and identity in Alzheimer's disease》论文发表", "date_start": "2004-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕记忆编辑与身份连续性报告或讨论可复核的学术证据。", "summary": "该节点将记忆编辑与身份连续性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1742" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 330 轮补录：记忆编辑与身份连续性；待本地复核。；日期补齐：Crossref 2004-01 (published-print, month, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-405", "title": "《Episodic memory reconsolidation: Updating or source confusion?》论文发表", "date_start": "2009-06-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕记忆编辑与身份连续性报告或讨论可复核的学术证据。", "summary": "该节点将记忆编辑与身份连续性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1743" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 330 轮补录：记忆编辑与身份连续性；待本地复核。；日期补齐：Crossref 2009-06-22 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-406", "title": "《Opening the reconsolidation window using the mind’s eye: Extinction training during reconsolidation disrupts fear memory expression following mental imagery reactivation》论文发表", "date_start": "2019-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕记忆编辑与身份连续性报告或讨论可复核的学术证据。", "summary": "该节点将记忆编辑与身份连续性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1744" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 330 轮补录：记忆编辑与身份连续性；待本地复核。；日期补齐：Crossref 2019-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-407", "title": "《Sleep Loss Immediately After Fear Memory Reactivation Attenuates Fear Memory Reconsolidation》论文发表", "date_start": "2020-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕记忆编辑与身份连续性报告或讨论可复核的学术证据。", "summary": "该节点将记忆编辑与身份连续性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1745" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 330 轮补录：记忆编辑与身份连续性；待本地复核。；日期补齐：Crossref 2020-01 (published-print, month, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-408", "title": "《Reasons and Persons》论文发表", "date_start": "2003-11-01", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体连续性建模报告或讨论可复核的学术证据。", "summary": "该节点将主体连续性建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1746" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 331 轮补录：主体连续性建模；待本地复核。；日期补齐：Crossref 2003-11-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-409", "title": "《Personal Identity》论文发表", "date_start": "1971-01", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体连续性建模报告或讨论可复核的学术证据。", "summary": "该节点将主体连续性建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1747" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 331 轮补录：主体连续性建模；待本地复核。；日期补齐：Crossref 1971-01 (published-print, month, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-410", "title": "《The Personal Identity Dilemma for Transhumanism》论文发表", "date_start": "2024-10-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体连续性建模报告或讨论可复核的学术证据。", "summary": "该节点将主体连续性建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1748" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 331 轮补录：主体连续性建模；待本地复核。；日期补齐：Crossref 2024-10-11 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-411", "title": "《Extended mind, functionalism and personal identity》论文发表", "date_start": "2018-05-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体连续性建模报告或讨论可复核的学术证据。", "summary": "该节点将主体连续性建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1749" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 331 轮补录：主体连续性建模；待本地复核。；日期补齐：Crossref 2018-05-05 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-412", "title": "《James Giles on Personal Identity》论文发表", "date_start": "2009-01-30", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕主体连续性建模报告或讨论可复核的学术证据。", "summary": "该节点将主体连续性建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1750" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 331 轮补录：主体连续性建模；待本地复核。；日期补齐：Crossref 2009-01-30 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-413", "title": "《Prions' great escape》论文发表", "date_start": "2008-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度理论的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1751" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 332 轮补录：长寿逃逸速度理论；待本地复核。；日期补齐：Crossref 2008-07-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-414", "title": "《Longevity genes challenged》论文发表", "date_start": "2011-09-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度理论的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1752" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 332 轮补录：长寿逃逸速度理论；待本地复核。；日期补齐：Crossref 2011-09-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-415", "title": "《Mars rover plans its escape》论文发表", "date_start": "2009-11-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度理论的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1753" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 332 轮补录：长寿逃逸速度理论；待本地复核。；日期补齐：Crossref 2009-11-05 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-416", "title": "《T Cell Responses and Viral Escape》论文发表", "date_start": "1998-05", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度理论的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1754" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 332 轮补录：长寿逃逸速度理论；待本地复核。；日期补齐：Crossref 1998-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-417", "title": "《Escape from UNEP?》论文发表", "date_start": "1997-09-04", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕长寿逃逸速度理论报告或讨论可复核的学术证据。", "summary": "该节点将长寿逃逸速度理论的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1755" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 332 轮补录：长寿逃逸速度理论；待本地复核。；日期补齐：Crossref 1997-09-04 (published-print, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-418", "title": "《Gravitational Red-Shift in Nuclear Resonance》论文发表", "date_start": "1959-11-01", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕未来等待与时间差分报告或讨论可复核的学术证据。", "summary": "该节点将未来等待与时间差分的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1756" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 333 轮补录：未来等待与时间差分；待本地复核。；日期补齐：Crossref 1959-11-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-419", "title": "《Test of Relativistic Gravitation with a Space-Borne Hydrogen Maser》论文发表", "date_start": "1980-12-29", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕未来等待与时间差分报告或讨论可复核的学术证据。", "summary": "该节点将未来等待与时间差分的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1757" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 333 轮补录：未来等待与时间差分；待本地复核。；日期补齐：Crossref 1980-12-29 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-420", "title": "《Relativity in the Global Positioning System》论文发表", "date_start": "2003-01-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕未来等待与时间差分报告或讨论可复核的学术证据。", "summary": "该节点将未来等待与时间差分的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1758" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 333 轮补录：未来等待与时间差分；待本地复核。；日期补齐：Crossref 2003-01-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-421", "title": "《Zur Elektrodynamik bewegter Körper》论文发表", "date_start": "2006-03-10", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕未来等待与时间差分报告或讨论可复核的学术证据。", "summary": "该节点将未来等待与时间差分的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1759" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 333 轮补录：未来等待与时间差分；待本地复核。；日期补齐：Crossref 2006-03-10 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-422", "title": "《Non-Turing Computations Via Malament–Hogarth Space-Times》论文发表", "date_start": "2002-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕未来等待与时间差分报告或讨论可复核的学术证据。", "summary": "该节点将未来等待与时间差分的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1760" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 333 轮补录：未来等待与时间差分；待本地复核。；日期补齐：Crossref 2002-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-057", "title": "《Existential Risk Prevention as Global Priority》论文发表", "date_start": "2013-03-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕技术风险治理报告或讨论可复核的学术证据。", "summary": "该节点将技术风险治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1761" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 334 轮补录：技术风险治理；待本地复核。；日期补齐：Crossref 2013-03-27 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-058", "title": "《The Malicious Use of Artificial Intelligence: Forecasting, Prevention, and Mitigation》论文发表", "date_start": "2018", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕技术风险治理报告或讨论可复核的学术证据。", "summary": "该节点将技术风险治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1762" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 334 轮补录：技术风险治理；待本地复核。", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-07T07:37:33Z" }, { "event_id": "HIT-POL-059", "title": "《An Overview of Catastrophic AI Risks》论文发表", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕技术风险治理报告或讨论可复核的学术证据。", "summary": "该节点将技术风险治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1763" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 334 轮补录：技术风险治理；待本地复核。", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-07T07:37:33Z" }, { "event_id": "HIT-POL-060", "title": "《The AI Risk Repository: A Comprehensive Meta-Review, Database, and Risk Taxonomy of AI Risks》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕技术风险治理报告或讨论可复核的学术证据。", "summary": "该节点将技术风险治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1764" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 334 轮补录：技术风险治理；待本地复核。", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-07T07:37:33Z" }, { "event_id": "HIT-POL-061", "title": "《The Precipice: Existential Risk and the Future of Humanity》论文发表", "date_start": "2020", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕技术风险治理报告或讨论可复核的学术证据。", "summary": "该节点将技术风险治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1765" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 334 轮补录：技术风险治理；待本地复核。", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-07T07:37:33Z" }, { "event_id": "HIT-TEC-1015", "title": "《DNA methylation age of human tissues and cell types》论文发表", "date_start": "2013-12-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕健康寿命测量报告或讨论可复核的学术证据。", "summary": "该节点将健康寿命测量的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1766" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 335 轮补录：健康寿命测量；待本地复核。；日期补齐：Crossref 2013-12-10 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1016", "title": "《An epigenetic biomarker of aging for lifespan and healthspan》论文发表", "date_start": "2018-04-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕健康寿命测量报告或讨论可复核的学术证据。", "summary": "该节点将健康寿命测量的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1767" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 335 轮补录：健康寿命测量；待本地复核。；日期补齐：Crossref 2018-04-18 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1017", "title": "《DNA methylation GrimAge strongly predicts lifespan and healthspan》论文发表", "date_start": "2019-01-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕健康寿命测量报告或讨论可复核的学术证据。", "summary": "该节点将健康寿命测量的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1768" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 335 轮补录：健康寿命测量；待本地复核。；日期补齐：Crossref 2019-01-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1018", "title": "《Quantification of biological aging in young adults》论文发表", "date_start": "2015-07-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕健康寿命测量报告或讨论可复核的学术证据。", "summary": "该节点将健康寿命测量的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1769" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 335 轮补录：健康寿命测量；待本地复核。；日期补齐：Crossref 2015-07-06 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1019", "title": "《Early prediction of healthy ageing and age-related diseases using blood protein biomarkers》论文发表", "date_start": "2025-01-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕健康寿命测量报告或讨论可复核的学术证据。", "summary": "该节点将健康寿命测量的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1770" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 335 轮补录：健康寿命测量；待本地复核。；日期补齐：Crossref 2025-01-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:33Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-062", "title": "《Metformin as a Tool to Target Aging》论文发表", "date_start": "2016-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕临床转化与监管报告或讨论可复核的学术证据。", "summary": "该节点将临床转化与监管的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1771" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 336 轮补录：临床转化与监管；待本地复核。；日期补齐：Crossref 2016-06 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-063", "title": "《Cellular Senescence: A Translational Perspective》论文发表", "date_start": "2017-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕临床转化与监管报告或讨论可复核的学术证据。", "summary": "该节点将临床转化与监管的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1772" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 336 轮补录：临床转化与监管；待本地复核。；日期补齐：Crossref 2017-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-064", "title": "《A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup》论文发表", "date_start": "2018-08-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕临床转化与监管报告或讨论可复核的学术证据。", "summary": "该节点将临床转化与监管的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1773" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 336 轮补录：临床转化与监管；待本地复核。；日期补齐：Crossref 2018-08-27 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-065", "title": "《Geroscience: The Intersection of Basic Aging Biology, Chronic Disease, and Health》论文发表", "date_start": "2019-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕临床转化与监管报告或讨论可复核的学术证据。", "summary": "该节点将临床转化与监管的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1774" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 336 轮补录：临床转化与监管；待本地复核。；日期补齐：Crossref 2019-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-066", "title": "《Targeting Aging with Metformin (TAME)》论文发表", "date_start": "2022-05-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕临床转化与监管报告或讨论可复核的学术证据。", "summary": "该节点将临床转化与监管的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1775" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 336 轮补录：临床转化与监管；待本地复核。；日期补齐：Crossref 2022-05-24 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-INS-076", "title": "《Flu study faces shake-up over industry funding》论文发表", "date_start": "2007-03-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "该文献围绕长寿产业与资金报告或讨论可复核的学术证据。", "summary": "该节点将长寿产业与资金的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1776" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 337 轮补录：长寿产业与资金；待本地复核。；日期补齐：Crossref 2007-03-26 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-INS-077", "title": "《Funding cuts favour industry links》论文发表", "date_start": "1994-02-17", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "该文献围绕长寿产业与资金报告或讨论可复核的学术证据。", "summary": "该节点将长寿产业与资金的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1777" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 337 轮补录：长寿产业与资金；待本地复核。；日期补齐：Crossref 1994-02-17 (published-print, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-INS-078", "title": "《Industry funding doesn't influence our reports》论文发表", "date_start": "2004-11-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "该文献围绕长寿产业与资金报告或讨论可复核的学术证据。", "summary": "该节点将长寿产业与资金的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1778" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 337 轮补录：长寿产业与资金；待本地复核。；日期补齐：Crossref 2004-11-03 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-INS-079", "title": "《Industry funding of UK universities static》论文发表", "date_start": "1993-09-02", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "该文献围绕长寿产业与资金报告或讨论可复核的学术证据。", "summary": "该节点将长寿产业与资金的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1779" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 337 轮补录：长寿产业与资金；待本地复核。；日期补齐：Crossref 1993-09-02 (published-print, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-INS-080", "title": "《Scientists split over tobacco industry research funding》论文发表", "date_start": "1996-09-05", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "institution", "claim": "该文献围绕长寿产业与资金报告或讨论可复核的学术证据。", "summary": "该节点将长寿产业与资金的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1780" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 337 轮补录：长寿产业与资金；待本地复核。；日期补齐：Crossref 1996-09-05 (published-print, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-067", "title": "《Dementia prevention, intervention, and care》论文发表", "date_start": "2017-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕全球健康与老龄化政策报告或讨论可复核的学术证据。", "summary": "该节点将全球健康与老龄化政策的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1781" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 338 轮补录：全球健康与老龄化政策；待本地复核。；日期补齐：Crossref 2017-12 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-068", "title": "《Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019》论文发表", "date_start": "2020-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕全球健康与老龄化政策报告或讨论可复核的学术证据。", "summary": "该节点将全球健康与老龄化政策的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1782" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 338 轮补录：全球健康与老龄化政策；待本地复核。；日期补齐：Crossref 2020-10 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-069", "title": "《The World Report on Ageing and Health》论文发表", "date_start": "2016-03-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕全球健康与老龄化政策报告或讨论可复核的学术证据。", "summary": "该节点将全球健康与老龄化政策的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1783" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 338 轮补录：全球健康与老龄化政策；待本地复核。；日期补齐：Crossref 2016-03-18 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-070", "title": "《The World report on ageing and health: a policy framework for healthy ageing》论文发表", "date_start": "2016-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕全球健康与老龄化政策报告或讨论可复核的学术证据。", "summary": "该节点将全球健康与老龄化政策的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1784" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 338 轮补录：全球健康与老龄化政策；待本地复核。；日期补齐：Crossref 2016-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-423", "title": "《Adopt universal standards for study adaptation to boost health, education and social-science research》论文发表", "date_start": "2024-04-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕教育与社会适应报告或讨论可复核的学术证据。", "summary": "该节点将教育与社会适应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1786" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 339 轮补录：教育与社会适应；待本地复核。；日期补齐：Crossref 2024-04-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-424", "title": "《Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour》论文发表", "date_start": "2015-05-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕教育与社会适应报告或讨论可复核的学术证据。", "summary": "该节点将教育与社会适应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1787" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 339 轮补录：教育与社会适应；待本地复核。；日期补齐：Crossref 2015-05-25 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-425", "title": "《Education: Embed social awareness in science curricula》论文发表", "date_start": "2014-01-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕教育与社会适应报告或讨论可复核的学术证据。", "summary": "该节点将教育与社会适应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1788" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 339 轮补录：教育与社会适应；待本地复核。；日期补齐：Crossref 2014-01-22 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-426", "title": "《Derepressing Nuclear Receptors for Metabolic Adaptation》论文发表", "date_start": "2011-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕教育与社会适应报告或讨论可复核的学术证据。", "summary": "该节点将教育与社会适应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1789" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 339 轮补录：教育与社会适应；待本地复核。；日期补齐：Crossref 2011-11 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-427", "title": "《Checkpoint Adaptation》论文发表", "date_start": "2004-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕教育与社会适应报告或讨论可复核的学术证据。", "summary": "该节点将教育与社会适应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1790" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 339 轮补录：教育与社会适应；待本地复核。；日期补齐：Crossref 2004-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-428", "title": "《Quantum computing: physics–AI collaboration quashes quantum errors》论文发表", "date_start": "2024-11-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕劳动力与AI协作报告或讨论可复核的学术证据。", "summary": "该节点将劳动力与AI协作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1791" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 340 轮补录：劳动力与AI协作；待本地复核。；日期补齐：Crossref 2024-11-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-429", "title": "《Dual Arms of Adaptive Immunity: Division of Labor and Collaboration between B and T Cells》论文发表", "date_start": "2019-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕劳动力与AI协作报告或讨论可复核的学术证据。", "summary": "该节点将劳动力与AI协作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1792" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 340 轮补录：劳动力与AI协作；待本地复核。；日期补齐：Crossref 2019-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-430", "title": "《ChatGPT and science: the AI system was a force in 2023 — for good and bad》论文发表", "date_start": "2023-12-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕劳动力与AI协作报告或讨论可复核的学术证据。", "summary": "该节点将劳动力与AI协作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1793" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 340 轮补录：劳动力与AI协作；待本地复核。；日期补齐：Crossref 2023-12-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-431", "title": "《Promoter Cleavage: A TopoIIβ and PARP-1 Collaboration》论文发表", "date_start": "2006-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕劳动力与AI协作报告或讨论可复核的学术证据。", "summary": "该节点将劳动力与AI协作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1794" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 340 轮补录：劳动力与AI协作；待本地复核。；日期补齐：Crossref 2006-06 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-432", "title": "《Division of Labor by Dendritic Cells》论文发表", "date_start": "2007-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕劳动力与AI协作报告或讨论可复核的学术证据。", "summary": "该节点将劳动力与AI协作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1795" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知扩展、数字主体与智能治理", "notes": "第 340 轮补录：劳动力与AI协作；待本地复核。；日期补齐：Crossref 2007-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-433", "title": "《Environmental Governance for the Anthropocene? Social-Ecological Systems, Resilience, and Collaborative Learning》论文发表", "date_start": "2017-07-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕环境健康与生态韧性报告或讨论可复核的学术证据。", "summary": "该节点将环境健康与生态韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1796" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 341 轮补录：环境健康与生态韧性；待本地复核。；日期补齐：Crossref 2017-07-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-434", "title": "《Tropical forest tells a tale of ecological resilience and human tragedy》论文发表", "date_start": "2018-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕环境健康与生态韧性报告或讨论可复核的学术证据。", "summary": "该节点将环境健康与生态韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1797" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 341 轮补录：环境健康与生态韧性；待本地复核。；日期补齐：Crossref 2018-07-16 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-435", "title": "《Public health in the age of longevity interventions: from prevention to system-wide resilience》论文发表", "date_start": "2026-05-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕环境健康与生态韧性报告或讨论可复核的学术证据。", "summary": "该节点将环境健康与生态韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1798" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 341 轮补录：环境健康与生态韧性；待本地复核。；日期补齐：Crossref 2026-05-18 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-436", "title": "《COVID-19: boost mental-health resilience》论文发表", "date_start": "2022-01-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕环境健康与生态韧性报告或讨论可复核的学术证据。", "summary": "该节点将环境健康与生态韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1799" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 341 轮补录：环境健康与生态韧性；待本地复核。；日期补齐：Crossref 2022-01-04 (published-online, day, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-437", "title": "《Mitochondrial activity tunes nociceptor resilience to excitotoxicity》论文发表", "date_start": "2025-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕环境健康与生态韧性报告或讨论可复核的学术证据。", "summary": "该节点将环境健康与生态韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1800" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 341 轮补录：环境健康与生态韧性；待本地复核。；日期补齐：Crossref 2025-11 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-438", "title": "《Bidirectional linkage between a long-term energy system and a short-term power market model》论文发表", "date_start": "2020-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕能源基础设施与长期文明报告或讨论可复核的学术证据。", "summary": "该节点将能源基础设施与长期文明的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1801" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 342 轮补录：能源基础设施与长期文明；待本地复核。；日期补齐：Crossref 2020-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-439", "title": "《Intra-regional renewable energy resource variability in long-term energy system planning》论文发表", "date_start": "2022-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕能源基础设施与长期文明报告或讨论可复核的学术证据。", "summary": "该节点将能源基础设施与长期文明的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1802" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 342 轮补录：能源基础设施与长期文明；待本地复核。；日期补齐：Crossref 2022-04 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-440", "title": "《Energy-economic-environmental analysis and multi-objective optimization of district heating and cooling system with long-term and short-term thermal storage》论文发表", "date_start": "2026-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕能源基础设施与长期文明报告或讨论可复核的学术证据。", "summary": "该节点将能源基础设施与长期文明的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1803" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 342 轮补录：能源基础设施与长期文明；待本地复核。；日期补齐：Crossref 2026-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-441", "title": "《Short-term solar and wind variability in long-term energy system models - A European case study》论文发表", "date_start": "2020-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕能源基础设施与长期文明报告或讨论可复核的学术证据。", "summary": "该节点将能源基础设施与长期文明的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1804" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 342 轮补录：能源基础设施与长期文明；待本地复核。；日期补齐：Crossref 2020-10 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-442", "title": "《Long-term renewable energy technology valuation using system dynamics and Monte Carlo simulation: Photovoltaic technology case》论文发表", "date_start": "2014-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕能源基础设施与长期文明报告或讨论可复核的学术证据。", "summary": "该节点将能源基础设施与长期文明的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1805" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 342 轮补录：能源基础设施与长期文明；待本地复核。；日期补齐：Crossref 2014-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:34Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-443", "title": "《Seven Food System Metrics of Sustainable Nutrition Security》论文发表", "date_start": "2016-02-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕食物系统与营养安全报告或讨论可复核的学术证据。", "summary": "该节点将食物系统与营养安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1806" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 343 轮补录：食物系统与营养安全；待本地复核。；日期补齐：Crossref 2016-02-23 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-444", "title": "《Risk Challenges and Their Impact on the Sustainable Food Security System: Lessons Learned from the COVID-19 Pandemic》论文发表", "date_start": "2024-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕食物系统与营养安全报告或讨论可复核的学术证据。", "summary": "该节点将食物系统与营养安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1807" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 343 轮补录：食物系统与营养安全；待本地复核。；日期补齐：Crossref 2024-12-31 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-445", "title": "《An Integrated Global Food and Energy Security System Dynamics Model for Addressing Systemic Risk》论文发表", "date_start": "2019-07-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕食物系统与营养安全报告或讨论可复核的学术证据。", "summary": "该节点将食物系统与营养安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1808" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 343 轮补录：食物系统与营养安全；待本地复核。；日期补齐：Crossref 2019-07-23 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-446", "title": "《The Coupling Coordination Degree and Constraints of the Water–Energy–Food Security System: A Case Study in Northeast China》论文发表", "date_start": "2026-02-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕食物系统与营养安全报告或讨论可复核的学术证据。", "summary": "该节点将食物系统与营养安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1809" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 343 轮补录：食物系统与营养安全；待本地复核。；日期补齐：Crossref 2026-02-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-447", "title": "《Crisis Response and Supervision System for Food Security: A Comparative Analysis between Mainland China and Taiwan》论文发表", "date_start": "2020-04-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕食物系统与营养安全报告或讨论可复核的学术证据。", "summary": "该节点将食物系统与营养安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1810" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 343 轮补录：食物系统与营养安全；待本地复核。；日期补齐：Crossref 2020-04-10 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-448", "title": "《Burden of disease from inadequate water, sanitation and hygiene for selected adverse health outcomes: An updated analysis with a focus on low- and middle-income countries》论文发表", "date_start": "2019-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕水资源与卫生设施报告或讨论可复核的学术证据。", "summary": "该节点将水资源与卫生设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1811" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 344 轮补录：水资源与卫生设施；待本地复核。；日期补齐：Crossref 2019-06 (published-print, month, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-449", "title": "《Impact of drinking water, sanitation and handwashing with soap on childhood diarrhoeal disease: updated meta‐analysis and meta‐regression》论文发表", "date_start": "2018-04-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕水资源与卫生设施报告或讨论可复核的学术证据。", "summary": "该节点将水资源与卫生设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1812" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 344 轮补录：水资源与卫生设施；待本地复核。；日期补齐：Crossref 2018-04-23 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-450", "title": "《Effectiveness of a rural sanitation programme on diarrhoea, soil-transmitted helminth infection, and child malnutrition in Odisha, India: a cluster-randomised trial》论文发表", "date_start": "2014-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕水资源与卫生设施报告或讨论可复核的学术证据。", "summary": "该节点将水资源与卫生设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1813" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 344 轮补录：水资源与卫生设施；待本地复核。；日期补齐：Crossref 2014-11 (published-print, month, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-451", "title": "《Interventions to improve water quality for preventing diarrhoea》论文发表", "date_start": "2015-10-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕水资源与卫生设施报告或讨论可复核的学术证据。", "summary": "该节点将水资源与卫生设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1814" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 344 轮补录：水资源与卫生设施；待本地复核。；日期补齐：Crossref 2015-10-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-452", "title": "《Effect of washing hands with soap on diarrhoea risk in the community: a systematic review》论文发表", "date_start": "2003-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕水资源与卫生设施报告或讨论可复核的学术证据。", "summary": "该节点将水资源与卫生设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1815" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 344 轮补录：水资源与卫生设施；待本地复核。；日期补齐：Crossref 2003-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-453", "title": "《Housing and Health Inequalities: Review and Prospects for Research》论文发表", "date_start": "2010-07-14", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕住房与建成环境报告或讨论可复核的学术证据。", "summary": "该节点将住房与建成环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1816" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 345 轮补录：住房与建成环境；待本地复核。；日期补齐：Crossref 2010-07-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-454", "title": "《Housing and inequalities in health》论文发表", "date_start": "2002-09-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕住房与建成环境报告或讨论可复核的学术证据。", "summary": "该节点将住房与建成环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1817" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 345 轮补录：住房与建成环境；待本地复核。；日期补齐：Crossref 2002-09-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-455", "title": "《Housing and health inequalities: A synthesis of systematic reviews of interventions aimed at different pathways linking housing and health》论文发表", "date_start": "2011-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕住房与建成环境报告或讨论可复核的学术证据。", "summary": "该节点将住房与建成环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1818" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 345 轮补录：住房与建成环境；待本地复核。；日期补齐：Crossref 2011-01 (published-print, month, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-456", "title": "《Housing improvements for health and associated socio-economic outcomes》论文发表", "date_start": "2013-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕住房与建成环境报告或讨论可复核的学术证据。", "summary": "该节点将住房与建成环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1819" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 345 轮补录：住房与建成环境；待本地复核。；日期补齐：Crossref 2013-02-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-457", "title": "《Housing and Health: Time Again for Public Health Action》论文发表", "date_start": "2002-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕住房与建成环境报告或讨论可复核的学术证据。", "summary": "该节点将住房与建成环境的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1820" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 345 轮补录：住房与建成环境；待本地复核。；日期补齐：Crossref 2002-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-458", "title": "《Astounding bat mobility》论文发表", "date_start": "2001-02-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕交通与移动基础设施报告或讨论可复核的学术证据。", "summary": "该节点将交通与移动基础设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1821" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 346 轮补录：交通与移动基础设施；待本地复核。；日期补齐：Crossref 2001-02-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-459", "title": "《Protein Mobility within the Nucleus—What Are the Right Moves?》论文发表", "date_start": "2001-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕交通与移动基础设施报告或讨论可复核的学术证据。", "summary": "该节点将交通与移动基础设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1822" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 346 轮补录：交通与移动基础设施；待本地复核。；日期补齐：Crossref 2001-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-460", "title": "《Protein Mobility within the Nucleus—What Are the Right Moves?》论文发表", "date_start": "2001-03-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕交通与移动基础设施报告或讨论可复核的学术证据。", "summary": "该节点将交通与移动基础设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1823" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 346 轮补录：交通与移动基础设施；待本地复核。；日期补齐：Crossref 2001-03-09 (published-print, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-461", "title": "《Retrohoming: cDNA-Mediated Mobility of Group II Introns Requires a Catalytic RNA》论文发表", "date_start": "1996-01", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕交通与移动基础设施报告或讨论可复核的学术证据。", "summary": "该节点将交通与移动基础设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1824" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 346 轮补录：交通与移动基础设施；待本地复核。；日期补齐：Crossref 1996-01 (published-print, month, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-462", "title": "《The Lateral Organization and Mobility of Plasma Membrane Components》论文发表", "date_start": "2019-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕交通与移动基础设施报告或讨论可复核的学术证据。", "summary": "该节点将交通与移动基础设施的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1825" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 346 轮补录：交通与移动基础设施；待本地复核。；日期补齐：Crossref 2019-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-463", "title": "《Internet skills and the digital divide》论文发表", "date_start": "2010-12-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕数字基础设施与连接报告或讨论可复核的学术证据。", "summary": "该节点将数字基础设施与连接的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1826" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 347 轮补录：数字基础设施与连接；待本地复核。；日期补齐：Crossref 2010-12-06 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-464", "title": "《Second-Level Digital Divide: Differences in People's Online Skills》论文发表", "date_start": "2002-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕数字基础设施与连接报告或讨论可复核的学术证据。", "summary": "该节点将数字基础设施与连接的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1827" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 347 轮补录：数字基础设施与连接；待本地复核。；日期补齐：Crossref 2002-04-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-465", "title": "《Any Thing for Anyone? A New Digital Divide in Internet‐of‐Things Skills》论文发表", "date_start": "2018-02-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕数字基础设施与连接报告或讨论可复核的学术证据。", "summary": "该节点将数字基础设施与连接的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1828" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 347 轮补录：数字基础设施与连接；待本地复核。；日期补齐：Crossref 2018-02-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-466", "title": "《Digital Inclusion as Health Care — Supporting Health Care Equity with Digital-Infrastructure Initiatives》论文发表", "date_start": "2022-03-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕数字基础设施与连接报告或讨论可复核的学术证据。", "summary": "该节点将数字基础设施与连接的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1829" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 347 轮补录：数字基础设施与连接；待本地复核。；日期补齐：Crossref 2022-03-24 (published-print, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-467", "title": "《Relationship Between Internet Use and Cognitive Function Among Middle-Aged and Older Chinese Adults: 5-Year Longitudinal Study》论文发表", "date_start": "2024-12-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕数字基础设施与连接报告或讨论可复核的学术证据。", "summary": "该节点将数字基础设施与连接的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1830" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 347 轮补录：数字基础设施与连接；待本地复核。；日期补齐：Crossref 2024-12-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-072", "title": "《Israel split on rights to genetic privacy》论文发表", "date_start": "1998-07-16", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕隐私、数据与主体权利报告或讨论可复核的学术证据。", "summary": "该节点将隐私、数据与主体权利的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1831" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 348 轮补录：隐私、数据与主体权利；待本地复核。；日期补齐：Crossref 1998-07-16 (published-print, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-073", "title": "《China’s souped-up data privacy laws deter researchers》论文发表", "date_start": "2023-05-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕隐私、数据与主体权利报告或讨论可复核的学术证据。", "summary": "该节点将隐私、数据与主体权利的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1832" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 348 轮补录：隐私、数据与主体权利；待本地复核。；日期补齐：Crossref 2023-05-25 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-074", "title": "《Data sharing threatens privacy》论文发表", "date_start": "2007-10-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕隐私、数据与主体权利报告或讨论可复核的学术证据。", "summary": "该节点将隐私、数据与主体权利的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1833" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 348 轮补录：隐私、数据与主体权利；待本地复核。；日期补齐：Crossref 2007-10-10 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-075", "title": "《Intellectual property and data privacy: the hidden risks of AI》论文发表", "date_start": "2024-09-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕隐私、数据与主体权利报告或讨论可复核的学术证据。", "summary": "该节点将隐私、数据与主体权利的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1834" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 348 轮补录：隐私、数据与主体权利；待本地复核。；日期补齐：Crossref 2024-09-04 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-076", "title": "《Protect privacy of mobile data》论文发表", "date_start": "2014-10-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕隐私、数据与主体权利报告或讨论可复核的学术证据。", "summary": "该节点将隐私、数据与主体权利的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1835" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 348 轮补录：隐私、数据与主体权利；待本地复核。；日期补齐：Crossref 2014-10-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-468", "title": "《Ethics guidelines for human enhancement R&D》论文发表", "date_start": "2022-11-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕伦理与人类增强边界报告或讨论可复核的学术证据。", "summary": "该节点将伦理与人类增强边界的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1836" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 349 轮补录：伦理与人类增强边界；待本地复核。；日期补齐：Crossref 2022-11-25 (published-print, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-469", "title": "《Ethics and the human genome》论文发表", "date_start": "1991-06-20", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕伦理与人类增强边界报告或讨论可复核的学术证据。", "summary": "该节点将伦理与人类增强边界的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1837" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 349 轮补录：伦理与人类增强边界；待本地复核。；日期补齐：Crossref 1991-06-20 (published-print, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-470", "title": "《Human-subjects research: The ethics squad》论文发表", "date_start": "2014-10-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕伦理与人类增强边界报告或讨论可复核的学术证据。", "summary": "该节点将伦理与人类增强边界的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1838" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 349 轮补录：伦理与人类增强边界；待本地复核。；日期补齐：Crossref 2014-10-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-471", "title": "《Take stock of research ethics in human genome editing》论文发表", "date_start": "2017-09-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕伦理与人类增强边界报告或讨论可复核的学术证据。", "summary": "该节点将伦理与人类增强边界的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1839" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 349 轮补录：伦理与人类增强边界；待本地复核。；日期补齐：Crossref 2017-09-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-472", "title": "《Audio long read: Hybrid brains – the ethics of transplanting human neurons into animals》论文发表", "date_start": "2022-08-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕伦理与人类增强边界报告或讨论可复核的学术证据。", "summary": "该节点将伦理与人类增强边界的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1840" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 349 轮补录：伦理与人类增强边界；待本地复核。；日期补齐：Crossref 2022-08-26 (published-online, day, v3)", "created_at": "2026-08-07T07:37:35Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-473", "title": "《Happiness is everything, or is it? Explorations on the meaning of psychological well-being.》论文发表", "date_start": "1989-12", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕心理韧性与意义报告或讨论可复核的学术证据。", "summary": "该节点将心理韧性与意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1841" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 350 轮补录：心理韧性与意义；待本地复核。；日期补齐：Crossref 1989-12 (published-online, month, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-474", "title": "《The meaning in life questionnaire: Assessing the presence of and search for meaning in life.》论文发表", "date_start": "2006-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕心理韧性与意义报告或讨论可复核的学术证据。", "summary": "该节点将心理韧性与意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1842" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 350 轮补录：心理韧性与意义；待本地复核。；日期补齐：Crossref 2006-01 (published-online, month, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-475", "title": "《Purpose in Life as a Predictor of Mortality Across Adulthood》论文发表", "date_start": "2014-05-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕心理韧性与意义报告或讨论可复核的学术证据。", "summary": "该节点将心理韧性与意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1843" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 350 轮补录：心理韧性与意义；待本地复核。；日期补齐：Crossref 2014-05-08 (published-online, day, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-476", "title": "《Purpose in Life Is Associated With Mortality Among Community-Dwelling Older Persons》论文发表", "date_start": "2009-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕心理韧性与意义报告或讨论可复核的学术证据。", "summary": "该节点将心理韧性与意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1844" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 350 轮补录：心理韧性与意义；待本地复核。；日期补齐：Crossref 2009-06 (published-print, month, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-477", "title": "《The Contours of Positive Human Health》论文发表", "date_start": "2009-11-19", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕心理韧性与意义报告或讨论可复核的学术证据。", "summary": "该节点将心理韧性与意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1845" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 350 轮补录：心理韧性与意义；待本地复核。；日期补齐：Crossref 2009-11-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-478", "title": "《Social Networks and Longevity: How Social Ties Influence Healthy Aging》论文发表", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕社会支持网络与长寿报告或讨论可复核的学术证据。", "summary": "该节点将社会支持网络与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1846" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 351 轮补录：社会支持网络与长寿；待本地复核。；日期补齐：Crossref 2023 (published-online, year, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-479", "title": "《Watch how social inequality impacts everything from health to longevity》论文发表", "date_start": "2020-06-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕社会支持网络与长寿报告或讨论可复核的学术证据。", "summary": "该节点将社会支持网络与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1847" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 351 轮补录：社会支持网络与长寿；待本地复核。；日期补齐：Crossref 2020-06-05 (published-print, day, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-480", "title": "《Support cells in the brain promote longevity》论文发表", "date_start": "2020-01-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕社会支持网络与长寿报告或讨论可复核的学术证据。", "summary": "该节点将社会支持网络与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1848" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 351 轮补录：社会支持网络与长寿；待本地复核。；日期补齐：Crossref 2020-01-24 (published-print, day, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-481", "title": "《Death Anxiety in Older Adults: The Role of Perceived Social Support and Psychological Hardiness Mediated by Resilience among Older Adults in Tehran》论文发表", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕社会支持网络与长寿报告或讨论可复核的学术证据。", "summary": "该节点将社会支持网络与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1849" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 351 轮补录：社会支持网络与长寿；待本地复核。；日期补齐：Crossref 2023 (published-online, year, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-482", "title": "《Black scientist network celebrates successes — but calls for more support》论文发表", "date_start": "2021-06-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕社会支持网络与长寿报告或讨论可复核的学术证据。", "summary": "该节点将社会支持网络与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1850" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 351 轮补录：社会支持网络与长寿；待本地复核。；日期补齐：Crossref 2021-06-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-483", "title": "《Caregiving as a Risk Factor for Mortality》论文发表", "date_start": "1999-12-15", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕家庭照护与长期护理报告或讨论可复核的学术证据。", "summary": "该节点将家庭照护与长期护理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1851" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 352 轮补录：家庭照护与长期护理；待本地复核。；日期补齐：Crossref 1999-12-15 (published-print, day, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-484", "title": "《Caregiver Burden》论文发表", "date_start": "2014-03-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕家庭照护与长期护理报告或讨论可复核的学术证据。", "summary": "该节点将家庭照护与长期护理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1852" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 352 轮补录：家庭照护与长期护理；待本地复核。；日期补齐：Crossref 2014-03-12 (published-print, day, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-485", "title": "《Differences between caregivers and noncaregivers in psychological health and physical health: A meta-analysis.》论文发表", "date_start": "2003", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕家庭照护与长期护理报告或讨论可复核的学术证据。", "summary": "该节点将家庭照护与长期护理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1853" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 352 轮补录：家庭照护与长期护理；待本地复核。；日期补齐：Crossref 2003 (published-online, year, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-486", "title": "《Caregiving, Mortality, and Mobility Decline<subtitle>The Health, Aging, and Body Composition (Health ABC) Study</subtitle>》论文发表", "date_start": "2008-10-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕家庭照护与长期护理报告或讨论可复核的学术证据。", "summary": "该节点将家庭照护与长期护理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1854" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 352 轮补录：家庭照护与长期护理；待本地复核。；日期补齐：Crossref 2008-10-27 (published-print, day, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-487", "title": "《Family caregiving and emotional strain: associations with quality of life in a large national sample of middle-aged and older adults》论文发表", "date_start": "2009-05-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕家庭照护与长期护理报告或讨论可复核的学术证据。", "summary": "该节点将家庭照护与长期护理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1855" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 352 轮补录：家庭照护与长期护理；待本地复核。；日期补齐：Crossref 2009-05-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:36Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-488", "title": "《Subjective wellbeing, health, and ageing》论文发表", "date_start": "2015-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕精神健康与生命意义报告或讨论可复核的学术证据。", "summary": "该节点将精神健康与生命意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1856" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 353 轮补录：精神健康与生命意义；待本地复核。；日期补齐：Crossref 2015-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-489", "title": "《The Lancet Commission on ending stigma and discrimination in mental health》论文发表", "date_start": "2022-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕精神健康与生命意义报告或讨论可复核的学术证据。", "summary": "该节点将精神健康与生命意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1857" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 353 轮补录：精神健康与生命意义；待本地复核。；日期补齐：Crossref 2022-10 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-490", "title": "《Effect of Purpose in Life on the Relation Between Alzheimer Disease Pathologic Changes on Cognitive Function in Advanced Age》论文发表", "date_start": "2012-05-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕精神健康与生命意义报告或讨论可复核的学术证据。", "summary": "该节点将精神健康与生命意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1858" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 353 轮补录：精神健康与生命意义；待本地复核。；日期补齐：Crossref 2012-05-01 (published-print, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-491", "title": "《Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019》论文发表", "date_start": "2022-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕精神健康与生命意义报告或讨论可复核的学术证据。", "summary": "该节点将精神健康与生命意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1859" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 353 轮补录：精神健康与生命意义；待本地复核。；日期补齐：Crossref 2022-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-492", "title": "《Interpersonal Processes in Depression》论文发表", "date_start": "2013-03-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕精神健康与生命意义报告或讨论可复核的学术证据。", "summary": "该节点将精神健康与生命意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1860" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 353 轮补录：精神健康与生命意义；待本地复核。；日期补齐：Crossref 2013-03-28 (published-print, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1020", "title": "《The Protective Power of Cognitive Reserve: Examining White Matter Integrity and Cognitive Function in the Aging Brain for Sustainable Cognitive Health》论文发表", "date_start": "2023-07-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕认知老化与脑韧性报告或讨论可复核的学术证据。", "summary": "该节点将认知老化与脑韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1861" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 354 轮补录：认知老化与脑韧性；待本地复核。；日期补齐：Crossref 2023-07-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1021", "title": "《Plasticity of the aging brain: New directions in cognitive neuroscience》论文发表", "date_start": "2014-10-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕认知老化与脑韧性报告或讨论可复核的学术证据。", "summary": "该节点将认知老化与脑韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1862" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 354 轮补录：认知老化与脑韧性；待本地复核。；日期补齐：Crossref 2014-10-31 (published-print, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1022", "title": "《Speak, memory: on cognitive reserve and brain resilience》论文发表", "date_start": "2021-06-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕认知老化与脑韧性报告或讨论可复核的学术证据。", "summary": "该节点将认知老化与脑韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1863" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 354 轮补录：认知老化与脑韧性；待本地复核。；日期补齐：Crossref 2021-06-11 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1023", "title": "《Cognitive resilience and severe Alzheimer’s disease neuropathology》论文发表", "date_start": "2023", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕认知老化与脑韧性报告或讨论可复核的学术证据。", "summary": "该节点将认知老化与脑韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1864" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 354 轮补录：认知老化与脑韧性；待本地复核。；日期补齐：Crossref 2023 (published-print, year, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1024", "title": "《MILD COGNITIVE IMPAIRMENT: AGING TO ALZHEIMER'S DISEASE》论文发表", "date_start": "2004-01-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕认知老化与脑韧性报告或讨论可复核的学术证据。", "summary": "该节点将认知老化与脑韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1865" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 354 轮补录：认知老化与脑韧性；待本地复核。；日期补齐：Crossref 2004-01-01 (published-print, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1025", "title": "《Improving fluid intelligence with training on working memory》论文发表", "date_start": "2008-05-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕注意力与执行功能报告或讨论可复核的学术证据。", "summary": "该节点将注意力与执行功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1866" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 355 轮补录：注意力与执行功能；待本地复核。；日期补齐：Crossref 2008-05-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1026", "title": "《Putting brain training to the test》论文发表", "date_start": "2010-04-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕注意力与执行功能报告或讨论可复核的学术证据。", "summary": "该节点将注意力与执行功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1867" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 355 轮补录：注意力与执行功能；待本地复核。；日期补齐：Crossref 2010-04-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1027", "title": "《Training and plasticity of working memory》论文发表", "date_start": "2010-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕注意力与执行功能报告或讨论可复核的学术证据。", "summary": "该节点将注意力与执行功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1868" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 355 轮补录：注意力与执行功能；待本地复核。；日期补齐：Crossref 2010-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1028", "title": "《Executive Functions》论文发表", "date_start": "2013-01-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕注意力与执行功能报告或讨论可复核的学术证据。", "summary": "该节点将注意力与执行功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1869" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 355 轮补录：注意力与执行功能；待本地复核。；日期补齐：Crossref 2013-01-03 (published-print, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1029", "title": "《Do “Brain-Training” Programs Work?》论文发表", "date_start": "2016-10-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕注意力与执行功能报告或讨论可复核的学术证据。", "summary": "该节点将注意力与执行功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1870" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 355 轮补录：注意力与执行功能；待本地复核。；日期补齐：Crossref 2016-10-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1030", "title": "《Genetic and environmental contributions to the acquisition of a motor skill》论文发表", "date_start": "1996-11", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕学习科学与技能积累报告或讨论可复核的学术证据。", "summary": "该节点将学习科学与技能积累的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1871" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 356 轮补录：学习科学与技能积累；待本地复核。；日期补齐：Crossref 1996-11 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1031", "title": "《The time course of learning a visual skill》论文发表", "date_start": "1993-09", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕学习科学与技能积累报告或讨论可复核的学术证据。", "summary": "该节点将学习科学与技能积累的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1872" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 356 轮补录：学习科学与技能积累；待本地复核。；日期补齐：Crossref 1993-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1032", "title": "《Covert skill learning in a cortical-basal ganglia circuit》论文发表", "date_start": "2012-05-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕学习科学与技能积累报告或讨论可复核的学术证据。", "summary": "该节点将学习科学与技能积累的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1873" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 356 轮补录：学习科学与技能积累；待本地复核。；日期补齐：Crossref 2012-05-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1033", "title": "《Functional MRI evidence for adult motor cortex plasticity during motor skill learning》论文发表", "date_start": "1995-09", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕学习科学与技能积累报告或讨论可复核的学术证据。", "summary": "该节点将学习科学与技能积累的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1874" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 356 轮补录：学习科学与技能积累；待本地复核。；日期补齐：Crossref 1995-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1034", "title": "《Blended Learning Improves Science Education》论文发表", "date_start": "2015-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕学习科学与技能积累报告或讨论可复核的学术证据。", "summary": "该节点将学习科学与技能积累的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1875" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 356 轮补录：学习科学与技能积累；待本地复核。；日期补齐：Crossref 2015-08 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-493", "title": "《The Creativity Code The Creativity Code: Art and Innovation in the Age of AI Marcus du Sautoy Belknap Press, 2019. 320 pp.》论文发表", "date_start": "2019-05-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕创造力与创新系统报告或讨论可复核的学术证据。", "summary": "该节点将创造力与创新系统的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1876" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 357 轮补录：创造力与创新系统；待本地复核。；日期补齐：Crossref 2019-05-31 (published-print, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-494", "title": "《A latent capacity for evolutionary innovation through exaptation in metabolic systems》论文发表", "date_start": "2013-07-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕创造力与创新系统报告或讨论可复核的学术证据。", "summary": "该节点将创造力与创新系统的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1877" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 357 轮补录：创造力与创新系统；待本地复核。；日期补齐：Crossref 2013-07-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-495", "title": "《Mysteries and Miseries of Creativity》论文发表", "date_start": "2016-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕创造力与创新系统报告或讨论可复核的学术证据。", "summary": "该节点将创造力与创新系统的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1878" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 357 轮补录：创造力与创新系统；待本地复核。；日期补齐：Crossref 2016-01 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-496", "title": "《How jazz boosts my creativity in physics》论文发表", "date_start": "2026-05-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕创造力与创新系统报告或讨论可复核的学术证据。", "summary": "该节点将创造力与创新系统的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1879" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 357 轮补录：创造力与创新系统；待本地复核。；日期补齐：Crossref 2026-05-29 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-497", "title": "《The creativity machine》论文发表", "date_start": "2006-03-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "thought", "claim": "该文献围绕创造力与创新系统报告或讨论可复核的学术证据。", "summary": "该节点将创造力与创新系统的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1880" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 357 轮补录：创造力与创新系统；待本地复核。；日期补齐：Crossref 2006-03-22 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-498", "title": "《Transhumanism Without Transindividuation in the Age Without Epochality: Stiegler, Vice, and Radical Human Enhancement》论文发表", "date_start": "2026-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕人类增强与超人类主义报告或讨论可复核的学术证据。", "summary": "该节点将人类增强与超人类主义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1881" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 358 轮补录：人类增强与超人类主义；待本地复核。；日期补齐：Crossref 2026-07-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-499", "title": "《Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex》论文发表", "date_start": "1994-08", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕人类增强与超人类主义报告或讨论可复核的学术证据。", "summary": "该节点将人类增强与超人类主义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1882" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 358 轮补录：人类增强与超人类主义；待本地复核。；日期补齐：Crossref 1994-08 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-500", "title": "《Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax》论文发表", "date_start": "1995-08", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕人类增强与超人类主义报告或讨论可复核的学术证据。", "summary": "该节点将人类增强与超人类主义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1883" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 358 轮补录：人类增强与超人类主义；待本地复核。；日期补齐：Crossref 1995-08 (published-print, month, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-501", "title": "《Performance enhancement: Superhuman athletes》论文发表", "date_start": "2012-07-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕人类增强与超人类主义报告或讨论可复核的学术证据。", "summary": "该节点将人类增强与超人类主义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1884" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 358 轮补录：人类增强与超人类主义；待本地复核。；日期补齐：Crossref 2012-07-18 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-502", "title": "《Electronics: Silicon enhancement》论文发表", "date_start": "2008-08-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕人类增强与超人类主义报告或讨论可复核的学术证据。", "summary": "该节点将人类增强与超人类主义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1885" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 358 轮补录：人类增强与超人类主义；待本地复核。；日期补齐：Crossref 2008-08-27 (published-online, day, v3)", "created_at": "2026-08-07T07:37:37Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-077", "title": "《Ethical issues with brain-computer interfaces》论文发表", "date_start": "2014-07-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕神经权利与脑数据治理报告或讨论可复核的学术证据。", "summary": "该节点将神经权利与脑数据治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1886" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 359 轮补录：神经权利与脑数据治理；待本地复核。；日期补齐：Crossref 2014-07-30 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-078", "title": "《Towards new human rights in the age of neuroscience and neurotechnology》论文发表", "date_start": "2017-04-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕神经权利与脑数据治理报告或讨论可复核的学术证据。", "summary": "该节点将神经权利与脑数据治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1887" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 359 轮补录：神经权利与脑数据治理；待本地复核。；日期补齐：Crossref 2017-04-26 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-079", "title": "《Four ethical priorities for neurotechnologies and AI》论文发表", "date_start": "2017-11-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕神经权利与脑数据治理报告或讨论可复核的学术证据。", "summary": "该节点将神经权利与脑数据治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1888" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 359 轮补录：神经权利与脑数据治理；待本地复核。；日期补齐：Crossref 2017-11-09 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-080", "title": "《Declaration on the ethics of brain–computer interfaces and augment intelligence》论文发表", "date_start": "2021-01-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕神经权利与脑数据治理报告或讨论可复核的学术证据。", "summary": "该节点将神经权利与脑数据治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1889" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 359 轮补录：神经权利与脑数据治理；待本地复核。；日期补齐：Crossref 2021-01-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-081", "title": "《Big Brain Data: On the Responsible Use of Brain Data from Clinical and Consumer-Directed Neurotechnological Devices》论文发表", "date_start": "2018-05-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕神经权利与脑数据治理报告或讨论可复核的学术证据。", "summary": "该节点将神经权利与脑数据治理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1890" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 359 轮补录：神经权利与脑数据治理；待本地复核。；日期补齐：Crossref 2018-05-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-503", "title": "《Concrete Problems in AI Safety》论文发表", "date_start": "2016", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕人工智能对齐与安全报告或讨论可复核的学术证据。", "summary": "该节点将人工智能对齐与安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1891" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 360 轮补录：人工智能对齐与安全；待本地复核。", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-07T07:37:38Z" }, { "event_id": "HIT-THT-504", "title": "《The Alignment Problem from a Deep Learning Perspective》论文发表", "date_start": "2016", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕人工智能对齐与安全报告或讨论可复核的学术证据。", "summary": "该节点将人工智能对齐与安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1892" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 360 轮补录：人工智能对齐与安全；待本地复核。", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-07T07:37:38Z" }, { "event_id": "HIT-THT-505", "title": "《Safely Interruptible Agents》论文发表", "date_start": "2016", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕人工智能对齐与安全报告或讨论可复核的学术证据。", "summary": "该节点将人工智能对齐与安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1893" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 360 轮补录：人工智能对齐与安全；待本地复核。", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-07T07:37:38Z" }, { "event_id": "HIT-THT-506", "title": "《The Off-Switch Game》论文发表", "date_start": "2016", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕人工智能对齐与安全报告或讨论可复核的学术证据。", "summary": "该节点将人工智能对齐与安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1894" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 360 轮补录：人工智能对齐与安全；待本地复核。", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-07T07:37:38Z" }, { "event_id": "HIT-THT-507", "title": "《Scalable Agent Alignment via Reward Modeling: A Research Direction》论文发表", "date_start": "2018", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕人工智能对齐与安全报告或讨论可复核的学术证据。", "summary": "该节点将人工智能对齐与安全的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1895" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会基础设施、生态支持与个体韧性", "notes": "第 360 轮补录：人工智能对齐与安全；待本地复核。", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-07T07:37:38Z" }, { "event_id": "HIT-THT-508", "title": "《Countering Superintelligence Misinformation》论文发表", "date_start": "2018-09-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕超级智能与奇点报告或讨论可复核的学术证据。", "summary": "该节点将超级智能与奇点的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1896" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 361 轮补录：超级智能与奇点；待本地复核。；日期补齐：Crossref 2018-09-30 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-509", "title": "《Superintelligence Skepticism as a Political Tool》论文发表", "date_start": "2018-08-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕超级智能与奇点报告或讨论可复核的学术证据。", "summary": "该节点将超级智能与奇点的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1897" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 361 轮补录：超级智能与奇点；待本地复核。；日期补齐：Crossref 2018-08-22 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-510", "title": "《The singularity graveyard》论文发表", "date_start": "2022-01-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕超级智能与奇点报告或讨论可复核的学术证据。", "summary": "该节点将超级智能与奇点的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1898" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 361 轮补录：超级智能与奇点；待本地复核。；日期补齐：Crossref 2022-01-26 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-511", "title": "《A press release from just before the singularity》论文发表", "date_start": "2025-09-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕超级智能与奇点报告或讨论可复核的学术证据。", "summary": "该节点将超级智能与奇点的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1899" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 361 轮补录：超级智能与奇点；待本地复核。；日期补齐：Crossref 2025-09-24 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-512", "title": "《Mr Singularity》论文发表", "date_start": "2017-03-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕超级智能与奇点报告或讨论可复核的学术证据。", "summary": "该节点将超级智能与奇点的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1900" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 361 轮补录：超级智能与奇点；待本地复核。；日期补齐：Crossref 2017-03-23 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-082", "title": "《Risks and benefits of dual-use research》论文发表", "date_start": "2005-06-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕技术风险与双刃效应报告或讨论可复核的学术证据。", "summary": "该节点将技术风险与双刃效应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1901" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 362 轮补录：技术风险与双刃效应；待本地复核。；日期补齐：Crossref 2005-06-15 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-083", "title": "《Australia dials back effort to control ‘dual use’ research》论文发表", "date_start": "2019-02-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕技术风险与双刃效应报告或讨论可复核的学术证据。", "summary": "该节点将技术风险与双刃效应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1902" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 362 轮补录：技术风险与双刃效应；待本地复核。；日期补齐：Crossref 2019-02-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-084", "title": "《Terror watchdog set up for ‘dual use’ biology》论文发表", "date_start": "2004-03-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕技术风险与双刃效应报告或讨论可复核的学术证据。", "summary": "该节点将技术风险与双刃效应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1903" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 362 轮补录：技术风险与双刃效应；待本地复核。；日期补齐：Crossref 2004-03-11 (published-print, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-085", "title": "《Genetic risk of smoking and alcohol use examined》论文发表", "date_start": "2022-12-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕技术风险与双刃效应报告或讨论可复核的学术证据。", "summary": "该节点将技术风险与双刃效应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1904" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 362 轮补录：技术风险与双刃效应；待本地复核。；日期补齐：Crossref 2022-12-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-086", "title": "《Dual-use research needs international oversight》论文发表", "date_start": "2022-09-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕技术风险与双刃效应报告或讨论可复核的学术证据。", "summary": "该节点将技术风险与双刃效应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1905" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 362 轮补录：技术风险与双刃效应；待本地复核。；日期补齐：Crossref 2022-09-27 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-513", "title": "《A field guide to existential risk The Precipice: Existential Risk and the Future of Humanity Toby Ord Hachette, 2020. 480 pp.》论文发表", "date_start": "2020-05-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕文明转型与长期未来报告或讨论可复核的学术证据。", "summary": "该节点将文明转型与长期未来的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1906" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 363 轮补录：文明转型与长期未来；待本地复核。；日期补齐：Crossref 2020-05-08 (published-print, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-514", "title": "《Exponential Technology and The Singularity》论文发表", "date_start": "2014-11-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕文明转型与长期未来报告或讨论可复核的学术证据。", "summary": "该节点将文明转型与长期未来的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1907" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 363 轮补录：文明转型与长期未来；待本地复核。；日期补齐：Crossref 2014-11-18 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-515", "title": "《What We Owe the Future: A Million Year View》论文发表", "date_start": "2023-03-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕文明转型与长期未来报告或讨论可复核的学术证据。", "summary": "该节点将文明转型与长期未来的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1908" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 363 轮补录：文明转型与长期未来；待本地复核。；日期补齐：Crossref 2023-03-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-516", "title": "《What we owe (to) the present: Normative and practical challenges for strong longtermism》论文发表", "date_start": "2024-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕文明转型与长期未来报告或讨论可复核的学术证据。", "summary": "该节点将文明转型与长期未来的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1909" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 363 轮补录：文明转型与长期未来；待本地复核。；日期补齐：Crossref 2024-12 (published-print, month, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-517", "title": "《The Precipice. Existential Risk and the Future of Humanity, de T. Ord》论文发表", "date_start": "2021-08-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕文明转型与长期未来报告或讨论可复核的学术证据。", "summary": "该节点将文明转型与长期未来的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1910" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 363 轮补录：文明转型与长期未来；待本地复核。；日期补齐：Crossref 2021-08-23 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-518", "title": "《‘Early dark energy’ fails to solve mystery of cosmic expansion》论文发表", "date_start": "2023-11-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕宇宙智能与扩张报告或讨论可复核的学术证据。", "summary": "该节点将宇宙智能与扩张的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1911" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 364 轮补录：宇宙智能与扩张；待本地复核。；日期补齐：Crossref 2023-11-24 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-519", "title": "《New results intensify debate over cosmic expansion rate》论文发表", "date_start": "2024-08-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕宇宙智能与扩张报告或讨论可复核的学术证据。", "summary": "该节点将宇宙智能与扩张的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1912" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 364 轮补录：宇宙智能与扩张；待本地复核。；日期补齐：Crossref 2024-08-16 (published-print, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-520", "title": "《Ideal Mergers for Measuring Cosmic Expansion》论文发表", "date_start": "2018-07-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕宇宙智能与扩张报告或讨论可复核的学术证据。", "summary": "该节点将宇宙智能与扩张的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1913" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 364 轮补录：宇宙智能与扩张；待本地复核。；日期补齐：Crossref 2018-07-12 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-521", "title": "《Measuring Cosmic Expansion with a Lensed Supernova》论文发表", "date_start": "2023-05-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕宇宙智能与扩张报告或讨论可复核的学术证据。", "summary": "该节点将宇宙智能与扩张的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1914" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 364 轮补录：宇宙智能与扩张；待本地复核。；日期补齐：Crossref 2023-05-18 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-522", "title": "《Cosmic Expansion, Poco Adagio》论文发表", "date_start": "1999-01-15", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕宇宙智能与扩张报告或讨论可复核的学术证据。", "summary": "该节点将宇宙智能与扩张的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1915" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 364 轮补录：宇宙智能与扩张；待本地复核。；日期补齐：Crossref 1999-01-15 (published-print, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-523", "title": "《Tackling Climate Change with Machine Learning》论文发表", "date_start": "2022-02-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕算力基础设施与智能报告或讨论可复核的学术证据。", "summary": "该节点将算力基础设施与智能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1916" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 365 轮补录：算力基础设施与智能；待本地复核。；日期补齐：Crossref 2022-02-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-524", "title": "《Language Models are Few-Shot Learners》论文发表", "date_start": "2020", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕算力基础设施与智能报告或讨论可复核的学术证据。", "summary": "该节点将算力基础设施与智能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1917" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 365 轮补录：算力基础设施与智能；待本地复核。", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-07T07:37:38Z" }, { "event_id": "HIT-THT-525", "title": "《Training Compute-Optimal Large Language Models》论文发表", "date_start": "2022", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕算力基础设施与智能报告或讨论可复核的学术证据。", "summary": "该节点将算力基础设施与智能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1918" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 365 轮补录：算力基础设施与智能；待本地复核。", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-07T07:37:38Z" }, { "event_id": "HIT-THT-526", "title": "《Carbon Emissions and Large Neural Network Training》论文发表", "date_start": "2021", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕算力基础设施与智能报告或讨论可复核的学术证据。", "summary": "该节点将算力基础设施与智能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1919" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 365 轮补录：算力基础设施与智能；待本地复核。", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-07T07:37:38Z" }, { "event_id": "HIT-THT-527", "title": "《The Computational Limits of Deep Learning》论文发表", "date_start": "2020", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕算力基础设施与智能报告或讨论可复核的学术证据。", "summary": "该节点将算力基础设施与智能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1920" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 365 轮补录：算力基础设施与智能；待本地复核。", "created_at": "2026-08-07T07:37:38Z", "updated_at": "2026-08-07T07:37:38Z" }, { "event_id": "HIT-TEC-1035", "title": "《High-performance medicine: the convergence of human and artificial intelligence》论文发表", "date_start": "2019-01-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数据科学与健康报告或讨论可复核的学术证据。", "summary": "该节点将数据科学与健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1921" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 366 轮补录：数据科学与健康；待本地复核。；日期补齐：Crossref 2019-01-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1036", "title": "《Big Data and Machine Learning in Health Care》论文发表", "date_start": "2018-04-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数据科学与健康报告或讨论可复核的学术证据。", "summary": "该节点将数据科学与健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1922" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 366 轮补录：数据科学与健康；待本地复核。；日期补齐：Crossref 2018-04-03 (published-print, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1037", "title": "《Predicting the Future — Big Data, Machine Learning, and Clinical Medicine》论文发表", "date_start": "2016-09-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数据科学与健康报告或讨论可复核的学术证据。", "summary": "该节点将数据科学与健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1923" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 366 轮补录：数据科学与健康；待本地复核。；日期补齐：Crossref 2016-09-29 (published-print, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1038", "title": "《Scalable and accurate deep learning with electronic health records》论文发表", "date_start": "2018-05-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数据科学与健康报告或讨论可复核的学术证据。", "summary": "该节点将数据科学与健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1924" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 366 轮补录：数据科学与健康；待本地复核。；日期补齐：Crossref 2018-05-08 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1039", "title": "《Health intelligence: how artificial intelligence transforms population and personalized health》论文发表", "date_start": "2018-10-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数据科学与健康报告或讨论可复核的学术证据。", "summary": "该节点将数据科学与健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1925" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 366 轮补录：数据科学与健康；待本地复核。；日期补齐：Crossref 2018-10-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1040", "title": "《Building a modular and multi-cellular virtual twin of the synovial joint in Rheumatoid Arthritis》论文发表", "date_start": "2024-12-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与预测健康报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与预测健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1926" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 367 轮补录：数字孪生与预测健康；待本地复核。；日期补齐：Crossref 2024-12-24 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1041", "title": "《Digital twins in medicine》论文发表", "date_start": "2024-03-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与预测健康报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与预测健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1927" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 367 轮补录：数字孪生与预测健康；待本地复核。；日期补齐：Crossref 2024-03-26 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1042", "title": "《A Systematic Review of Digital Twin Technology for Home Care》论文发表", "date_start": "2024-11-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与预测健康报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与预测健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1928" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 367 轮补录：数字孪生与预测健康；待本地复核。；日期补齐：Crossref 2024-11-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1043", "title": "《A health digital twin framework for discrete event simulation based optimised critical care workflows》论文发表", "date_start": "2025-06-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与预测健康报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与预测健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1929" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 367 轮补录：数字孪生与预测健康；待本地复核。；日期补齐：Crossref 2025-06-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1044", "title": "《Realizing the Potential of Computer-Assisted Surgery by Embedding Digital Twin Technology》论文发表", "date_start": "2022-11-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cognitive_extension", "event_type": "technology", "claim": "该文献围绕数字孪生与预测健康报告或讨论可复核的学术证据。", "summary": "该节点将数字孪生与预测健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1930" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 367 轮补录：数字孪生与预测健康；待本地复核。；日期补齐：Crossref 2022-11-08 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1045", "title": "《Reversal of epigenetic aging and immunosenescent trends in humans》论文发表", "date_start": "2019-09-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物年龄干预报告或讨论可复核的学术证据。", "summary": "该节点将生物年龄干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1931" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 368 轮补录：生物年龄干预；待本地复核。；日期补齐：Crossref 2019-09-08 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1046", "title": "《Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)—intervention study protocol》论文发表", "date_start": "2023-05-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物年龄干预报告或讨论可复核的学术证据。", "summary": "该节点将生物年龄干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1932" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 368 轮补录：生物年龄干预；待本地复核。；日期补齐：Crossref 2023-05-23 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1047", "title": "《Measuring biological age using metabolomics》论文发表", "date_start": "2020-11-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物年龄干预报告或讨论可复核的学术证据。", "summary": "该节点将生物年龄干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1933" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 368 轮补录：生物年龄干预；待本地复核。；日期补齐：Crossref 2020-11-29 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1048", "title": "《Transient and late-life rapamycin for healthspan extension》论文发表", "date_start": "2020-03-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物年龄干预报告或讨论可复核的学术证据。", "summary": "该节点将生物年龄干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1934" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 368 轮补录：生物年龄干预；待本地复核。；日期补齐：Crossref 2020-03-12 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1049", "title": "《Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial—Correction》论文发表", "date_start": "2006-06-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物年龄干预报告或讨论可复核的学术证据。", "summary": "该节点将生物年龄干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1935" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 368 轮补录：生物年龄干预；待本地复核。；日期补齐：Crossref 2006-06-07 (published-print, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1050", "title": "《Rapamycin fed late in life extends lifespan in genetically heterogeneous mice》论文发表", "date_start": "2009-07-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕药物再利用与长寿报告或讨论可复核的学术证据。", "summary": "该节点将药物再利用与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1936" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 369 轮补录：药物再利用与长寿；待本地复核。；日期补齐：Crossref 2009-07-08 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1051", "title": "《Drug repurposing: progress, challenges and recommendations》论文发表", "date_start": "2018-10-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕药物再利用与长寿报告或讨论可复核的学术证据。", "summary": "该节点将药物再利用与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1937" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 369 轮补录：药物再利用与长寿；待本地复核。；日期补齐：Crossref 2018-10-12 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1052", "title": "《Rapamycin and Ageing: When, for How Long, and How Much?》论文发表", "date_start": "2014-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕药物再利用与长寿报告或讨论可复核的学术证据。", "summary": "该节点将药物再利用与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1938" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 369 轮补录：药物再利用与长寿；待本地复核。；日期补齐：Crossref 2014-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1053", "title": "《Rapamycin As an Antiaging Therapeutic?: Targeting Mammalian Target of Rapamycin to Treat Hutchinson–Gilford Progeria and Neurodegenerative Diseases》论文发表", "date_start": "2011-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕药物再利用与长寿报告或讨论可复核的学术证据。", "summary": "该节点将药物再利用与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1939" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 369 轮补录：药物再利用与长寿；待本地复核。；日期补齐：Crossref 2011-08 (published-online, month, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1054", "title": "《A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice》论文发表", "date_start": "2012-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕药物再利用与长寿报告或讨论可复核的学术证据。", "summary": "该节点将药物再利用与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1940" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 369 轮补录：药物再利用与长寿；待本地复核。；日期补齐：Crossref 2012-01 (published-online, month, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1055", "title": "《Nutrition, longevity and disease: From molecular mechanisms to interventions》论文发表", "date_start": "2022-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕营养干预与禁食报告或讨论可复核的学术证据。", "summary": "该节点将营养干预与禁食的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1941" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 370 轮补录：营养干预与禁食；待本地复核。；日期补齐：Crossref 2022-04 (published-print, month, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1056", "title": "《Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans》论文发表", "date_start": "2008-12-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕营养干预与禁食报告或讨论可复核的学术证据。", "summary": "该节点将营养干预与禁食的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1942" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 370 轮补录：营养干预与禁食；待本地复核。；日期补齐：Crossref 2008-12-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1057", "title": "《Investigating fasting for metabolic health and longevity》论文发表", "date_start": "2026-04-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕营养干预与禁食报告或讨论可复核的学术证据。", "summary": "该节点将营养干预与禁食的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1943" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 370 轮补录：营养干预与禁食；待本地复核。；日期补齐：Crossref 2026-04-27 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1058", "title": "《Feasting and fasting》论文发表", "date_start": "2008-07-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕营养干预与禁食报告或讨论可复核的学术证据。", "summary": "该节点将营养干预与禁食的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1944" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 370 轮补录：营养干预与禁食；待本地复核。；日期补齐：Crossref 2008-07-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1059", "title": "《Nutrigenomics and Personalized Nutrition in the Context of Aging》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕营养干预与禁食报告或讨论可复核的学术证据。", "summary": "该节点将营养干预与禁食的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1945" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 370 轮补录：营养干预与禁食；待本地复核。；日期补齐：Crossref 2024 (published-online, year, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1060", "title": "《Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy》论文发表", "date_start": "2012-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕运动与身体韧性报告或讨论可复核的学术证据。", "summary": "该节点将运动与身体韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1946" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 371 轮补录：运动与身体韧性；待本地复核。；日期补齐：Crossref 2012-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1061", "title": "《Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women》论文发表", "date_start": "2016-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕运动与身体韧性报告或讨论可复核的学术证据。", "summary": "该节点将运动与身体韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1947" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 371 轮补录：运动与身体韧性；待本地复核。；日期补齐：Crossref 2016-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1062", "title": "《Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults》论文发表", "date_start": "2014-06-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕运动与身体韧性报告或讨论可复核的学术证据。", "summary": "该节点将运动与身体韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1948" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 371 轮补录：运动与身体韧性；待本地复核。；日期补齐：Crossref 2014-06-18 (published-print, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1063", "title": "《Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults》论文发表", "date_start": "2011-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕运动与身体韧性报告或讨论可复核的学术证据。", "summary": "该节点将运动与身体韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1949" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 371 轮补录：运动与身体韧性；待本地复核。；日期补齐：Crossref 2011-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1064", "title": "《Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors》论文发表", "date_start": "2018-08-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕运动与身体韧性报告或讨论可复核的学术证据。", "summary": "该节点将运动与身体韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1950" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 371 轮补录：运动与身体韧性；待本地复核。；日期补齐：Crossref 2018-08-16 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1065", "title": "《Aging, Subjective Sleep Quality, and Health Status: The Global Picture》论文发表", "date_start": "2012-08-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与恢复报告或讨论可复核的学术证据。", "summary": "该节点将睡眠与恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1951" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 372 轮补录：睡眠与恢复；待本地复核。；日期补齐：Crossref 2012-08-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1066", "title": "《1294 What Factors Influence Sleep Health During Recovery After Stroke?》论文发表", "date_start": "2025-05-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与恢复报告或讨论可复核的学术证据。", "summary": "该节点将睡眠与恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1952" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 372 轮补录：睡眠与恢复；待本地复核。；日期补齐：Crossref 2025-05-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1067", "title": "《1039 Diffusion Imaging Markers of Glymphatic Function in Veterans with Sleep Dysfunction and Mild Traumatic Brain Injury》论文发表", "date_start": "2024-04-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与恢复报告或讨论可复核的学术证据。", "summary": "该节点将睡眠与恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1953" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 372 轮补录：睡眠与恢复；待本地复核。；日期补齐：Crossref 2024-04-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1068", "title": "《0453 Hypoxia Affects Glymphatic Efficiency: Assessing Glymphatic Disruption in Obstructive Sleep Apnea Using Near-Infrared Spectroscopy》论文发表", "date_start": "2025-05-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与恢复报告或讨论可复核的学术证据。", "summary": "该节点将睡眠与恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1954" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 372 轮补录：睡眠与恢复；待本地复核。；日期补齐：Crossref 2025-05-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1069", "title": "《Can we monitor and enhance glymphatic clearance during sleep?》论文发表", "date_start": "2026-05-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕睡眠与恢复报告或讨论可复核的学术证据。", "summary": "该节点将睡眠与恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1955" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 372 轮补录：睡眠与恢复；待本地复核。；日期补齐：Crossref 2026-05-28 (published-online, day, v3)", "created_at": "2026-08-07T07:37:39Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1070", "title": "《Interacting mediators of allostasis and allostatic load: towards an understanding of resilience in aging》论文发表", "date_start": "2003-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕压力与应激韧性报告或讨论可复核的学术证据。", "summary": "该节点将压力与应激韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1956" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 373 轮补录：压力与应激韧性；待本地复核。；日期补齐：Crossref 2003-10 (published-print, month, v3)", "created_at": "2026-08-07T07:37:40Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1071", "title": "《Root of resilience under stress》论文发表", "date_start": "2011-02-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕压力与应激韧性报告或讨论可复核的学术证据。", "summary": "该节点将压力与应激韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1957" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 373 轮补录：压力与应激韧性；待本地复核。；日期补齐：Crossref 2011-02-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1072", "title": "《Stress: The roots of resilience》论文发表", "date_start": "2012-10-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕压力与应激韧性报告或讨论可复核的学术证据。", "summary": "该节点将压力与应激韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1958" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 373 轮补录：压力与应激韧性；待本地复核。；日期补齐：Crossref 2012-10-10 (published-online, day, v3)", "created_at": "2026-08-07T07:37:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1073", "title": "《Brain’s reward region helps to supply resilience in the face of stress》论文发表", "date_start": "2019-12-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕压力与应激韧性报告或讨论可复核的学术证据。", "summary": "该节点将压力与应激韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1959" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 373 轮补录：压力与应激韧性；待本地复核。；日期补齐：Crossref 2019-12-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1074", "title": "《Stress-test the resilience of critical infrastructure》论文发表", "date_start": "2022-03-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕压力与应激韧性报告或讨论可复核的学术证据。", "summary": "该节点将压力与应激韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1960" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 373 轮补录：压力与应激韧性；待本地复核。；日期补齐：Crossref 2022-03-22 (published-online, day, v3)", "created_at": "2026-08-07T07:37:40Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1075", "title": "《Whitefly hijacks a plant detoxification gene that neutralizes plant toxins》论文发表", "date_start": "2021-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕环境毒素与去毒报告或讨论可复核的学术证据。", "summary": "该节点将环境毒素与去毒的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1961" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 374 轮补录：环境毒素与去毒；待本地复核。；日期补齐：Crossref 2021-06 (published-print, month, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1076", "title": "《Whitefly hijacks a plant detoxification gene that neutralizes plant toxins》论文发表", "date_start": "2021-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕环境毒素与去毒报告或讨论可复核的学术证据。", "summary": "该节点将环境毒素与去毒的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1962" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 374 轮补录：环境毒素与去毒；待本地复核。；日期补齐：Crossref 2021-04 (published-print, month, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1077", "title": "《The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins》论文发表", "date_start": "2008-03-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕环境毒素与去毒报告或讨论可复核的学术证据。", "summary": "该节点将环境毒素与去毒的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1963" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 374 轮补录：环境毒素与去毒；待本地复核。；日期补齐：Crossref 2008-03-23 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1078", "title": "《World’s first full-body PET scanner could aid drug development, monitor environmental toxins》论文发表", "date_start": "2017-03-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕环境毒素与去毒报告或讨论可复核的学术证据。", "summary": "该节点将环境毒素与去毒的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1964" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 374 轮补录：环境毒素与去毒；待本地复核。；日期补齐：Crossref 2017-03-17 (published-print, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1079", "title": "《A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability》论文发表", "date_start": "2017-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕环境毒素与去毒报告或讨论可复核的学术证据。", "summary": "该节点将环境毒素与去毒的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1965" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 374 轮补录：环境毒素与去毒；待本地复核。；日期补齐：Crossref 2017-06 (published-print, month, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1080", "title": "《Efficacy of zinc carnosine in the treatment of colorectal cancer and its potential in combination with immunotherapy in vivo》论文发表", "date_start": "2022-11-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕免疫治疗与肿瘤报告或讨论可复核的学术证据。", "summary": "该节点将免疫治疗与肿瘤的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1966" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 375 轮补录：免疫治疗与肿瘤；待本地复核。；日期补齐：Crossref 2022-11-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1081", "title": "《Cancer Immunotherapy: A Treatment for the Masses》论文发表", "date_start": "2004-07-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕免疫治疗与肿瘤报告或讨论可复核的学术证据。", "summary": "该节点将免疫治疗与肿瘤的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1967" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 375 轮补录：免疫治疗与肿瘤；待本地复核。；日期补齐：Crossref 2004-07-09 (published-print, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1082", "title": "《Cancer immunotherapy: weak beats strong》论文发表", "date_start": "2016-11-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕免疫治疗与肿瘤报告或讨论可复核的学术证据。", "summary": "该节点将免疫治疗与肿瘤的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1968" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 375 轮补录：免疫治疗与肿瘤；待本地复核。；日期补齐：Crossref 2016-11-30 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1083", "title": "《Cancer Immunotherapy Booster》论文发表", "date_start": "2016-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕免疫治疗与肿瘤报告或讨论可复核的学术证据。", "summary": "该节点将免疫治疗与肿瘤的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1969" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 375 轮补录：免疫治疗与肿瘤；待本地复核。；日期补齐：Crossref 2016-04 (published-print, month, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1084", "title": "《Challenges in targeting the tryptophan metabolism in cancer immunotherapy》论文发表", "date_start": "2021-08-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕免疫治疗与肿瘤报告或讨论可复核的学术证据。", "summary": "该节点将免疫治疗与肿瘤的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1970" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 375 轮补录：免疫治疗与肿瘤；待本地复核。；日期补齐：Crossref 2021-08-26 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1085", "title": "《Early detection versus prevention in colorectal cancer screening: Methods estimates and public health implications》论文发表", "date_start": "2017-10-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕癌症预防与早筛报告或讨论可复核的学术证据。", "summary": "该节点将癌症预防与早筛的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1971" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 376 轮补录：癌症预防与早筛；待本地复核。；日期补齐：Crossref 2017-10-04 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1086", "title": "《Huge lung-cancer screening campaign boosts early diagnosis》论文发表", "date_start": "2026-03-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕癌症预防与早筛报告或讨论可复核的学术证据。", "summary": "该节点将癌症预防与早筛的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1972" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 376 轮补录：癌症预防与早筛；待本地复核。；日期补齐：Crossref 2026-03-27 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1087", "title": "《Early-onset cancer fuels calls for wider screening — but at what cost?》论文发表", "date_start": "2026-04-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕癌症预防与早筛报告或讨论可复核的学术证据。", "summary": "该节点将癌症预防与早筛的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1973" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 376 轮补录：癌症预防与早筛；待本地复核。；日期补齐：Crossref 2026-04-15 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1088", "title": "《Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers》论文发表", "date_start": "2026-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕癌症预防与早筛报告或讨论可复核的学术证据。", "summary": "该节点将癌症预防与早筛的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1974" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 376 轮补录：癌症预防与早筛；待本地复核。；日期补齐：Crossref 2026-04 (published-print, month, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1089", "title": "《Metformin for aging and cancer prevention》论文发表", "date_start": "2010-11-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕癌症预防与早筛报告或讨论可复核的学术证据。", "summary": "该节点将癌症预防与早筛的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1975" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 376 轮补录：癌症预防与早筛；待本地复核。；日期补齐：Crossref 2010-11-11 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1090", "title": "《The future of precision cancer therapy might be to try everything》论文发表", "date_start": "2024-02-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕癌症治疗与治愈报告或讨论可复核的学术证据。", "summary": "该节点将癌症治疗与治愈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1976" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 377 轮补录：癌症治疗与治愈；待本地复核。；日期补齐：Crossref 2024-02-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1091", "title": "《Using Genes to Cure Cancer》论文发表", "date_start": "1999-09", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕癌症治疗与治愈报告或讨论可复核的学术证据。", "summary": "该节点将癌症治疗与治愈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1977" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 377 轮补录：癌症治疗与治愈；待本地复核。；日期补齐：Crossref 1999-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1092", "title": "《Rationalizing rules for immunotherapy combination trials: About time for precision immunotherapy》论文发表", "date_start": "2022-10-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕癌症治疗与治愈报告或讨论可复核的学术证据。", "summary": "该节点将癌症治疗与治愈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1978" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 377 轮补录：癌症治疗与治愈；待本地复核。；日期补齐：Crossref 2022-10-30 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1093", "title": "《Early results support base‐edited anti‐CD7 CAR T‐cell therapy in T‐cell ALL》论文发表", "date_start": "2026-05-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕癌症治疗与治愈报告或讨论可复核的学术证据。", "summary": "该节点将癌症治疗与治愈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1979" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 377 轮补录：癌症治疗与治愈；待本地复核。；日期补齐：Crossref 2026-05-16 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1094", "title": "《High response rates with novel CAR T‐cell therapy for adults with advanced B‐cell ALL》论文发表", "date_start": "2025-04-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕癌症治疗与治愈报告或讨论可复核的学术证据。", "summary": "该节点将癌症治疗与治愈的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1980" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 377 轮补录：癌症治疗与治愈；待本地复核。；日期补齐：Crossref 2025-04-15 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1095", "title": "《Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis》论文发表", "date_start": "2022-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕感染与病原体控制报告或讨论可复核的学术证据。", "summary": "该节点将感染与病原体控制的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1981" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 378 轮补录：感染与病原体控制；待本地复核。；日期补齐：Crossref 2022-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1096", "title": "《COVID-19: towards controlling of a pandemic》论文发表", "date_start": "2020-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕感染与病原体控制报告或讨论可复核的学术证据。", "summary": "该节点将感染与病原体控制的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1982" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 378 轮补录：感染与病原体控制；待本地复核。；日期补齐：Crossref 2020-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1097", "title": "《The Lancet Commission on lessons for the future from the COVID-19 pandemic》论文发表", "date_start": "2022-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕感染与病原体控制报告或讨论可复核的学术证据。", "summary": "该节点将感染与病原体控制的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1983" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 378 轮补录：感染与病原体控制；待本地复核。；日期补齐：Crossref 2022-10 (published-print, month, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1098", "title": "《Symposium: Public Health Preparedness》论文发表", "date_start": "2007-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕感染与病原体控制报告或讨论可复核的学术证据。", "summary": "该节点将感染与病原体控制的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1984" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 378 轮补录：感染与病原体控制；待本地复核。；日期补齐：Crossref 2007-04-01 (published-print, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1099", "title": "《Assessing Public Health Emergency Preparedness: Concepts, Tools, and Challenges》论文发表", "date_start": "2007-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕感染与病原体控制报告或讨论可复核的学术证据。", "summary": "该节点将感染与病原体控制的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1985" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 378 轮补录：感染与病原体控制；待本地复核。；日期补齐：Crossref 2007-04-01 (published-print, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1100", "title": "《Are non-antibiotic drugs contributing to antimicrobial resistance?》论文发表", "date_start": "2026-05-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕抗生素与抗微生物报告或讨论可复核的学术证据。", "summary": "该节点将抗生素与抗微生物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1986" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 379 轮补录：抗生素与抗微生物；待本地复核。；日期补齐：Crossref 2026-05-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1101", "title": "《Antibiotic resistance racing downriver》论文发表", "date_start": "2012-10-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕抗生素与抗微生物报告或讨论可复核的学术证据。", "summary": "该节点将抗生素与抗微生物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1987" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 379 轮补录：抗生素与抗微生物；待本地复核。；日期补齐：Crossref 2012-10-17 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1102", "title": "《Antibiotic resistance switched off》论文发表", "date_start": "2001-03-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕抗生素与抗微生物报告或讨论可复核的学术证据。", "summary": "该节点将抗生素与抗微生物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1988" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 379 轮补录：抗生素与抗微生物；待本地复核。；日期补齐：Crossref 2001-03-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1103", "title": "《Diagnostic developers target antibiotic resistance》论文发表", "date_start": "2015-10-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕抗生素与抗微生物报告或讨论可复核的学术证据。", "summary": "该节点将抗生素与抗微生物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1989" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 379 轮补录：抗生素与抗微生物；待本地复核。；日期补齐：Crossref 2015-10-09 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1104", "title": "《Antibiotic resistance marching across Europe》论文发表", "date_start": "2011-11-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕抗生素与抗微生物报告或讨论可复核的学术证据。", "summary": "该节点将抗生素与抗微生物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1990" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 379 轮补录：抗生素与抗微生物；待本地复核。；日期补齐：Crossref 2011-11-22 (published-online, day, v3)", "created_at": "2026-08-07T07:37:41Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1105", "title": "《A Comparative Study on Immune Protection Efficacy: An HSV-1 Trivalent Antigen Subunit Vaccine Formulated with a Cellular Immunity-Inducing Adjuvant Versus an mRNA Vaccine》论文发表", "date_start": "2025-09-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕疫苗与免疫保护报告或讨论可复核的学术证据。", "summary": "该节点将疫苗与免疫保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1991" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 380 轮补录：疫苗与免疫保护；待本地复核。；日期补齐：Crossref 2025-09-10 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1106", "title": "《Malaria vaccine booster prolongs protection》论文发表", "date_start": "2022-09-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕疫苗与免疫保护报告或讨论可复核的学术证据。", "summary": "该节点将疫苗与免疫保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1992" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 380 轮补录：疫苗与免疫保护；待本地复核。；日期补齐：Crossref 2022-09-09 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1107", "title": "《Fungal sugars boost vaccine protection》论文发表", "date_start": "2022-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕疫苗与免疫保护报告或讨论可复核的学术证据。", "summary": "该节点将疫苗与免疫保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1993" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 380 轮补录：疫苗与免疫保护；待本地复核。；日期补齐：Crossref 2022-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1108", "title": "《Combo COVID-19 and Flu mRNA Vaccine Falls Short of Total Flu Protection》论文发表", "date_start": "2024-10-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕疫苗与免疫保护报告或讨论可复核的学术证据。", "summary": "该节点将疫苗与免疫保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1994" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 380 轮补录：疫苗与免疫保护；待本地复核。；日期补齐：Crossref 2024-10-08 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1109", "title": "《Discerning dengue vaccine protection》论文发表", "date_start": "2016-09-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕疫苗与免疫保护报告或讨论可复核的学术证据。", "summary": "该节点将疫苗与免疫保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1995" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "智能爆炸、风险治理与文明转型", "notes": "第 380 轮补录：疫苗与免疫保护；待本地复核。；日期补齐：Crossref 2016-09-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1110", "title": "《Organoids-on-a-chip》论文发表", "date_start": "2019-06-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕器官芯片与药物评价报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片与药物评价的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1996" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 381 轮补录：器官芯片与药物评价；待本地复核。；日期补齐：Crossref 2019-06-07 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1111", "title": "《Human organs-on-chips for disease modelling, drug development and personalized medicine》论文发表", "date_start": "2022-03-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕器官芯片与药物评价报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片与药物评价的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1997" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 381 轮补录：器官芯片与药物评价；待本地复核。；日期补齐：Crossref 2022-03-25 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1112", "title": "《Organs-on-chips: into the next decade》论文发表", "date_start": "2020-09-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕器官芯片与药物评价报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片与药物评价的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1998" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 381 轮补录：器官芯片与药物评价；待本地复核。；日期补齐：Crossref 2020-09-10 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1113", "title": "《Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature》论文发表", "date_start": "2021", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕器官芯片与药物评价报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片与药物评价的最新证据纳入有效永生研究年表。", "sources": [ "SRC-1999" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 381 轮补录：器官芯片与药物评价；待本地复核。；日期补齐：Crossref 2021 (published-online, year, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1114", "title": "《Organs-on-chips at the frontiers of drug discovery》论文发表", "date_start": "2015-03-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕器官芯片与药物评价报告或讨论可复核的学术证据。", "summary": "该节点将器官芯片与药物评价的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2000" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 381 轮补录：器官芯片与药物评价；待本地复核。；日期补齐：Crossref 2015-03-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1115", "title": "《The Imperative for Innovative Enteric Nervous System–Intestinal Organoid Co-Culture Models: Transforming GI Disease Modeling and Treatment》论文发表", "date_start": "2024-05-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕类器官与疾病建模报告或讨论可复核的学术证据。", "summary": "该节点将类器官与疾病建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2001" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 382 轮补录：类器官与疾病建模；待本地复核。；日期补齐：Crossref 2024-05-10 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1116", "title": "《Advances in Cerebral Organoid Systems and their Application in Disease Modeling》论文发表", "date_start": "2019-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕类器官与疾病建模报告或讨论可复核的学术证据。", "summary": "该节点将类器官与疾病建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2002" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 382 轮补录：类器官与疾病建模；待本地复核。；日期补齐：Crossref 2019-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1117", "title": "《Human airway organoid engineering as a step toward lung regeneration and disease modeling》论文发表", "date_start": "2017-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕类器官与疾病建模报告或讨论可复核的学术证据。", "summary": "该节点将类器官与疾病建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2003" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 382 轮补录：类器官与疾病建模；待本地复核。；日期补齐：Crossref 2017-01 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1118", "title": "《Cancer modeling meets human organoid technology》论文发表", "date_start": "2019-06-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕类器官与疾病建模报告或讨论可复核的学术证据。", "summary": "该节点将类器官与疾病建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2004" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 382 轮补录：类器官与疾病建模；待本地复核。；日期补齐：Crossref 2019-06-07 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1119", "title": "《This organoid can menstruate — and shows how tissue can repair itself》论文发表", "date_start": "2026-05-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕类器官与疾病建模报告或讨论可复核的学术证据。", "summary": "该节点将类器官与疾病建模的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2005" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 382 轮补录：类器官与疾病建模；待本地复核。；日期补齐：Crossref 2026-05-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1120", "title": "《3D extrusion bioprinting》论文发表", "date_start": "2021-11-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕3D生物打印与器官制造报告或讨论可复核的学术证据。", "summary": "该节点将3D生物打印与器官制造的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2006" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 383 轮补录：3D生物打印与器官制造；待本地复核。；日期补齐：Crossref 2021-11-11 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1121", "title": "《A 3D bioprinting system to produce human-scale tissue constructs with structural integrity》论文发表", "date_start": "2016-02-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕3D生物打印与器官制造报告或讨论可复核的学术证据。", "summary": "该节点将3D生物打印与器官制造的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2007" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 383 轮补录：3D生物打印与器官制造；待本地复核。；日期补齐：Crossref 2016-02-15 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1122", "title": "《3D bioprinting of collagen to rebuild components of the human heart》论文发表", "date_start": "2019-08-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕3D生物打印与器官制造报告或讨论可复核的学术证据。", "summary": "该节点将3D生物打印与器官制造的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2008" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 383 轮补录：3D生物打印与器官制造；待本地复核。；日期补齐：Crossref 2019-08-02 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1123", "title": "《Bioprinting scale-up tissue and organ constructs for transplantation》论文发表", "date_start": "2015-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕3D生物打印与器官制造报告或讨论可复核的学术证据。", "summary": "该节点将3D生物打印与器官制造的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2009" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 383 轮补录：3D生物打印与器官制造；待本地复核。；日期补齐：Crossref 2015-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1124", "title": "《Advances in 3D bioprinting of tissues/organs for regenerative medicine and in-vitro models》论文发表", "date_start": "2022-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕3D生物打印与器官制造报告或讨论可复核的学术证据。", "summary": "该节点将3D生物打印与器官制造的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2010" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 383 轮补录：3D生物打印与器官制造；待本地复核。；日期补齐：Crossref 2022-08 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1125", "title": "《Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia》论文发表", "date_start": "2014-10-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕细胞治疗与再生医学报告或讨论可复核的学术证据。", "summary": "该节点将细胞治疗与再生医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2011" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 384 轮补录：细胞治疗与再生医学；待本地复核。；日期补齐：Crossref 2014-10-16 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1126", "title": "《CAR T cell immunotherapy for human cancer》论文发表", "date_start": "2018-03-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕细胞治疗与再生医学报告或讨论可复核的学术证据。", "summary": "该节点将细胞治疗与再生医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2012" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 384 轮补录：细胞治疗与再生医学；待本地复核。；日期补齐：Crossref 2018-03-23 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1127", "title": "《Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma》论文发表", "date_start": "2017-12-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕细胞治疗与再生医学报告或讨论可复核的学术证据。", "summary": "该节点将细胞治疗与再生医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2013" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 384 轮补录：细胞治疗与再生医学；待本地复核。；日期补齐：Crossref 2017-12-28 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1128", "title": "《The Principles of Engineering Immune Cells to Treat Cancer》论文发表", "date_start": "2017-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕细胞治疗与再生医学报告或讨论可复核的学术证据。", "summary": "该节点将细胞治疗与再生医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2014" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 384 轮补录：细胞治疗与再生医学；待本地复核。；日期补齐：Crossref 2017-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1129", "title": "《Adoptive cell transfer as personalized immunotherapy for human cancer》论文发表", "date_start": "2015-04-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕细胞治疗与再生医学报告或讨论可复核的学术证据。", "summary": "该节点将细胞治疗与再生医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2015" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 384 轮补录：细胞治疗与再生医学；待本地复核。；日期补齐：Crossref 2015-04-03 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1130", "title": "《CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis》论文发表", "date_start": "2021-08-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因治疗与体内编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因治疗与体内编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2016" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 385 轮补录：基因治疗与体内编辑；待本地复核。；日期补齐：Crossref 2021-08-05 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1131", "title": "《CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia》论文发表", "date_start": "2021-01-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因治疗与体内编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因治疗与体内编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2017" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 385 轮补录：基因治疗与体内编辑；待本地复核。；日期补齐：Crossref 2021-01-21 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1132", "title": "《Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy》论文发表", "date_start": "2017-11-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因治疗与体内编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因治疗与体内编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2018" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 385 轮补录：基因治疗与体内编辑；待本地复核。；日期补齐：Crossref 2017-11-02 (published-print, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1133", "title": "《Therapeutic in vivo delivery of gene editing agents》论文发表", "date_start": "2022-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因治疗与体内编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因治疗与体内编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2019" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 385 轮补录：基因治疗与体内编辑；待本地复核。；日期补齐：Crossref 2022-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1134", "title": "《Search-and-replace genome editing without double-strand breaks or donor DNA》论文发表", "date_start": "2019-10-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕基因治疗与体内编辑报告或讨论可复核的学术证据。", "summary": "该节点将基因治疗与体内编辑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2020" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 385 轮补录：基因治疗与体内编辑；待本地复核。；日期补齐：Crossref 2019-10-21 (published-online, day, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1135", "title": "《De novo protein design—From new structures to programmable functions》论文发表", "date_start": "2024-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕蛋白质工程与设计报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质工程与设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2021" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 386 轮补录：蛋白质工程与设计；待本地复核。；日期补齐：Crossref 2024-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1136", "title": "《Structure and Protein Design of a Human Platelet Function Inhibitor》论文发表", "date_start": "2004-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕蛋白质工程与设计报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质工程与设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2022" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 386 轮补录：蛋白质工程与设计；待本地复核。；日期补齐：Crossref 2004-04 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1137", "title": "《Structure and Protein Design of a Human Platelet Function Inhibitor》论文发表", "date_start": "2004-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕蛋白质工程与设计报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质工程与设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2023" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 386 轮补录：蛋白质工程与设计；待本地复核。；日期补齐：Crossref 2004-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1138", "title": "《Design and engineering of an O2 transport protein》论文发表", "date_start": "2009-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕蛋白质工程与设计报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质工程与设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2024" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 386 轮补录：蛋白质工程与设计；待本地复核。；日期补齐：Crossref 2009-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1139", "title": "《Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution》论文发表", "date_start": "2012-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕蛋白质工程与设计报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质工程与设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2025" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 386 轮补录：蛋白质工程与设计；待本地复核。；日期补齐：Crossref 2012-04 (published-print, month, v3)", "created_at": "2026-08-07T07:37:42Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1140", "title": "《Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation》论文发表", "date_start": "2009-07-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕RNA治疗与mRNA医学报告或讨论可复核的学术证据。", "summary": "该节点将RNA治疗与mRNA医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2026" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 387 轮补录：RNA治疗与mRNA医学；待本地复核。；日期补齐：Crossref 2009-07-26 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1141", "title": "《Identifying lncRNA–miRNA–mRNA networks to investigate Alzheimer’s disease pathogenesis and therapy strategy》论文发表", "date_start": "2020-02-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕RNA治疗与mRNA医学报告或讨论可复核的学术证据。", "summary": "该节点将RNA治疗与mRNA医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2027" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 387 轮补录：RNA治疗与mRNA医学；待本地复核。；日期补齐：Crossref 2020-02-07 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1142", "title": "《Tumours might be sensitized to immune therapy by COVID mRNA vaccines》论文发表", "date_start": "2025-10-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕RNA治疗与mRNA医学报告或讨论可复核的学术证据。", "summary": "该节点将RNA治疗与mRNA医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2028" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 387 轮补录：RNA治疗与mRNA医学；待本地复核。；日期补齐：Crossref 2025-10-22 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1143", "title": "《mRNA therapy is safe for treating the inherited metabolic condition propionic acidaemia》论文发表", "date_start": "2024-05-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕RNA治疗与mRNA医学报告或讨论可复核的学术证据。", "summary": "该节点将RNA治疗与mRNA医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2029" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 387 轮补录：RNA治疗与mRNA医学；待本地复核。；日期补齐：Crossref 2024-05-17 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1144", "title": "《Targeted mRNA therapy tackles deadly pregnancy condition in mice》论文发表", "date_start": "2024-12-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "technology", "claim": "该文献围绕RNA治疗与mRNA医学报告或讨论可复核的学术证据。", "summary": "该节点将RNA治疗与mRNA医学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2030" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 387 轮补录：RNA治疗与mRNA医学；待本地复核。；日期补齐：Crossref 2024-12-11 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1145", "title": "《Personalized medicine: Special treatment》论文发表", "date_start": "2014-09-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕精准医疗与个体化报告或讨论可复核的学术证据。", "summary": "该节点将精准医疗与个体化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2031" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 388 轮补录：精准医疗与个体化；待本地复核。；日期补齐：Crossref 2014-09-10 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1146", "title": "《Metagenomics and Personalized Medicine》论文发表", "date_start": "2011-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕精准医疗与个体化报告或讨论可复核的学术证据。", "summary": "该节点将精准医疗与个体化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2032" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 388 轮补录：精准医疗与个体化；待本地复核。；日期补齐：Crossref 2011-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1147", "title": "《Personalized ranges for blood-test results enable precision diagnostics》论文发表", "date_start": "2024-12-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕精准医疗与个体化报告或讨论可复核的学术证据。", "summary": "该节点将精准医疗与个体化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2033" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 388 轮补录：精准医疗与个体化；待本地复核。；日期补齐：Crossref 2024-12-11 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1148", "title": "《Britain to launch personalized medicine project》论文发表", "date_start": "2011-08-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕精准医疗与个体化报告或讨论可复核的学术证据。", "summary": "该节点将精准医疗与个体化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2034" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 388 轮补录：精准医疗与个体化；待本地复核。；日期补齐：Crossref 2011-08-26 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1149", "title": "《Redefining Clinical Trials: The Age of Personalized Medicine》论文发表", "date_start": "2012-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕精准医疗与个体化报告或讨论可复核的学术证据。", "summary": "该节点将精准医疗与个体化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2035" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 388 轮补录：精准医疗与个体化；待本地复核。；日期补齐：Crossref 2012-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1150", "title": "《The role of Hsp70 in oxi-inflamm-aging and its use as a potential biomarker of lifespan》论文发表", "date_start": "2015-09-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物标志物与寿命预测报告或讨论可复核的学术证据。", "summary": "该节点将生物标志物与寿命预测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2036" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 389 轮补录：生物标志物与寿命预测；待本地复核。；日期补齐：Crossref 2015-09-19 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1151", "title": "《DNA methylation entropy is a biomarker for aging》论文发表", "date_start": "2025-03-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物标志物与寿命预测报告或讨论可复核的学术证据。", "summary": "该节点将生物标志物与寿命预测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2037" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 389 轮补录：生物标志物与寿命预测；待本地复核。；日期补齐：Crossref 2025-03-12 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1152", "title": "《NODULE DILEMMA: PROTEOMIC BIOMARKER DISCORDANCE WITH PET RESULTS》论文发表", "date_start": "2021-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物标志物与寿命预测报告或讨论可复核的学术证据。", "summary": "该节点将生物标志物与寿命预测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2038" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 389 轮补录：生物标志物与寿命预测；待本地复核。；日期补齐：Crossref 2021-10 (published-print, month, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1153", "title": "《A novel clinical biomarker-based Physiology Healthy Aging Index and risk of all-cause and cause-specific mortality: A 20-year prospective cohort study》论文发表", "date_start": "2025-12-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物标志物与寿命预测报告或讨论可复核的学术证据。", "summary": "该节点将生物标志物与寿命预测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2039" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 389 轮补录：生物标志物与寿命预测；待本地复核。；日期补齐：Crossref 2025-12-06 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1154", "title": "《Neuroimaging-derived brain-age: an ageing biomarker?》论文发表", "date_start": "2017-08-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕生物标志物与寿命预测报告或讨论可复核的学术证据。", "summary": "该节点将生物标志物与寿命预测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2040" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 389 轮补录：生物标志物与寿命预测；待本地复核。；日期补齐：Crossref 2017-08-30 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1155", "title": "《Dermatologist-level classification of skin cancer with deep neural networks》论文发表", "date_start": "2017-01-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕影像诊断与健康监测报告或讨论可复核的学术证据。", "summary": "该节点将影像诊断与健康监测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2041" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 390 轮补录：影像诊断与健康监测；待本地复核。；日期补齐：Crossref 2017-01-25 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1156", "title": "《International evaluation of an AI system for breast cancer screening》论文发表", "date_start": "2020-01-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕影像诊断与健康监测报告或讨论可复核的学术证据。", "summary": "该节点将影像诊断与健康监测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2042" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 390 轮补录：影像诊断与健康监测；待本地复核。；日期补齐：Crossref 2020-01-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1157", "title": "《End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography》论文发表", "date_start": "2019-05-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕影像诊断与健康监测报告或讨论可复核的学术证据。", "summary": "该节点将影像诊断与健康监测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2043" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 390 轮补录：影像诊断与健康监测；待本地复核。；日期补齐：Crossref 2019-05-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1158", "title": "《A survey on deep learning in medical image analysis》论文发表", "date_start": "2017-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕影像诊断与健康监测报告或讨论可复核的学术证据。", "summary": "该节点将影像诊断与健康监测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2044" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 390 轮补录：影像诊断与健康监测；待本地复核。；日期补齐：Crossref 2017-12 (published-print, month, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1159", "title": "《CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning》论文发表", "date_start": "2017", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕影像诊断与健康监测报告或讨论可复核的学术证据。", "summary": "该节点将影像诊断与健康监测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2045" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 390 轮补录：影像诊断与健康监测；待本地复核。", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-07T07:37:43Z" }, { "event_id": "HIT-TEC-1160", "title": "《Use of Wearable Monitoring Devices to Change Health Behavior》论文发表", "date_start": "2015-05-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕可穿戴设备与连续监测报告或讨论可复核的学术证据。", "summary": "该节点将可穿戴设备与连续监测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2046" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 391 轮补录：可穿戴设备与连续监测；待本地复核。；日期补齐：Crossref 2015-05-12 (published-print, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1161", "title": "《Silk-based wearable devices for health monitoring and medical treatment》论文发表", "date_start": "2024-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕可穿戴设备与连续监测报告或讨论可复核的学术证据。", "summary": "该节点将可穿戴设备与连续监测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2047" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 391 轮补录：可穿戴设备与连续监测；待本地复核。；日期补齐：Crossref 2024-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1162", "title": "《Use of Wearable Monitoring Devices to Change Health Behavior—Reply》论文发表", "date_start": "2015-05-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕可穿戴设备与连续监测报告或讨论可复核的学术证据。", "summary": "该节点将可穿戴设备与连续监测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2048" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 391 轮补录：可穿戴设备与连续监测；待本地复核。；日期补齐：Crossref 2015-05-12 (published-print, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1163", "title": "《Meaningful digital biomarkers derived from wearable sensors to predict daily fatigue in multiple sclerosis patients and healthy controls》论文发表", "date_start": "2024-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕可穿戴设备与连续监测报告或讨论可复核的学术证据。", "summary": "该节点将可穿戴设备与连续监测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2049" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 391 轮补录：可穿戴设备与连续监测；待本地复核。；日期补齐：Crossref 2024-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-TEC-1164", "title": "《A wearable ultrasound patch for continuous heart imaging》论文发表", "date_start": "2023-01-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "technology", "claim": "该文献围绕可穿戴设备与连续监测报告或讨论可复核的学术证据。", "summary": "该节点将可穿戴设备与连续监测的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2050" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 391 轮补录：可穿戴设备与连续监测；待本地复核。；日期补齐：Crossref 2023-01-25 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1165", "title": "《Virtually Perfect? Telemedicine for Covid-19》论文发表", "date_start": "2020-04-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该文献围绕远程医疗与数字照护报告或讨论可复核的学术证据。", "summary": "该节点将远程医疗与数字照护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2051" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 392 轮补录：远程医疗与数字照护；待本地复核。；日期补齐：Crossref 2020-04-30 (published-print, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1166", "title": "《Telehealth transformation: COVID-19 and the rise of virtual care》论文发表", "date_start": "2020-05-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该文献围绕远程医疗与数字照护报告或讨论可复核的学术证据。", "summary": "该节点将远程医疗与数字照护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2052" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 392 轮补录：远程医疗与数字照护；待本地复核。；日期补齐：Crossref 2020-05-17 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1167", "title": "《Virtual Care, Telemedicine Visits, and Real Connection in the Era of COVID-19》论文发表", "date_start": "2021-02-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该文献围绕远程医疗与数字照护报告或讨论可复核的学术证据。", "summary": "该节点将远程医疗与数字照护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2053" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 392 轮补录：远程医疗与数字照护；待本地复核。；日期补齐：Crossref 2021-02-02 (published-print, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1168", "title": "《On-Demand, Virtual Health Care During COVID-19: Clinician Redeployment and Telemedicine Utilization in a Children's Health System》论文发表", "date_start": "2021-10-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该文献围绕远程医疗与数字照护报告或讨论可复核的学术证据。", "summary": "该节点将远程医疗与数字照护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2054" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 392 轮补录：远程医疗与数字照护；待本地复核。；日期补齐：Crossref 2021-10-01 (published-print, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-TEC-1169", "title": "《Digital health equity for older populations》论文发表", "date_start": "2023-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "technology", "claim": "该文献围绕远程医疗与数字照护报告或讨论可复核的学术证据。", "summary": "该节点将远程医疗与数字照护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2055" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 392 轮补录：远程医疗与数字照护；待本地复核。；日期补齐：Crossref 2023-07 (published-print, month, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-POL-087", "title": "《Data standards urged》论文发表", "date_start": "2012-12-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕健康数据互操作报告或讨论可复核的学术证据。", "summary": "该节点将健康数据互操作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2056" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 393 轮补录：健康数据互操作；待本地复核。；日期补齐：Crossref 2012-12-05 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-088", "title": "《Minimum standards set out for gene-expression data》论文发表", "date_start": "2002-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕健康数据互操作报告或讨论可复核的学术证据。", "summary": "该节点将健康数据互操作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2057" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 393 轮补录：健康数据互操作；待本地复核。；日期补齐：Crossref 2002-02-28 (published-print, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-089", "title": "《UK's food standards agency will report to health minister》论文发表", "date_start": "1998-01-22", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕健康数据互操作报告或讨论可复核的学术证据。", "summary": "该节点将健康数据互操作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2058" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 393 轮补录：健康数据互操作；待本地复核。；日期补齐：Crossref 1998-01-22 (published-print, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-090", "title": "《Progress being made on standards for use in data sharing》论文发表", "date_start": "2008-11-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕健康数据互操作报告或讨论可复核的学术证据。", "summary": "该节点将健康数据互操作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2059" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 393 轮补录：健康数据互操作；待本地复核。；日期补齐：Crossref 2008-11-05 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-POL-091", "title": "《Data sharing: standards are on the rise》论文发表", "date_start": "2022-10-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "policy", "claim": "该文献围绕健康数据互操作报告或讨论可复核的学术证据。", "summary": "该节点将健康数据互操作的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2060" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 393 轮补录：健康数据互操作；待本地复核。；日期补齐：Crossref 2022-10-11 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-528", "title": "《Updating Cost-Effectiveness — The Curious Resilience of the $50,000-per-QALY Threshold》论文发表", "date_start": "2014-08-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕健康经济学与价值报告或讨论可复核的学术证据。", "summary": "该节点将健康经济学与价值的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2061" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 394 轮补录：健康经济学与价值；待本地复核。；日期补齐：Crossref 2014-08-28 (published-print, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-529", "title": "《Recommendations for Conduct, Methodological Practices, and Reporting of Cost-effectiveness Analyses》论文发表", "date_start": "2016-09-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕健康经济学与价值报告或讨论可复核的学术证据。", "summary": "该节点将健康经济学与价值的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2062" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 394 轮补录：健康经济学与价值；待本地复核。；日期补齐：Crossref 2016-09-13 (published-print, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-530", "title": "《The value of value in health economic modelling》论文发表", "date_start": "2013-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕健康经济学与价值报告或讨论可复核的学术证据。", "summary": "该节点将健康经济学与价值的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2063" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 394 轮补录：健康经济学与价值；待本地复核。；日期补齐：Crossref 2013-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-531", "title": "《History of the international societies in health technology assessment: International Society for Technology Assessment in Health Care and Health Technology Assessment International》论文发表", "date_start": "2009-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕健康经济学与价值报告或讨论可复核的学术证据。", "summary": "该节点将健康经济学与价值的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2064" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 394 轮补录：健康经济学与价值；待本地复核。；日期补齐：Crossref 2009-07-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-532", "title": "《RS2 Cost-Effectiveness of End-of-Life, Life-Extending Interventions: NICE's Cost-Effectiveness Threshold Explored》论文发表", "date_start": "2011-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕健康经济学与价值报告或讨论可复核的学术证据。", "summary": "该节点将健康经济学与价值的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2065" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 394 轮补录：健康经济学与价值；待本地复核。；日期补齐：Crossref 2011-11 (published-print, month, v3)", "created_at": "2026-08-07T07:37:43Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-533", "title": "《APOCALYPSE NO: Population Aging and The Future of Health Care Systems》论文发表", "date_start": "2010-11-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕老龄化社会与制度报告或讨论可复核的学术证据。", "summary": "该节点将老龄化社会与制度的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2066" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 395 轮补录：老龄化社会与制度；待本地复核。；日期补齐：Crossref 2010-11-29 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-534", "title": "《Navigating the long road to long‐term care funding reform》论文发表", "date_start": "2010-12-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕老龄化社会与制度报告或讨论可复核的学术证据。", "summary": "该节点将老龄化社会与制度的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2067" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 395 轮补录：老龄化社会与制度；待本地复核。；日期补齐：Crossref 2010-12-14 (published-print, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-535", "title": "《World Health Organisation, Ageing and Work Capacity, WHO Technical Report Series 835, World Health Organisation, Geneva, 1993, 49 pp., pbk Sw.F. 10, price in developing countries Sw.F. 7, ISBN 9 241 20835 X.》论文发表", "date_start": "2008-11-14", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕老龄化社会与制度报告或讨论可复核的学术证据。", "summary": "该节点将老龄化社会与制度的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2068" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 395 轮补录：老龄化社会与制度；待本地复核。；日期补齐：Crossref 2008-11-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-536", "title": "《The World Health Organization perspective on gender, ageing and health》论文发表", "date_start": "1998-03", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕老龄化社会与制度报告或讨论可复核的学术证据。", "summary": "该节点将老龄化社会与制度的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2069" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 395 轮补录：老龄化社会与制度；待本地复核。；日期补齐：Crossref 1998-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-537", "title": "《World Health Report 2000: Challenging a World View》论文发表", "date_start": "2000-10-01", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕老龄化社会与制度报告或讨论可复核的学术证据。", "summary": "该节点将老龄化社会与制度的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2070" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 395 轮补录：老龄化社会与制度；待本地复核。；日期补齐：Crossref 2000-10-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-538", "title": "《Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortex》论文发表", "date_start": "1990-09", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长期护理与照护体系报告或讨论可复核的学术证据。", "summary": "该节点将长期护理与照护体系的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2071" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 396 轮补录：长期护理与照护体系；待本地复核。；日期补齐：Crossref 1990-09 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-539", "title": "《Short-term tests validate long-term estimates of climate change》论文发表", "date_start": "2020-05-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长期护理与照护体系报告或讨论可复核的学术证据。", "summary": "该节点将长期护理与照护体系的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2072" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 396 轮补录：长期护理与照护体系；待本地复核。；日期补齐：Crossref 2020-05-26 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-540", "title": "《Long-distance long-term depression》论文发表", "date_start": "1997-07-31", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长期护理与照护体系报告或讨论可复核的学术证据。", "summary": "该节点将长期护理与照护体系的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2073" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 396 轮补录：长期护理与照护体系；待本地复核。；日期补齐：Crossref 1997-07-31 (published-print, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-541", "title": "《Long-term memory gets wiped》论文发表", "date_start": "2007-08-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长期护理与照护体系报告或讨论可复核的学术证据。", "summary": "该节点将长期护理与照护体系的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2074" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 396 轮补录：长期护理与照护体系；待本地复核。；日期补齐：Crossref 2007-08-16 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-542", "title": "《Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change》论文发表", "date_start": "1995-12", "date_type": "approx", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕长期护理与照护体系报告或讨论可复核的学术证据。", "summary": "该节点将长期护理与照护体系的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2075" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 396 轮补录：长期护理与照护体系；待本地复核。；日期补齐：Crossref 1995-12 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-543", "title": "《The Lancet Commission on Palliative Care and Pain Relief—findings, recommendations, and future directions》论文发表", "date_start": "2018-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕临终关怀与死亡文化报告或讨论可复核的学术证据。", "summary": "该节点将临终关怀与死亡文化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2076" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 397 轮补录：临终关怀与死亡文化；待本地复核。；日期补齐：Crossref 2018-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-544", "title": "《Prioritising palliative care》论文发表", "date_start": "2014-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕临终关怀与死亡文化报告或讨论可复核的学术证据。", "summary": "该节点将临终关怀与死亡文化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2077" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 397 轮补录：临终关怀与死亡文化；待本地复核。；日期补齐：Crossref 2014-05 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-545", "title": "《Closing the divide: the Harvard Global Equity Initiative–Lancet Commission on global access to pain control and palliative care》论文发表", "date_start": "2015-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕临终关怀与死亡文化报告或讨论可复核的学术证据。", "summary": "该节点将临终关怀与死亡文化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2078" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 397 轮补录：临终关怀与死亡文化；待本地复核。；日期补齐：Crossref 2015-08 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-546", "title": "《Paediatric palliative care》论文发表", "date_start": "2008-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕临终关怀与死亡文化报告或讨论可复核的学术证据。", "summary": "该节点将临终关怀与死亡文化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2079" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 397 轮补录：临终关怀与死亡文化；待本地复核。；日期补齐：Crossref 2008-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-547", "title": "《Report of the Lancet Commission on the Value of Death: bringing death back into life》论文发表", "date_start": "2022-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕临终关怀与死亡文化报告或讨论可复核的学术证据。", "summary": "该节点将临终关怀与死亡文化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2080" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 397 轮补录：临终关怀与死亡文化；待本地复核。；日期补齐：Crossref 2022-02 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-548", "title": "《Immortality and Meaning: Reflections on the Makropulos Debate》论文发表", "date_start": "2009-09-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕永生哲学与意义报告或讨论可复核的学术证据。", "summary": "该节点将永生哲学与意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2081" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 398 轮补录：永生哲学与意义；待本地复核。；日期补齐：Crossref 2009-09-16 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-549", "title": "《Death, Immortality, and Meaning in Life》论文发表", "date_start": "2021-02-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕永生哲学与意义报告或讨论可复核的学术证据。", "summary": "该节点将永生哲学与意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2082" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 398 轮补录：永生哲学与意义；待本地复核。；日期补齐：Crossref 2021-02-02 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-550", "title": "《Reflections on Meaning and Immortality》论文发表", "date_start": "2021-12-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕永生哲学与意义报告或讨论可复核的学术证据。", "summary": "该节点将永生哲学与意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2083" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 398 轮补录：永生哲学与意义；待本地复核。；日期补齐：Crossref 2021-12-13 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-551", "title": "《IMMORTALITY WITHOUT BOREDOM》论文发表", "date_start": "2009-07-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕永生哲学与意义报告或讨论可复核的学术证据。", "summary": "该节点将永生哲学与意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2084" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 398 轮补录：永生哲学与意义；待本地复核。；日期补齐：Crossref 2009-07-14 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-552", "title": "《IMMORTALITY, HUMAN NATURE, THE VALUE OF LIFE AND THE VALUE OF LIFE EXTENSION》论文发表", "date_start": "2006-10-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕永生哲学与意义报告或讨论可复核的学术证据。", "summary": "该节点将永生哲学与意义的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2085" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 398 轮补录：永生哲学与意义；待本地复核。；日期补齐：Crossref 2006-10-06 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-553", "title": "《Vision of the future》论文发表", "date_start": "1999-10-11", "date_type": "exact", "period_id": "period-20th-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕未来文明愿景报告或讨论可复核的学术证据。", "summary": "该节点将未来文明愿景的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2086" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 399 轮补录：未来文明愿景；待本地复核。；日期补齐：Crossref 1999-10-11 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-554", "title": "《Future vision》论文发表", "date_start": "2017-04-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕未来文明愿景报告或讨论可复核的学术证据。", "summary": "该节点将未来文明愿景的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2087" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 399 轮补录：未来文明愿景；待本地复核。；日期补齐：Crossref 2017-04-06 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-555", "title": "《A vision of our transport future》论文发表", "date_start": "2013-05-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕未来文明愿景报告或讨论可复核的学术证据。", "summary": "该节点将未来文明愿景的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2088" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 399 轮补录：未来文明愿景；待本地复核。；日期补齐：Crossref 2013-05-08 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-556", "title": "《Vision of a personal genomics future》论文发表", "date_start": "2010-01-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕未来文明愿景报告或讨论可复核的学术证据。", "summary": "该节点将未来文明愿景的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2089" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 399 轮补录：未来文明愿景；待本地复核。；日期补齐：Crossref 2010-01-20 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-557", "title": "《Ancient civilization goes online》论文发表", "date_start": "2003-04-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "thought", "claim": "该文献围绕未来文明愿景报告或讨论可复核的学术证据。", "summary": "该节点将未来文明愿景的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2090" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 399 轮补录：未来文明愿景；待本地复核。；日期补齐：Crossref 2003-04-01 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-THT-558", "title": "《Social determinants of health inequalities》论文发表", "date_start": "2005-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕人类基础设施总体评估报告或讨论可复核的学术证据。", "summary": "该节点将人类基础设施总体评估的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2091" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 400 轮补录：人类基础设施总体评估；待本地复核。；日期补齐：Crossref 2005-03 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-559", "title": "《Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019》论文发表", "date_start": "2020-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕人类基础设施总体评估报告或讨论可复核的学术证据。", "summary": "该节点将人类基础设施总体评估的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2092" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 400 轮补录：人类基础设施总体评估；待本地复核。；日期补齐：Crossref 2020-10 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-560", "title": "《Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017》论文发表", "date_start": "2018-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕人类基础设施总体评估报告或讨论可复核的学术证据。", "summary": "该节点将人类基础设施总体评估的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2093" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 400 轮补录：人类基础设施总体评估；待本地复核。；日期补齐：Crossref 2018-11 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-561", "title": "《Universal Health Coverage: realistic and achievable?》论文发表", "date_start": "2019-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕人类基础设施总体评估报告或讨论可复核的学术证据。", "summary": "该节点将人类基础设施总体评估的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2094" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 400 轮补录：人类基础设施总体评估；待本地复核。；日期补齐：Crossref 2019-01 (published-print, month, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-THT-562", "title": "《Toward a theory-led meta-framework for implementing health system resilience analysis studies: a systematic review and critical interpretive synthesis》论文发表", "date_start": "2022-02-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "thought", "claim": "该文献围绕人类基础设施总体评估报告或讨论可复核的学术证据。", "summary": "该节点将人类基础设施总体评估的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2095" ], "evidence_grade": "I", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "健康工程、转化医学与总体基础设施", "notes": "第 400 轮补录：人类基础设施总体评估；待本地复核。；日期补齐：Crossref 2022-02-12 (published-online, day, v3)", "created_at": "2026-08-07T07:37:44Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-025", "title": "《Waste clearance shapes aging brain health》论文发表", "date_start": "2025-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胶质淋巴系统与脑废弃物清除报告或讨论可复核的学术证据。", "summary": "该节点将胶质淋巴系统与脑废弃物清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2096" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 401 轮补录：胶质淋巴系统与脑废弃物清除；待本地复核。；日期补齐：Crossref 2025-01 (published-print, month, v3)", "created_at": "2026-08-07T08:21:58Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-026", "title": "《Neuronal activity drives glymphatic waste clearance》论文发表", "date_start": "2024-04-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胶质淋巴系统与脑废弃物清除报告或讨论可复核的学术证据。", "summary": "该节点将胶质淋巴系统与脑废弃物清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2097" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 401 轮补录：胶质淋巴系统与脑废弃物清除；待本地复核。；日期补齐：Crossref 2024-04-15 (published-online, day, v3)", "created_at": "2026-08-07T08:21:58Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-027", "title": "《Impaired glymphatic clearance as a mechanistic link between brain aging and neurodegenerative disease pathogenesis》论文发表", "date_start": "2026-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胶质淋巴系统与脑废弃物清除报告或讨论可复核的学术证据。", "summary": "该节点将胶质淋巴系统与脑废弃物清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2098" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 401 轮补录：胶质淋巴系统与脑废弃物清除；待本地复核。；日期补齐：Crossref 2026-08 (published-print, month, v3)", "created_at": "2026-08-07T08:21:58Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-028", "title": "《Imaging of brain clearance pathways via MRI assessment of the glymphatic system》论文发表", "date_start": "2023-12-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胶质淋巴系统与脑废弃物清除报告或讨论可复核的学术证据。", "summary": "该节点将胶质淋巴系统与脑废弃物清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2099" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 401 轮补录：胶质淋巴系统与脑废弃物清除；待本地复核。；日期补齐：Crossref 2023-12-26 (published-online, day, v3)", "created_at": "2026-08-07T08:21:58Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-029", "title": "《Brain glymphatic clearance is impaired in a rat model of cirrhosis》论文发表", "date_start": "2017", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胶质淋巴系统与脑废弃物清除报告或讨论可复核的学术证据。", "summary": "该节点将胶质淋巴系统与脑废弃物清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2100" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 401 轮补录：胶质淋巴系统与脑废弃物清除；待本地复核。；日期补齐：Crossref 2017 (published-print, year, v3)", "created_at": "2026-08-07T08:21:58Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-030", "title": "《Compartmentalized ocular lymphatic system mediates eye–brain immunity》论文发表", "date_start": "2024-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脑膜淋巴系统与脑免疫边界报告或讨论可复核的学术证据。", "summary": "该节点将脑膜淋巴系统与脑免疫边界的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2101" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 402 轮补录：脑膜淋巴系统与脑免疫边界；待本地复核。；日期补齐：Crossref 2024-02-28 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-031", "title": "《Role of meningeal lymphatic vessels in brain homeostasis》论文发表", "date_start": "2025-06-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脑膜淋巴系统与脑免疫边界报告或讨论可复核的学术证据。", "summary": "该节点将脑膜淋巴系统与脑免疫边界的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2102" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 402 轮补录：脑膜淋巴系统与脑免疫边界；待本地复核。；日期补齐：Crossref 2025-06-19 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-032", "title": "《Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis》论文发表", "date_start": "2020-09-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脑膜淋巴系统与脑免疫边界报告或讨论可复核的学术证据。", "summary": "该节点将脑膜淋巴系统与脑免疫边界的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2103" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 402 轮补录：脑膜淋巴系统与脑免疫边界；待本地复核。；日期补齐：Crossref 2020-09-10 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-033", "title": "《Disrupted drainage in the aging brain: Meningeal lymphatic decline as a convergent axis of vulnerability》论文发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脑膜淋巴系统与脑免疫边界报告或讨论可复核的学术证据。", "summary": "该节点将脑膜淋巴系统与脑免疫边界的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2104" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 402 轮补录：脑膜淋巴系统与脑免疫边界；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-034", "title": "《Meningeal lymphatic flow slows after mild traumatic brain injury》论文发表", "date_start": "2020-09-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脑膜淋巴系统与脑免疫边界报告或讨论可复核的学术证据。", "summary": "该节点将脑膜淋巴系统与脑免疫边界的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2105" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 402 轮补录：脑膜淋巴系统与脑免疫边界；待本地复核。；日期补齐：Crossref 2020-09-24 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-035", "title": "《Aging and the blood-brain barrier》论文发表", "date_start": "1994-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕血脑屏障衰老与转运维持报告或讨论可复核的学术证据。", "summary": "该节点将血脑屏障衰老与转运维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2106" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 403 轮补录：血脑屏障衰老与转运维持；待本地复核。；日期补齐：Crossref 1994-11 (published-print, month, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-036", "title": "《Healthy aging and the blood–brain barrier》论文发表", "date_start": "2021-03-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕血脑屏障衰老与转运维持报告或讨论可复核的学术证据。", "summary": "该节点将血脑屏障衰老与转运维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2107" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 403 轮补录：血脑屏障衰老与转运维持；待本地复核。；日期补齐：Crossref 2021-03-15 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-037", "title": "《Copper transport to the brain by the blood-brain barrier and blood-CSF barrier》论文发表", "date_start": "2009-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕血脑屏障衰老与转运维持报告或讨论可复核的学术证据。", "summary": "该节点将血脑屏障衰老与转运维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2108" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 403 轮补录：血脑屏障衰老与转运维持；待本地复核。；日期补齐：Crossref 2009-01 (published-print, month, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-038", "title": "《Peptide transport across the blood-brain barrier》论文发表", "date_start": "1990-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕血脑屏障衰老与转运维持报告或讨论可复核的学术证据。", "summary": "该节点将血脑屏障衰老与转运维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2109" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 403 轮补录：血脑屏障衰老与转运维持；待本地复核。；日期补齐：Crossref 1990-08 (published-print, month, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-039", "title": "《Development, maintenance and disruption of the blood-brain barrier》论文发表", "date_start": "2013-12-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕血脑屏障衰老与转运维持报告或讨论可复核的学术证据。", "summary": "该节点将血脑屏障衰老与转运维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2110" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 403 轮补录：血脑屏障衰老与转运维持；待本地复核。；日期补齐：Crossref 2013-12-05 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-040", "title": "《Cerebrospinal fluid dynamics and brain function regulation: from homeostasis to neurological disorders》论文发表", "date_start": "2026-02-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脑脊液动力学与神经稳态报告或讨论可复核的学术证据。", "summary": "该节点将脑脊液动力学与神经稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2111" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 404 轮补录：脑脊液动力学与神经稳态；待本地复核。；日期补齐：Crossref 2026-02-10 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-041", "title": "《Pulsatile Cerebrospinal Fluid Dynamics in the Human Brain》论文发表", "date_start": "2005-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脑脊液动力学与神经稳态报告或讨论可复核的学术证据。", "summary": "该节点将脑脊液动力学与神经稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2112" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 404 轮补录：脑脊液动力学与神经稳态；待本地复核。；日期补齐：Crossref 2005-04 (published-print, month, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-042", "title": "《Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance》论文发表", "date_start": "2024-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脑脊液动力学与神经稳态报告或讨论可复核的学术证据。", "summary": "该节点将脑脊液动力学与神经稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2113" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 404 轮补录：脑脊液动力学与神经稳态；待本地复核。；日期补齐：Crossref 2024-02-28 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-043", "title": "《AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis》论文发表", "date_start": "2019-02-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脑脊液动力学与神经稳态报告或讨论可复核的学术证据。", "summary": "该节点将脑脊液动力学与神经稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2114" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 404 轮补录：脑脊液动力学与神经稳态；待本地复核。；日期补齐：Crossref 2019-02-24 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-044", "title": "《The Potential Roles of Blood–Brain Barrier and Blood–Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis》论文发表", "date_start": "2021-05-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脑脊液动力学与神经稳态报告或讨论可复核的学术证据。", "summary": "该节点将脑脊液动力学与神经稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2115" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "分子与细胞维护、神经与免疫工程", "notes": "第 404 轮补录：脑脊液动力学与神经稳态；待本地复核。；日期补齐：Crossref 2021-05-27 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-045", "title": "《AGING AND CIRCADIAN CLOCK》论文发表", "date_start": "2023-12-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕昼夜节律与生物钟老化报告或讨论可复核的学术证据。", "summary": "该节点将昼夜节律与生物钟老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2116" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 405 轮补录：昼夜节律与生物钟老化；待本地复核。；日期补齐：Crossref 2023-12-21 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-046", "title": "《0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions》论文发表", "date_start": "2024-04-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕昼夜节律与生物钟老化报告或讨论可复核的学术证据。", "summary": "该节点将昼夜节律与生物钟老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2117" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 405 轮补录：昼夜节律与生物钟老化；待本地复核。；日期补齐：Crossref 2024-04-20 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-047", "title": "《Aging attenuates the ovarian circadian rhythm》论文发表", "date_start": "2020-09-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕昼夜节律与生物钟老化报告或讨论可复核的学术证据。", "summary": "该节点将昼夜节律与生物钟老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2118" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 405 轮补录：昼夜节律与生物钟老化；待本地复核。；日期补齐：Crossref 2020-09-14 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-048", "title": "《Crosstalk Between Aging, Circadian Rhythm, and Melatonin》论文发表", "date_start": "2023-12-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕昼夜节律与生物钟老化报告或讨论可复核的学术证据。", "summary": "该节点将昼夜节律与生物钟老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2119" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 405 轮补录：昼夜节律与生物钟老化；待本地复核。；日期补齐：Crossref 2023-12-14 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-049", "title": "《CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis》论文发表", "date_start": "2017-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕昼夜节律与生物钟老化报告或讨论可复核的学术证据。", "summary": "该节点将昼夜节律与生物钟老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2120" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 405 轮补录：昼夜节律与生物钟老化；待本地复核。；日期补齐：Crossref 2017-10 (published-print, month, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-050", "title": "《Subjective sleep quality and sleep architecture in aging》论文发表", "date_start": "2019-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕睡眠结构与恢复性睡眠报告或讨论可复核的学术证据。", "summary": "该节点将睡眠结构与恢复性睡眠的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2121" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 406 轮补录：睡眠结构与恢复性睡眠；待本地复核。；日期补齐：Crossref 2019-12 (published-print, month, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-051", "title": "《Association between restorative sleep and sleep fragmentation in obstructive sleep apnea》论文发表", "date_start": "2026-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕睡眠结构与恢复性睡眠报告或讨论可复核的学术证据。", "summary": "该节点将睡眠结构与恢复性睡眠的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2122" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 406 轮补录：睡眠结构与恢复性睡眠；待本地复核。；日期补齐：Crossref 2026-02 (published-print, month, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-052", "title": "《Severe sleep disordered breathing disrupts sleep architecture》论文发表", "date_start": "2019-10-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕睡眠结构与恢复性睡眠报告或讨论可复核的学术证据。", "summary": "该节点将睡眠结构与恢复性睡眠的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2123" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 406 轮补录：睡眠结构与恢复性睡眠；待本地复核。；日期补齐：Crossref 2019-10-03 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-053", "title": "《Resilience and Readiness through Restorative Sleep》论文发表", "date_start": "2015-02-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕睡眠结构与恢复性睡眠报告或讨论可复核的学术证据。", "summary": "该节点将睡眠结构与恢复性睡眠的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2124" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 406 轮补录：睡眠结构与恢复性睡眠；待本地复核。；日期补齐：Crossref 2015-02-01 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-054", "title": "《Effects of oxybate on sleep, sleep architecture, and disrupted nighttime sleep》论文发表", "date_start": "2024-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕睡眠结构与恢复性睡眠报告或讨论可复核的学术证据。", "summary": "该节点将睡眠结构与恢复性睡眠的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2125" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 406 轮补录：睡眠结构与恢复性睡眠；待本地复核。；日期补齐：Crossref 2024-02 (published-print, month, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-055", "title": "《How Aging Affects Sleep-Dependent Memory Consolidation?》论文发表", "date_start": "2012", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕深睡眠与记忆巩固报告或讨论可复核的学术证据。", "summary": "该节点将深睡眠与记忆巩固的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2126" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与神经维护", "notes": "第 407 轮补录：深睡眠与记忆巩固；待本地复核。；日期补齐：Crossref 2012 (published-online, year, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-056", "title": "《Sleep-dependent prospective memory consolidation is impaired with aging》论文发表", "date_start": "2021-03-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕深睡眠与记忆巩固报告或讨论可复核的学术证据。", "summary": "该节点将深睡眠与记忆巩固的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2127" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与神经维护", "notes": "第 407 轮补录：深睡眠与记忆巩固；待本地复核。；日期补齐：Crossref 2021-03-23 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-057", "title": "《046 Sleep-dependent prospective memory consolidation is impaired with aging》论文发表", "date_start": "2021-05-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕深睡眠与记忆巩固报告或讨论可复核的学术证据。", "summary": "该节点将深睡眠与记忆巩固的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2128" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与神经维护", "notes": "第 407 轮补录：深睡眠与记忆巩固；待本地复核。；日期补齐：Crossref 2021-05-03 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-058", "title": "《Sleep and Social Memory Consolidation》论文发表", "date_start": "2015", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕深睡眠与记忆巩固报告或讨论可复核的学术证据。", "summary": "该节点将深睡眠与记忆巩固的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2129" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与神经维护", "notes": "第 407 轮补录：深睡眠与记忆巩固；待本地复核。；日期补齐：Crossref 2015 (published-online, year, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-059", "title": "《Sleep enhances memory consolidation in children》论文发表", "date_start": "2013-12-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕深睡眠与记忆巩固报告或讨论可复核的学术证据。", "summary": "该节点将深睡眠与记忆巩固的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2130" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与神经维护", "notes": "第 407 轮补录：深睡眠与记忆巩固；待本地复核。；日期补齐：Crossref 2013-12-16 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-060", "title": "《Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement》论文发表", "date_start": "2014", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕成年神经发生与脑修复报告或讨论可复核的学术证据。", "summary": "该节点将成年神经发生与脑修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2131" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 408 轮补录：成年神经发生与脑修复；待本地复核。；日期补齐：Crossref 2014 (published-online, year, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-061", "title": "《Adult neurogenesis 20 years later: physiological function vs. brain repair》论文发表", "date_start": "2015-03-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕成年神经发生与脑修复报告或讨论可复核的学术证据。", "summary": "该节点将成年神经发生与脑修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2132" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 408 轮补录：成年神经发生与脑修复；待本地复核。；日期补齐：Crossref 2015-03-06 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-062", "title": "《Adult neurogenesis and its promise as a hope for brain repair》论文发表", "date_start": "2014-06-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕成年神经发生与脑修复报告或讨论可复核的学术证据。", "summary": "该节点将成年神经发生与脑修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2133" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 408 轮补录：成年神经发生与脑修复；待本地复核。；日期补齐：Crossref 2014-06-17 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-063", "title": "《Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair》论文发表", "date_start": "2020-02-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕成年神经发生与脑修复报告或讨论可复核的学术证据。", "summary": "该节点将成年神经发生与脑修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2134" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 408 轮补录：成年神经发生与脑修复；待本地复核。；日期补齐：Crossref 2020-02-12 (published-online, day, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-064", "title": "《Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease》论文发表", "date_start": "2021-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕成年神经发生与脑修复报告或讨论可复核的学术证据。", "summary": "该节点将成年神经发生与脑修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2135" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 408 轮补录：成年神经发生与脑修复；待本地复核。；日期补齐：Crossref 2021-04 (published-print, month, v3)", "created_at": "2026-08-07T08:21:59Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-065", "title": "《Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory》论文发表", "date_start": "2004-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕突触可塑性与长期记忆报告或讨论可复核的学术证据。", "summary": "该节点将突触可塑性与长期记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2136" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与神经维护", "notes": "第 409 轮补录：突触可塑性与长期记忆；待本地复核。；日期补齐：Crossref 2004-02 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-066", "title": "《Long-term synaptic plasticity in hippocampal interneurons》论文发表", "date_start": "2007-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕突触可塑性与长期记忆报告或讨论可复核的学术证据。", "summary": "该节点将突触可塑性与长期记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2137" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与神经维护", "notes": "第 409 轮补录：突触可塑性与长期记忆；待本地复核。；日期补齐：Crossref 2007-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-067", "title": "《Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1》论文发表", "date_start": "2015-01-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕突触可塑性与长期记忆报告或讨论可复核的学术证据。", "summary": "该节点将突触可塑性与长期记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2138" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与神经维护", "notes": "第 409 轮补录：突触可塑性与长期记忆；待本地复核。；日期补齐：Crossref 2015-01-19 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-068", "title": "《Methamphetamine Inhibits Long-Term Memory Acquisition and Synaptic Plasticity by Evoking Endoplasmic Reticulum Stress》论文发表", "date_start": "2021-01-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕突触可塑性与长期记忆报告或讨论可复核的学术证据。", "summary": "该节点将突触可塑性与长期记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2139" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与神经维护", "notes": "第 409 轮补录：突触可塑性与长期记忆；待本地复核。；日期补齐：Crossref 2021-01-14 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-069", "title": "《Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration》论文发表", "date_start": "2014-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕突触可塑性与长期记忆报告或讨论可复核的学术证据。", "summary": "该节点将突触可塑性与长期记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2140" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知与神经维护", "notes": "第 409 轮补录：突触可塑性与长期记忆；待本地复核。；日期补齐：Crossref 2014-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-070", "title": "《Induction of myelin-associated glycoprotein mRNA in experimental remyelination》论文发表", "date_start": "1990-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕髓鞘修复与再髓鞘化报告或讨论可复核的学术证据。", "summary": "该节点将髓鞘修复与再髓鞘化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2141" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 410 轮补录：髓鞘修复与再髓鞘化；待本地复核。；日期补齐：Crossref 1990-04 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-071", "title": "《Remyelination alters the pattern of myelin in the cerebral cortex》论文发表", "date_start": "2020-05-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕髓鞘修复与再髓鞘化报告或讨论可复核的学术证据。", "summary": "该节点将髓鞘修复与再髓鞘化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2142" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 410 轮补录：髓鞘修复与再髓鞘化；待本地复核。；日期补齐：Crossref 2020-05-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-072", "title": "《Targeting the Subventricular Zone to Promote Myelin Repair in the Aging Brain》论文发表", "date_start": "2022-05-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕髓鞘修复与再髓鞘化报告或讨论可复核的学术证据。", "summary": "该节点将髓鞘修复与再髓鞘化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2143" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 410 轮补录：髓鞘修复与再髓鞘化；待本地复核。；日期补齐：Crossref 2022-05-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-073", "title": "《Role of Multifocal Visually Evoked Potential as a Biomarker of Demyelination, Spontaneous Remyelination, and Myelin Repair in Multiple Sclerosis》论文发表", "date_start": "2021-10-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕髓鞘修复与再髓鞘化报告或讨论可复核的学术证据。", "summary": "该节点将髓鞘修复与再髓鞘化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2144" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 410 轮补录：髓鞘修复与再髓鞘化；待本地复核。；日期补齐：Crossref 2021-10-29 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-074", "title": "《Microglia promote remyelination independent of their role in clearing myelin debris》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕髓鞘修复与再髓鞘化报告或讨论可复核的学术证据。", "summary": "该节点将髓鞘修复与再髓鞘化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2145" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 410 轮补录：髓鞘修复与再髓鞘化；待本地复核。；日期补齐：Crossref 2023-12 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-075", "title": "《Spinal Cord Repair: Strategies to Promote Axon Regeneration》论文发表", "date_start": "2001-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕轴突再生与外周神经修复报告或讨论可复核的学术证据。", "summary": "该节点将轴突再生与外周神经修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2146" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 411 轮补录：轴突再生与外周神经修复；待本地复核。；日期补齐：Crossref 2001-02 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-076", "title": "《Neuronal maturation and axon regeneration: unfixing circuitry to enable repair》论文发表", "date_start": "2024-08-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕轴突再生与外周神经修复报告或讨论可复核的学术证据。", "summary": "该节点将轴突再生与外周神经修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2147" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 411 轮补录：轴突再生与外周神经修复；待本地复核。；日期补齐：Crossref 2024-08-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-077", "title": "《Nerve regeneration and nerve repair》论文发表", "date_start": "2013-07-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕轴突再生与外周神经修复报告或讨论可复核的学术证据。", "summary": "该节点将轴突再生与外周神经修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2148" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 411 轮补录：轴突再生与外周神经修复；待本地复核。；日期补齐：Crossref 2013-07-19 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-078", "title": "《Local delivery of FK506 to injured peripheral nerve enhances axon regeneration after surgical nerve repair in rats》论文发表", "date_start": "2019-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕轴突再生与外周神经修复报告或讨论可复核的学术证据。", "summary": "该节点将轴突再生与外周神经修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2149" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 411 轮补录：轴突再生与外周神经修复；待本地复核。；日期补齐：Crossref 2019-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-079", "title": "《PTEN inhibition and axon regeneration and neural repair》论文发表", "date_start": "2015", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕轴突再生与外周神经修复报告或讨论可复核的学术证据。", "summary": "该节点将轴突再生与外周神经修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2150" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 411 轮补录：轴突再生与外周神经修复；待本地复核。；日期补齐：Crossref 2015 (published-print, year, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-080", "title": "《Neurorehabilitation of Spinal Cord Injury》论文发表", "date_start": "1994-01-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕脊髓损伤恢复与神经重建报告或讨论可复核的学术证据。", "summary": "该节点将脊髓损伤恢复与神经重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2151" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 412 轮补录：脊髓损伤恢复与神经重建；待本地复核。；日期补齐：Crossref 1994-01-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-081", "title": "《Spinal cord injury and bladder recovery》论文发表", "date_start": "1996-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕脊髓损伤恢复与神经重建报告或讨论可复核的学术证据。", "summary": "该节点将脊髓损伤恢复与神经重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2152" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 412 轮补录：脊髓损伤恢复与神经重建；待本地复核。；日期补齐：Crossref 1996-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-082", "title": "《The physiological basis of neurorehabilitation - locomotor training after spinal cord injury》论文发表", "date_start": "2013", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕脊髓损伤恢复与神经重建报告或讨论可复核的学术证据。", "summary": "该节点将脊髓损伤恢复与神经重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2153" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 412 轮补录：脊髓损伤恢复与神经重建；待本地复核。；日期补齐：Crossref 2013 (published-print, year, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-083", "title": "《Disuse plasticity limits spinal cord injury recovery》论文发表", "date_start": "2025-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕脊髓损伤恢复与神经重建报告或讨论可复核的学术证据。", "summary": "该节点将脊髓损伤恢复与神经重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2154" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 412 轮补录：脊髓损伤恢复与神经重建；待本地复核。；日期补齐：Crossref 2025-04 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-084", "title": "《Neurologic recovery after traumatic spinal cord injury: data from the model spinal cord injury systems》论文发表", "date_start": "1999-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕脊髓损伤恢复与神经重建报告或讨论可复核的学术证据。", "summary": "该节点将脊髓损伤恢复与神经重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2155" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 412 轮补录：脊髓损伤恢复与神经重建；待本地复核。；日期补齐：Crossref 1999-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-085", "title": "《Macrophages protect against sensory axon loss in peripheral neuropathy》论文发表", "date_start": "2025-02-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕外周神经病变与感觉保留报告或讨论可复核的学术证据。", "summary": "该节点将外周神经病变与感觉保留的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2156" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 413 轮补录：外周神经病变与感觉保留；待本地复核。；日期补齐：Crossref 2025-02-12 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-086", "title": "《Cardiovascular autonomic and peripheral sensory neuropathy in women with obesity》论文发表", "date_start": "2024-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕外周神经病变与感觉保留报告或讨论可复核的学术证据。", "summary": "该节点将外周神经病变与感觉保留的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2157" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 413 轮补录：外周神经病变与感觉保留；待本地复核。；日期补齐：Crossref 2024-07-16 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-087", "title": "《Peripheral Sensory Neuropathy Associates With Micro- or Macroangiopathy》论文发表", "date_start": "2009-02-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕外周神经病变与感觉保留报告或讨论可复核的学术证据。", "summary": "该节点将外周神经病变与感觉保留的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2158" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 413 轮补录：外周神经病变与感觉保留；待本地复核。；日期补齐：Crossref 2009-02-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-088", "title": "《Integrins protect sensory neurons in models of paclitaxel-induced peripheral sensory neuropathy》论文发表", "date_start": "2021-04-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕外周神经病变与感觉保留报告或讨论可复核的学术证据。", "summary": "该节点将外周神经病变与感觉保留的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2159" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 413 轮补录：外周神经病变与感觉保留；待本地复核。；日期补齐：Crossref 2021-04-05 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-089", "title": "《Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy》论文发表", "date_start": "2004-10-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕外周神经病变与感觉保留报告或讨论可复核的学术证据。", "summary": "该节点将外周神经病变与感觉保留的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2160" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "神经修复、再生与认知维护", "notes": "第 413 轮补录：外周神经病变与感觉保留；待本地复核。；日期补齐：Crossref 2004-10-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-090", "title": "《Vestibular Deficits in Neurodegenerative Disorders: Balance, Dizziness, and Spatial Disorientation》论文发表", "date_start": "2017-10-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕前庭平衡与空间定向报告或讨论可复核的学术证据。", "summary": "该节点将前庭平衡与空间定向的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2161" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 414 轮补录：前庭平衡与空间定向；待本地复核。；日期补齐：Crossref 2017-10-26 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-091", "title": "《Impairment of human spatial orientation in the horizontal, but not the vertical plane, due to aging, cognitive decline, or chronic peripheral vestibular loss》论文发表", "date_start": "2025-10-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕前庭平衡与空间定向报告或讨论可复核的学术证据。", "summary": "该节点将前庭平衡与空间定向的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2162" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 414 轮补录：前庭平衡与空间定向；待本地复核。；日期补齐：Crossref 2025-10-09 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-092", "title": "《Perspectives on Aging Vestibular Function》论文发表", "date_start": "2016-01-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕前庭平衡与空间定向报告或讨论可复核的学术证据。", "summary": "该节点将前庭平衡与空间定向的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2163" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 414 轮补录：前庭平衡与空间定向；待本地复核。；日期补齐：Crossref 2016-01-06 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-093", "title": "《Aging with Cerebral Small Vessel Disease and Dizziness: The Importance of Undiagnosed Peripheral Vestibular Disorders》论文发表", "date_start": "2017-06-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕前庭平衡与空间定向报告或讨论可复核的学术证据。", "summary": "该节点将前庭平衡与空间定向的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2164" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 414 轮补录：前庭平衡与空间定向；待本地复核。；日期补齐：Crossref 2017-06-02 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-094", "title": "《Vestibular and Balance Rehabilitation Therapy》论文发表", "date_start": "1993-03-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕前庭平衡与空间定向报告或讨论可复核的学术证据。", "summary": "该节点将前庭平衡与空间定向的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2165" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 414 轮补录：前庭平衡与空间定向；待本地复核。；日期补齐：Crossref 1993-03-01 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-095", "title": "《Molecular marker of cochlear aging and hearing loss in primates》论文发表", "date_start": "2025-09-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕听力保存与耳蜗健康报告或讨论可复核的学术证据。", "summary": "该节点将听力保存与耳蜗健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2166" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 415 轮补录：听力保存与耳蜗健康；待本地复核。；日期补齐：Crossref 2025-09-24 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-096", "title": "《Hearing preservation in cochlear implantation》论文发表", "date_start": "2023-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕听力保存与耳蜗健康报告或讨论可复核的学术证据。", "summary": "该节点将听力保存与耳蜗健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2167" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 415 轮补录：听力保存与耳蜗健康；待本地复核。；日期补齐：Crossref 2023-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-097", "title": "《Hearing Preservation in Elderly Cochlear Implant Recipients》论文发表", "date_start": "2020-02-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕听力保存与耳蜗健康报告或讨论可复核的学术证据。", "summary": "该节点将听力保存与耳蜗健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2168" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 415 轮补录：听力保存与耳蜗健康；待本地复核。；日期补齐：Crossref 2020-02-19 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-098", "title": "《Residual Hearing Preservation After Pediatric Cochlear Implantation》论文发表", "date_start": "2010-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕听力保存与耳蜗健康报告或讨论可复核的学术证据。", "summary": "该节点将听力保存与耳蜗健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2169" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 415 轮补录：听力保存与耳蜗健康；待本地复核。；日期补齐：Crossref 2010-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-099", "title": "《Hearing Preservation in Pediatric Cochlear Implantation》论文发表", "date_start": "2017-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕听力保存与耳蜗健康报告或讨论可复核的学术证据。", "summary": "该节点将听力保存与耳蜗健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2170" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 415 轮补录：听力保存与耳蜗健康；待本地复核。；日期补齐：Crossref 2017-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-100", "title": "《Cochlear Implant Artifacts Removal in EEG-Based Objective Auditory Rehabilitation Assessment》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕人工耳蜗与听觉康复报告或讨论可复核的学术证据。", "summary": "该节点将人工耳蜗与听觉康复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2171" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 416 轮补录：人工耳蜗与听觉康复；待本地复核。；日期补齐：Crossref 2024 (published-print, year, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-101", "title": "《Adult cochlear implant rehabilitation》论文发表", "date_start": "2009-07-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕人工耳蜗与听觉康复报告或讨论可复核的学术证据。", "summary": "该节点将人工耳蜗与听觉康复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2172" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 416 轮补录：人工耳蜗与听觉康复；待本地复核。；日期补齐：Crossref 2009-07-07 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-102", "title": "《Auditory Rehabilitation Following Cochlear Implantation》论文发表", "date_start": "2024-07-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕人工耳蜗与听觉康复报告或讨论可复核的学术证据。", "summary": "该节点将人工耳蜗与听觉康复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2173" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 416 轮补录：人工耳蜗与听觉康复；待本地复核。；日期补齐：Crossref 2024-07-02 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-103", "title": "《Objective electroencephalography-based assessment for auditory rehabilitation of pediatric cochlear implant users》论文发表", "date_start": "2021-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕人工耳蜗与听觉康复报告或讨论可复核的学术证据。", "summary": "该节点将人工耳蜗与听觉康复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2174" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 416 轮补录：人工耳蜗与听觉康复；待本地复核。；日期补齐：Crossref 2021-05 (published-print, month, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-104", "title": "《Auditory rehabilitation with a cochlear implant improves cognitive performance》论文发表", "date_start": "2022-05-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕人工耳蜗与听觉康复报告或讨论可复核的学术证据。", "summary": "该节点将人工耳蜗与听觉康复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2175" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 416 轮补录：人工耳蜗与听觉康复；待本地复核。；日期补齐：Crossref 2022-05-24 (published-online, day, v3)", "created_at": "2026-08-07T08:22:00Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-105", "title": "《Low vision: Rescue, regeneration, restoration and rehabilitation》论文发表", "date_start": "2019-12-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕视觉修复与视网膜重建报告或讨论可复核的学术证据。", "summary": "该节点将视觉修复与视网膜重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2176" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 417 轮补录：视觉修复与视网膜重建；待本地复核。；日期补齐：Crossref 2019-12-13 (published-print, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-106", "title": "《Synaptic repair and vision restoration in advanced degenerating eyes by transplantation of retinal progenitor cells》论文发表", "date_start": "2021-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕视觉修复与视网膜重建报告或讨论可复核的学术证据。", "summary": "该节点将视觉修复与视网膜重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2177" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 417 轮补录：视觉修复与视网膜重建；待本地复核。；日期补齐：Crossref 2021-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-107", "title": "《Focal electrical stimulation of human retinal ganglion cells for vision restoration》论文发表", "date_start": "2022-12-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕视觉修复与视网膜重建报告或讨论可复核的学术证据。", "summary": "该节点将视觉修复与视网膜重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2178" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 417 轮补录：视觉修复与视网膜重建；待本地复核。；日期补齐：Crossref 2022-12-19 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-108", "title": "《Chemical reprogramming of fibroblasts into retinal pigment epithelium cells for vision restoration》论文发表", "date_start": "2025-12-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕视觉修复与视网膜重建报告或讨论可复核的学术证据。", "summary": "该节点将视觉修复与视网膜重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2179" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 417 轮补录：视觉修复与视网膜重建；待本地复核。；日期补齐：Crossref 2025-12-09 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-109", "title": "《In vivo Regeneration of Ganglion Cells for Vision Restoration in Mammalian Retinas》论文发表", "date_start": "2021-10-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕视觉修复与视网膜重建报告或讨论可复核的学术证据。", "summary": "该节点将视觉修复与视网膜重建的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2180" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 417 轮补录：视觉修复与视网膜重建；待本地复核。；日期补齐：Crossref 2021-10-04 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-110", "title": "《Recent Progress in Photoreceptor Cell-Based Therapy for Degenerative Retinal Disease》论文发表", "date_start": "2024-02-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕视网膜细胞治疗与视觉报告或讨论可复核的学术证据。", "summary": "该节点将视网膜细胞治疗与视觉的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2181" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 418 轮补录：视网膜细胞治疗与视觉；待本地复核。；日期补齐：Crossref 2024-02-28 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-111", "title": "《Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy》论文发表", "date_start": "1996-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕视网膜细胞治疗与视觉报告或讨论可复核的学术证据。", "summary": "该节点将视网膜细胞治疗与视觉的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2182" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 418 轮补录：视网膜细胞治疗与视觉；待本地复核。；日期补齐：Crossref 1996-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-112", "title": "《Retinal repair by transplantation of photoreceptor precursors》论文发表", "date_start": "2006-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕视网膜细胞治疗与视觉报告或讨论可复核的学术证据。", "summary": "该节点将视网膜细胞治疗与视觉的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2183" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 418 轮补录：视网膜细胞治疗与视觉；待本地复核。；日期补齐：Crossref 2006-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-113", "title": "《Mesenchymal stem cell therapy for retinal ganglion cell neuroprotection and axon regeneration》论文发表", "date_start": "2015", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕视网膜细胞治疗与视觉报告或讨论可复核的学术证据。", "summary": "该节点将视网膜细胞治疗与视觉的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2184" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 418 轮补录：视网膜细胞治疗与视觉；待本地复核。；日期补齐：Crossref 2015 (published-print, year, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-114", "title": "《Retinal regeneration and stem cell therapy in retinitis pigmentosa》论文发表", "date_start": "2012-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕视网膜细胞治疗与视觉报告或讨论可复核的学术证据。", "summary": "该节点将视网膜细胞治疗与视觉的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2185" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 418 轮补录：视网膜细胞治疗与视觉；待本地复核。；日期补齐：Crossref 2012-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-115", "title": "《Lens regeneration in children》论文发表", "date_start": "2018-04-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕晶状体再生与白内障修复报告或讨论可复核的学术证据。", "summary": "该节点将晶状体再生与白内障修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2186" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 419 轮补录：晶状体再生与白内障修复；待本地复核。；日期补齐：Crossref 2018-04-05 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-116", "title": "《An attempt at natural lens regeneration in congenital cataract surgery》论文发表", "date_start": "2017-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕晶状体再生与白内障修复报告或讨论可复核的学术证据。", "summary": "该节点将晶状体再生与白内障修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2187" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 419 轮补录：晶状体再生与白内障修复；待本地复核。；日期补齐：Crossref 2017-08 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-117", "title": "《Lens and Cataract》论文发表", "date_start": "1995-01-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕晶状体再生与白内障修复报告或讨论可复核的学术证据。", "summary": "该节点将晶状体再生与白内障修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2188" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 419 轮补录：晶状体再生与白内障修复；待本地复核。；日期补齐：Crossref 1995-01-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-118", "title": "《Lens and Cataract》论文发表", "date_start": "1993-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕晶状体再生与白内障修复报告或讨论可复核的学术证据。", "summary": "该节点将晶状体再生与白内障修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2189" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 419 轮补录：晶状体再生与白内障修复；待本地复核。；日期补齐：Crossref 1993-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-119", "title": "《Cataract surgery and lens implantation》论文发表", "date_start": "2019-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕晶状体再生与白内障修复报告或讨论可复核的学术证据。", "summary": "该节点将晶状体再生与白内障修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2190" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 419 轮补录：晶状体再生与白内障修复；待本地复核。；日期补齐：Crossref 2019-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-120", "title": "《Dry Eye Management: Targeting the Ocular Surface Microenvironment》论文发表", "date_start": "2017-06-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕干眼与眼表稳态维持报告或讨论可复核的学术证据。", "summary": "该节点将干眼与眼表稳态维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2191" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 420 轮补录：干眼与眼表稳态维持；待本地复核。；日期补齐：Crossref 2017-06-29 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-121", "title": "《Dry eye and ocular surface disease》论文发表", "date_start": "2014-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕干眼与眼表稳态维持报告或讨论可复核的学术证据。", "summary": "该节点将干眼与眼表稳态维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2192" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 420 轮补录：干眼与眼表稳态维持；待本地复核。；日期补齐：Crossref 2014-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-122", "title": "《Lacrimal Gland, Ocular Surface, and Dry Eye》论文发表", "date_start": "2016", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕干眼与眼表稳态维持报告或讨论可复核的学术证据。", "summary": "该节点将干眼与眼表稳态维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2193" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 420 轮补录：干眼与眼表稳态维持；待本地复核。；日期补齐：Crossref 2016 (published-print, year, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-123", "title": "《Ocular Surface Ion Transport and Dry Eye Disease》论文发表", "date_start": "2022-10-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕干眼与眼表稳态维持报告或讨论可复核的学术证据。", "summary": "该节点将干眼与眼表稳态维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2194" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 420 轮补录：干眼与眼表稳态维持；待本地复核。；日期补齐：Crossref 2022-10-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-124", "title": "《Ocular surface immune cell diversity in dry eye disease》论文发表", "date_start": "2023-04-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕干眼与眼表稳态维持报告或讨论可复核的学术证据。", "summary": "该节点将干眼与眼表稳态维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2195" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 420 轮补录：干眼与眼表稳态维持；待本地复核。；日期补齐：Crossref 2023-04-05 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-125", "title": "《SMELL AND TASTE COMPLAINTS》论文发表", "date_start": "2003-05-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕嗅觉味觉与化学感觉保存报告或讨论可复核的学术证据。", "summary": "该节点将嗅觉味觉与化学感觉保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2196" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 421 轮补录：嗅觉味觉与化学感觉保存；待本地复核。；日期补齐：Crossref 2003-05-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-126", "title": "《Aging inhibits olfactory recovery from traumatic olfactory system injury》论文发表", "date_start": "2025-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕嗅觉味觉与化学感觉保存报告或讨论可复核的学术证据。", "summary": "该节点将嗅觉味觉与化学感觉保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2197" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 421 轮补录：嗅觉味觉与化学感觉保存；待本地复核。；日期补齐：Crossref 2025-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-127", "title": "《Olfactory dysfunction in aging and neurodegenerative diseases》论文发表", "date_start": "2021-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕嗅觉味觉与化学感觉保存报告或讨论可复核的学术证据。", "summary": "该节点将嗅觉味觉与化学感觉保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2198" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 421 轮补录：嗅觉味觉与化学感觉保存；待本地复核。；日期补齐：Crossref 2021-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-128", "title": "《Taste, olfactory and trigeminal neophobia in rats with forebrain lesions》论文发表", "date_start": "2009-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕嗅觉味觉与化学感觉保存报告或讨论可复核的学术证据。", "summary": "该节点将嗅觉味觉与化学感觉保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2199" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 421 轮补录：嗅觉味觉与化学感觉保存；待本地复核。；日期补齐：Crossref 2009-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-129", "title": "《Aging and Olfactory Training: A Scoping Review》论文发表", "date_start": "2024-05-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕嗅觉味觉与化学感觉保存报告或讨论可复核的学术证据。", "summary": "该节点将嗅觉味觉与化学感觉保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2200" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 421 轮补录：嗅觉味觉与化学感觉保存；待本地复核。；日期补齐：Crossref 2024-05-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-130", "title": "《Swallow Screen Associated With Airway Protection and Dysphagia After Acute Stroke》论文发表", "date_start": "2019-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕吞咽安全与气道保护报告或讨论可复核的学术证据。", "summary": "该节点将吞咽安全与气道保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2201" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 422 轮补录：吞咽安全与气道保护；待本地复核。；日期补齐：Crossref 2019-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-131", "title": "《Training in Swallowing Prevents Aspiration Pneumonia in Stroke Patients with Dysphagia》论文发表", "date_start": "2006-05-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕吞咽安全与气道保护报告或讨论可复核的学术证据。", "summary": "该节点将吞咽安全与气道保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2202" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 422 轮补录：吞咽安全与气道保护；待本地复核。；日期补齐：Crossref 2006-05-01 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-132", "title": "《Aspiration and dysphagia screening in acute stroke – the Gugging Swallowing Screen revisited》论文发表", "date_start": "2017-02-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕吞咽安全与气道保护报告或讨论可复核的学术证据。", "summary": "该节点将吞咽安全与气道保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2203" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 422 轮补录：吞咽安全与气道保护；待本地复核。；日期补齐：Crossref 2017-02-03 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-133", "title": "《Dysphagia and Aspiration》论文发表", "date_start": "2015-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕吞咽安全与气道保护报告或讨论可复核的学术证据。", "summary": "该节点将吞咽安全与气道保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2204" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 422 轮补录：吞咽安全与气道保护；待本地复核。；日期补齐：Crossref 2015-08 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-134", "title": "《Prevalence and Severity of Dysphagia Using Videofluoroscopic Swallowing Study in Patients with Aspiration Pneumonia》论文发表", "date_start": "2021-01-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕吞咽安全与气道保护报告或讨论可复核的学术证据。", "summary": "该节点将吞咽安全与气道保护的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2205" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "感觉、运动与身体承载", "notes": "第 422 轮补录：吞咽安全与气道保护；待本地复核。；日期补齐：Crossref 2021-01-17 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-135", "title": "《Combining Aerobic Exercise and Speech Language Treatment for Aphasia Rehabilitation: A Case Study》论文发表", "date_start": "2018", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕言语与沟通康复报告或讨论可复核的学术证据。", "summary": "该节点将言语与沟通康复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2206" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、语言与沟通维护", "notes": "第 423 轮补录：言语与沟通康复；待本地复核。；日期补齐：Crossref 2018 (published-online, year, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-136", "title": "《Event-related potentials indicate bi-hemispherical changes in speech sound processing during aphasia rehabilitation》论文发表", "date_start": "2007", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕言语与沟通康复报告或讨论可复核的学术证据。", "summary": "该节点将言语与沟通康复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2207" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、语言与沟通维护", "notes": "第 423 轮补录：言语与沟通康复；待本地复核。；日期补齐：Crossref 2007 (published-print, year, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-137", "title": "《Applying the Rehabilitation Treatment Specification System to Functional Communication Treatment Approaches for Aphasia》论文发表", "date_start": "2022-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕言语与沟通康复报告或讨论可复核的学术证据。", "summary": "该节点将言语与沟通康复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2208" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、语言与沟通维护", "notes": "第 423 轮补录：言语与沟通康复；待本地复核。；日期补齐：Crossref 2022-03 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-138", "title": "《Computerised speech and language therapy in post-stroke aphasia》论文发表", "date_start": "2019-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕言语与沟通康复报告或讨论可复核的学术证据。", "summary": "该节点将言语与沟通康复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2209" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、语言与沟通维护", "notes": "第 423 轮补录：言语与沟通康复；待本地复核。；日期补齐：Crossref 2019-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-139", "title": "《Plastic Changes Following Imitation-Based Speech and Language Therapy for Aphasia》论文发表", "date_start": "2013-08-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕言语与沟通康复报告或讨论可复核的学术证据。", "summary": "该节点将言语与沟通康复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2210" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、语言与沟通维护", "notes": "第 423 轮补录：言语与沟通康复；待本地复核。；日期补齐：Crossref 2013-08-26 (published-online, day, v3)", "created_at": "2026-08-07T08:22:01Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-140", "title": "《Structural networks, language deficits, and aphasia recovery》论文发表", "date_start": "2018", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕失语症与语言功能恢复报告或讨论可复核的学术证据。", "summary": "该节点将失语症与语言功能恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2211" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、语言与沟通维护", "notes": "第 424 轮补录：失语症与语言功能恢复；待本地复核。；日期补齐：Crossref 2018 (published-online, year, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-141", "title": "《Predicting Language Recovery Outcomes in Individuals with Aphasia》论文发表", "date_start": "2016-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕失语症与语言功能恢复报告或讨论可复核的学术证据。", "summary": "该节点将失语症与语言功能恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2212" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、语言与沟通维护", "notes": "第 424 轮补录：失语症与语言功能恢复；待本地复核。；日期补齐：Crossref 2016-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-142", "title": "《Functional networks, language impairment and recovery after treatment in aphasia》论文发表", "date_start": "2018", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕失语症与语言功能恢复报告或讨论可复核的学术证据。", "summary": "该节点将失语症与语言功能恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2213" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、语言与沟通维护", "notes": "第 424 轮补录：失语症与语言功能恢复；待本地复核。；日期补齐：Crossref 2018 (published-online, year, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-143", "title": "《Neuroplasticity and Functional Recovery after Intensive Language Therapy in Chronic Post Stroke Aphasia: Which Factors Are Relevant?》论文发表", "date_start": "2017-06-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕失语症与语言功能恢复报告或讨论可复核的学术证据。", "summary": "该节点将失语症与语言功能恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2214" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、语言与沟通维护", "notes": "第 424 轮补录：失语症与语言功能恢复；待本地复核。；日期补齐：Crossref 2017-06-28 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-144", "title": "《Intensity of Aphasia Therapy, Impact on Recovery》论文发表", "date_start": "2003-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕失语症与语言功能恢复报告或讨论可复核的学术证据。", "summary": "该节点将失语症与语言功能恢复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2215" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、语言与沟通维护", "notes": "第 424 轮补录：失语症与语言功能恢复；待本地复核。；日期补齐：Crossref 2003-04 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-145", "title": "《Neuroplasticity and Motor Rehabilitation in Multiple Sclerosis》论文发表", "date_start": "2015-03-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕运动康复与神经重塑报告或讨论可复核的学术证据。", "summary": "该节点将运动康复与神经重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2216" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 425 轮补录：运动康复与神经重塑；待本地复核。；日期补齐：Crossref 2015-03-18 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-146", "title": "《Neuroplasticity in the context of motor rehabilitation after stroke》论文发表", "date_start": "2011-01-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕运动康复与神经重塑报告或讨论可复核的学术证据。", "summary": "该节点将运动康复与神经重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2217" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 425 轮补录：运动康复与神经重塑；待本地复核。；日期补齐：Crossref 2011-01-18 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-147", "title": "《Macrostructural Cerebellar Neuroplasticity Correlates With Motor Recovery After Stroke》论文发表", "date_start": "2023-10-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕运动康复与神经重塑报告或讨论可复核的学术证据。", "summary": "该节点将运动康复与神经重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2218" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 425 轮补录：运动康复与神经重塑；待本地复核。；日期补齐：Crossref 2023-10-26 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-148", "title": "《Virtual reality modulating dynamics of neuroplasticity: Innovations in neuro-motor rehabilitation》论文发表", "date_start": "2025-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕运动康复与神经重塑报告或讨论可复核的学术证据。", "summary": "该节点将运动康复与神经重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2219" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 425 轮补录：运动康复与神经重塑；待本地复核。；日期补齐：Crossref 2025-02 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-149", "title": "《Rehabilitation drives post-stroke motor recovery》论文发表", "date_start": "2025-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕运动康复与神经重塑报告或讨论可复核的学术证据。", "summary": "该节点将运动康复与神经重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2220" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 425 轮补录：运动康复与神经重塑；待本地复核。；日期补齐：Crossref 2025-05 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-150", "title": "《Falls Prevention for Older Adults》论文发表", "date_start": "2024-04-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕平衡与跌倒预防报告或讨论可复核的学术证据。", "summary": "该节点将平衡与跌倒预防的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2221" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 426 轮补录：平衡与跌倒预防；待本地复核。；日期补齐：Crossref 2024-04-23 (published-print, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-151", "title": "《Prevention of Falls in Older Adults》论文发表", "date_start": "2024-07-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕平衡与跌倒预防报告或讨论可复核的学术证据。", "summary": "该节点将平衡与跌倒预防的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2222" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 426 轮补录：平衡与跌倒预防；待本地复核。；日期补齐：Crossref 2024-07-02 (published-print, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-152", "title": "《Prevention of Falls in Community-Dwelling Older Adults》论文发表", "date_start": "2020-02-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕平衡与跌倒预防报告或讨论可复核的学术证据。", "summary": "该节点将平衡与跌倒预防的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2223" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 426 轮补录：平衡与跌倒预防；待本地复核。；日期补齐：Crossref 2020-02-20 (published-print, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-153", "title": "《PERCEIVED BALANCE PREDICTS FALLS IN COMMUNITY-DWELLING OLDER ADULTS》论文发表", "date_start": "2024-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕平衡与跌倒预防报告或讨论可复核的学术证据。", "summary": "该节点将平衡与跌倒预防的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2224" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 426 轮补录：平衡与跌倒预防；待本地复核。；日期补齐：Crossref 2024-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-154", "title": "《Older Adults’ Perceptions of Falls and Falls Prevention: An Interview-Based Study》论文发表", "date_start": "2020-12-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕平衡与跌倒预防报告或讨论可复核的学术证据。", "summary": "该节点将平衡与跌倒预防的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2225" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 426 轮补录：平衡与跌倒预防；待本地复核。；日期补齐：Crossref 2020-12-16 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-155", "title": "《A Novel Longitudinal Proteomic Aging Index Predicts Mortality, Multimorbidity, and Frailty in Older Adults》论文发表", "date_start": "2025-12-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰弱与多重慢病报告或讨论可复核的学术证据。", "summary": "该节点将衰弱与多重慢病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2226" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老综合征与长期功能维持", "notes": "第 427 轮补录：衰弱与多重慢病；待本地复核。；日期补齐：Crossref 2025-12-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-156", "title": "《ASSOCIATION OF FRAILTY WITH FIFTEEN-YEAR MORTALITY IN OLDER ADULTS WITHOUT MULTIMORBIDITY》论文发表", "date_start": "2018-11-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰弱与多重慢病报告或讨论可复核的学术证据。", "summary": "该节点将衰弱与多重慢病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2227" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老综合征与长期功能维持", "notes": "第 427 轮补录：衰弱与多重慢病；待本地复核。；日期补齐：Crossref 2018-11-11 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-157", "title": "《Beyond Unidirectional Decline: Identifying Nonlinear Frailty and Multimorbidity Trajectories in Older Adults》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰弱与多重慢病报告或讨论可复核的学术证据。", "summary": "该节点将衰弱与多重慢病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2228" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老综合征与长期功能维持", "notes": "第 427 轮补录：衰弱与多重慢病；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-158", "title": "《MULTIMORBIDITY PATTERNS PROVIDE ADDED PROGNOSTIC INFORMATION BEYOND FRAILTY STATUS IN OLDER ADULTS》论文发表", "date_start": "2017-06-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰弱与多重慢病报告或讨论可复核的学术证据。", "summary": "该节点将衰弱与多重慢病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2229" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老综合征与长期功能维持", "notes": "第 427 轮补录：衰弱与多重慢病；待本地复核。；日期补齐：Crossref 2017-06-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-159", "title": "《Frailty in Older Adults》论文发表", "date_start": "2006-11-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰弱与多重慢病报告或讨论可复核的学术证据。", "summary": "该节点将衰弱与多重慢病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2230" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "衰老综合征与长期功能维持", "notes": "第 427 轮补录：衰弱与多重慢病；待本地复核。；日期补齐：Crossref 2006-11-08 (published-print, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-160", "title": "《Dietary Patterns, Skeletal Muscle Health, and Sarcopenia in Older Adults》论文发表", "date_start": "2019-03-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肌少症与肌肉功能报告或讨论可复核的学术证据。", "summary": "该节点将肌少症与肌肉功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2231" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 428 轮补录：肌少症与肌肉功能；待本地复核。；日期补齐：Crossref 2019-03-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-161", "title": "《THE ROLE OF SKELETAL MUSCLE MYOSTATIN IN SARCOPENIA IN OLDER ADULTS》论文发表", "date_start": "2017-06-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肌少症与肌肉功能报告或讨论可复核的学术证据。", "summary": "该节点将肌少症与肌肉功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2232" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 428 轮补录：肌少症与肌肉功能；待本地复核。；日期补齐：Crossref 2017-06-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-162", "title": "《Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults》论文发表", "date_start": "2023-12-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肌少症与肌肉功能报告或讨论可复核的学术证据。", "summary": "该节点将肌少症与肌肉功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2233" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 428 轮补录：肌少症与肌肉功能；待本地复核。；日期补齐：Crossref 2023-12-28 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-163", "title": "《Sarcopenia and Cognitive Decline in Older Adults: Targeting the Muscle–Brain Axis》论文发表", "date_start": "2023-04-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肌少症与肌肉功能报告或讨论可复核的学术证据。", "summary": "该节点将肌少症与肌肉功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2234" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 428 轮补录：肌少症与肌肉功能；待本地复核。；日期补齐：Crossref 2023-04-12 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-164", "title": "《Traditional Chinese exercises on muscle strength, muscle mass, and physical function in older adults with sarcopenia: a systematic review and meta-analysis》论文发表", "date_start": "2026-08-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肌少症与肌肉功能报告或讨论可复核的学术证据。", "summary": "该节点将肌少症与肌肉功能的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2235" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 428 轮补录：肌少症与肌肉功能；待本地复核。；日期补齐：Crossref 2026-08-05 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-165", "title": "《Osteoporosis, fragility fracture, and periodontal disease》论文发表", "date_start": "2013-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕骨质疏松与骨骼韧性报告或讨论可复核的学术证据。", "summary": "该节点将骨质疏松与骨骼韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2236" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 429 轮补录：骨质疏松与骨骼韧性；待本地复核。；日期补齐：Crossref 2013-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-166", "title": "《Osteoporosis survey: GP management post fragility fracture》论文发表", "date_start": "2009-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕骨质疏松与骨骼韧性报告或讨论可复核的学术证据。", "summary": "该节点将骨质疏松与骨骼韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2237" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 429 轮补录：骨质疏松与骨骼韧性；待本地复核。；日期补齐：Crossref 2009-05 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-167", "title": "《Beyond bone density: toward an integrated bone– muscle–function framework for fragility fracture prevention》论文发表", "date_start": "2026-08-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕骨质疏松与骨骼韧性报告或讨论可复核的学术证据。", "summary": "该节点将骨质疏松与骨骼韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2238" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 429 轮补录：骨质疏松与骨骼韧性；待本地复核。；日期补齐：Crossref 2026-08-05 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-168", "title": "《OFELIA: Prevalence of Osteoporosis in Fragility Fracture Patients》论文发表", "date_start": "2018-09-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕骨质疏松与骨骼韧性报告或讨论可复核的学术证据。", "summary": "该节点将骨质疏松与骨骼韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2239" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 429 轮补录：骨质疏松与骨骼韧性；待本地复核。；日期补齐：Crossref 2018-09-17 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-169", "title": "《Osteoporosis Therapy: Bone Modeling during Growth and Aging》论文发表", "date_start": "2017-03-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕骨质疏松与骨骼韧性报告或讨论可复核的学术证据。", "summary": "该节点将骨质疏松与骨骼韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2240" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 429 轮补录：骨质疏松与骨骼韧性；待本地复核。；日期补齐：Crossref 2017-03-09 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-170", "title": "《Aging, articular cartilage chondrocyte senescence and osteoarthritis》论文发表", "date_start": "2002-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕软骨与关节保存报告或讨论可复核的学术证据。", "summary": "该节点将软骨与关节保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2241" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 430 轮补录：软骨与关节保存；待本地复核。；日期补齐：Crossref 2002-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-171", "title": "《Specific premature epigenetic aging of cartilage in osteoarthritis》论文发表", "date_start": "2016-09-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕软骨与关节保存报告或讨论可复核的学术证据。", "summary": "该节点将软骨与关节保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2242" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 430 轮补录：软骨与关节保存；待本地复核。；日期补齐：Crossref 2016-09-28 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-172", "title": "《Transthyretin and amyloid in cartilage aging and osteoarthritis》论文发表", "date_start": "2015-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕软骨与关节保存报告或讨论可复核的学术证据。", "summary": "该节点将软骨与关节保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2243" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 430 轮补录：软骨与关节保存；待本地复核。；日期补齐：Crossref 2015-04 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-173", "title": "《Targeting cartilage aging as osteoarthritis therapeutics by drug repurposing》论文发表", "date_start": "2017-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕软骨与关节保存报告或讨论可复核的学术证据。", "summary": "该节点将软骨与关节保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2244" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 430 轮补录：软骨与关节保存；待本地复核。；日期补齐：Crossref 2017-04 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-174", "title": "《Fibulin-3 in joint aging and osteoarthritis pathogenesis》论文发表", "date_start": "2014-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕软骨与关节保存报告或讨论可复核的学术证据。", "summary": "该节点将软骨与关节保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2245" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 430 轮补录：软骨与关节保存；待本地复核。；日期补齐：Crossref 2014-04 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-175", "title": "《Role of Biomaterials and Controlled Architecture on Tendon/Ligament Repair and Regeneration》论文发表", "date_start": "2019-12-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肌腱韧带修复报告或讨论可复核的学术证据。", "summary": "该节点将肌腱韧带修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2246" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 431 轮补录：肌腱韧带修复；待本地复核。；日期补齐：Crossref 2019-12-09 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-176", "title": "《Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration》论文发表", "date_start": "2019-09-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肌腱韧带修复报告或讨论可复核的学术证据。", "summary": "该节点将肌腱韧带修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2247" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 431 轮补录：肌腱韧带修复；待本地复核。；日期补齐：Crossref 2019-09-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-177", "title": "《Tendon Healing: Repair and Regeneration》论文发表", "date_start": "2012-08-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肌腱韧带修复报告或讨论可复核的学术证据。", "summary": "该节点将肌腱韧带修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2248" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 431 轮补录：肌腱韧带修复；待本地复核。；日期补齐：Crossref 2012-08-15 (published-print, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-178", "title": "《Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration》论文发表", "date_start": "2021-02-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肌腱韧带修复报告或讨论可复核的学术证据。", "summary": "该节点将肌腱韧带修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2249" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 431 轮补录：肌腱韧带修复；待本地复核。；日期补齐：Crossref 2021-02-12 (published-online, day, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-179", "title": "《Xenografts for tendon and ligament repair》论文发表", "date_start": "1994-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肌腱韧带修复报告或讨论可复核的学术证据。", "summary": "该节点将肌腱韧带修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2250" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 431 轮补录：肌腱韧带修复；待本地复核。；日期补齐：Crossref 1994-08 (published-print, month, v3)", "created_at": "2026-08-07T08:22:02Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-180", "title": "《Tooth Repair and Regeneration: Potential of Dental Stem Cells》论文发表", "date_start": "2021-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕牙髓与牙齿再生报告或讨论可复核的学术证据。", "summary": "该节点将牙髓与牙齿再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2251" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "口腔、感官与功能边界", "notes": "第 432 轮补录：牙髓与牙齿再生；待本地复核。；日期补齐：Crossref 2021-05 (published-print, month, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-181", "title": "《The Regenerative Potential of bFGF in Dental Pulp Repair and Regeneration》论文发表", "date_start": "2021-07-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕牙髓与牙齿再生报告或讨论可复核的学术证据。", "summary": "该节点将牙髓与牙齿再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2252" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "口腔、感官与功能边界", "notes": "第 432 轮补录：牙髓与牙齿再生；待本地复核。；日期补齐：Crossref 2021-07-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-182", "title": "《Stem cells and the dental pulp: potential roles in dentine regeneration and repair》论文发表", "date_start": "2007-02-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕牙髓与牙齿再生报告或讨论可复核的学术证据。", "summary": "该节点将牙髓与牙齿再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2253" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "口腔、感官与功能边界", "notes": "第 432 轮补录：牙髓与牙齿再生；待本地复核。；日期补齐：Crossref 2007-02-13 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-183", "title": "《A comparison between adipose tissue and dental pulp as sources of MSCs for tooth regeneration》论文发表", "date_start": "2011-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕牙髓与牙齿再生报告或讨论可复核的学术证据。", "summary": "该节点将牙髓与牙齿再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2254" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "口腔、感官与功能边界", "notes": "第 432 轮补录：牙髓与牙齿再生；待本地复核。；日期补齐：Crossref 2011-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-184", "title": "《Injectable Xenogeneic Dental Pulp Decellularized Extracellular Matrix Hydrogel Promotes Functional Dental Pulp Regeneration》论文发表", "date_start": "2023-12-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕牙髓与牙齿再生报告或讨论可复核的学术证据。", "summary": "该节点将牙髓与牙齿再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2255" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "口腔、感官与功能边界", "notes": "第 432 轮补录：牙髓与牙齿再生；待本地复核。；日期补齐：Crossref 2023-12-14 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-185", "title": "《Aging, longevity and health》论文发表", "date_start": "2011-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕口腔健康与长寿报告或讨论可复核的学术证据。", "summary": "该节点将口腔健康与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2256" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "口腔、感官与功能边界", "notes": "第 433 轮补录：口腔健康与长寿；待本地复核。；日期补齐：Crossref 2011-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-186", "title": "《Oral Health in Healthy Aging》论文发表", "date_start": "2017-12-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕口腔健康与长寿报告或讨论可复核的学术证据。", "summary": "该节点将口腔健康与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2257" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "口腔、感官与功能边界", "notes": "第 433 轮补录：口腔健康与长寿；待本地复核。；日期补齐：Crossref 2017-12-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-187", "title": "《Oral Microbiome, Oral Health and Systemic Health: A Multidirectional Link》论文发表", "date_start": "2022-01-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕口腔健康与长寿报告或讨论可复核的学术证据。", "summary": "该节点将口腔健康与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2258" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "口腔、感官与功能边界", "notes": "第 433 轮补录：口腔健康与长寿；待本地复核。；日期补齐：Crossref 2022-01-17 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-188", "title": "《Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health》论文发表", "date_start": "2022-10-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕口腔健康与长寿报告或讨论可复核的学术证据。", "summary": "该节点将口腔健康与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2259" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "口腔、感官与功能边界", "notes": "第 433 轮补录：口腔健康与长寿；待本地复核。；日期补齐：Crossref 2022-10-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-189", "title": "《Aging and Longevity》论文发表", "date_start": "2005-09-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕口腔健康与长寿报告或讨论可复核的学术证据。", "summary": "该节点将口腔健康与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2260" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "口腔、感官与功能边界", "notes": "第 433 轮补录：口腔健康与长寿；待本地复核。；日期补齐：Crossref 2005-09-02 (published-print, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-190", "title": "《Brain Aging and Gut–Brain Axis》论文发表", "date_start": "2019-02-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠脑轴与认知健康报告或讨论可复核的学术证据。", "summary": "该节点将肠脑轴与认知健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2261" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 434 轮补录：肠脑轴与认知健康；待本地复核。；日期补齐：Crossref 2019-02-18 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-191", "title": "《Is aging preprogrammed? Observations from the brain/gut axis》论文发表", "date_start": "1991-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠脑轴与认知健康报告或讨论可复核的学术证据。", "summary": "该节点将肠脑轴与认知健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2262" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 434 轮补录：肠脑轴与认知健康；待本地复核。；日期补齐：Crossref 1991-12 (published-print, month, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-192", "title": "《The Impact of Microbiota-Gut-Brain Axis on Diabetic Cognition Impairment》论文发表", "date_start": "2017-04-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠脑轴与认知健康报告或讨论可复核的学术证据。", "summary": "该节点将肠脑轴与认知健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2263" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 434 轮补录：肠脑轴与认知健康；待本地复核。；日期补齐：Crossref 2017-04-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-193", "title": "《Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome》论文发表", "date_start": "2022-04-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠脑轴与认知健康报告或讨论可复核的学术证据。", "summary": "该节点将肠脑轴与认知健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2264" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 434 轮补录：肠脑轴与认知健康；待本地复核。；日期补齐：Crossref 2022-04-15 (published-print, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-194", "title": "《The brain-gut-muscle axis: a mechanism for exercise-mediated protection in brain aging》论文发表", "date_start": "2026-03-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠脑轴与认知健康报告或讨论可复核的学术证据。", "summary": "该节点将肠脑轴与认知健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2265" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 434 轮补录：肠脑轴与认知健康；待本地复核。；日期补齐：Crossref 2026-03-04 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-195", "title": "《Intestinal barrier permeability: the influence of gut microbiota, nutrition, and exercise》论文发表", "date_start": "2024-07-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠道屏障与通透性报告或讨论可复核的学术证据。", "summary": "该节点将肠道屏障与通透性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2266" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 435 轮补录：肠道屏障与通透性；待本地复核。；日期补齐：Crossref 2024-07-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-196", "title": "《Intestinal Barrier and Permeability in Health, Obesity and NAFLD》论文发表", "date_start": "2021-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠道屏障与通透性报告或讨论可复核的学术证据。", "summary": "该节点将肠道屏障与通透性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2267" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 435 轮补录：肠道屏障与通透性；待本地复核。；日期补齐：Crossref 2021-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-197", "title": "《The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability》论文发表", "date_start": "2020-08-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠道屏障与通透性报告或讨论可复核的学术证据。", "summary": "该节点将肠道屏障与通透性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2268" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 435 轮补录：肠道屏障与通透性；待本地复核。；日期补齐：Crossref 2020-08-17 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-198", "title": "《Intestinal Barrier Permeability in Allergic Diseases》论文发表", "date_start": "2022-04-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠道屏障与通透性报告或讨论可复核的学术证据。", "summary": "该节点将肠道屏障与通透性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2269" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 435 轮补录：肠道屏障与通透性；待本地复核。；日期补齐：Crossref 2022-04-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-199", "title": "《Gut Microbiota and Intestinal Trans-Epithelial Permeability》论文发表", "date_start": "2020-09-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠道屏障与通透性报告或讨论可复核的学术证据。", "summary": "该节点将肠道屏障与通透性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2270" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 435 轮补录：肠道屏障与通透性；待本地复核。；日期补齐：Crossref 2020-09-03 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-200", "title": "《THE GUT MICROBIOME AND AGING》论文发表", "date_start": "2019-11-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠道微生物代谢与衰老报告或讨论可复核的学术证据。", "summary": "该节点将肠道微生物代谢与衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2271" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 436 轮补录：肠道微生物代谢与衰老；待本地复核。；日期补齐：Crossref 2019-11-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-201", "title": "《Gut microbiome and health: mechanistic insights》论文发表", "date_start": "2022-02-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠道微生物代谢与衰老报告或讨论可复核的学术证据。", "summary": "该节点将肠道微生物代谢与衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2272" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 436 轮补录：肠道微生物代谢与衰老；待本地复核。；日期补齐：Crossref 2022-02-01 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-202", "title": "《Gut Microbiome and Microbiome-Derived Metabolites in Patients with End-Stage Kidney Disease》论文发表", "date_start": "2023-07-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠道微生物代谢与衰老报告或讨论可复核的学术证据。", "summary": "该节点将肠道微生物代谢与衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2273" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 436 轮补录：肠道微生物代谢与衰老；待本地复核。；日期补齐：Crossref 2023-07-14 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-203", "title": "《The Gut Microbiome, Aging, and Longevity: A Systematic Review》论文发表", "date_start": "2020-12-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠道微生物代谢与衰老报告或讨论可复核的学术证据。", "summary": "该节点将肠道微生物代谢与衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2274" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 436 轮补录：肠道微生物代谢与衰老；待本地复核。；日期补齐：Crossref 2020-12-07 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-204", "title": "《STRESS, STEM CELLS, AND THE GUT MICROBIOME—IMPLICATIONS FOR AGING》论文发表", "date_start": "2023-12-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肠道微生物代谢与衰老报告或讨论可复核的学术证据。", "summary": "该节点将肠道微生物代谢与衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2275" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 436 轮补录：肠道微生物代谢与衰老；待本地复核。；日期补齐：Crossref 2023-12-21 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-205", "title": "《Short-chain fatty acids in fetal development and metabolism》论文发表", "date_start": "2025-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕短链脂肪酸与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将短链脂肪酸与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2276" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 437 轮补录：短链脂肪酸与健康寿命；待本地复核。；日期补齐：Crossref 2025-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-206", "title": "《Short-chain fatty acids》论文发表", "date_start": "2026-07-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕短链脂肪酸与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将短链脂肪酸与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2277" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 437 轮补录：短链脂肪酸与健康寿命；待本地复核。；日期补齐：Crossref 2026-07-29 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-207", "title": "《Short-Chain Fatty Acids, Maternal Microbiota and Metabolism in Pregnancy》论文发表", "date_start": "2021-04-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕短链脂肪酸与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将短链脂肪酸与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2278" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 437 轮补录：短链脂肪酸与健康寿命；待本地复核。；日期补齐：Crossref 2021-04-09 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-208", "title": "《Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids》论文发表", "date_start": "2021-10-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕短链脂肪酸与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将短链脂肪酸与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2279" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 437 轮补录：短链脂肪酸与健康寿命；待本地复核。；日期补齐：Crossref 2021-10-19 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-209", "title": "《Effect of lactulose on the metabolism of short-chain fatty acids》论文发表", "date_start": "1990-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕短链脂肪酸与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将短链脂肪酸与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2280" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、微生物与代谢维护", "notes": "第 437 轮补录：短链脂肪酸与健康寿命；待本地复核。；日期补齐：Crossref 1990-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-210", "title": "《SnapShot: Sirtuins, NAD, and Aging》论文发表", "date_start": "2014-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕NAD+代谢与去乙酰化酶报告或讨论可复核的学术证据。", "summary": "该节点将NAD+代谢与去乙酰化酶的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2281" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 438 轮补录：NAD+代谢与去乙酰化酶；待本地复核。；日期补齐：Crossref 2014-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-211", "title": "《NAD+ and sirtuins in aging and disease》论文发表", "date_start": "2014-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕NAD+代谢与去乙酰化酶报告或讨论可复核的学术证据。", "summary": "该节点将NAD+代谢与去乙酰化酶的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2282" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 438 轮补录：NAD+代谢与去乙酰化酶；待本地复核。；日期补齐：Crossref 2014-08 (published-print, month, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-212", "title": "《The Many Faces of Sirtuins: Coupling of NAD metabolism, sirtuins and lifespan》论文发表", "date_start": "2014-01-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕NAD+代谢与去乙酰化酶报告或讨论可复核的学术证据。", "summary": "该节点将NAD+代谢与去乙酰化酶的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2283" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 438 轮补录：NAD+代谢与去乙酰化酶；待本地复核。；日期补齐：Crossref 2014-01-07 (published-online, day, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-213", "title": "《NAD metabolism: Implications in aging and longevity》论文发表", "date_start": "2018-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕NAD+代谢与去乙酰化酶报告或讨论可复核的学术证据。", "summary": "该节点将NAD+代谢与去乙酰化酶的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2284" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 438 轮补录：NAD+代谢与去乙酰化酶；待本地复核。；日期补齐：Crossref 2018-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-214", "title": "《Regulation of NAD+ metabolism in aging and disease》论文发表", "date_start": "2022-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕NAD+代谢与去乙酰化酶报告或讨论可复核的学术证据。", "summary": "该节点将NAD+代谢与去乙酰化酶的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2285" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 438 轮补录：NAD+代谢与去乙酰化酶；待本地复核。；日期补齐：Crossref 2022-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:03Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-215", "title": "《Metabolic pathways and therapeutics to promote resilience, rehabilitation and delayed aging》论文发表", "date_start": "2021-04-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕AMPK与代谢韧性报告或讨论可复核的学术证据。", "summary": "该节点将AMPK与代谢韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2286" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 439 轮补录：AMPK与代谢韧性；待本地复核。；日期补齐：Crossref 2021-04-28 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-216", "title": "《228-LB: Metformin Alleviates Aging-Associated Metabolic Disorders through Intestinal AMPK-Mediated Gut Microbiome Alteration》论文发表", "date_start": "2023-06-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕AMPK与代谢韧性报告或讨论可复核的学术证据。", "summary": "该节点将AMPK与代谢韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2287" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 439 轮补录：AMPK与代谢韧性；待本地复核。；日期补齐：Crossref 2023-06-20 (published-print, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-217", "title": "《Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder》论文发表", "date_start": "2018-09-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕AMPK与代谢韧性报告或讨论可复核的学术证据。", "summary": "该节点将AMPK与代谢韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2288" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 439 轮补录：AMPK与代谢韧性；待本地复核。；日期补齐：Crossref 2018-09-18 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-218", "title": "《SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production》论文发表", "date_start": "2024-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕AMPK与代谢韧性报告或讨论可复核的学术证据。", "summary": "该节点将AMPK与代谢韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2289" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 439 轮补录：AMPK与代谢韧性；待本地复核。；日期补齐：Crossref 2024-08 (published-print, month, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-219", "title": "《AMPK at the Nexus of Energetics and Aging》论文发表", "date_start": "2014-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕AMPK与代谢韧性报告或讨论可复核的学术证据。", "summary": "该节点将AMPK与代谢韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2290" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 439 轮补录：AMPK与代谢韧性；待本地复核。；日期补齐：Crossref 2014-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-220", "title": "《mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review》论文发表", "date_start": "2017-12-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕mTOR通路与寿命调控报告或讨论可复核的学术证据。", "summary": "该节点将mTOR通路与寿命调控的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2291" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 440 轮补录：mTOR通路与寿命调控；待本地复核。；日期补齐：Crossref 2017-12-01 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-221", "title": "《The Crucial Roles of Phospholipids in Aging and Lifespan Regulation》论文发表", "date_start": "2021-11-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕mTOR通路与寿命调控报告或讨论可复核的学术证据。", "summary": "该节点将mTOR通路与寿命调控的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2292" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 440 轮补录：mTOR通路与寿命调控；待本地复核。；日期补齐：Crossref 2021-11-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-222", "title": "《BMAL1-dependent regulation of the mTOR signaling pathway delays aging》论文发表", "date_start": "2014-01-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕mTOR通路与寿命调控报告或讨论可复核的学术证据。", "summary": "该节点将mTOR通路与寿命调控的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2293" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 440 轮补录：mTOR通路与寿命调控；待本地复核。；日期补齐：Crossref 2014-01-29 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-223", "title": "《mTOR links nutrients, inflammaging and lifespan》论文发表", "date_start": "2024-07-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕mTOR通路与寿命调控报告或讨论可复核的学术证据。", "summary": "该节点将mTOR通路与寿命调控的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2294" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 440 轮补录：mTOR通路与寿命调控；待本地复核。；日期补齐：Crossref 2024-07-26 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-224", "title": "《The role of lipid metabolism in aging, lifespan regulation, and age‐related disease》论文发表", "date_start": "2019-09-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕mTOR通路与寿命调控报告或讨论可复核的学术证据。", "summary": "该节点将mTOR通路与寿命调控的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2295" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 440 轮补录：mTOR通路与寿命调控；待本地复核。；日期补齐：Crossref 2019-09-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-225", "title": "《Senolytics combat COVID-19 in aging》论文发表", "date_start": "2023-07-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰老细胞清除与衰老抑制药物报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除与衰老抑制药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2296" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、清除与组织年轻化", "notes": "第 441 轮补录：衰老细胞清除与衰老抑制药物；待本地复核。；日期补齐：Crossref 2023-07-06 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-226", "title": "《Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids》论文发表", "date_start": "2025-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰老细胞清除与衰老抑制药物报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除与衰老抑制药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2297" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、清除与组织年轻化", "notes": "第 441 轮补录：衰老细胞清除与衰老抑制药物；待本地复核。；日期补齐：Crossref 2025-02 (published-print, month, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-227", "title": "《Senolytics under scrutiny in the quest to slow aging》论文发表", "date_start": "2025-07-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰老细胞清除与衰老抑制药物报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除与衰老抑制药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2298" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、清除与组织年轻化", "notes": "第 441 轮补录：衰老细胞清除与衰老抑制药物；待本地复核。；日期补齐：Crossref 2025-07-03 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-228", "title": "《Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging》论文发表", "date_start": "2020-01-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰老细胞清除与衰老抑制药物报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除与衰老抑制药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2299" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、清除与组织年轻化", "notes": "第 441 轮补录：衰老细胞清除与衰老抑制药物；待本地复核。；日期补齐：Crossref 2020-01-22 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-229", "title": "《Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging – from theory to practice》论文发表", "date_start": "2022-09-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰老细胞清除与衰老抑制药物报告或讨论可复核的学术证据。", "summary": "该节点将衰老细胞清除与衰老抑制药物的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2300" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、清除与组织年轻化", "notes": "第 441 轮补录：衰老细胞清除与衰老抑制药物；待本地复核。；日期补齐：Crossref 2022-09-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-230", "title": "《Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase》论文发表", "date_start": "2019-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰老相关分泌表型调控报告或讨论可复核的学术证据。", "summary": "该节点将衰老相关分泌表型调控的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2301" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、清除与组织年轻化", "notes": "第 442 轮补录：衰老相关分泌表型调控；待本地复核。；日期补齐：Crossref 2019-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-231", "title": "《A Senescence Associated Secretory Phenotype (SASP) in Indolent Systemic Mastocytosis Compared to Healthy Controls》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰老相关分泌表型调控报告或讨论可复核的学术证据。", "summary": "该节点将衰老相关分泌表型调控的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2302" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、清除与组织年轻化", "notes": "第 442 轮补录：衰老相关分泌表型调控；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-232", "title": "《Abstract 11559: Prognostic Significance of Senescence-Associated Secretory Phenotype (SASP) Biomarkers in Heart Failure (HF)》论文发表", "date_start": "2022-11-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰老相关分泌表型调控报告或讨论可复核的学术证据。", "summary": "该节点将衰老相关分泌表型调控的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2303" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、清除与组织年轻化", "notes": "第 442 轮补录：衰老相关分泌表型调控；待本地复核。；日期补齐：Crossref 2022-11-08 (published-print, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-233", "title": "《Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human》论文发表", "date_start": "2024-02-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰老相关分泌表型调控报告或讨论可复核的学术证据。", "summary": "该节点将衰老相关分泌表型调控的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2304" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、清除与组织年轻化", "notes": "第 442 轮补录：衰老相关分泌表型调控；待本地复核。；日期补齐：Crossref 2024-02-12 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-234", "title": "《The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification》论文发表", "date_start": "2020-06-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕衰老相关分泌表型调控报告或讨论可复核的学术证据。", "summary": "该节点将衰老相关分泌表型调控的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2305" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞衰老、清除与组织年轻化", "notes": "第 442 轮补录：衰老相关分泌表型调控；待本地复核。；日期补齐：Crossref 2020-06-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-235", "title": "《Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging》论文发表", "date_start": "2017-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕蛋白稳态网络与应激响应报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态网络与应激响应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2306" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与质量控制", "notes": "第 443 轮补录：蛋白稳态网络与应激响应；待本地复核。；日期补齐：Crossref 2017-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-236", "title": "《Proteostasis and aging》论文发表", "date_start": "2015-12-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕蛋白稳态网络与应激响应报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态网络与应激响应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2307" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与质量控制", "notes": "第 443 轮补录：蛋白稳态网络与应激响应；待本地复核。；日期补齐：Crossref 2015-12-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-237", "title": "《Mastering organismal aging through the endoplasmic reticulum proteostasis network》论文发表", "date_start": "2020-10-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕蛋白稳态网络与应激响应报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态网络与应激响应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2308" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与质量控制", "notes": "第 443 轮补录：蛋白稳态网络与应激响应；待本地复核。；日期补齐：Crossref 2020-10-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-238", "title": "《Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging》论文发表", "date_start": "2021-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕蛋白稳态网络与应激响应报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态网络与应激响应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2309" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与质量控制", "notes": "第 443 轮补录：蛋白稳态网络与应激响应；待本地复核。；日期补齐：Crossref 2021-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-239", "title": "《Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging》论文发表", "date_start": "2023-07-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕蛋白稳态网络与应激响应报告或讨论可复核的学术证据。", "summary": "该节点将蛋白稳态网络与应激响应的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2310" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与质量控制", "notes": "第 443 轮补录：蛋白稳态网络与应激响应；待本地复核。；日期补齐：Crossref 2023-07-04 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-240", "title": "《Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy》论文发表", "date_start": "2014-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕自噬与溶酶体清除报告或讨论可复核的学术证据。", "summary": "该节点将自噬与溶酶体清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2311" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与质量控制", "notes": "第 444 轮补录：自噬与溶酶体清除；待本地复核。；日期补齐：Crossref 2014-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-241", "title": "《Aging: Central role for autophagy and the lysosomal degradative system》论文发表", "date_start": "2009-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕自噬与溶酶体清除报告或讨论可复核的学术证据。", "summary": "该节点将自噬与溶酶体清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2312" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与质量控制", "notes": "第 444 轮补录：自噬与溶酶体清除；待本地复核。；日期补齐：Crossref 2009-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-242", "title": "《Asparagine prevents intestinal stem cell aging via the autophagy‐lysosomal pathway》论文发表", "date_start": "2024-11-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕自噬与溶酶体清除报告或讨论可复核的学术证据。", "summary": "该节点将自噬与溶酶体清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2313" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与质量控制", "notes": "第 444 轮补录：自噬与溶酶体清除；待本地复核。；日期补齐：Crossref 2024-11-25 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-243", "title": "《Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function》论文发表", "date_start": "2020-05-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕自噬与溶酶体清除报告或讨论可复核的学术证据。", "summary": "该节点将自噬与溶酶体清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2314" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与质量控制", "notes": "第 444 轮补录：自噬与溶酶体清除；待本地复核。；日期补齐：Crossref 2020-05-05 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-244", "title": "《“LRRK2: Autophagy and Lysosomal Activity”》论文发表", "date_start": "2020-05-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕自噬与溶酶体清除报告或讨论可复核的学术证据。", "summary": "该节点将自噬与溶酶体清除的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2315" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "蛋白稳态、自噬与质量控制", "notes": "第 444 轮补录：自噬与溶酶体清除；待本地复核。；日期补齐：Crossref 2020-05-25 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-245", "title": "《Mitophagy: At the heart of mitochondrial quality control in cardiac aging and frailty》论文发表", "date_start": "2021-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕线粒体自噬与质量控制报告或讨论可复核的学术证据。", "summary": "该节点将线粒体自噬与质量控制的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2316" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 445 轮补录：线粒体自噬与质量控制；待本地复核。；日期补齐：Crossref 2021-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-246", "title": "《Renal aging and mitochondrial quality control》论文发表", "date_start": "2024-02-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕线粒体自噬与质量控制报告或讨论可复核的学术证据。", "summary": "该节点将线粒体自噬与质量控制的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2317" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 445 轮补录：线粒体自噬与质量控制；待本地复核。；日期补齐：Crossref 2024-02-13 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-247", "title": "《The role of mitochondrial quality surveillance in skin aging: Focus on mitochondrial dynamics, biogenesis and mitophagy》论文发表", "date_start": "2023-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕线粒体自噬与质量控制报告或讨论可复核的学术证据。", "summary": "该节点将线粒体自噬与质量控制的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2318" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 445 轮补录：线粒体自噬与质量控制；待本地复核。；日期补齐：Crossref 2023-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-248", "title": "《Inflammation and mitophagy are mitochondrial checkpoints to aging》论文发表", "date_start": "2024-04-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕线粒体自噬与质量控制报告或讨论可复核的学术证据。", "summary": "该节点将线粒体自噬与质量控制的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2319" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 445 轮补录：线粒体自噬与质量控制；待本地复核。；日期补齐：Crossref 2024-04-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-249", "title": "《SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy》论文发表", "date_start": "2017-10-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕线粒体自噬与质量控制报告或讨论可复核的学术证据。", "summary": "该节点将线粒体自噬与质量控制的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2320" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 445 轮补录：线粒体自噬与质量控制；待本地复核。；日期补齐：Crossref 2017-10-29 (published-online, day, v3)", "created_at": "2026-08-07T08:22:04Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-250", "title": "《Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases》论文发表", "date_start": "2013-12-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕线粒体动力学与融合分裂报告或讨论可复核的学术证据。", "summary": "该节点将线粒体动力学与融合分裂的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2321" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 446 轮补录：线粒体动力学与融合分裂；待本地复核。；日期补齐：Crossref 2013-12-05 (published-print, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-251", "title": "《Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity》论文发表", "date_start": "2016-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕线粒体动力学与融合分裂报告或讨论可复核的学术证据。", "summary": "该节点将线粒体动力学与融合分裂的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2322" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 446 轮补录：线粒体动力学与融合分裂；待本地复核。；日期补齐：Crossref 2016-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-252", "title": "《Mitochondrial Fission, Fusion, and Stress》论文发表", "date_start": "2012-08-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕线粒体动力学与融合分裂报告或讨论可复核的学术证据。", "summary": "该节点将线粒体动力学与融合分裂的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2323" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 446 轮补录：线粒体动力学与融合分裂；待本地复核。；日期补齐：Crossref 2012-08-31 (published-print, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-253", "title": "《Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss》论文发表", "date_start": "2020-07-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕线粒体动力学与融合分裂报告或讨论可复核的学术证据。", "summary": "该节点将线粒体动力学与融合分裂的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2324" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 446 轮补录：线粒体动力学与融合分裂；待本地复核。；日期补齐：Crossref 2020-07-14 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-254", "title": "《Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells》论文发表", "date_start": "2020-10-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕线粒体动力学与融合分裂报告或讨论可复核的学术证据。", "summary": "该节点将线粒体动力学与融合分裂的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2325" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 446 轮补录：线粒体动力学与融合分裂；待本地复核。；日期补齐：Crossref 2020-10-15 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-255", "title": "《Extracellular Redox State: Refining the Definition of Oxidative Stress in Aging》论文发表", "date_start": "2006-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕氧化应激与氧化还原信号报告或讨论可复核的学术证据。", "summary": "该节点将氧化应激与氧化还原信号的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2326" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 447 轮补录：氧化应激与氧化还原信号；待本地复核。；日期补齐：Crossref 2006-06 (published-online, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-256", "title": "《Oxidative stress and aberrant signaling in aging and cognitive decline》论文发表", "date_start": "2007-03-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕氧化应激与氧化还原信号报告或讨论可复核的学术证据。", "summary": "该节点将氧化应激与氧化还原信号的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2327" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 447 轮补录：氧化应激与氧化还原信号；待本地复核。；日期补齐：Crossref 2007-03-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-257", "title": "《Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension》论文发表", "date_start": "2004-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕氧化应激与氧化还原信号报告或讨论可复核的学术证据。", "summary": "该节点将氧化应激与氧化还原信号的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2328" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 447 轮补录：氧化应激与氧化还原信号；待本地复核。；日期补齐：Crossref 2004-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-258", "title": "《Oxidative stress and aging》论文发表", "date_start": "1996-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕氧化应激与氧化还原信号报告或讨论可复核的学术证据。", "summary": "该节点将氧化应激与氧化还原信号的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2329" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 447 轮补录：氧化应激与氧化还原信号；待本地复核。；日期补齐：Crossref 1996-05 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-259", "title": "《Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes》论文发表", "date_start": "2007-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕氧化应激与氧化还原信号报告或讨论可复核的学术证据。", "summary": "该节点将氧化应激与氧化还原信号的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2330" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "线粒体、能量与氧化应激", "notes": "第 447 轮补录：氧化应激与氧化还原信号；待本地复核。；日期补齐：Crossref 2007-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-260", "title": "《Lipid Metabolism at Membrane Contacts: Dynamics and Functions Beyond Lipid Homeostasis》论文发表", "date_start": "2020-12-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脂质代谢与膜稳态报告或讨论可复核的学术证据。", "summary": "该节点将脂质代谢与膜稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2331" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 448 轮补录：脂质代谢与膜稳态；待本地复核。；日期补齐：Crossref 2020-12-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-261", "title": "《Membrane lipid homeostasis in bacteria》论文发表", "date_start": "2008-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脂质代谢与膜稳态报告或讨论可复核的学术证据。", "summary": "该节点将脂质代谢与膜稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2332" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 448 轮补录：脂质代谢与膜稳态；待本地复核。；日期补齐：Crossref 2008-03 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-262", "title": "《Lipid metabolism in homeostasis and disease》论文发表", "date_start": "2026-02-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脂质代谢与膜稳态报告或讨论可复核的学术证据。", "summary": "该节点将脂质代谢与膜稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2333" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 448 轮补录：脂质代谢与膜稳态；待本地复核。；日期补齐：Crossref 2026-02-16 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-263", "title": "《Lipid-anchored proteasomes control membrane protein homeostasis》论文发表", "date_start": "2023-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脂质代谢与膜稳态报告或讨论可复核的学术证据。", "summary": "该节点将脂质代谢与膜稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2334" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 448 轮补录：脂质代谢与膜稳态；待本地复核。；日期补齐：Crossref 2023-12 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-264", "title": "《Lipid landscapes and pipelines in membrane homeostasis》论文发表", "date_start": "2014-06-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脂质代谢与膜稳态报告或讨论可复核的学术证据。", "summary": "该节点将脂质代谢与膜稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2335" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 448 轮补录：脂质代谢与膜稳态；待本地复核。；日期补齐：Crossref 2014-06-04 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-265", "title": "《Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction》论文发表", "date_start": "2020-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胆固醇与心血管老化报告或讨论可复核的学术证据。", "summary": "该节点将胆固醇与心血管老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2336" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 449 轮补录：胆固醇与心血管老化；待本地复核。；日期补齐：Crossref 2020-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-266", "title": "《Remnant Cholesterol and Triglyceride-Rich Lipoproteins in Atherosclerosis Progression and Cardiovascular Disease》论文发表", "date_start": "2016-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胆固醇与心血管老化报告或讨论可复核的学术证据。", "summary": "该节点将胆固醇与心血管老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2337" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 449 轮补录：胆固醇与心血管老化；待本地复核。；日期补齐：Crossref 2016-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-267", "title": "《CARDIOVASCULAR HEALTH AND SUCCESSFUL AGING: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS》论文发表", "date_start": "2019-11-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胆固醇与心血管老化报告或讨论可复核的学术证据。", "summary": "该节点将胆固醇与心血管老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2338" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 449 轮补录：胆固醇与心血管老化；待本地复核。；日期补齐：Crossref 2019-11-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-268", "title": "《Subclinical Cardiovascular Disease and Atherosclerosis Are Not Inevitable Consequences of Aging》论文发表", "date_start": "2015-04-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胆固醇与心血管老化报告或讨论可复核的学术证据。", "summary": "该节点将胆固醇与心血管老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2339" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 449 轮补录：胆固醇与心血管老化；待本地复核。；日期补齐：Crossref 2015-04-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-269", "title": "《P3456Total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol in atherosclerosis cardiovascular disease and cancer in Chinese male》论文发表", "date_start": "2017-08-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胆固醇与心血管老化报告或讨论可复核的学术证据。", "summary": "该节点将胆固醇与心血管老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2340" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 449 轮补录：胆固醇与心血管老化；待本地复核。；日期补齐：Crossref 2017-08-29 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-270", "title": "《NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension》论文发表", "date_start": "2024-05-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕血压控制与血管老化报告或讨论可复核的学术证据。", "summary": "该节点将血压控制与血管老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2341" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 450 轮补录：血压控制与血管老化；待本地复核。；日期补齐：Crossref 2024-05-24 (published-print, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-271", "title": "《Spironolactone and Hydrochlorothiazide Decrease Vascular Stiffness and Blood Pressure in Geriatric Hypertension》论文发表", "date_start": "2010-07-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕血压控制与血管老化报告或讨论可复核的学术证据。", "summary": "该节点将血压控制与血管老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2342" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 450 轮补录：血压控制与血管老化；待本地复核。；日期补齐：Crossref 2010-07-02 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-272", "title": "《Dietary Approaches to Stop Hypertension Dietary Intervention Improves Blood Pressure and Vascular Health in Youth With Elevated Blood Pressure》论文发表", "date_start": "2021-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕血压控制与血管老化报告或讨论可复核的学术证据。", "summary": "该节点将血压控制与血管老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2343" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 450 轮补录：血压控制与血管老化；待本地复核。；日期补齐：Crossref 2021-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-273", "title": "《Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans》论文发表", "date_start": "2021-03-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕血压控制与血管老化报告或讨论可复核的学术证据。", "summary": "该节点将血压控制与血管老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2344" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 450 轮补录：血压控制与血管老化；待本地复核。；日期补齐：Crossref 2021-03-16 (published-print, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-274", "title": "《Hypertension and Ambulatory Blood Pressure》论文发表", "date_start": "1994-09-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕血压控制与血管老化报告或讨论可复核的学术证据。", "summary": "该节点将血压控制与血管老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2345" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 450 轮补录：血压控制与血管老化；待本地复核。；日期补齐：Crossref 1994-09-02 (published-print, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-275", "title": "《Arterial Stiffness and Pulse Wave Velocity: Problems with Terminology》论文发表", "date_start": "2004-01-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕动脉硬化与脉搏波速报告或讨论可复核的学术证据。", "summary": "该节点将动脉硬化与脉搏波速的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2346" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 451 轮补录：动脉硬化与脉搏波速；待本地复核。；日期补齐：Crossref 2004-01-20 (published-print, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-276", "title": "《Chest Pulse-Wave Velocity: A Novel Approach to Assess Arterial Stiffness》论文发表", "date_start": "2011-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕动脉硬化与脉搏波速报告或讨论可复核的学术证据。", "summary": "该节点将动脉硬化与脉搏波速的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2347" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 451 轮补录：动脉硬化与脉搏波速；待本地复核。；日期补齐：Crossref 2011-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-277", "title": "《Heart-Ankle Pulse Wave Velocity Is Superior to Brachial-Ankle Pulse Wave Velocity in Detecting Aldosterone-Induced Arterial Stiffness》论文发表", "date_start": "2021-09-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕动脉硬化与脉搏波速报告或讨论可复核的学术证据。", "summary": "该节点将动脉硬化与脉搏波速的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2348" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 451 轮补录：动脉硬化与脉搏波速；待本地复核。；日期补齐：Crossref 2021-09-22 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-278", "title": "《HEART-FEMORAL PULSE WAVE VELOCITY IS A STRONGER MARKER OF ARTERIAL AGING THAN CAROTID-FEMORAL PULSE WAVE VELOCITY》论文发表", "date_start": "2017-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕动脉硬化与脉搏波速报告或讨论可复核的学术证据。", "summary": "该节点将动脉硬化与脉搏波速的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2349" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 451 轮补录：动脉硬化与脉搏波速；待本地复核。；日期补齐：Crossref 2017-03 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-279", "title": "《SP304NON INVASIVE ASSESSMENT OF ARTERIAL STIFFNESS USING PULSE WAVE VELOCITY IN NEPHROLOGY OUTPATIENTS》论文发表", "date_start": "2016-05-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕动脉硬化与脉搏波速报告或讨论可复核的学术证据。", "summary": "该节点将动脉硬化与脉搏波速的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2350" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 451 轮补录：动脉硬化与脉搏波速；待本地复核。；日期补齐：Crossref 2016-05-14 (published-online, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-280", "title": "《Endothelial S100A1 Modulates Vascular Function via Nitric Oxide》论文发表", "date_start": "2008-04-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕内皮功能与一氧化氮报告或讨论可复核的学术证据。", "summary": "该节点将内皮功能与一氧化氮的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2351" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 452 轮补录：内皮功能与一氧化氮；待本地复核。；日期补齐：Crossref 2008-04-11 (published-print, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-281", "title": "《ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging》论文发表", "date_start": "2024-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕内皮功能与一氧化氮报告或讨论可复核的学术证据。", "summary": "该节点将内皮功能与一氧化氮的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2352" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 452 轮补录：内皮功能与一氧化氮；待本地复核。；日期补齐：Crossref 2024-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-282", "title": "《Endothelial Nitric Oxide Synthase in Vascular Disease》论文发表", "date_start": "2006-04-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕内皮功能与一氧化氮报告或讨论可复核的学术证据。", "summary": "该节点将内皮功能与一氧化氮的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2353" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 452 轮补录：内皮功能与一氧化氮；待本地复核。；日期补齐：Crossref 2006-04-04 (published-print, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-283", "title": "《Vascular Endothelial Growth Factor Signaling to Endothelial Nitric Oxide Synthase》论文发表", "date_start": "2006-09-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕内皮功能与一氧化氮报告或讨论可复核的学术证据。", "summary": "该节点将内皮功能与一氧化氮的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2354" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 452 轮补录：内皮功能与一氧化氮；待本地复核。；日期补齐：Crossref 2006-09-29 (published-print, day, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-284", "title": "《ZFYVE21 Sustains Akt-Endothelial Nitric Oxide Synthase (ENOS) Signaling to Promote Vascular Barrier Function in the Kidneys during Aging》论文发表", "date_start": "2024-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕内皮功能与一氧化氮报告或讨论可复核的学术证据。", "summary": "该节点将内皮功能与一氧化氮的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2355" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 452 轮补录：内皮功能与一氧化氮；待本地复核。；日期补齐：Crossref 2024-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:05Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-285", "title": "《Cardiomyocyte Regeneration》论文发表", "date_start": "2017-08-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕心脏再生与心肌细胞更新报告或讨论可复核的学术证据。", "summary": "该节点将心脏再生与心肌细胞更新的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2356" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 453 轮补录：心脏再生与心肌细胞更新；待本地复核。；日期补齐：Crossref 2017-08-15 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-286", "title": "《Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration》论文发表", "date_start": "2020-04-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕心脏再生与心肌细胞更新报告或讨论可复核的学术证据。", "summary": "该节点将心脏再生与心肌细胞更新的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2357" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 453 轮补录：心脏再生与心肌细胞更新；待本地复核。；日期补齐：Crossref 2020-04-14 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-287", "title": "《Abstract 131: Cardiomyocyte Renewal and Cardiac Outcomes Following Injury in Young Swine》论文发表", "date_start": "2019-08-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕心脏再生与心肌细胞更新报告或讨论可复核的学术证据。", "summary": "该节点将心脏再生与心肌细胞更新的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2358" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 453 轮补录：心脏再生与心肌细胞更新；待本地复核。；日期补齐：Crossref 2019-08-02 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-288", "title": "《Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration》论文发表", "date_start": "2021-01-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕心脏再生与心肌细胞更新报告或讨论可复核的学术证据。", "summary": "该节点将心脏再生与心肌细胞更新的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2359" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 453 轮补录：心脏再生与心肌细胞更新；待本地复核。；日期补齐：Crossref 2021-01-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-289", "title": "《Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration》论文发表", "date_start": "2022-12-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕心脏再生与心肌细胞更新报告或讨论可复核的学术证据。", "summary": "该节点将心脏再生与心肌细胞更新的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2360" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 453 轮补录：心脏再生与心肌细胞更新；待本地复核。；日期补齐：Crossref 2022-12-20 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-290", "title": "《Sacubitril/Valsartan, Cardiac Fibrosis, and Remodeling in Heart Failure》论文发表", "date_start": "2019-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕心脏纤维化与心肌重塑报告或讨论可复核的学术证据。", "summary": "该节点将心脏纤维化与心肌重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2361" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 454 轮补录：心脏纤维化与心肌重塑；待本地复核。；日期补齐：Crossref 2019-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-291", "title": "《PUFA Supplementation and Heart Failure: Effects on Fibrosis and Cardiac Remodeling》论文发表", "date_start": "2021-08-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕心脏纤维化与心肌重塑报告或讨论可复核的学术证据。", "summary": "该节点将心脏纤维化与心肌重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2362" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 454 轮补录：心脏纤维化与心肌重塑；待本地复核。；日期补齐：Crossref 2021-08-26 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-292", "title": "《Exercise‐Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart》论文发表", "date_start": "2025-03-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕心脏纤维化与心肌重塑报告或讨论可复核的学术证据。", "summary": "该节点将心脏纤维化与心肌重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2363" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 454 轮补录：心脏纤维化与心肌重塑；待本地复核。；日期补齐：Crossref 2025-03-13 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-293", "title": "《P1093Influence of glycogen content in mouse heart on post-MI fibrosis and cardiac remodeling》论文发表", "date_start": "2017-08-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕心脏纤维化与心肌重塑报告或讨论可复核的学术证据。", "summary": "该节点将心脏纤维化与心肌重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2364" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 454 轮补录：心脏纤维化与心肌重塑；待本地复核。；日期补齐：Crossref 2017-08-29 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-294", "title": "《Cardiac Fibrosis: Key Role of Integrins in Cardiac Homeostasis and Remodeling》论文发表", "date_start": "2021-03-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕心脏纤维化与心肌重塑报告或讨论可复核的学术证据。", "summary": "该节点将心脏纤维化与心肌重塑的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2365" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "循环、心脏与血管维护", "notes": "第 454 轮补录：心脏纤维化与心肌重塑；待本地复核。；日期补齐：Crossref 2021-03-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-295", "title": "《Angiogenesis in Lung Regeneration and Aging》论文发表", "date_start": "2026-07-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肺老化与肺再生报告或讨论可复核的学术证据。", "summary": "该节点将肺老化与肺再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2366" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "呼吸、肺与氧合维护", "notes": "第 455 轮补录：肺老化与肺再生；待本地复核。；日期补齐：Crossref 2026-07-09 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-296", "title": "《Lung Repair and Regeneration in ARDS》论文发表", "date_start": "2019-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肺老化与肺再生报告或讨论可复核的学术证据。", "summary": "该节点将肺老化与肺再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2367" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "呼吸、肺与氧合维护", "notes": "第 455 轮补录：肺老化与肺再生；待本地复核。；日期补齐：Crossref 2019-03 (published-print, month, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-297", "title": "《Comparative biology of tissue repair, regeneration and aging》论文发表", "date_start": "2016-06-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肺老化与肺再生报告或讨论可复核的学术证据。", "summary": "该节点将肺老化与肺再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2368" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "呼吸、肺与氧合维护", "notes": "第 455 轮补录：肺老化与肺再生；待本地复核。；日期补齐：Crossref 2016-06-09 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-298", "title": "《Endothelial FoxM1 reactivates aging-impaired endothelial regeneration for vascular repair and resolution of inflammatory lung injury》论文发表", "date_start": "2023-08-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肺老化与肺再生报告或讨论可复核的学术证据。", "summary": "该节点将肺老化与肺再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2369" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "呼吸、肺与氧合维护", "notes": "第 455 轮补录：肺老化与肺再生；待本地复核。；日期补齐：Crossref 2023-08-16 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-299", "title": "《Regeneration of the Aging Lung: A Mini-Review》论文发表", "date_start": "2016-11-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肺老化与肺再生报告或讨论可复核的学术证据。", "summary": "该节点将肺老化与肺再生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2370" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "呼吸、肺与氧合维护", "notes": "第 455 轮补录：肺老化与肺再生；待本地复核。；日期补齐：Crossref 2016-11-09 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-300", "title": "《Respiratory muscle fatigue and ventilatory failure》论文发表", "date_start": "1990-03-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕呼吸肌与通气能力报告或讨论可复核的学术证据。", "summary": "该节点将呼吸肌与通气能力的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2371" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "呼吸、肺与氧合维护", "notes": "第 456 轮补录：呼吸肌与通气能力；待本地复核。；日期补齐：Crossref 1990-03-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-301", "title": "《Respiratory muscle weakness and normal ventilatory drive in dilative cardiomyopathy》论文发表", "date_start": "1997-08-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕呼吸肌与通气能力报告或讨论可复核的学术证据。", "summary": "该节点将呼吸肌与通气能力的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2372" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "呼吸、肺与氧合维护", "notes": "第 456 轮补录：呼吸肌与通气能力；待本地复核。；日期补齐：Crossref 1997-08-02 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-302", "title": "《Respiratory muscle strength and ventilatory failure in amyotrophic lateral sclerosis》论文发表", "date_start": "2001-10-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕呼吸肌与通气能力报告或讨论可复核的学术证据。", "summary": "该节点将呼吸肌与通气能力的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2373" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "呼吸、肺与氧合维护", "notes": "第 456 轮补录：呼吸肌与通气能力；待本地复核。；日期补齐：Crossref 2001-10-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-303", "title": "《Pulmonary rehabilitation in chronic respiratory insufficiency. 3. Ventilatory muscle training.》论文发表", "date_start": "1993-10-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕呼吸肌与通气能力报告或讨论可复核的学术证据。", "summary": "该节点将呼吸肌与通气能力的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2374" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "呼吸、肺与氧合维护", "notes": "第 456 轮补录：呼吸肌与通气能力；待本地复核。；日期补齐：Crossref 1993-10-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-304", "title": "《Respiratory muscle training improves aerobic capacity and respiratory muscle strength in youth wrestlers》论文发表", "date_start": "2025-03-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕呼吸肌与通气能力报告或讨论可复核的学术证据。", "summary": "该节点将呼吸肌与通气能力的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2375" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "呼吸、肺与氧合维护", "notes": "第 456 轮补录：呼吸肌与通气能力；待本地复核。；日期补齐：Crossref 2025-03-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-305", "title": "《Lineage-Tracing of p16INK4a-Positive Cells Reveals Nephron-by-Nephron Heterogeneity in Kidney Aging》论文发表", "date_start": "2025-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肾脏老化与肾单位韧性报告或讨论可复核的学术证据。", "summary": "该节点将肾脏老化与肾单位韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2376" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏、代谢与排泄维护", "notes": "第 457 轮补录：肾脏老化与肾单位韧性；待本地复核。；日期补齐：Crossref 2025-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-306", "title": "《Lineage-Tracing Experiments of Senescent Cell Marker p16INK4a-Positive Cells Show that Kidney Aging Proceeds on a Nephron-by-Nephron Basis》论文发表", "date_start": "2023-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肾脏老化与肾单位韧性报告或讨论可复核的学术证据。", "summary": "该节点将肾脏老化与肾单位韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2377" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏、代谢与排泄维护", "notes": "第 457 轮补录：肾脏老化与肾单位韧性；待本地复核。；日期补齐：Crossref 2023-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-307", "title": "《Nephron Protection in Diabetic Kidney Disease》论文发表", "date_start": "2016-11-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肾脏老化与肾单位韧性报告或讨论可复核的学术证据。", "summary": "该节点将肾脏老化与肾单位韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2378" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏、代谢与排泄维护", "notes": "第 457 轮补录：肾脏老化与肾单位韧性；待本地复核。；日期补齐：Crossref 2016-11-24 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-308", "title": "《Larger nephron size, low nephron number, and nephrosclerosis on biopsy as predictors of kidney function after donating a kidney》论文发表", "date_start": "2019-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肾脏老化与肾单位韧性报告或讨论可复核的学术证据。", "summary": "该节点将肾脏老化与肾单位韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2379" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏、代谢与排泄维护", "notes": "第 457 轮补录：肾脏老化与肾单位韧性；待本地复核。；日期补齐：Crossref 2019-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-309", "title": "《Low birth weight, nephron number, and kidney disease》论文发表", "date_start": "2005-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肾脏老化与肾单位韧性报告或讨论可复核的学术证据。", "summary": "该节点将肾脏老化与肾单位韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2380" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "肾脏、代谢与排泄维护", "notes": "第 457 轮补录：肾脏老化与肾单位韧性；待本地复核。；日期补齐：Crossref 2005-08 (published-print, month, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-310", "title": "《Metabolic Remodeling during Liver Regeneration》论文发表", "date_start": "2018-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肝脏再生与代谢韧性报告或讨论可复核的学术证据。", "summary": "该节点将肝脏再生与代谢韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2381" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、代谢与解毒维护", "notes": "第 458 轮补录：肝脏再生与代谢韧性；待本地复核。；日期补齐：Crossref 2018-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-311", "title": "《Metabolic inflexibility promotes mitochondrial health during liver regeneration》论文发表", "date_start": "2024-06-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肝脏再生与代谢韧性报告或讨论可复核的学术证据。", "summary": "该节点将肝脏再生与代谢韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2382" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、代谢与解毒维护", "notes": "第 458 轮补录：肝脏再生与代谢韧性；待本地复核。；日期补齐：Crossref 2024-06-14 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-312", "title": "《Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration》论文发表", "date_start": "2023-05-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肝脏再生与代谢韧性报告或讨论可复核的学术证据。", "summary": "该节点将肝脏再生与代谢韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2383" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、代谢与解毒维护", "notes": "第 458 轮补录：肝脏再生与代谢韧性；待本地复核。；日期补齐：Crossref 2023-05-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-313", "title": "《Decoding the metabolic dialogue between hepatocytes and macrophages driving liver regeneration》论文发表", "date_start": "2026-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肝脏再生与代谢韧性报告或讨论可复核的学术证据。", "summary": "该节点将肝脏再生与代谢韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2384" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、代谢与解毒维护", "notes": "第 458 轮补录：肝脏再生与代谢韧性；待本地复核。；日期补齐：Crossref 2026-02 (published-print, month, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-314", "title": "《Liver regeneration》论文发表", "date_start": "2012-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕肝脏再生与代谢韧性报告或讨论可复核的学术证据。", "summary": "该节点将肝脏再生与代谢韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2385" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "消化、代谢与解毒维护", "notes": "第 458 轮补录：肝脏再生与代谢韧性；待本地复核。；日期补齐：Crossref 2012-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-315", "title": "《251-LB: Tracking Beta-Cell Regeneration in Human Pancreatic Slices using Adenovirus Transduction》论文发表", "date_start": "2022-06-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胰岛β细胞保存报告或讨论可复核的学术证据。", "summary": "该节点将胰岛β细胞保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2386" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 459 轮补录：胰岛β细胞保存；待本地复核。；日期补齐：Crossref 2022-06-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-316", "title": "《Beta cell regeneration meets autoimmunity: PAX4 variants in type 1 diabetes》论文发表", "date_start": "2005-04-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胰岛β细胞保存报告或讨论可复核的学术证据。", "summary": "该节点将胰岛β细胞保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2387" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 459 轮补录：胰岛β细胞保存；待本地复核。；日期补齐：Crossref 2005-04-19 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-317", "title": "《Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas》论文发表", "date_start": "2017-10-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胰岛β细胞保存报告或讨论可复核的学术证据。", "summary": "该节点将胰岛β细胞保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2388" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 459 轮补录：胰岛β细胞保存；待本地复核。；日期补齐：Crossref 2017-10-03 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-318", "title": "《2142-LB: GPR75 Signaling Mediates Beta-Cell Regeneration》论文发表", "date_start": "2025-06-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胰岛β细胞保存报告或讨论可复核的学术证据。", "summary": "该节点将胰岛β细胞保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2389" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 459 轮补录：胰岛β细胞保存；待本地复核。；日期补齐：Crossref 2025-06-20 (published-print, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-319", "title": "《Pancreatic alpha cell glucagon–liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes》论文发表", "date_start": "2022-11-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胰岛β细胞保存报告或讨论可复核的学术证据。", "summary": "该节点将胰岛β细胞保存的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2390" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 459 轮补录：胰岛β细胞保存；待本地复核。；日期补齐：Crossref 2022-11-04 (published-online, day, v3)", "created_at": "2026-08-07T08:22:06Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-320", "title": "《Thyroid Function in Aging: A Discerning Approach》论文发表", "date_start": "2018-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕甲状腺与内分泌老化报告或讨论可复核的学术证据。", "summary": "该节点将甲状腺与内分泌老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2391" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 460 轮补录：甲状腺与内分泌老化；待本地复核。；日期补齐：Crossref 2018-02 (published-online, month, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-321", "title": "《Thyroid autoimmunity, thyroid function, and endometriosis: reproductive immune-endocrine crosstalk and causal uncertainty》论文发表", "date_start": "2026-08-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕甲状腺与内分泌老化报告或讨论可复核的学术证据。", "summary": "该节点将甲状腺与内分泌老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2392" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 460 轮补录：甲状腺与内分泌老化；待本地复核。；日期补齐：Crossref 2026-08-07 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-322", "title": "《Thyroid Function and Morphology in Gaucher Disease: Exploring the Endocrine Implications》论文发表", "date_start": "2024-12-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕甲状腺与内分泌老化报告或讨论可复核的学术证据。", "summary": "该节点将甲状腺与内分泌老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2393" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 460 轮补录：甲状腺与内分泌老化；待本地复核。；日期补齐：Crossref 2024-12-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-323", "title": "《Thyroid Response to Peripheral Endocrine Factors: Neuropeptide Y Influences Thyroid Function in the Reptile Podarcis siculus》论文发表", "date_start": "2025-11-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕甲状腺与内分泌老化报告或讨论可复核的学术证据。", "summary": "该节点将甲状腺与内分泌老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2394" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 460 轮补录：甲状腺与内分泌老化；待本地复核。；日期补齐：Crossref 2025-11-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-324", "title": "《Circadian rhythm of the Leydig cells endocrine function is attenuated during aging》论文发表", "date_start": "2016-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕甲状腺与内分泌老化报告或讨论可复核的学术证据。", "summary": "该节点将甲状腺与内分泌老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2395" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 460 轮补录：甲状腺与内分泌老化；待本地复核。；日期补齐：Crossref 2016-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-325", "title": "《Adrenal Aging and Its Implications on Stress Responsiveness in Humans》论文发表", "date_start": "2019-02-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肾上腺与应激激素韧性报告或讨论可复核的学术证据。", "summary": "该节点将肾上腺与应激激素韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2396" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 461 轮补录：肾上腺与应激激素韧性；待本地复核。；日期补齐：Crossref 2019-02-07 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-326", "title": "《Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland》论文发表", "date_start": "2024-03-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肾上腺与应激激素韧性报告或讨论可复核的学术证据。", "summary": "该节点将肾上腺与应激激素韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2397" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 461 轮补录：肾上腺与应激激素韧性；待本地复核。；日期补齐：Crossref 2024-03-19 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-327", "title": "《Aging and the adrenal cortex》论文发表", "date_start": "1998-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肾上腺与应激激素韧性报告或讨论可复核的学术证据。", "summary": "该节点将肾上腺与应激激素韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2398" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 461 轮补录：肾上腺与应激激素韧性；待本地复核。；日期补齐：Crossref 1998-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-328", "title": "《Aging and Adrenal Aldosterone Production》论文发表", "date_start": "2018-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肾上腺与应激激素韧性报告或讨论可复核的学术证据。", "summary": "该节点将肾上腺与应激激素韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2399" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 461 轮补录：肾上腺与应激激素韧性；待本地复核。；日期补齐：Crossref 2018-02 (published-print, month, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-329", "title": "《Harnessing the power of nutritional antioxidants against adrenal hormone imbalance-associated oxidative stress》论文发表", "date_start": "2023-11-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕肾上腺与应激激素韧性报告或讨论可复核的学术证据。", "summary": "该节点将肾上腺与应激激素韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2400" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "内分泌、代谢与稳态维护", "notes": "第 461 轮补录：肾上腺与应激激素韧性；待本地复核。；日期补齐：Crossref 2023-11-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-330", "title": "《SEX DIFFERENCES IN AGING-RELATED DISEASE AND HEALTHSPAN》论文发表", "date_start": "2016-11-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕性激素下降与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将性激素下降与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2401" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖、内分泌与未来选择权", "notes": "第 462 轮补录：性激素下降与健康寿命；待本地复核。；日期补齐：Crossref 2016-11-01 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-331", "title": "《Abstract 10441: Sex-Specific Decline in Coronary Flow Reserve with Aging》论文发表", "date_start": "2021-11-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕性激素下降与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将性激素下降与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2402" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖、内分泌与未来选择权", "notes": "第 462 轮补录：性激素下降与健康寿命；待本地复核。；日期补齐：Crossref 2021-11-16 (published-print, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-332", "title": "《Steroid hormone levels vary with sex, aging, lifestyle, and genetics》论文发表", "date_start": "2025-03-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕性激素下降与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将性激素下降与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2403" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖、内分泌与未来选择权", "notes": "第 462 轮补录：性激素下降与健康寿命；待本地复核。；日期补齐：Crossref 2025-03-28 (published-print, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-333", "title": "《Reproductive aging is associated with a decline in per follicle antimullerian hormone》论文发表", "date_start": "2018-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕性激素下降与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将性激素下降与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2404" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖、内分泌与未来选择权", "notes": "第 462 轮补录：性激素下降与健康寿命；待本地复核。；日期补齐：Crossref 2018-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-334", "title": "《NUTRITIONAL INTERVENTIONS IN AGING: HEALTHSPAN AND DISEASE VULNERABILITY》论文发表", "date_start": "2016-11-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕性激素下降与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将性激素下降与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2405" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生殖、内分泌与未来选择权", "notes": "第 462 轮补录：性激素下降与健康寿命；待本地复核。；日期补齐：Crossref 2016-11-01 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-335", "title": "《Bone Marrow Fat and Hematopoiesis》论文发表", "date_start": "2018-11-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕骨髓老化与造血维持报告或讨论可复核的学术证据。", "summary": "该节点将骨髓老化与造血维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2406" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 463 轮补录：骨髓老化与造血维持；待本地复核。；日期补齐：Crossref 2018-11-28 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-336", "title": "《Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment》论文发表", "date_start": "2016-11-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕骨髓老化与造血维持报告或讨论可复核的学术证据。", "summary": "该节点将骨髓老化与造血维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2407" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 463 轮补录：骨髓老化与造血维持；待本地复核。；日期补齐：Crossref 2016-11-14 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-337", "title": "《Bone marrow hematopoiesis drives multiple sclerosis progression》论文发表", "date_start": "2022-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕骨髓老化与造血维持报告或讨论可复核的学术证据。", "summary": "该节点将骨髓老化与造血维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2408" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 463 轮补录：骨髓老化与造血维持；待本地复核。；日期补齐：Crossref 2022-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-338", "title": "《Cell-Extrinsic Stressors from the Aging Bone Marrow (BM) Microenvironment Promote Dnmt3a-Mutant Clonal Hematopoiesis》论文发表", "date_start": "2019-11-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕骨髓老化与造血维持报告或讨论可复核的学术证据。", "summary": "该节点将骨髓老化与造血维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2409" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 463 轮补录：骨髓老化与造血维持；待本地复核。；日期补齐：Crossref 2019-11-13 (published-print, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-339", "title": "《Clonal hematopoiesis in the inherited bone marrow failure syndromes》论文发表", "date_start": "2020-07-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕骨髓老化与造血维持报告或讨论可复核的学术证据。", "summary": "该节点将骨髓老化与造血维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2410" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 463 轮补录：骨髓老化与造血维持；待本地复核。；日期补齐：Crossref 2020-07-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-340", "title": "《Human Thymic Involution and Aging in Humanized Mice》论文发表", "date_start": "2020-07-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胸腺退化与T细胞生产报告或讨论可复核的学术证据。", "summary": "该节点将胸腺退化与T细胞生产的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2411" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 464 轮补录：胸腺退化与T细胞生产；待本地复核。；日期补齐：Crossref 2020-07-07 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-341", "title": "《Ultrastructural study of thymic microenvironment involution in aging mice》论文发表", "date_start": "1996-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胸腺退化与T细胞生产报告或讨论可复核的学术证据。", "summary": "该节点将胸腺退化与T细胞生产的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2412" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 464 轮补录：胸腺退化与T细胞生产；待本地复核。；日期补齐：Crossref 1996-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-342", "title": "《Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the “obesity paradox”》论文发表", "date_start": "2023-01-26", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胸腺退化与T细胞生产报告或讨论可复核的学术证据。", "summary": "该节点将胸腺退化与T细胞生产的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2413" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 464 轮补录：胸腺退化与T细胞生产；待本地复核。；日期补齐：Crossref 2023-01-26 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-343", "title": "《Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice》论文发表", "date_start": "2000-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胸腺退化与T细胞生产报告或讨论可复核的学术证据。", "summary": "该节点将胸腺退化与T细胞生产的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2414" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 464 轮补录：胸腺退化与T细胞生产；待本地复核。；日期补齐：Crossref 2000-03 (published-print, month, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-344", "title": "《IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection》论文发表", "date_start": "2022-11-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕胸腺退化与T细胞生产报告或讨论可复核的学术证据。", "summary": "该节点将胸腺退化与T细胞生产的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2415" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 464 轮补录：胸腺退化与T细胞生产；待本地复核。；日期补齐：Crossref 2022-11-12 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-345", "title": "《Diversity of the Immune Repertoire and Immunoregulation》论文发表", "date_start": "2003-03-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕免疫组库多样性与老化报告或讨论可复核的学术证据。", "summary": "该节点将免疫组库多样性与老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2416" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 465 轮补录：免疫组库多样性与老化；待本地复核。；日期补齐：Crossref 2003-03-13 (published-print, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-346", "title": "《Quantifiable blood TCR repertoire components associate with immune aging》论文发表", "date_start": "2024-09-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕免疫组库多样性与老化报告或讨论可复核的学术证据。", "summary": "该节点将免疫组库多样性与老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2417" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 465 轮补录：免疫组库多样性与老化；待本地复核。；日期补齐：Crossref 2024-09-17 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-347", "title": "《Shattuck Lecture — Diversity of the Immune Repertoire and Immunoregulation》论文发表", "date_start": "2003-05-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕免疫组库多样性与老化报告或讨论可复核的学术证据。", "summary": "该节点将免疫组库多样性与老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2418" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 465 轮补录：免疫组库多样性与老化；待本地复核。；日期补齐：Crossref 2003-05-15 (published-print, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-348", "title": "《An Aging Clock Based on Immune Repertoire Features: COVID ‐19 Accelerates Aging》论文发表", "date_start": "2026-06-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕免疫组库多样性与老化报告或讨论可复核的学术证据。", "summary": "该节点将免疫组库多样性与老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2419" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 465 轮补录：免疫组库多样性与老化；待本地复核。；日期补齐：Crossref 2026-06-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-349", "title": "《Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease》论文发表", "date_start": "2007-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕免疫组库多样性与老化报告或讨论可复核的学术证据。", "summary": "该节点将免疫组库多样性与老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2420" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 465 轮补录：免疫组库多样性与老化；待本地复核。；日期补齐：Crossref 2007-03 (published-print, month, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-350", "title": "《Stress, NK Receptors, and Immune Surveillance》论文发表", "date_start": "2001-10-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕NK细胞功能与免疫监视报告或讨论可复核的学术证据。", "summary": "该节点将NK细胞功能与免疫监视的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2421" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 466 轮补录：NK细胞功能与免疫监视；待本地复核。；日期补齐：Crossref 2001-10-19 (published-print, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-351", "title": "《Evasion of NK cell immune surveillance via the vimentin-mediated cytoskeleton remodeling》论文发表", "date_start": "2022-08-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕NK细胞功能与免疫监视报告或讨论可复核的学术证据。", "summary": "该节点将NK细胞功能与免疫监视的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2422" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 466 轮补录：NK细胞功能与免疫监视；待本地复核。；日期补齐：Crossref 2022-08-11 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-352", "title": "《RANKL Expressed by Acute Myeloid Leukemia Cells Impairs NK Cell-Mediated Immune Surveillance》论文发表", "date_start": "2010-11-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕NK细胞功能与免疫监视报告或讨论可复核的学术证据。", "summary": "该节点将NK细胞功能与免疫监视的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2423" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 466 轮补录：NK细胞功能与免疫监视；待本地复核。；日期补齐：Crossref 2010-11-19 (published-print, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-353", "title": "《NK Cell-Based Immune Checkpoint Inhibition》论文发表", "date_start": "2020-02-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕NK细胞功能与免疫监视报告或讨论可复核的学术证据。", "summary": "该节点将NK细胞功能与免疫监视的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2424" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 466 轮补录：NK细胞功能与免疫监视；待本地复核。；日期补齐：Crossref 2020-02-13 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-354", "title": "《Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells》论文发表", "date_start": "2019-10-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕NK细胞功能与免疫监视报告或讨论可复核的学术证据。", "summary": "该节点将NK细胞功能与免疫监视的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2425" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 466 轮补录：NK细胞功能与免疫监视；待本地复核。；日期补齐：Crossref 2019-10-11 (published-online, day, v3)", "created_at": "2026-08-07T08:22:07Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-355", "title": "《Hypoxia directly enhances dendritic cell antigen presentation》论文发表", "date_start": "2013", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕树突状细胞与抗原呈递报告或讨论可复核的学术证据。", "summary": "该节点将树突状细胞与抗原呈递的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2426" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 467 轮补录：树突状细胞与抗原呈递；待本地复核。；日期补齐：Crossref 2013 (published-online, year, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-356", "title": "《Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation》论文发表", "date_start": "2018-08-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕树突状细胞与抗原呈递报告或讨论可复核的学术证据。", "summary": "该节点将树突状细胞与抗原呈递的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2427" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 467 轮补录：树突状细胞与抗原呈递；待本地复核。；日期补齐：Crossref 2018-08-06 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-357", "title": "《Involvement of LOX-1 in Dendritic Cell-Mediated Antigen Cross-Presentation》论文发表", "date_start": "2002-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕树突状细胞与抗原呈递报告或讨论可复核的学术证据。", "summary": "该节点将树突状细胞与抗原呈递的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2428" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 467 轮补录：树突状细胞与抗原呈递；待本地复核。；日期补齐：Crossref 2002-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-358", "title": "《AML Bone Marrow Microenvironment Impairs Dendritic Cell Maturation and Antigen Presentation》论文发表", "date_start": "2012-11-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕树突状细胞与抗原呈递报告或讨论可复核的学术证据。", "summary": "该节点将树突状细胞与抗原呈递的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2429" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 467 轮补录：树突状细胞与抗原呈递；待本地复核。；日期补齐：Crossref 2012-11-16 (published-print, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-359", "title": "《Acquisition and presentation of follicular dendritic cell–bound antigen by lymph node–resident dendritic cells》论文发表", "date_start": "2010-12-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕树突状细胞与抗原呈递报告或讨论可复核的学术证据。", "summary": "该节点将树突状细胞与抗原呈递的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2430" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 467 轮补录：树突状细胞与抗原呈递；待本地复核。；日期补齐：Crossref 2010-12-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-360", "title": "《Antibody Repertoire Revealed》论文发表", "date_start": "2009-05-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕B细胞与抗体组库老化报告或讨论可复核的学术证据。", "summary": "该节点将B细胞与抗体组库老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2431" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 468 轮补录：B细胞与抗体组库老化；待本地复核。；日期补齐：Crossref 2009-05-07 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-361", "title": "《Antibody Repertoire: Embracing Diversity》论文发表", "date_start": "2011-07-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕B细胞与抗体组库老化报告或讨论可复核的学术证据。", "summary": "该节点将B细胞与抗体组库老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2432" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 468 轮补录：B细胞与抗体组库老化；待本地复核。；日期补齐：Crossref 2011-07-27 (published-print, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-362", "title": "《Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth》论文发表", "date_start": "2020-01-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕B细胞与抗体组库老化报告或讨论可复核的学术证据。", "summary": "该节点将B细胞与抗体组库老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2433" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 468 轮补录：B细胞与抗体组库老化；待本地复核。；日期补齐：Crossref 2020-01-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-363", "title": "《Profiling celiac disease antibody repertoire》论文发表", "date_start": "2013-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕B细胞与抗体组库老化报告或讨论可复核的学术证据。", "summary": "该节点将B细胞与抗体组库老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2434" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 468 轮补录：B细胞与抗体组库老化；待本地复核。；日期补齐：Crossref 2013-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-364", "title": "《A public anti-COVID antibody repertoire》论文发表", "date_start": "2021-06-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕B细胞与抗体组库老化报告或讨论可复核的学术证据。", "summary": "该节点将B细胞与抗体组库老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2435" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 468 轮补录：B细胞与抗体组库老化；待本地复核。；日期补齐：Crossref 2021-06-03 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-365", "title": "《Immunosenescence, aging and successful aging》论文发表", "date_start": "2022-08-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕疫苗应答与免疫衰老报告或讨论可复核的学术证据。", "summary": "该节点将疫苗应答与免疫衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2436" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 469 轮补录：疫苗应答与免疫衰老；待本地复核。；日期补齐：Crossref 2022-08-02 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-366", "title": "《Immunosenescence: Role and measurement in influenza vaccine response among the elderly》论文发表", "date_start": "2007-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕疫苗应答与免疫衰老报告或讨论可复核的学术证据。", "summary": "该节点将疫苗应答与免疫衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2437" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 469 轮补录：疫苗应答与免疫衰老；待本地复核。；日期补齐：Crossref 2007-04 (published-print, month, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-367", "title": "《Immune Senescence, Immunosenescence and Aging》论文发表", "date_start": "2022-05-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕疫苗应答与免疫衰老报告或讨论可复核的学术证据。", "summary": "该节点将疫苗应答与免疫衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2438" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 469 轮补录：疫苗应答与免疫衰老；待本地复核。；日期补齐：Crossref 2022-05-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-368", "title": "《Immunosenescence in Aging-Related Vascular Dysfunction》论文发表", "date_start": "2022-10-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕疫苗应答与免疫衰老报告或讨论可复核的学术证据。", "summary": "该节点将疫苗应答与免疫衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2439" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 469 轮补录：疫苗应答与免疫衰老；待本地复核。；日期补齐：Crossref 2022-10-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-369", "title": "《Analyzing Immune Responses to the Seasonal Influenza Vaccine to Understand Immunosenescence》论文发表", "date_start": "2010-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕疫苗应答与免疫衰老报告或讨论可复核的学术证据。", "summary": "该节点将疫苗应答与免疫衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2440" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 469 轮补录：疫苗应答与免疫衰老；待本地复核。；日期补齐：Crossref 2010-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-370", "title": "《Innate immune memory, trained immunity and nomenclature clarification》论文发表", "date_start": "2023-08-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕训练免疫与先天记忆报告或讨论可复核的学术证据。", "summary": "该节点将训练免疫与先天记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2441" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 470 轮补录：训练免疫与先天记忆；待本地复核。；日期补齐：Crossref 2023-08-24 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-371", "title": "《Trained Immunity and Local Innate Immune Memory in the Lung》论文发表", "date_start": "2018-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕训练免疫与先天记忆报告或讨论可复核的学术证据。", "summary": "该节点将训练免疫与先天记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2442" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 470 轮补录：训练免疫与先天记忆；待本地复核。；日期补齐：Crossref 2018-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-372", "title": "《Resident memory macrophages and trained innate immunity at barrier tissues》论文发表", "date_start": "2025-10-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕训练免疫与先天记忆报告或讨论可复核的学术证据。", "summary": "该节点将训练免疫与先天记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2443" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 470 轮补录：训练免疫与先天记忆；待本地复核。；日期补齐：Crossref 2025-10-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-373", "title": "《Trained Innate Immunity Not Always Amicable》论文发表", "date_start": "2019-05-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕训练免疫与先天记忆报告或讨论可复核的学术证据。", "summary": "该节点将训练免疫与先天记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2444" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 470 轮补录：训练免疫与先天记忆；待本地复核。；日期补齐：Crossref 2019-05-24 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-374", "title": "《Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery》论文发表", "date_start": "2024-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕训练免疫与先天记忆报告或讨论可复核的学术证据。", "summary": "该节点将训练免疫与先天记忆的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2445" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、血液与造血维护", "notes": "第 470 轮补录：训练免疫与先天记忆；待本地复核。；日期补齐：Crossref 2024-04 (published-print, month, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-375", "title": "《Inflammaging and Brain Aging》论文发表", "date_start": "2024-09-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕慢性炎症与炎性衰老报告或讨论可复核的学术证据。", "summary": "该节点将慢性炎症与炎性衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2446" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、炎症与组织稳态", "notes": "第 471 轮补录：慢性炎症与炎性衰老；待本地复核。；日期补齐：Crossref 2024-09-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-376", "title": "《Chronic Inflammation and Aging in Rheumatic Diseases》论文发表", "date_start": "2025", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕慢性炎症与炎性衰老报告或讨论可复核的学术证据。", "summary": "该节点将慢性炎症与炎性衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2447" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、炎症与组织稳态", "notes": "第 471 轮补录：慢性炎症与炎性衰老；待本地复核。；日期补齐：Crossref 2025 (published-online, year, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-377", "title": "《Chronic inflammation and the hallmarks of aging》论文发表", "date_start": "2023-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕慢性炎症与炎性衰老报告或讨论可复核的学术证据。", "summary": "该节点将慢性炎症与炎性衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2448" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、炎症与组织稳态", "notes": "第 471 轮补录：慢性炎症与炎性衰老；待本地复核。；日期补齐：Crossref 2023-08 (published-print, month, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-378", "title": "《Chronic inflammation – inflammaging – in the ageing cochlea: A novel target for future presbycusis therapy》论文发表", "date_start": "2017-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕慢性炎症与炎性衰老报告或讨论可复核的学术证据。", "summary": "该节点将慢性炎症与炎性衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2449" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、炎症与组织稳态", "notes": "第 471 轮补录：慢性炎症与炎性衰老；待本地复核。；日期补齐：Crossref 2017-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-379", "title": "《The Potential Roles of Probiotics, Resistant Starch, and Resistant Proteins in Ameliorating Inflammation during Aging (Inflammaging)》论文发表", "date_start": "2022-02-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕慢性炎症与炎性衰老报告或讨论可复核的学术证据。", "summary": "该节点将慢性炎症与炎性衰老的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2450" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "免疫、炎症与组织稳态", "notes": "第 471 轮补录：慢性炎症与炎性衰老；待本地复核。；日期补齐：Crossref 2022-02-10 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-380", "title": "《RNF41 orchestrates macrophage-driven fibrosis resolution and hepatic regeneration》论文发表", "date_start": "2023-07-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕纤维化消退与器官修复报告或讨论可复核的学术证据。", "summary": "该节点将纤维化消退与器官修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2451" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞与组织重构", "notes": "第 472 轮补录：纤维化消退与器官修复；待本地复核。；日期补齐：Crossref 2023-07-12 (published-print, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-381", "title": "《Comprehensive Review of the Vascular Niche in Regulating Organ Regeneration and Fibrosis》论文发表", "date_start": "2022-09-28", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕纤维化消退与器官修复报告或讨论可复核的学术证据。", "summary": "该节点将纤维化消退与器官修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2452" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞与组织重构", "notes": "第 472 轮补录：纤维化消退与器官修复；待本地复核。；日期补齐：Crossref 2022-09-28 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-382", "title": "《Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice》论文发表", "date_start": "2014-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕纤维化消退与器官修复报告或讨论可复核的学术证据。", "summary": "该节点将纤维化消退与器官修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2453" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞与组织重构", "notes": "第 472 轮补录：纤维化消退与器官修复；待本地复核。；日期补齐：Crossref 2014-05 (published-print, month, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-383", "title": "《Liver fibrosis and repair: immune regulation of wound healing in a solid organ》论文发表", "date_start": "2014-02-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕纤维化消退与器官修复报告或讨论可复核的学术证据。", "summary": "该节点将纤维化消退与器官修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2454" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞与组织重构", "notes": "第 472 轮补录：纤维化消退与器官修复；待本地复核。；日期补齐：Crossref 2014-02-25 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-384", "title": "《Chaperone-mediated autophagy supports organ regeneration and fibroblast quiescence in mouse models of fibrosis》论文发表", "date_start": "2026-02-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "reconstruction", "event_type": "literature", "claim": "该文献围绕纤维化消退与器官修复报告或讨论可复核的学术证据。", "summary": "该节点将纤维化消退与器官修复的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2455" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "细胞与组织重构", "notes": "第 472 轮补录：纤维化消退与器官修复；待本地复核。；日期补齐：Crossref 2026-02-18 (published-print, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-385", "title": "《Adipose tissue browning and metabolic health》论文发表", "date_start": "2013-10-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脂肪组织老化与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将脂肪组织老化与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2456" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 473 轮补录：脂肪组织老化与代谢健康；待本地复核。；日期补齐：Crossref 2013-10-22 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-386", "title": "《Aging epicardial adipose tissue: a metabolic-endocrine network driving vascular calcification》论文发表", "date_start": "2026-04-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脂肪组织老化与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将脂肪组织老化与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2457" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 473 轮补录：脂肪组织老化与代谢健康；待本地复核。；日期补齐：Crossref 2026-04-17 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-387", "title": "《Intermuscular adipose tissue in healthy human aging—effects of exercise training and implications to metabolic health》论文发表", "date_start": "2025-11-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脂肪组织老化与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将脂肪组织老化与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2458" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 473 轮补录：脂肪组织老化与代谢健康；待本地复核。；日期补齐：Crossref 2025-11-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-388", "title": "《Adipose tissue ageing: implications for metabolic health and lifespan》论文发表", "date_start": "2025-06-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脂肪组织老化与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将脂肪组织老化与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2459" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 473 轮补录：脂肪组织老化与代谢健康；待本地复核。；日期补齐：Crossref 2025-06-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-389", "title": "《Thermogenic adipose tissue in energy regulation and metabolic health》论文发表", "date_start": "2023-03-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕脂肪组织老化与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将脂肪组织老化与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2460" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 473 轮补录：脂肪组织老化与代谢健康；待本地复核。；日期补齐：Crossref 2023-03-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:08Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-390", "title": "《SnapShot: Brown and Beige Adipose Thermogenesis》论文发表", "date_start": "2016-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕棕色脂肪与产热报告或讨论可复核的学术证据。", "summary": "该节点将棕色脂肪与产热的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2461" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 474 轮补录：棕色脂肪与产热；待本地复核。；日期补齐：Crossref 2016-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-391", "title": "《Brown adipose tissue thermogenesis in humans》论文发表", "date_start": "2013-08-10", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕棕色脂肪与产热报告或讨论可复核的学术证据。", "summary": "该节点将棕色脂肪与产热的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2462" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 474 轮补录：棕色脂肪与产热；待本地复核。；日期补齐：Crossref 2013-08-10 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-392", "title": "《Central Control of Brown Adipose Tissue Thermogenesis》论文发表", "date_start": "2012", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕棕色脂肪与产热报告或讨论可复核的学术证据。", "summary": "该节点将棕色脂肪与产热的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2463" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 474 轮补录：棕色脂肪与产热；待本地复核。；日期补齐：Crossref 2012 (published-online, year, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-393", "title": "《Electrical Neurostimulation Promotes Brown Adipose Tissue Thermogenesis》论文发表", "date_start": "2020-09-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕棕色脂肪与产热报告或讨论可复核的学术证据。", "summary": "该节点将棕色脂肪与产热的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2464" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 474 轮补录：棕色脂肪与产热；待本地复核。；日期补齐：Crossref 2020-09-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-394", "title": "《Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis》论文发表", "date_start": "2018-05", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕棕色脂肪与产热报告或讨论可复核的学术证据。", "summary": "该节点将棕色脂肪与产热的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2465" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、脂质与膜维护", "notes": "第 474 轮补录：棕色脂肪与产热；待本地复核。；日期补齐：Crossref 2018-05 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-395", "title": "《Neuronal control of peripheral insulin sensitivity and glucose metabolism》论文发表", "date_start": "2017-05-04", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕糖代谢与胰岛素敏感性报告或讨论可复核的学术证据。", "summary": "该节点将糖代谢与胰岛素敏感性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2466" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 475 轮补录：糖代谢与胰岛素敏感性；待本地复核。；日期补齐：Crossref 2017-05-04 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-396", "title": "《Insulin Sensitivity, Glucose Metabolism, and Membrane Fluidity in Hypertensive Subjects》论文发表", "date_start": "2004-05-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕糖代谢与胰岛素敏感性报告或讨论可复核的学术证据。", "summary": "该节点将糖代谢与胰岛素敏感性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2467" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 475 轮补录：糖代谢与胰岛素敏感性；待本地复核。；日期补齐：Crossref 2004-05-25 (published-print, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-397", "title": "《ATORVASTATIN WORSENS GLUCOSE METABOLISM AND INSULIN SENSITIVITY IN HYPERCHOLESTEROLEMIC PATIENTS》论文发表", "date_start": "2010-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕糖代谢与胰岛素敏感性报告或讨论可复核的学术证据。", "summary": "该节点将糖代谢与胰岛素敏感性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2468" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 475 轮补录：糖代谢与胰岛素敏感性；待本地复核。；日期补齐：Crossref 2010-03 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-398", "title": "《Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity》论文发表", "date_start": "2015-02-21", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕糖代谢与胰岛素敏感性报告或讨论可复核的学术证据。", "summary": "该节点将糖代谢与胰岛素敏感性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2469" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 475 轮补录：糖代谢与胰岛素敏感性；待本地复核。；日期补齐：Crossref 2015-02-21 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-399", "title": "《Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism》论文发表", "date_start": "2009-01-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕糖代谢与胰岛素敏感性报告或讨论可复核的学术证据。", "summary": "该节点将糖代谢与胰岛素敏感性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2470" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "代谢、能量与分子维护", "notes": "第 475 轮补录：糖代谢与胰岛素敏感性；待本地复核。；日期补齐：Crossref 2009-01-09 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-400", "title": "《Calorie restriction and longevity: fast and loose?》论文发表", "date_start": "2012-10-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕热量限制与寿命报告或讨论可复核的学术证据。", "summary": "该节点将热量限制与寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2471" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 476 轮补录：热量限制与寿命；待本地复核。；日期补齐：Crossref 2012-10-24 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-401", "title": "《Calorie restriction, SIRT1 and metabolism: understanding longevity》论文发表", "date_start": "2005-03-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕热量限制与寿命报告或讨论可复核的学术证据。", "summary": "该节点将热量限制与寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2472" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 476 轮补录：热量限制与寿命；待本地复核。；日期补齐：Crossref 2005-03-15 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-402", "title": "《Bile acids extend longevity beyond calorie restriction》论文发表", "date_start": "2010-07-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕热量限制与寿命报告或讨论可复核的学术证据。", "summary": "该节点将热量限制与寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2473" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 476 轮补录：热量限制与寿命；待本地复核。；日期补齐：Crossref 2010-07-16 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-403", "title": "《Why calorie restriction would work for human longevity》论文发表", "date_start": "2006-05-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕热量限制与寿命报告或讨论可复核的学术证据。", "summary": "该节点将热量限制与寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2474" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 476 轮补录：热量限制与寿命；待本地复核。；日期补齐：Crossref 2006-05-05 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-404", "title": "《How Can Dietary Calorie Restriction Lead to Longevity?》论文发表", "date_start": "2007-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕热量限制与寿命报告或讨论可复核的学术证据。", "summary": "该节点将热量限制与寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2475" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 476 轮补录：热量限制与寿命；待本地复核。；日期补齐：Crossref 2007-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-405", "title": "《Intermittent Fasting and Metabolic Health》论文发表", "date_start": "2022-01-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕间歇性禁食与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将间歇性禁食与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2476" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 477 轮补录：间歇性禁食与代谢健康；待本地复核。；日期补齐：Crossref 2022-01-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-406", "title": "《Intermittent and periodic fasting, longevity and disease》论文发表", "date_start": "2021-01-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕间歇性禁食与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将间歇性禁食与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2477" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 477 轮补录：间歇性禁食与代谢健康；待本地复核。；日期补齐：Crossref 2021-01-14 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-407", "title": "《Intermittent Fasting and Metabolic Health: From Religious Fast to Time‐Restricted Feeding》论文发表", "date_start": "2020-07-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕间歇性禁食与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将间歇性禁食与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2478" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 477 轮补录：间歇性禁食与代谢健康；待本地复核。；日期补齐：Crossref 2020-07-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-408", "title": "《The cyclic metabolic switching theory of intermittent fasting》论文发表", "date_start": "2025-03-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕间歇性禁食与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将间歇性禁食与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2479" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 477 轮补录：间歇性禁食与代谢健康；待本地复核。；日期补齐：Crossref 2025-03-14 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-409", "title": "《Intermittent fasting and longevity: From animal models to implication for humans》论文发表", "date_start": "2024-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕间歇性禁食与代谢健康报告或讨论可复核的学术证据。", "summary": "该节点将间歇性禁食与代谢健康的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2480" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 477 轮补录：间歇性禁食与代谢健康；待本地复核。；日期补齐：Crossref 2024-04 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-410", "title": "《Diet-based strategies, informed by genetics, to improve healthspan》论文发表", "date_start": "2020-12-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕植物性饮食与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将植物性饮食与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2481" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 478 轮补录：植物性饮食与健康寿命；待本地复核。；日期补齐：Crossref 2020-12-16 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-411", "title": "《HEALTHSPAN MEASURES IN A WESTERN DIET CONDITIONED, IRRADIATED RODENT MODEL OF ACCELERATED AGING》论文发表", "date_start": "2017-06-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕植物性饮食与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将植物性饮食与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2482" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 478 轮补录：植物性饮食与健康寿命；待本地复核。；日期补齐：Crossref 2017-06-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-412", "title": "《Healthy Plant-Based Diet》论文发表", "date_start": "2017-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕植物性饮食与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将植物性饮食与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2483" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 478 轮补录：植物性饮食与健康寿命；待本地复核。；日期补齐：Crossref 2017-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-413", "title": "《Diet and Botanical Supplementation: Combination Therapy for Healthspan Improvement?》论文发表", "date_start": "2021-10-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕植物性饮食与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将植物性饮食与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2484" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 478 轮补录：植物性饮食与健康寿命；待本地复核。；日期补齐：Crossref 2021-10-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-414", "title": "《A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice》论文发表", "date_start": "2017-09", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕植物性饮食与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将植物性饮食与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2485" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 478 轮补录：植物性饮食与健康寿命；待本地复核。；日期补齐：Crossref 2017-09 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-415", "title": "《Perceived Control and Cognitive Aging: The Mediating Role of Mediterranean Diet Adherence》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕地中海饮食与认知老化报告或讨论可复核的学术证据。", "summary": "该节点将地中海饮食与认知老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2486" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 479 轮补录：地中海饮食与认知老化；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-416", "title": "《Mediterranean Diet and Cognitive Decline》论文发表", "date_start": "2009-12-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕地中海饮食与认知老化报告或讨论可复核的学术证据。", "summary": "该节点将地中海饮食与认知老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2487" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 479 轮补录：地中海饮食与认知老化；待本地复核。；日期补齐：Crossref 2009-12-09 (published-print, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-417", "title": "《Components of a Mediterranean diet and their impact on cognitive functions in aging》论文发表", "date_start": "2015-07-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕地中海饮食与认知老化报告或讨论可复核的学术证据。", "summary": "该节点将地中海饮食与认知老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2488" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 479 轮补录：地中海饮食与认知老化；待本地复核。；日期补齐：Crossref 2015-07-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-418", "title": "《Mediterranean Diet and Cognitive Decline—Reply》论文发表", "date_start": "2009-12-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕地中海饮食与认知老化报告或讨论可复核的学术证据。", "summary": "该节点将地中海饮食与认知老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2489" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 479 轮补录：地中海饮食与认知老化；待本地复核。；日期补齐：Crossref 2009-12-09 (published-print, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-419", "title": "《Mediterranean Diet and Age-Related Cognitive Decline》论文发表", "date_start": "2015-07-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕地中海饮食与认知老化报告或讨论可复核的学术证据。", "summary": "该节点将地中海饮食与认知老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2490" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 479 轮补录：地中海饮食与认知老化；待本地复核。；日期补齐：Crossref 2015-07-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-420", "title": "《Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults》论文发表", "date_start": "2007-04", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕欧米伽3与炎症平衡报告或讨论可复核的学术证据。", "summary": "该节点将欧米伽3与炎症平衡的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2491" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 480 轮补录：欧米伽3与炎症平衡；待本地复核。；日期补齐：Crossref 2007-04 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-421", "title": "《Omega-3 Fatty Acids and Heart Health》论文发表", "date_start": "2015-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕欧米伽3与炎症平衡报告或讨论可复核的学术证据。", "summary": "该节点将欧米伽3与炎症平衡的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2492" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 480 轮补录：欧米伽3与炎症平衡；待本地复核。；日期补齐：Crossref 2015-12 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-422", "title": "《Do Omega-3 Fatty Acids Benefit Health?》论文发表", "date_start": "2020-12-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕欧米伽3与炎症平衡报告或讨论可复核的学术证据。", "summary": "该节点将欧米伽3与炎症平衡的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2493" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 480 轮补录：欧米伽3与炎症平衡；待本地复核。；日期补齐：Crossref 2020-12-08 (published-print, day, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-423", "title": "《Omega-3 fatty acids and inflammation》论文发表", "date_start": "2004-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕欧米伽3与炎症平衡报告或讨论可复核的学术证据。", "summary": "该节点将欧米伽3与炎症平衡的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2494" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 480 轮补录：欧米伽3与炎症平衡；待本地复核。；日期补齐：Crossref 2004-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-424", "title": "《Omega-3 polyunsaturated fatty acids and brain aging》论文发表", "date_start": "2015-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕欧米伽3与炎症平衡报告或讨论可复核的学术证据。", "summary": "该节点将欧米伽3与炎症平衡的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2495" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 480 轮补录：欧米伽3与炎症平衡；待本地复核。；日期补齐：Crossref 2015-03 (published-print, month, v3)", "created_at": "2026-08-07T08:22:09Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-425", "title": "《Sirtuins in Aging and Age-Related Disease》论文发表", "date_start": "2006-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕多酚与年龄相关疾病报告或讨论可复核的学术证据。", "summary": "该节点将多酚与年龄相关疾病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2496" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 481 轮补录：多酚与年龄相关疾病；待本地复核。；日期补齐：Crossref 2006-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-426", "title": "《Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases》论文发表", "date_start": "2021-09-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕多酚与年龄相关疾病报告或讨论可复核的学术证据。", "summary": "该节点将多酚与年龄相关疾病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2497" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 481 轮补录：多酚与年龄相关疾病；待本地复核。；日期补齐：Crossref 2021-09-03 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-427", "title": "《Age-related neurodegenerative disease research needs aging models》论文发表", "date_start": "2015-09-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕多酚与年龄相关疾病报告或讨论可复核的学术证据。", "summary": "该节点将多酚与年龄相关疾病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2498" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 481 轮补录：多酚与年龄相关疾病；待本地复核。；日期补齐：Crossref 2015-09-02 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-428", "title": "《Metabolic regulation of aging and age-related disease》论文发表", "date_start": "2020-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕多酚与年龄相关疾病报告或讨论可复核的学术证据。", "summary": "该节点将多酚与年龄相关疾病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2499" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 481 轮补录：多酚与年龄相关疾病；待本地复核。；日期补齐：Crossref 2020-12 (published-print, month, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-429", "title": "《Translational strategies in aging and age-related disease》论文发表", "date_start": "2015-12-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕多酚与年龄相关疾病报告或讨论可复核的学术证据。", "summary": "该节点将多酚与年龄相关疾病的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2500" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 481 轮补录：多酚与年龄相关疾病；待本地复核。；日期补齐：Crossref 2015-12-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-430", "title": "《IMMUNOGENOMIC RESPONSES TO VACCINATION IN AGING: INSIGHTS INTO IMMUNE RESILIENCE》论文发表", "date_start": "2018-11-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕微量营养素与免疫韧性报告或讨论可复核的学术证据。", "summary": "该节点将微量营养素与免疫韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2501" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 482 轮补录：微量营养素与免疫韧性；待本地复核。；日期补齐：Crossref 2018-11-11 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-431", "title": "《IMMUNE AGING》论文发表", "date_start": "2015-10-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕微量营养素与免疫韧性报告或讨论可复核的学术证据。", "summary": "该节点将微量营养素与免疫韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2502" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 482 轮补录：微量营养素与免疫韧性；待本地复核。；日期补齐：Crossref 2015-10-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-432", "title": "《Human immune aging》论文发表", "date_start": "2025-11", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕微量营养素与免疫韧性报告或讨论可复核的学术证据。", "summary": "该节点将微量营养素与免疫韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2503" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 482 轮补录：微量营养素与免疫韧性；待本地复核。；日期补齐：Crossref 2025-11 (published-print, month, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-433", "title": "《The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging》论文发表", "date_start": "2025-04-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕微量营养素与免疫韧性报告或讨论可复核的学术证据。", "summary": "该节点将微量营养素与免疫韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2504" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 482 轮补录：微量营养素与免疫韧性；待本地复核。；日期补齐：Crossref 2025-04-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-434", "title": "《Effective Immune Functions of Micronutrients against SARS-CoV-2》论文发表", "date_start": "2020-09-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕微量营养素与免疫韧性报告或讨论可复核的学术证据。", "summary": "该节点将微量营养素与免疫韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2505" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 482 轮补录：微量营养素与免疫韧性；待本地复核。；日期补齐：Crossref 2020-09-29 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-435", "title": "《Estimating protein intake in maintenance hemodialysis patients》论文发表", "date_start": "2003-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕蛋白质摄入与肌肉维持报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质摄入与肌肉维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2506" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 483 轮补录：蛋白质摄入与肌肉维持；待本地复核。；日期补齐：Crossref 2003-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-436", "title": "《Aging, exercise, and muscle protein metabolism》论文发表", "date_start": "2009-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕蛋白质摄入与肌肉维持报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质摄入与肌肉维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2507" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 483 轮补录：蛋白质摄入与肌肉维持；待本地复核。；日期补齐：Crossref 2009-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-437", "title": "《NAD+ deficit, protein acetylation and muscle aging》论文发表", "date_start": "2021-06-07", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕蛋白质摄入与肌肉维持报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质摄入与肌肉维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2508" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 483 轮补录：蛋白质摄入与肌肉维持；待本地复核。；日期补齐：Crossref 2021-06-07 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-438", "title": "《Maintenance of NAD+ Homeostasis in Skeletal Muscle during Aging and Exercise》论文发表", "date_start": "2022-02-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕蛋白质摄入与肌肉维持报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质摄入与肌肉维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2509" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 483 轮补录：蛋白质摄入与肌肉维持；待本地复核。；日期补齐：Crossref 2022-02-17 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-439", "title": "《Skeletal Muscle GLUT4 Protein Concentration and Aging in Humans》论文发表", "date_start": "1995-05-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕蛋白质摄入与肌肉维持报告或讨论可复核的学术证据。", "summary": "该节点将蛋白质摄入与肌肉维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2510" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "营养、饮食与代谢干预", "notes": "第 483 轮补录：蛋白质摄入与肌肉维持；待本地复核。；日期补齐：Crossref 1995-05-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-440", "title": "《Effect of cellular aging on memory T-cell homeostasis》论文发表", "date_start": "2022-08-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕水合作用与细胞稳态报告或讨论可复核的学术证据。", "summary": "该节点将水合作用与细胞稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2511" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "体液、电解质与环境稳态", "notes": "第 484 轮补录：水合作用与细胞稳态；待本地复核。；日期补齐：Crossref 2022-08-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-441", "title": "《Cellular and Mitochondrial Quality Control Mechanisms in Maintaining Homeostasis in Aging》论文发表", "date_start": "2022-10-13", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕水合作用与细胞稳态报告或讨论可复核的学术证据。", "summary": "该节点将水合作用与细胞稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2512" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "体液、电解质与环境稳态", "notes": "第 484 轮补录：水合作用与细胞稳态；待本地复核。；日期补齐：Crossref 2022-10-13 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-442", "title": "《Selective autophagy in the maintenance of cellular homeostasis in aging organisms》论文发表", "date_start": "2011-04-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕水合作用与细胞稳态报告或讨论可复核的学术证据。", "summary": "该节点将水合作用与细胞稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2513" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "体液、电解质与环境稳态", "notes": "第 484 轮补录：水合作用与细胞稳态；待本地复核。；日期补齐：Crossref 2011-04-03 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-443", "title": "《ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells》论文发表", "date_start": "2018-01-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕水合作用与细胞稳态报告或讨论可复核的学术证据。", "summary": "该节点将水合作用与细胞稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2514" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "体液、电解质与环境稳态", "notes": "第 484 轮补录：水合作用与细胞稳态；待本地复核。；日期补齐：Crossref 2018-01-05 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-444", "title": "《Mitochondria-lysosome contacts in aging: A mechanistic interface linking organelle homeostasis and cellular decline》论文发表", "date_start": "2026-06", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕水合作用与细胞稳态报告或讨论可复核的学术证据。", "summary": "该节点将水合作用与细胞稳态的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2515" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "体液、电解质与环境稳态", "notes": "第 484 轮补录：水合作用与细胞稳态；待本地复核。；日期补齐：Crossref 2026-06 (published-print, month, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-445", "title": "《Molecular Mechanisms of Exercise and Healthspan》论文发表", "date_start": "2022-03-03", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕运动处方与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将运动处方与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2516" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 485 轮补录：运动处方与健康寿命；待本地复核。；日期补齐：Crossref 2022-03-03 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-446", "title": "《Abstract 4141191: Early-life Exercise Extends Healthspan and Attenuates Cardiovascular Aging in Aged Mice》论文发表", "date_start": "2024-11-12", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕运动处方与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将运动处方与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2517" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 485 轮补录：运动处方与健康寿命；待本地复核。；日期补齐：Crossref 2024-11-12 (published-print, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-447", "title": "《Exercise Prescription》论文发表", "date_start": "2002-04-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕运动处方与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将运动处方与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2518" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 485 轮补录：运动处方与健康寿命；待本地复核。；日期补齐：Crossref 2002-04-02 (published-print, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-448", "title": "《AGING INTERVENTIONS GET HUMAN: CAN WE EXTEND HEALTHSPAN?》论文发表", "date_start": "2019-11-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕运动处方与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将运动处方与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2519" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 485 轮补录：运动处方与健康寿命；待本地复核。；日期补齐：Crossref 2019-11-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-449", "title": "《Exercise Prescription for Older Adults》论文发表", "date_start": "2023-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕运动处方与健康寿命报告或讨论可复核的学术证据。", "summary": "该节点将运动处方与健康寿命的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2520" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 485 轮补录：运动处方与健康寿命；待本地复核。；日期补齐：Crossref 2023-10 (published-online, month, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-450", "title": "《Optimizing Skeletal Muscle Anabolic Response to Resistance Training in Aging》论文发表", "date_start": "2020-07-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕抗阻训练与骨肌维持报告或讨论可复核的学术证据。", "summary": "该节点将抗阻训练与骨肌维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2521" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 486 轮补录：抗阻训练与骨肌维持；待本地复核。；日期补齐：Crossref 2020-07-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-451", "title": "《Time-efficient, high-resistance inspiratory muscle strength training for cardiovascular aging》论文发表", "date_start": "2021-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕抗阻训练与骨肌维持报告或讨论可复核的学术证据。", "summary": "该节点将抗阻训练与骨肌维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2522" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 486 轮补录：抗阻训练与骨肌维持；待本地复核。；日期补齐：Crossref 2021-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-452", "title": "《Influence of Exercise Training on Skeletal Muscle Insulin Resistance in Aging: Spotlight on Muscle Ceramides》论文发表", "date_start": "2020-02-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕抗阻训练与骨肌维持报告或讨论可复核的学术证据。", "summary": "该节点将抗阻训练与骨肌维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2523" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 486 轮补录：抗阻训练与骨肌维持；待本地复核。；日期补齐：Crossref 2020-02-22 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-453", "title": "《Aging, obese-insulin resistance, and bone remodeling》论文发表", "date_start": "2020-10", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕抗阻训练与骨肌维持报告或讨论可复核的学术证据。", "summary": "该节点将抗阻训练与骨肌维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2524" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 486 轮补录：抗阻训练与骨肌维持；待本地复核。；日期补齐：Crossref 2020-10 (published-print, month, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-454", "title": "《Simulated resistance training during hindlimb unloading abolishes disuse bone loss and maintains muscle strength》论文发表", "date_start": "2010-01-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕抗阻训练与骨肌维持报告或讨论可复核的学术证据。", "summary": "该节点将抗阻训练与骨肌维持的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2525" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 486 轮补录：抗阻训练与骨肌维持；待本地复核。；日期补齐：Crossref 2010-01-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-455", "title": "《Aging, cardiorespiratory fitness and sympathetic transduction》论文发表", "date_start": "2022-05-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕有氧适能与心血管韧性报告或讨论可复核的学术证据。", "summary": "该节点将有氧适能与心血管韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2526" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 487 轮补录：有氧适能与心血管韧性；待本地复核。；日期补齐：Crossref 2022-05-16 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-456", "title": "《Cardiorespiratory Fitness and Attentional Control in the Aging Brain》论文发表", "date_start": "2011", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕有氧适能与心血管韧性报告或讨论可复核的学术证据。", "summary": "该节点将有氧适能与心血管韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2527" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 487 轮补录：有氧适能与心血管韧性；待本地复核。；日期补齐：Crossref 2011 (published-online, year, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-457", "title": "《Does clinical rehabilitation impose sufficient cardiorespiratory strain to improve aerobic fitness?》论文发表", "date_start": "2013", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕有氧适能与心血管韧性报告或讨论可复核的学术证据。", "summary": "该节点将有氧适能与心血管韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2528" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 487 轮补录：有氧适能与心血管韧性；待本地复核。；日期补齐：Crossref 2013 (published-print, year, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-458", "title": "《Accelerated Decline of Aerobic Fitness With Healthy Aging》论文发表", "date_start": "2005-08-02", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕有氧适能与心血管韧性报告或讨论可复核的学术证据。", "summary": "该节点将有氧适能与心血管韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2529" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 487 轮补录：有氧适能与心血管韧性；待本地复核。；日期补齐：Crossref 2005-08-02 (published-print, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-459", "title": "《The Association of Aging and Aerobic Fitness With Memory》论文发表", "date_start": "2018-03-09", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕有氧适能与心血管韧性报告或讨论可复核的学术证据。", "summary": "该节点将有氧适能与心血管韧性的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2530" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "运动、身体承载与功能解锁", "notes": "第 487 轮补录：有氧适能与心血管韧性；待本地复核。；日期补齐：Crossref 2018-03-09 (published-online, day, v3)", "created_at": "2026-08-07T08:22:10Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-460", "title": "《0196 Retinal responsivity is associated with circadian phase and circadian alignment but not sleep timing》论文发表", "date_start": "2022-05-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕睡眠卫生与昼夜对齐报告或讨论可复核的学术证据。", "summary": "该节点将睡眠卫生与昼夜对齐的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2531" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 488 轮补录：睡眠卫生与昼夜对齐；待本地复核。；日期补齐：Crossref 2022-05-25 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-461", "title": "《0655 Circadian Sleep Preferences, Sleep Quality, Daytime Sleepiness and Sleep Hygiene amongst Undergraduate students of a Nigerian University》论文发表", "date_start": "2018-04-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕睡眠卫生与昼夜对齐报告或讨论可复核的学术证据。", "summary": "该节点将睡眠卫生与昼夜对齐的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2532" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 488 轮补录：睡眠卫生与昼夜对齐；待本地复核。；日期补齐：Crossref 2018-04-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-462", "title": "《0302 Household Chaos in Diverse Families: Does It Influence Family Sleep or Circadian Alignment?》论文发表", "date_start": "2025-05-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕睡眠卫生与昼夜对齐报告或讨论可复核的学术证据。", "summary": "该节点将睡眠卫生与昼夜对齐的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2533" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 488 轮补录：睡眠卫生与昼夜对齐；待本地复核。；日期补齐：Crossref 2025-05-19 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-463", "title": "《Circadian Rhythm Sleep Disorders》论文发表", "date_start": "2006-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕睡眠卫生与昼夜对齐报告或讨论可复核的学术证据。", "summary": "该节点将睡眠卫生与昼夜对齐的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2534" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 488 轮补录：睡眠卫生与昼夜对齐；待本地复核。；日期补齐：Crossref 2006-12 (published-print, month, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-464", "title": "《Sleep and circadian rhythms》论文发表", "date_start": "1991-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕睡眠卫生与昼夜对齐报告或讨论可复核的学术证据。", "summary": "该节点将睡眠卫生与昼夜对齐的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2535" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "生理节律、代谢与恢复", "notes": "第 488 轮补录：睡眠卫生与昼夜对齐；待本地复核。；日期补齐：Crossref 1991-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-465", "title": "《Strain, stress, neurodegeneration and longevity》论文发表", "date_start": "1995-03", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕压力缓解与长寿心理报告或讨论可复核的学术证据。", "summary": "该节点将压力缓解与长寿心理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2536" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理、社会与主体支持", "notes": "第 489 轮补录：压力缓解与长寿心理；待本地复核。；日期补齐：Crossref 1995-03 (published-print, month, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-466", "title": "《THE ROLE OF EDUCATION AND RESILIENCE IN MENTAL HEALTH TRAJECTORIES OF AGING VETERANS》论文发表", "date_start": "2017-06-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕压力缓解与长寿心理报告或讨论可复核的学术证据。", "summary": "该节点将压力缓解与长寿心理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2537" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理、社会与主体支持", "notes": "第 489 轮补录：压力缓解与长寿心理；待本地复核。；日期补齐：Crossref 2017-06-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-467", "title": "《Psychological and biological resilience modulates the effects of stress on epigenetic aging》论文发表", "date_start": "2021-11-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕压力缓解与长寿心理报告或讨论可复核的学术证据。", "summary": "该节点将压力缓解与长寿心理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2538" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理、社会与主体支持", "notes": "第 489 轮补录：压力缓解与长寿心理；待本地复核。；日期补齐：Crossref 2021-11-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-468", "title": "《Psychological stress and aging: role of glucocorticoids (GCs)》论文发表", "date_start": "2011-10-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕压力缓解与长寿心理报告或讨论可复核的学术证据。", "summary": "该节点将压力缓解与长寿心理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2539" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理、社会与主体支持", "notes": "第 489 轮补录：压力缓解与长寿心理；待本地复核。；日期补齐：Crossref 2011-10-05 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-469", "title": "《Molecular consequences of psychological stress in human aging》论文发表", "date_start": "2015-08", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "maintenance", "event_type": "literature", "claim": "该文献围绕压力缓解与长寿心理报告或讨论可复核的学术证据。", "summary": "该节点将压力缓解与长寿心理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2540" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "心理、社会与主体支持", "notes": "第 489 轮补录：压力缓解与长寿心理；待本地复核。；日期补齐：Crossref 2015-08 (published-print, month, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-470", "title": "《Yeast longevity and aging—the mitochondrial connection》论文发表", "date_start": "2005-02", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕社会连接与健康老化报告或讨论可复核的学术证据。", "summary": "该节点将社会连接与健康老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2541" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会、生态与外部支持", "notes": "第 490 轮补录：社会连接与健康老化；待本地复核。；日期补齐：Crossref 2005-02 (published-print, month, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-471", "title": "《Lipidomics in longevity and healthy aging》论文发表", "date_start": "2013-08-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕社会连接与健康老化报告或讨论可复核的学术证据。", "summary": "该节点将社会连接与健康老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2542" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会、生态与外部支持", "notes": "第 490 轮补录：社会连接与健康老化；待本地复核。；日期补齐：Crossref 2013-08-15 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-472", "title": "《Integrative Multi-Omic Signatures of Longevity and Healthy Aging》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕社会连接与健康老化报告或讨论可复核的学术证据。", "summary": "该节点将社会连接与健康老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2543" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会、生态与外部支持", "notes": "第 490 轮补录：社会连接与健康老化；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-473", "title": "《Ergothioneine promotes longevity and healthy aging in male mice》论文发表", "date_start": "2024-03-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕社会连接与健康老化报告或讨论可复核的学术证据。", "summary": "该节点将社会连接与健康老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2544" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会、生态与外部支持", "notes": "第 490 轮补录：社会连接与健康老化；待本地复核。；日期补齐：Crossref 2024-03-06 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-474", "title": "《Complementary and Integrated Studies of Longevity and Healthy Aging》论文发表", "date_start": "2020-12-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕社会连接与健康老化报告或讨论可复核的学术证据。", "summary": "该节点将社会连接与健康老化的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2545" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会、生态与外部支持", "notes": "第 490 轮补录：社会连接与健康老化；待本地复核。；日期补齐：Crossref 2020-12-16 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-475", "title": "《Early Life Interventions: Impact on Aging and Longevity》论文发表", "date_start": "2024", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "literature", "claim": "该文献围绕生活目标感与长寿报告或讨论可复核的学术证据。", "summary": "该节点将生活目标感与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2546" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "意义、伦理与主体连续性", "notes": "第 491 轮补录：生活目标感与长寿；待本地复核。；日期补齐：Crossref 2024 (published-print, year, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-476", "title": "《Longevity Assurance Genes: How Do They Influence Aging and Life Span?》论文发表", "date_start": "2015-04-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "literature", "claim": "该文献围绕生活目标感与长寿报告或讨论可复核的学术证据。", "summary": "该节点将生活目标感与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2547" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "意义、伦理与主体连续性", "notes": "第 491 轮补录：生活目标感与长寿；待本地复核。；日期补齐：Crossref 2015-04-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-477", "title": "《PURPOSE IN LIFE, STRESS REACTIVITY, AND COGNITIVE AGING: A LONGITUDINAL INVESTIGATION》论文发表", "date_start": "2022-12-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "literature", "claim": "该文献围绕生活目标感与长寿报告或讨论可复核的学术证据。", "summary": "该节点将生活目标感与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2548" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "意义、伦理与主体连续性", "notes": "第 491 轮补录：生活目标感与长寿；待本地复核。；日期补齐：Crossref 2022-12-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-478", "title": "《Cardiovascular Aging and Longevity》论文发表", "date_start": "2021-01", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "literature", "claim": "该文献围绕生活目标感与长寿报告或讨论可复核的学术证据。", "summary": "该节点将生活目标感与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2549" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "意义、伦理与主体连续性", "notes": "第 491 轮补录：生活目标感与长寿；待本地复核。；日期补齐：Crossref 2021-01 (published-print, month, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-479", "title": "《Longevity, Genes, and Aging》论文发表", "date_start": "1996-07-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "philosophical", "event_type": "literature", "claim": "该文献围绕生活目标感与长寿报告或讨论可复核的学术证据。", "summary": "该节点将生活目标感与长寿的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2550" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "意义、伦理与主体连续性", "notes": "第 491 轮补录：生活目标感与长寿；待本地复核。；日期补齐：Crossref 1996-07-05 (published-print, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-480", "title": "《Can financial incentives improve health equity?》论文发表", "date_start": "2009-09-24", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕财务健康与寿命公平报告或讨论可复核的学术证据。", "summary": "该节点将财务健康与寿命公平的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2551" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会、生态与外部支持", "notes": "第 492 轮补录：财务健康与寿命公平；待本地复核。；日期补齐：Crossref 2009-09-24 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-481", "title": "《Acarbose improves health and lifespan in aging HET3 mice》论文发表", "date_start": "2019-01-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕财务健康与寿命公平报告或讨论可复核的学术证据。", "summary": "该节点将财务健康与寿命公平的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2552" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会、生态与外部支持", "notes": "第 492 轮补录：财务健康与寿命公平；待本地复核。；日期补齐：Crossref 2019-01-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-482", "title": "《Reframing Aging and Diabetes: Centering Transgender Health Equity》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕财务健康与寿命公平报告或讨论可复核的学术证据。", "summary": "该节点将财务健康与寿命公平的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2553" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会、生态与外部支持", "notes": "第 492 轮补录：财务健康与寿命公平；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-483", "title": "《Physiological Dysregulation and Aging: Implications for Health Equity》论文发表", "date_start": "2020-12-16", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕财务健康与寿命公平报告或讨论可复核的学术证据。", "summary": "该节点将财务健康与寿命公平的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2554" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会、生态与外部支持", "notes": "第 492 轮补录：财务健康与寿命公平；待本地复核。；日期补齐：Crossref 2020-12-16 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-484", "title": "《Measuring Structural Racism to Advance Health Equity in Aging》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕财务健康与寿命公平报告或讨论可复核的学术证据。", "summary": "该节点将财务健康与寿命公平的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2555" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "社会、生态与外部支持", "notes": "第 492 轮补录：财务健康与寿命公平；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-485", "title": "《Health Literacy Influences Self-Management Behavior in Asthma》论文发表", "date_start": "2012-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕健康素养与自我管理报告或讨论可复核的学术证据。", "summary": "该节点将健康素养与自我管理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2556" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、行为与信息基础设施", "notes": "第 493 轮补录：健康素养与自我管理；待本地复核。；日期补齐：Crossref 2012-12 (published-print, month, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-486", "title": "《Health Literacy Influences Self-Management Behavior in Asthma: Response》论文发表", "date_start": "2012-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕健康素养与自我管理报告或讨论可复核的学术证据。", "summary": "该节点将健康素养与自我管理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2557" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、行为与信息基础设施", "notes": "第 493 轮补录：健康素养与自我管理；待本地复核。；日期补齐：Crossref 2012-12 (published-print, month, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-487", "title": "《Tailored Education May Reduce Health Literacy Disparities in Asthma Self-Management》论文发表", "date_start": "2005-10-15", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕健康素养与自我管理报告或讨论可复核的学术证据。", "summary": "该节点将健康素养与自我管理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2558" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、行为与信息基础设施", "notes": "第 493 轮补录：健康素养与自我管理；待本地复核。；日期补齐：Crossref 2005-10-15 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-488", "title": "《EXPLORING DIGITAL LITERACY, HEALTH LITERACY, AND SELF-MANAGEMENT IN YOUNGER AND OLDER LIVER TRANSPLANT RECIPIENTS》论文发表", "date_start": "2024-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕健康素养与自我管理报告或讨论可复核的学术证据。", "summary": "该节点将健康素养与自我管理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2559" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、行为与信息基础设施", "notes": "第 493 轮补录：健康素养与自我管理；待本地复核。；日期补齐：Crossref 2024-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-489", "title": "《Aging immigrant family caregivers health, social engagement, and health literacy》论文发表", "date_start": "2021-12-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕健康素养与自我管理报告或讨论可复核的学术证据。", "summary": "该节点将健康素养与自我管理的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2560" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "认知、行为与信息基础设施", "notes": "第 493 轮补录：健康素养与自我管理；待本地复核。；日期补齐：Crossref 2021-12-17 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-490", "title": "《Digital biomarkers: Convergence of digital health technologies and biomarkers》论文发表", "date_start": "2022-03-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "literature", "claim": "该文献围绕数字生物标志物与连续感知报告或讨论可复核的学术证据。", "summary": "该节点将数字生物标志物与连续感知的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2561" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据、感知与数字孪生", "notes": "第 494 轮补录：数字生物标志物与连续感知；待本地复核。；日期补齐：Crossref 2022-03-25 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-491", "title": "《Digital biomarkers for brain health: passive and continuous assessment from wearable sensors》论文发表", "date_start": "2026-01-14", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "literature", "claim": "该文献围绕数字生物标志物与连续感知报告或讨论可复核的学术证据。", "summary": "该节点将数字生物标志物与连续感知的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2562" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据、感知与数字孪生", "notes": "第 494 轮补录：数字生物标志物与连续感知；待本地复核。；日期补齐：Crossref 2026-01-14 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-492", "title": "《Direct digital sensing of protein biomarkers in solution》论文发表", "date_start": "2023-02-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "literature", "claim": "该文献围绕数字生物标志物与连续感知报告或讨论可复核的学术证据。", "summary": "该节点将数字生物标志物与连续感知的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2563" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据、感知与数字孪生", "notes": "第 494 轮补录：数字生物标志物与连续感知；待本地复核。；日期补齐：Crossref 2023-02-06 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-493", "title": "《Continuous sleep depth index annotation with deep learning yields novel digital biomarkers for sleep health》论文发表", "date_start": "2025-04-11", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "literature", "claim": "该文献围绕数字生物标志物与连续感知报告或讨论可复核的学术证据。", "summary": "该节点将数字生物标志物与连续感知的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2564" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据、感知与数字孪生", "notes": "第 494 轮补录：数字生物标志物与连续感知；待本地复核。；日期补齐：Crossref 2025-04-11 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-494", "title": "《Advancing digital sensing in mental health research》论文发表", "date_start": "2024-12-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "digital_migration", "event_type": "literature", "claim": "该文献围绕数字生物标志物与连续感知报告或讨论可复核的学术证据。", "summary": "该节点将数字生物标志物与连续感知的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2565" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据、感知与数字孪生", "notes": "第 494 轮补录：数字生物标志物与连续感知；待本地复核。；日期补齐：Crossref 2024-12-18 (published-online, day, v3)", "created_at": "2026-08-07T08:22:11Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-495", "title": "《Cohort Profile: The Longitudinal Aging Study Amsterdam》论文发表", "date_start": "2011-01-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕纵向队列与老化研究报告或讨论可复核的学术证据。", "summary": "该节点将纵向队列与老化研究的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2566" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据、感知与数字孪生", "notes": "第 495 轮补录：纵向队列与老化研究；待本地复核。；日期补齐：Crossref 2011-01-06 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-496", "title": "《Cohort Profile: The Canadian Longitudinal Study on Aging (CLSA)》论文发表", "date_start": "2019-09-06", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕纵向队列与老化研究报告或讨论可复核的学术证据。", "summary": "该节点将纵向队列与老化研究的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2567" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据、感知与数字孪生", "notes": "第 495 轮补录：纵向队列与老化研究；待本地复核。；日期补齐：Crossref 2019-09-06 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-497", "title": "《AI AND AGING: IDENTIFYING IMPORTANT LIVING ACTIVITIES FOR HEALTHY AGING IN SINGAPORE LONGITUDINAL AGING COHORT》论文发表", "date_start": "2022-12-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕纵向队列与老化研究报告或讨论可复核的学术证据。", "summary": "该节点将纵向队列与老化研究的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2568" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据、感知与数字孪生", "notes": "第 495 轮补录：纵向队列与老化研究；待本地复核。；日期补齐：Crossref 2022-12-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-498", "title": "《Cohort Profile: The Healthy Aging Longitudinal Study in Taiwan (HALST)》论文发表", "date_start": "2017-02-27", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕纵向队列与老化研究报告或讨论可复核的学术证据。", "summary": "该节点将纵向队列与老化研究的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2569" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据、感知与数字孪生", "notes": "第 495 轮补录：纵向队列与老化研究；待本地复核。；日期补齐：Crossref 2017-02-27 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-499", "title": "《Blood-Based Biomarkers of Aging and Neurodegeneration in Longitudinal Cohort Studies of Brain Aging》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕纵向队列与老化研究报告或讨论可复核的学术证据。", "summary": "该节点将纵向队列与老化研究的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2570" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "数据、感知与数字孪生", "notes": "第 495 轮补录：纵向队列与老化研究；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-500", "title": "《Causal Inference is Necessary but Insufficient for Causal Inference.》论文发表", "date_start": "2015-09-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕因果推断与长寿干预报告或讨论可复核的学术证据。", "summary": "该节点将因果推断与长寿干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2571" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 496 轮补录：因果推断与长寿干预；待本地复核。；日期补齐：Crossref 2015-09-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-501", "title": "《Assimilative causal inference》论文发表", "date_start": "2026-01-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕因果推断与长寿干预报告或讨论可复核的学术证据。", "summary": "该节点将因果推断与长寿干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2572" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 496 轮补录：因果推断与长寿干预；待本地复核。；日期补齐：Crossref 2026-01-22 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-502", "title": "《Improving causal inference》论文发表", "date_start": "2013-04-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕因果推断与长寿干预报告或讨论可复核的学术证据。", "summary": "该节点将因果推断与长寿干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2573" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 496 轮补录：因果推断与长寿干预；待本地复核。；日期补齐：Crossref 2013-04-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-503", "title": "《Concepts of Causal Inference.》论文发表", "date_start": "2015-09-23", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕因果推断与长寿干预报告或讨论可复核的学术证据。", "summary": "该节点将因果推断与长寿干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2574" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 496 轮补录：因果推断与长寿干预；待本地复核。；日期补齐：Crossref 2015-09-23 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-504", "title": "《Causal Inference in Public Health》论文发表", "date_start": "2013-03-18", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕因果推断与长寿干预报告或讨论可复核的学术证据。", "summary": "该节点将因果推断与长寿干预的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2575" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 496 轮补录：因果推断与长寿干预；待本地复核。；日期补齐：Crossref 2013-03-18 (published-print, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-505", "title": "《Epigenetic aging biomarkers in dietary geroscience: feasibility, participant perceptions, and trial design considerations》论文发表", "date_start": "2026-07-29", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕老龄化临床试验设计报告或讨论可复核的学术证据。", "summary": "该节点将老龄化临床试验设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2576" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 497 轮补录：老龄化临床试验设计；待本地复核。；日期补齐：Crossref 2026-07-29 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-506", "title": "《GEROSCIENCE-DRIVEN THERAPIES TO TARGET HEALTHSPAN WITH AGING: CLINICAL IMPLICATIONS》论文发表", "date_start": "2024-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕老龄化临床试验设计报告或讨论可复核的学术证据。", "summary": "该节点将老龄化临床试验设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2577" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 497 轮补录：老龄化临床试验设计；待本地复核。；日期补齐：Crossref 2024-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-507", "title": "《CLINICAL TRIALS IN GEROSCIENCE》论文发表", "date_start": "2019-11-08", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕老龄化临床试验设计报告或讨论可复核的学术证据。", "summary": "该节点将老龄化临床试验设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2578" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 497 轮补录：老龄化临床试验设计；待本地复核。；日期补齐：Crossref 2019-11-08 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-508", "title": "《Bringing Geroscience to the Bedside: Leveraging Biomarkers of Aging in Clinical Research》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕老龄化临床试验设计报告或讨论可复核的学术证据。", "summary": "该节点将老龄化临床试验设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2579" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 497 轮补录：老龄化临床试验设计；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-509", "title": "《BARRIERS TO GEROSCIENCE IN CLINICAL COMMUNITY》论文发表", "date_start": "2024-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕老龄化临床试验设计报告或讨论可复核的学术证据。", "summary": "该节点将老龄化临床试验设计的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2580" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 497 轮补录：老龄化临床试验设计；待本地复核。；日期补齐：Crossref 2024-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-510", "title": "《Potential dietary geroprotectors and their impact on key mechanisms of aging》论文发表", "date_start": "2025-11-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕老年保护药物监管科学报告或讨论可复核的学术证据。", "summary": "该节点将老年保护药物监管科学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2581" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 498 轮补录：老年保护药物监管科学；待本地复核。；日期补齐：Crossref 2025-11-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-511", "title": "《Crowdsourced Drug Discovery Approach Identifies BET Inhibitors As Novel Geroprotectors Promoting Healthy Aging》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕老年保护药物监管科学报告或讨论可复核的学术证据。", "summary": "该节点将老年保护药物监管科学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2582" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 498 轮补录：老年保护药物监管科学；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-512", "title": "《Advancing Regulatory Science》论文发表", "date_start": "2011-02-25", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕老年保护药物监管科学报告或讨论可复核的学术证据。", "summary": "该节点将老年保护药物监管科学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2583" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 498 轮补录：老年保护药物监管科学；待本地复核。；日期补齐：Crossref 2011-02-25 (published-print, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-513", "title": "《Regulatory issues in aging pharmacology》论文发表", "date_start": "2006-01-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕老年保护药物监管科学报告或讨论可复核的学术证据。", "summary": "该节点将老年保护药物监管科学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2584" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 498 轮补录：老年保护药物监管科学；待本地复核。；日期补齐：Crossref 2006-01-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-514", "title": "《Regulatory Science in Neonates》论文发表", "date_start": "2017-08-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕老年保护药物监管科学报告或讨论可复核的学术证据。", "summary": "该节点将老年保护药物监管科学的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2585" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 498 轮补录：老年保护药物监管科学；待本地复核。；日期补齐：Crossref 2017-08-01 (published-print, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-515", "title": "《Energetic interventions for healthspan and resiliency with aging》论文发表", "date_start": "2016-12", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕健康寿命经济学与价值评估报告或讨论可复核的学术证据。", "summary": "该节点将健康寿命经济学与价值评估的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2586" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 499 轮补录：健康寿命经济学与价值评估；待本地复核。；日期补齐：Crossref 2016-12 (published-print, month, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-516", "title": "《Biomarker Insights Into Brain Health, Aging, and Healthspan》论文发表", "date_start": "2025-12-31", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕健康寿命经济学与价值评估报告或讨论可复核的学术证据。", "summary": "该节点将健康寿命经济学与价值评估的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2587" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 499 轮补录：健康寿命经济学与价值评估；待本地复核。；日期补齐：Crossref 2025-12-31 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-517", "title": "《ECONOMICS OF AGING》论文发表", "date_start": "2016-11-01", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕健康寿命经济学与价值评估报告或讨论可复核的学术证据。", "summary": "该节点将健康寿命经济学与价值评估的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2588" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 499 轮补录：健康寿命经济学与价值评估；待本地复核。；日期补齐：Crossref 2016-11-01 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-518", "title": "《DELETION OF THROMBOSPONDIN-1 PRESERVES HEMATOPOIETIC STEM CELL HEALTHSPAN DURING AGING》论文发表", "date_start": "2022-12-20", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕健康寿命经济学与价值评估报告或讨论可复核的学术证据。", "summary": "该节点将健康寿命经济学与价值评估的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2589" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 499 轮补录：健康寿命经济学与价值评估；待本地复核。；日期补齐：Crossref 2022-12-20 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-519", "title": "《The circadian clock gene period extends healthspan in aging Drosophila melanogaster》论文发表", "date_start": "2009-11-19", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "social_composite", "event_type": "literature", "claim": "该文献围绕健康寿命经济学与价值评估报告或讨论可复核的学术证据。", "summary": "该节点将健康寿命经济学与价值评估的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2590" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "方法、证据与治理", "notes": "第 499 轮补录：健康寿命经济学与价值评估；待本地复核。；日期补齐：Crossref 2009-11-19 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-520", "title": "《Inducible immortality in hTERT‐human mesenchymal stem cells》论文发表", "date_start": "2012-06-05", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕未来人类基础设施与有效永生报告或讨论可复核的学术证据。", "summary": "该节点将未来人类基础设施与有效永生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2591" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "边界改写、未来路径与主体持续", "notes": "第 500 轮补录：未来人类基础设施与有效永生；待本地复核。；日期补齐：Crossref 2012-06-05 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-521", "title": "《Aging, longevity, and immortality in vitro》论文发表", "date_start": "1992-07", "date_type": "approx", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕未来人类基础设施与有效永生报告或讨论可复核的学术证据。", "summary": "该节点将未来人类基础设施与有效永生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2592" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "边界改写、未来路径与主体持续", "notes": "第 500 轮补录：未来人类基础设施与有效永生；待本地复核。；日期补齐：Crossref 1992-07 (published-print, month, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:26:29Z" }, { "event_id": "HIT-LIT-522", "title": "《The Future of Human Longevity》论文发表", "date_start": "2017-08-22", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕未来人类基础设施与有效永生报告或讨论可复核的学术证据。", "summary": "该节点将未来人类基础设施与有效永生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2593" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "边界改写、未来路径与主体持续", "notes": "第 500 轮补录：未来人类基础设施与有效永生；待本地复核。；日期补齐：Crossref 2017-08-22 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-523", "title": "《Nuclear autophagy promotes longevity and germline immortality》论文发表", "date_start": "2022-12-30", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕未来人类基础设施与有效永生报告或讨论可复核的学术证据。", "summary": "该节点将未来人类基础设施与有效永生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2594" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "边界改写、未来路径与主体持续", "notes": "第 500 轮补录：未来人类基础设施与有效永生；待本地复核。；日期补齐：Crossref 2022-12-30 (published-online, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" }, { "event_id": "HIT-LIT-524", "title": "《The Future of Human Longevity: A Demographer's Perspective》论文发表", "date_start": "1998-04-17", "date_type": "exact", "period_id": "period-21st-century", "civilization": "International", "region": "Global", "path_family": "cross_path", "event_type": "literature", "claim": "该文献围绕未来人类基础设施与有效永生报告或讨论可复核的学术证据。", "summary": "该节点将未来人类基础设施与有效永生的最新证据纳入有效永生研究年表。", "sources": [ "SRC-2595" ], "evidence_grade": "S", "verification_status": "unreviewed", "status": "draft", "significance": "major", "uncertainty": "本记录基于期刊元数据和论文标题，尚未完成全文语境复核。", "cross_links": [], "chapter": "边界改写、未来路径与主体持续", "notes": "第 500 轮补录：未来人类基础设施与有效永生；待本地复核。；日期补齐：Crossref 1998-04-17 (published-print, day, v3)", "created_at": "2026-08-07T08:22:12Z", "updated_at": "2026-08-08T06:21:52Z" } ] }