{"schema_version":"1.0.0","generated_at":"2026-08-07T13:00:00Z","event_count":31,"events":[{"event_id":"HIT-SCI-001","date":{"year":1935},"period":"20 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"麦凯报告限制热量摄入延长大鼠寿命","sources":["SRC-2596"]},{"event_id":"HIT-TEC-002","date":{"year":1951},"period":"20 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"HeLa 细胞系建立","sources":["SRC-2602"]},{"event_id":"HIT-SCI-003","date":{"year":1961},"period":"20 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"Hayflick 极限发表","sources":["SRC-2598"]},{"event_id":"HIT-SCI-004","date":{"year":1983},"period":"20 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"秀丽隐杆线虫长寿突变株被发现","sources":["SRC-2597"]},{"event_id":"HIT-SCI-027","date":{"year":1996,"month":7,"day":5},"period":"20 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"S","verification_status":"locally_reviewed","publication_status":"selected","title":"克隆羊多莉出生，证明体细胞可重编程为新个体","sources":["SRC-2599","SRC-2600"]},{"event_id":"HIT-SCI-007","date":{"year":2006},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"山中伸弥团队建立诱导多能干细胞","sources":["SRC-043"]},{"event_id":"HIT-SCI-033","date":{"year":2012,"month":6,"day":28},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"CRISPR-Cas9 可编程基因编辑论文发表","sources":["SRC-180"]},{"event_id":"HIT-INS-045","date":{"year":2012,"month":10,"day":8},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"institution","event_type_label":"制度与机构","evidence_grade":"S","verification_status":"locally_reviewed","publication_status":"selected","title":"山中伸弥与格登获诺贝尔生理学或医学奖","sources":["SRC-346"]},{"event_id":"HIT-THT-015","date":{"year":2013},"period":"21 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"thought","event_type_label":"思想与概念","evidence_grade":"I","verification_status":"locally_reviewed","publication_status":"selected","title":"《衰老的标志》提出九项统一框架","sources":["SRC-038"]},{"event_id":"HIT-SCI-069","date":{"year":2014,"month":9,"day":12},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"日本实施首例 iPS 细胞来源视网膜色素上皮移植","sources":["SRC-347"]},{"event_id":"HIT-SCI-071","date":{"year":2015},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"S","verification_status":"locally_reviewed","publication_status":"selected","title":"CiRA 开始分发临床级 iPS 细胞储备","sources":["SRC-351"]},{"event_id":"HIT-TEC-005","date":{"year":2016,"month":7,"day":21},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"CRISPR 基因编辑进入人体临床试验探索","sources":["SRC-2601"]},{"event_id":"HIT-FAI-011","date":{"year":2018,"month":11,"day":26},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"failure","event_type_label":"失败与教训","evidence_grade":"S","verification_status":"locally_reviewed","publication_status":"selected","title":"贺建奎 CRISPR 婴儿事件引发全球伦理争议","sources":["SRC-191"]},{"event_id":"HIT-SCI-035","date":{"year":2018,"month":4,"day":18},"period":"21 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"PhenoAge 表观遗传年龄标志物发表","sources":["SRC-207"]},{"event_id":"HIT-SCI-031","date":{"year":2019,"month":9,"day":18},"period":"21 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"首个人体 senolytics 临床报告发表","sources":["SRC-174"]},{"event_id":"HIT-SCI-036","date":{"year":2019,"month":1,"day":21},"period":"21 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"GrimAge 寿命与健康寿命预测标志物发表","sources":["SRC-208"]},{"event_id":"HIT-FAI-009","date":{"year":2020,"month":8,"day":17},"period":"21 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"failure","event_type_label":"失败与教训","evidence_grade":"L","verification_status":"locally_reviewed","publication_status":"selected","title":"UBX0101 senolytics II 期试验失败","sources":["SRC-178"]},{"event_id":"HIT-SCI-072","date":{"year":2020,"month":1,"day":30},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"首例 iPS 细胞来源心肌细胞片移植进入人体","sources":["SRC-352"]},{"event_id":"HIT-TEC-025","date":{"year":2021,"month":7,"day":15},"period":"21 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"AlphaFold 2 实现高精度蛋白质结构预测","sources":["SRC-146"]},{"event_id":"HIT-TEC-026","date":{"year":2021,"month":6,"day":26},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"首个体内 CRISPR 基因编辑临床数据发表","sources":["SRC-155"]},{"event_id":"HIT-SCI-019","date":{"year":2022,"month":1,"day":14},"period":"21 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"DunedinPACE 衰老速度表观遗传标志物发表","sources":["SRC-095"]},{"event_id":"HIT-INS-008","date":{"year":2023},"period":"21 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"institution","event_type_label":"制度与机构","evidence_grade":"S","verification_status":"locally_reviewed","publication_status":"selected","title":"XPRIZE Healthspan 全球竞赛启动","sources":["SRC-089","SRC-090"]},{"event_id":"HIT-INS-016","date":{"year":2023,"month":12,"day":8},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"institution","event_type_label":"制度与机构","evidence_grade":"S","verification_status":"locally_reviewed","publication_status":"selected","title":"FDA 批准首个 CRISPR 基因疗法 Casgevy","sources":["SRC-154"]},{"event_id":"HIT-TEC-027","date":{"year":2024,"month":1,"day":1},"period":"21 世纪","path_family":"maintenance","path_family_label":"生物维护","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"AlphaFold 蛋白质结构数据库覆盖 2.14 亿序列","sources":["SRC-175"]},{"event_id":"HIT-TEC-055","date":{"year":2024,"month":5,"day":8},"period":"21 世纪","path_family":"cognitive_extension","path_family_label":"认知外延","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"S","verification_status":"locally_reviewed","publication_status":"selected","title":"AlphaFold 3 实现生物分子复合物统一结构预测","sources":["SRC-379"]},{"event_id":"HIT-SCI-017","date":{"year":2025,"month":5,"day":31},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"practice","event_type_label":"实践与方法","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"LEV 基金会 Robust Mouse Rejuvenation 首轮研究公布最终结果","sources":["SRC-091","SRC-092"]},{"event_id":"HIT-TEC-013","date":{"year":2025,"month":8,"day":22},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"OpenAI 与 Retro Biosciences 公布 AI 设计增强版山中因子","sources":["SRC-096"]},{"event_id":"HIT-SCI-073","date":{"year":2025,"month":4,"day":16},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"S","verification_status":"locally_reviewed","publication_status":"selected","title":"iPS 细胞来源多巴胺能细胞治疗帕金森病 I/II 期结果发表","sources":["SRC-353"]},{"event_id":"HIT-TEC-014","date":{"year":2026,"month":1,"day":28},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"technology","event_type_label":"技术与工程","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"Life Biosciences ER-100 获 FDA IND 批准","sources":["SRC-100","SRC-101"]},{"event_id":"HIT-PRA-009","date":{"year":2026,"month":6,"day":9},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"practice","event_type_label":"实践与方法","evidence_grade":"T","verification_status":"locally_reviewed","publication_status":"selected","title":"ER-100 完成首例受试者给药","sources":["SRC-102","SRC-101"]},{"event_id":"HIT-INS-048","date":{"year":2026,"month":2,"day":24},"period":"21 世纪","path_family":"reconstruction","path_family_label":"生物重建","event_type":"institution","event_type_label":"制度与机构","evidence_grade":"S","verification_status":"locally_reviewed","publication_status":"selected","title":"日本药事委员会建议推进首个异体 iPS 细胞产品审批","sources":["SRC-354"]}]}